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Aliases for MMS22L Gene

Aliases for MMS22L Gene

  • MMS22-Like, DNA Repair Protein 2 3
  • C6orf167 3 4 6
  • Methyl Methanesulfonate-Sensitivity Protein 22-Like 4
  • Chromosome 6 Open Reading Frame 167 2
  • Protein MMS22-Like 3
  • DJ39B17.2 3

External Ids for MMS22L Gene

Previous HGNC Symbols for MMS22L Gene

  • C6orf167

Previous GeneCards Identifiers for MMS22L Gene

  • GC06M097590

Summaries for MMS22L Gene

GeneCards Summary for MMS22L Gene

MMS22L (MMS22-Like, DNA Repair Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MMS22L Gene

  • Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.

Gene Wiki entry for MMS22L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMS22L Gene

Genomics for MMS22L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMS22L Gene

Start:
97,142,161 bp from pter
End:
97,283,248 bp from pter
Size:
141,088 bases
Orientation:
Minus strand

Genomic View for MMS22L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMS22L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMS22L Gene

No data available for Regulatory Elements for MMS22L Gene

Proteins for MMS22L Gene

  • Protein details for MMS22L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRQ5-MMS22_HUMAN
    Recommended name:
    Protein MMS22-like
    Protein Accession:
    Q6ZRQ5
    Secondary Accessions:
    • D6R9Y8
    • D6RBQ4
    • E1P529
    • Q5THT2
    • Q68CQ6
    • Q68D32

    Protein attributes for MMS22L Gene

    Size:
    1243 amino acids
    Molecular mass:
    142321 Da
    Quaternary structure:
    • Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.
    SequenceCaution:
    • Sequence=CAI16668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20426.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MMS22L Gene

Proteomics data for MMS22L Gene at MOPED

Post-translational modifications for MMS22L Gene

  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for MMS22L Gene

No data available for DME Specific Peptides for MMS22L Gene

Domains for MMS22L Gene

Protein Domains for MMS22L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MMS22L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZRQ5

UniProtKB/Swiss-Prot:

MMS22_HUMAN :
  • Q6ZRQ5
Family:
  • Belongs to the MMS22 family. MMS22L subfamily.
genes like me logo Genes that share domains with MMS22L: view

No data available for Gene Families for MMS22L Gene

Function for MMS22L Gene

Molecular function for MMS22L Gene

UniProtKB/Swiss-Prot Function: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.

Gene Ontology (GO) - Molecular Function for MMS22L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 21055983
genes like me logo Genes that share ontologies with MMS22L: view

Phenotypes for MMS22L Gene

GenomeRNAi human phenotypes for MMS22L:
genes like me logo Genes that share phenotypes with MMS22L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMS22L Gene

Localization for MMS22L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMS22L Gene

Nucleus. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.

Gene Ontology (GO) - Cellular Components for MMS22L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0035101 colocalizes_with FACT complex IDA 21055985
GO:0042555 colocalizes_with MCM complex IDA 21055985
GO:0043596 nuclear replication fork IDA 21055983
genes like me logo Genes that share ontologies with MMS22L: view

No data available for Subcellular locations from COMPARTMENTS for MMS22L Gene

Pathways for MMS22L Gene

SuperPathways for MMS22L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MMS22L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21055983
GO:0031297 replication fork processing IMP 21055983
genes like me logo Genes that share ontologies with MMS22L: view

No data available for Pathways by source for MMS22L Gene

Transcripts for MMS22L Gene

Unigene Clusters for MMS22L Gene

MMS22-like, DNA repair protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMS22L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MMS22L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMS22L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP5: - -
SP6:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for MMS22L Gene

GeneLoc Exon Structure for
MMS22L
ECgene alternative splicing isoforms for
MMS22L

Expression for MMS22L Gene

mRNA expression in normal human tissues for MMS22L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMS22L Gene

SOURCE GeneReport for Unigene cluster for MMS22L Gene Hs.444292

genes like me logo Genes that share expressions with MMS22L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MMS22L Gene

Orthologs for MMS22L Gene

This gene was present in the common ancestor of animals.

Orthologs for MMS22L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMS22L 35
  • 99.41 (n)
  • 99.36 (a)
MMS22L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMS22L 35
  • 89.07 (n)
  • 86.35 (a)
MMS22L 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMS22L 35
  • 89.82 (n)
  • 86.87 (a)
MMS22L 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mms22l 35
  • 83.62 (n)
  • 81 (a)
Mms22l 16
Mms22l 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMS22L 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mms22l 35
  • 83.76 (n)
  • 80.45 (a)
chicken
(Gallus gallus)
Aves MMS22L 35
  • 68.95 (n)
  • 62.02 (a)
MMS22L 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMS22L 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mms22l 35
  • 61.28 (n)
  • 58.64 (a)
zebrafish
(Danio rerio)
Actinopterygii mms22l 35
  • 54.93 (n)
  • 48.88 (a)
mms22l 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14803 36
  • 20 (a)
OneToOne
Species with no ortholog for MMS22L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMS22L Gene

ENSEMBL:
Gene Tree for MMS22L (if available)
TreeFam:
Gene Tree for MMS22L (if available)

Paralogs for MMS22L Gene

No data available for Paralogs for MMS22L Gene

Variants for MMS22L Gene

Sequence variations from dbSNP and Humsavar for MMS22L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs140706 -- 97,155,323(+) AAATT(-/GTTATT)ATTAC intron-variant
rs140707 -- 97,164,544(+) CTAAC(-/AAAAT)CAAGA intron-variant
rs717019 -- 97,182,739(+) ATCTA(C/T)CAACA intron-variant
rs717020 -- 97,182,743(+) ACCAA(C/T)AGGGT intron-variant
rs960098 -- 97,281,652(+) TTGTA(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMS22L Gene

Variant ID Type Subtype PubMed ID
nsv886426 CNV Gain 21882294
esv2485949 CNV Deletion 19546169
esv2541663 CNV Insertion 19546169

Relevant External Links for MMS22L Gene

HapMap Linkage Disequilibrium report
MMS22L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMS22L Gene

Disorders for MMS22L Gene

No disorders were found for MMS22L Gene.

No data available for UniProtKB/Swiss-Prot for MMS22L Gene

Publications for MMS22L Gene

  1. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. (PMID: 21055983) O'Donnell L. … Durocher D. (Mol. Cell 2010) 2 3 4
  2. Identification of the MMS22L-TONSL complex that promotes homologous recombination. (PMID: 21055984) Duro E. … Rouse J. (Mol. Cell 2010) 2 3 4
  3. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. (PMID: 21055985) O'Connell B.C. … Harper J.W. (Mol. Cell 2010) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MMS22L Gene

Sources for MMS22L Gene

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