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Aliases for MMRN2 Gene

Aliases for MMRN2 Gene

  • Multimerin 2 2 3 5
  • Elastin Microfibril Interfacer 3 2 3 4
  • Elastin Microfibril Interface Located Protein 3 3 4
  • EndoGlyx-1 P125/P140 Subunit 3 4
  • EMILIN-3 3 4
  • EMILIN3 3 4
  • EMILIN-Like Protein EndoGlyx-1 3
  • ENDOGLYX-1 3

External Ids for MMRN2 Gene

Previous HGNC Symbols for MMRN2 Gene


Previous GeneCards Identifiers for MMRN2 Gene

  • GC10M088361
  • GC10M088685
  • GC10M082549

Summaries for MMRN2 Gene

Entrez Gene Summary for MMRN2 Gene

  • This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

GeneCards Summary for MMRN2 Gene

MMRN2 (Multimerin 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Phospholipase-C Pathway. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is MMRN1.

UniProtKB/Swiss-Prot for MMRN2 Gene

  • Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMRN2 Gene

Genomics for MMRN2 Gene

Regulatory Elements for MMRN2 Gene

Enhancers for MMRN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MMRN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMRN2 Gene

86,935,540 bp from pter
86,969,953 bp from pter
34,414 bases
Minus strand

Genomic View for MMRN2 Gene

Genes around MMRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMRN2 Gene

Proteins for MMRN2 Gene

  • Protein details for MMRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q504V7
    • Q6P2N2

    Protein attributes for MMRN2 Gene

    949 amino acids
    Molecular mass:
    104409 Da
    Quaternary structure:
    • Heteromer of p110, p125, p140 and p200 subunits; disulfide-linked. Interacts with VEGFA.

neXtProt entry for MMRN2 Gene

Proteomics data for MMRN2 Gene at MOPED

Post-translational modifications for MMRN2 Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn 205, Asn 214, Asn 249, Asn 261, Asn 350, Asn 379, Asn 439, Asn 472, Asn 727, Asn 765, and Asn 845
  • Modification sites at PhosphoSitePlus

Other Protein References for MMRN2 Gene

No data available for DME Specific Peptides for MMRN2 Gene

Domains & Families for MMRN2 Gene

Gene Families for MMRN2 Gene

Protein Domains for MMRN2 Gene

Suggested Antigen Peptide Sequences for MMRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C1q domain.
  • Contains 1 C1q domain.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with MMRN2: view

Function for MMRN2 Gene

Molecular function for MMRN2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Animal Model Products

  • Taconic Biosciences Mouse Models for MMRN2

miRNA for MMRN2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMRN2 Gene

Localization for MMRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMRN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for MMRN2 Gene COMPARTMENTS Subcellular localization image for MMRN2 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with MMRN2: view

Pathways & Interactions for MMRN2 Gene

genes like me logo Genes that share pathways with MMRN2: view

Pathways by source for MMRN2 Gene

Interacting Proteins for MMRN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H8L6-MMRN2_HUMAN ENSP00000361097 for MMRN2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA 22020326
genes like me logo Genes that share ontologies with MMRN2: view

No data available for SIGNOR curated interactions for MMRN2 Gene

Drugs & Compounds for MMRN2 Gene

No Compound Related Data Available

Transcripts for MMRN2 Gene

Unigene Clusters for MMRN2 Gene

Multimerin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMRN2 Gene

No ASD Table

Relevant External Links for MMRN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMRN2 Gene

mRNA expression in normal human tissues for MMRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMRN2 Gene

This gene is overexpressed in Serum (30.0) and Urine (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMRN2 Gene

SOURCE GeneReport for Unigene cluster for MMRN2 Gene Hs.524479

mRNA Expression by UniProt/SwissProt for MMRN2 Gene

Tissue specificity: Endothelium.
genes like me logo Genes that share expression patterns with MMRN2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MMRN2 Gene

Orthologs for MMRN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMRN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MMRN2 35
  • 83.06 (n)
  • 76.73 (a)
MMRN2 36
  • 76 (a)
(Canis familiaris)
Mammalia MMRN2 35
  • 76.4 (n)
  • 67.01 (a)
MMRN2 36
  • 62 (a)
(Mus musculus)
Mammalia Mmrn2 35
  • 75.12 (n)
  • 66.95 (a)
Mmrn2 16
Mmrn2 36
  • 66 (a)
(Pan troglodytes)
Mammalia MMRN2 35
  • 99.37 (n)
  • 99.05 (a)
MMRN2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mmrn2 35
  • 75.37 (n)
  • 66.88 (a)
(Monodelphis domestica)
Mammalia MMRN2 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia MMRN2 36
  • 43 (a)
(Gallus gallus)
Aves MMRN2 35
  • 51.03 (n)
  • 40.21 (a)
MMRN2 36
  • 34 (a)
(Anolis carolinensis)
Reptilia MMRN2 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmrn2 35
  • 47.23 (n)
  • 36.81 (a)
(Danio rerio)
Actinopterygii mmrn2a 35
  • 41.67 (n)
  • 29.28 (a)
mmrn2a 36
  • 20 (a)
mmrn2b 36
  • 19 (a)
Species with no ortholog for MMRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMRN2 Gene

Gene Tree for MMRN2 (if available)
Gene Tree for MMRN2 (if available)

Paralogs for MMRN2 Gene

Paralogs for MMRN2 Gene Pseudogenes for MMRN2 Gene

genes like me logo Genes that share paralogs with MMRN2: view

Variants for MMRN2 Gene

Sequence variations from dbSNP and Humsavar for MMRN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_019801 -
rs4934281 - 86,942,593(+) GCCGT(C/G)AAGGG reference, missense
VAR_036362 A colorectal cancer sample
rs36073867 - 86,937,100(-) GCCAG(C/G)TTTTC reference, missense
rs34587013 - 86,936,865(-) CAACG(C/G)TCTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMRN2 Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
dgv311e1 CNV Complex 17122850
dgv312e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
nsv517487 CNV Gain+Loss 19592680
nsv7482 CNV Insertion 18451855
nsv470969 CNV Loss 18288195
nsv895858 CNV Loss 21882294
nsv895859 CNV Loss 21882294
esv24935 CNV Loss 19812545
esv33376 CNV Loss 17666407

Variation tolerance for MMRN2 Gene

Residual Variation Intolerance Score: 7.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.97; 84.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMRN2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMRN2 Gene

Disorders for MMRN2 Gene

Relevant External Links for MMRN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MMRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMRN2 Gene

Publications for MMRN2 Gene

  1. Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. (PMID: 11559704) Christian S. … Lenter M.C. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. N-glycoprotein profiling of lung adenocarcinoma pleural effusions by shotgun proteomics. (PMID: 18327805) Soltermann A. … Moch H. (Cancer 2008) 3 23
  3. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. (PMID: 25745997) Noy P.J. … Bicknell R. (Oncogene 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for MMRN2 Gene

Sources for MMRN2 Gene