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Aliases for MMRN2 Gene

Aliases for MMRN2 Gene

  • Multimerin 2 2 3
  • Elastin Microfibril Interfacer 3 2 3 4
  • Elastin Microfibril Interface Located Protein 3 3 4
  • EndoGlyx-1 P125/P140 Subunit 3 4
  • EMILIN-3 3 4
  • EMILIN3 3 4
  • EMILIN-Like Protein EndoGlyx-1 3
  • Multimerin-2 3
  • ENDOGLYX-1 3

External Ids for MMRN2 Gene

Previous HGNC Symbols for MMRN2 Gene

  • EMILIN3

Previous GeneCards Identifiers for MMRN2 Gene

  • GC10M088361
  • GC10M088685
  • GC10M082549

Summaries for MMRN2 Gene

Entrez Gene Summary for MMRN2 Gene

  • This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

GeneCards Summary for MMRN2 Gene

MMRN2 (Multimerin 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. An important paralog of this gene is MMRN1.

UniProtKB/Swiss-Prot for MMRN2 Gene

  • Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMRN2 Gene

Genomics for MMRN2 Gene

Regulatory Elements for MMRN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMRN2 Gene

Start:
86,935,540 bp from pter
End:
86,970,240 bp from pter
Size:
34,701 bases
Orientation:
Minus strand

Genomic View for MMRN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMRN2 Gene

Proteins for MMRN2 Gene

  • Protein details for MMRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8L6-MMRN2_HUMAN
    Recommended name:
    Multimerin-2
    Protein Accession:
    Q9H8L6
    Secondary Accessions:
    • Q504V7
    • Q6P2N2

    Protein attributes for MMRN2 Gene

    Size:
    949 amino acids
    Molecular mass:
    104409 Da
    Quaternary structure:
    • Heteromer of p110, p125, p140 and p200 subunits; disulfide-linked. Interacts with VEGFA.

neXtProt entry for MMRN2 Gene

Proteomics data for MMRN2 Gene at MOPED

Post-translational modifications for MMRN2 Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn205, Asn214, Asn249, Asn261, Asn350, Asn379, Asn439, Asn472, Asn727, Asn765, and Asn845
  • Modification sites at PhosphoSitePlus

Other Protein References for MMRN2 Gene

No data available for DME Specific Peptides for MMRN2 Gene

Domains for MMRN2 Gene

Gene Families for MMRN2 Gene

HGNC:
  • EMID :EMI domain containing

Protein Domains for MMRN2 Gene

Suggested Antigen Peptide Sequences for MMRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8L6

UniProtKB/Swiss-Prot:

MMRN2_HUMAN :
  • Q9H8L6
Domain:
  • Contains 1 C1q domain.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with MMRN2: view

Function for MMRN2 Gene

Molecular function for MMRN2 Gene

UniProtKB/Swiss-Prot Function: Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Gene Ontology (GO) - Molecular Function for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 22020326
genes like me logo Genes that share ontologies with MMRN2: view

Animal Model Products

miRNA for MMRN2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMRN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMRN2 Gene

Localization for MMRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMRN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMRN2 Gene COMPARTMENTS Subcellular localization image for MMRN2 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 11559704
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MMRN2: view

Pathways for MMRN2 Gene

genes like me logo Genes that share pathways with MMRN2: view

Pathways by source for MMRN2 Gene

Interacting Proteins for MMRN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361097%0d%0a9606.ENSP00000447173%0d%0a
Selected Interacting proteins: Q9H8L6-MMRN2_HUMAN ENSP00000361097 for MMRN2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA 22020326
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22020326
genes like me logo Genes that share ontologies with MMRN2: view

Transcripts for MMRN2 Gene

Unigene Clusters for MMRN2 Gene

Multimerin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMRN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMRN2 Gene

No ASD Table

Relevant External Links for MMRN2 Gene

GeneLoc Exon Structure for
MMRN2
ECgene alternative splicing isoforms for
MMRN2

Expression for MMRN2 Gene

mRNA expression in normal human tissues for MMRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MMRN2 Gene

SOURCE GeneReport for Unigene cluster for MMRN2 Gene Hs.524479

mRNA Expression by UniProt/SwissProt for MMRN2 Gene

Q9H8L6-MMRN2_HUMAN
Tissue specificity: Endothelium.
genes like me logo Genes that share expressions with MMRN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MMRN2 Gene

Orthologs for MMRN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMRN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMRN2 35
  • 99.37 (n)
  • 99.05 (a)
MMRN2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMRN2 35
  • 83.06 (n)
  • 76.73 (a)
MMRN2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMRN2 35
  • 76.4 (n)
  • 67.01 (a)
MMRN2 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmrn2 35
  • 75.12 (n)
  • 66.95 (a)
Mmrn2 16
Mmrn2 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMRN2 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMRN2 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmrn2 35
  • 75.37 (n)
  • 66.88 (a)
chicken
(Gallus gallus)
Aves MMRN2 35
  • 51.03 (n)
  • 40.21 (a)
MMRN2 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMRN2 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmrn2 35
  • 47.23 (n)
  • 36.81 (a)
zebrafish
(Danio rerio)
Actinopterygii mmrn2a 35
  • 41.67 (n)
  • 29.28 (a)
mmrn2a 36
  • 20 (a)
ManyToMany
mmrn2b 36
  • 19 (a)
ManyToMany
Species with no ortholog for MMRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMRN2 Gene

ENSEMBL:
Gene Tree for MMRN2 (if available)
TreeFam:
Gene Tree for MMRN2 (if available)

Paralogs for MMRN2 Gene

Paralogs for MMRN2 Gene

Pseudogenes.org Pseudogenes for MMRN2 Gene

genes like me logo Genes that share paralogs with MMRN2: view

Variants for MMRN2 Gene

Sequence variations from dbSNP and Humsavar for MMRN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs746677 -- 86,940,881(+) CTCCC(A/G)GGACC intron-variant
rs748026 -- 86,964,703(-) TCATA(C/T)AGGCC intron-variant
rs873110 -- 86,964,862(-) AGAGG(A/G)CCCTG intron-variant
rs1240389 -- 86,966,423(-) ttttt(C/T)ccttt intron-variant
rs1240390 -- 86,966,227(-) GTTAC(C/T)CATtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMRN2 Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
dgv311e1 CNV Complex 17122850
dgv312e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
nsv517487 CNV Gain+Loss 19592680
nsv7482 CNV Insertion 18451855
nsv470969 CNV Loss 18288195
nsv895858 CNV Loss 21882294
nsv895859 CNV Loss 21882294
esv24935 CNV Loss 19812545
esv33376 CNV Loss 17666407

Relevant External Links for MMRN2 Gene

HapMap Linkage Disequilibrium report
MMRN2
Human Gene Mutation Database (HGMD)
MMRN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMRN2 Gene

Disorders for MMRN2 Gene

No disorders were found for MMRN2 Gene.

No data available for UniProtKB/Swiss-Prot for MMRN2 Gene

Publications for MMRN2 Gene

  1. Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. (PMID: 11559704) Christian S. … Lenter M.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. N-glycoprotein profiling of lung adenocarcinoma pleural effusions by shotgun proteomics. (PMID: 18327805) Soltermann A. … Moch H. (Cancer 2008) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4

Products for MMRN2 Gene

Sources for MMRN2 Gene

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