Aliases for MMRN2 Gene
External Ids for MMRN2 Gene
Previous HGNC Symbols for MMRN2 Gene
Previous GeneCards Identifiers for MMRN2 Gene
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
GeneCards Summary for MMRN2 Gene
MMRN2 (Multimerin 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Phospholipase-C Pathway. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is MMRN1.
UniProtKB/Swiss-Prot for MMRN2 Gene
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.