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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMRN1 Gene

protein-coding   GIFtS: 56
GCID: GC04P090800

multimerin 1

(Previous name: multimerin )
(Previous symbol: MMRN)
 Explore 24 diseases affiliated with
MMRN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MMRN1    

Aliases
for MMRN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Multimerin 11 2     Endothelial Cell Multimerin2 3
ECM1 2 3     EMILIN-42 3
EMILIN41 2 3     Multimerin1
MMRN1 2 3     Glycoprotein Ia*2
GPIa*1 2     Multimerin-11
Elastin Microfibril Interface Located Protein 42 3     GPIA*3
Elastin Microfibril Interfacer 42 3     

External Ids:    HGNC: 71781   Entrez Gene: 229152   Ensembl: ENSG000001387227   OMIM: 6014565   UniProtKB: Q132013   

Export aliases for MMRN1 gene to outside databases

Previous GC identifers: GC04P091275 GC04P091173 GC04P091035 GC04P086567


Summaries
for MMRN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MMRN1:
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of
subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor
V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an
extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder
(factor V Quebec) were found to have a deficiency of platelet multimerin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201
Function: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of
factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent
thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may
function as an extracellular matrix or adhesive protein

Gene Wiki entry for MMRN1


Genomic Views
for MMRN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMRN1 gene promoter:
         GR   CUTL1   IRF-1   RORalpha2   CREB   PPAR-gamma1   S8   deltaCREB   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMRN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMRN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22

MMRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMRN1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P090800:  view genomic region     (about GC identifiers)

Start:
 90,800,683 bp from pter      End:
 90,875,780 bp from pter
Size:
 75,098 bases      Orientation:
 plus strand

Proteins
for MMRN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201 (See protein sequence)
Recommended Name: Multimerin-1 precursor  
Size: 1228 amino acids; 138110 Da
Subunit: Multimeric. Composed of varying sized, disulfide-linked multimers, the smallest of which is a homotrimer.
Proteolysis of the promultimerin in the N-terminal region, leads to the mature p155 form that is stored in platelets.
Interacts with factor V/Va
Subcellular location: Secreted (Potential)
Secondary accessions: Q4W5L1 Q6P3T8 Q6ZUL9
Alternative splicing: 2 isoforms:  Q13201-1   Q13201-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MMRN1: NX_Q13201

Post-translational modifications:

  • The N-terminus is blocked1
  • Extensively N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13201

    • MMRN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031377.2  
    ENSEMBL proteins: 
     ENSP00000378431   ENSP00000426461   ENSP00000264790   ENSP00000378432  
    Reactome Protein details: Q13201
    Human Recombinant Protein Products: 
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    Novus Biologicals MMRN1 Lysate
    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for MMRN1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0031093platelet alpha granule lumen TAS--


    MMRN1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MMRN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MMRN1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000742 EG-like_dom
     IPR011489 EMI_domain
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR013032 EGF-like_CS
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13201

    ProtoNet protein and cluster: Q13201

    4 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001073 Complement C1q protein
    IPB006210 Type I EGF
    IPB011489 EMI


    UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 EMI domain


    Function
    for MMRN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201
    Function: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of
    factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent
    thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may
    function as an extracellular matrix or adhesive protein

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MMRN1 (see all 15):
    hsa-miR-3671 hsa-miR-579 hsa-miR-576-3p hsa-miR-577 hsa-miR-495 hsa-miR-607 hsa-miR-7-2* hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmid: MMRN1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MMRN1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMRN1 (see all 3)
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    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMRN1

    1 GenomeRNAi human phenotype for MMRN1:
     Increased homologous recombina 


    Pathways & Interactions
    for MMRN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for MMRN1
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+



    MMRN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMRN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for MMRN1 (Q132013 ENSP000002647904) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    F5P122593, ENSP000003567714I2D: score=1 STRING: ENSP00000356771
    APCP250543I2D: score=1 
    A2MENSP000003239294STRING: ENSP00000323929
    ALBENSP000002958974STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007155cell adhesion TAS9189649
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--


    MMRN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MMRN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMRN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MMRN1
    5 Novoseek chemical compound relationships for MMRN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 37.3 1 2186487 (1)
    okt3 35.9 2 9840680 (1), 10736113 (1)
    fibrinogen 26.5 4 8652809 (2), 9028947 (1), 16268476 (1)
    epinephrine 17.7 4 9028947 (2), 8652809 (2)
    leucine 1.42 1 10625608 (1)

    Search CenterWatch for drugs/clinical trials and news about MMRN1 

    Transcripts
    for MMRN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MMRN1 gene: 
    NM_007351.2  

    Unigene Cluster for MMRN1:

    Multimerin 1
    Hs.268107  [show with all ESTs]
    Unigene Representative Sequence: NM_007351
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394980(uc010iku.3 uc003hst.3 uc011cds.2) ENST00000508372
    ENST00000506328 ENST00000264790 ENST00000394981

    miRNA
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    hsa-miR-3671 hsa-miR-579 hsa-miR-576-3p hsa-miR-577 hsa-miR-495 hsa-miR-607 hsa-miR-7-2* hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmid: MMRN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMRN1
    OriGene shRNA RFP: MMRN1
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMRN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMRN1

    Additional cDNA sequence: 

    AK125557.1 AK302421.1 AK313566.1 BC063848.1 U27109.1 

    5 DOTS entries:

    DT.216129  DT.101980775  DT.121240292  DT.99962516  DT.97824620 

    24/87 AceView cDNA sequences (see all 87):

    AA969675 AA423867 BM127039 BC063848 BX117547 AA187212 AI129673 AA344360 
    BM129302 AI140846 CF541032 BQ880717 AA382782 W76641 AK125557 NM_007351 
    U27109 AA913011 AA257095 AA677551 BE501642 AA344284 AI422557 AA778014 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MMRN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                            -                     
    SP2:                                                                  


    ECgene alternative splicing isoforms for MMRN1

    Expression
    for MMRN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTAAAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MMRN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Early Embryo (Zygote)Zygote2-Cell EmbryoEarly Embryo
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    AdiposeVisceral White AdiposeAdipose
    BrainMeningesBrain
    KidneyEpithelial TubuleKidney
    KidneyInterstitial StromaKidney
    KidneyMetanephric MesenchymeKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium

    See MMRN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMRN1

    SOURCE GeneReport for Unigene cluster: Hs.268107

    UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201
    Tissue specificity: Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and
    endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to
    megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular
    tissues such as placenta, lung, and liver

        SABiosciences Custom PCR Arrays for MMRN1
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    In Situ
    Assay Products:     
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    Orthologs
    for MMRN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MMRN1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MMRN11 multimerin 1 60.65(n)
    49.4(a)    		   428741  XM_426299.3  XP_426299.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MMRN16
    		 --
    		 48(a)
    		 1 ↔ 1
    		 5(46344123-46385116)
    zebrafish
    (Danio rerio)    		 Actinopterygii mmrn2a6
    mmrn2b6
    		 multimerin 2b
    		 14(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 13(22759192-22786366)
    12(27505876-27522325)


    ENSEMBL Gene Tree for MMRN1 (if available)
    TreeFam Gene Tree for MMRN1 (if available) 

    Paralogs
    for MMRN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMRN1 gene
    MMRN22  
    1 SIMAP similar gene for MMRN1 using alignment to 2 protein entries:     MMRN1_HUMAN (see all proteins):
    SNED1

    MMRN1 for paralogs           About GeneDecksing



    Genomic Variants
    for MMRN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MMRN1
         1 CNV: 51489
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMRN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MMRN1

    Disorders / Diseases
    for MMRN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MMRN1 for disorders           About GeneDecksing

    OMIM gene information: 601456    OMIM disorders: --

    UniProtKB/Swiss-Prot: MMRN1_HUMAN, Q13201
  • Note=Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is
    • associated with an autosomal dominant bleeding disorder (factor V Quebec)

    20/24 diseases for MMRN1 (see all 24):    About MalaCards
    bleeding disorder    quebec platelet disorder    neonatal alloimmune thrombocytopenia    von willebrand's disease
    polycythemia vera    myocardial infarction    atrial fibrillation    thrombocytopenia
    polycythemia    vascular disease    diabetic retinopathy    thrombosis
    periodontitis    periodontal disease    hepatitis b    parkinson's disease
    vaginitis    asthma    colorectal cancer    hepatitis

    10/12 Novoseek disease relationships for MMRN1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    quebec platelet disorder 88.6 2 8652809 (2)
    platelet disorder 52.7 2 8652809 (2)
    coagulopathy 31.8 2 9028947 (1), 8652809 (1)
    stroke 16.8 5 17890945 (1), 18608122 (1), 10884464 (1), 11703818 (1)
    thrombosis 16.2 2 17164499 (1), 16380674 (1)
    vascular diseases 15.2 1 10583259 (1)
    thrombocytopenia 8.92 1 16525577 (1)
    myocardial infarction 7.11 3 17164499 (1), 11703818 (1), 17157856 (1)
    asthma 0 4 11236132 (2), 16456242 (2)
    inflammation 0 1 16456242 (1)

    Genetic Association Database (GAD): MMRN1
    Human Genome Epidemiology (HuGE) Navigator: MMRN1 (3 documents)

    Export disorders for MMRN1 gene to outside databases

    Publications
    for MMRN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMRN1 gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with MMRN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cDNA sequence of human endothelial cell multimerin. A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X. (PubMed id 7629143)1, 2, 3, 9 Hayward C.P.M.... Kelton J.G. (1995)
    2. Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation. (PubMed id 19132231)1, 2, 9 Jeimy S.B.... Hayward C.P.M. (2008)
    3. Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3. (PubMed id 16363244)1, 2, 9 Adam F....Hayward C.P. (2005)
    4. Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line. (PubMed id 8514871)1, 2, 9 Hayward C.P.M.... Kelton J.G. (1993)
    5. Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms. (PubMed id 9798985)1, 2, 9 Polgar J....Clemetson K.J. (1998)
    6. An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect. (PubMed id 8652809)1, 2, 9 Hayward C.P.M.... Kelton J.G. (1996)
    7. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2, 9 Lewandrowski U.... Sickmann A. (2006)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    9. Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. (PubMed id 15849733)1, 4 Mangold E....Propping P. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for MMRN1 gene

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    Genome Databases showing MMRN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22915 HGNC: 7178 AceView: MMRN1 Ensembl:ENSG00000138722 euGenes: HUgn22915
    ECgene: MMRN1 H-InvDB: MMRN1

    Other Databases showing MMRN1 gene

    (According to HUGE)
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    Specialized Databases showing MMRN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for MMRN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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