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Aliases for MMP9 Gene

Aliases for MMP9 Gene

  • Matrix Metallopeptidase 9 2 3 5
  • Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 2 3
  • EC 3.4.24.35 4 61
  • CLG4B 3 4
  • MMP-9 3 4
  • GELB 3 4
  • Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 3
  • Matrix Metalloproteinase-9 3
  • 92 KDa Type IV Collagenase 4
  • Macrophage Gelatinase 3
  • Type V Collagenase 3
  • 92 KDa Gelatinase 4
  • Gelatinase B 4
  • EC 3.4.24 61
  • MANDP2 3

External Ids for MMP9 Gene

Previous HGNC Symbols for MMP9 Gene

  • CLG4B

Previous GeneCards Identifiers for MMP9 Gene

  • GC20P044366
  • GC20P045275
  • GC20P045322
  • GC20P044070
  • GC20P044637
  • GC20P041378

Summaries for MMP9 Gene

Entrez Gene Summary for MMP9 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

CIViC summary for MMP9 Gene

GeneCards Summary for MMP9 Gene

MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include Metaphyseal Anadysplasia 2 and Metaphyseal Anadysplasia. Among its related pathways are Validated targets of C-MYC transcriptional activation and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include identical protein binding and metalloendopeptidase activity. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP9 Gene

  • May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Tocris Summary for MMP9 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP9 Gene

Genomics for MMP9 Gene

Regulatory Elements for MMP9 Gene

Enhancers for MMP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G046002 1.4 FANTOM5 Ensembl ENCODE 0.7 -4.3 -4308 3.6 BCOR ZMYM3 MAX ZFHX2 EED ETV6 IKZF2 CHD2 MTA2 CBFB CD40 ZNF335 NCOA5 SLC12A5 PCIF1 PLTP MMP9 FTLP1
GH20G046007 1 Ensembl ENCODE 0.7 -0.4 -408 1.4 BCOR ZMYM3 MAX NFXL1 ZIC2 RELA ZNF664 ZNF316 EGR1 EED MMP9 FTLP1
GH20G046010 1 Ensembl ENCODE 0.7 +2.6 2558 2.5 CTCF AGO1 DDX20 ZKSCAN1 ZFHX2 POLR2A EGR1 NFYB PRDM10 KLF8 SLC12A5 MMP9
GH20G045998 1.4 FANTOM5 Ensembl ENCODE 0.4 -10.1 -10141 1.0 CTCF PKNOX1 TAL1 MAX FOSL1 TCF12 EGR1 NCOR1 ADNP TRIM24 SLC12A5 SLC12A5-AS1 NCOA5 ZNF335 CD40 PLTP PCIF1 MMP9 FTLP1
GH20G046013 1.3 Ensembl ENCODE 0.4 +5.0 5048 1.3 HDGF PKNOX1 CREB3L1 AGO1 ARID4B DMAP1 ZNF2 ZNF143 DEK ZNF263 SLC12A5 MMP9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP9 Gene

Chromosome:
20
Start:
46,008,908 bp from pter
End:
46,016,561 bp from pter
Size:
7,654 bases
Orientation:
Plus strand

Genomic View for MMP9 Gene

Genes around MMP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP9 Gene

Proteins for MMP9 Gene

  • Protein details for MMP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14780-MMP9_HUMAN
    Recommended name:
    Matrix metalloproteinase-9
    Protein Accession:
    P14780
    Secondary Accessions:
    • B2R7V9
    • Q3LR70
    • Q8N725
    • Q9H4Z1
    • Q9UCJ9
    • Q9UCL1
    • Q9UDK2

    Protein attributes for MMP9 Gene

    Size:
    707 amino acids
    Molecular mass:
    78458 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
    Miscellaneous:
    • In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.

    Three dimensional structures from OCA and Proteopedia for MMP9 Gene

neXtProt entry for MMP9 Gene

Selected DME Specific Peptides for MMP9 Gene

P14780:
  • PRCGVPD
  • LWCATTSN
  • GLLAHAFPPG
  • LFLVAAHE
  • VAAHEFGHALGL
  • FFFSGRQ
  • DGYPFDG
  • VAAHEFGH
  • LDKLGLG
  • IGNQLYL
  • GLLAHAF
  • GGNSAGE
  • KWGFCPD

Post-translational modifications for MMP9 Gene

  • N- and O-glycosylated.
  • Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  • Glycosylation at posLast=3838, Asn120, and posLast=127127
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Abcam assays for MMP9

Domains & Families for MMP9 Gene

Gene Families for MMP9 Gene

Suggested Antigen Peptide Sequences for MMP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14780

UniProtKB/Swiss-Prot:

MMP9_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP9: view

Function for MMP9 Gene

Molecular function for MMP9 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of gelatin types I and V and collagen types IV and V.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
UniProtKB/Swiss-Prot Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
UniProtKB/Swiss-Prot Induction:
Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Expression induced by M.bovis MPB83 (at protein level) (PubMed:20800577).

Enzyme Numbers (IUBMB) for MMP9 Gene

Gene Ontology (GO) - Molecular Function for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 19022250
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 2251898
GO:0005518 collagen binding TAS 2551898
genes like me logo Genes that share ontologies with MMP9: view
genes like me logo Genes that share phenotypes with MMP9: view

Human Phenotype Ontology for MMP9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MMP9 Gene

MGI Knock Outs for MMP9:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP9

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP9
  • Applied Biological Materials Clones for MMP9

No data available for Transcription Factor Targets and HOMER Transcription for MMP9 Gene

Localization for MMP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP9 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP9 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 2
peroxisome 2
lysosome 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 2551898
GO:0031012 extracellular matrix IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MMP9: view

Pathways & Interactions for MMP9 Gene

genes like me logo Genes that share pathways with MMP9: view

SIGNOR curated interactions for MMP9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006508 proteolysis IDA 2551898
GO:0007566 embryo implantation IEA --
genes like me logo Genes that share ontologies with MMP9: view

Drugs & Compounds for MMP9 Gene

(106) Drugs for MMP9 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor, Target MMPs inhibitor,board spectrum 4
Minocycline Approved, Investigational Pharma Target, inhibitor 231
Captopril Approved Pharma Inhibition, Inhibitor, Target, inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 34
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 519
Zinc Approved Pharma 2296

(60) Additional Compounds for MMP9 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP9 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9

(7) ApexBio Compounds for MMP9 Gene

Compound Action Cas Number
7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide Substrate of matrix metalloproteinases assay 140430-53-1
Batimastat (BB-94) MMP inhibitor 130370-60-4
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent 10592-13-9
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
Marimastat MMPs inhibitor,board spectrum 154039-60-8
Phosphoramidon Disodium Salt 164204-38-0
SB-3CT gelatinases inhibitor, potent and selective 292605-14-2
genes like me logo Genes that share compounds with MMP9: view

Drug Products

Transcripts for MMP9 Gene

mRNA/cDNA for MMP9 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP9 Gene

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP9
  • Applied Biological Materials Clones for MMP9

Alternative Splicing Database (ASD) splice patterns (SP) for MMP9 Gene

No ASD Table

Relevant External Links for MMP9 Gene

GeneLoc Exon Structure for
MMP9
ECgene alternative splicing isoforms for
MMP9

Expression for MMP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP9 Gene

This gene is overexpressed in Whole Blood (x46.3).

Protein differential expression in normal tissues from HIPED for MMP9 Gene

This gene is overexpressed in Neutrophil (45.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP9 Gene



Protein tissue co-expression partners for MMP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP9 Gene:

MMP9

SOURCE GeneReport for Unigene cluster for MMP9 Gene:

Hs.297413

mRNA Expression by UniProt/SwissProt for MMP9 Gene:

P14780-MMP9_HUMAN
Tissue specificity: Produced by normal alveolar macrophages and granulocytes.

Evidence on tissue expression from TISSUES for MMP9 Gene

  • Blood(5)
  • Bone marrow(3.4)
  • Lung(3.4)
  • Intestine(3.3)
  • Lymph node(3.3)
  • Heart(3.1)
  • Nervous system(3.1)
  • Liver(2.9)
  • Muscle(2.9)
  • Spleen(2.8)
  • Skin(2.7)
  • Bone(2.6)
  • Kidney(2.5)
  • Eye(2.4)
  • Stomach(2.2)
  • Pancreas(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP9 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with MMP9: view

Primer Products

Orthologs for MMP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP9 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia MMP9 34
  • 84.37 (n)
MMP-9 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP9 34 35
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Mmp9 34
  • 78.77 (n)
mouse
(Mus musculus)
Mammalia Mmp9 34 16 35
  • 78.36 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP9 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MMP9 34 35
  • 67.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494738 34
  • 60.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69080 34
zebrafish
(Danio rerio)
Actinopterygii mmp9 34 35
  • 60.77 (n)
wufb02g06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10476 34
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 35
  • 22 (a)
ManyToMany
zmp-1 35
  • 21 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45040 34
  • 46.18 (n)
Species where no ortholog for MMP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP9 Gene

ENSEMBL:
Gene Tree for MMP9 (if available)
TreeFam:
Gene Tree for MMP9 (if available)

Paralogs for MMP9 Gene

Paralogs for MMP9 Gene

(1) SIMAP similar genes for MMP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP9: view

Variants for MMP9 Gene

Sequence variations from dbSNP and Humsavar for MMP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs121434556 Pathogenic 46,008,928(+) CACCA(A/C/T)GAGCC reference, missense
rs1805088 Likely benign 46,008,985(+) TGCTG(C/T)CCCCA reference, missense
rs28763885 Likely benign 46,008,971(+) CTGGG(C/T)TGCTG reference, synonymous-codon
rs28763886 Likely benign 46,011,209(+) GGGCC(A/G)CTCCT reference, missense
rs3918257 Likely benign 46,013,244(+) CCGTG(A/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP9 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV loss 17160897

Variation tolerance for MMP9 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.70; 97.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP9 Gene

Human Gene Mutation Database (HGMD)
MMP9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP9 Gene

Disorders for MMP9 Gene

MalaCards: The human disease database

(173) MalaCards diseases for MMP9 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
metaphyseal anadysplasia 2
  • mandp2
metaphyseal anadysplasia
  • early-onset regressive form of metaphyseal dysplasia
middle ear squamous cell carcinoma
  • epidermoid carcinoma of the middle ear
eosinophilic meningitis
villonodular synovitis
  • pigmented villonodular synovitis
- elite association - COSMIC cancer census association via MalaCards
Search MMP9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP9_HUMAN
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. {ECO:0000269 PubMed:19615667}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MMP9

Genetic Association Database (GAD)
MMP9
Human Genome Epidemiology (HuGE) Navigator
MMP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP9
genes like me logo Genes that share disorders with MMP9: view

No data available for Genatlas for MMP9 Gene

Publications for MMP9 Gene

  1. Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. (PMID: 20184534) Wu S. … Ko Y.L. (Clin. Chem. Lab. Med. 2010) 3 22 46 64
  2. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y. … Ikegawa S. (Am. J. Hum. Genet. 2008) 3 4 46 64
  3. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. (PMID: 17033924) Lei H. … FAPrsti A. (Breast Cancer Res. Treat. 2007) 3 22 46 64
  4. Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer. (PMID: 17208328) Rollin J. … Gruel Y. (Lung Cancer 2007) 3 22 46 64
  5. Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (PMID: 15316122) Hulkkonen J. … LehtimAoki T. (Rheumatology (Oxford) 2004) 3 22 46 64

Products for MMP9 Gene

  • Addgene plasmids for MMP9

Sources for MMP9 Gene

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