Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP9 Gene

protein-coding GIFtS: 73
GCID: GC20P044637

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase,...

(Previous names: matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase,...)
(Previous symbol: CLG4B)

Explore 417 diseases affiliated with
MMP9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase)¹ ²		MANDP2² ⁵
CLG4B¹ ² ³ ⁵		Matrix Metalloproteinase 9 (Gelatinase B, 92kD Gelatinase, 92kD Type IV Collagenase)¹
Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase)¹ ²		Macrophage Gelatinase²
92 KDa Gelatinase² ³		Matrix Metalloproteinase-9²
92 KDa Type IV Collagenase² ³		Type V Collagenase²
GELB² ³		Gelatinase B³
MMP-9² ³		EC 3.4.24⁸
EC 3.4.24.35³ ⁸

External Ids:	HGNC: 7176¹	Entrez Gene: 4318²	Ensembl: ENSG00000100985⁷	OMIM: 120361⁵	UniProtKB: P14780³

Export aliases for MMP9 gene to outside databases

Previous GC identifers: GC20P044366 GC20P045275 GC20P045322 GC20P044070 GC20P041378

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP9:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in

rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from

bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could

play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen

into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but

not laminin or Pz-peptide

summary for MMP9:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP9 gene promoter:
Max USF1 USF-1 NRSF form 1 USF2 USF-1:USF-2 NRSF form 2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP9 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2-q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12-q13

MMP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP9 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P044637: view genomic region (about GC identifiers)

Start:	44,637,547 bp from pter	End:	44,645,200 bp from pter
Size:	7,654 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780 (See protein sequence)

Recommended Name: Matrix metalloproteinase-9 precursor

Size: 707 amino acids; 78458 Da

Cofactor: Binds 2 zinc ions per subunit

Cofactor: Binds 3 calcium ions per subunit

Subunit: Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein.

Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

Miscellaneous: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might

constitute a useful marker of disease status

6/10 PDB 3D structures from and Proteopedia for MMP9 (see all 10):

1GKC (3D)

1GKD (3D)

1ITV (3D)

1L6J (3D)

1LKG (3D)

2OVX (3D)

Secondary accessions: B2R7V9 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1 Q9UDK2

Explore the universe of human proteins at neXtProt for MMP9: NX_P14780

Post-translational modifications:

Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields

the 82 kDa matrix metalloproteinase-9¹

N- and O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14780

4/13 DME Specific Peptides for MMP9 (P14780) (see all 13)

FFFSGRQ

GLLAHAF

IGNQLYL

DGYPFDG

MMP9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004985.2

ENSEMBL proteins:

ENSP00000361405

Reactome Protein details: P14780
Human Recombinant Protein Products for MMP9:

	EMD Millipore Purified and/or Recombinant MMP9 Protein
	R&D Systems Recombinant & Natural Proteins for MMP9 (MMP-9)
	Enzo Life Sciences proteins for MMP9
	OriGene Purified Protein: MMP9 OriGene Protein Over-expression Lysate: MMP9 OriGene Custom Protein Services for MMP9
	GenScript Custom Purified and Recombinant Proteins Services for MMP9
	Novus Biologicals MMP9 Proteins Novus Biologicals MMP9 Lysate
	Sino Biological Recombinant Protein for MMP9
	ProSpec Recombinant Protein for MMP9
	Uscn Proteins for MMP9

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	2251898
GO:0043234	protein complex	--	--

MMP9 for ontologies About GeneDecksing

MMP9 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP9
	R&D Systems Antibodies for MMP9 (MMP-9)
	Cell Signaling Technology (CST) Antibodies for MMP9
	OriGene Antibodies (see all 3): MMP9 OriGene Custom Antibody Services for MMP9
	GenScript Custom Superior Antibodies Services for MMP9
	Novus Biologicals MMP9 Antibodies
	Abcam antibodies for MMP9
	Uscn Antibodies for MMP9
	ThermoFisher Antibody for MMP9

Assay Products for MMP9:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP9 (MMP-9) (see first)
	R&D Systems ELISpot Kits & Development Modules for MMP9 (MMP-9)
	R&D Systems Multiplex/Array Assay Kits & Reagents for MMP9 (MMP-9)
	R&D Systems Kinase Activity Assays & Reagents for MMP9 (MMP-9)
	See all other biochemical assays at R&D Systems
	GenScript MMP9-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP9
	Uscn ELISAs and CLIAs for MMP9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP9 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P14780

ProtoNet protein and cluster: P14780

4 Blocks protein families:

IPB000562 Type II fibronectin collagen-binding domain

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 3 fibronectin type-II domains

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MMP9_HUMAN, P14780

Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could

play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen

into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but

not laminin or Pz-peptide

Catalytic activity: Cleavage of gelatin types I and V and collagen types IV and V

Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1

Induction: Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via

the JNK signaling pathway in colorectal tumor cells

Genatlas biochemistry entry for MMP9:

matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast

cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and

apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the

migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of

myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse

type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with

neovascularization),may be also involved in the severity of coronary atherosclerosis

Enzyme Numbers (IUBMB): EC 3.4.24.35¹ ² EC 3.4.24²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	--	--
GO:0004222	metalloendopeptidase activity	IDA	9789069
GO:0005515	protein binding	IPI	--
GO:0005518	collagen binding	TAS	2251898
GO:0008233	peptidase activity	--	--

MMP9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MMP9:

Increased gamma-H2AX phosphory

15/19 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mmp9) (see all 19):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail
mortality/aging	muscle	nervous system	renal/urinary system	reproductive system

MMP9 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for MMP9: Mmp9^tm1Itoh Mmp9^tm1Tvu Mmp9^tm1Arnd Mmp9^tm1Amr

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MMP9

miRNA Products:		miRTarBase miRNAs that target MMP9: hsa-mir-451 (MIRT005743)

		OriGene 3'-UTR Clone: MMP9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP9
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP9:
		hsa-miR-1224-3p hsa-miR-3713
		SwitchGear 3'UTR luciferase reporter plasmid: MMP9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP9 (see all 7) OriGene shRNA RFP: MMP9 OriGene siRNA: MMP9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP9
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP9

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MMP9
			Sirion Biotech Customized adenovirus for overexpression of MMP9 Sirion Biotech Customized adenovirus for potent knockdown of MMP9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP9 (NM_004994)
		Sino Biological Human cDNA Clone for MMP9
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP9
		Search LifeMap BioReagents cell lines for MMP9
		Sirion Biotech Customized stable knockdown cell line services for MMP9 Sirion Biotech Customized inducible knockdown cell line services for MMP9 Sirion Biotech Customized stable overexpressing cell line services for MMP9 Sirion Biotech Customized inducible overexpressing cell line services for MMP9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Assembly of collagen fibrils and other multimeric structures	0.65

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

Integrin Pathway

	UPA-UPAR Pathway	0.51			Inhibition of Angiogenesis by TSP1	0.37
	Transendothelial Migration of Leukocytes	0.38

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for MMP9

	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

1 R&D Systems Pathway for MMP9

A-beta Uptake & Degradation

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP9 (see all 8)

	Glioma Invasiveness
	Inhibition of Angiogenesis by TSP1
	Inhibition of Matrix Metalloproteinases
	Relaxin Pathway
	Colorectal Cancer Metastasis

2 Cell Signaling Technology (CST) Pathways for MMP9

	Angiogenesis
	Protein Stability

3 GeneGo (Thomson Reuters) Pathways for MMP9

	Cell adhesion Cell-matrix glycoconjugates
	Development EGFR signaling pathway
	Cell adhesion ECM remodeling

5/18 BioSystems Pathways for MMP9 (see all 18)

	Angiogenesis
	Osteopontin Signaling
	Matrix Metalloproteinases
	AGE/RAGE pathway
	IL-3 Signaling Pathway

5/10 Reactome Pathways for MMP9 (see all 10)

	Assembly of collagen fibrils and other multimeric structures
	Collagen formation
	Degradation of collagen
	Activation of Matrix Metalloproteinases
	Extracellular matrix organization

1 PharmGKB Pathway for MMP9

Celecoxib Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for MMP9):

	Leukocyte transendothelial migration
	Pathways in cancer
	Bladder cancer

MMP9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for MMP9 (P14780^{1, 2, 3} ENSP00000361405⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AREG	P15514³, ENSP00000264487⁴	I2D: score=1 STRING: ENSP00000264487
IL8	P10145³, ENSP00000306512⁴	I2D: score=3 STRING: ENSP00000306512
LCN2	P80188³, ENSP00000277480⁴	I2D: score=3 STRING: ENSP00000277480
THBS2	P35442³, ENSP00000355751⁴	I2D: score=3 STRING: ENSP00000355751
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=2 STRING: ENSP00000225964

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0001503	ossification	--	--
GO:0001666	response to hypoxia	--	--
GO:0006508	proteolysis	IDA	2551898
GO:0006979	response to oxidative stress	--	--

MMP9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP9 for compounds About GeneDecksing

EMD Millipore small molecules for MMP9:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP9

Compounds for MMP9 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

3 HMDB Compounds for MMP9 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--
Zinc	Zinc (see all 2)	7440-66-6	--

10/140 Novoseek chemical compound relationships for MMP9 gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	86.9	112	9185711 (2), 12437074 (2), 15572024 (2), 18234959 (2) (see all 81)
vegf	78	926	16687082 (11), 17724228 (10), 16562680 (9), 12850503 (9) (see all 99)
(4-aminophenyl)mercuric acetate	76.8	9	7532211 (2), 11986939 (1), 8828413 (1), 15711750 (1) (see all 6)
batimastat	69.7	5	11448065 (1), 11276015 (1), 16689658 (1), 10951238 (1) (see all 5)
pck-3145	61.2	8	16550001 (4), 16283486 (3), 16197609 (1)
ilomastat	60.4	9	19545667 (2), 17512742 (1), 18782669 (1), 18414015 (1)
marimastat	60.1	13	12763661 (5), 16595036 (3), 17234180 (1), 9708737 (1)
cgs-27023a	57.6	2	19239231 (1), 15080939 (1)
col 3	51.8	8	12850461 (3), 16205320 (2), 11469893 (1), 17237909 (1) (see all 5)
doxycycline	51.8	87	15667660 (7), 19128246 (4), 10664501 (4), 19442784 (3) (see all 34)

Search CenterWatch for drugs/clinical trials and news about MMP9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP9 gene:

NM_004994.2

Unigene Cluster for MMP9:

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Hs.297413 [show with all ESTs]

Unigene Representative Sequence: NM_004994

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000372330(uc002xqz.3)

miRNA Products:		OriGene 3'-UTR Clone: MMP9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP9
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP9:
		hsa-miR-1224-3p hsa-miR-3713
		SwitchGear 3'UTR luciferase reporter plasmid: MMP9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP9 (see all 7) OriGene shRNA RFP: MMP9 OriGene siRNA: MMP9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP9
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP9 (NM_004994)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP9

Additional cDNA sequence:

AK298246.1 AK301446.1 AK302530.1 AK303080.1 AK311648.1 AK313137.1 AK316145.1 BC006093.1

HQ874462.1 J05070.1

20 DOTS entries:

DT.413883 DT.100024680 DT.95199801 DT.120817295 DT.120817587 DT.120817880 DT.120817870 DT.120817186

DT.120817482 DT.120817723 DT.120817759 DT.120817459 DT.97818783 DT.120817576 DT.100024681 DT.120817176

DT.92438252 DT.92438254 DT.91731953 DT.97790192

24/156 AceView cDNA sequences (see all 156):

BM707830 BC006093 BP337968 BE503223 AI968368 BI833565 BU626262 BI836570

BQ705891 BQ706480 R53437 F09820 BQ004583 BF432443 BF341249 AW293821

AI860333 BM921538 BQ184382 AI954665 CK902116 AI075104 AI652329 BU733323

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATCCCCA

About this image

MMP9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/51 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 51)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Cervical Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Lumbar Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Sacral Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Stylopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Thoracic Rib

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Thoracic Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Zeugopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See MMP9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP9

SOURCE GeneReport for Unigene cluster: Hs.297413

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Tissue specificity: Produced by normal alveolar macrophages and granulocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP9 (see all 26):

Lung Cancer in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP9 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP9¹	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) less	66.96(n) 62.54(a)		395387 NM_204667.1 NP_989998.1
African clawed frog (Xenopus laevis)	Amphibia	MGC69080²	hypothetical protein MGC69080	72.25(n)		BC057745.1
zebrafish (Danio rerio)	Actinopterygii	wufb02g06²	Danio rerio cDNA clone MGC64165 IMAGE6797338, complete cds less	70.96(n)		BC053292.1
worm (Caenorhabditis elegans)	Secernentea	H36L18.1⁶	Protein H36L18.1	20(a)	possible ortholog	X(12647047-12651417)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040¹	matrix metalloprotease domain-containing protein	52.76(n) 44.08(a)		819111 NM_130068.2 NP_182030.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	9(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 2(30974996-30977090)

ENSEMBL Gene Tree for MMP9 (if available)
TreeFam Gene Tree for MMP9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP9 gene

MMP13² MMP20² MMP8² MMP14² MMP16² MMP2² MMP25² MMP24²

MMP15² MMP11² MMP3² MMP27² MMP17² MMP10² MMP1²

1 SIMAP similar gene for MMP9 using alignment to 1 protein entry: MMP9_HUMAN:

MMP2

MMP9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121434556^1,2	C	pathogenic	44637567(+)	`CACCAA/TGAGCC`	2	K M	mis¹		0	--	--	--	--
rs3918257^1,2	C,F	--	41383318(+)	`CCGTGT/ACTCTT`	1	--	ds500¹		9		NS WA EU	1715
rs6017725^1,2	C	--	41383338(+)	`TCGCCC/TTGAAC`	1	--	ds500¹ ese³		1		NA	65
rs199821166^1,2	C,F	--	41383363(+)	`CCAACC/GACCAC`	1	--	ds500¹		1		EU	1323
rs201655080^1,2	C	--	41383466(+)	`CCCCCA/TCAGCT`	1	--	ds500¹		0	--	--	--	--
rs141884644^1,2	C,F	--	41383589(+)	`ACCAGC/TTGTAT`	1	--	nc-transcript-variant		1		NA	3674
rs201880215^1,2	C	--	41383633(+)	`TGGATA/GCGGGA`	1	--	nc-transcript-variant		0	--	--	--	--
rs3918258^1,2	C	--	41383639(+)	`CGGGAG/AGGGGC`	1	--	nc-transcript-variant		2		NS	94
rs185167031^1,2	C	--	41383705(+)	`GAGCCC/GGTCCT`	1	--	nc-transcript-variant		0	--	--	--	--
rs138685704^1,2	C,F	--	41383799(+)	`CAAGTG/AGCCCG`	1	--	nc-transcript-variant		1		NA	4282

HapMap Linkage Disequilibrium report for MMP9 (44637547 - 44645200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP9: --
Human Gene Mutation Database (HGMD): MMP9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP9

DNA2.0 Custom Variant and Variant Library Synthesis for MMP9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP9 for disorders           About GeneDecksing

OMIM gene information: 120361
OMIM disorders: 613073
UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Defects in MMP9 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]; also known

as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of

low-back pain and unilateral leg pain

Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal

anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with

the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are

evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs.

Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the

legs and rhizomelic micromelia

20/417 diseases for MMP9 (see all 417): About MalaCards

angle-closure glaucoma metaphyseal anadysplasia arthritis primary angle-closure glaucoma

metaphyseal anadysplasia 2 spinal cord injury internal hemorrhoid relapsing-remitting multiple sclerosis

hyper-ige syndrome pigmented villonodular synovitis toxic epidermal necrolysis encephalomyelitis

sorsby fundus dystrophy lentigo maligna melanoma open-angle glaucoma otitis media

hepatocellular carcinoma (fibrolamellar variant) stevens-johnson syndrome villonodular synovitis middle ear cholesteatoma

20/27 diseases from the University of Copenhagen DISEASES database for MMP9 (see all 27):

Carcinoma Atherosclerosis Heart disease Cerebrovascular accident

Abdominal aortic aneurysm Breast cancer Arthritis Lung cancer

Brain edema Chronic obstructive pulmonary disease Malignant glioma Periodontitis

Colorectal cancer Asthma Prostate cancer Hepatocellular carcinoma

Multiple sclerosis Hypertension Ovarian cancer Pancreatic cancer

10/96 Novoseek disease relationships for MMP9 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	81.9	868	9703281 (7), 12452001 (6), 12717827 (6), 11680936 (6) (see all 99)
tumors	78.3	1901	14584660 (7), 10053110 (7), 10831344 (6), 11078794 (6) (see all 99)
cancer	70	516	19141401 (5), 19360311 (5), 12600296 (4), 17034838 (3) (see all 99)
inflammation	69.7	254	15635615 (3), 19218638 (3), 18799677 (3), 10224466 (2) (see all 99)
atherosclerotic plaque	69.7	79	15585220 (5), 15772219 (4), 19581416 (3), 19575331 (3) (see all 43)
necrosis	65.3	334	8045973 (2), 9917505 (2), 11306564 (2), 18710428 (2) (see all 99)
aortic aneurysm abdominal	65.2	64	19525292 (2), 8691515 (2), 19119028 (2), 16779512 (2) (see all 37)
fibrosarcoma	63	63	15107580 (4), 11673527 (2), 10597035 (2), 17020790 (2) (see all 40)
atherosclerosis	58.8	84	17194891 (5), 18973519 (3), 19330590 (3), 12205736 (2) (see all 48)
carcinoma squamous cell	58	123	19541433 (4), 10053110 (4), 12218298 (4), 7850814 (3) (see all 77)

Genetic Association Database (GAD): MMP9
Human Genome Epidemiology (HuGE) Navigator: MMP9 (272 documents)

Export disorders for MMP9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP9 gene, integrated from 9 sources (see all 4203):
(articles sorted by number of sources associating them with MMP9)

Utopia: connect your pdf to the dynamic
world of online information

Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (PubMed id 15316122)^{1, 4, 9} Hulkkonen J....Lehtimaki T. (2004)
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (PubMed id 15823277)^{1, 4, 9} Pollanen P.J....Karhunen P.J. (2005)
Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma. (PubMed id 16026590)^{1, 4, 9} Ganter K....Heinzmann A. (2005)
Mutations in MMP9 and MMP13 determine the mode of inh eritance and the clinical spectrum of metaphyseal anadysplasia. (PubMed id 19615667)^{1, 2, 9} Lausch E....Zabel B. (2009)
Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis. (PubMed id 15691353)^{1, 4, 9} de Souza A.P....Line S.R. (2005)
A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer. (PubMed id 15565457)^{1, 4, 9} Matsumura S....Yasui W. (2005)
Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. (PubMed id 15748780)^{1, 4, 9} Shibata N....Arai H. (2005)
[Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2) and MMP-9 genes with risk of gastric cancer in a Chinese population.] (PubMed id 15522165)^{1, 4, 9} Zhang X.M....Lin D.X. (2004)
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. (PubMed id 1371271)^{1, 2, 9} Ogata Y.... Nagase H. (1992)
Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (PubMed id 16082623)^{1, 4, 9} Eriksson P....Powell J.T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4318	HGNC: 7176	AceView: MMP9	Ensembl:ENSG00000100985	euGenes: HUgn4318
ECgene: MMP9	Kegg: 4318	H-InvDB: MMP9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP9	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp9/
SeattleSNPs	http://pga.gs.washington.edu/data/mmp9/

Intellectual Property for MMP9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MMP9 gene:
Search GeneIP for patents involving MMP9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP9
	EMD Millipore Purified and/or Recombinant MMP9 Protein
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore small molecules (inhibitor) for MMP9
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for MMP9 (MMP-9)		Browse Cell Culture Products
	ELISAs for MMP9 (MMP-9)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Kinase Activity Assays/Reagents for MMP9 (MMP-9)
	ELISpot Kits/Development Modules for MMP9 (MMP-9)		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for MMP9 (MMP-9)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for MMP9 (MMP-9)

	OriGene Antibodies for MMP9		OriGene shRNA RFP for MMP9
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP9		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP9
	OriGene Protein Over-expression Lysate for MMP9		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MMP9		OriGene 3'-UTR Clone for MMP9
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP9
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MMP9		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MMP9		OriGene Custom Protein Services for MMP9
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP9
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP9
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP9
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP9

	GenScript Custom Purified and Recombinant Proteins Services for MMP9		GenScript cDNA clones with any tag delivered in your preferred vector for MMP9
	GenScript MMP9-Activity-based typehere Assay for Compound Screening		GenScript Custom Superior Antibodies Services for MMP9
	GenScript Custom overexpressing Cell Line Services for MMP9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for MMP9

	Regulatory tfbs in MMP9 promoter
	Search Chromatin IP Primers for MMP9
	RT² qPCR Primer Assay in human, mouse, rat MMP9
	GNC Network for MMP9
	SABiosciences PCR Arrays including human, mouse, rat MMP9

Tocris compounds for MMP9

	Proteins and Antibodies for MMP9
	cDNA Clones for MMP9
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Drugs/Proteins for MMP9
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MMP9 antibodies
	MMP9 proteins
	MMP9 lysates

	Antibodies for MMP9
	See all of Abcam's Antibodies, Kits and Proteins for MMP9
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for MMP9

MMP9 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MMP9

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP9

	SwitchGear 3'UTR luciferase reporter plasmids for MMP9
	SwitchGear Promoter luciferase reporter plasmids for MMP9

ThermoFisher Antibody for MMP9

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MMP9

Sirion Biotech Customized:

	stable knockdown cell line services for MMP9
	inducible knockdown cell line services for MMP9
	design and validation of potent shRNA sequences against MMP9
	adenovirus for potent knockdown of MMP9
	adenovirus for overexpression of MMP9
	stable overexpressing cell line services for MMP9
	inducible overexpressing cell line services for MMP9

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MMP9 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MMP9 Gene

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase,...

Aliases
for MMP9 gene

Summaries
for MMP9 gene

Genomic Views
for MMP9 gene

Proteins
for MMP9 gene

Protein Domains /
Families
for MMP9 gene

Function
for MMP9 gene

Pathways & Interactions
for MMP9 gene

Drugs & Compounds
for MMP9 gene

Transcripts
for MMP9 gene

Expression
for MMP9 gene

Orthologs
for MMP9 gene

Paralogs
for MMP9 gene

Genomic Variants
for MMP9 gene

Disorders / Diseases
for MMP9 gene

Publications
for MMP9 gene

External Searches for MMP9 gene

Genome Databases showing MMP9 gene

Other Databases showing MMP9 gene

Specialized Databases showing MMP9 gene

Intellectual Property
for MMP9 gene

Products
for MMP9 gene

View Random Gene

Pulmonary Emphysema
TONGUE CARCINOMA
Acute myocardial infarction
aggressiveness
COLON CARCINOMA
ADENOCARCINOMA LUNG
Paraparesis Tropical Spastic
Anaplastic Astrocytoma
lung metastases
LUNG CARCINOMA
Keratoconjunctivitis Vernal
Lymphatic Metastasis
Atherosclerosis
Breast Cancer
Neovascularization
NSCLC
primary tumor
Adenocarcinoma
Asthma
Carcinoma Transitional Cell
Cancer
Aneurysm
Colorectal Carcinoma
Carcinoma Lewis Lung
Coronary Atherosclerosis
Periodontal Diseases
Pathological Processes
GASTRIC CARCINOMA
Ovarian Cancer
Bronchoalveolar Lavage Fluid
Nasal Polyps
Colorectal Cancer
Multiple Sclerosis
HNSCC
Inflammation
osteolytic
Oral Cancer
Pulmonary Disease Chronic Obstructive
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
prostate cancer
Tumors
Metastasis
Kawasaki Disease
Multiple Sclerosis Relapsing-Remitting
Fibrosarcoma
Necrosis
Glioblastoma
HEALING DELAYED
Carotid Atherosclerosis
Malignant Glioma
FIBROSIS IDIOPATHIC PULMONARY
Gastric Cancer
BREAST CARCINOMA
Melanoma
bladder cancer
Colon Cancer
OVARIAN TUMOR BENIGN
Pulmonary Fibrosis
Carotid Stenosis
Glioma
atherosclerotic plaque
Liver Fibrosis
BONE TUMOR
Cholesteatoma
Carcinoma
Astrocytoma
Osteoarthritis
cancer invasiveness
epithelial tumor
PROSTATE CARCINOMA
Conjunctivochalasis
Osteosarcoma
metastatic cancer
HEPATOCELLULAR CARCINOMA
Carcinoma Renal Cell
Pancreatic Cancer
Cancer Lung
Ischemic Brain Injury
Coronary Artery Disease
anaplastic meningioma
Aortic Aneurysm Abdominal
Proliferative diabetic retinopathy
Breakthrough Bleeding
Chronic periodontitis
OVARIAN CARCINOMA
Giant Cell Tumors
solid tumor
Carcinoma Squamous Cell
Lung diseases
Cerebral Ischemia
Vascular Diseases
Cholesteatoma Middle Ear
stromal tumors
BONE DESTRUCTION
Arthritis

Advanced Search

Export list of displayed genes

MMP9 Gene

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase,...

Aliasesfor MMP9 gene

Summariesfor MMP9 gene

Genomic Viewsfor MMP9 gene

Proteinsfor MMP9 gene

Protein Domains /Familiesfor MMP9 gene

Functionfor MMP9 gene

Pathways & Interactionsfor MMP9 gene

Drugs & Compoundsfor MMP9 gene

Transcriptsfor MMP9 gene

Expression for MMP9 gene

Orthologsfor MMP9 gene

Paralogsfor MMP9 gene

Genomic Variantsfor MMP9 gene

Disorders / Diseasesfor MMP9 gene

Publicationsfor MMP9 gene

External Searches for MMP9 gene

Genome Databases showing MMP9 gene

Other Databases showing MMP9 gene

Specialized Databases showing MMP9 gene

Intellectual Propertyfor MMP9 gene

Productsfor MMP9 gene

View Random Gene

Aliases
for MMP9 gene

Summaries
for MMP9 gene

Genomic Views
for MMP9 gene

Proteins
for MMP9 gene

Protein Domains /
Families
for MMP9 gene

Function
for MMP9 gene

Pathways & Interactions
for MMP9 gene

Drugs & Compounds
for MMP9 gene

Transcripts
for MMP9 gene

Expression
for MMP9 gene

Orthologs
for MMP9 gene

Paralogs
for MMP9 gene

Genomic Variants
for MMP9 gene

Disorders / Diseases
for MMP9 gene

Publications
for MMP9 gene

Intellectual Property
for MMP9 gene

Products
for MMP9 gene