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Aliases for MMP9 Gene

Aliases for MMP9 Gene

  • Matrix Metallopeptidase 9 2 3
  • CLG4B 3 4 6
  • Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 2 3
  • EC 4 63
  • MANDP2 3 6
  • MMP-9 3 4
  • GELB 3 4
  • Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 3
  • Matrix Metalloproteinase-9 3
  • 92 KDa Type IV Collagenase 4
  • Macrophage Gelatinase 3
  • Type V Collagenase 3
  • 92 KDa Gelatinase 4
  • Gelatinase B 4
  • EC 3.4.24 63

External Ids for MMP9 Gene

Previous HGNC Symbols for MMP9 Gene

  • CLG4B

Previous GeneCards Identifiers for MMP9 Gene

  • GC20P044366
  • GC20P045275
  • GC20P045322
  • GC20P044070
  • GC20P044637
  • GC20P041378

Summaries for MMP9 Gene

Entrez Gene Summary for MMP9 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP9 Gene

MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include metaphyseal anadysplasia 2 and metaphyseal anadysplasia. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include identical protein binding and collagen binding. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP9 Gene

  • May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Tocris Summary for MMP9 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP9 Gene

Genomics for MMP9 Gene

Regulatory Elements for MMP9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP9 Gene

46,008,908 bp from pter
46,016,561 bp from pter
7,654 bases
Plus strand

Genomic View for MMP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP9 Gene

Proteins for MMP9 Gene

  • Protein details for MMP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix metalloproteinase-9
    Protein Accession:
    Secondary Accessions:
    • B2R7V9
    • Q3LR70
    • Q8N725
    • Q9H4Z1
    • Q9UCJ9
    • Q9UCL1
    • Q9UDK2

    Protein attributes for MMP9 Gene

    707 amino acids
    Molecular mass:
    78458 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
    • In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status

    Three dimensional structures from OCA and Proteopedia for MMP9 Gene

neXtProt entry for MMP9 Gene

Proteomics data for MMP9 Gene at MOPED

Post-translational modifications for MMP9 Gene

  • N- and O-glycosylated.
  • Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  • Glycosylation at Asn38, Asn120, and Asn127
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP9 (MMP9)

Domains for MMP9 Gene

Suggested Antigen Peptide Sequences for MMP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P14780
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 3 fibronectin type-II domains.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP9: view

Function for MMP9 Gene

Molecular function for MMP9 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of gelatin types I and V and collagen types IV and V.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
UniProtKB/Swiss-Prot Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
UniProtKB/Swiss-Prot Induction:
Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.

Enzyme Numbers (IUBMB) for MMP9 Gene

Gene Ontology (GO) - Molecular Function for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 19022250
GO:0004222 metalloendopeptidase activity IDA 16192646
GO:0005515 protein binding IPI 16512877
GO:0005518 collagen binding TAS 2251898
GO:0008233 peptidase activity --
genes like me logo Genes that share ontologies with MMP9: view
genes like me logo Genes that share phenotypes with MMP9: view

Animal Models for MMP9 Gene

MGI Knock Outs for MMP9:

Animal Model Products

miRNA for MMP9 Gene

miRTarBase miRNAs that target MMP9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP9

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MMP9 Gene

Localization for MMP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP9 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for MMP9 Gene COMPARTMENTS Subcellular localization image for MMP9 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2
mitochondrion 2
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 2251898
GO:0031012 extracellular matrix --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MMP9: view

Pathways for MMP9 Gene

genes like me logo Genes that share pathways with MMP9: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006508 proteolysis IDA 15863497
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with MMP9: view

Compounds for MMP9 Gene

Compound Products

(5) Tocris Compounds for MMP9 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(4) ApexBio Compounds for MMP9 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor [130370-60-4]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Marimastat "MMPs inhibitor,board spectrum" [154039-60-8]
SB-3CT [292605-14-2]

(3) HMDB Compounds for MMP9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • (+)-Simvastatin
  • Zinc

(140) Novoseek inferred chemical compound relationships for MMP9 Gene

Compound -log(P) Hits PubMed IDs
matrigel 86.9 89
vegf 78 429
(4-aminophenyl)mercuric acetate 76.8 7
batimastat 69.7 5
pck-3145 61.2 8
genes like me logo Genes that share compounds with MMP9: view

Transcripts for MMP9 Gene

mRNA/cDNA for MMP9 Gene

(156) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP9 Gene

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP9 Gene

No ASD Table

Relevant External Links for MMP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP9 Gene

mRNA expression in normal human tissues for MMP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP9 Gene

This gene is overexpressed in Whole Blood (46.3).

Protein differential expression in normal tissues for MMP9 Gene

This gene is overexpressed in Neutrophil (45.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP9 Gene

SOURCE GeneReport for Unigene cluster for MMP9 Gene Hs.297413

mRNA Expression by UniProt/SwissProt for MMP9 Gene

Tissue specificity: Produced by normal alveolar macrophages and granulocytes
genes like me logo Genes that share expressions with MMP9: view

Expression partners for MMP9 Gene

In Situ Assay Products

Orthologs for MMP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MMP9 35
  • 83.55 (n)
  • 79.49 (a)
MMP9 36
  • 80 (a)
(Canis familiaris)
Mammalia MMP9 35
  • 84.37 (n)
  • 79.83 (a)
MMP-9 36
  • 81 (a)
(Mus musculus)
Mammalia Mmp9 35
  • 78.36 (n)
  • 74.72 (a)
Mmp9 16
Mmp9 36
  • 72 (a)
(Pan troglodytes)
Mammalia MMP9 35
  • 99.57 (n)
  • 99.43 (a)
MMP9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mmp9 35
  • 78.77 (n)
  • 74.47 (a)
(Monodelphis domestica)
Mammalia MMP9 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
-- 36
  • 51 (a)
(Gallus gallus)
Aves MMP9 35
  • 67.32 (n)
  • 63.14 (a)
MMP9 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494738 35
  • 60.26 (n)
  • 59.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69080 35
(Danio rerio)
Actinopterygii mmp9 35
  • 60.77 (n)
  • 60.31 (a)
wufb02g06 35
mmp9 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10476 35
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 22 (a)
zmp-1 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45040 35
  • 46.18 (n)
  • 35.32 (a)
Species with no ortholog for MMP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP9 Gene

Gene Tree for MMP9 (if available)
Gene Tree for MMP9 (if available)

Paralogs for MMP9 Gene

Paralogs for MMP9 Gene

Selected SIMAP similar genes for MMP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP9: view

Variants for MMP9 Gene

Sequence variations from dbSNP and Humsavar for MMP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9509 -- 46,016,514(+) ACCTT(C/T)GTTTT utr-variant-3-prime
rs13925 -- 46,016,326(+) CAAGT(A/G)GGCTA synonymous-codon, reference
rs13969 -- 46,014,194(+) CTGGG(A/C)GCCGA reference, synonymous-codon
rs17576 - 46,011,586(+) CACCC(A/G)GGACG reference, missense
rs17577 - 46,014,472(+) GTACC(A/C/G)AGGTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MMP9 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV Loss 17160897

Relevant External Links for MMP9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP9 Gene

Disorders for MMP9 Gene

(1) OMIM Diseases for MMP9 Gene (120361)


  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Note=The disease is caused by mutations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for MMP9 Gene

Disease -log(P) Hits PubMed IDs
metastasis 81.9 285
tumors 78.3 376
cancer 70 173
inflammation 69.7 127
atherosclerotic plaque 69.7 61

Relevant External Links for MMP9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MMP9: view

No data available for Genatlas for MMP9 Gene

Publications for MMP9 Gene

  1. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. (PMID: 1400481) Okada Y. … Hayakawa T. (J. Biol. Chem. 1992) 3 4 23
  2. Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis. (PMID: 11410119) Wang J. … Wang X.L. (Clin. Sci. 2001) 3 23 48
  3. Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study. (PMID: 11557670) PAPllAonen P.J. … LehtimAoki T. (Arterioscler. Thromb. Vasc. Biol. 2001) 3 23 48
  4. Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. (PMID: 11708786) Minematsu N. … Yamaguchi K. (Biochem. Biophys. Res. Commun. 2001) 3 23 48
  5. Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention. (PMID: 11916008) Cho H.J. … Park Y.B. (J. Hum. Genet. 2002) 3 23 48

Products for MMP9 Gene

Sources for MMP9 Gene

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