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MMP9 Gene

protein-coding   GIFtS: 74
GCID: GC20P044637

Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase,...

(Previous names: matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase,...)
(Previous symbol: CLG4B)
  See MMP9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type
IV Collagenase)1 2
     MANDP22 5
CLG4B1 2 3 5     Matrix Metalloproteinase 9 (Gelatinase B, 92kD Gelatinase, 92kD Type IV
Collagenase)1
Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV
Collagenase)1 2
     Macrophage Gelatinase2
92 KDa Gelatinase2 3     Matrix Metalloproteinase-92
92 KDa Type IV Collagenase2 3     Type V Collagenase2
GELB2 3     Gelatinase B3
MMP-92 3     EC 3.4.248
EC 3.4.24.353 8     

External Ids:    HGNC: 71761   Entrez Gene: 43182   Ensembl: ENSG000001009857   OMIM: 1203615   UniProtKB: P147803   

Export aliases for MMP9 gene to outside databases

Previous GC identifers: GC20P044366 GC20P045275 GC20P045322 GC20P044070 GC20P041378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP9 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V
collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of
hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue
remodeling. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP9 Gene:
MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)) is a protein-coding gene. Diseases associated with MMP9 include adamantinous craniopharyngioma, and middle ear squamous cell carcinoma. GO annotations related to this gene include collagen binding and identical protein binding. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780
Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.
Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V
collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades
fibronectin but not laminin or Pz-peptide

summary for MMP9 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP9 gene promoter:
         Max   USF1   USF-1   NRSF form 1   USF2   USF-1:USF-2   NRSF form 2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP9 promoter sequence
   Search Chromatin IP Primers for MMP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2-q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13

MMP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP9 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044637:  view genomic region     (about GC identifiers)

Start:
44,637,547 bp from pter      End:
44,645,200 bp from pter
Size:
7,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780 (See protein sequence)
Recommended Name: Matrix metalloproteinase-9 precursor  
Size: 707 amino acids; 78458 Da
Cofactor: Binds 2 zinc ions per subunit
Cofactor: Binds 3 calcium ions per subunit
Subunit: Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein.
Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1
Miscellaneous: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and
might constitute a useful marker of disease status
Selected PDB 3D structures from and Proteopedia for MMP9 (see all 15):
1GKC (3D)        1GKD (3D)        1ITV (3D)        1L6J (3D)        1LKG (3D)        2OVX (3D)    
Secondary accessions: B2R7V9 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1 Q9UDK2

Explore the universe of human proteins at neXtProt for MMP9: NX_P14780

Explore proteomics data for MMP9 at MOPED

Post-translational modifications: 

  • Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3
    yields the 82 kDa matrix metalloproteinase-91
  • N- and O-glycosylated1
  • Glycosylation2 at Asn38, Asn120, Asn127
  • Selected DME Specific Peptides for MMP9 (P14780) (see all 13)
     FFFSGRQ  GLLAHAF  IGNQLYL  DGYPFDG 


    See MMP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004985.2  
    ENSEMBL proteins: 
     ENSP00000361405  
    Reactome Protein details: P14780

    MMP9 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MMP9 Protein
    R&D Systems Recombinant & Natural Proteins for MMP9 (MMP-9)
    Enzo Life Sciences proteins for MMP9
    OriGene Purified Protein for MMP9
    OriGene Protein Over-expression Lysate for MMP9
    OriGene MassSpec for MMP9
    OriGene Custom Protein Services for MMP9
    GenScript Custom Purified and Recombinant Proteins Services for MMP9
    Novus Biologicals MMP9 Proteins
    Novus Biologicals MMP9 Lysate
    Sino Biological Recombinant Protein for MMP9
    Sino Biological Cell Lysate for MMP9
    ProSpec Recombinant Protein for MMP9
    Cloud-Clone Corp. Proteins for MMP9

     
    Search eBioscience for Proteins for MMP9 

     
    antibodies-online proteins for MMP9 (57 products) 

     
    antibodies-online peptides for MMP9

    MMP9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP9
    R&D Systems Antibodies for MMP9 (MMP-9)
    Cell Signaling Technology (CST) Antibodies for MMP9 
    OriGene Antibodies for MMP9
    OriGene Custom Antibody Services for MMP9
    Novus Biologicals MMP9 Antibodies
    Abcam antibodies for MMP9
    Cloud-Clone Corp. Antibodies for MMP9
    ThermoFisher Antibody for MMP9
    antibodies-online antibodies for MMP9 (321 products) 

    MMP9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP9
    R&D Systems ELISAs for MMP9 (MMP-9)         (see first)
    R&D Systems ELISpot/FluoroSpot Kits & Development Modules for MMP9 (MMP-9)
    R&D Systems Luminex Assays for MMP9 (MMP-9)
    R&D Systems Enzyme Activity Assays & Reagents for MMP9 (MMP-9)
    R&D Systems Proteome Profiler Antibody Arrays for MMP9 (MMP-9)
    See all other biochemical assays at R&D Systems
    GenScript MMP9-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP9
    Cloud-Clone Corp. ELISAs for MMP9
    Cloud-Clone Corp. CLIAs for MMP9
    eBioscience ELISAs for MMP9: (see all 2
                        Human MMP-9 Platinum ELISA 96 tests
    antibodies-online kits for MMP9 (68 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP9
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 13):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P14780

    ProtoNet protein and cluster: P14780

    4 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 3 fibronectin type-II domains
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP9_HUMAN, P14780
    Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.
    Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V
    collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades
    fibronectin but not laminin or Pz-peptide
    Catalytic activity: Cleavage of gelatin types I and V and collagen types IV and V
    Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1
    Induction: Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC
    via the JNK signaling pathway in colorectal tumor cells

         Genatlas biochemistry entry for MMP9:
    matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast
    cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and
    apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the
    migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of
    myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in
    diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the
    remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis

         Enzyme Numbers (IUBMB): EC 3.4.24.351 2 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IDA16192646
    GO:0005515protein binding IPI16512877
    GO:0005518collagen binding TAS2251898
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity ----
         
    Find genes that share ontologies with MMP9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MMP9:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mmp9) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  renal/urinary system  reproductive system 

    Find genes that share phenotypes with MMP9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MMP9: Mmp9tm1Itoh Mmp9tm1Tvu Mmp9tm1Arnd Mmp9tm1Amr

       genOway: Develop your customized and physiologically relevant rodent model for MMP9

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP9:
    hsa-mir-338-3p (MIRT019229), hsa-mir-451a (MIRT005743), hsa-mir-21-5p (MIRT030871)

    Block miRNA regulation of human, mouse, rat MMP9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MMP9:
    hsa-miR-1224-3p hsa-miR-3713
    SwitchGear 3'UTR luciferase reporter plasmidMMP9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP9
    Predesigned siRNA for gene silencing in human, mouse, rat MMP9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP9

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP9 (see all 6)
    OriGene ORF clones in mouse, rat for MMP9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP9 (NM_004994)
    Sino Biological Human cDNA Clone for MMP9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP9

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP9
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP9

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11109) for MMP9 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP9_HUMAN, P14780: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytoskeleton2
    cytosol2
    mitochondrion2
    golgi apparatus1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA2251898
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MMP9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP9 About   (see all 44)  
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    Inhibition of Angiogenesis by TSP10.50
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Assembly of collagen fibrils and other multimeric structures0.62


    Find genes that share SuperPaths with MMP9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for MMP9
        A-beta Uptake & Degradation
    A-beta Plaque Formation & APP Metabolism

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP9 (see all 8)
        Glioma Invasiveness
    Inhibition of Angiogenesis by TSP1
    Inhibition of Matrix Metalloproteinases
    Relaxin Pathway
    Colorectal Cancer Metastasis

    2 Cell Signaling Technology (CST) Pathways for MMP9
        Angiogenesis
    Protein Stability

    3 GeneGo (Thomson Reuters) Pathways for MMP9
        Cell adhesion Cell-matrix glycoconjugates
    Development EGFR signaling pathway
    Cell adhesion ECM remodeling

    Selected BioSystems Pathways for MMP9 (see all 19)
        Osteopontin Signaling
    Angiogenesis
    Matrix Metalloproteinases
    AGE/RAGE pathway
    Spinal Cord Injury


    5 Reactome Pathways for MMP9
        Assembly of collagen fibrils and other multimeric structures
    Signaling by SCF-KIT
    Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases

    1 PharmGKB Pathway for MMP9
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MMP9) (see all 9):
        TNF signaling pathway
    Leukocyte transendothelial migration
    Estrogen signaling pathway
    Hepatitis B
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP9 (see all 26): 
              Lung Cancer in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MMP9 (P147801, 2, 3 ENSP000003614054) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCANP136111, 2EBI-1382326,EBI-8515977 MINT-8427495 MINT-8427508 MINT-8427443
    MEP1AQ168191, 2EBI-1382326,EBI-8153734 MINT-8399907 MINT-8399930
    MEP1BQ168201, 2EBI-1382326,EBI-968418 MINT-8399917 MINT-8399942
    ENSG00000184494Q995193I2D: score=1 
    ENSG00000223957Q995193I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001503ossification IEA--
    GO:0006508proteolysis IDA2551898
    GO:0007566embryo implantation IEA--
    GO:0022617extracellular matrix disassembly TAS--

    Find genes that share ontologies with MMP9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP9
    Selected ApexBio Compounds for MMP9 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    3 HMDB Compounds for MMP9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--
    ZincZinc (see all 2)7440-66-6--

    Selected Novoseek inferred chemical compound relationships for MMP9 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 86.9 112 9185711 (2), 12437074 (2), 15572024 (2), 18234959 (2) (see all 81)
    vegf 78 926 16687082 (11), 17724228 (10), 16562680 (9), 12850503 (9) (see all 99)
    (4-aminophenyl)mercuric acetate 76.8 9 7532211 (2), 11986939 (1), 8828413 (1), 15711750 (1) (see all 6)
    batimastat 69.7 5 11448065 (1), 11276015 (1), 16689658 (1), 10951238 (1) (see all 5)
    pck-3145 61.2 8 16550001 (4), 16283486 (3), 16197609 (1)
    ilomastat 60.4 9 19545667 (2), 17512742 (1), 18782669 (1), 18414015 (1)
    marimastat 60.1 13 12763661 (5), 16595036 (3), 17234180 (1), 9708737 (1)
    cgs-27023a 57.6 2 19239231 (1), 15080939 (1)
    col 3 51.8 8 12850461 (3), 16205320 (2), 11469893 (1), 17237909 (1) (see all 5)
    doxycycline 51.8 87 15667660 (7), 19128246 (4), 10664501 (4), 19442784 (3) (see all 34)



    Find genes that share compounds with MMP9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP9 gene: 
    NM_004994.2  

    Unigene Cluster for MMP9:

    Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    Hs.297413  [show with all ESTs]
    Unigene Representative Sequence: NM_004994
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372330(uc002xqz.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MMP9:
    hsa-miR-1224-3p hsa-miR-3713
    SwitchGear 3'UTR luciferase reporter plasmidMMP9 3' UTR sequence
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    eBioscience FlowRNA Probe Sets ( VA1-11109) for MMP9 

    Additional mRNA sequence: 

    AK298246.1 AK301446.1 AK302530.1 AK303080.1 AK311648.1 AK313137.1 AK316145.1 BC006093.1 
    HQ874462.1 J05070.1 

    20 DOTS entries:

    DT.413883  DT.100024680  DT.95199801  DT.120817295  DT.120817587  DT.120817880  DT.120817870  DT.120817186 
    DT.120817482  DT.120817723  DT.120817759  DT.120817459  DT.97818783  DT.120817576  DT.100024681  DT.120817176 
    DT.92438252  DT.92438254  DT.91731953  DT.97790192 

    Selected AceView cDNA sequences (see all 156):

    AI968368 F09820 R53437 BM707830 BQ705891 BC006093 BI833565 BU626262 
    BE503223 BI836570 BQ706480 BQ004583 BP337968 BQ582132 BF341249 BM989019 
    BQ183679 BI029217 AW608168 BM921538 CK902116 BU733323 NM_004994 BF339705 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCCCCA
    MMP9 Expression
    About this image


    MMP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 11 entries
             Hypertrophic Chondrocytes Rib
             Bone Marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Hypertrophic Chondrocytes Rib
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 10 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
    MMP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.297413

    UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780
    Tissue specificity: Produced by normal alveolar macrophages and granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP9 (see all 26): 
              Lung Cancer in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp91 , 5 matrix metallopeptidase 91, 5 78.36(n)1
    74.72(a)1
      2 (85.27 cM)5
    173951  NM_013599.31  NP_038627.11 
     1649407805 
    chicken
    (Gallus gallus)
    Aves MMP91 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) less 67.32(n)
    63.14(a)
      395387  NM_204667.1  NP_989998.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    many ↔ many
    AAWZ02037835(390-2516)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690802 hypothetical protein MGC69080 72.25(n)    BC057745.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb02g062 Danio rerio cDNA clone MGC64165 IMAGE6797338, complete cds less 70.96(n)    BC053292.1 
    worm
    (Caenorhabditis elegans)
    Secernentea H19M22.36
    zmp-16
    Protein ZMP-1 (zmp-1) mRNA, complete cds
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    III(2636405-2642848) WBGene00019212
    III(5926898-5932953) WBGene00006987
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G450401 AT2G45040 46.18(n)
    35.32(a)
      819111  NM_130068.2  NP_182030.1 


    ENSEMBL Gene Tree for MMP9 (if available)
    TreeFam Gene Tree for MMP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP9 gene
    MMP212  MMP23B2  MMP22  MMP192  MMP262  ELSPBP12  
    1 SIMAP similar gene for MMP9 using alignment to 1 protein entry:     MMP9_HUMAN:
    MMP2

    Find genes that share paralogs with MMP9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP9 (see all 320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214345561,2
    Cpathogenic144608084(+) CACCAA/TGAGCC 2 K M mis10--------
    rs1413234981,2
    --44606107(+) TATTAC/TTATGG 1 -- us2k10--------
    rs1450513401,2
    --44606120(+) CAGAGA/GTAAAG 1 -- us2k10--------
    rs39182401,2
    C,F,A,H--44606133(+) ACTTGC/TCCAAG 1 -- us2k119Minor allele frequency- T:0.47NS NA WA CSA EA 630
    rs39182781,2
    C,F,H--44606171(+) GGGATG/AGAAAT 1 -- us2k123Minor allele frequency- A:0.02NS EA NA 2082
    rs39182411,2
    C,F,A,H--44606252(+) GGAAGT/ATAATT 1 -- us2k1 tfbs326Minor allele frequency- A:0.15NS EA NA WA 2042
    rs1889506421,2
    --44606326(+) TTTAAA/TTACAG 1 -- us2k10--------
    rs1468496701,2
    --44606339(+) TATTGG/TGCCGG 1 -- us2k10--------
    rs1406376781,2
    C--44606342(+) TGGGCC/TGGGCG 1 -- us2k10--------
    rs454427921,2
    C,F--44606347(+) CGGGCG/ACCATG 1 -- us2k15Minor allele frequency- A:0.01NS 186

    HapMap Linkage Disequilibrium report for MMP9 (44637547 - 44645200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833991CNV Loss17160897

    Human Gene Mutation Database (HGMD): MMP9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP9
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120361   
    OMIM disorders: 613073  
    UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration
    of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal
    anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life
    and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature
    in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic
    micromelia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for MMP9 (see all 67):    
    About MalaCards
    adamantinous craniopharyngioma    middle ear squamous cell carcinoma    hemorrhoid    internal hemorrhoid
    metaphyseal anadysplasia 2    central nervous system tuberculosis    spondyloepimetaphyseal dysplasia, missouri type    metaphyseal anadysplasia
    nasal cavity squamous cell carcinoma    lymphocytic colitis    anal fistula    sick building syndrome
    gingival hypertrophy    klatskin's tumor    hydrolethalus syndrome 1    blepharitis
    focal myositis    carotid stenosis    arthritis    diverticulitis

    Selected diseases from the University of Copenhagen DISEASES database for MMP9 (see all 28):
    Carcinoma     Atherosclerosis     Heart disease     Cerebrovascular accident
    Abdominal aortic aneurysm     Breast cancer     Arthritis     Lung cancer
    Chronic obstructive pulmonary disease     Brain edema     Periodontitis     Malignant glioma
    Asthma     Colorectal cancer     Prostate cancer     Multiple sclerosis
    Hepatocellular carcinoma     Hypertension     Ovarian cancer     Keratitis

    Find genes that share disorders with MMP9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MMP9 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 81.9 868 9703281 (7), 12452001 (6), 12717827 (6), 11680936 (6) (see all 99)
    tumors 78.3 1901 14584660 (7), 10053110 (7), 10831344 (6), 11078794 (6) (see all 99)
    cancer 70 516 19141401 (5), 19360311 (5), 12600296 (4), 17034838 (3) (see all 99)
    inflammation 69.7 254 15635615 (3), 19218638 (3), 18799677 (3), 10224466 (2) (see all 99)
    atherosclerotic plaque 69.7 79 15585220 (5), 15772219 (4), 19581416 (3), 19575331 (3) (see all 43)
    necrosis 65.3 334 8045973 (2), 9917505 (2), 11306564 (2), 18710428 (2) (see all 99)
    aortic aneurysm abdominal 65.2 64 19525292 (2), 8691515 (2), 19119028 (2), 16779512 (2) (see all 37)
    fibrosarcoma 63 63 15107580 (4), 11673527 (2), 10597035 (2), 17020790 (2) (see all 40)
    atherosclerosis 58.8 84 17194891 (5), 18973519 (3), 19330590 (3), 12205736 (2) (see all 48)
    carcinoma squamous cell 58 123 19541433 (4), 10053110 (4), 12218298 (4), 7850814 (3) (see all 77)

    Genetic Association Database (GAD): MMP9
    Human Genome Epidemiology (HuGE) Navigator: MMP9 (272 documents)

    Export disorders for MMP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP9 gene, integrated from 10 sources (see all 4414):
    (articles sorted by number of sources associating them with MMP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PubMed id 18455130)1, 2, 4 Hirose Y....Ikegawa S. (Am. J. Hum. Genet. 2008)
    2. Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (PubMed id 15316122)1, 4, 9 Hulkkonen J....LehtimAoki T. (Rheumatology (Oxford) 2004)
    3. Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population. (PubMed id 20110530)1, 4, 9 Wipff J....Allanore Y. (J. Rheumatol. 2010)
    4. Haplotype analysis of the stromelysin-1 (MMP3) and gelatinase B (MMP9) genes in relation to coronary heart disease. (PubMed id 19438845)1, 4, 9 Wu N....Yang Y. (Ann. Hum. Genet. 2009)
    5. MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (PubMed id 17448043)1, 4, 9 Chen D....Wu Z.F. (J. Clin. Periodontol. 2007)
    6. Matrix metalloproteinase-1 and -9 promoter polymorphisms are not associated with an increased risk of uterine leiomyomas in a Japanese population. (PubMed id 16638593)1, 4, 9 Takemura N....Maruo T. (J. Soc. Gynecol. Investig. 2006)
    7. Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (PubMed id 15823277)1, 4, 9 PAPllAonen P.J....Karhunen P.J. (Atherosclerosis 2005)
    8. Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma. (PubMed id 16026590)1, 4, 9 Ganter K....Heinzmann A. (Int. J. Immunogenet. 2005)
    9. Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. (PubMed id 20184534)1, 4, 9 Wu S....Ko Y.L. (Clin. Chem. Lab. Med. 2010)
    10. Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer. (PubMed id 19906411)1, 4, 9 Brooks R....Rader J.S. (Gynecol. Oncol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4318 HGNC: 7176 AceView: MMP9 Ensembl:ENSG00000100985 euGenes: HUgn4318
    ECgene: MMP9 Kegg: 4318 H-InvDB: MMP9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MMP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp9/
    SeattleSNPshttp://pga.gs.washington.edu/data/mmp9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP9 gene:
    Search GeneIP for patents involving MMP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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