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MMP9 Gene

protein-coding GIFtS: 71

GC20P044070

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
(Previous names: matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CLG4B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CLG4B ^², ³, ⁵
EC 3.4.24.35 ^³
GELB ^², ³
MMP-9 ^², ³
OTTHUMP00000031674 ^²

Descriptions
92 kDa gelatinase ^³
92 kDa type IV collagenase ^³
Gelatinase B ^³
macrophage gelatinase ^²
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) ^²
matrix metalloproteinase 9 ^²
matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase) ^¹
matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) ^¹, ²
type V collagenase ^²

External Ids
HGNC: 7176¹
Entrez Gene: 4318²
UniProtKB: P14780³
Ensembl: ENSG00000100985⁷

Search outside databases for aliases for MMP9 gene

Previous GC identifers: GC20P044366 GC20P045275 GC20P045322

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MMP9:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of

extracellular matrix in normal physiological processes, such as embryonic development,

reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and

metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved

by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens.

Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of

hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in

tumor-associated tissue remodeling. [provided by RefSeq]

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Function: May play an essential role in local proteolysis of the extracellular matrix and in

leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-

-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and

shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide

Gene Wiki entry for MMP9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MMP9 gene

Entrez Gene cytogenetic band: 20q11.2-q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12-q13

MMP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P044070: (about GC identifiers)

Start:	44,070,954 bp from pter
End:	44,078,607 bp from pter
Size:	7,654 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780 (See protein sequence)

Recommended Name: Matrix metalloproteinase-9 precursor

Size: 707 amino acids; 78399 Da

Cofactor: Binds 2 zinc ions per subunit

Cofactor: Binds 3 calcium ions per subunit

Subunit: Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein.

Macrophages and transformed cell lines produce only the monomeric form

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

Miscellaneous: In the arthritis patient this enzyme might contribute to the pathogenesis of joint

destruction and might constitute a useful marker of disease status

PDB structures from and Proteopedia :

1GKC (3D)

1GKD (3D)

1ITV (3D)

1L6J (3D)

1LKG (3D)

2OVX (3D)

2OVZ (3D)

2OW0 (3D)

2OW1 (3D)

2OW2 (3D)

Secondary accessions: B2R7V9 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1

Post-translational modifications:

Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially

processing by MMP3 yields the 82 kDa matrix metalloproteinase-9¹

N- and O-glycosylated¹

REFSEQ proteins: NP_004985.2

ENSEMBL proteins:

ENSP00000361405

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MMP9 Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for MMP9
	R&D Systems Recombinant & Natural Proteins for MMP9 (MMP-9)
	Enzo Life Sciences proteins for MMP9
	Recombinant Proteins from Abcam (MMP9)
	Human Recombinant Proteins from Abnova (MMP9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	2251898

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Antibodies for MMP9:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MMP9
	Sigma-Aldrich Antibodies for MMP9
	R&D Systems Antibodies for MMP9 (MMP-9)
	Cell Signaling Technology (CST) Antibodies for MMP9 (MMP-9)
	Antibodies from Abcam (MMP9), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for MMP9

Assays for MMP9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for MMP9 (MMP-9) (see all)
	Enzo Life Sciences assays for MMP9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14780

ProtoNet protein and cluster: P14780

4 Blocks protein families:

IPB000562 Type II fibronectin collagen-binding domain

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 3 fibronectin type-II domains

Similarity: Contains 4 hemopexin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004994

Applied Biosystems Silencer® siRNAs for MMP9

Sigma-Aldrich siRNA and siRNA Panels for MMP9

Sigma-Aldrich shRNA Panels and shRNA for MMP9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MMP9
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004994
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004994
untagged cDNA clone in CMV expression vector: NM_004994

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004994

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Function: May play an essential role in local proteolysis of the extracellular matrix and in

leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-

-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and

shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide

Catalytic activity: Cleavage of gelatin types I and V and collagen types IV and V

Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5)

Induction: Activated by 4-aminophenylmercuric acetate and phorbol ester

Enzyme Number (IUBMB): EC 3.4.24.35

Genatlas biochemistry entry for MMP9:

matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar

macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing

plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in

mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute

and chronic inflammation of tumoral metastatic process and in injury processus of

myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly

diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by

acting in the remodeling,associated with neovascularization),may be also involved in the severity

of coronary atherosclerosis

11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mmp9):

	growth/size	homeostasis/metabolism	immune system	limbs/digits/tail
muscle	nervous system	renal/urinary system	reproductive system	skeleton
tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IDA	2551898 16192646
GO:0005509	calcium ion binding	IEA	--
GO:0005518	collagen binding	TAS	2251898
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	TAS	2251898

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for MMP9 (Your Favorite Gene powered by Ingenuity) (see all 9 )

HIF1&alpha
Airway Pathology in Chronic Obstructive Pulmonary Disease
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Lysine Degradation
LXR/RXR Activation

GeneDecks MMP9 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MMP9

5/196 Interacting proteins for MMP9 (ENSP00000361405³) via UniProtKB, MINT, and/or STRING (see all 196 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TGFB1	ENSP00000221930³	STRING (score=.995)
THBS1	ENSP00000260356³	STRING (score=.995)
LCN2	ENSP00000362089³	STRING (score=.994)
TIMP1	ENSP00000218388³	STRING (score=.993)
IL1B	ENSP00000263341³	STRING (score=.991)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006508	proteolysis	IDA	2551898
GO:0008152	metabolic process	IEA	--
GO:0030198	extracellular matrix organization	IEA	--
GO:0030225	macrophage differentiation	TAS	2251898

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MMP9

Sigma-Aldrich Small Molecules for MMP9:

Inhibitor

Compounds for MMP9 available from Tocris Bioscience

Compound	Action	CAS number
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

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10/40 Novoseek chemical compound relationships for MMP9 gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	86.35	94	9185711 (2), 12437074 (2), 15572024 (2), 11156083 (2) (see all 69)
(4-aminophenyl)mercuric acetate	76.86	9	7532211 (2), 11986939 (1), 8828413 (1), 15711750 (1) (see all 6)
pck-3145	62.76	8	16550001 (4), 16283486 (3), 16197609 (1)
cgs-27023a	59.88	2	19239231 (1), 15080939 (1)
col 3	54.07	8	12850461 (3), 16205320 (2), 11469893 (1), 17237909 (1) (see all 5)
hydroxamate	49.82	7	19239231 (1), 9873598 (1), 12504900 (1), 7722295 (1) (see all 5)
sikvav	49.18	2	15006619 (1), 7737965 (1)
pd 98,059	46.31	32	12745093 (2), 17234168 (2), 12794156 (2), 11448065 (1) (see all 27)
12-o-tetradecanoylphorbol 13-acetate	40.37	131	15788229 (5), 16380122 (5), 19181503 (5), 1284126 (4) (see all 28)
1,10-phenanthroline	39.51	10	11956628 (2), 10233890 (1), 11426881 (1), 17288807 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004994

Sigma-Aldrich siRNA and siRNA Panels for MMP9

Sigma-Aldrich shRNA Panels and shRNA for MMP9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004994

REFSEQ mRNAs for MMP9 gene:

NM_004994.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004994

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004994
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004994
                                 untagged cDNA clone in CMV expression vector: NM_004994

Additional cDNA sequence:

AK298246.1 AK301446.1 AK302530.1 AK303080.1 AK311648.1 AK313137.1 AK316145.1 BC006093.1

J05070.1

20 DOTS entries:

DT.413883 DT.100024680 DT.95199801 DT.120817295 DT.120817587 DT.120817880 DT.120817870 DT.120817186

DT.120817482 DT.120817723 DT.120817759 DT.120817459 DT.97818783 DT.120817576 DT.100024681 DT.120817176

DT.91731953 DT.92438252 DT.92438254 DT.97790192

24/156 AceView cDNA sequences (see all 156 ):

BI833565 BI836570 R53437 BM707830 BQ705891 F09820 BE503223 BU626262

BQ004583 BP337968 AI968368 BQ706480 BC006093 BV190379 BG684746 BU618090

AW293821 AI860333 CK902116 AU100529 AA653497 BV198164 AW137504 BF432443

highest scoring ESTs for MMP9:

J05070 AA983506 AI445533 AI954665 AI963915 AI968368 AW003537 AW084329 AW132027 AW293821

Unigene Cluster for MMP9:

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Hs.297413 [show with all ESTs]

Unigene Representative Sequence: NM_004994

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000372330

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MMP9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MMP9

¹ / ² / ³

3 probe-sets matching MMP9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31859_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	J05070	1.00	0.90	0.95	1
203936_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004994	0.60	1.00	0.82	1
203936_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MMP9 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATCCCCA

SOURCE GeneReport for Unigene cluster: Hs.297413
Expression variation in blood from EXPOLDB for MMP9
UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780
Tissue specificity: Produced by normal alveolar macrophages and granulocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MMP9 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MMP9¹	--	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, more	85.46(n) 80.97(a)	403885 NM_001003219.1 NP_001003219.1
chimpanzee (Pan troglodytes)	MMP9¹	--	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, more	99.57(n) 99.43(a)	458294 XM_514689.2 XP_514689.2
cow (Bos taurus)	MMP9¹	--	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, more	84.49(n) 80.91(a)	282871 NM_174744.2 NP_777169.1
rat (Rattus norvegicus)	Mmp9¹	--	matrix metallopeptidase 9	79.15(n) 74.89(a)	81687 NM_031055.1 NP_112317.1
mouse (Mus musculus)	Mmp9^{1, 5}	2 (96.00 cM)⁵	matrix metallopeptidase 9^{1, 5}	78.69(n)¹ 75(a)¹	17395¹ NM_013599.2¹ NP_038627.1¹ AF000957⁵ AF403768⁵ (see all 21)

About this table Species with no ortholog for MMP9

ENSEMBL Gene Tree for MMP9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MMP9 gene

MMP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/87 NCBI SNPs in MMP9 are shown (see all 87 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2250889^1,2	C,F,H,O	44075813(+)	`GGAGCC/GGCTCT`	1	R/P	mis¹		28	EA NS EU WA MN NA	3532
	rs3918241^1,2	A,C,F,H	44069142(+)	`GGAAGT/ATAATT`	1	--	ng5¹ tfbs³		17	NS EU EA WA	1360
	rs3918245^1,2	A,C,F,H	44070317(+)	`GAAGAT/GTCAGC`	1	--	ng5¹		26	NS EU EA WA NA	1632
	rs3918278^1,2	C,F,H	44069061(+)	`GGGATG/AGAAAT`	1	--	ng5¹		25	NS EU EA WA	2186
	rs17576^1,2	C,F,H	44073632(+)	`CACCCA/GGGACG`	1	Q/R	mis¹		33	MN NA NS EU EA WA	2508
--	rs3918242^1,2	A,C,F	44069383(+)	`gcgcaC/Tgccta`	1	--	ng5¹		12	NS MN CSAM EA	688
	rs3918252^1,2	C,F,H	44072538(+)	`CAAAAC/GTACTC`	1	N/K	mis¹ ese³		20	NS EU EA WA MN NA	1752
	rs1805088^1,2	C,F,H	44071031(+)	`TGCTGC/TCCCCA`	1	A/V	mis¹		21	EA NA MN NS EU WA	1442
	rs3918244^1,2	C,F,H	44070230(+)	`TAAGAC/TATTTG`	1	--	ng5¹		11	NS EU EA WA	698
--	rs3918240^1,2	A,C,F	44069023(+)	`acttgC/Tccaag`	1	--	ng5¹		7	NS	256

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HapMap Linkage Disequilibrium images for MMP9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 120361 disorders: 603932

UniProtKB/Swiss-Prot: MMP9_HUMAN, P14780

Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH)

[MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain

10/96 Novoseek disease relationships for MMP9 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	81.33	756	9703281 (7), 12452001 (6), 11680936 (6), 12717827 (6) (see all 99)
tumors	77.56	1651	14584660 (7), 10053110 (7), 10831344 (6), 11078794 (6) (see all 99)
atherosclerotic plaque	68.72	58	15585220 (5), 15772219 (4), 12387578 (2), 15583828 (2) (see all 31)
cancer	68.38	424	19141401 (5), 19360311 (5), 12600296 (4), 17034838 (3) (see all 99)
inflammation	68.11	230	15635615 (3), 19218638 (3), 18799677 (3), 10224466 (2) (see all 99)
necrosis	64.48	282	8045973 (2), 9917505 (2), 11306564 (2), 19425365 (2) (see all 99)
aortic aneurysm abdominal	64.21	58	8691515 (2), 19119028 (2), 15765912 (2), 16779512 (2) (see all 35)
fibrosarcoma	63.50	60	15107580 (4), 11673527 (2), 10597035 (2), 17020790 (2) (see all 38)
carcinoma squamous cell	57.56	104	10053110 (4), 12218298 (4), 7850814 (3), 15818624 (3) (see all 68)
atherosclerosis	56.65	65	17194891 (5), 19330590 (3), 12205736 (2), 16574900 (2) (see all 36)

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Human Gene Mutation Database: MMP9
Genetic Association Database: MMP9
Human Genome Epidemiology Navigator: MMP9 (172 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/2961 PubMed articles for MMP9 gene (see all 2961 ):

Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (PubMed id 15316122)^{1, 3, 6} Hulkkonen J....Lehtimaki T. (2004)
Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma. (PubMed id 16026590)^{1, 3, 6} Ganter K....Heinzmann A. (2005)
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (PubMed id 15823277)^{1, 3, 6} Pollanen P.J....Karhunen P.J. (2005)
No association between the C-1562T polymorphism in the promoter of matrix metalloproteinase-9 gene and non-small cell lung carcinoma. (PubMed id 15949868)^{1, 3, 6} Wang Y....Zhang J. (2005)
Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. (PubMed id 15748780)^{1, 3, 6} Shibata N....Arai H. (2005)
Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis. (PubMed id 15691353)^{1, 3, 6} de Souza A.P....Line S.R. (2005)
A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer. (PubMed id 15565457)^{1, 3, 6} Matsumura S....Yasui W. (2005)
[Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2) and MMP-9 genes with risk of gastric cancer in a Chinese population.] (PubMed id 15522165)^{1, 3, 6} Zhang X.M....Lin D.X. (2004)
Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure. (PubMed id 14982353)^{1, 3, 6} Santos M.C....Line S.R. (2004)
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. (PubMed id 1371271)^{1, 3, 4} Ogata Y.... Nagase H. (1992)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4318	HGNC: 7176	AceView: MMP9	Ensembl:ENSG00000100985	euGenes: HUgn4318
ECgene: MMP9	H-InvDB: MMP9

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MMP9	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp9/
SeattleSNPs	http://pga.gs.washington.edu/data/mmp9/

Licensable Technologies for MMP9
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MMP9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MMP9-related products

	Millipore Custom Antibody & Bulk Services
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Search OriGene for MMP9

Tocris compounds for MMP9

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MMP9

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MMP9 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for MMP9

Summaries
for MMP9

Genomic Location
for MMP9

Proteins
for MMP9

Protein Domains/
Families
for MMP9

Gene Function
for MMP9

Pathways & Interactions
for MMP9

Drugs & Compounds
for MMP9

Transcripts
for MMP9

Expression
for MMP9

Orthologs
for MMP9

Paralogs
for MMP9

SNPs/Variants
for MMP9

Disorders & Mutations
for MMP9

Medical News
for MMP9

Publications
for MMP9

Search for MMP9

Genome Databases showing MMP9

Other Databases showing MMP9

Specialized Databases showing MMP9

Licensable Technologies
for MMP9

Services
for MMP9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MMP9 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor MMP9

Summariesfor MMP9

Genomic Locationfor MMP9

Proteinsfor MMP9

Protein Domains/Familiesfor MMP9

Gene Functionfor MMP9

Pathways & Interactionsfor MMP9

Drugs & Compoundsfor MMP9

Transcriptsfor MMP9

Expression for MMP9

Orthologsfor MMP9

Paralogsfor MMP9

SNPs/Variantsfor MMP9

Disorders & Mutationsfor MMP9

Medical Newsfor MMP9

Publicationsfor MMP9

Search for MMP9

Genome Databases showing MMP9

Other Databases showing MMP9

Specialized Databases showing MMP9

Licensable Technologiesfor MMP9

Servicesfor MMP9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MMP9

Summaries
for MMP9

Genomic Location
for MMP9

Proteins
for MMP9

Protein Domains/
Families
for MMP9

Gene Function
for MMP9

Pathways & Interactions
for MMP9

Drugs & Compounds
for MMP9

Transcripts
for MMP9

Expression
for MMP9

Orthologs
for MMP9

Paralogs
for MMP9

SNPs/Variants
for MMP9

Disorders & Mutations
for MMP9

Medical News
for MMP9

Publications
for MMP9

Licensable Technologies
for MMP9

Services
for MMP9