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Aliases for MMP9 Gene

Aliases for MMP9 Gene

  • Matrix Metallopeptidase 9 2 3 5
  • Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 2 3
  • EC 3.4.24.35 4 63
  • CLG4B 3 4
  • MMP-9 3 4
  • GELB 3 4
  • Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 3
  • 92 KDa Type IV Collagenase 4
  • Macrophage Gelatinase 3
  • Type V Collagenase 3
  • 92 KDa Gelatinase 4
  • Gelatinase B 4
  • EC 3.4.24 63
  • MANDP2 3

External Ids for MMP9 Gene

Previous HGNC Symbols for MMP9 Gene

  • CLG4B

Previous GeneCards Identifiers for MMP9 Gene

  • GC20P044366
  • GC20P045275
  • GC20P045322
  • GC20P044070
  • GC20P044637
  • GC20P041378

Summaries for MMP9 Gene

Entrez Gene Summary for MMP9 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP9 Gene

MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include metaphyseal anadysplasia 2 and metaphyseal anadysplasia. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include identical protein binding and metalloendopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP9 Gene

  • May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Tocris Summary for MMP9 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP9 Gene

Genomics for MMP9 Gene

Regulatory Elements for MMP9 Gene

Promoters for MMP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP9 Gene

Chromosome:
20
Start:
46,008,908 bp from pter
End:
46,016,561 bp from pter
Size:
7,654 bases
Orientation:
Plus strand

Genomic View for MMP9 Gene

Genes around MMP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP9 Gene

Proteins for MMP9 Gene

  • Protein details for MMP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14780-MMP9_HUMAN
    Recommended name:
    Matrix metalloproteinase-9
    Protein Accession:
    P14780
    Secondary Accessions:
    • B2R7V9
    • Q3LR70
    • Q8N725
    • Q9H4Z1
    • Q9UCJ9
    • Q9UCL1
    • Q9UDK2

    Protein attributes for MMP9 Gene

    Size:
    707 amino acids
    Molecular mass:
    78458 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
    Miscellaneous:
    • In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.

    Three dimensional structures from OCA and Proteopedia for MMP9 Gene

neXtProt entry for MMP9 Gene

Proteomics data for MMP9 Gene at MOPED

Post-translational modifications for MMP9 Gene

  • N- and O-glycosylated.
  • Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  • Glycosylation at Asn 38, Asn 120, and Asn 127
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP9 (MMP9)

Protein Products

Domains & Families for MMP9 Gene

Gene Families for MMP9 Gene

Suggested Antigen Peptide Sequences for MMP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14780

UniProtKB/Swiss-Prot:

MMP9_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 3 fibronectin type-II domains.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP9: view

Function for MMP9 Gene

Molecular function for MMP9 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of gelatin types I and V and collagen types IV and V.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
UniProtKB/Swiss-Prot Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
UniProtKB/Swiss-Prot Induction:
Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.

Enzyme Numbers (IUBMB) for MMP9 Gene

Gene Ontology (GO) - Molecular Function for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,TAS --
GO:0042802 identical protein binding IPI 23601700
genes like me logo Genes that share ontologies with MMP9: view
genes like me logo Genes that share phenotypes with MMP9: view

Human Phenotype Ontology for MMP9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MMP9 Gene

MGI Knock Outs for MMP9:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP9

No data available for Transcription Factor Targets and HOMER Transcription for MMP9 Gene

Localization for MMP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP9 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP9 Gene COMPARTMENTS Subcellular localization image for MMP9 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 4
cytoskeleton 3
cytosol 3
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MMP9 Gene

Pathways & Interactions for MMP9 Gene

genes like me logo Genes that share pathways with MMP9: view

SIGNOR curated interactions for MMP9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006508 proteolysis IEA,IDA 2551898
GO:0007411 axon guidance TAS --
GO:0007566 embryo implantation IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with MMP9: view

Drugs & Compounds for MMP9 Gene

(90) Drugs for MMP9 Gene - From: Novoseek, HMDB, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
Minocycline Approved, Investigational Pharma 173
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 493
Zinc Approved Pharma 1477
Captopril Approved Pharma Inhibition, Inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 29

(67) Additional Compounds for MMP9 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP9: view

Drug Products

Transcripts for MMP9 Gene

mRNA/cDNA for MMP9 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP9 Gene

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP9 Gene

No ASD Table

Relevant External Links for MMP9 Gene

GeneLoc Exon Structure for
MMP9
ECgene alternative splicing isoforms for
MMP9

Expression for MMP9 Gene

mRNA expression in normal human tissues for MMP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP9 Gene

This gene is overexpressed in Whole Blood (x46.3).

Protein differential expression in normal tissues from HIPED for MMP9 Gene

This gene is overexpressed in Neutrophil (45.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP9 Gene



SOURCE GeneReport for Unigene cluster for MMP9 Gene Hs.297413

mRNA Expression by UniProt/SwissProt for MMP9 Gene

P14780-MMP9_HUMAN
Tissue specificity: Produced by normal alveolar macrophages and granulocytes.
genes like me logo Genes that share expression patterns with MMP9: view

Protein tissue co-expression partners for MMP9 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MMP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP9 35
  • 83.55 (n)
  • 79.49 (a)
MMP9 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP9 35
  • 84.37 (n)
  • 79.83 (a)
MMP-9 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp9 35
  • 78.36 (n)
  • 74.72 (a)
Mmp9 16
Mmp9 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP9 35
  • 99.57 (n)
  • 99.43 (a)
MMP9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp9 35
  • 78.77 (n)
  • 74.47 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP9 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MMP9 35
  • 67.32 (n)
  • 63.14 (a)
MMP9 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494738 35
  • 60.26 (n)
  • 59.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69080 35
zebrafish
(Danio rerio)
Actinopterygii mmp9 35
  • 60.77 (n)
  • 60.31 (a)
wufb02g06 35
mmp9 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10476 35
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 22 (a)
ManyToMany
zmp-1 36
  • 21 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45040 35
  • 46.18 (n)
  • 35.32 (a)
Species with no ortholog for MMP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP9 Gene

ENSEMBL:
Gene Tree for MMP9 (if available)
TreeFam:
Gene Tree for MMP9 (if available)

Paralogs for MMP9 Gene

Paralogs for MMP9 Gene

(1) SIMAP similar genes for MMP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP9: view

Variants for MMP9 Gene

Sequence variations from dbSNP and Humsavar for MMP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1805088 - 46,008,985(+) TGCTG(C/T)CCCCA reference, missense
rs1805089 - 46,009,971(+) TGCCC(A/G)AGACC reference, missense
rs17576 - 46,011,586(+) CACCC(A/G)GGACG reference, missense
rs17577 - 46,014,472(+) GTACC(A/C/G)AGGTG reference, missense
rs3918252 - 46,010,492(+) CAAAA(C/G)TACTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP9 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV Loss 17160897

Variation tolerance for MMP9 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.70; 97.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP9 Gene

HapMap Linkage Disequilibrium report
MMP9
Human Gene Mutation Database (HGMD)
MMP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP9 Gene

Disorders for MMP9 Gene

MalaCards: The human disease database

(157) MalaCards diseases for MMP9 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
metaphyseal anadysplasia 2
  • mandp2
metaphyseal anadysplasia
  • mad
abdominal aortic aneurysm
  • aortic aneurysm, familial abdominal 1
middle ear squamous cell carcinoma
  • epidermoid carcinoma of the middle ear
eosinophilic meningitis
- elite association - COSMIC cancer census association via MalaCards
Search MMP9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP9_HUMAN
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. {ECO:0000269 PubMed:19615667}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MMP9

Genetic Association Database (GAD)
MMP9
Human Genome Epidemiology (HuGE) Navigator
MMP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP9
genes like me logo Genes that share disorders with MMP9: view

No data available for Genatlas for MMP9 Gene

Publications for MMP9 Gene

  1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y. … Ikegawa S. (Am. J. Hum. Genet. 2008) 3 4 48 67
  2. Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. (PMID: 19700239) Kenig S. … Lah T.T. (Cancer Lett. 2010) 3 23
  3. Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants. (PMID: 19755933) Natarajan G. … Carlo W.A. (Pediatr. Res. 2010) 3 23
  4. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. (PMID: 19804834) Chiu W.T. … Chen Y.C. (Neurobiol. Dis. 2010) 3 23
  5. Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes. (PMID: 20149706) Kadoglou N.P. … Angelopoulou N. (Diabetes Metab. 2010) 3 23

Products for MMP9 Gene

Sources for MMP9 Gene

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