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Aliases for MMP9 Gene

Aliases for MMP9 Gene

  • Matrix Metallopeptidase 9 2 3
  • CLG4B 3 4 6
  • Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 2 3
  • EC 3.4.24.35 4 63
  • MANDP2 3 6
  • MMP-9 3 4
  • GELB 3 4
  • Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) 3
  • Matrix Metalloproteinase-9 3
  • 92 KDa Type IV Collagenase 4
  • Macrophage Gelatinase 3
  • Type V Collagenase 3
  • 92 KDa Gelatinase 4
  • Gelatinase B 4
  • EC 3.4.24 63

External Ids for MMP9 Gene

Previous Symbols for MMP9 Gene

  • CLG4B

Summaries for MMP9 Gene

Entrez Gene Summary for MMP9 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP9 Gene

MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include metaphyseal anadysplasia 2 and metaphyseal anadysplasia. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include identical protein binding and collagen binding. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP9 Gene

  • May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Tocris Summary for MMP9 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP9 Gene

Genomics for MMP9 Gene

Genomic Location for MMP9 Gene

Start:
46,008,908 bp from pter
End:
46,016,561 bp from pter
Size:
7,654 bases
Orientation:
Plus strand

Genomic View for MMP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP9 Gene

Regulatory Elements for MMP9 Gene

Proteins for MMP9 Gene

  • Protein details for MMP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14780-MMP9_HUMAN
    Recommended name:
    Matrix metalloproteinase-9
    Protein Accession:
    P14780
    Secondary Accessions:
    • B2R7V9
    • Q3LR70
    • Q8N725
    • Q9H4Z1
    • Q9UCJ9
    • Q9UCL1
    • Q9UDK2

    Protein attributes for MMP9 Gene

    Size:
    707 amino acids
    Molecular mass:
    78458 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
    Miscellaneous:
    • In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status

    Three dimensional structures from OCA and Proteopedia for MMP9 Gene

neXtProt entry for MMP9 Gene

Proteomics data for MMP9 Gene at MOPED

Post-translational modifications for MMP9 Gene

  • N- and O-glycosylated.
  • Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  • Glycosylation at Asn38, Asn120, and Asn127

Other Protein References for MMP9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MMP9 Gene

Suggested Antigen Peptide Sequences for MMP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14780

UniProtKB/Swiss-Prot:

MMP9_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • P14780
  • Contains 3 fibronectin type-II domains.:
    • P14780
Family:
  • Belongs to the peptidase M10A family.:
    • P14780
Similarity:
  • Contains 4 hemopexin repeats.:
    • P14780
genes like me logo Genes that share domains with MMP9: view

Function for MMP9 Gene

Molecular function for MMP9 Gene

GENATLAS Biochemistry: matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of gelatin types I and V and collagen types IV and V.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
UniProtKB/Swiss-Prot Function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
UniProtKB/Swiss-Prot Induction: Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.

Enzyme Numbers (IUBMB) for MMP9 Gene

Gene Ontology (GO) - Molecular Function for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 19022250
GO:0004222 metalloendopeptidase activity IDA 16192646
GO:0005515 protein binding IPI 16512877
GO:0005518 collagen binding TAS 2251898
GO:0008233 peptidase activity --
genes like me logo Genes that share ontologies with MMP9: view
genes like me logo Genes that share phenotypes with MMP9: view

Animal Models for MMP9 Gene

MGI Knock Outs for MMP9:

miRNA for MMP9 Gene

miRTarBase miRNAs that target MMP9

No data available for Transcription Factor Targeting and HOMER Transcription for MMP9 Gene

Localization for MMP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP9 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP9 Gene COMPARTMENTS Subcellular localization image for MMP9 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2
mitochondrion 2
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 2251898
GO:0031012 extracellular matrix --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MMP9: view

Pathways for MMP9 Gene

genes like me logo Genes that share pathways with MMP9: view

Gene Ontology (GO) - Biological Process for MMP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006508 proteolysis IDA 15863497
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with MMP9: view

Compounds for MMP9 Gene

(15) ApexBio Compounds for MMP9 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2. [704888-90-4]
ARP 101 Selective inhibitor of MMP-2. [849773-63-3]
Batimastat (BB-94) potent and synthetic inhibitor of a broad spectrum of MMPs [130370-60-4]
CL 82198 hydrochloride Selective inhibitor of MMP-13. [307002-71-7]
CP 471474 Broad spectrum MMP inhibitor. [210755-45-6]
CTS-1027 potent small molecule inhibitor of MMPs. [193022-04-7]
GM 6001 Broad-spectrum MMP inhibitor. [142880-36-2]
Marimastat Broad spectrum inhibitor of MMPs. [154039-60-8]
NSC 405020 novel small molecule inhibitor of MT1-MMP [7497-7-6]
ONO 4817 Broad spectrum MMP inhibitor. [223472-31-9]
PD 166793 Broad spectrum MMP inhibitor. [199850-67-4]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor. [190648-49-8]
UK 356618 Potent and selective inhibitor of MMP-3. [230961-08-7]
UK 370106 Highly selective MMP-3 and MMP-12 inhibitor. [230961-21-4]
WAY 170523 Potent and selective inhibitor of MMP-13. [307002-73-9]

(5) Tocris Compounds for MMP9 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(3) HMDB Compounds for MMP9 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Simvastatin
  • (+)-Simvastatin
79902-63-9
Zinc
  • Zinc
7440-66-6

(140) Novoseek inferred chemical compound relationships for MMP9 Gene

Compound -log(P) Hits PubMed IDs
matrigel 86.9 89
vegf 78 429
(4-aminophenyl)mercuric acetate 76.8 7
batimastat 69.7 5
pck-3145 61.2 8
genes like me logo Genes that share compounds with MMP9: view

Transcripts for MMP9 Gene

mRNA/cDNA for MMP9 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP9 Gene

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP9 Gene

No ASD Table

Relevant External Links for MMP9 Gene

GeneLoc Exon Structure for
MMP9
ECgene alternative splicing isoforms for
MMP9

Expression for MMP9 Gene

mRNA expression in normal human tissues for MMP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP9 Gene

This gene is overexpressed in Whole Blood (46.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP9 Gene

SOURCE GeneReport for Unigene cluster for MMP9 Gene Hs.297413

mRNA Expression by UniProt/SwissProt for MMP9 Gene

P14780-MMP9_HUMAN
Tissue specificity: Produced by normal alveolar macrophages and granulocytes
genes like me logo Genes that share expressions with MMP9: view

Orthologs for MMP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP9 35
  • 99.57 (n)
  • 99.43 (a)
MMP9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP9 35
  • 83.55 (n)
  • 79.49 (a)
MMP9 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP-9 36
  • 81 (a)
OneToOne
MMP9 35
  • 84.37 (n)
  • 79.83 (a)
mouse
(Mus musculus)
Mammalia Mmp9 35
  • 78.36 (n)
  • 74.72 (a)
Mmp9 16
Mmp9 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP9 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mmp9 35
  • 78.77 (n)
  • 74.47 (a)
chicken
(Gallus gallus)
Aves MMP9 35
  • 67.32 (n)
  • 63.14 (a)
MMP9 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC69080 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494738 35
  • 60.26 (n)
  • 59.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10476 35
zebrafish
(Danio rerio)
Actinopterygii mmp9 35
  • 60.77 (n)
  • 60.31 (a)
mmp9 36
  • 59 (a)
OneToOne
wufb02g06 35
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 22 (a)
ManyToMany
zmp-1 36
  • 21 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45040 35
  • 46.18 (n)
  • 35.32 (a)
Species with no ortholog for MMP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP9 Gene

ENSEMBL:
Gene Tree for MMP9 (if available)
TreeFam:
Gene Tree for MMP9 (if available)

Paralogs for MMP9 Gene

Paralogs for MMP9 Gene

Selected SIMAP similar genes for MMP9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP9: view

Variants for MMP9 Gene

Sequence variations from dbSNP and Humsavar for MMP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9509 -- 46,016,514(+) ACCTT(C/T)GTTTT utr-variant-3-prime
rs13925 -- 46,016,326(+) CAAGT(A/G)GGCTA synonymous-codon, reference
rs13969 -- 46,014,194(+) CTGGG(A/C)GCCGA reference, synonymous-codon
rs17576 - 46,011,586(+) CACCC(A/G)GGACG reference, missense
rs17577 - 46,014,472(+) GTACC(A/C/G)AGGTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MMP9 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV Loss 17160897

Relevant External Links for MMP9 Gene

HapMap Linkage Disequilibrium report
MMP9
Human Gene Mutation Database (HGMD)
MMP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP9 Gene

Disorders for MMP9 Gene

(1) OMIM Diseases for MMP9 Gene (120361)

UniProtKB/Swiss-Prot

MMP9_HUMAN
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Note=The disease is caused by mutations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for MMP9 Gene

Disease -log(P) Hits PubMed IDs
metastasis 81.9 285
tumors 78.3 376
cancer 70 173
inflammation 69.7 127
atherosclerotic plaque 69.7 61

Relevant External Links for MMP9

Genetic Association Database (GAD)
MMP9
Human Genome Epidemiology (HuGE) Navigator
MMP9
genes like me logo Genes that share disorders with MMP9: view

Publications for MMP9 Gene

  1. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. (PMID: 1400481) Okada Y. … Hayakawa T. (J. Biol. Chem. 1992) 3 4 23
  2. Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis. (PMID: 11410119) Wang J. … Wang X.L. (Clin. Sci. 2001) 3 23 48
  3. Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study. (PMID: 11557670) PAPllAonen P.J. … LehtimAoki T. (Arterioscler. Thromb. Vasc. Biol. 2001) 3 23 48
  4. Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. (PMID: 11708786) Minematsu N. … Yamaguchi K. (Biochem. Biophys. Res. Commun. 2001) 3 23 48
  5. Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention. (PMID: 11916008) Cho H.J. … Park Y.B. (J. Hum. Genet. 2002) 3 23 48

Products for MMP9 Gene

Sources for MMP9 Gene

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