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Aliases for MMP8 Gene

Aliases for MMP8 Gene

  • Matrix Metallopeptidase 8 2 3
  • CLG1 3 4 6
  • Matrix Metalloproteinase 8 (Neutrophil Collagenase) 2 3
  • Matrix Metalloproteinase-8 3 4
  • PMNL Collagenase 3 4
  • PMNL-CL 3 4
  • MMP-8 3 4
  • PMN Leukocyte Collagenase 3
  • Neutrophil Collagenase 3
  • Collagenase 2 3
  • EC 3.4.24.34 4
  • EC 3.4.24 63
  • HNC 3

External Ids for MMP8 Gene

Previous HGNC Symbols for MMP8 Gene

  • CLG1

Previous GeneCards Identifiers for MMP8 Gene

  • GC11M104777
  • GC11M103940
  • GC11M102121
  • GC11M102088
  • GC11M098509

Summaries for MMP8 Gene

Entrez Gene Summary for MMP8 Gene

  • This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MMP8 Gene

MMP8 (Matrix Metallopeptidase 8) is a Protein Coding gene. Diseases associated with MMP8 include preterm premature rupture of the membranes and periapical granuloma. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP8 Gene

  • Can degrade fibrillar type I, II, and III collagens

Tocris Summary for MMP8 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP8 Gene

Genomics for MMP8 Gene

Regulatory Elements for MMP8 Gene

Genomic Location for MMP8 Gene

Start:
102,711,795 bp from pter
End:
102,727,050 bp from pter
Size:
15,256 bases
Orientation:
Minus strand

Genomic View for MMP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP8 Gene

Proteins for MMP8 Gene

  • Protein details for MMP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22894-MMP8_HUMAN
    Recommended name:
    Neutrophil collagenase
    Protein Accession:
    P22894
    Secondary Accessions:
    • Q45F99

    Protein attributes for MMP8 Gene

    Size:
    467 amino acids
    Molecular mass:
    53412 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP8 Gene

neXtProt entry for MMP8 Gene

Proteomics data for MMP8 Gene at MOPED

Selected DME Specific Peptides for MMP8 Gene

Post-translational modifications for MMP8 Gene

  • Glycosylation at Asn54, Asn73, Asn112, Asn204, and Asn246
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP8 Gene

Antibody Products

Protein Products

Assay Products

  • Enzo Life Sciences assays for MMP8
  • antibodies-online kits for MMP8

Domains for MMP8 Gene

Suggested Antigen Peptide Sequences for MMP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22894

UniProtKB/Swiss-Prot:

MMP8_HUMAN :
  • P22894
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP8: view

Function for MMP8 Gene

Molecular function for MMP8 Gene

GENATLAS Biochemistry: matrix metalloproteinase 8,regulator in matrix remodeling,MMP cluster
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I
UniProtKB/Swiss-Prot EnzymeRegulation: Cannot be activated without removal of the activation peptide
UniProtKB/Swiss-Prot Function: Can degrade fibrillar type I, II, and III collagens

Enzyme Numbers (IUBMB) for MMP8 Gene

Gene Ontology (GO) - Molecular Function for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity IDA 16192646
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding TAS 2164002
genes like me logo Genes that share ontologies with MMP8: view

Phenotypes for MMP8 Gene

MGI mutant phenotypes for MMP8:
inferred from 1 alleles
GenomeRNAi human phenotypes for MMP8:
genes like me logo Genes that share phenotypes with MMP8: view

Animal Models for MMP8 Gene

MGI Knock Outs for MMP8:

Animal Model Products

CRISPR Products

miRNA for MMP8 Gene

miRTarBase miRNAs that target MMP8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP8

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MMP8 Gene

Localization for MMP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP8 Gene

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP8 Gene COMPARTMENTS Subcellular localization image for MMP8 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 2164002
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP8: view

Pathways for MMP8 Gene

genes like me logo Genes that share pathways with MMP8: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 2164002
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
GO:0035987 endodermal cell differentiation IEP 23154389
genes like me logo Genes that share ontologies with MMP8: view

Compounds for MMP8 Gene

Compound Products

(15) ApexBio Compounds for MMP8 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2. [704888-90-4]
ARP 101 Selective inhibitor of MMP-2. [849773-63-3]
Batimastat (BB-94) potent and synthetic inhibitor of a broad spectrum of MMPs [130370-60-4]
CL 82198 hydrochloride Selective inhibitor of MMP-13. [307002-71-7]
CP 471474 Broad spectrum MMP inhibitor. [210755-45-6]
CTS-1027 potent small molecule inhibitor of MMPs. [193022-04-7]
GM 6001 Broad-spectrum MMP inhibitor. [142880-36-2]
Marimastat Broad spectrum inhibitor of MMPs. [154039-60-8]
NSC 405020 novel small molecule inhibitor of MT1-MMP [7497-7-6]
ONO 4817 Broad spectrum MMP inhibitor. [223472-31-9]
PD 166793 Broad spectrum MMP inhibitor. [199850-67-4]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor. [190648-49-8]
UK 356618 Potent and selective inhibitor of MMP-3. [230961-08-7]
UK 370106 Highly selective MMP-3 and MMP-12 inhibitor. [230961-21-4]
WAY 170523 Potent and selective inhibitor of MMP-13. [307002-73-9]

(5) Tocris Compounds for MMP8 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP8 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(44) Novoseek inferred chemical compound relationships for MMP8 Gene

Compound -log(P) Hits PubMed IDs
phenylmercuric chloride 73.3 1
doxycycline 68.4 40
hydroxamate 65.7 4
batimastat 58.9 2
(4-aminophenyl)mercuric acetate 55 1
genes like me logo Genes that share compounds with MMP8: view

Transcripts for MMP8 Gene

Unigene Clusters for MMP8 Gene

Matrix metallopeptidase 8 (neutrophil collagenase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for MMP8 Gene

GeneLoc Exon Structure for
MMP8
ECgene alternative splicing isoforms for
MMP8

Expression for MMP8 Gene

mRNA expression in normal human tissues for MMP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP8 Gene

This gene is overexpressed in Whole Blood (48.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP8 Gene

SOURCE GeneReport for Unigene cluster for MMP8 Gene Hs.161839

mRNA Expression by UniProt/SwissProt for MMP8 Gene

P22894-MMP8_HUMAN
Tissue specificity: Neutrophils
genes like me logo Genes that share expressions with MMP8: view

In Situ Assay Products

Orthologs for MMP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP8 35
  • 99.07 (n)
  • 98.5 (a)
MMP8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP8 35
  • 83.19 (n)
  • 76.61 (a)
MMP8 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP8 35
  • 83.11 (n)
  • 79.69 (a)
MMP8 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp8 35
  • 80.01 (n)
  • 74.24 (a)
Mmp8 16
Mmp8 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP8 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP8 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp8 35
  • 79.81 (n)
  • 73.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mmp13a 35
  • 57.16 (n)
  • 48.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 39 (a)
Species with no ortholog for MMP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMP8 Gene

ENSEMBL:
Gene Tree for MMP8 (if available)
TreeFam:
Gene Tree for MMP8 (if available)

Paralogs for MMP8 Gene

Selected SIMAP similar genes for MMP8 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MMP8 Gene

genes like me logo Genes that share paralogs with MMP8: view

Variants for MMP8 Gene

Sequence variations from dbSNP and Humsavar for MMP8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948218 -- 102,722,311(+) ACTCT(A/T)CAAAG intron-variant
rs1276282 -- 102,712,663(-) CATAG(C/T)CACCT utr-variant-3-prime
rs1291327 -- 102,712,642(-) GCCGT(A/G)TGAAG utr-variant-3-prime
rs1320632 -- 102,725,332(+) ACTTA(C/T)CCTCC upstream-variant-2KB
rs1892886 -- 102,721,263(-) TTTGC(A/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP8 Gene

Variant ID Type Subtype PubMed ID
nsv832252 CNV Gain 17160897

Relevant External Links for MMP8 Gene

HapMap Linkage Disequilibrium report
MMP8
Human Gene Mutation Database (HGMD)
MMP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP8 Gene

Disorders for MMP8 Gene

(6) University of Copenhagen DISEASES for MMP8 Gene

(66) Novoseek inferred disease relationships for MMP8 Gene

Disease -log(P) Hits PubMed IDs
chronic periodontitis 69.5 10
periodontal diseases 67.9 25
gingivitis 61.7 12
gingival pocket 51.8 1
gingival bleeding 51.5 1

Relevant External Links for MMP8

Genetic Association Database (GAD)
MMP8
Human Genome Epidemiology (HuGE) Navigator
MMP8
genes like me logo Genes that share disorders with MMP8: view

No data available for UniProtKB/Swiss-Prot for MMP8 Gene

Publications for MMP8 Gene

  1. Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. (PMID: 2164002) Hasty K.A. … Mainardi C.L. (J. Biol. Chem. 1990) 3 4 23
  2. Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). (PMID: 15367487) Wang H. … Strauss J.F. (Hum. Mol. Genet. 2004) 3 23 48
  3. Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase. (PMID: 2176876) Mallya S.K. … van Wart H.E. (Biochemistry 1990) 3 4 23
  4. Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. (PMID: 17974962) Decock J. … Ye S. (Cancer Res. 2007) 3 23 48
  5. Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. (PMID: 19094243) GonzA!lez-Arriaga P. … TardA^n A. (BMC Cancer 2008) 3 23 48

Products for MMP8 Gene

  • Addgene plasmids for MMP8

Sources for MMP8 Gene

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