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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP8 Gene

protein-coding GIFtS: 72
GCID: GC11M102617

matrix metallopeptidase 8 (neutrophil collagenase)

(Previous name: matrix metalloproteinase 8 (neutrophil collagenase) )
(Previous symbol: CLG1)

Explore 96 diseases affiliated with
MMP8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 8 (Neutrophil Collagenase)¹ ²		PMNL Collagenase² ³
CLG1¹ ² ³ ⁵		HNC²
Matrix Metalloproteinase 8 (Neutrophil Collagenase)¹ ²		Neutrophil Collagenase²
Matrix Metalloproteinase-8² ³		EC 3.4.24.34³
MMP-8² ³		EC 3.4.24⁸
PMNL-CL² ³

External Ids:	HGNC: 7175¹	Entrez Gene: 4317²	Ensembl: ENSG00000118113⁷	OMIM: 120355⁵	UniProtKB: P22894³

Export aliases for MMP8 gene to outside databases

Previous GC identifers: GC11M104777 GC11M103940 GC11M102121 GC11M102088 GC11M098509

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP8:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within

neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The

gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894

Function: Can degrade fibrillar type I, II, and III collagens

summary for MMP8:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP8 gene promoter:
SRF SRF (504 AA) p300 MEF-2A PPAR-gamma1 c-Rel FOXO4 aMEF-2 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP8 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q21-q22

MMP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP8 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102617: view genomic region (about GC identifiers)

Start:	102,582,526 bp from pter	End:	102,597,781 bp from pter
Size:	15,256 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894 (See protein sequence)

Recommended Name: Neutrophil collagenase precursor

Size: 467 amino acids; 53412 Da

Cofactor: Binds 3 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subcellular location: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix (Probable). Note=Stored

in intracellular granules

6/23 PDB 3D structures from and Proteopedia for MMP8 (see all 23):

1A85 (3D)

1A86 (3D)

1BZS (3D)

1I73 (3D)

1I76 (3D)

1JAN (3D)

Secondary accessions: Q45F99

Explore the universe of human proteins at neXtProt for MMP8: NX_P22894

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22894

4/6 DME Specific Peptides for MMP8 (P22894) (see all 6)

LTFDAIT

DNSPFDG

PRCGVPD

VAAHEFGH

MMP8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002415.1

ENSEMBL proteins:

ENSP00000236826 ENSP00000431431 ENSP00000401004 ENSP00000437173 ENSP00000433812

ENSP00000431938

Reactome Protein details: P22894
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for MMP8
	Novus Biologicals MMP8 Proteins Novus Biologicals MMP8 Lysate
	Sino Biological Recombinant Protein for MMP8
	ProSpec Recombinant Protein for MMP8
	Uscn Proteins for MMP8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	2164002

MMP8 for ontologies About GeneDecksing

MMP8 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP8
	R&D Systems Antibodies for MMP8 (MMP-8)
	OriGene Antibodies: MMP8 OriGene Custom Antibody Services for MMP8
	GenScript Custom Superior Antibodies Services for MMP8
	Novus Biologicals MMP8 Antibodies
	Abcam antibodies for MMP8
	Uscn Antibodies for MMP8
	ThermoFisher Antibodies for MMP8

Assay Products for MMP8:

	EMD Millipore Kits and Assays for the Analysis of MMP8
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP8 (MMP-8) (see all)
	GenScript MMP8-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP8
	Uscn ELISAs and CLIAs for MMP8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP8 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P22894

ProtoNet protein and cluster: P22894

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894

Function: Can degrade fibrillar type I, II, and III collagens

Catalytic activity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme

cleaves type III collagen more slowly than type I

Enzyme regulation: Cannot be activated without removal of the activation peptide

Genatlas biochemistry entry for MMP8:

matrix metalloproteinase 8,regulator in matrix remodeling,MMP cluster

Enzyme Numbers (IUBMB): EC 3.4.24² EC 3.4.24.34¹

miRNA Products:		OriGene 3'-UTR Clone: MMP8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP8
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP8:
		hsa-miR-502-5p hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-500a
		SwitchGear 3'UTR luciferase reporter plasmid: MMP8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP8 (see all 7) OriGene shRNA RFP: MMP8 OriGene siRNA: MMP8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP8

Gene Editing
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DNA2.0 Custom Protein Engineering Service for MMP8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: MMP8 (NM_002424)
		Sino Biological Human cDNA Clone for MMP8
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP8
		Search LifeMap BioReagents cell lines for MMP8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP8

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0004252	serine-type endopeptidase activity	IDA	2164002
GO:0005509	calcium ion binding	IEA	--
GO:0008237	metallopeptidase activity	--	--
GO:0008270	zinc ion binding	TAS	2164002

MMP8 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MMP8:

Decreased Salmonella enterica

Animal Models:
Mouse knock-outs for MMP8: Mmp8^tm1Lex Mmp8^tm1Lotn
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp8):

immune system

tumorigenesis

MMP8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

Integrin Pathway

UPA-UPAR Pathway

0.51

Transendothelial Migration of Leukocytes

0.38

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Activation of proMMP8

Activation of proMMP8

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MMP8

	Selected targets of C/EBPalpha
	Metalloproteases in connective tissue degradation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP8

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 BioSystems Pathway for MMP8

Matrix Metalloproteinases

5/6 Reactome Pathways for MMP8 (see all 6)

	Activation of proMMP8
	Extracellular matrix organization
	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
	Degradation of the extracellular matrix
	Degradation of collagen

MMP8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP8

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for MMP8 (P22894³ ENSP00000236826⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCL2	P13500³, ENSP00000225831⁴	I2D: score=1 STRING: ENSP00000225831
UMOD	P07911³, ENSP00000306279⁴	I2D: score=1 STRING: ENSP00000306279
TFPI	P10646³, ENSP00000233156⁴	I2D: score=1 STRING: ENSP00000233156
TIMP2	P16035³, ENSP00000262768⁴	I2D: score=1 STRING: ENSP00000262768
BCAN	Q96GW7³, ENSP00000331210⁴	I2D: score=2 STRING: ENSP00000331210

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	--	--
GO:0006508	proteolysis	IDA	2164002
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030574	collagen catabolic process	IEA	--

MMP8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP8 for compounds About GeneDecksing

EMD Millipore small molecules for MMP8:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP8

Compounds for MMP8 available from Tocris Bioscience About this table

Compound	Action	CAS #
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Ro 32-3555	Potent, collagenase-selective MMP inhibitor	[190648-49-8]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]

1 HMDB Compound for MMP8 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/15 DrugBank Compounds for MMP8 (see all 15) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-Hydroxyamine-2-Isobutylmalonic Acid	--	--	target	--	17139284 17016423 10592235
2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid	--	--	target	--	17139284 17016423 10592235
2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione	--	--	target	--	17139284 17016423 10592235
2-Thiomethyl-3-Phenylpropanoic Acid	--	--	target	--	17139284 17016423 10592235
Batimastat	--	130370-60-4	target	--	17139284 17016423 10592235
Glycinamid	--	--	target	--	17139284 17016423
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951
(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID	--	--	target	--	10592235
(1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID	--	--	target	--	10592235
(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide	--	--	target	--	10592235

10/44 Novoseek chemical compound relationships for MMP8 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phenylmercuric chloride	73.3	1	2171513 (1)
doxycycline	68.4	54	16411105 (6), 10366106 (4), 17122880 (3), 9395486 (3) (see all 20)
hydroxamate	65.7	4	7737183 (2), 16242329 (1), 7577999 (1)
batimastat	58.9	3	9873491 (1), 11278347 (1)
(4-aminophenyl)mercuric acetate	55	4	10225852 (1)
goldthioglucose	50.2	2	9294486 (1), 2171513 (1)
actinonin	47.3	1	8076835 (1)
tetracycline	40.4	4	9437511 (2), 1425210 (1), 7923879 (1)
zinc	39.8	9	16242329 (2), 19173605 (2), 9461346 (1), 12213468 (1) (see all 5)
phosphonate	31.3	4	12363219 (2), 15725496 (1), 10978185 (1)

Search CenterWatch for drugs/clinical trials and news about MMP8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP8 gene:

NM_002424.2

Unigene Cluster for MMP8:

Matrix metallopeptidase 8 (neutrophil collagenase)

Hs.161839 [show with all ESTs]

Unigene Representative Sequence: NM_002424

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000236826(uc010rut.1 uc001phe.2 uc010ruu.1) ENST00000528662

ENST00000438475 ENST00000533258 ENST00000531168 ENST00000532799

miRNA Products:		OriGene 3'-UTR Clone: MMP8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP8
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP8:
		hsa-miR-502-5p hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-500a
		SwitchGear 3'UTR luciferase reporter plasmid: MMP8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP8 (see all 7) OriGene shRNA RFP: MMP8 OriGene siRNA: MMP8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP8 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP8 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP8 (NM_002424)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP8

Additional cDNA sequence:

AK292659.1 AK303388.1 AK303511.1 AK313374.1 BC074988.2 BC074989.2 BC144094.1 J05556.1

3 DOTS entries:

DT.40115414 DT.86854348 DT.95167581

24/30 AceView cDNA sequences (see all 30):

BC074988 BC074989 AL597614 AL597627 AL597567 J05556 AL601623 AL597547

BF977493 AL597474 NM_002424 AL597579 AL601742 BG218770 BG213446 BF905835

BI020191 AL597611 AL597490 AL597668 BX496138 AL121045 AL597300 AL597543

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MMP8 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13
SP1:					-		-		-
SP2:					-				-
SP3:					-
SP4:

ECgene alternative splicing isoforms for MMP8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTACTAGA

About this image
See MMP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP8

SOURCE GeneReport for Unigene cluster: Hs.161839

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894

Tissue specificity: Neutrophils

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP8:

Osteogenesis in human mouse rat

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP8 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP8

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP8 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP1⁶ Q5ZMQ8_CHICK⁶	matrix metalloproteinase 7	55(a) 49(a)	1 ↔ many possible ortholog	1(186797475-186803932) 1(186865326-186869665)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	53(a) 44(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	3(192130497-192142327) 3(192236788-192239847)
zebrafish (Danio rerio)	Actinopterygii	mmp13a⁶ mmp16a⁶	matrix metallopeptidase 16a (membrane-inserted)	44(a) 20(a)	1 ↔ many possible ortholog	10(39959934-39979810) 24(32795678-32875906)
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	39(a)		V(2905685-2909407) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT1G59970⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	26(a) 25(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 1(22073534-22074876)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	8(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 2(30974996-30977090)

ENSEMBL Gene Tree for MMP8 (if available)
TreeFam Gene Tree for MMP8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MMP8 gene

MMP13² MMP20² MMP14² MMP9² MMP16² MMP2² MMP25² MMP24²

MMP15² MMP11² MMP3² MMP27² MMP17² MMP10² MMP1²

18 SIMAP similar genes for MMP8 using alignment to 5 protein entries: MMP8_HUMAN (see all proteins):

MMP1 MMP13 MMP3 MMP27 MMP12 MMP7

MMP10 MMP20 MMP26 MMP2 MMP16 MMP14

MMP24 MMP15 mmp20 MMP17 MMP11 MMP25

MMP8 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MMP8
PGOHUM00000262186

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34322573^1,2	C,	--	98509563(-)	`AATCCC/-ACAGA`	1	--	ut3¹		5	NS	184
rs114911002^1,2	C,F,	--	98509981(+)	`GGCTGC/TTGTCC`	1	--	ut3¹		1	WA	118
rs34097194^1,2	C,F,	--	98510249(-)	`CACCAG/ATAGAA`	1	--	ut3¹		7	NS CSA WA	310
rs35800658^1,2	C,F,	--	98510477(-)	`TCTAAC/ACCCAG`	1	--	ut3¹		12	NS NA WA CSA	437
rs34349713^1,2	C,	--	98510795(-)	`TCAAAG/AAGAAG`	1	--	ut3¹		5	NS	188
rs35189111^1,2	C,F,	--	98510871(-)	`AATATG/ATTTGG`	1	--	ut3¹		7	NS NA	310
rs4369371^1,2	C	--	98512419(+)	`AATACG/TACTTT`	1	--	int¹		3	NA EA	350
rs28662184^1,2	C,F,	--	98513414(+)	`TCCCAG/CTAAAT`	1	--	int¹		13	NA NS CSA WA	374
rs80310808^1,2		--	98513591(+)	`GGTGCT/CTTGGT`	1	--	int¹		1	WA	118
rs112116517^1,2		--	98513610(+)	`TATGGG/AGTTCC`	1	--	int¹		2	CSA WA	120

HapMap Linkage Disequilibrium report for MMP8 (102582526 - 102597781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MMP8
3 CNVs: 85981 75785 85979
Human Gene Mutation Database (HGMD): MMP8

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP8 for disorders           About GeneDecksing

OMIM gene information: 120355    OMIM disorders: --

20/96 diseases for MMP8 (see all 96):    About MalaCards

arthritis hyper-ige syndrome periapical granuloma encephalomyelitis

dental caries aortic aneurysm amaurosis fugax refractive error

thoracic aortic aneurysm bronchiolitis obliterans abdominal aortic aneurysm oral submucous fibrosis

vernal keratoconjunctivitis blepharoconjunctivitis bacterial vaginosis type 2 diabetes mellitus

coronary heart disease pulmonary emphysema carotid artery disease cerebral palsy

6 diseases from the University of Copenhagen DISEASES database for MMP8:

Periodontitis Gingivitis Funisitis Carcinoma

Oropharynx cancer Arthritis

10/66 Novoseek disease relationships for MMP8 gene (see all 66) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chronic periodontitis	69.5	12	17122880 (2), 18360660 (2), 17076603 (2), 15025222 (2) (see all 6)
periodontal diseases	67.9	37	19751716 (4), 9021326 (3), 19040578 (3), 16570465 (3) (see all 15)
gingivitis	61.7	15	18403884 (4), 12828663 (2), 10225890 (1), 15817630 (1) (see all 8)
gingival pocket	51.8	1	16953818 (1)
gingival bleeding	51.5	1	11005153 (1)
periodontitis juvenile	49.5	1	8265204 (1)
periapical granuloma	48.4	3	12453017 (2), 11400151 (1)
chorioamnionitis	48.2	5	14711859 (4)
inflammation	47.4	35	12453017 (3), 11400151 (2), 16081833 (2), 17000236 (2) (see all 22)
tongue carcinoma	43.5	3	18253113 (1)

Genetic Association Database (GAD): MMP8
Human Genome Epidemiology (HuGE) Navigator: MMP8 (29 documents)

Export disorders for MMP8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP8 gene, integrated from 9 sources (see all 546):
(articles sorted by number of sources associating them with MMP8)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase. (PubMed id 2176876)^{1, 2, 9} Mallya S.K.... van Wart H.E. (1990)
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). (PubMed id 15367487)^{1, 4, 9} Wang H....Strauss J.F. (2004)
The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. (PubMed id 8137810)^{1, 2, 9} Bode W.... Tschesche H. (1994)
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. (PubMed id 2164002)^{1, 2, 9} Hasty K.A.... Mainardi C.L. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. (PubMed id 12101112)^{1, 4} Chiu C.J....Chen C.J. (2002)
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data. (PubMed id 9655333)^{1, 2} Brandstetter H.... Grams F. (1998)
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile. (PubMed id 9249047)^{1, 2} Betz M.... Gomis-Rueth F.-X. (1997)
Structure of human neutrophil collagenase reveals large S1' specificity pocket. (PubMed id 7656015)^{1, 2} Stams T.... Rubin B. (1994)
Structural implications for the role of the N-terminus in the 'superactivation' of collagenases. A crystallographic study. (PubMed id 8307185)^{1, 2} Reinemer P.... Bode W. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4317	HGNC: 7175	AceView: MMP8	Ensembl:ENSG00000118113	euGenes: HUgn4317
ECgene: MMP8	H-InvDB: MMP8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP8	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp8/

Intellectual Property for MMP8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP8 gene:
Search GeneIP for patents involving MMP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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matrix metallopeptidase 8 (neutrophil collagenase)

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preterm delivery
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MMP8 Gene

matrix metallopeptidase 8 (neutrophil collagenase)

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