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MMP8 Gene

protein-coding   GIFtS: 73
GCID: GC11M102617

Matrix Metallopeptidase 8 (Neutrophil Collagenase)

(Previous name: matrix metalloproteinase 8 (neutrophil collagenase))
(Previous symbol: CLG1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 8 (Neutrophil Collagenase)1 2     PMNL Collagenase2 3
CLG11 2 3 5     HNC2
Matrix Metalloproteinase 8 (Neutrophil Collagenase)1 2     Neutrophil Collagenase2
Matrix Metalloproteinase-82 3     EC 3.4.24.343
MMP-82 3     EC 3.4.248
PMNL-CL2 3     

External Ids:    HGNC: 71751   Entrez Gene: 43172   Ensembl: ENSG000001181137   OMIM: 1203555   UniProtKB: P228943   

Export aliases for MMP8 gene to outside databases

Previous GC identifers: GC11M104777 GC11M103940 GC11M102121 GC11M102088 GC11M098509


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP8 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in
secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type
I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MMP8 Gene:
MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)) is a protein-coding gene. Diseases associated with MMP8 include periodontal disease, and funisitis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894
Function: Can degrade fibrillar type I, II, and III collagens

summary for MMP8 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP8 gene promoter:
         SRF   SRF (504 AA)   p300   MEF-2A   PPAR-gamma1   c-Rel   FOXO4   aMEF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP8 promoter sequence
   Search Chromatin IP Primers for MMP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q21-q22

MMP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102617:  view genomic region     (about GC identifiers)

Start:
102,582,526 bp from pter      End:
102,597,781 bp from pter
Size:
15,256 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894 (See protein sequence)
Recommended Name: Neutrophil collagenase precursor  
Size: 467 amino acids; 53412 Da
Cofactor: Binds 3 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Selected PDB 3D structures from and Proteopedia for MMP8 (see all 23):
1A85 (3D)        1A86 (3D)        1BZS (3D)        1I73 (3D)        1I76 (3D)        1JAN (3D)    
Secondary accessions: Q45F99

Explore the universe of human proteins at neXtProt for MMP8: NX_P22894

Explore proteomics data for MMP8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn73, Asn112, Asn204, Asn246
  • Selected DME Specific Peptides for MMP8 (P22894) (see all 6)
     LTFDAIT  DNSPFDG  PRCGVPD  VAAHEFGH 


    See MMP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002415.1  
    ENSEMBL proteins: 
     ENSP00000236826   ENSP00000431431   ENSP00000401004   ENSP00000437173   ENSP00000433812  
     ENSP00000431938  
    Reactome Protein details: P22894

    MMP8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP8 (MMP-8)
    Enzo Life Sciences proteins for MMP8
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MMP8
    GenScript Custom Purified and Recombinant Proteins Services for MMP8
    Novus Biologicals MMP8 Proteins
    Novus Biologicals MMP8 Lysate
    Sino Biological Recombinant Protein for MMP8
    Sino Biological Cell Lysate for MMP8
    ProSpec Recombinant Protein for MMP8
    Cloud-Clone Corp. Proteins for MMP8

    MMP8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP8
    R&D Systems Antibodies for MMP8 (MMP-8)
    OriGene Antibodies for MMP8
    OriGene Custom Antibody Services for MMP8
    Novus Biologicals MMP8 Antibodies
    Abcam antibodies for MMP8
    Cloud-Clone Corp. Antibodies for MMP8
    ThermoFisher Antibody for MMP8
    LSBio Antibodies in human, mouse, rat for MMP8

    MMP8 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MMP8
    OriGene Custom Assay Services for MMP8
    R&D Systems ELISAs for MMP8 (MMP-8)         (see all)
    GenScript MMP8-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP8
    Cloud-Clone Corp. ELISAs for MMP8
    Cloud-Clone Corp. CLIAs for MMP8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP8
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR028709 MMP1/MMP8

    Graphical View of Domain Structure for InterPro Entry P22894

    ProtoNet protein and cluster: P22894

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP8_HUMAN, P22894
    Function: Can degrade fibrillar type I, II, and III collagens
    Catalytic activity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this
    enzyme cleaves type III collagen more slowly than type I
    Enzyme regulation: Cannot be activated without removal of the activation peptide

         Genatlas biochemistry entry for MMP8:
    matrix metalloproteinase 8,regulator in matrix remodeling,MMP cluster

         Enzyme Numbers (IUBMB): EC 3.4.242 EC 3.4.24.341

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004252serine-type endopeptidase activity IDA16192646
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding TAS2164002
         
    MMP8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MMP8:
     Decreased Salmonella enterica  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp8):
     immune system  tumorigenesis 

    MMP8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp8tm1Lotn for MMP8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP8

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP8:
    hsa-mir-26b-5p (MIRT028875)

    Block miRNA regulation of human, mouse, rat MMP8 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MMP8:
    hsa-miR-502-5p hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidMMP8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP8
    Predesigned siRNA for gene silencing in human, mouse, rat MMP8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP8

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP8 (see all 8)
    OriGene ORF clones in mouse, rat for MMP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP8 (NM_002424)
    Sino Biological Human cDNA Clone for MMP8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP8
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP8_HUMAN, P22894: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix (Probable).
    Note=Stored in intracellular granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    nucleus2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA2164002
    GO:0031012extracellular matrix ----

    MMP8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP8 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    3Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    5Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP8
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP8
        Matrix Metalloproteinases


    3 Reactome Pathways for MMP8
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases



    MMP8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP8: 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for MMP8 (P228943 ENSP000002368264) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL2P135003, ENSP000002258314I2D: score=1 STRING: ENSP00000225831
    UMODP079113, ENSP000003062794I2D: score=1 STRING: ENSP00000306279
    TFPIP106463, ENSP000002331564I2D: score=1 STRING: ENSP00000233156
    TIMP2P160353, ENSP000002627684I2D: score=1 STRING: ENSP00000262768
    BCANQ96GW73, ENSP000003312104I2D: score=2 STRING: ENSP00000331210
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA2164002
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    MMP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP8
    Selected ApexBio Compounds for MMP8 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for MMP8 (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Hydroxyamine-2-Isobutylmalonic Acid-- --target--17139284 17016423 10592235
    2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione-- --target--17139284 17016423 10592235
    2-Thiomethyl-3-Phenylpropanoic Acid-- --target--17139284 17016423 10592235
    Batimastat-- 130370-60-4target--17139284 17016423 10592235
    Glycinamid-- --target--17139284 17016423
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951
    (1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID-- --target--10592235
    (1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID-- --target--10592235
    (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MMP8 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phenylmercuric chloride 73.3 1 2171513 (1)
    doxycycline 68.4 54 16411105 (6), 10366106 (4), 17122880 (3), 9395486 (3) (see all 20)
    hydroxamate 65.7 4 7737183 (2), 16242329 (1), 7577999 (1)
    batimastat 58.9 3 9873491 (1), 11278347 (1)
    (4-aminophenyl)mercuric acetate 55 4 10225852 (1)
    goldthioglucose 50.2 2 9294486 (1), 2171513 (1)
    actinonin 47.3 1 8076835 (1)
    tetracycline 40.4 4 9437511 (2), 1425210 (1), 7923879 (1)
    zinc 39.8 9 16242329 (2), 19173605 (2), 9461346 (1), 12213468 (1) (see all 5)
    phosphonate 31.3 4 12363219 (2), 15725496 (1), 10978185 (1)



    MMP8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP8 gene: 
    NM_002424.2  

    Unigene Cluster for MMP8:

    Matrix metallopeptidase 8 (neutrophil collagenase)
    Hs.161839  [show with all ESTs]
    Unigene Representative Sequence: NM_002424
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236826(uc010rut.1 uc001phe.2 uc010ruu.1) ENST00000528662
    ENST00000438475 ENST00000533258 ENST00000531168 ENST00000532799
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MMP8 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MMP8:
    hsa-miR-502-5p hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidMMP8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MMP8
    Predesigned siRNA for gene silencing in human, mouse, rat MMP8
    Clone
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    OriGene clones in human, mouse for MMP8 (see all 8)
    OriGene ORF clones in mouse, rat for MMP8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP8 (NM_002424)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MMP8
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP8
      QuantiTect SYBR Green Assays in human, mouse, rat MMP8
      QuantiFast Probe-based Assays in human, mouse, rat MMP8

    Additional mRNA sequence: 

    AK292659.1 AK303388.1 AK303511.1 AK313374.1 BC074988.2 BC074989.2 BC144094.1 J05556.1 

    3 DOTS entries:

    DT.40115414  DT.86854348  DT.95167581 

    Selected AceView cDNA sequences (see all 30):

    BC074989 BC074988 AL597614 BF977493 AL597627 BX496138 AL597579 AL597611 
    J05556 AL597547 AL597474 BI020191 AL601623 BG218770 AL597668 BG213446 
    NM_002424 AL121045 AL601742 AL597567 AL597490 BF905835 AL597300 AL597543 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MMP8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -     -     -                                                                           
    SP2:              -           -                                                                           
    SP3:              -                                                                                       
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for MMP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTACTAGA
    MMP8 Expression
    About this image


    MMP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
    MMP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.161839

    UniProtKB/Swiss-Prot: MMP8_HUMAN, P22894
    Tissue specificity: Neutrophils

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP8: 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp81 , 5 matrix metallopeptidase 81, 5 80.01(n)1
    74.24(a)1
      9 (2.46 cM)5
    173941  NM_008611.41  NP_032637.31 
     75584295 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    55(a)
    1 → many
    1(181709981-181716472)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    1 → many
    3(192130497-192142327)
    zebrafish
    (Danio rerio)
    Actinopterygii mmp13a1 matrix metalloproteinase 13a 57.16(n)
    48.42(a)
      387293  XM_005169199.1  XP_005169256.1 


    ENSEMBL Gene Tree for MMP8 (if available)
    TreeFam Gene Tree for MMP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP8 gene
    MMP202  MMP132  MMP142  MMP252  MMP162  MMP72  MMP242  MMP152  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    16 SIMAP similar genes for MMP8 using alignment to 5 protein entries:     MMP8_HUMAN (see all proteins):
    MMP1    MMP13    MMP3    MMP27    MMP12    MMP7
    MMP10    MMP20    MMP26    MMP2    MMP16    MMP14
    MMP24    MMP15    mmp20    MMP17

    MMP8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MMP8
    PGOHUM00000262186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP8 (see all 537)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112253931,2
    A--98515782(+) cccccA/Caaaaa 1 -- int1 trp30--------
    rs50116351,2
    C--98519868(+) TTGCTG/AGTAGT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1476363811,2
    --102451770(+) ACGTTA/GATATG 1 -- ds50010--------
    rs1423142241,2
    --102451844(+) GGTAGA/GTAGTT 1 -- ds50010--------
    rs1501381761,2
    C--102451934(+) AATAAC/TGTATT 1 -- ds50010--------
    rs1385656991,2
    C--102452023(+) ATTATA/CAATAT 1 -- ds50010--------
    rs1488779551,2
    C--102452081(+) TTTGCA/TATTCC 1 -- ds50010--------
    rs1436940611,2
    C--102452083(+) TGCTAA/TTCCTT 1 -- ds50010--------
    rs343225731,2
    C--102452241(-) AATCCC/-ACAGA 1 -- ut315Minor allele frequency- -:0.01NS 184
    rs1383337121,2
    --102452337(+) ATTATA/GTTCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP8 (102582526 - 102597781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832252CNV Gain17160897

    Human Gene Mutation Database (HGMD): MMP8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP8
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120355    OMIM disorders: --

    Selected diseases for MMP8 (see all 91):    
    About MalaCards
    periodontal disease    funisitis    blepharoconjunctivitis    amaurosis fugax
    chorioamnionitis    preterm premature rupture of the membranes    dental caries    malignant ovarian cyst
    tendinopathy    rosacea    intrauterine infections    bronchiolitis obliterans
    periapical granuloma    ovarian cyst    bronchiectasis    periodontitis
    gingivitis    carotid artery disease    arthritis    encephalomyelitis

    6 diseases from the University of Copenhagen DISEASES database for MMP8:
    Periodontitis     Funisitis     Gingivitis     Carcinoma
    Oropharynx cancer     Arthritis

    MMP8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for MMP8 gene (see all 66)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic periodontitis 69.5 12 17122880 (2), 18360660 (2), 17076603 (2), 15025222 (2) (see all 6)
    periodontal diseases 67.9 37 19751716 (4), 9021326 (3), 19040578 (3), 16570465 (3) (see all 15)
    gingivitis 61.7 15 18403884 (4), 12828663 (2), 10225890 (1), 15817630 (1) (see all 8)
    gingival pocket 51.8 1 16953818 (1)
    gingival bleeding 51.5 1 11005153 (1)
    periodontitis juvenile 49.5 1 8265204 (1)
    periapical granuloma 48.4 3 12453017 (2), 11400151 (1)
    chorioamnionitis 48.2 5 14711859 (4)
    inflammation 47.4 35 12453017 (3), 11400151 (2), 16081833 (2), 17000236 (2) (see all 22)
    tongue carcinoma 43.5 3 18253113 (1)

    Genetic Association Database (GAD): MMP8
    Human Genome Epidemiology (HuGE) Navigator: MMP8 (29 documents)

    Export disorders for MMP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP8 gene, integrated from 10 sources (see all 558):
    (articles sorted by number of sources associating them with MMP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase. (PubMed id 2176876)1, 2, 9 Mallya S.K.... van Wart H.E. (Biochemistry 1990)
    2. Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. (PubMed id 19094243)1, 4, 9 GonzA!lez-Arriaga P....TardA^n A. (BMC Cancer 2008)
    3. Lack of association between matrix metalloproteinase 8 promoter polymorphism and bronchiectasis in Koreans. (PubMed id 17728507)1, 4, 9 Lee J....Yim J.J. (J. Korean Med. Sci. 2007)
    4. Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. (PubMed id 17974962)1, 4, 9 Decock J....Ye S. (Cancer Res. 2007)
    5. Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). (PubMed id 15367487)1, 4, 9 Wang H....Strauss J.F. (Hum. Mol. Genet. 2004)
    6. Matrix metalloproteinase polymorphisms and bladder cancer risk. (PubMed id 17178858)1, 4, 9 Kader A.K....Wu X. (Cancer Res. 2006)
    7. No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. (PubMed id 18768525)1, 4, 9 Qiu W....He F. (amp 2008)
    8. The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. (PubMed id 8137810)1, 2, 9 Bode W.... Tschesche H. (EMBO J. 1994)
    9. Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. (PubMed id 2164002)1, 2, 9 Hasty K.A.... Mainardi C.L. (J. Biol. Chem. 1990)
    10. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4317 HGNC: 7175 AceView: MMP8 Ensembl:ENSG00000118113 euGenes: HUgn4317
    ECgene: MMP8 H-InvDB: MMP8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP8 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP8 gene:
    Search GeneIP for patents involving MMP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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