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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP7 Gene

protein-coding   GIFtS: 74
GCID: GC11M102425

Matrix Metallopeptidase 7 (Matrilysin, Uterine)

(Previous names: matrix metalloproteinase 7 (matrilysin, uterine))
(Previous symbol: MPSL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 7 (Matrilysin, Uterine)1 2     matrilysin2
MPSL11 2 3     matrin2
Matrix Metalloproteinase 7 (Matrilysin, Uterine)1 2     Uterine Matrilysin2
Matrix Metalloproteinase-72 3     EC 3.4.24.233
Pump-1 Protease2 3     Matrin3
Uterine Metalloproteinase2 3     PUMP13
MMP-72 3     EC 3.4.248
PUMP-12     

External Ids:    HGNC: 71741   Entrez Gene: 43162   Ensembl: ENSG000001376737   OMIM: 1789905   UniProtKB: P092373   

Export aliases for MMP7 gene to outside databases

Previous GC identifers: GC11M104584 GC11M103748 GC11M101928 GC11M101896 GC11M098318


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP7 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans,
fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal
protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the
activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to
chromosome 11q22.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP7 Gene: 
MMP7 (matrix metallopeptidase 7 (matrilysin, uterine)) is a protein-coding gene. Diseases associated with MMP7 include rectosigmoid cancer, and focal myositis, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and Metalloproteases in connective tissue degradation. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237
Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

summary for MMP7 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP7 gene promoter:
         STAT1   p53   AP-1   ATF-2   STAT5A   Tal-1beta   c-Jun   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q21-q22

MMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102425:  view genomic region     (about GC identifiers)

Start:
102,391,239 bp from pter      End:
102,401,484 bp from pter
Size:
10,246 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237 (See protein sequence)
Recommended Name: Matrilysin precursor  
Size: 267 amino acids; 29677 Da
Cofactor: Binds 2 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)
6 PDB 3D structures from and Proteopedia for MMP7:
1MMP (3D)        1MMQ (3D)        1MMR (3D)        2DDY (3D)        2Y6C (3D)        2Y6D (3D)    
Secondary accessions: Q9BTK9

Explore the universe of human proteins at neXtProt for MMP7: NX_P09237

Explore proteomics data for MMP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09237

  • 3 DME Specific Peptides for MMP7 (P09237)
     PRCGVPD  MQKFFGL  LAHAFAPG 

    MMP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MMP7 Protein Expression
    REFSEQ proteins: NP_002414.1  
    ENSEMBL proteins: 
     ENSP00000260227  
    Reactome Protein details: P09237
    Human Recombinant Protein Products for MMP7: 
    EMD Millipore Purified and/or Recombinant MMP7 Protein
    R&D Systems Recombinant & Natural Proteins for MMP7 (MMP-7)
    Enzo Life Sciences proteins for MMP7
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MMP7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MMP7
    GenScript Custom Purified and Recombinant Proteins Services for MMP7
    Novus Biologicals MMP7 Proteins
    Novus Biologicals MMP7 Lysates
    Sino Biological Recombinant Protein for MMP7
    Sino Biological Cell Lysate for MMP7 
    ProSpec Recombinant Protein for MMP7
    Cloud-Clone Corp. Proteins for MMP7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS1497627
    GO:0031012extracellular matrix ----

    MMP7 for ontologies           About GeneDecksing



    MMP7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP7
    R&D Systems Antibodies for MMP7 (MMP-7)
    Cell Signaling Technology (CST) Antibodies for MMP7 
    OriGene Antibodies for MMP7
    OriGene Custom Antibody Services for MMP7
    GenScript Custom Superior Antibodies Services for MMP7
    Novus Biologicals MMP7 Antibodies
    Abcam antibodies for MMP7
    Cloud-Clone Corp. Antibodies for MMP7 
    ThermoFisher Antibody for MMP7
    LSBio Antibodies in human, mouse, rat for MMP7 

    Assay Products for MMP7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP7
    R&D Systems ELISAs for MMP7 (MMP-7)         (see all)
    GenScript MMP7-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for MMP7
    Cloud-Clone Corp. ELISAs for MMP7 
    Cloud-Clone Corp. CLIAs for MMP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP7 
    Cell-surface protein and extracellular matrix metalloproteinases

    5/6 InterPro protein domains (see all 6):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR006026 Peptidase_Metallo
     IPR001818 Pept_M10_metallopeptidase

    Graphical View of Domain Structure for InterPro Entry P09237

    ProtoNet protein and cluster: P09237

    1 Blocks protein domain: IPB002477 Putative peptidoglycan binding domain 1

    UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family


    MMP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP7_HUMAN, P09237
    Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase
    Catalytic activity: Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen
    types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)

         Genatlas biochemistry entry for MMP7:
    matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass
    of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating
    angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta
    catenin/CF4 and important factor in early tumor growth progression and metastasis

         Enzyme Numbers (IUBMB): EC 3.4.24.231 EC 3.4.242

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP7 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp7):
     cardiovascular system  cellular  digestive/alimentary  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  tumorigenesis  vision/eye 

    MMP7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp7tm1Lmm for MMP7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MMP7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MMP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP7
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP7:
    hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidMMP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MMP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP7
    Sirion Biotech Customized adenovirus for overexpression of MMP7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MMP7 (see all 8)
    OriGene ORF clones in mouse, rat for MMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
    Sino Biological Human cDNA Clone for MMP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7
    Sirion Biotech Customized lentivirus for stable overexpression of MMP7 
                         Customized lentivirus expression plasmids for stable overexpression of MMP7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP7
    Search LifeMap BioReagents cell lines for MMP7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MMP7 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    Metalloproteases in connective tissue degradation0.31
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    Degradation of collagen0.79
    4Collagen biosynthesis and modifying enzymes
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    5Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MMP7
        Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP7 (see all 6)
        Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    WNT Signaling

    2 Cell Signaling Technology (CST) Pathways for MMP7
        Angiogenesis
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for MMP7
        Cell adhesion ECM remodeling

    5/6 BioSystems Pathways for MMP7 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Matrix Metalloproteinases
    AGE/RAGE pathway
    Alpha6-Beta4 Integrin Signaling Pathway
    p75(NTR)-mediated signaling


    5/6        Reactome Pathways for MMP7 (see all 6)
        Extracellular matrix organization
    Assembly of collagen fibrils and other multimeric structures
    Degradation of the extracellular matrix
    Collagen formation
    Degradation of collagen


    1         Kegg Pathway  (Kegg details for MMP7):
        Wnt signaling pathway


    MMP7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for MMP7 (P092372, 3 ENSP000002602274) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    SERPINA1P010093, ENSP000003480684I2D: score=2 STRING: ENSP00000348068
    SPP1P104513, ENSP000003785174I2D: score=2 STRING: ENSP00000378517
    DCNP075853, ENSP000000527544I2D: score=1 STRING: ENSP00000052754
    DEFA1P596653I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002779antibacterial peptide secretion IEA--
    GO:0006508proteolysis IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    MMP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMP7 for compounds           About GeneDecksing

    EMD Millipore small molecules for MMP7:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MMP7

    Compounds for MMP7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for MMP7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetantagonist10852638 10669951
    (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE-- --target--10592235
    5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID-- --target--10592235
    N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE-- --target--10592235

    10/33 Novoseek inferred chemical compound relationships for MMP7 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 69.9 6 11481258 (1), 7896811 (1)
    marimastat 56 5 14632921 (2), 16595036 (2)
    matrigel 52.5 1 14606648 (1)
    auraptene 50.7 3 16979634 (2), 17151446 (1)
    vegf 46.5 51 18974372 (4), 15183452 (2), 17115023 (2), 19031137 (2) (see all 22)
    hocl 25.3 8 12759346 (4), 11533038 (2), 14670964 (1)
    egcg 24.5 7 17928719 (2), 15860507 (1), 17981559 (1)
    glyceraldehyde 3-phosphate 18.7 4 8949652 (1), 11757034 (1), 17649785 (1), 16101153 (1)
    oligonucleotide 16.3 2 16697739 (1), 9550265 (1)
    ag 1478 14.8 2 16311341 (2)

    Search CenterWatch for drugs/clinical trials and news about MMP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MMP7 gene: 
    NM_002423.3  

    Unigene Cluster for MMP7:

    Matrix metallopeptidase 7 (matrilysin, uterine)
    Hs.2256  [show with all ESTs]
    Unigene Representative Sequence: BQ688566
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260227(uc001phb.3) ENST00000533366(uc009yxd.3) ENST00000531200(uc010rus.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP7
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP7:
    hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidMMP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MMP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP7
    Clone
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    OriGene clones in human, mouse for MMP7 (see all 8)
    OriGene ORF clones in mouse, rat for MMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7
    Sirion Biotech Customized lentivirus for stable overexpression of MMP7 
                         Customized lentivirus expression plasmids for stable overexpression of MMP7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MMP7
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP7

    Additional mRNA sequence: 

    AK222980.1 AK293359.1 AK309687.1 BC003635.2 DQ399600.1 X07819.1 Z11887.1 

    4 DOTS entries:

    DT.446734  DT.95270459  DT.100022951  DT.95270460 

    24/89 AceView cDNA sequences (see all 89):

    BM983702 AA344350 BI764547 BM983722 AI888609 AI888421 AU155489 AI095584 
    AI675414 BQ690859 CB111200 AA031513 BU686947 AA975518 AA970839 AI871918 
    BC003635 BG741319 BU589659 W60256 AW469327 BF513409 AA299556 AI377209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP7 expression in normal human tissues (normalized intensities)      MMP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAATTTAA
    MMP7 Expression
    About this image


    MMP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             Human Renal Epithelial Cells (HREpiC)   
             breast epithelium   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Human Renal Mesangial Cells (HRMC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells

    See MMP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP7

    SOURCE GeneReport for Unigene cluster: Hs.2256
        SABiosciences Expression via Pathway-Focused PCR Arrays including MMP7 (see all 8): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP7 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp71 , 5 matrix metallopeptidase 71, 5 74.55(n)1
    70.61(a)1
      9 (2.46 cM)5
    173931  NM_010810.41  NP_034940.21 
     76920905 
    chicken
    (Gallus gallus)
    Aves MMP71 matrix metallopeptidase 7 (matrilysin, uterine) 59.62(n)
    53.46(a)
      418983  NM_001006278.1  NP_001006278.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    48(a)
    46(a)
    1 ↔ many
    1 ↔ many
    3(192251865-192260286)
    3(192236501-192241705)
    zebrafish
    (Danio rerio)
    Actinopterygii MMP76
    matrix metallopeptidase 7 (matrilysin, uterine)
    42(a)
    1 ↔ 1
    10(39940332-39943304)
    worm
    (Caenorhabditis elegans)
    Secernentea T21D11.16
    H36L18.16
    Protein H36L18.1
    21(a)
    17(a)
    many ↔ many
    many ↔ many
    III(7245482-7247784)
    X(12647117-12651487)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G166401 matrix metalloprotease domain-containing protein 49.71(n)
    43.91(a)
      827365  NM_117765.3  NP_193397.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05579001 hypothetical protein 45.71(n)
    40.51(a)
      4349359  NM_001071893.2  NP_001065361.2 


    ENSEMBL Gene Tree for MMP7 (if available)
    TreeFam Gene Tree for MMP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP7 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP242  MMP152  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    18 SIMAP similar genes for MMP7 using alignment to 2 protein entries:     MMP7_HUMAN (see all proteins):
    MMP2    MMP20    MMP1    MMP12    MMP17    MMP13
    MMP8    MMP26    MMP27    MMP3    MMP10    MMP11
    MMP14    MMP24    MMP25    MMP16    MMP19    mmp20

    MMP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/358 SNPs in MMP7 are shown (see all 358)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886993871,2
    --102390840(+) TCTGCA/GTTGGC 1 -- int10--------
    rs1435951291,2
    --102390857(+) AAAAGA/GGAAGG 1 -- int10--------
    rs1925378221,2
    --102390994(+) TTGTGA/GGAAGA 1 -- int10--------
    rs178849401,2
    C,F--102391033(-) GGCCCA/C/GTGCTC 1 -- int11NS 180
    rs1840726031,2
    --102391034(+) AGCACA/GGGCCA 1 -- int10--------
    rs178825051,2
    C,F--102391036(-) TGTGGC/TCCGTG 1 -- int11Minor allele frequency- T:0.01NS 178
    rs178845961,2
    C,F--102391163(-) AATCCC/TACCAC 1 -- int12Minor allele frequency- T:0.02NS WA 272
    rs1911893941,2
    --102391172(+) TTCTTC/TTTTTG 1 -- int10--------
    rs1837891921,2
    --102391204(+) TATAGC/TATGTC 1 -- int10--------
    rs770305791,2
    C--102391273(+) TATTTG/ATGTAT 1 -- ut312Minor allele frequency- A:0.15WA 120

    HapMap Linkage Disequilibrium report for MMP7 (102391239 - 102401484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MMP7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469990CNV Gain18288195
    nsv468854CNV Gain19166990


    Human Gene Mutation Database (HGMD): MMP7
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 178990    OMIM disorders: --

    20/119 diseases for MMP7 (see all 119):    About MalaCards
    rectosigmoid cancer    focal myositis    encephalomyelitis    biliary atresia
    ovarian mucinous neoplasm    pediatric multiple sclerosis    thymic epithelial tumor    h. pylori infection
    carotid artery disease    uterine carcinosarcoma    adenomyosis    refractive error
    hepatocellular adenoma    desmoid tumor    pulmonary fibrosis    mixed cryoglobulinemia
    cutaneous lupus erythematosus    dermatitis herpetiformis    cryoglobulinemia    renal dysplasia

    2 diseases from the University of Copenhagen DISEASES database for MMP7:
    Carcinoma     Colorectal cancer

    MMP7 for disorders           About GeneDecksing

    10/93 Novoseek inferred disease relationships for MMP7 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 68.1 187 15966224 (6), 15142461 (5), 15143943 (5), 16536985 (5) (see all 82)
    colon cancer 63.6 46 19728912 (7), 11781281 (3), 15138601 (2), 19002110 (2) (see all 19)
    tumors 61.1 306 10713661 (7), 19956372 (5), 11832095 (4), 11212252 (4) (see all 99)
    colorectal cancer 58.4 53 15966224 (3), 18636198 (3), 11832095 (2), 11801551 (2) (see all 30)
    cancer 56.7 138 17145820 (5), 15623600 (4), 15865605 (4), 15175941 (3) (see all 74)
    carcinoma 52.2 80 10502722 (7), 11900228 (4), 9583735 (4), 17507610 (4) (see all 38)
    colon carcinoma 49.8 8 9220495 (3), 11217438 (1), 14647460 (1), 9626346 (1) (see all 5)
    colorectal carcinoma 49.6 26 16474169 (2), 17649785 (2), 7889484 (2), 11355941 (2) (see all 14)
    aggressiveness 48.1 7 11900228 (1), 8949652 (1), 7889484 (1), 14691910 (1)
    adenoma 47.3 29 17009118 (4), 15800927 (2), 15634446 (2), 18500535 (2) (see all 17)

    Genetic Association Database (GAD): MMP7
    Human Genome Epidemiology (HuGE) Navigator: MMP7 (52 documents)

    Export disorders for MMP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP7 gene, integrated from 9 sources (see all 814):
    (articles sorted by number of sources associating them with MMP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PubMed id 18648013)1, 4, 9 Beeghly-Fadiel A....Zheng W. (2008)
    2. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PubMed id 20113256)1, 4, 9 Yi Y.C....Yang S.F. (2010)
    3. Genetic polymorphisms in the MMP-7 gene and breast cancer survival. (PubMed id 18798254)1, 4, 9 Beeghly-Fadiel A....Zheng W. (2009)
    4. A novel nonsynonymous variant of matrix metalloprotei nase-7 confers risk of liver cirrhosis. (PubMed id 19676133)1, 4, 9 Hung T.M....Chang M.F. (2009)
    5. Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China. (PubMed id 16455621)1, 4, 9 Shan K....Yan L. (2006)
    6. SNPs in matrix metalloproteinase genes and lung cance r chemotherapy response and prognosis. (PubMed id 19643940)1, 4, 9 Scherf D.B....Risch A. (2009)
    7. Transforming growth factor-B1 and matrix metalloproteinase-7 promoter variants induce risk for Helicobacter pylori-associated gastric precancerous lesions. (PubMed id 19317620)1, 4, 9 Achyut B.R....Mittal B. (2009)
    8. Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population. (PubMed id 19132754)1, 4, 9 Jin G....Shen H. (2009)
    9. Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. (PubMed id 18958543)1, 4, 9 Sugimoto M....Hishida A. (2008)
    10. MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer. (PubMed id 18448157)1, 4, 9 Singh H....Mittal B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4316 HGNC: 7174 AceView: MMP7 Ensembl:ENSG00000137673 euGenes: HUgn4316
    ECgene: MMP7 Kegg: 4316 H-InvDB: MMP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MMP7 gene:
    Search GeneIP for patents involving MMP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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