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Aliases for MMP7 Gene

Aliases for MMP7 Gene

  • Matrix Metallopeptidase 7 2 3 5
  • Matrix Metalloproteinase 7 (Matrilysin, Uterine) 2 3
  • Matrix Metalloproteinase-7 3 4
  • Uterine Metalloproteinase 3 4
  • Pump-1 Protease 3 4
  • Matrilysin 2 3
  • Matrin 3 4
  • MPSL1 3 4
  • MMP-7 3 4
  • Matrix Metallopeptidase 7 (Matrilysin, Uterine) 3
  • Uterine Matrilysin 3
  • EC 3.4.24.23 4
  • EC 3.4.24 61
  • PUMP-1 3
  • PUMP1 4

External Ids for MMP7 Gene

Previous HGNC Symbols for MMP7 Gene

  • MPSL1

Previous GeneCards Identifiers for MMP7 Gene

  • GC11M104584
  • GC11M103748
  • GC11M101928
  • GC11M101896
  • GC11M098318

Summaries for MMP7 Gene

Entrez Gene Summary for MMP7 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP7 Gene

MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Brain Glioblastoma Multiforme and Coronary Artery Aneurysm. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Integrin Pathway. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP3.

UniProtKB/Swiss-Prot for MMP7 Gene

  • Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Tocris Summary for MMP7 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP7 Gene

Genomics for MMP7 Gene

Regulatory Elements for MMP7 Gene

Enhancers for MMP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MMP7 on UCSC Golden Path with GeneCards custom track

Promoters for MMP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP7 Gene

Chromosome:
11
Start:
102,520,508 bp from pter
End:
102,530,753 bp from pter
Size:
10,246 bases
Orientation:
Minus strand

Genomic View for MMP7 Gene

Genes around MMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP7 Gene

Proteins for MMP7 Gene

  • Protein details for MMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09237-MMP7_HUMAN
    Recommended name:
    Matrilysin
    Protein Accession:
    P09237
    Secondary Accessions:
    • Q9BTK9

    Protein attributes for MMP7 Gene

    Size:
    267 amino acids
    Molecular mass:
    29677 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP7 Gene

neXtProt entry for MMP7 Gene

Selected DME Specific Peptides for MMP7 Gene

Post-translational modifications for MMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP7 (MMP7)
  • Abcam antibodies for MMP7

Protein Products

  • Abcam proteins for MMP7

Domains & Families for MMP7 Gene

Gene Families for MMP7 Gene

Suggested Antigen Peptide Sequences for MMP7 Gene

Graphical View of Domain Structure for InterPro Entry

P09237

UniProtKB/Swiss-Prot:

MMP7_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP7: view

Function for MMP7 Gene

Molecular function for MMP7 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta catenin/CF4 and important factor in early tumor growth progression and metastasis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
UniProtKB/Swiss-Prot Function:
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP7 Gene

Gene Ontology (GO) - Molecular Function for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008201 heparin binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP7: view
genes like me logo Genes that share phenotypes with MMP7: view

Animal Models for MMP7 Gene

MGI Knock Outs for MMP7:

Animal Model Products

CRISPR Products

miRNA for MMP7 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP7

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP7 Gene

Localization for MMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP7 Gene COMPARTMENTS Subcellular localization image for MMP7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0009986 cell surface IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MMP7: view

Pathways & Interactions for MMP7 Gene

genes like me logo Genes that share pathways with MMP7: view

Gene Ontology (GO) - Biological Process for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007568 aging IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process TAS --
GO:0031667 response to nutrient levels IEA --
genes like me logo Genes that share ontologies with MMP7: view

No data available for SIGNOR curated interactions for MMP7 Gene

Drugs & Compounds for MMP7 Gene

(24) Drugs for MMP7 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE Experimental Pharma Target 0
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID Experimental Pharma Target 0
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE Experimental Pharma Target 0
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0

(21) Additional Compounds for MMP7 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP7 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9

(4) ApexBio Compounds for MMP7 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor 130370-60-4
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent 10592-13-9
Marimastat MMPs inhibitor,board spectrum 154039-60-8
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
genes like me logo Genes that share compounds with MMP7: view

Drug Products

Transcripts for MMP7 Gene

mRNA/cDNA for MMP7 Gene

Unigene Clusters for MMP7 Gene

Matrix metallopeptidase 7 (matrilysin, uterine):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP7 Gene

No ASD Table

Relevant External Links for MMP7 Gene

GeneLoc Exon Structure for
MMP7
ECgene alternative splicing isoforms for
MMP7

Expression for MMP7 Gene

mRNA expression in normal human tissues for MMP7 Gene

mRNA differential expression in normal tissues according to GTEx for MMP7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.0), Kidney - Cortex (x8.1), Pancreas (x5.7), and Breast - Mammary Tissue (x4.4).

Protein differential expression in normal tissues from HIPED for MMP7 Gene

This gene is overexpressed in Cervix (29.4), Stomach (13.7), and Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP7 Gene



NURSA nuclear receptor signaling pathways regulating expression of MMP7 Gene:

MMP7

SOURCE GeneReport for Unigene cluster for MMP7 Gene:

Hs.2256
genes like me logo Genes that share expression patterns with MMP7: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MMP7 Gene

Orthologs for MMP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP7 34
  • 80.52 (n)
  • 74.16 (a)
MMP7 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP7 34
  • 81.12 (n)
  • 78.52 (a)
MMP7 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp7 34
  • 74.4 (n)
  • 70.34 (a)
Mmp7 16
Mmp7 35
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP7 34
  • 98.75 (n)
  • 98.5 (a)
MMP7 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp7 34
  • 73.89 (n)
  • 70.34 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP7 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP7 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP7 34
  • 59.62 (n)
  • 53.46 (a)
MMP7 35
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mmp30 35
  • 24 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 36
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16640 34
  • 49.42 (n)
  • 43.86 (a)
rice
(Oryza sativa)
Liliopsida Os10g0557900 34
  • 44.66 (n)
  • 37.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for MMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP7 Gene

ENSEMBL:
Gene Tree for MMP7 (if available)
TreeFam:
Gene Tree for MMP7 (if available)

Paralogs for MMP7 Gene

(18) SIMAP similar genes for MMP7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP7: view

Variants for MMP7 Gene

Sequence variations from dbSNP and Humsavar for MMP7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10502001 - 102,527,862(+) TGACG(C/T)GGGAG reference, missense
rs17884789 - 102,527,598(-) GTGGG(A/G)CAAAG reference, missense
rs17886506 - 102,523,293(-) AGATC(C/T)CCAAA reference, missense
rs1996352 -- 102,525,516(+) TTGCA(C/T)TCACA intron-variant
rs10502002 -- 102,528,652(+) GTTAA(A/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP7 Gene

Variant ID Type Subtype PubMed ID
dgv2136n54 CNV gain 21841781
nsv468854 CNV gain 19166990
nsv469990 CNV gain 18288195
nsv972953 CNV duplication 23825009

Variation tolerance for MMP7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP7 Gene

Human Gene Mutation Database (HGMD)
MMP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP7 Gene

Disorders for MMP7 Gene

MalaCards: The human disease database

(30) MalaCards diseases for MMP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
coronary artery aneurysm
  • coronary artery aneurysms
light chain deposition disease
  • light-chain deposition disease
spastic entropion
focal myositis
  • focal nodular myositis
- elite association - COSMIC cancer census association via MalaCards
Search MMP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP7

Genetic Association Database (GAD)
MMP7
Human Genome Epidemiology (HuGE) Navigator
MMP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP7
genes like me logo Genes that share disorders with MMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP7 Gene

Publications for MMP7 Gene

  1. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PMID: 18648013) Beeghly-Fadiel A. … Zheng W. (Cancer Res. 2008) 3 22 46 65
  2. Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. (PMID: 19643940) Scherf D.B. … Risch A. (Eur. Respir. J. 2010) 3 46 65
  3. Analysis of matrix metalloproteinase-7 expression in eutopic and ectopic endometrium samples from patients with different forms of endometriosis. (PMID: 20007614) Matsuzaki S. … Darcha C. (Hum. Reprod. 2010) 3 22 65
  4. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PMID: 20113256) Yi Y.C. … Yang S.F. (Clin. Chem. Lab. Med. 2010) 3 46 65
  5. Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. (PMID: 20230842) Ban J.Y. … Chung J.H. (Life Sci. 2010) 3 46 65

Products for MMP7 Gene

Sources for MMP7 Gene

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