Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MMP7 Gene

protein-coding   GIFtS: 74
GCID: GC11M102425

Matrix Metallopeptidase 7 (Matrilysin, Uterine)

(Previous names: matrix metalloproteinase 7 (matrilysin, uterine))
(Previous symbol: MPSL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Matrix Metallopeptidase 7 (Matrilysin, Uterine)1 2     matrilysin2
MPSL11 2 3     matrin2
Matrix Metalloproteinase 7 (Matrilysin, Uterine)1 2     Uterine Matrilysin2
Matrix Metalloproteinase-72 3     EC 3.4.24.233
Pump-1 Protease2 3     Matrin3
Uterine Metalloproteinase2 3     PUMP13
MMP-72 3     EC 3.4.248
PUMP-12     

External Ids:    HGNC: 71741   Entrez Gene: 43162   Ensembl: ENSG000001376737   OMIM: 1789905   UniProtKB: P092373   

Export aliases for MMP7 gene to outside databases

Previous GC identifers: GC11M104584 GC11M103748 GC11M101928 GC11M101896 GC11M098318


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MMP7 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans,
fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal
protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the
activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to
chromosome 11q22.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP7 Gene:
MMP7 (matrix metallopeptidase 7 (matrilysin, uterine)) is a protein-coding gene. Diseases associated with MMP7 include pediatric multiple sclerosis, and focal myositis. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237
Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

summary for MMP7 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP7 gene promoter:
         STAT1   p53   AP-1   ATF-2   STAT5A   Tal-1beta   c-Jun   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP7 promoter sequence
   Search Chromatin IP Primers for MMP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q21-q22

MMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102425:  view genomic region     (about GC identifiers)

Start:
102,391,239 bp from pter      End:
102,401,484 bp from pter
Size:
10,246 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237 (See protein sequence)
Recommended Name: Matrilysin precursor  
Size: 267 amino acids; 29677 Da
Cofactor: Binds 2 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
6 PDB 3D structures from and Proteopedia for MMP7:
1MMP (3D)        1MMQ (3D)        1MMR (3D)        2DDY (3D)        2Y6C (3D)        2Y6D (3D)    
Secondary accessions: Q9BTK9

Explore the universe of human proteins at neXtProt for MMP7: NX_P09237

Explore proteomics data for MMP7 at MOPED

3 DME Specific Peptides for MMP7 (P09237)
 PRCGVPD  MQKFFGL  LAHAFAPG 


See MMP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002414.1  
ENSEMBL proteins: 
 ENSP00000260227  
Reactome Protein details: P09237

MMP7 Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant MMP7 Protein
R&D Systems Recombinant & Natural Proteins for MMP7 (MMP-7)
Enzo Life Sciences proteins for MMP7
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for MMP7
OriGene Custom MassSpec
OriGene Custom Protein Services for MMP7
GenScript Custom Purified and Recombinant Proteins Services for MMP7
Novus Biologicals MMP7 Proteins
Novus Biologicals MMP7 Lysates
Sino Biological Recombinant Protein for MMP7
Sino Biological Cell Lysate for MMP7
ProSpec Recombinant Protein for MMP7
Cloud-Clone Corp. Proteins for MMP7

MMP7 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP7
R&D Systems Antibodies for MMP7 (MMP-7)
Cell Signaling Technology (CST) Antibodies for MMP7 
OriGene Antibodies for MMP7
OriGene Custom Antibody Services for MMP7
Novus Biologicals MMP7 Antibodies
Abcam antibodies for MMP7
Cloud-Clone Corp. Antibodies for MMP7
ThermoFisher Antibody for MMP7
LSBio Antibodies in human, mouse, rat for MMP7

MMP7 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MMP7
R&D Systems ELISAs for MMP7 (MMP-7)         (see all)
GenScript MMP7-Activity-based Protease?src=genec Assay for Compound Screening
Enzo Life Sciences assays for MMP7
Cloud-Clone Corp. ELISAs for MMP7
Cloud-Clone Corp. CLIAs for MMP7


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
IUPHAR Guide to PHARMACOLOGY protein family classification: MMP7
Cell-surface protein and extracellular matrix metalloproteinases

Selected InterPro protein domains (see all 7):
 IPR024079 MetalloPept_cat_dom
 IPR021158 Pept_M10A_Zn_BS
 IPR021190 Pept_M10A
 IPR006026 Peptidase_Metallo
 IPR001818 Pept_M10_metallopeptidase

Graphical View of Domain Structure for InterPro Entry P09237

ProtoNet protein and cluster: P09237

1 Blocks protein domain: IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237
Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
enzyme
Similarity: Belongs to the peptidase M10A family


MMP7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MMP7_HUMAN, P09237
Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase
Catalytic activity: Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen
types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)

     Genatlas biochemistry entry for MMP7:
matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass
of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating
angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta
catenin/CF4 and important factor in early tumor growth progression and metastasis

     Enzyme Numbers (IUBMB): EC 3.4.24.231 EC 3.4.242

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004222metalloendopeptidase activity IEA--
GO:0008237metallopeptidase activity ----
GO:0008270zinc ion binding IEA--
     
MMP7 for ontologies           About GeneDecksing


Phenotypes:
     10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp7):
 cardiovascular system  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
 homeostasis/metabolism  immune system  mortality/aging  tumorigenesis  vision/eye 

MMP7 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Mmp7tm1Lmm for MMP7

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP7
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP7

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP7
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP7

miRNA
Products:
    
miRTarBase miRNAs that target MMP7:
hsa-mir-126-3p (MIRT007269), hsa-mir-126-5p (MIRT007268)

Block miRNA regulation of human, mouse, rat MMP7 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate MMP7:
hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
SwitchGear 3'UTR luciferase reporter plasmidMMP7 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MMP7
Predesigned siRNA for gene silencing in human, mouse, rat MMP7

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MMP7

Clone
Products:
     
OriGene clones in human, mouse for MMP7 (see all 7)
OriGene ORF clones in mouse, rat for MMP7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
Sino Biological Human cDNA Clone for MMP7
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MMP7
Browse ESI BIO Cell Lines and PureStem Progenitors for MMP7 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
MMP7_HUMAN, P09237: Secreted, extracellular space, extracellular matrix (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
plasma membrane3
cytoskeleton2
nucleus2
endoplasmic reticulum1
lysosome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005578proteinaceous extracellular matrix IEA--
GO:0005615extracellular space TAS1497627
GO:0031012extracellular matrix ----

MMP7 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for MMP7 About   (see all 16)                                                                                              See pathways by source

SuperPathContained pathways About
1Matrix Metalloproteinases
Matrix Metalloproteinases0.68
Activation of Matrix Metalloproteinases0.37
Inhibition of Matrix Metalloproteinases0.68
2Cell adhesion ECM remodeling
Metalloproteases in connective tissue degradation0.31
Cell adhesion ECM remodeling0.31
3Degradation of the extracellular matrix
Degradation of the extracellular matrix0.43
Extracellular matrix organization0.34
Collagen degradation0.43
4Collagen biosynthesis and modifying enzymes
Collagen formation0.75
Assembly of collagen fibrils and other multimeric structures0.62
5Integrin Pathway
UPA-UPAR Pathway0.56
Transendothelial Migration of Leukocytes0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP7 (see all 6)
    Inhibition of Matrix Metalloproteinases
Colorectal Cancer Metastasis
Transendothelial Migration of Leukocytes
UPA-UPAR Pathway
WNT Signaling

2 Cell Signaling Technology (CST) Pathways for MMP7
    Angiogenesis
Protein Stability

1 GeneGo (Thomson Reuters) Pathway for MMP7
    Cell adhesion ECM remodeling

Selected BioSystems Pathways for MMP7 (see all 6)
    Wnt Signaling Pathway and Pluripotency
Matrix Metalloproteinases
AGE/RAGE pathway
Alpha6-Beta4 Integrin Signaling Pathway
p75(NTR)-mediated signaling


4 Reactome Pathways for MMP7
    Assembly of collagen fibrils and other multimeric structures
Degradation of the extracellular matrix
Collagen degradation
Activation of Matrix Metalloproteinases


1 Kegg Pathway  (Kegg details for MMP7):
    Wnt signaling pathway


MMP7 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP7 (see all 8): 
          Extracellular Matrix & Adhesion Molecules in human mouse rat
          Wound Healing in human mouse rat
          WNT Signaling Pathway in human mouse rat
          Tumor Metastasis in human mouse rat
          Notch Signaling Pathway in human mouse rat

Interactions:

    GeneGlobe Interaction Network for MMP7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MMP7 (P092372, 3 ENSP000002602274) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
InteractantInteraction Details
GeneCardExternal ID(s)
CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
SERPINA1P010093, ENSP000003480684I2D: score=2 STRING: ENSP00000348068
SPP1P104513, ENSP000003785174I2D: score=2 STRING: ENSP00000378517
DCNP075853, ENSP000000527544I2D: score=1 STRING: ENSP00000052754
DEFA1P596653I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002779antibacterial peptide secretion IEA--
GO:0006508proteolysis TAS1497627
GO:0022617extracellular matrix disassembly TAS--
GO:0030198extracellular matrix organization TAS--
GO:0030574collagen catabolic process TAS--

MMP7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for MMP7
  Browse compounds at ApexBio 

Compounds for MMP7 available from Tocris Bioscience    About this table
CompoundAction CAS #
GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
MarimastatBroad spectrum MMP inhibitor[154039-60-8]
GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

1 HMDB Compound for MMP7    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

4 DrugBank Compounds for MMP7    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Marimastat-- 154039-60-8targetantagonist10852638 10669951
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE-- --target--10592235
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID-- --target--10592235
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE-- --target--10592235

Selected Novoseek inferred chemical compound relationships for MMP7 gene (see all 33)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate 69.9 6 11481258 (1), 7896811 (1)
marimastat 56 5 14632921 (2), 16595036 (2)
matrigel 52.5 1 14606648 (1)
auraptene 50.7 3 16979634 (2), 17151446 (1)
vegf 46.5 51 18974372 (4), 15183452 (2), 17115023 (2), 19031137 (2) (see all 22)
hocl 25.3 8 12759346 (4), 11533038 (2), 14670964 (1)
egcg 24.5 7 17928719 (2), 15860507 (1), 17981559 (1)
glyceraldehyde 3-phosphate 18.7 4 8949652 (1), 11757034 (1), 17649785 (1), 16101153 (1)
oligonucleotide 16.3 2 16697739 (1), 9550265 (1)
ag 1478 14.8 2 16311341 (2)



MMP7 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MMP7 gene: 
NM_002423.3  

Unigene Cluster for MMP7:

Matrix metallopeptidase 7 (matrilysin, uterine)
Hs.2256  [show with all ESTs]
Unigene Representative Sequence: BQ688566
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000260227(uc001phb.3) ENST00000533366(uc009yxd.3) ENST00000531200(uc010rus.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MMP7 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate MMP7:
hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
SwitchGear 3'UTR luciferase reporter plasmidMMP7 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MMP7
Predesigned siRNA for gene silencing in human, mouse, rat MMP7
Clone
Products:
     
OriGene clones in human, mouse for MMP7 (see all 7)
OriGene ORF clones in mouse, rat for MMP7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MMP7
OriGene qSTAR qPCR primer pairs in human, mouse for MMP7
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP7
  QuantiTect SYBR Green Assays in human, mouse, rat MMP7
  QuantiFast Probe-based Assays in human, mouse, rat MMP7

Additional mRNA sequence: 

AK222980.1 AK293359.1 AK309687.1 BC003635.2 DQ399600.1 X07819.1 Z11887.1 

4 DOTS entries:

DT.446734  DT.95270459  DT.100022951  DT.95270460 

Selected AceView cDNA sequences (see all 89):

AA975518 BU686947 BM983722 CB111200 AI675414 AI888421 AA344350 AA031513 
AI888609 BQ690859 BI764547 AU155489 BM983702 AI095584 BG741319 BC003635 
CB109665 AA970839 BU589659 BF513409 BI764668 AI377209 BG165117 AW474563 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MMP7 expression in normal human tissues (normalized intensities)      MMP7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTAAATTTAA
MMP7 Expression
About this image


MMP7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         HyStem+BMP4-induced 4D20.8 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
         HyStem+BMP4-induced 4D20.8 cells
 
 Epidermis (Integumentary System)
         MSC-containing human skin substitute (Grafix)
 
 Testis (Reproductive System)
         Sertoli cells Seminiferous Tubules
 
 Gall Bladder (Hepatobiliary System)
MMP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MMP7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2256
    Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP7 (see all 8): 
          Extracellular Matrix & Adhesion Molecules in human mouse rat
          Wound Healing in human mouse rat
          WNT Signaling Pathway in human mouse rat
          Tumor Metastasis in human mouse rat
          Notch Signaling Pathway in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for MMP7
OriGene qSTAR qPCR primer pairs in human, mouse for MMP7
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP7
QuantiTect SYBR Green Assays in human, mouse, rat MMP7
QuantiFast Probe-based Assays in human, mouse, rat MMP7
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mmp71 , 5 matrix metallopeptidase 71, 5 74.4(n)1
70.34(a)1
  9 (2.46 cM)5
173931  NM_010810.41  NP_034940.21 
 76920905 
chicken
(Gallus gallus)
Aves MMP71 matrix metallopeptidase 7 (matrilysin, uterine) 59.62(n)
53.46(a)
  418983  NM_001006278.1  NP_001006278.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
45(a)
many ↔ many
3(192236501-192241705)
zebrafish
(Danio rerio)
Actinopterygii mmp306
matrix metallopeptidase 30
24(a)
1 ↔ 1
10(40051610-40071814) ENSDARG00000045887
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G166401 AT4G16640 49.42(n)
43.86(a)
  827365  NM_117765.3  NP_193397.1 
rice
(Oryza sativa)
Liliopsida Os10g05579001 Os10g0557900 44.66(n)
37.94(a)
  4349359  NM_001071893.2  NP_001065361.2 


ENSEMBL Gene Tree for MMP7 (if available)
TreeFam Gene Tree for MMP7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for MMP7 gene
MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP242  MMP152  
MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
18 SIMAP similar genes for MMP7 using alignment to 2 protein entries:     MMP7_HUMAN (see all proteins):
MMP2    MMP20    MMP1    MMP12    MMP17    MMP13
MMP8    MMP26    MMP27    MMP3    MMP10    MMP11
MMP14    MMP24    MMP25    MMP16    MMP19    mmp20

MMP7 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for MMP7 (see all 358)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1886993871,2
--102390840(+) TCTGCA/GTTGGC 1 -- int10--------
rs1435951291,2
--102390857(+) AAAAGA/GGAAGG 1 -- int10--------
rs1925378221,2
--102390994(+) TTGTGA/GGAAGA 1 -- int10--------
rs178849401,2
C,F--102391033(-) GGCCCA/C/GTGCTC 1 -- int11NS 180
rs1840726031,2
--102391034(+) AGCACA/GGGCCA 1 -- int10--------
rs178825051,2
C,F--102391036(-) TGTGGC/TCCGTG 1 -- int11Minor allele frequency- T:0.01NS 178
rs178845961,2
C,F--102391163(-) AATCCC/TACCAC 1 -- int12Minor allele frequency- T:0.02NS WA 272
rs1911893941,2
--102391172(+) TTCTTC/TTTTTG 1 -- int10--------
rs1837891921,2
--102391204(+) TATAGC/TATGTC 1 -- int10--------
rs770305791,2
C--102391273(+) TATTTG/ATGTAT 1 -- ut312Minor allele frequency- A:0.15WA 120

HapMap Linkage Disequilibrium report for MMP7 (102391239 - 102401484 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MMP7:    About this table    
Variant IDTypeSubtypePubMed ID
nsv469990CNV Gain18288195
nsv468854CNV Gain19166990

Human Gene Mutation Database (HGMD): MMP7
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MMP7
DNA2.0 Custom Variant and Variant Library Synthesis for MMP7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 178990    OMIM disorders: --

Selected diseases for MMP7 (see all 119):    About MalaCards
pediatric multiple sclerosis    focal myositis    encephalomyelitis    ovarian mucinous neoplasm
thymic epithelial tumor    carotid artery disease    biliary atresia    adenomyosis
uterine carcinosarcoma    h. pylori infection    refractive error    hepatocellular adenoma
pulmonary fibrosis    desmoid tumor    renal dysplasia    dermatitis herpetiformis
cryoglobulinemia    idiopathic pulmonary fibrosis    keratoacanthoma    cutaneous lupus erythematosus

2 diseases from the University of Copenhagen DISEASES database for MMP7:
Carcinoma     Colorectal cancer

MMP7 for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for MMP7 gene (see all 93)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis 68.1 187 15966224 (6), 15142461 (5), 15143943 (5), 16536985 (5) (see all 82)
colon cancer 63.6 46 19728912 (7), 11781281 (3), 15138601 (2), 19002110 (2) (see all 19)
tumors 61.1 306 10713661 (7), 19956372 (5), 11832095 (4), 11212252 (4) (see all 99)
colorectal cancer 58.4 53 15966224 (3), 18636198 (3), 11832095 (2), 11801551 (2) (see all 30)
cancer 56.7 138 17145820 (5), 15623600 (4), 15865605 (4), 15175941 (3) (see all 74)
carcinoma 52.2 80 10502722 (7), 11900228 (4), 9583735 (4), 17507610 (4) (see all 38)
colon carcinoma 49.8 8 9220495 (3), 11217438 (1), 14647460 (1), 9626346 (1) (see all 5)
colorectal carcinoma 49.6 26 16474169 (2), 17649785 (2), 7889484 (2), 11355941 (2) (see all 14)
aggressiveness 48.1 7 11900228 (1), 8949652 (1), 7889484 (1), 14691910 (1)
adenoma 47.3 29 17009118 (4), 15800927 (2), 15634446 (2), 18500535 (2) (see all 17)

Genetic Association Database (GAD): MMP7
Human Genome Epidemiology (HuGE) Navigator: MMP7 (52 documents)

Export disorders for MMP7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MMP7 gene, integrated from 10 sources (see all 825):
(articles sorted by number of sources associating them with MMP7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PubMed id 18648013)1, 4, 9 Beeghly-Fadiel A....Zheng W. (Cancer Res. 2008)
  2. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PubMed id 20113256)1, 4, 9 Yi Y.C....Yang S.F. (Clin. Chem. Lab. Med. 2010)
  3. Genetic polymorphisms in the MMP-7 gene and breast cancer survival. (PubMed id 18798254)1, 4, 9 Beeghly-Fadiel A....Zheng W. (Int. J. Cancer 2009)
  4. A novel nonsynonymous variant of matrix metalloproteinase-7 confers risk of liver cirrhosis. (PubMed id 19676133)1, 4, 9 Hung T.M....Chang M.F. (Hepatology 2009)
  5. Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China. (PubMed id 16455621)1, 4, 9 Shan K....Yan L. (Mol. Hum. Reprod. 2006)
  6. Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. (PubMed id 19643940)1, 4, 9 Scherf D.B....Risch A. (Eur. Respir. J. 2010)
  7. Transforming growth factor-B1 and matrix metalloproteinase-7 promoter variants induce risk for Helicobacter pylori-associated gastric precancerous lesions. (PubMed id 19317620)1, 4, 9 Achyut B.R....Mittal B. (DNA Cell Biol. 2009)
  8. Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population. (PubMed id 19132754)1, 4, 9 Jin G....Shen H. (Int. J. Cancer 2009)
  9. Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. (PubMed id 18958543)1, 4, 9 Sugimoto M....Hishida A. (J. Gastroenterol. 2008)
  10. MMP-7 (-181A&gt;G) promoter polymorphisms and risk for cervical cancer. (PubMed id 18448157)1, 4, 9 Singh H....Mittal B. (Gynecol. Oncol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 4316 HGNC: 7174 AceView: MMP7 Ensembl:ENSG00000137673 euGenes: HUgn4316
ECgene: MMP7 Kegg: 4316 H-InvDB: MMP7

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for MMP7 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP7 Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp7/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for MMP7 gene:
Search GeneIP for patents involving MMP7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 Browse Small Molecules at EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP7
 Browse Kits and Assays available from EMD Millipore
 EMD Millipore Purified and/or Recombinant MMP7 Protein
 
 EMD Millipore genomic analysis products

  
 Antibodies for MMP7 (MMP-7)   Browse Cell Culture Products  
 ELISAs for MMP7 (MMP-7)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 ELISpot/FluoroSpot Kits/Development Modules for MMP7 (MMP-7)   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for MMP7 (MMP-7)  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for MMP7 (MMP-7)   Browse Stem Cell Products  
 Browse cDNA Clones   Proteome Profiler Antibody Arrays for MMP7 (MMP-7)  
 OriGene Antibodies for MMP7   OriGene RNAi products in human, mouse, rat for MMP7  
 OriGene qPCR primer pairs and template standards for MMP7   OriGene Protein Over-expression Lysate for MMP7  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for MMP7  
 OriGene qSTAR qPCR primer pairs in human, mouse for MMP7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for MMP7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for MMP7   OriGene Custom Protein Services for MMP7  

 
 
 Block miRNA regulation of human, mouse, rat MMP7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MMP7
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP7 Predesigned siRNA for gene silencing in human, mouse, rat MMP7
 QuantiFast Probe-based Assays in human, mouse, rat MMP7 QuantiTect SYBR Green Assays in human, mouse, rat MMP7
 PCR Arrays including human, mouse, rat MMP7 Search Chromatin IP Primers for MMP7
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP7  GeneGlobe Interaction Network for MMP7
 Regulatory tfbs in MMP7 promoter
 GenScript Custom Purified and Recombinant Proteins Services for MMP7 GenScript cDNA clones with any tag delivered in your preferred vector for MMP7
 GenScript MMP7-Activity-based typehere Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for MMP7
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Antibodies & Assays for MMP7 

 Tocris compounds for MMP7
 Proteins for MMP7
 Cell Lysates for MMP7
 cDNA Clones for MMP7
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Assays/Drugs/Proteins for MMP7
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 MMP7 antibodies
 MMP7 proteins
 MMP7 lysates
 Antibodies for MMP7
 See all of Abcam's Antibodies, Kits and Proteins for MMP7
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for MMP7
 Proteins for MMP7
 Antibodies for MMP7
 ELISAs for MMP7
 CLIAs for MMP7



 Browse ESI BIO Cell Lines and PureStem Progenitors for MMP7
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7
 SwitchGear 3'UTR luciferase reporter plasmids for MMP7
 SwitchGear Promoter luciferase reporter plasmids for MMP7
 ThermoFisher Antibody for MMP7
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP7
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP7
 LSBio Antibodies in human, mouse, rat for MMP7
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      MMP7 gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4