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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP7 Gene

protein-coding GIFtS: 72
GCID: GC11M102425

matrix metallopeptidase 7 (matrilysin, uterine)

(Previous names: matrix metalloproteinase 7 (matrilysin, uterine) )
(Previous symbol: MPSL1)

Explore 135 diseases affiliated with
MMP7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 7 (Matrilysin, Uterine)¹ ²		Matrilysin¹
MPSL1¹ ² ³		Matrin³
PUMP-1¹ ²		Uterine Matrilysin²
Matrix Metalloproteinase 7 (Matrilysin, Uterine)¹ ²		EC 3.4.24.23³
Matrix Metalloproteinase-7² ³		Matrin³
Pump-1 Protease² ³		PUMP1³
Uterine Metalloproteinase² ³		EC 3.4.24⁸
MMP-7² ³

External Ids:	HGNC: 7174¹	Entrez Gene: 4316²	Ensembl: ENSG00000137673⁷	OMIM: 178990⁵	UniProtKB: P09237³

Export aliases for MMP7 gene to outside databases

Previous GC identifers: GC11M104584 GC11M103748 GC11M101928 GC11M101896 GC11M098318

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP7:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and

casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is

involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal

mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237

Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

summary for MMP7:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP7 gene promoter:
STAT1 p53 AP-1 ATF-2 STAT5A Tal-1beta c-Jun ITF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP7 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q21-q22

MMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP7 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102425: view genomic region (about GC identifiers)

Start:	102,391,239 bp from pter	End:	102,401,484 bp from pter
Size:	10,246 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237 (See protein sequence)

Recommended Name: Matrilysin precursor

Size: 267 amino acids; 29677 Da

Cofactor: Binds 2 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

6 PDB 3D structures from and Proteopedia for MMP7:

1MMP (3D)

1MMQ (3D)

1MMR (3D)

2DDY (3D)

2Y6C (3D)

2Y6D (3D)

Secondary accessions: Q9BTK9

Explore the universe of human proteins at neXtProt for MMP7: NX_P09237

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09237

3 DME Specific Peptides for MMP7 (P09237)

PRCGVPD

MQKFFGL

LAHAFAPG

MMP7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002414.1

ENSEMBL proteins:

ENSP00000260227

Reactome Protein details: P09237
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MMP7 Protein
	R&D Systems Recombinant & Natural Proteins for MMP7 (MMP-7)
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	GenScript Custom Purified and Recombinant Proteins Services for MMP7
	Novus Biologicals MMP7 Proteins Novus Biologicals MMP7 Lysates
	Sino Biological Recombinant Protein for MMP7
	ProSpec Recombinant Protein for MMP7
	Uscn Proteins for MMP7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	1497627

MMP7 for ontologies About GeneDecksing

MMP7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP7
	R&D Systems Antibodies for MMP7 (MMP-7)
	Cell Signaling Technology (CST) Antibodies for MMP7
	OriGene Antibodies: MMP7 OriGene Custom Antibody Services for MMP7
	GenScript Custom Superior Antibodies Services for MMP7
	Novus Biologicals MMP7 Antibodies
	Search for Antibodies for MMP7 at Abcam
	Uscn Antibodies for MMP7
	ThermoFisher Antibodies for MMP7

Assay Products for MMP7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP7 (MMP-7) (see all)
	GenScript MMP7-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP7
	Uscn ELISAs and CLIAs for MMP7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP7 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR006026 Peptidase_Metallo

IPR001818 Pept_M10_metallopeptidase

Graphical View of Domain Structure for InterPro Entry P09237

ProtoNet protein and cluster: P09237

1 Blocks protein family: IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP7_HUMAN, P09237

Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

Catalytic activity: Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen types

I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)

Genatlas biochemistry entry for MMP7:

matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass of

MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating

angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta catenin/CF4 and

important factor in early tumor growth progression and metastasis

Enzyme Numbers (IUBMB): EC 3.4.24.23¹ EC 3.4.24²

miRNA Products:		OriGene 3'-UTR Clone: MMP7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP7
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP7:
		hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
		SwitchGear 3'UTR luciferase reporter plasmid: MMP7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP7 (see all 7) OriGene shRNA RFP: MMP7 OriGene siRNA: MMP7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP7 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
		Sino Biological Human cDNA Clone for MMP7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP7
		Search LifeMap BioReagents cell lines for MMP7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP7 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Mmp7^tm1Lmm for MMP7
     9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp7):

cardiovascular system	cellular	digestive/alimentary	growth/size	homeostasis/metabolism
immune system	mortality/aging	tumorigenesis	vision/eye

MMP7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Assembly of collagen fibrils and other multimeric structures	0.65

Cell adhesion_ECM remodeling

	Cell adhesion_ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion ECM remodeling	1.00

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

Integrin Pathway

UPA-UPAR Pathway

0.51

Transendothelial Migration of Leukocytes

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MMP7

	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP7 (see all 6)

	Inhibition of Matrix Metalloproteinases
	Colorectal Cancer Metastasis
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	WNT Signaling

2 Cell Signaling Technology (CST) Pathways for MMP7

	Angiogenesis
	Protein Stability

1 GeneGo (Thomson Reuters) Pathway for MMP7

Cell adhesion ECM remodeling

5/6 BioSystems Pathways for MMP7 (see all 6)

	Matrix Metalloproteinases
	Wnt Signaling Pathway and Pluripotency
	AGE/RAGE pathway
	Alpha6-Beta4 Integrin Signaling Pathway
	Syndecan-1-mediated signaling events

5/7 Reactome Pathways for MMP7 (see all 7)

	Extracellular matrix organization
	Assembly of collagen fibrils and other multimeric structures
	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
	Degradation of the extracellular matrix
	Collagen formation

1 Kegg Pathway (Kegg details for MMP7):

Wnt signaling pathway

MMP7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for MMP7 (P09237^{2, 3} ENSP00000260227⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD151	P48509³, ENSP00000324101⁴	I2D: score=2 STRING: ENSP00000324101
SERPINA1	P01009³, ENSP00000348068⁴	I2D: score=2 STRING: ENSP00000348068
SPP1	P10451³, ENSP00000378517⁴	I2D: score=2 STRING: ENSP00000378517
DCN	P07585³, ENSP00000052754⁴	I2D: score=1 STRING: ENSP00000052754
DEFA1	P59665³	I2D: score=1

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002779	antibacterial peptide secretion	IEA	--
GO:0006508	proteolysis	IEA	--
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030574	collagen catabolic process	IEA	--

MMP7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP7 for compounds About GeneDecksing

EMD Millipore small molecules for MMP7:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP7

Compounds for MMP7 available from Tocris Bioscience About this table

Compound	Action	CAS #
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

4 DrugBank Compounds for MMP7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	antagonist	10852638 10669951
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE	--	--	target	--	10592235
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID	--	--	target	--	10592235
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE	--	--	target	--	10592235

10/33 Novoseek chemical compound relationships for MMP7 gene (see all 33) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate	69.9	6	11481258 (1), 7896811 (1)
marimastat	56	5	14632921 (2), 16595036 (2)
matrigel	52.5	1	14606648 (1)
auraptene	50.7	3	16979634 (2), 17151446 (1)
vegf	46.5	51	18974372 (4), 15183452 (2), 17115023 (2), 19031137 (2) (see all 22)
hocl	25.3	8	12759346 (4), 11533038 (2), 14670964 (1)
egcg	24.5	7	17928719 (2), 15860507 (1), 17981559 (1)
glyceraldehyde 3-phosphate	18.7	4	8949652 (1), 11757034 (1), 17649785 (1), 16101153 (1)
oligonucleotide	16.3	2	16697739 (1), 9550265 (1)
ag 1478	14.8	2	16311341 (2)

Search CenterWatch for drugs/clinical trials and news about MMP7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP7 gene:

NM_002423.3

Unigene Cluster for MMP7:

Matrix metallopeptidase 7 (matrilysin, uterine)

Hs.2256 [show with all ESTs]

Unigene Representative Sequence: BQ688566

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260227(uc001phb.3) ENST00000533366(uc009yxd.3) ENST00000531200(uc010rus.1)

miRNA Products:		OriGene 3'-UTR Clone: MMP7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP7
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP7:
		hsa-miR-3143 hsa-miR-543 hsa-miR-548aa
		SwitchGear 3'UTR luciferase reporter plasmid: MMP7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP7 (see all 7) OriGene shRNA RFP: MMP7 OriGene siRNA: MMP7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP7 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP7 (NM_002423)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP7

Additional cDNA sequence:

AK222980.1 AK293359.1 AK309687.1 BC003635.2 DQ399600.1 X07819.1 Z11887.1

4 DOTS entries:

DT.446734 DT.95270459 DT.100022951 DT.95270460

24/89 AceView cDNA sequences (see all 89):

AA031513 CB111200 AA975518 AI675414 BM983722 AI888609 AU155489 BU686947

BM983702 BI764547 BQ690859 AI888421 AA344350 AI095584 AW298180 BX118049

AI377209 AA299556 BF513409 CB109665 BU589659 BG386032 AA031514 AI871918

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAAATTTAA

About this image

MMP7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See MMP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP7

SOURCE GeneReport for Unigene cluster: Hs.2256

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP7 (see all 8):

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

WNT Signaling Pathway in human mouse rat

Tumor Metastasis in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP7

In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP7¹	matrix metallopeptidase 7 (matrilysin, uterine)	59.62(n) 53.46(a)		418983 NM_001006278.1 NP_001006278.1
zebrafish (Danio rerio)	Actinopterygii	mmp16a⁶ CR848664.1⁶	--	22(a)	possible ortholog 1 ↔ 1	24(32795678-32875906) 15(24890159-24906607)
worm (Caenorhabditis elegans)	Secernentea	H36L18.1⁶	Protein H36L18.1	16(a)	possible ortholog	X(12647047-12651417)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G16640¹	matrix metalloprotease domain-containing protein	49.71(n) 43.91(a)		827365 NM_117765.3 NP_193397.1
rice (Oryza sativa)	Liliopsida	Os10g0557900¹	hypothetical protein	45.71(n) 40.51(a)		4349359 NM_001071893.2 NP_001065361.2

ENSEMBL Gene Tree for MMP7 (if available)
TreeFam Gene Tree for MMP7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MMP7 gene

MMP21² MMP23B² MMP19² MMP26²

18 SIMAP similar genes for MMP7 using alignment to 2 protein entries: MMP7_HUMAN (see all proteins):

MMP2 MMP20 MMP1 MMP12 MMP17 MMP13

MMP8 MMP26 MMP27 MMP3 MMP10 MMP11

MMP14 MMP24 MMP25 MMP16 MMP19 mmp20

MMP7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188699387^1,2		--	102390840(+)	`TCTGCA/GTTGGC`	1	--	int¹		0	--	--	--	--
rs143595129^1,2		--	102390857(+)	`AAAAGA/GGAAGG`	1	--	int¹		0	--	--	--	--
rs192537822^1,2		--	102390994(+)	`TTGTGA/GGAAGA`	1	--	int¹		0	--	--	--	--
rs17884940^1,2	C,	--	102391033(-)	`GGCCCA/C/GTGCTC`	1	--	int¹		1		NS	180
rs184072603^1,2		--	102391034(+)	`AGCACA/GGGCCA`	1	--	int¹		0	--	--	--	--
rs17882505^1,2	C,	--	102391036(-)	`TGTGGC/TCCGTG`	1	--	int¹		1		NS	178
rs17884596^1,2	C,F,	--	102391163(-)	`AATCCC/TACCAC`	1	--	int¹		2		NS WA	272
rs191189394^1,2		--	102391172(+)	`TTCTTC/TTTTTG`	1	--	int¹		0	--	--	--	--
rs183789192^1,2		--	102391204(+)	`TATAGC/TATGTC`	1	--	int¹		0	--	--	--	--
rs77030579^1,2	C,	--	102391273(+)	`TATTTG/ATGTAT`	1	--	ut3¹		2		WA	120

HapMap Linkage Disequilibrium report for MMP7 (102391239 - 102401484 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP7: --
Human Gene Mutation Database (HGMD): MMP7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP7 for disorders           About GeneDecksing

OMIM gene information: 178990    OMIM disorders: --

20/135 diseases for MMP7 (see all 135):    About MalaCards

encephalomyelitis arthritis human t-cell leukemia virus type 1 familial adenomatous polyposis

biliary atresia uterine carcinosarcoma ectopic pregnancy ovarian mucinous neoplasm

thymic epithelial tumor severe combined immunodeficiency carcinoma dermatitis herpetiformis

macular degeneration carotid artery disease bronchiolitis obliterans pulmonary fibrosis

2 diseases from the University of Copenhagen DISEASES database for MMP7:

Carcinoma Colorectal cancer

10/93 Novoseek disease relationships for MMP7 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	68.1	187	15966224 (6), 15142461 (5), 15143943 (5), 16536985 (5) (see all 82)
colon cancer	63.6	46	19728912 (7), 11781281 (3), 15138601 (2), 19002110 (2) (see all 19)
tumors	61.1	306	10713661 (7), 19956372 (5), 11832095 (4), 11212252 (4) (see all 99)
colorectal cancer	58.4	53	15966224 (3), 18636198 (3), 11832095 (2), 11801551 (2) (see all 30)
cancer	56.7	138	17145820 (5), 15623600 (4), 15865605 (4), 15175941 (3) (see all 74)
carcinoma	52.2	80	10502722 (7), 11900228 (4), 9583735 (4), 17507610 (4) (see all 38)
colon carcinoma	49.8	8	9220495 (3), 11217438 (1), 14647460 (1), 9626346 (1) (see all 5)
colorectal carcinoma	49.6	26	16474169 (2), 17649785 (2), 7889484 (2), 11355941 (2) (see all 14)
aggressiveness	48.1	7	11900228 (1), 8949652 (1), 7889484 (1), 14691910 (1)
adenoma	47.3	29	17009118 (4), 15800927 (2), 15634446 (2), 18500535 (2) (see all 17)

Genetic Association Database (GAD): MMP7
Human Genome Epidemiology (HuGE) Navigator: MMP7 (52 documents)

Export disorders for MMP7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MMP7 gene, integrated from 9 sources (see all 802):
(articles sorted by number of sources associating them with MMP7)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China. (PubMed id 16278009)^{1, 4, 9} Li Y....Fang S. (2006)
Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. (PubMed id 16356191)^{1, 4, 9} Rodriguez-Lopez J....Gonzalez A. (2006)
The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. (PubMed id 15930031)^{1, 4, 9} Zhang J....Kuang G. (2005)
Allele-specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patients. (PubMed id 11701474)^{1, 4, 9} Jormsjo S....Eriksson P. (2001)
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line. (PubMed id 2253219)^{1, 2, 9} Miyazaki K.... Umeda M. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22. (PubMed id 8978768)^{1, 3} Knox J.D....Bowden G.T. (1996)
Matrilysin-inhibitor complexes: common themes among metalloproteases. (PubMed id 7756291)^{1, 2} Browner M.F.... Castelhano A.L. (1995)
Structure and expression of the human gene for the matrix metalloproteinase matrilysin. (PubMed id 8294454)^{1, 2} Gaire M....Matrisian L.M. (1994)
Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. (PubMed id 1497627)^{1, 2} Marti H.P.... Lovett D.H. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4316	HGNC: 7174	AceView: MMP7	Ensembl:ENSG00000137673	euGenes: HUgn4316
ECgene: MMP7	Kegg: 4316	H-InvDB: MMP7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP7	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp7/

Intellectual Property for MMP7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP7 gene:
Search GeneIP for patents involving MMP7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MMP7 Gene

matrix metallopeptidase 7 (matrilysin, uterine)

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LUNG TUMOR
familial adenomatous polyposis
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Endometriosis
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ADENOCARCINOMA LUNG
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MMP7 Gene

matrix metallopeptidase 7 (matrilysin, uterine)

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