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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP3 Gene

protein-coding GIFtS: 74
GCID: GC11M102706

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

(Previous names: matrix metalloproteinase 3 (stromelysin 1, progelatinase)...)
(Previous symbols: STMY1, STMY)

Explore 233 diseases affiliated with
MMP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase)¹ ²		CHDS6² ⁵
STMY1¹ ² ³ ⁵		STR1²
STMY¹ ²		Proteoglycanase¹
Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase)¹ ²		Stromelysin-1¹
Matrix Metalloproteinase-3² ³		Transin-1³
MMP-3² ³		Transin-1³
SL-1² ³		EC 3.4.24⁸
EC 3.4.24.17³ ⁸

External Ids:	HGNC: 7173¹	Entrez Gene: 4314²	Ensembl: ENSG00000149968⁷	OMIM: 185250⁵	UniProtKB: P08254³

Export aliases for MMP3 gene to outside databases

Previous GC identifers: GC11M104900 GC11M104063 GC11M102695 GC11M102199 GC11M102200 GC11M102211 GC11M098634

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP3:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III,

IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of

atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome

11q22.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and

cartilage proteoglycans. Activates procollagenase

summary for MMP3:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP3 gene promoter:
SRF Sox5 AP-1 SRF (504 AA) HNF-1A SRY HNF-1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP3 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3

MMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102706: view genomic region (about GC identifiers)

Start:	102,706,528 bp from pter	End:	102,714,534 bp from pter
Size:	8,007 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254 (See protein sequence)

Recommended Name: Stromelysin-1 precursor

Size: 477 amino acids; 53977 Da

Cofactor: Binds 4 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

6/38 PDB 3D structures from and Proteopedia for MMP3 (see all 38):

1B3D (3D)

1B8Y (3D)

1BIW (3D)

1BM6 (3D)

1BQO (3D)

1C3I (3D)

Secondary accessions: B2R8B8 Q3B7S0 Q6GRF8

Explore the universe of human proteins at neXtProt for MMP3: NX_P08254

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08254

4/13 DME Specific Peptides for MMP3 (P08254) (see all 13)

HSLGLFH

GEADIMI

FWRKSLR

GIQSLYG

MMP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002413.1

ENSEMBL proteins:

ENSP00000299855 ENSP00000398346 ENSP00000435255

Reactome Protein details: P08254
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MMP3 Protein
	R&D Systems Recombinant & Natural Proteins for MMP3 (MMP-3)
	Enzo Life Sciences proteins for MMP3
	OriGene Purified Protein: MMP3 OriGene Protein Over-expression Lysate: MMP3 OriGene Custom Protein Services for MMP3
	GenScript Custom Purified and Recombinant Proteins Services for MMP3
	Novus Biologicals MMP3 Proteins Novus Biologicals MMP3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MMP3
	Uscn Proteins for MMP3

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	3360803
GO:0005634	nucleus	--	--
GO:0030425	dendrite	--	--

MMP3 for ontologies About GeneDecksing

MMP3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP3
	R&D Systems Antibodies for MMP3 (MMP-3)
	OriGene Antibodies: MMP3 OriGene Custom Antibody Services for MMP3
	GenScript Custom Superior Antibodies Services for MMP3
	Novus Biologicals MMP3 Antibodies
	Abcam antibodies for MMP3
	Uscn Antibodies for MMP3
	ThermoFisher Antibody for MMP3

Assay Products for MMP3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP3 (MMP-3) (see all)
	GenScript MMP3-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP3
	Uscn ELISAs and CLIAs for MMP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP3 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P08254

ProtoNet protein and cluster: P08254

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and

cartilage proteoglycans. Activates procollagenase

Catalytic activity: Preferential cleavage where P1', P2' and P3' are hydrophobic residues

Genatlas biochemistry entry for MMP3:

matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing

bone,interacting with ZBP89,playing a role in tumor metastasis

Enzyme Numbers (IUBMB): EC 3.4.24.17¹ ² EC 3.4.24²

miRNA Products:		OriGene 3'-UTR Clone: MMP3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP3:
		hsa-miR-146b-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MMP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP3 (see all 7) OriGene shRNA RFP: MMP3 OriGene siRNA: MMP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP3 (NM_002422)
		Sino Biological Human cDNA Clone for MMP3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP3
		Search LifeMap BioReagents cell lines for MMP3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0032403	protein complex binding	--	--

MMP3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MMP3:

Decreased circadian period len

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Mmp3^tm1Mrl for MMP3
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp3):

homeostasis/metabolism

immune system

nervous system

skeleton

MMP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Assembly of collagen fibrils and other multimeric structures	0.65

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

	Immune response Oncostatin M signaling via MAPK in human cells	0.39			Oncostatin M Signaling Pathway	0.15
	Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for MMP3

	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Immune response Oncostatin M signaling via MAPK in human cells
	Metalloproteases in connective tissue degradation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP3

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

3 GeneGo (Thomson Reuters) Pathways for MMP3

	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Immune response Oncostatin M signaling via MAPK in human cells

3 BioSystems Pathways for MMP3

	Oncostatin M Signaling Pathway
	Matrix Metalloproteinases
	p75(NTR)-mediated signaling

5/13 Reactome Pathways for MMP3 (see all 13)

	Assembly of collagen fibrils and other multimeric structures
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	EGFR Transactivation by Gastrin
	Collagen formation

1 Kegg Pathway (Kegg details for MMP3):

Rheumatoid arthritis

MMP3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for MMP3 (P08254^{2, 3} ENSP00000299855⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPOCK3	Q9BQ16³, ENSP00000350153⁴	I2D: score=2 STRING: ENSP00000350153
CCL2	P13500³, ENSP00000225831⁴	I2D: score=1 STRING: ENSP00000225831
CCL7	P80098³, ENSP00000200307⁴	I2D: score=1 STRING: ENSP00000200307
DCN	P07585³, ENSP00000052754⁴	I2D: score=1 STRING: ENSP00000052754
HAPLN1	P10915³, ENSP00000274341⁴	I2D: score=1 STRING: ENSP00000274341

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0006508	proteolysis	IEA	--
GO:0007565	female pregnancy	--	--
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--

MMP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP3 for compounds About GeneDecksing

EMD Millipore small molecules for MMP3:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP3

Compounds for MMP3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]
UK 370106	Highly selective MMP-3 and MMP-12 inhibitor	[230961-21-4]

2 HMDB Compounds for MMP3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

10/22 DrugBank Compounds for MMP3 (see all 22) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide	--	--	target	--	17139284 17016423 10592235
5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione	--	--	target	--	17139284 17016423 10592235
A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor	--	--	target	--	17139284 17016423 10592235
N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide	--	--	target	--	17139284 17016423 10592235
N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide	--	--	target	--	17139284 17016423 10592235
R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid	--	--	target	--	17139284 17016423 10592235
(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine	--	--	target	--	17139284 17016423
1-Methyloxy-4-Sulfone-Benzene	--	--	target	--	17139284 17016423
3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid	--	--	target	--	17139284 17016423
3-Methylpyridine	--	108-99-6	target	--	17139284 17016423

10/120 Novoseek chemical compound relationships for MMP3 gene (see all 120) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate	84.3	20	2383557 (3), 8195131 (1), 9930993 (1), 2176865 (1) (see all 10)
n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid	76.8	6	12841876 (1), 19834065 (1), 15814801 (1)
ilomastat	68.3	1	14611841 (1)
hydroxamate	56.2	7	16603129 (2), 18029177 (1), 10521266 (1)
pge2	48	87	15948687 (6), 14981131 (4), 17214881 (4), 19835666 (4) (see all 30)
matrigel	47.7	6	11419692 (4), 12379519 (1), 20188714 (1)
infliximab	46.7	29	17156669 (4), 17552048 (2), 19357521 (2), 15478146 (2) (see all 15)
vegf	43.5	94	15571312 (6), 15455259 (5), 18363112 (5), 11308991 (4) (see all 41)
latanoprost	42.2	13	11027004 (4), 14638715 (2), 18971237 (2), 16505029 (2) (see all 6)
keratan sulfate	40.9	6	9920023 (1), 14613270 (1), 12202124 (1), 7719956 (1)

Search CenterWatch for drugs/clinical trials and news about MMP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP3 gene:

NM_002422.3

Unigene Cluster for MMP3:

Matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Hs.375129 [show with all ESTs]

Unigene Representative Sequence: AK223291

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000299855(uc001phj.1) ENST00000434103 ENST00000524478

miRNA Products:		OriGene 3'-UTR Clone: MMP3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP3:
		hsa-miR-146b-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MMP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP3 (see all 7) OriGene shRNA RFP: MMP3 OriGene siRNA: MMP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP3 (NM_002422)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP3

Additional cDNA sequence:

AK223283.1 AK223291.1 AK313310.1 BC069676.1 BC069716.1 BC074815.2 BC074869.2 BC105954.1

BC107490.1 BC107491.1 DQ399598.1 J03209.1 X05232.1

10 DOTS entries:

DT.313463 DT.120702923 DT.99997921 DT.99940879 DT.100035204 DT.100651118 DT.120702977 DT.120702989

DT.99999491 DT.106379

24/209 AceView cDNA sequences (see all 209):

BQ181107 AA535129 CF126566 BC074815 BQ771783 AW291450 CA430963 BQ182789

CD365864 CD614797 CA413861 CF132244 CN479902 CA414582 CA412479 BU623701

C02073 BQ019029 BM988940 BM991379 BG928156 BP346005 BP345369 BP345500

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCAGGCT

About this image

MMP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Vascular Adipose

Stromal Vascular Preadipocyte Progenitor Cells

Selective marker (cell-identifying gene)

Adipose

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

See MMP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP3

SOURCE GeneReport for Unigene cluster: Hs.375129

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP3 (see all 7):

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Th17 Response in human mouse rat

Atherosclerosis in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP3
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP3 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC428086¹	stromelysin-1-like	62.3(n) 54.12(a)		428086 XM_425644.3 XP_425644.3
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	55(a) 52(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(192100693-192114354) 3(192049443-192058710)
tropical clawed frog (Xenopus tropicalis)	Amphibia	CF218175.1²	--	71.85(n)		CF218175.1
zebrafish (Danio rerio)	Actinopterygii	mmp13a⁶ mmp16a⁶	matrix metallopeptidase 16a (membrane-inserted)	44(a) 21(a)	1 ↔ many possible ortholog	10(39959934-39979810) 24(32795678-32875906)
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	44(a)		V(2905685-2909407) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT1G59970⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	27(a) 26(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 1(22073534-22074876)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	8(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 10(21883516-21885765)

ENSEMBL Gene Tree for MMP3 (if available)
TreeFam Gene Tree for MMP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP3 gene

MMP13² MMP20² MMP8² MMP14² MMP9² MMP16² MMP2² MMP25²

MMP24² MMP15² MMP11² MMP27² MMP17² MMP10² MMP1²

17 SIMAP similar genes for MMP3 using alignment to 4 protein entries: MMP3_HUMAN (see all proteins):

MMP10 MMP1 MMP12 MMP8 MMP13 MMP27

MMP20 MMP7 MMP2 MMP17 MMP16 MMP24

MMP26 MMP11 MMP14 MMP15 MMP25

MMP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3025080^1,2	C,F,O,H,	--	98634150(-)	`CAAATT/CGCCTT`	1	--	ds500¹		15	NS EA NA WA	1442
rs113379861^1,2		--	98634435(+)	`AAACAG/AACAAA`	1	--	ds500¹		1	CSA	2
rs3025079^1,2	C,F,H,	--	98634626(-)	`TTGCCG/AGTCAT`	1	--	ut3¹		16	NS EA NA CSA WA	1440
rs1892875^1,2	C,F,H,	--	98634645(+)	`TTCACG/ACTCAA`	1	--	ut3¹		18	NS EA NA WA	1724
rs3025078^1,2	C,F	--	98634665(-)	`CGAGTC/TACACT`	1	--	ut3¹ ese³		4	NS NA	90
rs3025077^1,2	C,F,H,	--	98634979(-)	`ataaaC/TACTTT`	1	--	int¹		8	NS EA NA WA	612
rs76822087^1,2		--	98635248(+)	`CACTTG/CCTTGG`	1	--	int¹		1	EA	120
rs676482^1,2	H	--	98635439(-)	`GATTTT/GGTTTT`	1	--	int¹		7	EA NA NS	426
rs3016198^1,2	H	--	98635457(+)	`TTTTTT/AAAACT`	1	--	int¹ trp³		4	NS EA	418
rs3025095^1,2	C,F,H	--	98636333(-)	`GAAAGA/GTGATT`	1	--	int¹		8	NS EA NA	510

HapMap Linkage Disequilibrium report for MMP3 (102706528 - 102714534 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP3: --
Human Gene Mutation Database (HGMD): MMP3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP3

DNA2.0 Custom Variant and Variant Library Synthesis for MMP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP3 for disorders About GeneDecksing

OMIM gene information: 185250 OMIM disorders: --

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:614466]. A

multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of

the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated

with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is

associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity

and higher extracellular matrix deposition in atherosclerotic lesions

20/233 diseases for MMP3 (see all 233): About MalaCards

arthritis recessive dystrophic epidermolysis bullosa superior limbic keratoconjunctivitis alpha 1-antitrypsin deficiency

atherosclerosis epidermolysis bullosa prinzmetal angina adult-onset still's disease

lumbar disc degeneration hyper-ige syndrome sorsby fundus dystrophy encephalomyelitis

mitral valve prolapse frozen shoulder osteochondritis dissecans cleft lip/palate

spinal stenosis bile duct cancer chronic venous leg ulcers coronary heart disease

5 diseases from the University of Copenhagen DISEASES database for MMP3:

Arthritis Vascular disease Synovitis Periodontal disease

Heart disease

10/97 Novoseek disease relationships for MMP3 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	79.1	160	17425385 (6), 11928230 (3), 2057724 (2), 10556259 (2) (see all 87)
osteoarthritis	78.1	54	2057724 (3), 17425385 (3), 11136879 (3), 9128417 (2) (see all 34)
arthritis	65.7	59	12202124 (2), 17703334 (2), 7699637 (2), 11796404 (2) (see all 34)
necrosis	60.9	106	2057724 (3), 8045973 (2), 7921541 (2), 16488289 (2) (see all 76)
tumors	56	225	15466188 (5), 17922906 (3), 15750195 (3), 2057724 (2) (see all 99)
synovitis	54.9	16	17425385 (3), 17918786 (2), 15457463 (2), 11928230 (1) (see all 6)
inflammation	54.5	60	7612046 (2), 10371277 (2), 11084020 (1), 17319946 (1) (see all 45)
conjunctivochalasis	51.7	10	10670469 (5), 10967046 (2), 20019361 (2)
spondylitis ankylosing	48.5	22	15478146 (3), 17156669 (2), 11796404 (2), 18674944 (2) (see all 9)
atherosclerotic plaque	48.3	15	19656094 (1), 19948979 (1), 19542470 (1), 16238676 (1) (see all 10)

Genetic Association Database (GAD): MMP3
Human Genome Epidemiology (HuGE) Navigator: MMP3 (253 documents)

Export disorders for MMP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP3 gene, integrated from 9 sources (see all 1684):
(articles sorted by number of sources associating them with MMP3)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. (PubMed id 12477941)^{1, 2, 4} Yamada Y....Yokota M. (2002)
Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction. (PubMed id 16238676)^{1, 4, 9} Samnegard A....Eriksson P. (2005)
Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study. (PubMed id 12204805)^{1, 4, 9} Pollanen P.J....Karhunen P.J. (2002)
The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China. (PubMed id 15879464)^{1, 4, 9} Shan K....Yan L. (2005)
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. (PubMed id 11977998)^{1, 4, 9} Humphries S....Amouyel P. (2002)
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (PubMed id 15823277)^{1, 4, 9} Pollanen P.J....Karhunen P.J. (2005)
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease. (PubMed id 15955221)^{1, 4, 9} Okamoto K....Yuasa I. (2005)
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer] (PubMed id 16080875)^{1, 4, 9} Li Y....Fang S.M. (2005)
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. (PubMed id 15312099)^{1, 4, 9} Itagaki M....Yamazaki K. (2004)
Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis. (PubMed id 15142265)^{1, 4, 9} Dorr S....Keyszer G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4314	HGNC: 7173	AceView: MMP3	Ensembl:ENSG00000149968	euGenes: HUgn4314
ECgene: MMP3	Kegg: 4314	H-InvDB: MMP3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP3	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/mmp3/

Intellectual Property for MMP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP3 gene:
Search GeneIP for patents involving MMP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Purified and/or Recombinant MMP3 Protein
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MMP3 Gene

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

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Spondylitis Ankylosing
Leg Ulcer
Dementia
Osteoarthritis Knee
Alports Syndrome
Temporomandibular Disorders
Endometriosis
Carcinoma Basal Cell
Bile Duct Cancer
Dermatitis Herpetiformis
Colitis Ulcerative
Polyps
LUNG CARCINOMA
Ischemia
Lymphatic Metastasis
Atherosclerosis
Breast Cancer
Neovascularization
Rheumatic Diseases
Keratoconus
Asthma
disability
Cancer
Obstruction
premalignant
Aneurysm
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virus infection
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Diabetes Mellitus
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Epidermolysis Bullosa Dystrophic
Aortic Aneurysm Abdominal
Heart Diseases
NASOPHARYNGEAL CARCINOMA
Breakthrough Bleeding
Chronic periodontitis
OBESITY
Carcinoma Squamous Cell
Gingival Overgrowth
stromal tumors
Sclerosis Systemic
BONE DESTRUCTION
Synovitis
Lupus Erythematosus Systemic
Arthritis
Renal Failure Chronic

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MMP3 Gene

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

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