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MMP3 Gene

protein-coding   GIFtS: 75
GCID: GC11M102706

Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase)

(Previous names: matrix metalloproteinase 3 (stromelysin 1, progelatinase))
(Previous symbols: STMY1, STMY)
  See MMP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase)1 2     CHDS62 5
STMY11 2 3 5     STR12
STMY1 2     proteoglycanase2
Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase)1 2     stromelysin-12
Matrix Metalloproteinase-32 3     transin-12
MMP-32 3     Transin-13
SL-12 3     EC 3.4.248
EC 3.4.24.173 8     

External Ids:    HGNC: 71731   Entrez Gene: 43142   Ensembl: ENSG000001499687   OMIM: 1852505   UniProtKB: P082543   

Export aliases for MMP3 gene to outside databases

Previous GC identifers: GC11M104900 GC11M104063 GC11M102695 GC11M102199 GC11M102200 GC11M102211 GC11M098634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP3 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin,
laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound
repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which
localize to chromosome 11q22.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP3 Gene:
MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase)) is a protein-coding gene. Diseases associated with MMP3 include conjunctivochalasis, and superior limbic keratoconjunctivitis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254
Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and
cartilage proteoglycans. Activates procollagenase

summary for MMP3 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP3 gene promoter:
         SRF   Sox5   AP-1   SRF (504 AA)   HNF-1A   SRY   HNF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP3 promoter sequence
   Search Chromatin IP Primers for MMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22.3

MMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102706:  view genomic region     (about GC identifiers)

Start:
102,706,528 bp from pter      End:
102,714,534 bp from pter
Size:
8,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254 (See protein sequence)
Recommended Name: Stromelysin-1 precursor  
Size: 477 amino acids; 53977 Da
Cofactor: Binds 4 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Selected PDB 3D structures from and Proteopedia for MMP3 (see all 41):
1B3D (3D)        1B8Y (3D)        1BIW (3D)        1BM6 (3D)        1BQO (3D)        1C3I (3D)    
Secondary accessions: B2R8B8 Q3B7S0 Q6GRF8

Explore the universe of human proteins at neXtProt for MMP3: NX_P08254

Explore proteomics data for MMP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP3 (P08254) (see all 13)
     HSLGLFH  GEADIMI  FWRKSLR  GIQSLYG 


    See MMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002413.1  
    ENSEMBL proteins: 
     ENSP00000299855   ENSP00000398346   ENSP00000435255  
    Reactome Protein details: P08254

    MMP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP3 (MMP-3)
    Enzo Life Sciences proteins for MMP3
    OriGene Purified Proteins for MMP3
    OriGene Protein Over-expression Lysate for MMP3
    OriGene MassSpec for MMP3
    OriGene Custom Protein Services for MMP3
    GenScript Custom Purified and Recombinant Proteins Services for MMP3
    Novus Biologicals MMP3 Proteins
    Novus Biologicals MMP3 Lysates
    Sino Biological Recombinant Protein for MMP3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MMP3
    Cloud-Clone Corp. Proteins for MMP3

     
    Search eBioscience for Proteins for MMP3 

    MMP3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP3
    R&D Systems Antibodies for MMP3 (MMP-3)
    OriGene Antibodies for MMP3
    OriGene Custom Antibody Services for MMP3
    Novus Biologicals MMP3 Antibodies
    Abcam antibodies for MMP3
    Cloud-Clone Corp. Antibodies for MMP3
    ThermoFisher Antibody for MMP3
    LSBio Antibodies in human, mouse, rat for MMP3

    MMP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP3
    R&D Systems ELISAs for MMP3 (MMP-3)         (see all)
    GenScript MMP3-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP3
    Cloud-Clone Corp. ELISAs for MMP3
    Cloud-Clone Corp. CLIAs for MMP3
    eBioscience ELISAs for MMP3:  
                        Human MMP-3 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP3
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P08254

    ProtoNet protein and cluster: P08254

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP3_HUMAN, P08254
    Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and
    cartilage proteoglycans. Activates procollagenase
    Catalytic activity: Preferential cleavage where P1', P2' and P3' are hydrophobic residues

         Genatlas biochemistry entry for MMP3:
    matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing
    bone,interacting with ZBP89,playing a role in tumor metastasis

         Enzyme Numbers (IUBMB): EC 3.4.24.171 2 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MMP3:
     Decreased circadian period len  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp3):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  skeleton 

    Find genes that share phenotypes with MMP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmp3tm1Mrl for MMP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP3:
    hsa-mir-138-5p (MIRT021683)

    Block miRNA regulation of human, mouse, rat MMP3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP3:
    hsa-miR-146b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP3
    Predesigned siRNA for gene silencing in human, mouse, rat MMP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP3

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP3 (see all 6)
    OriGene ORF clones in mouse, rat for MMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP3 (NM_002422)
    Sino Biological Human cDNA Clone for MMP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP3_HUMAN, P08254: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton2
    endoplasmic reticulum2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS3360803
    GO:0031012extracellular matrix ----
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with MMP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP3 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with MMP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP3
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    3 GeneGo (Thomson Reuters) Pathways for MMP3
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via MAPK in human cells

    3 BioSystems Pathways for MMP3
        Matrix Metalloproteinases
    Oncostatin M Signaling Pathway
    p75(NTR)-mediated signaling


    5 Reactome Pathways for MMP3
        Assembly of collagen fibrils and other multimeric structures
    EGFR Transactivation by Gastrin
    Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases


    3 Kegg Pathways  (Kegg details for MMP3):
        TNF signaling pathway
    Transcriptional misregulation in cancer
    Rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP3 (see all 7): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Th17 Response in human mouse rat
              Atherosclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MMP3 (P082542, 3 ENSP000002998554) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPOCK3Q9BQ163, ENSP000003501534I2D: score=2 STRING: ENSP00000350153
    CCL2P135003, ENSP000002258314I2D: score=1 STRING: ENSP00000225831
    CCL7P800983, ENSP000002003074I2D: score=1 STRING: ENSP00000200307
    DCNP075853, ENSP000000527544I2D: score=1 STRING: ENSP00000052754
    HAPLN1P109153, ENSP000002743414I2D: score=1 STRING: ENSP00000274341
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS3360803
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030334regulation of cell migration IEA--
    GO:0030574collagen catabolic process TAS--

    Find genes that share ontologies with MMP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP3
    Selected ApexBio Compounds for MMP3 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    2 HMDB Compounds for MMP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected DrugBank Compounds for MMP3 (see all 22)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide-- --target--17139284 17016423 10592235
    5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione-- --target--17139284 17016423 10592235
    A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor-- --target--17139284 17016423 10592235
    N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide-- --target--17139284 17016423 10592235
    N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide-- --target--17139284 17016423 10592235
    R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid-- --target--17139284 17016423 10592235
    (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine-- --target--17139284 17016423
    1-Methyloxy-4-Sulfone-Benzene-- --target--17139284 17016423
    3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid-- --target--17139284 17016423
    3-Methylpyridine-- 108-99-6target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for MMP3 gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 84.3 20 2383557 (3), 8195131 (1), 9930993 (1), 2176865 (1) (see all 10)
    n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid 76.8 6 12841876 (1), 19834065 (1), 15814801 (1)
    ilomastat 68.3 1 14611841 (1)
    hydroxamate 56.2 7 16603129 (2), 18029177 (1), 10521266 (1)
    pge2 48 87 15948687 (6), 14981131 (4), 17214881 (4), 19835666 (4) (see all 30)
    matrigel 47.7 6 11419692 (4), 12379519 (1), 20188714 (1)
    infliximab 46.7 29 17156669 (4), 17552048 (2), 19357521 (2), 15478146 (2) (see all 15)
    vegf 43.5 94 15571312 (6), 15455259 (5), 18363112 (5), 11308991 (4) (see all 41)
    latanoprost 42.2 13 11027004 (4), 14638715 (2), 18971237 (2), 16505029 (2) (see all 6)
    keratan sulfate 40.9 6 9920023 (1), 14613270 (1), 12202124 (1), 7719956 (1)

    3 PharmGKB related drug/compound annotations for MMP3 gene    About this table
    Drug/compound PharmGKB Annotation
    chlorthalidoneCA  
    lisinoprilCA  
    pravastatinCA  



    Find genes that share compounds with MMP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP3 gene: 
    NM_002422.3  

    Unigene Cluster for MMP3:

    Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    Hs.375129  [show with all ESTs]
    Unigene Representative Sequence: AK223291
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299855(uc001phj.1) ENST00000434103 ENST00000524478
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MMP3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP3:
    hsa-miR-146b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MMP3
    Predesigned siRNA for gene silencing in human, mouse, rat MMP3
    Clone
    Products:
         
    OriGene clones in human, mouse for MMP3 (see all 6)
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    Additional mRNA sequence: 

    AK223283.1 AK223291.1 AK313310.1 BC069676.1 BC069716.1 BC074815.2 BC074869.2 BC105954.1 
    BC107490.1 BC107491.1 DQ399598.1 J03209.1 X05232.1 

    10 DOTS entries:

    DT.313463  DT.99997921  DT.120702923  DT.99940879  DT.100035204  DT.100651118  DT.120702977  DT.120702989 
    DT.99999491  DT.106379 

    Selected AceView cDNA sequences (see all 209):

    AA535129 BM991379 BM988940 BQ771783 BC074815 BU623701 CD614797 CN479902 
    AW291450 CA412479 BQ182789 CA414582 CD365864 BQ181107 BQ019029 CF132244 
    C02073 CF126566 CA413861 CA430963 BP344724 AI281285 BP344327 BP344623 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCAGGCT
    MMP3 Expression
    About this image


    MMP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Adipose (Muscoskeletal System)
             Stromal Vascular Preadipocyte Progenitor Cells Vascular Adipose
     
     Fibroblasts (Uncategorized)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Detroit 551
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    MMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375129
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP3 (see all 7): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Th17 Response in human mouse rat
              Atherosclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp31 , 5 matrix metallopeptidase 31, 5 81.9(n)1
    77.15(a)1
      9 (2.46 cM)5
    173921  NM_010809.11  NP_034939.11 
     74458225 
    chicken
    (Gallus gallus)
    Aves LOC4280861 stromelysin-1-like 62.37(n)
    53.7(a)
      428086  XM_425644.4  XP_425644.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    51(a)
    many ↔ many
    many ↔ many
    3(192100483-192115896)
    3(192049389-192058962)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF218175.12   -- 71.85(n)    CF218175.1 


    ENSEMBL Gene Tree for MMP3 (if available)
    TreeFam Gene Tree for MMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP3 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP112  MMP272  MMP172  MMP102  MMP12  
    17 SIMAP similar genes for MMP3 using alignment to 4 protein entries:     MMP3_HUMAN (see all proteins):
    MMP10    MMP1    MMP12    MMP8    MMP13    MMP27
    MMP20    MMP7    MMP2    MMP17    MMP16    MMP24
    MMP26    MMP11    MMP14    MMP15    MMP25

    Find genes that share paralogs with MMP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP3 (see all 295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138237481,2
    F--98641056(-) AAAAAA/GMAAAA 1 -- int11Minor allele frequency- G:0.19PA 120
    rs1999885791,2
    F--98641081(+) TTTTTT/AACCTC 1 -- int11Minor allele frequency- A:0.00EU 593
    rs1143596701,2
    F--102575550(+) GATACA/GAAATG 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1470986561,2
    --102575612(+) CTTGCC/TAGGTC 1 -- ds50010--------
    rs30250801,2
    C,F,O,H--102575717(-) CAAATT/CGCCTT 1 -- ds500115Minor allele frequency- C:0.02NS EA NA WA 1442
    rs1133798611,2
    F--102576002(+) AAACAG/AACAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1874142241,2
    --102576109(+) TCCCCC/TTCTCT 1 -- ut310--------
    rs1889179211,2
    C--102576110(+) CCCCTG/TCTCTT 1 -- ut310--------
    rs1401460801,2
    --102576175(+) GCCCTA/GTAATA 1 -- ut310--------
    rs30250791,2
    C,F,H--102576194(-) TTGCCG/AGTCAT 1 -- ut3116Minor allele frequency- A:0.05NS EA NA CSA WA 1440

    HapMap Linkage Disequilibrium report for MMP3 (102706528 - 102714534 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MMP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663139CNV Deletion23128226
    nsv898336CNV Loss21882294
    nsv898335CNV Loss21882294

    Human Gene Mutation Database (HGMD): MMP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185250   
    OMIM disorders: 614466  
    UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254
  • Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance
    between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood
    flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of
    the coronary arteries. Note=Disease susceptibility is associated with variations affecting the gene represented
    in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease
    and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in
    atherosclerotic lesions

  • Selected diseases for MMP3 (see all 26):    
    About MalaCards
    conjunctivochalasis    superior limbic keratoconjunctivitis    gingival hypertrophy    coronary heart disease 6
    arthritis    fundus dystrophy    corneal ulcer    spondylarthropathy
    corneal edema    frozen shoulder    spondylolisthesis    dermatitis herpetiformis
    takayasu's arteritis    tendinosis    lumbar disc herniation    exfoliation syndrome
    intervertebral disc disease    atherosclerosis    spondylitis    recessive dystrophic epidermolysis bullosa

    5 diseases from the University of Copenhagen DISEASES database for MMP3:
    Arthritis     Vascular disease     Synovitis     Periodontal disease
    Heart disease

    Find genes that share disorders with MMP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MMP3 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 79.1 160 17425385 (6), 11928230 (3), 2057724 (2), 10556259 (2) (see all 87)
    osteoarthritis 78.1 54 2057724 (3), 17425385 (3), 11136879 (3), 9128417 (2) (see all 34)
    arthritis 65.7 59 12202124 (2), 17703334 (2), 7699637 (2), 11796404 (2) (see all 34)
    necrosis 60.9 106 2057724 (3), 8045973 (2), 7921541 (2), 16488289 (2) (see all 76)
    tumors 56 225 15466188 (5), 17922906 (3), 15750195 (3), 2057724 (2) (see all 99)
    synovitis 54.9 16 17425385 (3), 17918786 (2), 15457463 (2), 11928230 (1) (see all 6)
    inflammation 54.5 60 7612046 (2), 10371277 (2), 11084020 (1), 17319946 (1) (see all 45)
    conjunctivochalasis 51.7 10 10670469 (5), 10967046 (2), 20019361 (2)
    spondylitis ankylosing 48.5 22 15478146 (3), 17156669 (2), 11796404 (2), 18674944 (2) (see all 9)
    atherosclerotic plaque 48.3 15 19656094 (1), 19948979 (1), 19542470 (1), 16238676 (1) (see all 10)

    Genetic Association Database (GAD): MMP3
    Human Genome Epidemiology (HuGE) Navigator: MMP3 (253 documents)

    Export disorders for MMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP3 gene, integrated from 10 sources (see all 1724):
    (articles sorted by number of sources associating them with MMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. (PubMed id 12477941)1, 2, 4 Yamada Y.... Yokota M. (N. Engl. J. Med. 2002)
    2. No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese. (PubMed id 16937230)1, 4, 9 Xu E....Huang Q. (Dis. Colon Rectum 2006)
    3. [Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]. (PubMed id 19065524)1, 4, 9 Huang X....Ye Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    4. Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children. (PubMed id 18810583)1, 4, 9 Hong Y.M....Hong S.J. (Heart Vessels 2008)
    5. Haplotype analysis of the stromelysin-1 (MMP3) and gelatinase B (MMP9) genes in relation to coronary heart disease. (PubMed id 19438845)1, 4, 9 Wu N....Yang Y. (Ann. Hum. Genet. 2009)
    6. Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients. (PubMed id 18077489)1, 4, 9 Tsukahara S....Momohara S. (Rheumatology (Oxford) 2008)
    7. An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms. (PubMed id 17875574)1, 4, 9 Deguara J....Smith A. (Hum. Mol. Genet. 2007)
    8. Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction. (PubMed id 16238676)1, 4, 9 SamnegAYrd A....Eriksson P. (J. Intern. Med. 2005)
    9. Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study. (PubMed id 12204805)1, 4, 9 PAPllAonen P.J....Karhunen P.J. (Atherosclerosis 2002)
    10. Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. (PubMed id 19376102)1, 4, 9 Chen Q.J....Shen W.F. ( international journal of clinical chemistry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4314 HGNC: 7173 AceView: MMP3 Ensembl:ENSG00000149968 euGenes: HUgn4314
    ECgene: MMP3 Kegg: 4314 H-InvDB: MMP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP3 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/mmp3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP3 gene:
    Search GeneIP for patents involving MMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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