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MMP3 Gene

protein-coding GIFtS: 72

GC11M102211

matrix metallopeptidase 3 (stromelysin 1, progelatinase)
(Previous names: matrix metalloproteinase 3 (stromelysin 1, progelatinase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: STMY1, STMY)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHDS6 ^², ⁵
EC 3.4.24.17 ^³
MGC126102 ^²
MGC126103 ^²
MGC126104 ^²
MMP-3 ^², ³
SL-1 ^², ³
STMY ^²
STMY1 ^², ³, ⁵
STR1 ^²
Transin-1 ^³
proteoglycanase ^²
transin-1 ^²

Descriptions
Matrix metalloproteinase-3 ^³
matrix metallopeptidase 3 (stromelysin 1, progelatinase) ^²
matrix metalloproteinase 3 ^²
matrix metalloproteinase 3 (stromelysin 1, progelatinase) ^¹, ²

External Ids
HGNC: 7173¹
Entrez Gene: 4314²
UniProtKB: P08254³
Ensembl: ENSG00000149968⁷

Search outside databases for aliases for MMP3 gene

Previous GC identifers: GC11M104900 GC11M104063 GC11M102695 GC11M102199 GC11M102200

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MMP3:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of

extracellular matrix in normal physiological processes, such as embryonic development,

reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and

metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved

by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin,

collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in

wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster

of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV,

X, and IX, and cartilage proteoglycans. Activates procollagenase

Gene Wiki entry for MMP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MMP3 gene

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3

MMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102211: (about GC identifiers)

Start:	102,211,738 bp from pter
End:	102,219,552 bp from pter
Size:	7,815 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254 (See protein sequence)

Recommended Name: Stromelysin-1 precursor

Size: 477 amino acids; 53977 Da

Cofactor: Binds 4 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

PDB structures from and Proteopedia :

1B3D (3D)

1B8Y (3D)

1BIW (3D)

1BM6 (3D)

1BQO (3D)

1C3I (3D)

1C8T (3D)

1CAQ (3D)

1CIZ (3D)

1CQR (3D)

1D5J (3D)

1D7X (3D)

1D8F (3D)

1D8M (3D)

1G05 (3D)

1G49 (3D)

1G4K (3D)

1HFS (3D)

1HY7 (3D)

1M1W (3D)

1OO9 (3D)

1QIA (3D)

1QIC (3D)

1SLM (3D)

1SLN (3D)

1UEA (3D)

1UMS (3D)

1UMT (3D)

1USN (3D)

2D1O (3D)

2JNP (3D)

2JT5 (3D)

2JT6 (3D)

2SRT (3D)

2USN (3D)

3USN (3D)

Secondary accessions: Q3B7S0 Q6GRF8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002413.1

ENSEMBL proteins:

ENSP00000299855

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MMP3 Protein
	Sigma-Aldrich AQUA Peptides for MMP3
	R&D Systems Recombinant & Natural Proteins for MMP3 (MMP-3)
	Enzo Life Sciences proteins for MMP3
	Recombinant Proteins from Abcam (MMP3)
	Human Recombinant Proteins from Abnova (MMP3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	3360803
GO:0043231	intracellular membrane-bounded organelle	IDA	18029348

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Antibodies for MMP3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MMP3
	Sigma-Aldrich Antibodies for MMP3
	R&D Systems Antibodies for MMP3 (MMP-3)
	Antibodies from Abcam (MMP3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for MMP3

Assays for MMP3:

	Invitrogen Assays for MMP3
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for MMP3 (MMP-3) (see all)
	Enzo Life Sciences assays for MMP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08254

ProtoNet protein and cluster: P08254

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002422

Applied Biosystems Silencer® siRNAs for MMP3

Sigma-Aldrich siRNA and siRNA Panels for MMP3

Sigma-Aldrich shRNA Panels and shRNA for MMP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MMP3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002422
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002422
untagged cDNA clone in CMV expression vector: NM_002422

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002422

UniProtKB/Swiss-Prot: MMP3_HUMAN, P08254

Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV,

X, and IX, and cartilage proteoglycans. Activates procollagenase

Catalytic activity: Preferential cleavage where P1', P2' and P3' are hydrophobic residues

Enzyme Number (IUBMB): EC 3.4.24.17

Genatlas biochemistry entry for MMP3:

matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the

developing bone,interacting with ZBP89,playing a role in tumor metastasis

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp3):

homeostasis/metabolism

immune system

nervous system

skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	3360803
GO:0005509	calcium ion binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for MMP3 (Your Favorite Gene powered by Ingenuity)

Oncostatin M Signaling
Leukocyte Extravasation Signaling
IL-17 Signaling
HIF1&alpha
Bladder Cancer Signaling

GeneDecks MMP3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MMP3

5/92 Interacting proteins for MMP3 (P08254² ENSP00000299855³) via UniProtKB, MINT, and/or STRING (see all 92 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIMP1	ENSP00000218388³	STRING (score=.999)
CCL2	ENSP00000225831³	STRING (score=.982)
COL1A1	ENSP00000225964³	STRING (score=.977)
IL1B	ENSP00000263341³	STRING (score=.975)
TBP	ENSP00000230354³	STRING (score=.975)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	3360803
GO:0008152	metabolic process	IEA	--
GO:0030574	collagen catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MMP3

Sigma-Aldrich Small Molecules for MMP3:

Inhibitor

Compounds for MMP3 available from Tocris Bioscience

Compound	Action	CAS number
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]
UK 370106	Highly selective MMP-3 and MMP-12 inhibitor	[230961-21-4]

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10/49 Novoseek chemical compound relationships for MMP3 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate	84.88	20	2383557 (3), 8195131 (1), 9930993 (1), 2176865 (1) (see all 10)
n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid	73.64	5	12841876 (1), 15814801 (1)
hydroxamate	57.87	7	16603129 (2), 18029177 (1), 10521266 (1)
matrigel	48.03	5	11419692 (4), 12379519 (1)
1,10-phenanthroline	42.76	2	8045973 (1), 2071592 (1)
keratan sulfate	42.36	6	9920023 (1), 14613270 (1), 12202124 (1), 7719956 (1)
rantes	36.00	10	16468043 (2), 18082490 (1), 19007749 (1), 18080321 (1) (see all 8)
glycosaminoglycan	34.01	6	11518264 (2), 17436000 (1), 11817583 (1), 10895897 (1) (see all 5)
zinc	32.13	16	8399171 (1), 15703331 (1), 7656014 (1), 1581308 (1) (see all 13)
butaprost	29.64	3	14981131 (1), 15948687 (1)

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1 PharmGKB drug compound relationship for MMP3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
pravastatin	CO PD	10190398

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002422

Sigma-Aldrich siRNA and siRNA Panels for MMP3

Sigma-Aldrich shRNA Panels and shRNA for MMP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002422

REFSEQ mRNAs for MMP3 gene:

NM_002422.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002422

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002422
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002422
                                 untagged cDNA clone in CMV expression vector: NM_002422

Additional cDNA sequence:

AK223283.1 AK223291.1 AK313310.1 BC069676.1 BC069716.1 BC074815.2 BC074869.2 BC105954.1

BC107490.1 BC107491.1 DQ399598.1 J03209.1 X05232.1

10 DOTS entries:

DT.313463 DT.120702923 DT.99997921 DT.99940879 DT.100035204 DT.100651118 DT.120702977 DT.120702989

DT.99999491 DT.106379

24/209 AceView cDNA sequences (see all 209 ):

BQ019029 BC074815 CN479902 BQ181107 AA535129 BM991379 BQ771783 CF132244

C02073 CD365864 CA412479 CA414582 BM988940 CA430963 AW291450 CA413861

CD614797 BQ182789 CF126566 BU623701 BP344404 BG927137 BG929172 BG925679

highest scoring ESTs for MMP3:

X05232 AA062793 AA853659 AU279682 BC069676 BC069716 BE439639 BE440042 BG897173 BI830129

Unigene Cluster for MMP3:

Matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Hs.375129 [show with all ESTs]

Unigene Representative Sequence: AK223291

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000299855

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MMP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MMP3

¹ / ² / ³

3 probe-sets matching MMP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
437_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X05232	1.00	1.00	1.00	1
205828_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002422	0.60	1.00	0.82	1
205828_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGCCAGGCT

SOURCE GeneReport for Unigene cluster: Hs.375129
Expression variation in blood from EXPOLDB for MMP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MMP3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MMP3¹	--	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	84.56(n) 80.92(a)	403445 NM_001002967.1 NP_001002967.1
chimpanzee (Pan troglodytes)	MMP3¹	--	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	98.67(n) 98.74(a)	451511 XM_508723.2 XP_508723.2
cow (Bos taurus)	MMP3¹	--	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	84(n) 83.02(a)	281309 XM_586521.2 XP_586521.2
rat (Rattus norvegicus)	Mmp3¹	--	matrix metallopeptidase 3	81.19(n) 75.37(a)	171045 NM_133523.1 NP_598207.1
mouse (Mus musculus)	Mmp3^{1, 5}	9 (1.00 cM)⁵	matrix metallopeptidase 3^{1, 5}	81.9(n)¹ 77.15(a)¹	17392¹ NM_010809.1¹ NP_034939.1¹ AK148467⁵ AY622967⁵ (see all 9)

About this table Species with no ortholog for MMP3

ENSEMBL Gene Tree for MMP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MMP3 gene

MMP27² MMP8² MMP10² MMP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/83 NCBI SNPs in MMP3 are shown (see all 83 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs522616^1,2	A,C,F,H,O	102220258(-)	`TTTCAA/GTTCTA`	1	--	ng3¹		30	EA NA NS MN EU WA	2662
	rs679620^1,2	A,C,F,H	102218830(-)	`ACCTCG/AAAAAA`	1	E/K	mis¹ ese³		26	EA NS MN NA EU WA	3734
	rs3025080^1,2	C,F,H,O	102211438(-)	`CAAATT/CGCCTT`	1	--	ng5¹		9	NS EU EA WA NA	650
	rs645419^1,2	A,C,F,H	102221531(+)	`CCCTGG/AAAGAT`	1	--	ng3¹		7	NS EA EU WA	1944
--	rs632478^1,2	A,C,F,O	102220891(-)	`TATCAA/CCTGTG`	1	--	ng3¹		5	NS NA	230
	rs3025090^1,2	C,F,H	102220093(-)	`TCCAAC/TGACAG`	1	--	ng3¹		8	NS EU EA WA NA	594
	rs3025079^1,2	C,F,H	102211914(-)	`TTGCCG/AGTCAT`	1	--	ut3¹		9	NS EU EA WA NA	648
	rs617819^1,2	A,C,F	102219926(-)	`AATGTC/GTTTCT`	1	--	ng3¹		6	NS MN EA NA	546
	rs1892875^1,2	C,F,H	102211933(+)	`TTCACG/ACTCAA`	1	--	ut3¹		10	EU EA WA NS NA	696
	rs3025060^1,2	F,H	102219883(-)	`ATTCTG/AATTTT`	1	--	ng3¹		6	NS EU EA WA	512

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HapMap Linkage Disequilibrium images for MMP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 185250

10/97 Novoseek disease relationships for MMP3 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	78.23	152	17425385 (6), 11928230 (3), 2057724 (2), 7612046 (2) (see all 84)
osteoarthritis	77.81	49	2057724 (3), 17425385 (3), 11136879 (3), 9128417 (2) (see all 31)
arthritis	63.77	43	12202124 (2), 17703334 (2), 7699637 (2), 11796404 (2) (see all 26)
necrosis	59.76	101	2057724 (3), 8045973 (2), 7921541 (2), 16488289 (2) (see all 73)
tumors	55.38	212	15466188 (5), 17922906 (3), 15750195 (3), 2057724 (2) (see all 99)
inflammation	52.51	55	7612046 (2), 10371277 (2), 11084020 (1), 17319946 (1) (see all 40)
inflammatory joint disease	49.00	1	9918244 (1)
traumatic arthritis	48.99	3	10752493 (1), 7732485 (1)
atherosclerotic plaque	47.78	10	16238676 (1), 9763539 (1), 12821236 (1), 15823277 (1) (see all 6)
synovitis	47.09	16	17425385 (3), 17918786 (2), 15457463 (2), 11928230 (1) (see all 6)

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1 PharmGKB disease relationship for MMP3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Coronary Arteriosclerosis	CO PD	10190398

About this table

Human Gene Mutation Database: MMP3
Genetic Association Database: MMP3
Human Genome Epidemiology Navigator: MMP3 (163 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1353 PubMed articles for MMP3 gene (see all 1353 ):

Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction. (PubMed id 16238676)^{1, 3, 6} Samnegard A....Eriksson P. (2005)
Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study. (PubMed id 12204805)^{1, 3, 6} Pollanen P.J....Karhunen P.J. (2002)
The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China. (PubMed id 15879464)^{1, 3, 6} Shan K....Yan L. (2005)
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. (PubMed id 11977998)^{1, 3, 6} Humphries S....Amouyel P. (2002)
The promoter polymorphism of the matrix metalloproteinase 3 (MMP-3) gene in women with ovarian cancer. (PubMed id 12385578)^{1, 3, 6} Szyllo K....Kulig A. (2002)
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4- aminophenyl)mercuric acetate. (PubMed id 2383557)^{1, 3, 4} Nagase H.... Salvesen G. (1990)
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (PubMed id 15823277)^{1, 3, 6} Pollanen P.J....Karhunen P.J. (2005)
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease. (PubMed id 15955221)^{1, 3, 6} Okamoto K....Yuasa I. (2005)
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer] (PubMed id 16080875)^{1, 3, 6} Li Y....Fang S.M. (2005)
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. (PubMed id 15312099)^{1, 3, 6} Itagaki M....Yamazaki K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4314	HGNC: 7173	AceView: MMP3	Ensembl:ENSG00000149968	euGenes: HUgn4314
ECgene: MMP3	H-InvDB: MMP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MMP3	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/mmp3/

Licensable Technologies for MMP3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MMP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MMP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MMP3		Antibodies for MMP3
	Explore super-pooled esiRNAs		Proteins for MMP3
	Lentivirus-delivered shRNAs for MMP3		Small molecules for MMP3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MMP3)
	Search for Antibodies
	Chimera RNAi (MMP3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MMP3)
	Antibodies (MMP3)

Search OriGene for MMP3

Tocris compounds for MMP3

	Assays/Drugs/Proteins for MMP3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MMP3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MMP3 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

MMP3 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for MMP3

Summaries
for MMP3

Genomic Location
for MMP3

Proteins
for MMP3

Protein Domains/
Families
for MMP3

Gene Function
for MMP3

Pathways & Interactions
for MMP3

Drugs & Compounds
for MMP3

Transcripts
for MMP3

Expression
for MMP3

Orthologs
for MMP3

Paralogs
for MMP3

SNPs/Variants
for MMP3

Disorders & Mutations
for MMP3

Medical News
for MMP3

Publications
for MMP3

Search for MMP3

Genome Databases showing MMP3

Other Databases showing MMP3

Specialized Databases showing MMP3

Licensable Technologies
for MMP3

Services
for MMP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MMP3 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor MMP3

Summariesfor MMP3

Genomic Locationfor MMP3

Proteinsfor MMP3

Protein Domains/Familiesfor MMP3

Gene Functionfor MMP3

Pathways & Interactionsfor MMP3

Drugs & Compoundsfor MMP3

Transcriptsfor MMP3

Expression for MMP3

Orthologsfor MMP3

Paralogsfor MMP3

SNPs/Variantsfor MMP3

Disorders & Mutationsfor MMP3

Medical Newsfor MMP3

Publicationsfor MMP3

Search for MMP3

Genome Databases showing MMP3

Other Databases showing MMP3

Specialized Databases showing MMP3

Licensable Technologiesfor MMP3

Servicesfor MMP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MMP3

Summaries
for MMP3

Genomic Location
for MMP3

Proteins
for MMP3

Protein Domains/
Families
for MMP3

Gene Function
for MMP3

Pathways & Interactions
for MMP3

Drugs & Compounds
for MMP3

Transcripts
for MMP3

Expression
for MMP3

Orthologs
for MMP3

Paralogs
for MMP3

SNPs/Variants
for MMP3

Disorders & Mutations
for MMP3

Medical News
for MMP3

Publications
for MMP3

Licensable Technologies
for MMP3

Services
for MMP3