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Aliases for MMP3 Gene

Aliases for MMP3 Gene

  • Matrix Metallopeptidase 3 2 3 5
  • Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase) 2 3
  • EC 3.4.24.17 4 63
  • Transin-1 3 4
  • STMY1 3 4
  • MMP-3 3 4
  • SL-1 3 4
  • Matrix Metalloproteinase-3 4
  • Proteoglycanase 3
  • Stromelysin 1 2
  • EC 3.4.24 63
  • CHDS6 3
  • STR1 3
  • STMY 3

External Ids for MMP3 Gene

Previous HGNC Symbols for MMP3 Gene

  • STMY1
  • STMY

Previous GeneCards Identifiers for MMP3 Gene

  • GC11M104900
  • GC11M104063
  • GC11M102695
  • GC11M102199
  • GC11M102200
  • GC11M102211
  • GC11M102706
  • GC11M098634

Summaries for MMP3 Gene

Entrez Gene Summary for MMP3 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP3 Gene

MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include coronary heart disease 6 and arthritis. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP3 Gene

  • Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Tocris Summary for MMP3 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP3 Gene

Genomics for MMP3 Gene

Regulatory Elements for MMP3 Gene

Genomic Location for MMP3 Gene

Chromosome:
11
Start:
102,835,797 bp from pter
End:
102,843,803 bp from pter
Size:
8,007 bases
Orientation:
Minus strand

Genomic View for MMP3 Gene

Genes around MMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP3 Gene

Proteins for MMP3 Gene

  • Protein details for MMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08254-MMP3_HUMAN
    Recommended name:
    Stromelysin-1
    Protein Accession:
    P08254
    Secondary Accessions:
    • B2R8B8
    • Q3B7S0
    • Q6GRF8

    Protein attributes for MMP3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP3 Gene

neXtProt entry for MMP3 Gene

Proteomics data for MMP3 Gene at MOPED

Post-translational modifications for MMP3 Gene

  • Glycosylation at Asn 120
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP3 (MMP3)

Domains & Families for MMP3 Gene

Gene Families for MMP3 Gene

Suggested Antigen Peptide Sequences for MMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08254

UniProtKB/Swiss-Prot:

MMP3_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP3: view

Function for MMP3 Gene

Molecular function for MMP3 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing bone,interacting with ZBP89,playing a role in tumor metastasis
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage where P1, P2 and P3 are hydrophobic residues.
UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP3 Gene

Gene Ontology (GO) - Molecular Function for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP3: view
genes like me logo Genes that share phenotypes with MMP3: view

Animal Models for MMP3 Gene

MGI Knock Outs for MMP3:

Animal Model Products

miRNA for MMP3 Gene

miRTarBase miRNAs that target MMP3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP3 Gene

Localization for MMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP3 Gene COMPARTMENTS Subcellular localization image for MMP3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MMP3 Gene

Pathways & Interactions for MMP3 Gene

genes like me logo Genes that share pathways with MMP3: view

SIGNOR curated interactions for MMP3 Gene

Activates:

Gene Ontology (GO) - Biological Process for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010727 negative regulation of hydrogen peroxide metabolic process IDA 20969476
GO:0022617 extracellular matrix disassembly TAS --
GO:0032461 positive regulation of protein oligomerization IDA 19022250
GO:1903209 positive regulation of oxidative stress-induced cell death ISS --
genes like me logo Genes that share ontologies with MMP3: view

Drugs & Compounds for MMP3 Gene

(95) Drugs for MMP3 Gene - From: Novoseek, DrugBank, DGIdb, PharmGKB, HMDB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor, Target, antagonist MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
Pravastatin Approved Pharma Competitive, Inhibitor 144
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 493
Chlorthalidone Approved Pharma 57
Lisinopril Approved, Investigational Pharma ACE inhibitor 116

(57) Additional Compounds for MMP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP3: view

Drug Products

Transcripts for MMP3 Gene

mRNA/cDNA for MMP3 Gene

Unigene Clusters for MMP3 Gene

Matrix metallopeptidase 3 (stromelysin 1, progelatinase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP3 Gene

No ASD Table

Relevant External Links for MMP3 Gene

GeneLoc Exon Structure for
MMP3
ECgene alternative splicing isoforms for
MMP3

Expression for MMP3 Gene

mRNA expression in normal human tissues for MMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP3 Gene

This gene is overexpressed in Minor Salivary Gland (x29.0), Adipose - Subcutaneous (x6.7), and Nerve - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for MMP3 Gene

This gene is overexpressed in Synovial fluid (55.5) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP3 Gene



SOURCE GeneReport for Unigene cluster for MMP3 Gene Hs.375129

genes like me logo Genes that share expression patterns with MMP3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MMP3 Gene

Orthologs for MMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP3 35
  • 98.67 (n)
  • 98.74 (a)
MMP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP3 36
  • 50 (a)
OneToOne
MMP3 35
  • 84 (n)
  • 83.02 (a)
dog
(Canis familiaris)
Mammalia MMP3 35
  • 84.56 (n)
  • 80.92 (a)
MMP3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp3 35
  • 81.9 (n)
  • 77.15 (a)
Mmp3 16
Mmp3 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mmp3 35
  • 81.4 (n)
  • 75.79 (a)
chicken
(Gallus gallus)
Aves LOC428086 35
  • 62.37 (n)
  • 53.7 (a)
-- 36
  • 53 (a)
ManyToMany
MMP10 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489571 35
  • 59.64 (n)
  • 54.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 44 (a)
Species with no ortholog for MMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP3 Gene

ENSEMBL:
Gene Tree for MMP3 (if available)
TreeFam:
Gene Tree for MMP3 (if available)

Paralogs for MMP3 Gene

(17) SIMAP similar genes for MMP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MMP3: view

Variants for MMP3 Gene

Sequence variations from dbSNP and Humsavar for MMP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs679620 - 102,842,889(-) ACCTC(A/G)AAAAA reference, missense
rs476762 -- 102,839,976(+) CCAGA(A/T)CTAAA intron-variant
rs522616 -- 102,844,317(-) TTTCA(A/G)TTCTA upstream-variant-2KB
rs591058 -- 102,840,607(+) GAAAT(C/T)GAGAA intron-variant
rs655403 -- 102,837,776(+) TGGCC(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP3 Gene

Variant ID Type Subtype PubMed ID
nsv898335 CNV Loss 21882294
esv2663139 CNV Deletion 23128226
nsv898336 CNV Loss 21882294

Variation tolerance for MMP3 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP3 Gene

HapMap Linkage Disequilibrium report
MMP3
Human Gene Mutation Database (HGMD)
MMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP3 Gene

Disorders for MMP3 Gene

MalaCards: The human disease database

(46) MalaCards diseases for MMP3 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coronary heart disease 6
  • coronary heart disease, susceptibility to, 6
arthritis
  • inflammatory disorder of joint
synovitis
rheumatoid lung disease
  • rheumatoid lung
superior limbic keratoconjunctivitis
  • slk
- elite association - COSMIC cancer census association via MalaCards
Search MMP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP3_HUMAN
  • Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:12477941, ECO:0000269 PubMed:8662692}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.

Relevant External Links for MMP3

Genetic Association Database (GAD)
MMP3
Human Genome Epidemiology (HuGE) Navigator
MMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP3
genes like me logo Genes that share disorders with MMP3: view

No data available for Genatlas for MMP3 Gene

Publications for MMP3 Gene

  1. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. (PMID: 12477941) Yamada Y. … Yokota M. (N. Engl. J. Med. 2002) 3 4 48 67
  2. Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration. (PMID: 20009418) Yuan H.Y. … Xia Z.L. (J Occup Health 2010) 3 23
  3. Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth. (PMID: 19778329) Drozdzik A. … Drozdzik M. (J. Periodont. Res. 2010) 3 23
  4. Histological analysis of synovium by treatment of etanercept for rheumatoid arthritis. (PMID: 20374310) Suzuki Y. … Kanbe K. (Int J Rheum Dis 2009) 3 23
  5. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PMID: 19479237) Song X.Y. … Chan J.C. (Diabetologia 2009) 3 23

Products for MMP3 Gene

  • Addgene plasmids for MMP3

Sources for MMP3 Gene

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