Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MMP3 Gene

Aliases for MMP3 Gene

  • Matrix Metallopeptidase 3 2 3 5
  • Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase) 2 3
  • EC 3.4.24.17 4 58
  • Transin-1 3 4
  • STMY1 3 4
  • MMP-3 3 4
  • SL-1 3 4
  • Matrix Metalloproteinase-3 4
  • Proteoglycanase 3
  • Stromelysin 1 2
  • Stromelysin-1 3
  • EC 3.4.24 58
  • CHDS6 3
  • STR1 3
  • STMY 3

External Ids for MMP3 Gene

Previous HGNC Symbols for MMP3 Gene

  • STMY1
  • STMY

Previous GeneCards Identifiers for MMP3 Gene

  • GC11M104900
  • GC11M104063
  • GC11M102695
  • GC11M102199
  • GC11M102200
  • GC11M102211
  • GC11M102706
  • GC11M098634

Summaries for MMP3 Gene

Entrez Gene Summary for MMP3 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP3 Gene

MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include Coronary Heart Disease 6 and Arthritis. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.

UniProtKB/Swiss-Prot for MMP3 Gene

  • Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Tocris Summary for MMP3 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP3 Gene

Additional gene information for MMP3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP3 Gene

Genomics for MMP3 Gene

Regulatory Elements for MMP3 Gene

Enhancers for MMP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H102759 1.4 FANTOM5 Ensembl ENCODE 9.8 +81.8 81811 4 HDAC1 NFIB PLRG1 RFX5 ZNF366 ZNF350 RCOR1 FOS ATF7 CEBPB DYNC2H1 C11orf70 MMP1 MMP8 MMP3 MMP27 MMP7 BIRC2 LOC100421658 ENSG00000225678
GH11H102727 1.1 FANTOM5 Ensembl ENCODE 9.9 +115.7 115677 1 JUND JUN FOS MMP27 MMP10 MMP1 MMP3 RNU7-159P BIRC2 TMEM123 BIRC3 MMP8 WTAPP1
GH11H103035 1 Ensembl ENCODE 9.4 -192.3 -192338 1 CTCF ETV1 JUN MAX CEBPG RAD21 FOSL1 ZNF316 SMC3 ZNF143 RNU7-159P MMP3 RPL21P96 ENSG00000276521
GH11H102919 0.9 Ensembl ENCODE 10.4 -76.6 -76555 0 PKNOX1 ZNF687 TRIM22 BMI1 ELF1 DPF2 IKZF1 TARDBP NBN MLLT1 MMP13 MMP3 RNU7-159P
GH11H102729 0.8 Ensembl ENCODE 9.9 +113.5 113466 1 NONO JUN ZNF18 EGR2 MMP27 BIRC2 MMP10 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP3 Gene

Chromosome:
11
Start:
102,835,797 bp from pter
End:
102,843,803 bp from pter
Size:
8,007 bases
Orientation:
Minus strand

Genomic View for MMP3 Gene

Genes around MMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP3 Gene

Proteins for MMP3 Gene

  • Protein details for MMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08254-MMP3_HUMAN
    Recommended name:
    Stromelysin-1
    Protein Accession:
    P08254
    Secondary Accessions:
    • B2R8B8
    • Q3B7S0
    • Q6GRF8

    Protein attributes for MMP3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP3 Gene

neXtProt entry for MMP3 Gene

Selected DME Specific Peptides for MMP3 Gene

P08254:
  • HSLGLFH
  • VLAHAYAPGPG
  • PRCGVPD
  • DKYWRFDE
  • YRIVNYT
  • LFLVAAHE
  • FWRKSLR
  • IAEDFPG
  • IHTLGFP
  • GEADIMI
  • GTNLFLVA
  • GIQSLYG
  • QDDINGIQ

Post-translational modifications for MMP3 Gene

  • Glycosylation at posLast=120120
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Abcam assays for MMP3

Domains & Families for MMP3 Gene

Gene Families for MMP3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08254

UniProtKB/Swiss-Prot:

MMP3_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP3: view

Function for MMP3 Gene

Molecular function for MMP3 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing bone,interacting with ZBP89,playing a role in tumor metastasis
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage where P1, P2 and P3 are hydrophobic residues.
UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP3 Gene

Phenotypes From GWAS Catalog for MMP3 Gene

Gene Ontology (GO) - Molecular Function for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 15863497
GO:0004222 metalloendopeptidase activity IEA,TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 9573338
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MMP3: view
genes like me logo Genes that share phenotypes with MMP3: view

Animal Models for MMP3 Gene

MGI Knock Outs for MMP3:

Animal Model Products

CRISPR Products

miRNA for MMP3 Gene

miRTarBase miRNAs that target MMP3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP3
  • Applied Biological Materials Clones for MMP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP3 Gene

Localization for MMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space TAS 3360803
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP3: view

Pathways & Interactions for MMP3 Gene

genes like me logo Genes that share pathways with MMP3: view

SIGNOR curated interactions for MMP3 Gene

Activates:

Gene Ontology (GO) - Biological Process for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 12867428
GO:0010727 negative regulation of hydrogen peroxide metabolic process IDA 20969476
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process TAS,IEA --
GO:0032461 positive regulation of protein oligomerization IDA 19022250
genes like me logo Genes that share ontologies with MMP3: view

Drugs & Compounds for MMP3 Gene

(107) Drugs for MMP3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor, Target, antagonist MMPs inhibitor,board spectrum 4
Pravastatin Approved Pharma Competitive, Inhibitor 153
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 528
Chlorthalidone Approved Pharma 65
Lisinopril Approved, Investigational Pharma ACE inhibitor 119

(49) Additional Compounds for MMP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP3 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9

(8) ApexBio Compounds for MMP3 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor 130370-60-4
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent 10592-13-9
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
PD 166793 MMP inhibitor 199850-67-4
PTIQ 1032822-42-6
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
UK 356618 MMP-3 inhibitor,potent and selective 230961-08-7
UK 370106 MMP-3/MMP-12 Inhiibitor,highly selective 230961-21-4
genes like me logo Genes that share compounds with MMP3: view

Drug Products

Transcripts for MMP3 Gene

mRNA/cDNA for MMP3 Gene

Unigene Clusters for MMP3 Gene

Matrix metallopeptidase 3 (stromelysin 1, progelatinase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP3
  • Applied Biological Materials Clones for MMP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MMP3 Gene

No ASD Table

Relevant External Links for MMP3 Gene

GeneLoc Exon Structure for
MMP3
ECgene alternative splicing isoforms for
MMP3

Expression for MMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP3 Gene

This gene is overexpressed in Minor Salivary Gland (x29.0), Adipose - Subcutaneous (x6.7), and Nerve - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for MMP3 Gene

This gene is overexpressed in Synovial fluid (55.5) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MMP3 Gene:

MMP3

SOURCE GeneReport for Unigene cluster for MMP3 Gene:

Hs.375129

Evidence on tissue expression from TISSUES for MMP3 Gene

  • Lung(4.4)
  • Blood(2.7)
  • Skin(2.5)
  • Intestine(2.3)
  • Bone(2.2)
  • Heart(2.2)
  • Muscle(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with MMP3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP3 Gene

Orthologs for MMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP3 33 34
  • 98.67 (n)
dog
(Canis familiaris)
Mammalia MMP3 33 34
  • 84.56 (n)
cow
(Bos Taurus)
Mammalia MMP3 33 34
  • 84 (n)
mouse
(Mus musculus)
Mammalia Mmp3 33 16 34
  • 81.9 (n)
rat
(Rattus norvegicus)
Mammalia Mmp3 33
  • 81.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC428086 33
  • 62.37 (n)
-- 34
  • 53 (a)
ManyToMany
MMP10 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489571 33
  • 59.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 35
  • 44 (a)
Species where no ortholog for MMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP3 Gene

ENSEMBL:
Gene Tree for MMP3 (if available)
TreeFam:
Gene Tree for MMP3 (if available)

Paralogs for MMP3 Gene

(17) SIMAP similar genes for MMP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MMP3 Gene

genes like me logo Genes that share paralogs with MMP3: view

Variants for MMP3 Gene

Sequence variations from dbSNP and Humsavar for MMP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000987215 -- 102,841,438(+) TTGTA(C/T)GTCCT intron-variant
rs1001019605 -- 102,841,066(+) TCATC(A/G)TGAAG intron-variant
rs1001827942 -- 102,836,325(+) GAAAG(C/T)GTTTA intron-variant
rs1002989563 -- 102,844,211(+) AGGGT(C/G)TGTGA upstream-variant-2KB
rs1003020071 -- 102,843,890(+) ACTAG(A/G/T)CAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP3 Gene

Variant ID Type Subtype PubMed ID
esv2663139 CNV deletion 23128226
esv3627536 CNV loss 21293372

Variation tolerance for MMP3 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP3 Gene

Human Gene Mutation Database (HGMD)
MMP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP3 Gene

Disorders for MMP3 Gene

MalaCards: The human disease database

(58) MalaCards diseases for MMP3 Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coronary heart disease 6
  • chds6
arthritis
  • inflammatory disorder of joint
conjunctivochalasis
synovitis
lymph node disease
  • disorder of lymph node
- elite association - COSMIC cancer census association via MalaCards
Search MMP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP3_HUMAN
  • Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:12477941, ECO:0000269 PubMed:8662692}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.

Relevant External Links for MMP3

Genetic Association Database (GAD)
MMP3
Human Genome Epidemiology (HuGE) Navigator
MMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP3
genes like me logo Genes that share disorders with MMP3: view

No data available for Genatlas for MMP3 Gene

Publications for MMP3 Gene

  1. Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth. (PMID: 19778329) Drozdzik A … Drozdzik M (Journal of periodontal research 2010) 3 22 45 60
  2. Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration. (PMID: 20009418) Yuan HY … Xia ZL (Journal of occupational health 2010) 3 22 45 60
  3. Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. (PMID: 18674955) Vairaktaris E … Patsouris E (Oral oncology 2009) 3 22 45 60
  4. Haplotype analysis of the stromelysin-1 (MMP3) and gelatinase B (MMP9) genes in relation to coronary heart disease. (PMID: 19438845) Wu N … Yang Y (Annals of human genetics 2009) 3 22 45 60
  5. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PMID: 19479237) Song XY … Chan JC (Diabetologia 2009) 3 22 45 60

Products for MMP3 Gene

  • Addgene plasmids for MMP3

Sources for MMP3 Gene

Content
Loading form....