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MMP28 Gene

protein-coding   GIFtS: 58
GCID: GC17M034092

Matrix Metallopeptidase 28

(Previous name: matrix metalloproteinase 28)
  See MMP28-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 281 2     MM282
Matrix Metalloproteinase 281 2     Matrix Metalloproteinase-282
MMP-282 3     Putative MMP28 Gene Product2
MMP252 3     EC 3.4.24.-3
EPILYSIN2     Epilysin3

External Ids:    HGNC: 143661   Entrez Gene: 791482   Ensembl: ENSG000001292707   OMIM: 6084175   UniProtKB: Q9H2393   

Export aliases for MMP28 gene to outside databases

Previous GC identifers: GC17M033862 GC17M036128 GC17M034238 GC17M031116 GC17M030278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP28 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for
both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and
disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its
expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants
encoding different isoforms have been described. (provided by RefSeq, Mar 2010)

GeneCards Summary for MMP28 Gene:
MMP28 (matrix metallopeptidase 28) is a protein-coding gene. Diseases associated with MMP28 include encephalomyelitis, and asthma. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding.

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
Function: Can degrade casein. Could play a role in tissues homeostasis and repair

summary for MMP28 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP28 gene promoter:
         c-Fos   Egr-3   AP-1   Pax-5   HOXA3   AP-4   C/EBPalpha   CHOP-10   JunD   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP28 promoter sequence
   Search Chromatin IP Primers for MMP28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

MMP28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP28 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034092:  view genomic region     (about GC identifiers)

Start:
34,083,268 bp from pter      End:
34,122,711 bp from pter
Size:
39,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239 (See protein sequence)
Recommended Name: Matrix metalloproteinase-28 precursor  
Size: 520 amino acids; 58939 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Secondary accessions: Q96F04 Q96TE2
Alternative splicing: 2 isoforms:  Q9H239-1   Q9H239-2   

Explore the universe of human proteins at neXtProt for MMP28: NX_Q9H239

Explore proteomics data for MMP28 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn164, Asn355
  • Modification sites at PhosphoSitePlus

  • See MMP28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027449.1  NP_077278.1  

    ENSEMBL proteins: 
     ENSP00000466671   ENSP00000464731   ENSP00000468709   ENSP00000467034   ENSP00000468249  
     ENSP00000466155   ENSP00000468241   ENSP00000250144  

    MMP28 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP28

     
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    antibodies-online proteins for MMP28 (3 products) 

     
    antibodies-online peptides for MMP28

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    antibodies-online antibodies for MMP28 (51 products) 

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    antibodies-online kits for MMP28 (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP28
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 9):
     IPR028735 MMP28
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat

    Graphical View of Domain Structure for InterPro Entry Q9H239

    ProtoNet protein and cluster: Q9H239

    1 Blocks protein domain: IPB002477 Putative peptidoglycan binding domain 1

    UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP28_HUMAN, Q9H239
    Function: Can degrade casein. Could play a role in tissues homeostasis and repair

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity TAS11121398
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MMP28           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MMP28:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp28):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with MMP28           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmp28tm1Mani for MMP28

       genOway: Develop your customized and physiologically relevant rodent model for MMP28

    miRNA
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    miRTarBase miRNAs that target MMP28:
    hsa-mir-181c-3p (MIRT038668), hsa-mir-16-5p (MIRT051134)

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    3 qRT-PCR Assays for microRNAs that regulate MMP28:
    hsa-miR-1226 hsa-miR-431 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP28 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP28

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP28_HUMAN, Q9H239: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS11121398

    Find genes that share ontologies with MMP28           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP28 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP28
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP28
        Matrix Metalloproteinases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP28
    Interactions:

        Search GeneGlobe Interaction Network for MMP28

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MMP28 (Q9H2393 ENSP000002501444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926243I2D: score=1 
    RAD54BQ9Y6203I2D: score=1 
    TNFSF11ENSP000002398494STRING: ENSP00000239849
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with MMP28           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP28 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP28    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP28    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP28 gene (3 alternative transcripts): 
    NM_001032278.1  NM_024302.3  NM_032950.2  

    Unigene Cluster for MMP28:

    Matrix metallopeptidase 28
    Hs.380710  [show with all ESTs]
    Unigene Representative Sequence: AF330002
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587687 ENST00000587639 ENST00000589103 ENST00000589061 ENST00000590643
    ENST00000587923 ENST00000593125 ENST00000250144(uc002hjw.1 uc002hjy.1 uc002hjz.1 uc002hka.3)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MMP28:
    hsa-miR-1226 hsa-miR-431 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP28 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF219624.1 AF315683.1 AF330002.1 AY358987.1 BC011774.2 

    6 DOTS entries:

    DT.75101553  DT.40190771  DT.92416694  DT.70103597  DT.97813586  DT.97805580 

    Selected AceView cDNA sequences (see all 70):

    BM701844 BM727133 CA432754 NM_032950 BQ016272 CR590246 AA813101 BI223860 
    AA583884 BC002631 BC011774 BM702847 BQ030109 BG722422 BQ574894 BF437291 
    BM560236 BX360789 AF219624 BX360790 AK122604 BF437401 NM_024302 BI914743 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MMP28    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                                            -                                                         
    SP2:                                            -                       -           -                     
    SP3:                                            -                                   -                     
    SP4:                                            -     -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MMP28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGGGATG
    MMP28 Expression
    About this image


    MMP28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
    MMP28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380710

    UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
    Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and
    skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes.
    Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin

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    QuantiFast Probe-based Assays in human, mouse, rat MMP28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP28 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp281 , 5 matrix metallopeptidase 28 (epilysin)1, 5 84.05(n)1
    85.29(a)1
      11 (50.39 cM)5
    1184531  NM_080453.21  NP_536701.11 
     834407685 
    chicken
    (Gallus gallus)
    Aves MMP281 matrix metallopeptidase 28 65.89(n)
    61.91(a)
      417523  XM_415771.4  XP_415771.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685062 hypothetical protein MGC68506 76.93(n)    BC061659.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000056701 matrix metalloproteinase-28-like 59.53(n)
    55.03(a)
      100005670  XM_001337545.4  XP_001337581.3 


    ENSEMBL Gene Tree for MMP28 (if available)
    TreeFam Gene Tree for MMP28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP28 gene
    1 SIMAP similar gene for MMP28 using alignment to 6 protein entries:     MMP28_HUMAN (see all proteins):
    MMP26

    Find genes that share paralogs with MMP28           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP28 (see all 619)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1176515611,2
    C,Funtested134155770(+) CCATCG/AGGCCT 2 /P syn12Minor allele frequency- A:0.05EA EU 343
    rs614957851,2
    C--34109823(+) TTTTT-/TAATTT 1 -- int10--------
    rs1122448101,2
    C,F--34109973(+) CTACAG/AGCACC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1857498971,2
    --34154583(+) GAGCTG/TGTTCC 1 -- ds50010--------
    rs757004331,2
    F--34154638(+) TGGGAA/GTGCCT 1 -- ds50010--------
    rs1432671801,2
    C--34154775(+) ACCTCA/TCCCTG 1 -- ds50010--------
    rs795440641,2
    C,F--34154810(+) TGGAGC/ATGCAA 1 -- ds50011Minor allele frequency- A:0.07NA 120
    rs1466647591,2
    C--34154869(+) CTCTG-/CACACAC 1 -- ds50010--------
    rs10564161,2
    C,F,H--34155114(-) CCTCAG/AAGGCC 1 -- ut31 ese38Minor allele frequency- A:0.02MN NS EA NA 876
    rs1483252361,2
    --34155129(+) AGACGA/CCTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP28 (34083268 - 34122711 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP28: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP28
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608417    OMIM disorders: --

    2 diseases for MMP28:    
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    encephalomyelitis    asthma


    Find genes that share disorders with MMP28           About GenesLikeMe

    3 Novoseek inferred disease relationships for MMP28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 22.3 3 11255011 (1), 12164918 (1), 16730219 (1)
    tumors 5.38 3 11255011 (1), 15185874 (1), 16730219 (1)
    cancer 0 1 12164918 (1)

    Human Genome Epidemiology (HuGE) Navigator: MMP28 (1 document)

    Export disorders for MMP28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP28 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with MMP28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PubMed id 11121398)1, 2, 3, 9 Lohi J.... Parks W.C. (J. Biol. Chem. 2001)
    2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PubMed id 11255011)1, 2, 3, 9 Marchenko G.N. and Strongin A.Y. (Gene 2001)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs. (PubMed id 20003223)1, 9 Gruber H.E....Hanley E.N. (amp 2009)
    5. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PubMed id 19379669)1, 9 Heiskanen T.J....Keski-Oja J. (Matrix Biol. 2009)
    6. Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. (PubMed id 15953044)1, 9 RenA^ F....Cannas M. (Wound Repair Regen 2005)
    7. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. (PubMed id 12164918)1, 9 Saarialho-Kere U....Lohi J. (J. Invest. Dermatol. 2002)
    8. Expression and function of matrix metalloproteinase (MMP)-28. (PubMed id 19375502)1, 9 Rodgers U.R....Clark I.M. (Matrix Biol. 2009)
    9. MMP-28 as a regulator of myelination. (PubMed id 18778487)1, 9 Werner S.R....Smith R.C. (BMC Neurosci 2008)
    10. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PubMed id 20144149)1, 9 Swingler T.E....Clark I.M. (Biochem. J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79148 HGNC: 14366 AceView: MMP28 Ensembl:ENSG00000129270 euGenes: HUgn79148
    ECgene: MMP28 H-InvDB: MMP28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP28 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP28 gene:
    Search GeneIP for patents involving MMP28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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