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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP28 Gene

protein-coding   GIFtS: 55
GCID: GC17M034092

Matrix Metallopeptidase 28

(Previous name: matrix metalloproteinase 28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 281 2     MM282
Matrix Metalloproteinase 281 2     Matrix Metalloproteinase-282
MMP-282 3     EC 3.4.24.-3
MMP252 3     Epilysin3
EPILYSIN2     

External Ids:    HGNC: 143661   Entrez Gene: 791482   Ensembl: ENSG000001292707   OMIM: 6084175   UniProtKB: Q9H2393   

Export aliases for MMP28 gene to outside databases

Previous GC identifers: GC17M033862 GC17M036128 GC17M034238 GC17M031116 GC17M030278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP28 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for
both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and
disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its
expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants
encoding different isoforms have been described. (provided by RefSeq, Mar 2010)

GeneCards Summary for MMP28 Gene: 
MMP28 (matrix metallopeptidase 28) is a protein-coding gene. Diseases associated with MMP28 include hypertrophic scars, and encephalomyelitis, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and GnRH Signaling. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding.

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
Function: Can degrade casein. Could play a role in tissues homeostasis and repair

summary for MMP28 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP28 gene promoter:
         c-Fos   Egr-3   AP-1   Pax-5   HOXA3   AP-4   C/EBPalpha   CHOP-10   JunD   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP28 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

MMP28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP28 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M034092:  view genomic region     (about GC identifiers)

Start:
34,083,268 bp from pter      End:
34,122,711 bp from pter
Size:
39,444 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239 (See protein sequence)
Recommended Name: Matrix metalloproteinase-28 precursor  
Size: 520 amino acids; 58939 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q96F04 Q96TE2
Alternative splicing: 2 isoforms:  Q9H239-1   Q9H239-2   

Explore the universe of human proteins at neXtProt for MMP28: NX_Q9H239

Explore proteomics data for MMP28 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • View neXtProt modification sites for NX_Q9H239

  • MMP28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MMP28 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001027449.1  NP_077278.1  

    ENSEMBL proteins: 
     ENSP00000466671   ENSP00000464731   ENSP00000468709   ENSP00000467034   ENSP00000468249  
     ENSP00000466155   ENSP00000468241   ENSP00000250144  

    Human Recombinant Protein Products for MMP28: 
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    Novus Biologicals MMP28 Protein
    Novus Biologicals MMP28 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP28 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS11121398

    MMP28 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MMP28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP28 
    Cell-surface protein and extracellular matrix metalloproteinases

    5/8 InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat
     IPR006026 Peptidase_Metallo

    Graphical View of Domain Structure for InterPro Entry Q9H239

    ProtoNet protein and cluster: Q9H239

    1 Blocks protein domain: IPB002477 Putative peptidoglycan binding domain 1

    UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP28_HUMAN, Q9H239
    Function: Can degrade casein. Could play a role in tissues homeostasis and repair

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity TAS11121398
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MMP28:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp28):
     cellular  immune system 

    MMP28 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp28tm1Mani for MMP28

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MMP28 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MMP28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP28 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP28 

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    hsa-miR-1226 hsa-miR-431 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP28 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MMP28 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MMP28 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP28
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP28
        Matrix Metalloproteinases


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMP28

    2 Interacting proteins for MMP28 (Q9H2393) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926243I2D: score=1 
    RAD54BQ9Y6203I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--

    MMP28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for MMP28:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP28 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP28    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP28    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    Search CenterWatch for drugs/clinical trials and news about MMP28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MMP28 gene (3 alternative transcripts): 
    NM_001032278.1  NM_024302.3  NM_032950.2  

    Unigene Cluster for MMP28:

    Matrix metallopeptidase 28
    Hs.380710  [show with all ESTs]
    Unigene Representative Sequence: AF330002
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587687 ENST00000587639 ENST00000589103 ENST00000589061 ENST00000590643
    ENST00000587923 ENST00000593125 ENST00000250144(uc002hjw.1 uc002hjy.1 uc002hjz.1 uc002hka.3)

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    hsa-miR-1226 hsa-miR-431 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP28 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP28
    Sirion Biotech Customized lentivirus for stable overexpression of MMP28 
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    Additional mRNA sequence: 

    AF219624.1 AF315683.1 AF330002.1 AY358987.1 BC011774.2 

    6 DOTS entries:

    DT.75101553  DT.40190771  DT.92416694  DT.70103597  DT.97813586  DT.97805580 

    24/70 AceView cDNA sequences (see all 70):

    BQ016272 NM_032950 AA583884 BC011774 CA432754 BM727133 BM701844 AA813101 
    BC002631 BI223860 CR590246 AI962342 BM702847 BQ029740 AW207107 BX360790 
    AF219624 BM544516 BF437291 BI914743 BM560236 AI608686 AF330002 AK122604 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MMP28    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                                            -                                                         
    SP2:                                            -                       -           -                     
    SP3:                                            -                                   -                     
    SP4:                                            -     -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MMP28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP28 expression in normal human tissues (normalized intensities)      MMP28 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGGGATG
    MMP28 Expression
    About this image


    MMP28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor RP1-MV2-8
     
     Esophagus
             Human Esophageal Epithelial Cells (HEEpiC)   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells

    See MMP28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP28

    SOURCE GeneReport for Unigene cluster: Hs.380710

    UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239
    Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and
    skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes.
    Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin

        SABiosciences Custom PCR Arrays for MMP28
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MMP28 gene from 5/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp281 , 5 matrix metallopeptidase 28 (epilysin)1, 5 84.05(n)1
    85.29(a)1
      11 (50.39 cM)5
    1184531  NM_080453.21  NP_536701.11 
     834407685 
    chicken
    (Gallus gallus)
    Aves MMP281 matrix metallopeptidase 28 66.02(n)
    62.07(a)
      417523  XM_415771.3  XP_415771.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685062 hypothetical protein MGC68506 76.93(n)    BC061659.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000056701 matrix metalloproteinase-28-like 59.6(n)
    55.03(a)
      100005670  XM_001337545.3  XP_001337581.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C31B8.81 Protein C31B8.8 42.76(n)
    34.02(a)
      178748  NM_071389.3  NP_503790.1 


    ENSEMBL Gene Tree for MMP28 (if available)
    TreeFam Gene Tree for MMP28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP28 gene
    1 SIMAP similar gene for MMP28 using alignment to 6 protein entries:     MMP28_HUMAN (see all proteins):
    MMP26

    MMP28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 SNPs in MMP28 are shown (see all 619)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1176515611,2
    C,Funtested134155770(+) CCATCG/AGGCCT 2 /P syn12Minor allele frequency- A:0.05EA EU 343
    rs614957851,2
    C--34109823(+) TTTTT-/TAATTT 1 -- int10--------
    rs1122448101,2
    C,F--34109973(+) CTACAG/AGCACC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1857498971,2
    --34154583(+) GAGCTG/TGTTCC 1 -- ds50010--------
    rs757004331,2
    F--34154638(+) TGGGAA/GTGCCT 1 -- ds50010--------
    rs1432671801,2
    C--34154775(+) ACCTCA/TCCCTG 1 -- ds50010--------
    rs795440641,2
    C,F--34154810(+) TGGAGC/ATGCAA 1 -- ds50011Minor allele frequency- A:0.07NA 120
    rs1466647591,2
    C--34154869(+) CTCTG-/CACACAC 1 -- ds50010--------
    rs10564161,2
    C,F,H--34155114(-) CCTCAG/AAGGCC 1 -- ut31 ese38Minor allele frequency- A:0.02MN NS EA NA 876
    rs1483252361,2
    --34155129(+) AGACGA/CCTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP28 (34083268 - 34122711 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP28: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP28
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608417    OMIM disorders: --

    13 diseases for MMP28:    About MalaCards
    hypertrophic scars    encephalomyelitis    oral squamous cell carcinoma    asthma
    arthritis    osteoarthritis    multiple sclerosis    squamous cell carcinoma
    colon cancer    gastric cancer    rheumatoid arthritis    adenocarcinoma
    pancreatitis


    MMP28 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MMP28 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 22.3 3 11255011 (1), 12164918 (1), 16730219 (1)
    tumors 5.38 3 11255011 (1), 15185874 (1), 16730219 (1)
    cancer 0 1 12164918 (1)

    Human Genome Epidemiology (HuGE) Navigator: MMP28 (1 document)

    Export disorders for MMP28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP28 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with MMP28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PubMed id 11121398)1, 2, 3, 9 Lohi J.... Parks W.C. (2001)
    2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PubMed id 11255011)1, 2, 3, 9 Marchenko G.N. and Strongin A.Y. (2001)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Matrix metalloproteinase 28, a novel matrix metallopr oteinase, is constitutively expressed in human intervertebral disc tissue and i s present in matrix of more degenerated discs. (PubMed id 20003223)1, 9 Gruber H.E....Hanley E.N. (2009)
    5. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PubMed id 19379669)1, 9 Heiskanen T.J....Keski-Oja J. (2009)
    6. Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. (PubMed id 15953044)1, 9 Reno F....Cannas M. (2005)
    7. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. (PubMed id 12164918)1, 9 Saarialho-Kere U....Lohi J. (2002)
    8. Expression and function of matrix metalloproteinase ( MMP)-28. (PubMed id 19375502)1, 9 Rodgers U.R....Clark I.M. (2009)
    9. MMP-28 as a regulator of myelination. (PubMed id 18778487)1, 9 Werner S.R....Smith R.C. (2008)
    10. MMP28 gene expression is regulated by Sp1 transcripti on factor acetylation. (PubMed id 20144149)1, 9 Swingler T.E....Clark I.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79148 HGNC: 14366 AceView: MMP28 Ensembl:ENSG00000129270 euGenes: HUgn79148
    ECgene: MMP28 H-InvDB: MMP28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP28 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MMP28 gene:
    Search GeneIP for patents involving MMP28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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