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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP28 Gene

protein-coding GIFtS: 55
GCID: GC17M034092

matrix metallopeptidase 28

(Previous name: matrix metalloproteinase 28 )

Explore 14 diseases affiliated with
MMP28 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 28¹ ²		MMP25² ³
MMP-28¹ ² ³		MMP-25¹
EPILYSIN¹ ²		Matrix Metalloproteinase-28²
MM28¹ ²		EC 3.4.24.-³
Matrix Metalloproteinase 28¹ ²		Epilysin³

External Ids:	HGNC: 14366¹	Entrez Gene: 79148²	Ensembl: ENSG00000129270⁷	OMIM: 608417⁵	UniProtKB: Q9H239³

Export aliases for MMP28 gene to outside databases

Previous GC identifers: GC17M033862 GC17M036128 GC17M034238 GC17M031116 GC17M030278

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP28:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both

normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease

processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression

pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding

different isoforms have been described. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239

Function: Can degrade casein. Could play a role in tissues homeostasis and repair

summary for MMP28:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP28

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP28 gene promoter:
c-Fos Egr-3 AP-1 Pax-5 HOXA3 AP-4 C/EBPalpha CHOP-10 JunD Chx10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP28 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP28

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP28

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1

MMP28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP28 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M034092: view genomic region (about GC identifiers)

Start:	34,083,268 bp from pter	End:	34,122,711 bp from pter
Size:	39,444 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239 (See protein sequence)

Recommended Name: Matrix metalloproteinase-28 precursor

Size: 520 amino acids; 58939 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Cofactor: Calcium (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q96F04 Q96TE2

Alternative splicing: 2 isoforms: Q9H239-1 Q9H239-2

Explore the universe of human proteins at neXtProt for MMP28: NX_Q9H239

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View neXtProt modification sites for NX_Q9H239

MMP28 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001027449.1 NP_077278.1

ENSEMBL proteins:

ENSP00000466671 ENSP00000464731 ENSP00000468709 ENSP00000467034 ENSP00000468249

ENSP00000466155 ENSP00000468241 ENSP00000250144

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	Uscn Proteins for MMP28

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	NAS	11121398

MMP28 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MMP28

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP28 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR024079 MetalloPept_cat_dom

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018487 Hemopexin/matrixin_repeat

IPR006026 Peptidase_Metallo

Graphical View of Domain Structure for InterPro Entry Q9H239

ProtoNet protein and cluster: Q9H239

1 Blocks protein family: IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239

Function: Can degrade casein. Could play a role in tissues homeostasis and repair

Enzyme Number (IUBMB): EC 3.4.24.-¹

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP28
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		hsa-miR-1226 hsa-miR-431 hsa-miR-3647-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	11121398
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP28 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MMP28:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Mmp28^tm1Mani for MMP28
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp28):

cellular

immune system

MMP28 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

Integrin Pathway

UPA-UPAR Pathway

0.51

Transendothelial Migration of Leukocytes

0.38

GPCR Pathway

Pancreatic Adenocarcinoma

0.55

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP28

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 BioSystems Pathway for MMP28

Matrix Metalloproteinases

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MMP28

2 Interacting proteins for MMP28 (Q9H239³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APPBP2	Q92624³	I2D: score=1
RAD54B	Q9Y620³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	--

MMP28 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for MMP28:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for MMP28 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP28 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MMP28 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951

Search CenterWatch for drugs/clinical trials and news about MMP28

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP28 gene (3 alternative transcripts):

NM_001032278.1 NM_024302.3 NM_032950.2

Unigene Cluster for MMP28:

Matrix metallopeptidase 28

Hs.380710 [show with all ESTs]

Unigene Representative Sequence: AF330002

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000587687 ENST00000587639 ENST00000589103 ENST00000589061 ENST00000590643

ENST00000587923 ENST00000593125 ENST00000250144(uc002hjw.1 uc002hjy.1 uc002hjz.1 uc002hka.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP28
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP28:
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Additional cDNA sequence:

AF219624.1 AF315683.1 AF330002.1 AY358987.1 BC011774.2

6 DOTS entries:

DT.75101553 DT.40190771 DT.92416694 DT.70103597 DT.97805580 DT.97813586

24/70 AceView cDNA sequences (see all 70):

BQ016272 NM_032950 AA583884 CA432754 BM727133 AA813101 CR590246 BM701844

BI223860 BC002631 BC011774 BM702847 AI608686 BM544516 BM009001 AW207107

BQ030109 BM560236 AI962342 AW182674 AF330002 AW206067 BG722422 BU729044

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MMP28 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:															-
SP2:															-								-				-
SP3:															-												-
SP4:															-		-
SP5:

ECgene alternative splicing isoforms for MMP28

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGGGGATG

About this image

MMP28 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MMP28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP28

SOURCE GeneReport for Unigene cluster: Hs.380710

UniProtKB/Swiss-Prot: MMP28_HUMAN, Q9H239

Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin.

Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely

expressed in several carcinomas as well. Is up-regulated in response to injury in the skin

SABiosciences Custom PCR Arrays for MMP28

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP28

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MMP28 gene from 5/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Mmp28^{1 , 5}	matrix metallopeptidase 28 (epilysin)^{1, 5}	84.05(n)¹ 85.29(a)¹	11 (50.39 cM)⁵ 118453¹ NM_080453.2¹ NP_536701.1¹ 83440768⁵
chicken (Gallus gallus)	Aves	MMP28¹	matrix metallopeptidase 28	66.02(n) 62.07(a)	417523 XM_415771.3 XP_415771.3
African clawed frog (Xenopus laevis)	Amphibia	MGC68506²	hypothetical protein MGC68506	76.93(n)	BC061659.1
zebrafish (Danio rerio)	Actinopterygii	LOC100005670¹	matrix metalloproteinase-28-like	59.6(n) 55.03(a)	100005670 XM_001337545.3 XP_001337581.3
worm (Caenorhabditis elegans)	Secernentea	CELE_C31B8.8¹	Protein C31B8.8	42.76(n) 34.02(a)	178748 NM_071389.3 NP_503790.1

ENSEMBL Gene Tree for MMP28 (if available)
TreeFam Gene Tree for MMP28 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75700433^1,2		--	30277690(+)	`TGGGAA/GTGCCT`	1	--	ds500¹		0	--	--	--	--
rs113987867^1,2		--	30291497(+)	`GCCTGT/CGGGAG`	1	--	int¹		1		CSA	1
rs35072058^1,2		--	30292347(+)	`AATTCC/TCCTGC`	1	--	int¹		0	--	--	--	--
rs12937439^1,2	C	--	30292663(+)	`CATTCC/GTTAAT`	1	--	int¹		0	--	--	--	--
rs112658687^1,2		--	30292771(+)	`AGGCCG/AAGGTG`	1	--	int¹		1		CSA	2
rs201162071^1,2	C	--	30293026(-)	`TATTTA/TCTTTT`	1	--	int¹		0	--	--	--	--
rs112757359^1,2		--	30293214(+)	`ACAGAG/CGAAAC`	1	--	int¹		1		CSA	2
rs113961817^1,2	C,	--	30293378(+)	`TTAGTC/ACTGCT`	1	--	int¹		1		NA	2
rs117177090^1,2	C,F,	--	30293532(+)	`TTCAAA/TGTGGC`	1	--	int¹		1		EA	120
rs72829950^1,2	C,	--	30294189(+)	`GCTGCA/TTGCCA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MMP28 (34083268 - 34122711 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP28: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP28

DNA2.0 Custom Variant and Variant Library Synthesis for MMP28

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP28 for disorders           About GeneDecksing

OMIM gene information: 608417    OMIM disorders: --

14 diseases for MMP28:    About MalaCards

encephalomyelitis arthritis oral squamous cell carcinoma squamous cell carcinoma

asthma rheumatoid arthritis multiple sclerosis colon cancer

osteoarthritis gastric cancer lung carcinoma carcinoma

adenocarcinoma pancreatitis

3 Novoseek disease relationships for MMP28 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma	22.3	3	11255011 (1), 12164918 (1), 16730219 (1)
tumors	5.38	3	11255011 (1), 15185874 (1), 16730219 (1)
cancer	0	1	12164918 (1)

Human Genome Epidemiology (HuGE) Navigator: MMP28 (1 document)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MMP28 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with MMP28)

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Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PubMed id 11121398)^{1, 2, 3, 9} Lohi J.... Parks W.C. (2001)
MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PubMed id 11255011)^{1, 2, 3, 9} Marchenko G.N. and Strongin A.Y. (2001)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Matrix metalloproteinase 28, a novel matrix metallopr oteinase, is constitutively expressed in human intervertebral disc tissue and i s present in matrix of more degenerated discs. (PubMed id 20003223)^{1, 9} Gruber H.E....Hanley E.N. (2009)
Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PubMed id 19379669)^{1, 9} Heiskanen T.J....Keski-Oja J. (2009)
Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. (PubMed id 15953044)^{1, 9} Reno F....Cannas M. (2005)
Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. (PubMed id 12164918)^{1, 9} Saarialho-Kere U....Lohi J. (2002)
Expression and function of matrix metalloproteinase ( MMP)-28. (PubMed id 19375502)^{1, 9} Rodgers U.R....Clark I.M. (2009)
MMP-28 as a regulator of myelination. (PubMed id 18778487)^{1, 9} Werner S.R....Smith R.C. (2008)
MMP28 gene expression is regulated by Sp1 transcripti on factor acetylation. (PubMed id 20144149)^{1, 9} Swingler T.E....Clark I.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79148	HGNC: 14366	AceView: MMP28	Ensembl:ENSG00000129270	euGenes: HUgn79148
ECgene: MMP28	H-InvDB: MMP28

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MMP28	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP28	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MMP28 gene
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Patent Information for MMP28 gene:
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matrix metallopeptidase 28

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matrix metallopeptidase 28

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