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Aliases for MMP28 Gene

Aliases for MMP28 Gene

  • Matrix Metallopeptidase 28 2 3 5
  • EPILYSIN 3 4
  • MMP-28 3 4
  • MMP25 3 4
  • Matrix Metalloprotease MMP25 3
  • Matrix Metalloproteinase 28 2
  • EC 3.4.24.- 4
  • MMP-25 3
  • MM28 3

External Ids for MMP28 Gene

Previous GeneCards Identifiers for MMP28 Gene

  • GC17M033862
  • GC17M036128
  • GC17M034238
  • GC17M031116
  • GC17M034092
  • GC17M030278

Summaries for MMP28 Gene

Entrez Gene Summary for MMP28 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for MMP28 Gene

MMP28 (Matrix Metallopeptidase 28) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP28 Gene

  • Can degrade casein. Could play a role in tissues homeostasis and repair.

Tocris Summary for MMP28 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP28 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP28 Gene

Genomics for MMP28 Gene

Regulatory Elements for MMP28 Gene

Promoters for MMP28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP28 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP28 Gene

Chromosome:
17
Start:
35,756,249 bp from pter
End:
35,795,707 bp from pter
Size:
39,459 bases
Orientation:
Minus strand

Genomic View for MMP28 Gene

Genes around MMP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP28 Gene

Proteins for MMP28 Gene

  • Protein details for MMP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H239-MMP28_HUMAN
    Recommended name:
    Matrix metalloproteinase-28
    Protein Accession:
    Q9H239
    Secondary Accessions:
    • Q96F04
    • Q96TE2

    Protein attributes for MMP28 Gene

    Size:
    520 amino acids
    Molecular mass:
    58939 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP28 Gene

Proteomics data for MMP28 Gene at MOPED

Post-translational modifications for MMP28 Gene

Other Protein References for MMP28 Gene

Antibody Products

No data available for DME Specific Peptides for MMP28 Gene

Domains & Families for MMP28 Gene

Gene Families for MMP28 Gene

Suggested Antigen Peptide Sequences for MMP28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H239

UniProtKB/Swiss-Prot:

MMP28_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP28: view

Function for MMP28 Gene

Molecular function for MMP28 Gene

UniProtKB/Swiss-Prot Function:
Can degrade casein. Could play a role in tissues homeostasis and repair.

Enzyme Numbers (IUBMB) for MMP28 Gene

Gene Ontology (GO) - Molecular Function for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS 11121398
genes like me logo Genes that share ontologies with MMP28: view
genes like me logo Genes that share phenotypes with MMP28: view

Animal Models for MMP28 Gene

MGI Knock Outs for MMP28:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP28

miRNA for MMP28 Gene

miRTarBase miRNAs that target MMP28

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP28 Gene

Localization for MMP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP28 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP28 Gene COMPARTMENTS Subcellular localization image for MMP28 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MMP28: view

Pathways & Interactions for MMP28 Gene

genes like me logo Genes that share pathways with MMP28: view

Interacting Proteins for MMP28 Gene

Selected Interacting proteins: Q9H239-MMP28_HUMAN for MMP28 Gene via I2D

Symbol External ID(s) Details
APPBP2
RAD54B

Gene Ontology (GO) - Biological Process for MMP28 Gene

None

No data available for SIGNOR curated interactions for MMP28 Gene

Drugs & Compounds for MMP28 Gene

(2) Drugs for MMP28 Gene - From: HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
calcium Nutra 0

(4) Additional Compounds for MMP28 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP28 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP28: view

Transcripts for MMP28 Gene

Unigene Clusters for MMP28 Gene

Matrix metallopeptidase 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP28 Gene

No ASD Table

Relevant External Links for MMP28 Gene

GeneLoc Exon Structure for
MMP28
ECgene alternative splicing isoforms for
MMP28

Expression for MMP28 Gene

mRNA expression in normal human tissues for MMP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP28 Gene

This gene is overexpressed in Testis (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP28 Gene



SOURCE GeneReport for Unigene cluster for MMP28 Gene Hs.380710

mRNA Expression by UniProt/SwissProt for MMP28 Gene

Q9H239-MMP28_HUMAN
Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.
genes like me logo Genes that share expression patterns with MMP28: view

Protein tissue co-expression partners for MMP28 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MMP28 Gene

Orthologs for MMP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP28 35
  • 78.61 (n)
  • 75.2 (a)
dog
(Canis familiaris)
Mammalia MMP28 35
  • 87.82 (n)
  • 88.27 (a)
mouse
(Mus musculus)
Mammalia Mmp28 35
  • 84.05 (n)
  • 85.29 (a)
Mmp28 16
rat
(Rattus norvegicus)
Mammalia Mmp28 35
  • 84 (n)
  • 84.86 (a)
chicken
(Gallus gallus)
Aves MMP28 35
  • 65.89 (n)
  • 61.91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp28 35
  • 58.53 (n)
  • 58.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68506 35
zebrafish
(Danio rerio)
Actinopterygii LOC100005670 35
  • 59.53 (n)
  • 55.03 (a)
Species with no ortholog for MMP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP28 Gene

ENSEMBL:
Gene Tree for MMP28 (if available)
TreeFam:
Gene Tree for MMP28 (if available)

Paralogs for MMP28 Gene

Paralogs for MMP28 Gene

(1) SIMAP similar genes for MMP28 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MMP28: view

Variants for MMP28 Gene

Sequence variations from dbSNP and Humsavar for MMP28 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs170501 -- 35,757,524(-) AGTTA(C/T)TAAGG intron-variant
rs226430 -- 35,787,244(-) GTTCT(G/T)GCTGT intron-variant
rs226431 -- 35,773,822(+) TGCAG(C/T)GTCAG intron-variant
rs2035476 -- 35,782,369(+) GTTAA(A/C/G/T)AAATA intron-variant
rs1056414 -- 35,766,038(-) GCCCC(A/C)CCCCC intron-variant, utr-variant-3-prime

Variation tolerance for MMP28 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP28 Gene

HapMap Linkage Disequilibrium report
MMP28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP28 Gene

Disorders for MMP28 Gene

Relevant External Links for MMP28

Human Genome Epidemiology (HuGE) Navigator
MMP28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP28

No disorders were found for MMP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP28 Gene

Publications for MMP28 Gene

  1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PMID: 11121398) Lohi J. … Parks W.C. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PMID: 11255011) Marchenko G.N. … Strongin A.Y. (Gene 2001) 2 3 23
  3. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PMID: 20144149) Swingler T.E. … Clark I.M. (Biochem. J. 2010) 3 23
  4. Expression and function of matrix metalloproteinase (MMP)-28. (PMID: 19375502) Rodgers U.R. … Clark I.M. (Matrix Biol. 2009) 3 23
  5. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PMID: 19379669) Heiskanen T.J. … Keski-Oja J. (Matrix Biol. 2009) 3 23

Products for MMP28 Gene

Sources for MMP28 Gene

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