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Aliases for MMP28 Gene

Aliases for MMP28 Gene

  • Matrix Metallopeptidase 28 2 3 5
  • EPILYSIN 3 4
  • MMP-28 3 4
  • MMP25 3 4
  • Matrix Metalloprotease MMP25 3
  • Matrix Metalloproteinase 28 2
  • Matrix Metalloproteinase-28 3
  • EC 3.4.24.- 4
  • MMP-25 3
  • MM28 3

External Ids for MMP28 Gene

Previous GeneCards Identifiers for MMP28 Gene

  • GC17M033862
  • GC17M036128
  • GC17M034238
  • GC17M031116
  • GC17M034092
  • GC17M030278

Summaries for MMP28 Gene

Entrez Gene Summary for MMP28 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for MMP28 Gene

MMP28 (Matrix Metallopeptidase 28) is a Protein Coding gene. Among its related pathways are Integrin Pathway and GPCR Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP28 Gene

  • Can degrade casein. Could play a role in tissues homeostasis and repair.

Tocris Summary for MMP28 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP28 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP28 Gene

Genomics for MMP28 Gene

Regulatory Elements for MMP28 Gene

Enhancers for MMP28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G035783 1.4 Ensembl ENCODE dbSUPER 9.2 +9.2 9223 6.9 TBP ZSCAN4 ZNF133 KLF17 RAD21 ZEB1 YY1 RCOR1 FOS CEBPB C17orf50 GAS2L2 TAF15 RASL10B MMP28 RDM1 HEATR9 GC17P035762
GH17G035725 1.1 Ensembl ENCODE 10.8 +69.2 69221 2.4 PKNOX1 NFIB FEZF1 ZNF48 ZNF366 SCRT2 ZNF350 ZNF263 CEBPB ZEB2 AP2B1 ZNF830 C17orf50 MMP28 LIG3 GAS2L2 RPL17P42 RASL10B
GH17G035712 1.1 Ensembl ENCODE 10.1 +82.1 82144 2.0 ELF3 SIN3A RAD21 RARA YY1 GATA4 GATA2 FOS CREM PPARG MMP28 AP2B1 LOC100420062 TAF15 PIR37925
GH17G035772 0.8 Ensembl ENCODE 12.4 +21.9 21935 1.7 ZBTB48 ZNF692 KLF17 PRDM10 ZNF398 MMP28 GAS2L2 TAF15 RASL10B GC17P035762
GH17G035807 1.1 ENCODE 9 -13.6 -13646 3.9 HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A LINC02001 C17orf50 GAS2L2 MMP28 HEATR9 RDM1 AP2B1 ENSG00000270829 ENSG00000270894
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP28 on UCSC Golden Path with GeneCards custom track

Promoters for MMP28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093518 107 401 SIN3A ZNF121 GLIS2 EGR1 KLF7 ZNF548 ZEB2 ZNF398 ZFP69B SMARCA4

Genomic Location for MMP28 Gene

Chromosome:
17
Start:
35,756,249 bp from pter
End:
35,795,707 bp from pter
Size:
39,459 bases
Orientation:
Minus strand

Genomic View for MMP28 Gene

Genes around MMP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP28 Gene

Proteins for MMP28 Gene

  • Protein details for MMP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H239-MMP28_HUMAN
    Recommended name:
    Matrix metalloproteinase-28
    Protein Accession:
    Q9H239
    Secondary Accessions:
    • Q96F04
    • Q96TE2

    Protein attributes for MMP28 Gene

    Size:
    520 amino acids
    Molecular mass:
    58939 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP28 Gene

Post-translational modifications for MMP28 Gene

Antibody Products

  • Abcam antibodies for MMP28

No data available for DME Specific Peptides for MMP28 Gene

Domains & Families for MMP28 Gene

Gene Families for MMP28 Gene

Suggested Antigen Peptide Sequences for MMP28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H239

UniProtKB/Swiss-Prot:

MMP28_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP28: view

Function for MMP28 Gene

Molecular function for MMP28 Gene

UniProtKB/Swiss-Prot Function:
Can degrade casein. Could play a role in tissues homeostasis and repair.

Enzyme Numbers (IUBMB) for MMP28 Gene

Gene Ontology (GO) - Molecular Function for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS 11121398
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP28: view
genes like me logo Genes that share phenotypes with MMP28: view

Animal Models for MMP28 Gene

MGI Knock Outs for MMP28:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP28

CRISPR Products

miRNA for MMP28 Gene

miRTarBase miRNAs that target MMP28

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP28 Gene

Localization for MMP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP28 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP28 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix NAS 11121398
GO:0005737 cytoplasm IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP28: view

Pathways & Interactions for MMP28 Gene

genes like me logo Genes that share pathways with MMP28: view

Pathways by source for MMP28 Gene

Interacting Proteins for MMP28 Gene

Gene Ontology (GO) - Biological Process for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010760 negative regulation of macrophage chemotaxis IEA --
genes like me logo Genes that share ontologies with MMP28: view

No data available for SIGNOR curated interactions for MMP28 Gene

Drugs & Compounds for MMP28 Gene

(6) Drugs for MMP28 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(1) Additional Compounds for MMP28 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP28 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP28: view

Transcripts for MMP28 Gene

Unigene Clusters for MMP28 Gene

Matrix metallopeptidase 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP28 Gene

No ASD Table

Relevant External Links for MMP28 Gene

GeneLoc Exon Structure for
MMP28
ECgene alternative splicing isoforms for
MMP28

Expression for MMP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP28 Gene

This gene is overexpressed in Testis (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP28 Gene



Protein tissue co-expression partners for MMP28 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP28 Gene:

MMP28

SOURCE GeneReport for Unigene cluster for MMP28 Gene:

Hs.380710

mRNA Expression by UniProt/SwissProt for MMP28 Gene:

Q9H239-MMP28_HUMAN
Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.

Evidence on tissue expression from TISSUES for MMP28 Gene

  • Lung(4.4)
  • Pancreas(4)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with MMP28: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP28 Gene

Orthologs for MMP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP28 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MMP28 34
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Mmp28 34 16
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia Mmp28 34
  • 84 (n)
cow
(Bos Taurus)
Mammalia MMP28 34
  • 78.61 (n)
chicken
(Gallus gallus)
Aves MMP28 34
  • 65.89 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp28 34
  • 58.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68506 34
zebrafish
(Danio rerio)
Actinopterygii LOC100005670 34
  • 59.53 (n)
Species where no ortholog for MMP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP28 Gene

ENSEMBL:
Gene Tree for MMP28 (if available)
TreeFam:
Gene Tree for MMP28 (if available)

Paralogs for MMP28 Gene

Paralogs for MMP28 Gene

(1) SIMAP similar genes for MMP28 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MMP28: view

Variants for MMP28 Gene

Sequence variations from dbSNP and Humsavar for MMP28 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000026322 -- 35,770,282(+) CGCGG(C/T)GGGGC nc-transcript-variant, reference, missense
rs1000041298 -- 35,785,733(+) TGAGC(C/T)ACCGC intron-variant
rs1000231544 -- 35,768,768(+) TCATG(A/C)CACTG intron-variant
rs1000355399 -- 35,782,263(+) TGTTA(C/G)CCAGG intron-variant
rs1000431161 -- 35,782,655(+) TGCAA(A/T)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP28 Gene

Variant ID Type Subtype PubMed ID
esv3640457 CNV gain 21293372
esv3892999 CNV loss 25118596

Variation tolerance for MMP28 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP28 Gene

Disorders for MMP28 Gene

Relevant External Links for MMP28

Human Genome Epidemiology (HuGE) Navigator
MMP28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP28

No disorders were found for MMP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP28 Gene

Publications for MMP28 Gene

  1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PMID: 11121398) Lohi J. … Parks W.C. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PMID: 11255011) Marchenko G.N. … Strongin A.Y. (Gene 2001) 2 3 4 22 64
  3. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PMID: 20144149) Swingler T.E. … Clark I.M. (Biochem. J. 2010) 3 22 64
  4. Expression and function of matrix metalloproteinase (MMP)-28. (PMID: 19375502) Rodgers U.R. … Clark I.M. (Matrix Biol. 2009) 3 22 64
  5. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PMID: 19379669) Heiskanen T.J. … Keski-Oja J. (Matrix Biol. 2009) 3 22 64

Products for MMP28 Gene

Sources for MMP28 Gene

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