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Aliases for MMP28 Gene

Aliases for MMP28 Gene

  • Matrix Metallopeptidase 28 2 3
  • EPILYSIN 3 4
  • MMP-28 3 4
  • MMP25 3 4
  • Matrix Metalloprotease MMP25 3
  • Matrix Metalloproteinase 28 2
  • Matrix Metalloproteinase-28 3
  • EC 3.4.24.- 4
  • MMP-25 3
  • MM28 3

External Ids for MMP28 Gene

Summaries for MMP28 Gene

Entrez Gene Summary for MMP28 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for MMP28 Gene

MMP28 (Matrix Metallopeptidase 28) is a Protein Coding gene. Diseases associated with MMP28 include asthma. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity.

UniProtKB/Swiss-Prot for MMP28 Gene

  • Can degrade casein. Could play a role in tissues homeostasis and repair

Tocris Summary for MMP28 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP28 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP28 Gene

Genomics for MMP28 Gene

Genomic Location for MMP28 Gene

Start:
35,756,249 bp from pter
End:
35,795,707 bp from pter
Size:
39,459 bases
Orientation:
Minus strand

Genomic View for MMP28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP28 Gene

Regulatory Elements for MMP28 Gene

Proteins for MMP28 Gene

  • Protein details for MMP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H239-MMP28_HUMAN
    Recommended name:
    Matrix metalloproteinase-28
    Protein Accession:
    Q9H239
    Secondary Accessions:
    • Q96F04
    • Q96TE2

    Protein attributes for MMP28 Gene

    Size:
    520 amino acids
    Molecular mass:
    58939 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP28 Gene

Proteomics data for MMP28 Gene at MOPED

Post-translational modifications for MMP28 Gene

Other Protein References for MMP28 Gene

No data available for DME Specific Peptides for MMP28 Gene

Domains for MMP28 Gene

UniProtKB/Swiss-Prot:

MMP28_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9H239
Family:
  • Belongs to the peptidase M10A family.:
    • Q9H239
Similarity:
  • Contains 4 hemopexin repeats.:
    • Q9H239
genes like me logo Genes that share domains with MMP28: view

Function for MMP28 Gene

Molecular function for MMP28 Gene

UniProtKB/Swiss-Prot Function: Can degrade casein. Could play a role in tissues homeostasis and repair

Enzyme Numbers (IUBMB) for MMP28 Gene

Gene Ontology (GO) - Molecular Function for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS 11121398
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP28: view

Phenotypes for MMP28 Gene

genes like me logo Genes that share phenotypes with MMP28: view

Animal Models for MMP28 Gene

MGI Knock Outs for MMP28:

miRNA for MMP28 Gene

miRTarBase miRNAs that target MMP28

No data available for Transcription Factor Targeting and HOMER Transcription for MMP28 Gene

Localization for MMP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP28 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP28 Gene COMPARTMENTS Subcellular localization image for MMP28 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 11121398
GO:0005737 cytoplasm IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP28: view

Pathways for MMP28 Gene

genes like me logo Genes that share pathways with MMP28: view

Interacting Proteins for MMP28 Gene

Selected Interacting proteins: Q9H239-MMP28_HUMAN for MMP28 Gene via I2D

Symbol External ID(s) Details
APPBP2
RAD54B

Gene Ontology (GO) - Biological Process for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010760 negative regulation of macrophage chemotaxis IEA --
genes like me logo Genes that share ontologies with MMP28: view

Compounds for MMP28 Gene

(5) Tocris Compounds for MMP28 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP28 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MMP28 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor
genes like me logo Genes that share compounds with MMP28: view

Transcripts for MMP28 Gene

Unigene Clusters for MMP28 Gene

Matrix metallopeptidase 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP28 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for MMP28 Gene

GeneLoc Exon Structure for
MMP28
ECgene alternative splicing isoforms for
MMP28

Expression for MMP28 Gene

mRNA expression in normal human tissues for MMP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MMP28 Gene

SOURCE GeneReport for Unigene cluster for MMP28 Gene Hs.380710

mRNA Expression by UniProt/SwissProt for MMP28 Gene

Q9H239-MMP28_HUMAN
Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin
genes like me logo Genes that share expressions with MMP28: view

Orthologs for MMP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP28 36
  • 78.61 (n)
  • 75.2 (a)
dog
(Canis familiaris)
Mammalia MMP28 36
  • 87.82 (n)
  • 88.27 (a)
mouse
(Mus musculus)
Mammalia Mmp28 36
  • 84.05 (n)
  • 85.29 (a)
Mmp28 16
rat
(Rattus norvegicus)
Mammalia Mmp28 36
  • 84 (n)
  • 84.86 (a)
chicken
(Gallus gallus)
Aves MMP28 36
  • 65.89 (n)
  • 61.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68506 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp28 36
  • 58.53 (n)
  • 58.46 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005670 36
  • 59.53 (n)
  • 55.03 (a)
Species with no ortholog for MMP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP28 Gene

ENSEMBL:
Gene Tree for MMP28 (if available)
TreeFam:
Gene Tree for MMP28 (if available)

Paralogs for MMP28 Gene

Selected SIMAP similar genes for MMP28 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MMP28: view

No data available for Paralogs for MMP28 Gene

Variants for MMP28 Gene

Sequence variations from dbSNP and Humsavar for MMP28 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs170501 -- 35,757,524(-) AGTTA(C/T)TAAGG intron-variant
rs226430 -- 35,787,244(-) GTTCT(G/T)GCTGT intron-variant
rs226431 -- 35,773,822(+) TGCAG(C/T)GTCAG intron-variant
rs1056414 -- 35,766,038(-) GCCCC(A/C)CCCCC utr-variant-3-prime, intron-variant
rs1056415 -- 35,766,002(-) ACAGG(C/G)GTCTC utr-variant-3-prime, intron-variant

Relevant External Links for MMP28 Gene

HapMap Linkage Disequilibrium report
MMP28

No data available for Structural Variations from Database of Genomic Variants (DGV) for MMP28 Gene

Disorders for MMP28 Gene

(1) MalaCards Diseases for MMP28 Gene

Search for MMP28 Gene in MalaCards »

(3) Novoseek inferred disease relationships for MMP28 Gene

Disease -log(P) Hits PubMed IDs
carcinoma 22.3 3
tumors 5.38 3
cancer 0 1

Relevant External Links for MMP28

Human Genome Epidemiology (HuGE) Navigator
MMP28
genes like me logo Genes that share disorders with MMP28: view

No data available for UniProtKB/Swiss-Prot for MMP28 Gene

Publications for MMP28 Gene

  1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PMID: 11121398) Lohi J. … Parks W.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PMID: 11255011) Marchenko G.N. … Strongin A.Y. (Gene 2001) 2 3 4 23
  3. Promoter characterization of the human and mouse epilysin (MMP-28) genes. (PMID: 11574168) Illman S.A. … Lohi J. (Gene 2001) 3 23
  4. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. (PMID: 12164918) Saarialho-Kere U. … Lohi J. (J. Invest. Dermatol. 2002) 3 23
  5. Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. (PMID: 15185874) Bister V.O. … Saarialho-Kere U. (Dig. Dis. Sci. 2004) 3 23

Products for MMP28 Gene

Sources for MMP28 Gene

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