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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP27 Gene

protein-coding   GIFtS: 55
GCID: GC11M102596

Matrix Metallopeptidase 27

(Previous name: matrix metalloproteinase 27)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 271 2     Matrix Metalloproteinase-272
Matrix Metalloproteinase 271 2     EC 3.4.24.-3
Matrix Metalloprotease 271 2     EC 3.4.248
MMP-272 3     EC 3.4.24.358

External Ids:    HGNC: 142501   Entrez Gene: 640662   Ensembl: ENSG000001376757   UniProtKB: Q9H3063   

Export aliases for MMP27 gene to outside databases

Previous GC identifers: GC11M104756 GC11M103919 GC11M102100 GC11M102067 GC11M098489


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP27 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP27 Gene: 
MMP27 (matrix metallopeptidase 27) is a protein-coding gene. Diseases associated with MMP27 include encephalomyelitis, and refractive error, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and GnRH Signaling. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
Function: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin,
laminin, gelatins and/or collagens (By similarity)

summary for MMP27 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP27 gene promoter:
         SRF   HFH-3   SRF (504 AA)   p300   Lmo2   XBP-1   CUTL1   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP27 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q24

MMP27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP27 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102596:  view genomic region     (about GC identifiers)

Start:
102,562,218 bp from pter      End:
102,576,537 bp from pter
Size:
14,320 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306 (See protein sequence)
Recommended Name: Matrix metalloproteinase-27 precursor  
Size: 513 amino acids; 59026 Da
Cofactor: Binds 4 calcium ions per subunit (By similarity)
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q6UWK6

Explore the universe of human proteins at neXtProt for MMP27: NX_Q9H306

Explore proteomics data for MMP27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H306

  • 4/10 DME Specific Peptides for MMP27 (Q9H306) (see all 10)
     LTFDAIT  VKKIDAA  IHTLGFP  PRCGVPD 

    MMP27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MMP27 Protein Expression
    REFSEQ proteins: NP_071405.2  
    ENSEMBL proteins: 
     ENSP00000260229  

    Human Recombinant Protein Products for MMP27: 
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    Cloud-Clone Corp. Proteins for MMP27 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    MMP27 for ontologies           About GeneDecksing



    MMP27 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MMP27 

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    Cloud-Clone Corp. ELISAs for MMP27 
    Cloud-Clone Corp. CLIAs for MMP27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP27 
    Cell-surface protein and extracellular matrix metalloproteinases

    5/10 InterPro protein domains (see all 10):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry Q9H306

    ProtoNet protein and cluster: Q9H306

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP27_HUMAN, Q9H306
    Function: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin,
    laminin, gelatins and/or collagens (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.352 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP27 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Mmp27 (no phenotypes)

    MMP27 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp27tm1Lex for MMP27

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MMP27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MMP27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP27 
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                         Customized lentivirus expression plasmids for stable overexpression of MMP27 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MMP27 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP27
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP27
        Matrix Metalloproteinases


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMP27

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0030574collagen catabolic process IEA--

    MMP27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for MMP27:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP27 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP27    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP27    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    Search CenterWatch for drugs/clinical trials and news about MMP27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MMP27 gene: 
    NM_022122.2  

    Unigene Cluster for MMP27:

    Matrix metallopeptidase 27
    Hs.534479  [show with all ESTs]
    Unigene Representative Sequence: AF195192
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260229(uc001phd.1)
    miRNA
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    OriGene qSTAR qPCR primer pairs in human, mouse for MMP27
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP27

    Additional mRNA sequence: 

    AF195192.1 AY358752.1 

    1 DOTS entry:

    DT.40119350 

    9 AceView cDNA sequences:

    BX102293 AA424347 BG189775 AF195192 AY358752 AA424513 AI436025 NM_022122 
    AI273586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGACCC
    MMP27 Expression
    About this image


    See MMP27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP27

    SOURCE GeneReport for Unigene cluster: Hs.534479

    UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
    Tissue specificity: Expressed in B-cells

        SABiosciences Custom PCR Arrays for MMP27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MMP27 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp271 , 5 matrix metallopeptidase 271, 5 81.76(n)1
    77.17(a)1
      9 (2.46 cM)5
    2349111  NM_001030289.11  NP_001025460.11 
     75713965 
    chicken
    (Gallus gallus)
    Aves MMP271 matrix metallopeptidase 27 65.73(n)
    59.14(a)
      395850  NM_205000.1  NP_990331.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP276
    matrix metallopeptidase 27
    50(a)
    1 ↔ 1
    3(192164557-192179606)
    zebrafish
    (Danio rerio)
    Actinopterygii mmp13a6
    matrix metalloproteinase 13a
    43(a)
    1 → many
    10(39959934-39979810)


    ENSEMBL Gene Tree for MMP27 (if available)
    TreeFam Gene Tree for MMP27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP27 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP112  MMP172  MMP102  MMP12  
    13 SIMAP similar genes for MMP27 using alignment to 1 protein entry:     MMP27_HUMAN:
    MMP8    MMP1    MMP3    MMP13    MMP10    MMP12
    MMP7    MMP20    MMP26    MMP14    MMP16    MMP19
    MMP24

    MMP27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 SNPs in MMP27 are shown (see all 526)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390153781,2
    Cuntested1102575416(+) CATTTC/TCCGAA 2 K E mis11Minor allele frequency- T:0.00NA 4546
    rs1862930541,2
    --102561951(+) AGTGTA/GCAGAA 1 -- ds50010--------
    rs1467580961,2
    C--102561966(+) TAATTG/TTATAT 1 -- ds50010--------
    rs108953491,2
    C,F,A,H--102561975(+) ATTCCC/TTAAGG 1 -- ds50016Minor allele frequency- T:0.19NA EA 250
    rs27019631,2
    C,F,A,H--102561980(-) ACATTC/TCTTAG 1 -- ds500124Minor allele frequency- T:0.38NS EA NA CSA WA 2718
    rs28467061,2
    C,F,H--102561994(-) ACCAAC/AGCCGT 1 -- ds50016Minor allele frequency- A:0.07NS EA WA NA 658
    rs28463561,2
    C,F,H--102562075(-) GTTACG/ATTAGA 1 -- ds50015Minor allele frequency- A:0.05NS EA NA 540
    rs1910665271,2
    --102562320(+) TCAGAG/TATTTT 1 -- ds50010--------
    rs751337121,2
    C,F--102562335(+) TCTACG/ATAATA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1169673101,2
    F--102562336(+) CTACAT/CAATAA 1 -- ds50011Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for MMP27 (102562218 - 102576537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MMP27:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660550CNV Deletion23128226
    nsv819435CNV Loss19587683
    nsv832252CNV Gain17160897

    1 SABiosciences Cancer Mutation PCR Assay for MMP27:
    Cosmic IdAA Change
    108797p.E25K
    SeqTarget long-range PCR primers for resequencing MMP27
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for MMP27:    About MalaCards
    encephalomyelitis    refractive error    arthritis    multiple sclerosis
    adenocarcinoma    pancreatitis


    MMP27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MMP27
    Human Genome Epidemiology (HuGE) Navigator: MMP27 (4 documents)

    Export disorders for MMP27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP27 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MMP27)
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    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Matrix metalloproteinases. (PubMed id 10419448)1, 3 Nagase H. and Woessner J.F. (1999)
    4. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    5. Association of matrix metalloproteinase gene polymorp hisms with refractive error in Amish and Ashkenazi families. (PubMed id 20484597)1 Wojciechowski R....Stambolian D. (2010)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. (PubMed id 14506071)2 Bar-Or A.... Yong V.W. (2003)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Clinical potential of matrix metalloprotease inhibito rs in cancer therapy. (PubMed id 10852638)7 Heath E.I. and Grochow L.B. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64066 HGNC: 14250 AceView: MMP27 Ensembl:ENSG00000137675 euGenes: HUgn64066
    ECgene: MMP27 H-InvDB: MMP27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP27 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP27 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MMP27 gene:
    Search GeneIP for patents involving MMP27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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