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Aliases for MMP27 Gene

Aliases for MMP27 Gene

  • Matrix Metallopeptidase 27 2 3 5
  • Matrix Metalloprotease 27 2 3
  • MMP-27 3 4
  • Matrix Metalloproteinase 27 2
  • Matrix Metalloproteinase-27 3
  • EC 3.4.24.35 61
  • EC 3.4.24.- 4
  • EC 3.4.24 61

External Ids for MMP27 Gene

Previous GeneCards Identifiers for MMP27 Gene

  • GC11M104756
  • GC11M103919
  • GC11M102100
  • GC11M102067
  • GC11M098489

Summaries for MMP27 Gene

Entrez Gene Summary for MMP27 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP27 Gene

MMP27 (Matrix Metallopeptidase 27) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.

UniProtKB/Swiss-Prot for MMP27 Gene

  • Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Tocris Summary for MMP27 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP27 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP27 Gene

Genomics for MMP27 Gene

Regulatory Elements for MMP27 Gene

Enhancers for MMP27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F102727 1.4 FANTOM5 Ensembl ENCODE 19.1 -22.4 -22395 1.6 SOX13 HDGF PKNOX1 JUN BACH1 ZNF664 FOSL1 ZNF316 FOSL2 NFE2 MMP27 MMP10 MMP1 MMP3 RNU7-159P BIRC2 TMEM123 BIRC3 MMP8 WTAPP1
GH11F102729 0.9 Ensembl ENCODE 17.9 -24.5 -24532 1.9 SOX13 JUN BACH1 TEAD3 RARA FOSL1 ZNF366 CREM EGR2 GATAD2A MMP27 MMP10 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11F102733 0.5 ENCODE 10.5 -27.6 -27639 0.2 SCRT1 CTCF ZNF654 PKNOX1 TRIM22 REST RAD21 KLF16 SCRT2 PBX2 MMP10 MMP27 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11F103055 0.2 ENCODE 9.4 -349.6 -349581 0.1 CTCF ZNF654 ZNF143 SMC3 TRIM22 RAD21 ZBTB40 MMP13 MMP27 ENSG00000260966 GC11P103046
GH11F103056 0.6 ENCODE 9.4 -349.8 -349801 0.2 CTCF TRIM22 ZBTB40 MMP13 MMP27 ENSG00000260966 GC11P103046
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MMP27 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP27 Gene

Chromosome:
11
Start:
102,691,487 bp from pter
End:
102,705,806 bp from pter
Size:
14,320 bases
Orientation:
Minus strand

Genomic View for MMP27 Gene

Genes around MMP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP27 Gene

Proteins for MMP27 Gene

  • Protein details for MMP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H306-MMP27_HUMAN
    Recommended name:
    Matrix metalloproteinase-27
    Protein Accession:
    Q9H306
    Secondary Accessions:
    • Q6UWK6

    Protein attributes for MMP27 Gene

    Size:
    513 amino acids
    Molecular mass:
    59026 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP27 Gene

Selected DME Specific Peptides for MMP27 Gene

Post-translational modifications for MMP27 Gene

Other Protein References for MMP27 Gene

Domains & Families for MMP27 Gene

Gene Families for MMP27 Gene

Suggested Antigen Peptide Sequences for MMP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H306

UniProtKB/Swiss-Prot:

MMP27_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP27: view

Function for MMP27 Gene

Molecular function for MMP27 Gene

UniProtKB/Swiss-Prot Function:
Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Enzyme Numbers (IUBMB) for MMP27 Gene

Gene Ontology (GO) - Molecular Function for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP27: view
genes like me logo Genes that share phenotypes with MMP27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP27

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MMP27 Gene

Localization for MMP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP27 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the endoplasmic reticulum. {ECO:0000269 PubMed:24548619}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP27 Gene COMPARTMENTS Subcellular localization image for MMP27 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0031012 extracellular matrix IEA --
GO:0042406 extrinsic component of endoplasmic reticulum membrane IDA 24548619
genes like me logo Genes that share ontologies with MMP27: view

Pathways & Interactions for MMP27 Gene

genes like me logo Genes that share pathways with MMP27: view

Pathways by source for MMP27 Gene

Gene Ontology (GO) - Biological Process for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030574 collagen catabolic process IEA --
genes like me logo Genes that share ontologies with MMP27: view

No data available for SIGNOR curated interactions for MMP27 Gene

Drugs & Compounds for MMP27 Gene

(6) Drugs for MMP27 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(1) Additional Compounds for MMP27 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP27 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP27: view

Transcripts for MMP27 Gene

mRNA/cDNA for MMP27 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP27 Gene

Matrix metallopeptidase 27:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP27 Gene

No ASD Table

Relevant External Links for MMP27 Gene

GeneLoc Exon Structure for
MMP27
ECgene alternative splicing isoforms for
MMP27

Expression for MMP27 Gene

mRNA expression in normal human tissues for MMP27 Gene

mRNA differential expression in normal tissues according to GTEx for MMP27 Gene

This gene is overexpressed in Minor Salivary Gland (x10.9), Skin - Sun Exposed (Lower leg) (x10.6), Skin - Not Sun Exposed (Suprapubic) (x8.5), and Adipose - Subcutaneous (x6.5).

Protein differential expression in normal tissues from HIPED for MMP27 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP27 Gene



Protein tissue co-expression partners for MMP27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP27 Gene:

MMP27

SOURCE GeneReport for Unigene cluster for MMP27 Gene:

Hs.534479

mRNA Expression by UniProt/SwissProt for MMP27 Gene:

Q9H306-MMP27_HUMAN
Tissue specificity: Expressed in B-cells (PubMed:14506071). Expressed in a subset of endometrial macrophages related to menstruation and in ovarian and peritoneal endometriotic lesions (at protein level)(PubMed:24810263).
genes like me logo Genes that share expression patterns with MMP27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MMP27 Gene

Orthologs for MMP27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP27 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia MMP27 34 35
  • 86.59 (n)
cow
(Bos Taurus)
Mammalia MMP27 34 35
  • 85.96 (n)
mouse
(Mus musculus)
Mammalia Mmp27 34 16 35
  • 81.76 (n)
rat
(Rattus norvegicus)
Mammalia Mmp27 34
  • 81.44 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP27 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP27 34 35
  • 65.73 (n)
lizard
(Anolis carolinensis)
Reptilia MMP27 35
  • 51 (a)
OneToOne
Species where no ortholog for MMP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP27 Gene

ENSEMBL:
Gene Tree for MMP27 (if available)
TreeFam:
Gene Tree for MMP27 (if available)

Paralogs for MMP27 Gene

(13) SIMAP similar genes for MMP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP27: view

Variants for MMP27 Gene

Sequence variations from dbSNP and Humsavar for MMP27 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10708640 -- 102,698,475(+) ATATT(-/A)AAAAA intron-variant
rs10895348 -- 102,690,957(+) TTGAC(A/G)TAATG utr-variant-3-prime
rs10895349 -- 102,691,244(+) ATTCC(C/T)TAAGG downstream-variant-500B, utr-variant-3-prime
rs10895351 -- 102,695,125(+) TACAC(A/T)TGCAG intron-variant
rs10895352 -- 102,695,681(+) ATGGG(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP27 Gene

Variant ID Type Subtype PubMed ID
esv2660550 CNV deletion 23128226
esv3627535 CNV loss 21293372
nsv819435 CNV loss 19587683
nsv832252 CNV gain 17160897

Variation tolerance for MMP27 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.73; 93.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP27 Gene

Disorders for MMP27 Gene

Relevant External Links for MMP27

Genetic Association Database (GAD)
MMP27
Human Genome Epidemiology (HuGE) Navigator
MMP27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP27

No disorders were found for MMP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP27 Gene

Publications for MMP27 Gene

  1. A unique C-terminal domain allows retention of matrix metalloproteinase-27 in the endoplasmic reticulum. (PMID: 24548619) Cominelli A. … Henriet P. (Traffic 2014) 3 4 64
  2. Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions. (PMID: 24810263) Cominelli A. … Henriet P. (Mol. Hum. Reprod. 2014) 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Matrix metalloproteinases. (PMID: 10419448) Nagase H. … Woessner J.F. (J. Biol. Chem. 1999) 2 3 64

Products for MMP27 Gene

Sources for MMP27 Gene

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