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MMP27 Gene

protein-coding   GIFtS: 53
GCID: GC11M102596

Matrix Metallopeptidase 27

(Previous name: matrix metalloproteinase 27)
  See MMP27-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 271 2     Matrix Metalloproteinase-272
Matrix Metalloproteinase 271 2     EC 3.4.24.-3
Matrix Metalloprotease 271 2     EC 3.4.248
MMP-272 3     EC 3.4.24.358

External Ids:    HGNC: 142501   Entrez Gene: 640662   Ensembl: ENSG000001376757   UniProtKB: Q9H3063   

Export aliases for MMP27 gene to outside databases

Previous GC identifers: GC11M104756 GC11M103919 GC11M102100 GC11M102067 GC11M098489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP27 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP27 Gene:
MMP27 (matrix metallopeptidase 27) is a protein-coding gene. Diseases associated with MMP27 include encephalomyelitis, and arthritis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
Function: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin,
laminin, gelatins and/or collagens (By similarity)

summary for MMP27 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP27 gene promoter:
         SRF   HFH-3   SRF (504 AA)   p300   Lmo2   XBP-1   CUTL1   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP27 promoter sequence
   Search Chromatin IP Primers for MMP27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q24

MMP27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP27 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102596:  view genomic region     (about GC identifiers)

Start:
102,562,218 bp from pter      End:
102,576,537 bp from pter
Size:
14,320 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306 (See protein sequence)
Recommended Name: Matrix metalloproteinase-27 precursor  
Size: 513 amino acids; 59026 Da
Cofactor: Binds 4 calcium ions per subunit (By similarity)
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Secondary accessions: Q6UWK6

Explore the universe of human proteins at neXtProt for MMP27: NX_Q9H306

Explore proteomics data for MMP27 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn110
  • Selected DME Specific Peptides for MMP27 (Q9H306) (see all 10)
     LTFDAIT  VKKIDAA  IHTLGFP  PRCGVPD 


    See MMP27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071405.2  
    ENSEMBL proteins: 
     ENSP00000260229  

    MMP27 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MMP27

     
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    antibodies-online proteins for MMP27 (2 products) 

     
    antibodies-online peptides for MMP27

    MMP27 Antibody Products:

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    antibodies-online antibodies for MMP27 (23 products) 

    MMP27 Assay Products:

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    antibodies-online kits for MMP27 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP27
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry Q9H306

    ProtoNet protein and cluster: Q9H306

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP27_HUMAN, Q9H306
    Function: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin,
    laminin, gelatins and/or collagens (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.352 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP27           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Mmp27 (no phenotypes)

    Find genes that share phenotypes with MMP27           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmp27tm1Lex for MMP27

       genOway: Develop your customized and physiologically relevant rodent model for MMP27

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP27


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP27_HUMAN, Q9H306: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular2
    plasma membrane2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MMP27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP27 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP27
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP27
        Matrix Metalloproteinases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP27
    Interactions:

        Search GeneGlobe Interaction Network for MMP27

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0030574collagen catabolic process IEA--

    Find genes that share ontologies with MMP27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP27 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP27    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP27    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP27 gene: 
    NM_022122.2  

    Unigene Cluster for MMP27:

    Matrix metallopeptidase 27
    Hs.534479  [show with all ESTs]
    Unigene Representative Sequence: AF195192
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260229(uc001phd.1)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP27
      QuantiTect SYBR Green Assays in human, mouse, rat MMP27
      QuantiFast Probe-based Assays in human, mouse, rat MMP27

    Additional mRNA sequence: 

    AF195192.1 AY358752.1 

    1 DOTS entry:

    DT.40119350 

    9 AceView cDNA sequences:

    BX102293 AA424347 NM_022122 AF195192 AY358752 AI436025 BG189775 AA424513 
    AI273586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGACCC
    MMP27 Expression
    About this image

    MMP27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534479

    UniProtKB/Swiss-Prot: MMP27_HUMAN, Q9H306
    Tissue specificity: Expressed in B-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP27 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp271 , 5 matrix metallopeptidase 271, 5 81.76(n)1
    77.17(a)1
      9 (2.46 cM)5
    2349111  NM_001030289.11  NP_001025460.11 
     75713965 
    chicken
    (Gallus gallus)
    Aves MMP271 matrix metallopeptidase 27 65.73(n)
    59.14(a)
      395850  NM_205000.1  NP_990331.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP276
    matrix metallopeptidase 27
    51(a)
    1 ↔ 1
    3(192164557-192179606)


    ENSEMBL Gene Tree for MMP27 (if available)
    TreeFam Gene Tree for MMP27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP27 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP112  MMP172  MMP102  MMP12  
    13 SIMAP similar genes for MMP27 using alignment to 1 protein entry:     MMP27_HUMAN:
    MMP8    MMP1    MMP3    MMP13    MMP10    MMP12
    MMP7    MMP20    MMP26    MMP14    MMP16    MMP19
    MMP24

    Find genes that share paralogs with MMP27           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP27 (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390153781,2
    Cuntested1102575416(+) CATTTC/TCCGAA 2 K E mis11Minor allele frequency- T:0.00NA 4546
    rs1862930541,2
    --102561951(+) AGTGTA/GCAGAA 1 -- ds50010--------
    rs1467580961,2
    C--102561966(+) TAATTG/TTATAT 1 -- ds50010--------
    rs108953491,2
    C,F,A,H--102561975(+) ATTCCC/TTAAGG 1 -- ds50016Minor allele frequency- T:0.19NA EA 250
    rs27019631,2
    C,F,A,H--102561980(-) ACATTC/TCTTAG 1 -- ds500124Minor allele frequency- T:0.38NS EA NA CSA WA 2718
    rs28467061,2
    C,F,H--102561994(-) ACCAAC/AGCCGT 1 -- ds50016Minor allele frequency- A:0.07NS EA WA NA 658
    rs28463561,2
    C,F,H--102562075(-) GTTACG/ATTAGA 1 -- ds50015Minor allele frequency- A:0.05NS EA NA 540
    rs1910665271,2
    --102562320(+) TCAGAG/TATTTT 1 -- ds50010--------
    rs751337121,2
    C,F--102562335(+) TCTACG/ATAATA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1169673101,2
    F--102562336(+) CTACAT/CAATAA 1 -- ds50011Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for MMP27 (102562218 - 102576537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MMP27:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660550CNV Deletion23128226
    nsv819435CNV Loss19587683
    nsv832252CNV Gain17160897

    1 Site Specific Mutation Identification with PCR Assay for MMP27:
    Cosmic IdAA Change
    108797p.E25K
    SeqTarget long-range PCR primers for resequencing MMP27
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for MMP27:    
    About MalaCards
    encephalomyelitis    arthritis


    Find genes that share disorders with MMP27           About GenesLikeMe

    Genetic Association Database (GAD): MMP27
    Human Genome Epidemiology (HuGE) Navigator: MMP27 (4 documents)

    Export disorders for MMP27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP27 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MMP27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Matrix metalloproteinases. (PubMed id 10419448)1, 3 Nagase H. and Woessner J.F. (J. Biol. Chem. 1999)
    4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    5. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. (PubMed id 20484597)1 Wojciechowski R....Stambolian D. (amp 2010)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    8. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. (PubMed id 14506071)2 Bar-Or A.... Yong V.W. (Brain 2003)
    9. Clinical potential of matrix metalloprotease inhibitors in cancer therapy. (PubMed id 10852638)7 Heath E.I. and Grochow L.B. (Drugs 2000)
    10. MMP inhibitors: experimental and clinical studies. (PubMed id 10669951)7 Belotti D....Giavazzi R. (Int. J. Biol. Markers 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64066 HGNC: 14250 AceView: MMP27 Ensembl:ENSG00000137675 euGenes: HUgn64066
    ECgene: MMP27 H-InvDB: MMP27

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP27 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP27 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP27 gene:
    Search GeneIP for patents involving MMP27

    GeneCards and IP:
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