Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MMP26 Gene

Aliases for MMP26 Gene

  • Matrix Metallopeptidase 26 2 3 5
  • Matrilysin 2 2 3
  • Endometase 3 4
  • MMP-26 3 4
  • Matrix Metalloproteinase 26 2
  • Matrix Metalloproteinase-26 3
  • Matrilysin-2 4
  • EC 3.4.24.- 4

External Ids for MMP26 Gene

Previous GeneCards Identifiers for MMP26 Gene

  • GC11P005575
  • GC11P005311
  • GC11P004968
  • GC11P004973
  • GC11P004966
  • GC11P004745
  • GC11P004726
  • GC11P004669

Summaries for MMP26 Gene

Entrez Gene Summary for MMP26 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

GeneCards Summary for MMP26 Gene

MMP26 (Matrix Metallopeptidase 26) is a Protein Coding gene. Diseases associated with MMP26 include Endometrial Cancer. Among its related pathways are GPCR Pathway and Matrix Metalloproteinases. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP26 Gene

  • May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Tocris Summary for MMP26 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP26 Gene

Additional gene information for MMP26 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP26 Gene

Genomics for MMP26 Gene

Regulatory Elements for MMP26 Gene

Enhancers for MMP26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H005328 0.3 FANTOM5 4 +624.3 624252 0 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
GH11H005379 0.3 FANTOM5 2.6 +675.1 675065 0 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP26 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP26 Gene

Chromosome:
11
Start:
4,704,927 bp from pter
End:
4,992,429 bp from pter
Size:
287,503 bases
Orientation:
Plus strand

Genomic View for MMP26 Gene

Genes around MMP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP26 Gene

Proteins for MMP26 Gene

  • Protein details for MMP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRE1-MMP26_HUMAN
    Recommended name:
    Matrix metalloproteinase-26
    Protein Accession:
    Q9NRE1
    Secondary Accessions:
    • Q3MJ78
    • Q9GZS2
    • Q9NR87

    Protein attributes for MMP26 Gene

    Size:
    261 amino acids
    Molecular mass:
    29708 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP26 Gene

Post-translational modifications for MMP26 Gene

  • Glycosylation at Asn64 and Asn221
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMP26 Gene

Domains & Families for MMP26 Gene

Gene Families for MMP26 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRE1

UniProtKB/Swiss-Prot:

MMP26_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP26: view

Function for MMP26 Gene

Molecular function for MMP26 Gene

UniProtKB/Swiss-Prot Function:
May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Enzyme Numbers (IUBMB) for MMP26 Gene

Phenotypes From GWAS Catalog for MMP26 Gene

Gene Ontology (GO) - Molecular Function for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP26: view
genes like me logo Genes that share phenotypes with MMP26: view

Animal Model Products

CRISPR Products

miRNA for MMP26 Gene

miRTarBase miRNAs that target MMP26

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MMP26
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP26 Gene

Localization for MMP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP26 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP26 gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix NAS 10801841
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP26 Gene

Pathways & Interactions for MMP26 Gene

genes like me logo Genes that share pathways with MMP26: view

Pathways by source for MMP26 Gene

1 GeneTex pathway for MMP26 Gene
1 BioSystems pathway for MMP26 Gene

Gene Ontology (GO) - Biological Process for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10987280
GO:0030574 collagen catabolic process IEA --
GO:0050728 negative regulation of inflammatory response IMP 23569462
genes like me logo Genes that share ontologies with MMP26: view

No data available for SIGNOR curated interactions for MMP26 Gene

Drugs & Compounds for MMP26 Gene

(10) Drugs for MMP26 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(3) Additional Compounds for MMP26 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP26 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP26: view

Transcripts for MMP26 Gene

mRNA/cDNA for MMP26 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP26 Gene

Matrix metallopeptidase 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MMP26
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MMP26 Gene

No ASD Table

Relevant External Links for MMP26 Gene

GeneLoc Exon Structure for
MMP26
ECgene alternative splicing isoforms for
MMP26

Expression for MMP26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP26 Gene

mRNA differential expression in normal tissues according to GTEx for MMP26 Gene

This gene is overexpressed in Uterus (x26.4), Prostate (x17.0), and Testis (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of MMP26 Gene:

MMP26

SOURCE GeneReport for Unigene cluster for MMP26 Gene:

Hs.204732

mRNA Expression by UniProt/SwissProt for MMP26 Gene:

Q9NRE1-MMP26_HUMAN
Tissue specificity: Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

Evidence on tissue expression from TISSUES for MMP26 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with MMP26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP26 Gene

Orthologs for MMP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP26 33 34
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia MMP26 33 34
  • 78.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii MMP26 34
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 34
  • 13 (a)
ManyToMany
zmp-1 34
  • 9 (a)
ManyToMany
Species where no ortholog for MMP26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMP26 Gene

ENSEMBL:
Gene Tree for MMP26 (if available)
TreeFam:
Gene Tree for MMP26 (if available)

Paralogs for MMP26 Gene

Paralogs for MMP26 Gene

(18) SIMAP similar genes for MMP26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP26: view

Variants for MMP26 Gene

Sequence variations from dbSNP and Humsavar for MMP26 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000150058 -- 4,988,081(+) GATGA(C/T)GCCAC upstream-variant-2KB
rs1002020165 -- 4,988,611(+) CACTC(C/T)AGTAT intron-variant
rs1003427627 -- 4,987,305(+) TCAAT(A/G)CTTTG upstream-variant-2KB
rs1003554410 -- 4,987,806(+) TTTTT(A/G)GCTTC upstream-variant-2KB
rs1003586995 -- 4,988,039(+) CACCC(C/T)TGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP26 Gene

Variant ID Type Subtype PubMed ID
esv2759799 CNV loss 17122850
esv2760169 CNV gain+loss 21179565
nsv1054847 CNV gain 25217958
nsv510237 OTHER sequence alteration 20534489
nsv526998 CNV loss 19592680

Variation tolerance for MMP26 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP26 Gene

Disorders for MMP26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP26 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search MMP26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP26

Genetic Association Database (GAD)
MMP26
Human Genome Epidemiology (HuGE) Navigator
MMP26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP26
genes like me logo Genes that share disorders with MMP26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP26 Gene

Publications for MMP26 Gene

  1. Cloning of MMP-26. A novel matrilysin-like proteinase. (PMID: 10824119) de Coignac AB … Gauchat JF (European journal of biochemistry 2000) 2 3 4 22 60
  2. Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. (PMID: 10801841) Park HI … Sang QX (The Journal of biological chemistry 2000) 2 3 4 22 60
  3. Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin. (PMID: 11389678) Marchenko GN … Strongin AY (The Biochemical journal 2001) 3 4 22 60
  4. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. (PMID: 10987280) Uría JA … López-Otín C (Cancer research 2000) 3 4 22 60
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 45 60

Products for MMP26 Gene

Sources for MMP26 Gene

Content
Loading form....