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Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3 5
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MT6-MMP 3 4
  • MMP-25 3 4
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Membrane-Type-6 Matrix Metalloproteinase 4
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 25 2
  • Matrix Metalloproteinase 20 3
  • Matrix Metalloproteinase-25 3
  • EC 3.4.24.- 4
  • MT-MMP6 3
  • MMP20A 3

External Ids for MMP25 Gene

Previous HGNC Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Previous GeneCards Identifiers for MMP25 Gene

  • GC16U990147
  • GC16P003130
  • GC16P003097
  • GC16P003100
  • GC16P003102
  • GC16P003037
  • GC16P003038
  • GC16P003106
  • GC16P003108
  • GC16P003068
  • GC16P003109
  • GC16P003111
  • GC16P003127
  • GC16P003151
  • GC16P003139
  • GC16P003149
  • GC16P003235
  • GC16P003291

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Among its related pathways are Immune System and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP17.

UniProtKB/Swiss-Prot for MMP25 Gene

  • May activate progelatinase A.

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP25 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

Regulatory Elements for MMP25 Gene

Enhancers for MMP25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003004 1.5 FANTOM5 ENCODE 49.3 -37.9 -37878 7.9 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MMP25 LOC107984895 CREBBP ZNF597 THOC6 ZNF263 LOC105371055 SNORD60 BICDL2 CLDN9
GH16F003052 1.3 Ensembl ENCODE 29.9 +8.6 8638 4.4 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF207 KLF13 ZNF263 SP3 MMP25 BICDL2 IL32 CLDN6 TNFRSF12A ZNF205 CLDN9 PKMYT1 GC16P003092
GH16F003254 1.7 FANTOM5 Ensembl ENCODE 21.6 +211.4 211435 6.8 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 YY1 ZNF766 ELK1 CBX5 MEFV MMP25 ZNF263 CREBBP ZNF75A LOC105371055 ZNF597 ZNF200 THOC6 OR2C1
GH16F003069 1.7 FANTOM5 Ensembl ENCODE 21.3 +28.4 28417 9.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 LOC105371058 MMP25 IL32 ZNF205 BICDL2 LOC100128770 CLDN6 THOC6 HCFC1R1 TNFRSF12A
GH16F003063 1.4 FANTOM5 ENCODE 14.6 +20.1 20095 5.8 HDGF PKNOX1 ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF121 IL32 MMP25 LOC105371058 ZNF597 CREBBP BICDL2 ZSCAN10 LOC100128770 LOC107984895 ENSG00000260447
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP25 on UCSC Golden Path with GeneCards custom track

Promoters for MMP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001799078 237 2001 SIN3A RAD21 GLIS2 ZNF143 ZNF548 EGR2 SMARCA5 ZNF362 SP3 ELF1

Genomic Location for MMP25 Gene

Chromosome:
16
Start:
3,045,963 bp from pter
End:
3,060,729 bp from pter
Size:
14,767 bases
Orientation:
Plus strand

Genomic View for MMP25 Gene

Genes around MMP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA2-MMP25_HUMAN
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Q9NPA2
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    Size:
    562 amino acids
    Molecular mass:
    62554 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

Antibody Products

  • R&D Systems Antibodies for MMP25 (MMP-25/MT6-MMP)
  • Abcam antibodies for MMP25

No data available for DME Specific Peptides for MMP25 Gene

Domains & Families for MMP25 Gene

Gene Families for MMP25 Gene

Suggested Antigen Peptide Sequences for MMP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA2

UniProtKB/Swiss-Prot:

MMP25_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function:
May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP25: view
genes like me logo Genes that share phenotypes with MMP25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP25

miRNA for MMP25 Gene

miRTarBase miRNAs that target MMP25

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix NAS 10628838
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MMP25: view

Pathways & Interactions for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

Pathways by source for MMP25 Gene

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 10706098
GO:0006954 inflammatory response IEA,NAS 10628838
GO:0060022 hard palate development IEA --
genes like me logo Genes that share ontologies with MMP25: view

No data available for SIGNOR curated interactions for MMP25 Gene

Drugs & Compounds for MMP25 Gene

(6) Drugs for MMP25 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(1) Additional Compounds for MMP25 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP25 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

Unigene Clusters for MMP25 Gene

Matrix metallopeptidase 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
MMP25
ECgene alternative splicing isoforms for
MMP25

Expression for MMP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (x46.5).

NURSA nuclear receptor signaling pathways regulating expression of MMP25 Gene:

MMP25

SOURCE GeneReport for Unigene cluster for MMP25 Gene:

Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene:

Q9NPA2-MMP25_HUMAN
Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
genes like me logo Genes that share expression patterns with MMP25: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MMP25 Gene

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP25 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia MMP25 34 35
  • 85.63 (n)
dog
(Canis familiaris)
Mammalia MMP25 34 35
  • 83.36 (n)
mouse
(Mus musculus)
Mammalia Mmp25 34 16 35
  • 79.43 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP25 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP25 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP25 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp25 34
  • 56.21 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333601 34
  • 52.71 (n)
CABZ01030094.1 35
  • 44 (a)
OneToMany
MMP25 (2 of 2) 35
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 34
  • 51.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 36
  • 36 (a)
Mmp1 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for MMP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP25 Gene

ENSEMBL:
Gene Tree for MMP25 (if available)
TreeFam:
Gene Tree for MMP25 (if available)

Paralogs for MMP25 Gene

(11) SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Sequence variations from dbSNP and Humsavar for MMP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1004792 -- 3,044,260(+) CATCC(A/G)tttct upstream-variant-2KB
rs10431961 -- 3,050,094(+) CGTCG(C/T)CGGTA reference, synonymous-codon
rs1043298 -- 3,060,521(+) AACCA(A/T)GCGAG upstream-variant-2KB, utr-variant-3-prime
rs10438592 -- 3,060,094(+) AGGCC(C/T)TAGCT upstream-variant-2KB, utr-variant-3-prime
rs10438593 -- 3,060,713(+) AAAAA(C/T)GAATG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
nsv952907 CNV deletion 24416366
nsv833125 CNV loss 17160897
nsv571248 CNV loss 21841781
nsv509589 CNV insertion 20534489
nsv1115893 CNV deletion 24896259
esv3637647 CNV gain 21293372
esv3637646 CNV loss 21293372
esv3637645 CNV gain 21293372
esv3581939 CNV loss 25503493
esv2763127 CNV loss 21179565
esv2750392 CNV deletion 23290073
esv2750390 CNV deletion 23290073
dgv323e201 CNV deletion 23290073

Variation tolerance for MMP25 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP25 Gene

Disorders for MMP25 Gene

Relevant External Links for MMP25

Genetic Association Database (GAD)
MMP25
Human Genome Epidemiology (HuGE) Navigator
MMP25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP25

No disorders were found for MMP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D.Q. (Cell Res. 1999) 2 3 4 22 64
  2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PMID: 10706098) Velasco G. … Lopez-Otin C. (Cancer Res. 2000) 2 3 4 64
  3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PMID: 11034316) Kojima S. … Seiki M. (FEBS Lett. 2000) 3 4 22 64
  4. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B. … Abel L. (Gut 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for MMP25 Gene

Sources for MMP25 Gene

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