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Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Membrane-Type-6 Matrix Metalloproteinase 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Matrix Metalloproteinase 25 2 3
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MT6-MMP 3 4
  • MMP-25 3 4
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 20 3
  • EC 3.4.24.- 4
  • MT-MMP6 3
  • MMP20A 3

External Ids for MMP25 Gene

Previous HGNC Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Previous GeneCards Identifiers for MMP25 Gene

  • GC16U990147
  • GC16P003130
  • GC16P003097
  • GC16P003100
  • GC16P003102
  • GC16P003037
  • GC16P003038
  • GC16P003106
  • GC16P003108
  • GC16P003068
  • GC16P003109
  • GC16P003111
  • GC16P003127
  • GC16P003151
  • GC16P003139

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP25 Gene

  • May activate progelatinase A

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP25 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

Regulatory Elements for MMP25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP25 Gene

Chromosome:
16
Start:
3,045,963 bp from pter
End:
3,060,729 bp from pter
Size:
14,767 bases
Orientation:
Plus strand

Genomic View for MMP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA2-MMP25_HUMAN
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Q9NPA2
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    Size:
    562 amino acids
    Molecular mass:
    62554 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Proteomics data for MMP25 Gene at MOPED

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP25 (MMP-25/MT6-MMP)

No data available for DME Specific Peptides for MMP25 Gene

Domains & Families for MMP25 Gene

Gene Families for MMP25 Gene

Suggested Antigen Peptide Sequences for MMP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA2

UniProtKB/Swiss-Prot:

MMP25_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function:
May activate progelatinase A

Enzyme Numbers (IUBMB) for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP25: view

Phenotypes for MMP25 Gene

genes like me logo Genes that share phenotypes with MMP25: view

Animal Model Products

miRNA for MMP25 Gene

miRTarBase miRNAs that target MMP25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP25

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP25 Gene COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10628838
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP25: view

Pathways & Interactions for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10706098
GO:0006954 inflammatory response NAS 10628838
GO:0060022 hard palate development IEA --
genes like me logo Genes that share ontologies with MMP25: view

No data available for SIGNOR curated interactions for MMP25 Gene

Drugs & Compounds for MMP25 Gene

(2) Drugs for MMP25 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Calcium Nutra 0

(5) Additional Compounds for MMP25 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
Minocycline hydrochloride
13614-98-7
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

Unigene Clusters for MMP25 Gene

Matrix metallopeptidase 25:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
MMP25
ECgene alternative splicing isoforms for
MMP25

Expression for MMP25 Gene

mRNA expression in normal human tissues for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (x46.5).

SOURCE GeneReport for Unigene cluster for MMP25 Gene Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene

Q9NPA2-MMP25_HUMAN
Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas
genes like me logo Genes that share expression patterns with MMP25: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MMP25 Gene

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP25 35
  • 85.63 (n)
  • 86.02 (a)
MMP25 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP25 35
  • 83.36 (n)
  • 82.29 (a)
MMP25 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp25 35
  • 79.43 (n)
  • 78.53 (a)
Mmp25 16
Mmp25 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP25 35
  • 99.53 (n)
  • 99.11 (a)
MMP25 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP25 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP25 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP25 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp25 35
  • 56.21 (n)
  • 52.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333601 35
  • 52.71 (n)
  • 47.48 (a)
CABZ01030094.1 36
  • 44 (a)
OneToMany
MMP25 (2 of 2) 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 34 (a)
Mmp2 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 35
  • 51.31 (n)
  • 41.87 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for MMP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP25 Gene

ENSEMBL:
Gene Tree for MMP25 (if available)
TreeFam:
Gene Tree for MMP25 (if available)

Paralogs for MMP25 Gene

(11) SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Sequence variations from dbSNP and Humsavar for MMP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs115019427 -- 3,048,773(+) CAGAA(A/G)GGAAG intron-variant, upstream-variant-2KB
rs115453077 -- 3,050,939(+) ATGTG(C/T)ACCAC intron-variant
rs115904634 -- 3,049,503(+) GCTGG(A/G)AAAGG intron-variant
rs116736171 -- 3,050,795(+) TGTTT(G/T)TTTTA intron-variant
rs116957794 -- 3,049,183(+) GAAGA(C/T)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv833125 CNV Loss 17160897
nsv509589 CNV Insertion 20534489
nsv905198 CNV Loss 21882294
esv2750390 CNV Deletion 23290073
dgv360e201 CNV Deletion 23290073
esv2750392 CNV Deletion 23290073
nsv905199 CNV Loss 21882294

Variation tolerance for MMP25 Gene

Residual Variation Intolerance Score: 62.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP25 Gene

HapMap Linkage Disequilibrium report
MMP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP25 Gene

Disorders for MMP25 Gene

Relevant External Links for MMP25

Genetic Association Database (GAD)
MMP25
Human Genome Epidemiology (HuGE) Navigator
MMP25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP25
genes like me logo Genes that share disorders with MMP25: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D.Q. (Cell Res. 1999) 2 23 67
  2. Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers. (PMID: 20432456) Delassus G.S. … Eliceiri G.L. (J. Cell. Physiol. 2010) 23 67
  3. Effects of IL-2 on MMP expression in freshly isolated human NK cells and the IL-2-independent NK cell line YT. (PMID: 20463600) Edsparr K. … Albertsson P. (J. Immunother. 2010) 23 67
  4. Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis. (PMID: 19726693) Shiryaev S.A. … Strongin A.Y. (J. Biol. Chem. 2009) 23 67
  5. Localization of matrix metalloproteinases (MMPs-2, 8, 9 and 20) in normal and carious dentine. (PMID: 20415934) Shimada Y. … Tagami J. (Aust Dent J 2009) 23 67

Products for MMP25 Gene

Sources for MMP25 Gene

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