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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP25 Gene

protein-coding GIFtS: 60
GCID: GC16P003111

matrix metallopeptidase 25

(Previous names: matrix metalloproteinase 25, matrix metallopeptidase-like...)
(Previous symbols: MMPL1, MMP20)

Explore 27 diseases affiliated with
MMP25 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 25¹ ²		MT-MMP 6² ³
MMP20¹ ² ³		MMP20A²
MMPL1¹ ² ³		MT-MMP6²
MT6-MMP¹ ² ³		Leukolysin³
Matrix Metallopeptidase-Like 1¹ ²		Matrix Metalloproteinase 20²
Matrix Metalloproteinase 25¹ ²		Matrix Metalloproteinase-25²
Membrane-Type Matrix Metalloproteinase 6² ³		Matrix Metalloproteinase-Like 1²
Membrane-Type-6 Matrix Metalloproteinase² ³		Membrane-Type 6 Matrix Metalloproteinase²
MMP-25² ³		EC 3.4.24.-³
MT6MMP² ³		Leukolysin³
MTMMP6² ³

External Ids:	HGNC: 14246¹	Entrez Gene: 64386²	Ensembl: ENSG00000008516⁷	OMIM: 608482⁵	UniProtKB: Q9NPA2³

Export aliases for MMP25 gene to outside databases

Previous GC identifers: GC16U990147 GC16P003130 GC16P003097 GC16P003100 GC16P003102 GC16P003037 GC16P003038 GC16P003106 GC16P003108 GC16P003068 GC16P003109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP25:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP

(MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to

bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a

major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the

transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor

invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been

renamed MMP25. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2

Function: May activate progelatinase A

summary for MMP25:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP25

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP25 gene promoter:
STAT3 HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MMP25 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

MMP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP25 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003111: view genomic region (about GC identifiers)

Start:	3,096,682 bp from pter	End:	3,110,727 bp from pter
Size:	14,046 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2 (See protein sequence)

Recommended Name: Matrix metalloproteinase-25 precursor

Size: 562 amino acids; 62554 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Cofactor: Calcium (By similarity)

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space,

extracellular matrix

Secondary accessions: D3DUA8 Q9H3Q0

Explore the universe of human proteins at neXtProt for MMP25: NX_Q9NPA2

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NPA2

MMP25 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071913.1

ENSEMBL proteins:

ENSP00000337816

Reactome Protein details: Q9NPA2
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MMP25

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	NAS	10628838
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	IDA	12493773
GO:0016020	membrane	NAS	11034316
GO:0031225	anchored to membrane	IEA	--

MMP25 for ontologies About GeneDecksing

MMP25 Antibody Products:

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	Novus Biologicals MMP25 Antibody
	Search for Antibodies for MMP25 at Abcam
	Uscn Antibodies for MMP25
	ThermoFisher Antibodies for MMP25

Assay Products for MMP25:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for MMP25
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MMP25

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP25 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR024079 MetalloPept_cat_dom

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018487 Hemopexin/matrixin_repeat

IPR006026 Peptidase_Metallo

Graphical View of Domain Structure for InterPro Entry Q9NPA2

ProtoNet protein and cluster: Q9NPA2

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2

Function: May activate progelatinase A

Enzyme Number (IUBMB): EC 3.4.24.-¹

miRNA Products:		OriGene 3'-UTR Clone: MMP25 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP25
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP25:
		hsa-miR-485-5p hsa-miR-525-5p hsa-miR-491-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MMP25 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP25 (see all 4) OriGene shRNA RFP: MMP25 OriGene siRNA: MMP25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP25

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP25

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP25 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP25 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP25 (NM_022468)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP25

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP25
		Search LifeMap BioReagents cell lines for MMP25

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP25

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP25 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Mmp25 (no phenotypes)

MMP25 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

Degradation of the extracellular matrix

1.00

Activation of Matrix Metalloproteinases

0.40

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

MT-MMPs are sorted to the plasma membrane

MT-MMPs are sorted to the plasma membrane

1.00

Collagen formation

Extracellular matrix organization

0.54

Cell adhesion_ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MMP25

Metalloproteases in connective tissue degradation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MMP25

Inhibition of Matrix Metalloproteinases

1 BioSystems Pathway for MMP25

Matrix Metalloproteinases

4 Reactome Pathways for MMP25

	Extracellular matrix organization
	MT-MMPs are sorted to the plasma membrane
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases

MMP25 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MMP25

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for MMP25 (Q9NPA2³ ENSP00000337816⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP2	P08253³, ENSP00000219070⁴	I2D: score=1 STRING: ENSP00000219070
CLU	P10909³, ENSP00000315130⁴	I2D: score=1 STRING: ENSP00000315130
SVIL	O95425³, ENSP00000348128⁴	I2D: score=1 STRING: ENSP00000348128

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	10706098
GO:0006954	inflammatory response	NAS	10628838
GO:0060022	hard palate development	IEA	--

MMP25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for MMP25:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for MMP25 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP25 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MMP25 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951

Search CenterWatch for drugs/clinical trials and news about MMP25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP25 gene (3 alternative transcripts):

NM_022468.4 NM_004142.1 NM_022718.2

Unigene Cluster for MMP25:

Matrix metallopeptidase 25

Hs.654979 [show with all ESTs]

Unigene Representative Sequence: AJ272137

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336577(uc002cth.3) ENST00000570755(uc002cti.1) ENST00000575441

miRNA Products:		OriGene 3'-UTR Clone: MMP25 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP25
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP25:
		hsa-miR-485-5p hsa-miR-525-5p hsa-miR-491-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: MMP25 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP25 (see all 4) OriGene shRNA RFP: MMP25 OriGene siRNA: MMP25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP25

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP25 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP25 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP25 (NM_022468)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP25

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP25
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP25
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP25

Additional cDNA sequence:

AB042328.1 AF145442.2 AF185270.1 AJ003144.1 AJ239053.1 AJ272137.1 BC111412.1

11 DOTS entries:

DT.120679757 DT.209614 DT.120679722 DT.92424196 DT.75196456 DT.92424189 DT.102827306 DT.120679748

DT.99999733 DT.418757 DT.92424190

24/44 AceView cDNA sequences (see all 44):

AJ003144 CB529891 AJ239053 AF185270 AF145442 NM_022718 NM_022468 W76447

BX281320 AI382081 R44239 AI673133 BV197493 AI951282 H46128 AW205413

AJ272137 AW515724 D20397 W72721 H46127 AI923653 AW294073 NM_004142

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MMP25 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MMP25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP25

SOURCE GeneReport for Unigene cluster: Hs.654979

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2

Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma,

astrocytoma and glioblastomas

SABiosciences Expression via Pathway-Focused PCR Array including MMP25:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP25 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP25

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP25

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP25 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MMP25⁶	--	55(a)	1 ↔ 1	GL343516.1(392301-401890)
zebrafish (Danio rerio)	Actinopterygii	LOC100333601¹	matrix metalloproteinase-25-like	53.47(n) 48.57(a)		100333601 XM_002663896.1 XP_002663942.1
fruit fly (Drosophila melanogaster)	Insecta	Mmp2³	oogenesis metalloendopeptidase	36(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	38(a)		V(2905685-2909407) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT1G59970⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	26(a) 24(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 1(22073534-22074876)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	9(a) 26(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 2(30974996-30977090)

ENSEMBL Gene Tree for MMP25 (if available)
TreeFam Gene Tree for MMP25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP25 gene

MMP13² MMP20² MMP8² MMP14² MMP9² MMP16² MMP2² MMP24²

MMP15² MMP11² MMP3² MMP27² MMP17² MMP10² MMP1²

15 SIMAP similar genes for MMP25 using alignment to 2 protein entries: MMP25_HUMAN (see all proteins):

mmp20 MMP17 MMP16 MMP14 MMP15 MMP7

MMP24 MMP10 MMP11 MMP3 MMP1 MMP13

MMP12 MMP19 MMP8

MMP25 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56269903^1,2		--	3076380(+)	`AGAGGC/TGGGGA`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs74005579^1,2	C,	--	3077011(+)	`CGTCAG/ATGCGG`	2	--	us2k¹ int¹		2		WA	120
rs74005580^1,2	C,F,	--	3077179(+)	`TGCTAC/GCCCTC`	2	--	int¹ us2k¹		3		WA CSA	122
rs55795104^1,2	C,	--	3077276(+)	`CTATGT/AACCTG`	2	--	int¹ us2k¹		1		NA	2
rs56307374^1,2	F,	--	3077556(+)	`GGGCCG/AGCAGG`	2	--	int¹ us2k¹		2		WA NA	238
rs55999592^1,2		--	3077565(+)	`GGCTGG/TGTTCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs55977932^1,2		--	3077628(+)	`GGGGTG/TGGGGT`	2	--	int¹ us2k¹		0	--	--	--	--
rs75407793^1,2	F,	--	3077921(+)	`TCACCC/TCACCG`	2	--	int¹ us2k¹		1		NA	120
rs77598228^1,2	C,	--	3077922(+)	`CACCCC/GACCGC`	2	--	us2k¹ int¹		2		WA	120
rs78549933^1,2		--	3078428(+)	`GACTGA/GAGACA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MMP25 (3096682 - 3110727 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP25: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP25

DNA2.0 Custom Variant and Variant Library Synthesis for MMP25

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP25 for disorders           About GeneDecksing

OMIM gene information: 608482    OMIM disorders: --

20/27 diseases for MMP25 (see all 27):    About MalaCards

weill-marchesani syndrome encephalomyelitis arthritis cleft lip/palate

amelogenesis imperfecta dentinogenesis imperfecta cleft lip dentin dysplasia

cleft palate aggressive periodontitis periodontitis multiple sclerosis

hepatitis c periodontal disease atopy hepatitis b

colon carcinoma gingivitis colon cancer hepatitis

4 diseases from the University of Copenhagen DISEASES database for MMP25:

Amelogenesis imperfecta Dentinogenesis imperfecta Dentin dysplasia Dental fluorosis

2 Novoseek disease relationships for MMP25 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.388	2	20432456 (1), 18936094 (1)
tumors	0	2	14583471 (2)

Human Genome Epidemiology (HuGE) Navigator: MMP25 (9 documents)

Export disorders for MMP25 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP25 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with MMP25)

Utopia: connect your pdf to the dynamic
world of online information

Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PubMed id 10628838)^{1, 2, 3, 9} Pei D.Q. (1999)
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PubMed id 10706098)^{1, 2, 3} Velasco G.... Lopez-Otin C. (2000)
Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PubMed id 11034316)^{1, 2, 9} Kojima S.... Seiki M. (2000)
Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond. (PubMed id 14583471)^{1, 9} Nie J. and Pei D. (2003)
Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25). (PubMed id 11226436)^{1, 9} English W.R....Murphy G. (2001)
Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. (PubMed id 15149845)^{1, 9} Nie J. and Pei D. (2004)
Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils. (PubMed id 11282999)^{1, 9} Kang T....Pei D. (2001)
Identification and Role of the Homodimerization Interface of the Glycosylphosphatidylinositol-anchored Membrane Type 6 Matrix Metalloproteinase (MMP25). (PubMed id 18936094)^{1, 9} Zhao H....Fridman R. (2008)
Inflammatory proprotein convertase-matrix metalloprot einase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis. (PubMed id 19726693)^{1, 9} Shiryaev S.A....Strongin A.Y. (2009)
Biochemical characterization and N-terminomics analysi s of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine a nd vimentin cleavages enhance cell migration and macrophage phagocytic activitie s. (PubMed id 22367194)¹ Starr A.E....Overall C.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64386	HGNC: 14246	AceView: MMPL1	Ensembl:ENSG00000008516	euGenes: HUgn64386
ECgene: MMP25	H-InvDB: MMP25

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP25	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP25	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MMP25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MMP25 gene:
Search GeneIP for patents involving MMP25

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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MMP25 Gene

matrix metallopeptidase 25

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MMP25 (Gene Symbol)
Matrix Metallopeptidase 25
MMP20
MMPL1
MT6-MMP
Matrix Metallopeptidase-Like 1
Matrix Metalloproteinase 25
Membrane-Type Matrix Metalloproteinase 6
Membrane-Type-6 Matrix Metalloproteinase
MMP-25
MT6MMP
MTMMP6
MT-MMP 6
MMP20A
MT-MMP6
Leukolysin
Matrix Metalloproteinase 20
Matrix Metalloproteinase-25
Matrix Metalloproteinase-Like 1
Membrane-Type 6 Matrix Metalloproteinase
EC 3.4.24.-
Leukolysin

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MMP25 Gene

matrix metallopeptidase 25

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