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MMP25 Gene

protein-coding   GIFtS: 61
GCID: GC16P003151

Matrix Metallopeptidase 25

(Previous names: matrix metalloproteinase 25, matrix metallopeptidase-like...)
(Previous symbols: MMPL1, MMP20)
  See MMP25-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 251 2     MT-MMP 62 3
MMP201 2 3     MMP20A2 5
MMPL11 2 3     MT-MMP62
Matrix Metallopeptidase-Like 11 2     leukolysin2
Matrix Metalloproteinase 251 2     Matrix Metalloproteinase 202
Membrane-Type Matrix Metalloproteinase 62 3     Matrix Metalloproteinase-252
Membrane-Type-6 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-Like 12
MMP-252 3     Membrane-Type 6 Matrix Metalloproteinase2
MT6-MMP2 3     EC 3.4.24.-3
MT6MMP2 3     Leukolysin3
MTMMP62 3     

External Ids:    HGNC: 142461   Entrez Gene: 643862   Ensembl: ENSG000000085167   OMIM: 6084825   UniProtKB: Q9NPA23   

Export aliases for MMP25 gene to outside databases

Previous GC identifers: GC16U990147 GC16P003130 GC16P003097 GC16P003100 GC16P003102 GC16P003037 GC16P003038 GC16P003106 GC16P003108 GC16P003068 GC16P003109 GC16P003111 GC16P003127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP25 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the
membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor.
In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1
proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils,
facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also
play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to
as MMP20 but has been renamed MMP25. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP25 Gene:
MMP25 (matrix metallopeptidase 25) is a protein-coding gene. Diseases associated with MMP25 include dental fluorosis, and encephalomyelitis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2
Function: May activate progelatinase A

summary for MMP25 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP25 gene promoter:
         STAT3   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MMP25 promoter sequence
   Search Chromatin IP Primers for MMP25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MMP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP25 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003151:  view genomic region     (about GC identifiers)

Start:
3,096,682 bp from pter      End:
3,110,727 bp from pter
Size:
14,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2 (See protein sequence)
Recommended Name: Matrix metalloproteinase-25 precursor  
Size: 562 amino acids; 62554 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Secondary accessions: D3DUA8 Q9H3Q0

Explore the universe of human proteins at neXtProt for MMP25: NX_Q9NPA2

Explore proteomics data for MMP25 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Modification sites at neXtProt

  • See MMP25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071913.1  
    ENSEMBL proteins: 
     ENSP00000337816  
    Reactome Protein details: Q9NPA2

    MMP25 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MMP25

     
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    antibodies-online proteins for MMP25 

     
    antibodies-online peptides for MMP25

    MMP25 Antibody Products:

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    antibodies-online antibodies for MMP25 (29 products) 

    MMP25 Assay Products:

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    Cloud-Clone Corp. ELISAs for MMP25
    Cloud-Clone Corp. CLIAs for MMP25
    Search eBioscience for ELISAs for MMP25 
    antibodies-online kits for MMP25 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP25
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 9):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat
     IPR006026 Peptidase_Metallo

    Graphical View of Domain Structure for InterPro Entry Q9NPA2

    ProtoNet protein and cluster: Q9NPA2

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP25_HUMAN, Q9NPA2
    Function: May activate progelatinase A

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP25           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Mmp25 (no phenotypes)

    Find genes that share phenotypes with MMP25           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MMP25

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP25:
    hsa-mir-181c-3p (MIRT038668), hsa-mir-16-5p (MIRT051134)

    Block miRNA regulation of human, mouse, rat MMP25 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MMP25:
    hsa-miR-485-5p hsa-miR-525-5p hsa-miR-491-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMMP25 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MMP25
    Predesigned siRNA for gene silencing in human, mouse, rat MMP25

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MMP25 (see all 7)
    OriGene ORF clones in mouse, rat for MMP25
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    GenScript: all cDNA clones in your preferred vector: MMP25 (NM_022468)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP25

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP25 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP25_HUMAN, Q9NPA2: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space,
    extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10628838
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS11034316
    GO:0031012extracellular matrix ----
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with MMP25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP25 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31


    Find genes that share SuperPaths with MMP25           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MMP25
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for MMP25
        Matrix Metalloproteinases

    1 Reactome Pathway for MMP25
        Activation of Matrix Metalloproteinases


        Pathway & Disease-focused RT2 Profiler PCR Array including MMP25: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MMP25

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MMP25 (Q9NPA23 ENSP000003378164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    CLUP109093, ENSP000003151304I2D: score=1 STRING: ENSP00000315130
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    DLL1ENSP000003557184STRING: ENSP00000355718
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10706098
    GO:0006954inflammatory response NAS10628838
    GO:0060022hard palate development IEA--

    Find genes that share ontologies with MMP25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP25 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP25    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP25    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP25 gene (3 alternative transcripts): 
    NM_022468.4  NM_004142.1  NM_022718.2  

    Unigene Cluster for MMP25:

    Matrix metallopeptidase 25
    Hs.654979  [show with all ESTs]
    Unigene Representative Sequence: AJ272137
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336577(uc002cth.3) ENST00000570755(uc002cti.1) ENST00000575441

    miRNA
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    Block miRNA regulation of human, mouse, rat MMP25 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MMP25:
    hsa-miR-485-5p hsa-miR-525-5p hsa-miR-491-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMMP25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MMP25
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    GenScript: all cDNA clones in your preferred vector: MMP25 (NM_022468)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MMP25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP25
      QuantiTect SYBR Green Assays in human, mouse, rat MMP25
      QuantiFast Probe-based Assays in human, mouse, rat MMP25

    Additional mRNA sequence: 

    AB042328.1 AF145442.2 AF185270.1 AJ003144.1 AJ239053.1 AJ272137.1 BC111412.1 

    11 DOTS entries:

    DT.120679757  DT.209614  DT.120679722  DT.92424196  DT.75196456  DT.92424189  DT.102827306  DT.120679748 
    DT.99999733  DT.418757  DT.92424190 

    Selected AceView cDNA sequences (see all 44):

    NM_022468 BX281320 CB529891 W76447 NM_022718 AI382081 AF145442 AF185270 
    AJ003144 AJ239053 BV197493 H49692 H46127 AW294073 AI673133 AW205413 
    NM_004142 R44239 AJ272137 H46128 AI083895 AI220935 D20397 AI951282 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MMP25 Expression
    About this image


    MMP25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
    MMP25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654979

    UniProtKB/Swiss-Prot: MMP25_HUMAN, Q9NPA2
    Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma,
    astrocytoma and glioblastomas

        Pathway & Disease-focused RT2 Profiler PCR Array including MMP25: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP25 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp251 , 5 matrix metallopeptidase 251, 5 79.43(n)1
    78.53(a)1
      17 (11.87 cM)5
    2400471  NM_001033339.31  NP_001028511.11 
     236294585 
    lizard
    (Anolis carolinensis)
    Reptilia MMP256
    matrix metallopeptidase 25
    52(a)
    1 ↔ 1
    GL343516.1(392295-414902)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp251 matrix metallopeptidase 25 56.21(n)
    52.43(a)
      100379875  XM_002943047.2  XP_002943093.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003336011 matrix metalloproteinase-25-like 52.71(n)
    47.48(a)
      100333601  XM_002663896.2  XP_002663942.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0039291 AgaP_AGAP003929 51.31(n)
    41.87(a)
      3290935  XM_554330.4  XP_554330.4 


    ENSEMBL Gene Tree for MMP25 (if available)
    TreeFam Gene Tree for MMP25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP25 gene
    MMP202  MMP132  MMP82  MMP142  MMP162  MMP72  MMP242  MMP152  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    11 SIMAP similar genes for MMP25 using alignment to 2 protein entries:     MMP25_HUMAN (see all proteins):
    mmp20    MMP17    MMP16    MMP14    MMP15    MMP7
    MMP24    MMP10    MMP11    MMP3    MMP1

    Find genes that share paralogs with MMP25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP25 (see all 283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501221881,2
    --3094734(+) GTTGTC/TCCAGC 1 -- us2k10--------
    rs1384366681,2
    --3094792(+) GGCTGC/TGGTGA 1 -- us2k10--------
    rs1860788541,2
    --3094866(+) AACAAA/GCAAAC 1 -- us2k10--------
    rs1130318471,2
    C,F--3094893(+) ACCAAC/ACAAAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1437630831,2
    --3095018(+) AATGAA/GGCTTT 1 -- us2k10--------
    rs1887154561,2
    --3095100(+) CAGAAC/TTTTGG 1 -- us2k10--------
    rs1812393241,2
    --3095117(+) GAGGCC/GGGCAG 1 -- us2k10--------
    rs1853448421,2
    --3095238(+) TACTCC/GGGAGG 1 -- us2k10--------
    rs1481270361,2
    --3095369(+) AAAACA/CAAACA 1 -- us2k10--------
    rs607333611,2
    C,F--3095380(+) AAACAA/GAAGAG 1 -- us2k13Minor allele frequency- G:0.06WA CSA 122

    HapMap Linkage Disequilibrium report for MMP25 (3096682 - 3110727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MMP25 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv360e201CNV Deletion23290073
    esv2750392CNV Deletion23290073
    esv2750390CNV Deletion23290073
    nsv509589CNV Insertion20534489
    nsv905199CNV Loss21882294
    dgv2579n71CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    dgv2575n71CNV Loss21882294
    nsv905198CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP25
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608482    OMIM disorders: --

    3 diseases for MMP25:    
    About MalaCards
    dental fluorosis    encephalomyelitis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for MMP25:
    Amelogenesis imperfecta     Dental fluorosis

    Find genes that share disorders with MMP25           About GenesLikeMe

    2 Novoseek inferred disease relationships for MMP25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.388 2 20432456 (1), 18936094 (1)
    tumors 0 2 14583471 (2)

    Genetic Association Database (GAD): MMP25
    Human Genome Epidemiology (HuGE) Navigator: MMP25 (9 documents)

    Export disorders for MMP25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP25 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with MMP25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PubMed id 10628838)1, 2, 3, 9 Pei D.Q. (Cell Res. 1999)
    2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PubMed id 10706098)1, 2, 3 Velasco G.... Lopez-Otin C. (Cancer Res. 2000)
    3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PubMed id 11034316)1, 2, 9 Kojima S.... Seiki M. (FEBS Lett. 2000)
    4. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    8. Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond. (PubMed id 14583471)1, 9 Nie J. and Pei D. (Cancer Res. 2003)
    9. Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25). (PubMed id 11226436)1, 9 English W.R....Murphy G. (FEBS Lett. 2001)
    10. Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. (PubMed id 15149845)1, 9 Nie J. and Pei D. (Exp. Cell Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64386 HGNC: 14246 AceView: MMPL1 Ensembl:ENSG00000008516 euGenes: HUgn64386
    ECgene: MMP25 H-InvDB: MMP25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP25 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP25 gene:
    Search GeneIP for patents involving MMP25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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