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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP24 Gene

protein-coding   GIFtS: 67
GCID: GC20P033814

matrix metallopeptidase 24 (membrane-inserted)

(Previous name: matrix metalloproteinase 24 (membrane-inserted) )
 Explore 18 diseases affiliated with
MMP24 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MMP24    

Aliases
for MMP24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Metallopeptidase 24 (Membrane-Inserted)1 2     MT-MMP 52 3
MT5-MMP1 2 3     MMP252 5
Matrix Metalloproteinase 24 (Membrane-Inserted)1 2     MT-MMP52
Membrane-Type Matrix Metalloproteinase 52 3     Matrix Metalloproteinase-242
Membrane-Type-5 Matrix Metalloproteinase2 3     Membrane-Type 5 Matrix Metalloproteinase2
MMP-242 3     EC 3.4.24.-3
MT5MMP2 3     EC 3.4.248
MTMMP52 3     EC 3.4.24.808

External Ids:    HGNC: 71721   Entrez Gene: 108932   Ensembl: ENSG000001259667   OMIM: 6048715   UniProtKB: Q9Y5R23   

Export aliases for MMP24 gene to outside databases

Previous GC identifers: GC20P033573 GC20P034483 GC20P034530 GC20P033278 GC20P030592


Summaries
for MMP24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MMP24:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP
(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these
proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has
previously been referred to as MMP25 but has been renamed MMP24. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
Function: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as
dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor
laminin (By similarity)

summary for MMP24:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP24


Genomic Views
for MMP24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP24 gene promoter:
         AREB6   Sp1   AML1a   Pax-5   NRSF form 1   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP24 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.2

MMP24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033814:  view genomic region     (about GC identifiers)

Start:
 33,814,457 bp from pter      End:
 33,864,804 bp from pter
Size:
 50,348 bases      Orientation:
 plus strand

Proteins
for MMP24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2 (See protein sequence)
Recommended Name: Matrix metalloproteinase-24 precursor  
Size: 645 amino acids; 73231 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity)
Subcellular location: Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix (By
similarity). Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage (By similarity)
Secondary accessions: B7ZBG8 Q9H440

Explore the universe of human proteins at neXtProt for MMP24: NX_Q9Y5R2

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5R2

    • 4/13 DME Specific Peptides for MMP24 (Q9Y5R2) (see all 13)
     LRDWMGC  FVFFKGD  PRCGVPD  AIMAPFYQ 

    MMP24 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006681.1  
    ENSEMBL proteins: 
     ENSP00000246186  
    Reactome Protein details: Q9Y5R2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP24 (MMP-24/MT5-MMP)
    Enzo Life Sciences proteins for MMP24
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MMP24 
    GenScript Custom Purified and Recombinant Proteins Services for MMP24
    Novus Biologicals MMP24 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MMP24

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005887integral to plasma membrane TAS10363975


    MMP24 for ontologies           About GeneDecksing



    MMP24 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP24
    R&D Systems Antibodies for MMP24 (MMP-24/MT5-MMP)
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    OriGene Custom Antibody Services for MMP24 
    GenScript Custom Superior Antibodies Services for MMP24
    Novus Biologicals MMP24 Antibodies
    Abcam antibodies for MMP24 
    Uscn Antibodies for MMP24
    ThermoFisher Antibodies for MMP24

    Assay Products for MMP24: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMP24
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MMP24

    Protein Domains /
    Families
    for MMP24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MMP24 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A_matrixin
     IPR000585 Hemopexin/matrixin
     IPR018486 Hemopexin/matrixin_CS
     IPR018487 Hemopexin/matrixin_repeat

    Graphical View of Domain Structure for InterPro Entry Q9Y5R2

    ProtoNet protein and cluster: Q9Y5R2

    3 Blocks protein families:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin-like domains


    Function
    for MMP24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
    Function: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as
    dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor
    laminin (By similarity)

         Genatlas biochemistry entry for MMP24:
    matrix metalloproteinase 24,membrane type (MT),expressed in brain,kidney,pancreas and lung activator of
    progelalinase,overexpressed in brain tumor,involved in neurogenesis

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

    miRNA
    Products:            		miRTarBase miRNAs that target MMP24:
    hsa-mir-29b (MIRT005385), hsa-mir-29c (MIRT005386)

    OriGene 3'-UTR Clone: MMP24
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP24
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP24 (see all 96):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: MMP24 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP24 (see all 7)
    OriGene shRNA RFP: MMP24
    OriGene siRNA: MMP24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP24

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MMP24

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP24 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP24
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MMP24 (NM_006690)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP24 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MMP24
    Search LifeMap BioReagents cell lines for MMP24

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP24

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS10363975
    GO:0008270zinc ion binding IEA--


    MMP24 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MMP24:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased number of cells in m 

    Animal Models:
         Mouse knock-outs for MMP24: Mmp24tm1Ski Mmp24tm1Otin
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp24):
     behavior/neurological  cellular  immune system  integument  nervous system 

    MMP24 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MMP24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Activation of Matrix Metalloproteinases0.40
    2Matrix Metalloproteinases
    		Matrix Metalloproteinases1.00
    		Inhibition of Matrix Metalloproteinases0.68
    3MT-MMPs are sorted to the plasma membrane
    		MT-MMPs are sorted to the plasma membrane1.00
    4Collagen formation
    		Extracellular matrix organization0.54
    5Cell adhesion_ECM remodeling
    		Metalloproteases in connective tissue degradation0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MMP24
        Metalloproteases in connective tissue degradation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MMP24
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for MMP24 
        Matrix Metalloproteinases

    4        Reactome Pathways for MMP24
        Extracellular matrix organization
    MT-MMPs are sorted to the plasma membrane
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases



    MMP24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MMP24 (Q9Y5R22, 3 ENSP000002461864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1Q157263, ENSP000003561624I2D: score=1 STRING: ENSP00000356162
    --Q9R0642MINT-7897866
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0043085positive regulation of catalytic activity TAS10363975


    MMP24 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MMP24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for MMP24:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP24 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
    PD 166793Broad spectrum MMP inhibitor[199850-67-4]

    2 HMDB Compounds for MMP24    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 DrugBank Compound for MMP24    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    Search CenterWatch for drugs/clinical trials and news about MMP24 

    Transcripts
    for MMP24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MMP24 gene: 
    NM_006690.3  

    Unigene Cluster for MMP24:

    Matrix metallopeptidase 24 (membrane-inserted)
    Hs.715494  [show with all ESTs]
    Unigene Representative Sequence: NM_006690
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246186(uc002xbu.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MMP24
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP24
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP24 (see all 96):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: MMP24 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP24 (see all 7)
    OriGene shRNA RFP: MMP24
    OriGene siRNA: MMP24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP24
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP24 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP24
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MMP24 (NM_006690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP24 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP24
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP24
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP24
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP24

    Additional cDNA sequence: 

    AB021227.1 AF131284.1 AK096805.1 BC047614.1 DQ300264.1 

    11 DOTS entries:

    DT.447267  DT.100820856  DT.95280269  DT.92408290  DT.120830555  DT.92455922  DT.99933111  DT.95074569 
    DT.101976058  DT.91969069  DT.95078223 

    24/180 AceView cDNA sequences (see all 180):

    BF915905 AI498629 BM129062 AI348656 BF058971 BQ931492 AI423812 AW043820 
    AI299745 AI741492 AI097473 BF915906 F01927 BE301849 F04682 AI805058 
    AA372274 BF058119 T07980 F09789 BQ430271 BX281430 AI269740 AI656572 

    GeneLoc Exon Structure


    Expression
    for MMP24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACTCGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MMP24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP24

    SOURCE GeneReport for Unigene cluster: Hs.715494

    UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
    Tissue specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain
    tumors, including astrocytomas and glioblastomas

        SABiosciences Custom PCR Arrays for MMP24
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP24
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP24
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP24
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP24

    Orthologs
    for MMP24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP24 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MMP241 matrix metallopeptidase 24 (membrane-inserted) 78.54(n)
    89.95(a)    		   419141  XM_417326.3  XP_417326.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MMP246
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(133950951-133978852)
    zebrafish
    (Danio rerio)    		 Actinopterygii mmp241 matrix metallopeptidase 24 76.24(n)
    83.69(a)    		   571143  XM_694711.3  XP_699803.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea C31B8.83   -- 41(a)
    (best of 2)    		   V(2905685-2909407)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G166406
    AT1G599706
    (see all 5)    		 matrix metalloprotease domain-containing protein
    (see all 5)    		 25(a)
    24(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 4(9367248-9368775)
    1(22073534-22074876)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 metalloendoproteinase 1 precursor, putative, expre...
    metalloendoproteinase 1 precursor, putative, expre...
    (see all 4)    		 24(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 2(30974996-30977090)
    6(7223943-7225418)


    ENSEMBL Gene Tree for MMP24 (if available)
    TreeFam Gene Tree for MMP24 (if available) 

    Paralogs
    for MMP24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP24 gene
    MMP132  MMP202  MMP82  MMP142  MMP92  MMP162  MMP22  MMP252  
    MMP152  MMP112  MMP32  MMP272  MMP172  MMP102  MMP12  
    18 SIMAP similar genes for MMP24 using alignment to 3 protein entries:     MMP24_HUMAN (see all proteins):
    MMP16    MMP14    MMP15    mmp20    MMP17    MMP11
    MMP7    MMP8    MMP20    MMP25    MMP3    MMP13
    MMP12    MMP26    MMP10    MMP1    MMP19    MMP27

    MMP24 for paralogs           About GeneDecksing



    Genomic Variants
    for MMP24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/871 NCBI SNPs in MMP24 are shown (see all 871)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs107108751,2
    		C--30602201(+) AAAAA-/ATCACT 1 -- int1 trp32Minor allele frequency- A:0.25NA 4
    rs1814740281,2
    		--33812594(+) AAACCA/GAGCTC 1 -- us2k10--------
    rs1403472071,2
    		--33812601(+) GCTCCA/TTGTCA 1 -- us2k10--------
    rs1455272521,2
    		--33812646(+) CGTTTC/TTGTGA 1 -- us2k10--------
    rs1864929991,2
    		--33812674(+) TTTCTC/GGATTT 1 -- us2k10--------
    rs1161127061,2
    		F,--33812920(+) ATATCG/ATGGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1420709921,2
    		C,--33812937(+) GCTTA-/GCCCAG 1 -- us2k10--------
    rs60876881,2
    		C--33812992(+) TTATCC/TTTATT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs119070071,2
    		C,F,H,--33813029(+) TCTCCT/CAACCA 1 -- us2k12Minor allele frequency- C:0.20NA WA 122
    rs60876911,2
    		C,H--33813113(+) AGCACC/TTCATG 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 422

    HapMap Linkage Disequilibrium report for MMP24 (33814457 - 33864804 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MMP24: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP24
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP24

    Disorders / Diseases
    for MMP24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MMP24 for disorders           About GeneDecksing

    OMIM gene information: 604871    OMIM disorders: --

    18 diseases for MMP24:    About MalaCards
    encephalomyelitis    arthritis    spontaneous abortion    idiopathic pulmonary fibrosis
    pulmonary fibrosis    cutaneous t cell lymphoma    multiple sclerosis    hepatitis c
    adhd    fibrosis    endometriosis    ovarian cancer
    astrocytoma    breast cancer    glioblastoma    hepatitis
    prostatitis    liver fibrosis

    1 Novoseek disease relationship for MMP24 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10363975 (2)

    Human Genome Epidemiology (HuGE) Navigator: MMP24 (6 documents)

    Export disorders for MMP24 gene to outside databases

    Publications
    for MMP24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP24 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with MMP24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase a overexpressed in brain tumors. (PubMed id 10363975)1, 2, 3, 9 Llano E....Lopez-Otin C. (1999)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    3. Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. (PubMed id 17952761)1, 9 Gaetje R....Kaufmann M. (2007)
    4. Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells. (PubMed id 18062926)1, 9 Ross H.H. and Fillmore H.L. (2007)
    5. Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. (PubMed id 11457723)1, 9 Romanic A.M....Ohlstein E.H. (2001)
    6. Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->q12, respectively, by radiation hybrid and in situ hybridization. (PubMed id 10640822)1, 9 Kinoh H....Seiki M. (1999)
    7. Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. (PubMed id 12879005)1, 9 Takino T.... Sato H. (2003)
    8. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
    9. Interferon gamma receptor 2 gene variants are associa ted with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1 Nalpas B....Abel L. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    External Searches for MMP24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MMP24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10893 HGNC: 7172 AceView: MMP24 Ensembl:ENSG00000125966 euGenes: HUgn10893
    ECgene: MMP24 H-InvDB: MMP24

    Other Databases showing MMP24 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MMP24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP24 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MMP24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MMP24 gene:
    Search GeneIP for patents involving MMP24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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