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MMP24 Gene

protein-coding   GIFtS: 65
GCID: GC20P033814

Matrix Metallopeptidase 24 (Membrane-Inserted)

(Previous name: matrix metalloproteinase 24 (membrane-inserted))
  See MMP24-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 24 (Membrane-Inserted)1 2     MTMMP52 3
Matrix Metalloproteinase 24 (Membrane-Inserted)1 2     MT-MMP 52 3
Membrane-Type 5 Matrix Metalloproteinase1 2     MMP252 5
Membrane-Type Matrix Metalloproteinase 52 3     MT-MMP52
Membrane-Type-5 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-242
MMP-242 3     EC 3.4.24.-3
MT5-MMP2 3     EC 3.4.248
MT5MMP2 3     EC 3.4.24.808

External Ids:    HGNC: 71721   Entrez Gene: 108932   Ensembl: ENSG000001259667   OMIM: 6048715   UniProtKB: Q9Y5R23   

Export aliases for MMP24 gene to outside databases

Previous GC identifers: GC20P033573 GC20P034483 GC20P034530 GC20P033278 GC20P030592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP24 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the
membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain
suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates
MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MMP24 Gene:
MMP24 (matrix metallopeptidase 24 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP24 include arthritis, and idiopathic pulmonary fibrosis. GO annotations related to this gene include enzyme activator activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
Function: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such
as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type
I, nor laminin (By similarity)

summary for MMP24 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MMP24 gene promoter:
         AREB6   Sp1   AML1a   Pax-5   NRSF form 1   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP24 promoter sequence
   Search Chromatin IP Primers for MMP24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.2

MMP24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033814:  view genomic region     (about GC identifiers)

Start:
33,814,457 bp from pter      End:
33,864,804 bp from pter
Size:
50,348 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2 (See protein sequence)
Recommended Name: Matrix metalloproteinase-24 precursor  
Size: 645 amino acids; 73231 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Secondary accessions: B7ZBG8 Q9H440

Explore the universe of human proteins at neXtProt for MMP24: NX_Q9Y5R2

Explore proteomics data for MMP24 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP24 (Q9Y5R2) (see all 13)
     LRDWMGC  FVFFKGD  PRCGVPD  AIMAPFYQ 


    See MMP24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006681.1  
    ENSEMBL proteins: 
     ENSP00000246186  
    Reactome Protein details: Q9Y5R2

    MMP24 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MMP24
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    Novus Biologicals MMP24 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP24

     
    Search eBioscience for Proteins for MMP24 

     
    antibodies-online proteins for MMP24 (5 products) 

     
    antibodies-online peptides for MMP24

    MMP24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MMP24
    Cloud-Clone Corp. Antibodies for MMP24
    ThermoFisher Antibodies for MMP24
    LSBio Antibodies in human, mouse, rat for MMP24
    antibodies-online antibodies for MMP24 (41 products) 

    MMP24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMP24
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    Cloud-Clone Corp. ELISAs for MMP24
    Cloud-Clone Corp. CLIAs for MMP24
    Search eBioscience for ELISAs for MMP24 
    antibodies-online kits for MMP24 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP24
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS
     IPR018487 Hemopexin-like_repeat

    Graphical View of Domain Structure for InterPro Entry Q9Y5R2

    ProtoNet protein and cluster: Q9Y5R2

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP24_HUMAN, Q9Y5R2
    Function: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such
    as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type
    I, nor laminin (By similarity)

         Genatlas biochemistry entry for MMP24:
    matrix metalloproteinase 24,membrane type (MT),expressed in brain,kidney,pancreas and lung activator of
    progelalinase,overexpressed in brain tumor,involved in neurogenesis

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS10363975
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP24           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MMP24:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased number of cells in m 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp24):
     behavior/neurological  cellular  hematopoietic system  immune system  integument 
     nervous system 

    Find genes that share phenotypes with MMP24           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MMP24: Mmp24tm1Ski Mmp24tm1Otin

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP24
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP24
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP24

    miRNA
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    miRTarBase miRNAs that target MMP24:
    hsa-mir-29b-3p (MIRT005385), hsa-mir-29c-3p (MIRT005386)

    Block miRNA regulation of human, mouse, rat MMP24 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP24 (see all 96):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMMP24 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP24
    Predesigned siRNA for gene silencing in human, mouse, rat MMP24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP24

    Clone
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    OriGene clones in human, mouse for MMP24 (see all 6)
    OriGene ORF clones in mouse, rat for MMP24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP24 (NM_006690)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP24

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MMP24
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP24_HUMAN, Q9Y5R2: Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity)
    MMP24_HUMAN, Q9Y5R2: Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix
    (By similarity). Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005887integral component of plasma membrane TAS10363975
    GO:0031012extracellular matrix ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MMP24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP24 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31


    Find genes that share SuperPaths with MMP24           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MMP24
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for MMP24
        Matrix Metalloproteinases

    1 Reactome Pathway for MMP24
        Activation of Matrix Metalloproteinases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP24
    Interactions:

        GeneGlobe Interaction Network for MMP24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MMP24 (Q9Y5R22, 3 ENSP000002461864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1Q157263, ENSP000003561624I2D: score=1 STRING: ENSP00000356162
    --Q9R0642MINT-7897866
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10363975
    GO:0043085positive regulation of catalytic activity TAS10363975

    Find genes that share ontologies with MMP24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP24 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    2 HMDB Compounds for MMP24    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 DrugBank Compound for MMP24    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP24 gene: 
    NM_006690.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246186(uc002xbu.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat MMP24 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP24 (see all 96):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-3138 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidMMP24 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP24
      QuantiTect SYBR Green Assays in human, mouse, rat MMP24
      QuantiFast Probe-based Assays in human, mouse, rat MMP24

    Selected AceView cDNA sequences (see all 180):

    BM806270 AI269740 CD623090 AI348656 BU500894 Z43256 AI804955 AI887909 
    BF732192 F04561 AI097473 AI805058 BF915906 AI262960 AA372274 AW043820 
    BX374642 AI498629 BE048308 BX281430 F04682 BF197543 BE301849 BM129062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGTGT
    MMP24 Expression
    About this image


    MMP24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
    MMP24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP24 Protein Expression

    UniProtKB/Swiss-Prot: MMP24_HUMAN, Q9Y5R2
    Tissue specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of
    brain tumors, including astrocytomas and glioblastomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP24 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp241 , 5 matrix metallopeptidase 241, 5 91.36(n)1
    97.72(a)1
      2 (77.26 cM)5
    173911  NM_010808.31  NP_034938.31 
     1557753425 
    chicken
    (Gallus gallus)
    Aves MMP241 matrix metallopeptidase 24 (membrane-inserted) 78.74(n)
    89.93(a)
      419141  XM_417326.4  XP_417326.4 
    lizard
    (Anolis carolinensis)
    Reptilia MMP246
    matrix metallopeptidase 24 (membrane-inserted)
    87(a)
    1 ↔ 1
    4(133934399-133978852)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp241 matrix metallopeptidase 24 (membrane-inserted) 74.85(n)
    87.72(a)
      100492405  XM_002942279.2  XP_002942325.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp241 matrix metallopeptidase 24 75.96(n)
    82.98(a)
      571143  XM_694711.4  XP_699803.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp13 tracheal system development (sensu
    Insecta) metalloendopeptidase
    37(a)     --


    ENSEMBL Gene Tree for MMP24 (if available)
    TreeFam Gene Tree for MMP24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP24 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP152  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    18 SIMAP similar genes for MMP24 using alignment to 3 protein entries:     MMP24_HUMAN (see all proteins):
    MMP16    MMP14    MMP15    mmp20    MMP17    MMP11
    MMP7    MMP8    MMP20    MMP25    MMP3    MMP13
    MMP12    MMP26    MMP10    MMP1    MMP19    MMP27

    Find genes that share paralogs with MMP24           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP24 (see all 1051)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814740281,2
    --33812594(+) AAACCA/GAGCTC 1 -- us2k10--------
    rs1403472071,2
    C--33812601(+) GCTCCA/TTGTCA 1 -- us2k10--------
    rs1455272521,2
    --33812646(+) CGTTTC/TTGTGA 1 -- us2k10--------
    rs1864929991,2
    --33812674(+) TTTCTC/GGATTT 1 -- us2k10--------
    rs1161127061,2
    F--33812920(+) ATATCG/ATGGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1420709921,2
    C--33812937(+) GCTTA-/GCCCAG 1 -- us2k10--------
    rs60876881,2
    C--33812992(+) TTATCC/TTTATT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs119070071,2
    C,F,H--33813029(+) TCTCCT/CAACCA 1 -- us2k12Minor allele frequency- C:0.20NA WA 122
    rs60876911,2
    C,H--33813113(+) AGCACC/TTCATG 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 422
    rs1133739331,2
    C,F--33813169(+) TGGAAC/TAGAGC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for MMP24 (33814457 - 33864804 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP24: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP24
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604871    OMIM disorders: --

    2 diseases for MMP24:    
    About MalaCards
    arthritis    idiopathic pulmonary fibrosis


    Find genes that share disorders with MMP24           About GenesLikeMe

    1 Novoseek inferred disease relationship for MMP24 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10363975 (2)

    Genetic Association Database (GAD): MMP24
    Human Genome Epidemiology (HuGE) Navigator: MMP24 (6 documents)

    Export disorders for MMP24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP24 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with MMP24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase a overexpressed in brain tumors. (PubMed id 10363975)1, 2, 3, 9 Llano E....Lopez-Otin C. (Cancer Res. 1999)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. (PubMed id 17952761)1, 9 Gaetje R....Kaufmann M. (Gynecol. Endocrinol. 2007)
    9. Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells. (PubMed id 18062926)1, 9 Ross H.H. and Fillmore H.L. (FEBS Lett. 2007)
    10. Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. (PubMed id 11457723)1, 9 Romanic A.M....Ohlstein E.H. (Am. J. Physiol. Renal Physiol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10893 HGNC: 7172 AceView: MMP24 Ensembl:ENSG00000125966 euGenes: HUgn10893
    ECgene: MMP24 H-InvDB: MMP24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP24 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP24 gene:
    Search GeneIP for patents involving MMP24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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