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Aliases for MMP24 Gene

Aliases for MMP24 Gene

  • Matrix Metallopeptidase 24 2 3 5
  • Matrix Metalloproteinase 24 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 24 (Membrane-Inserted) 2 3
  • Membrane-Type 5 Matrix Metalloproteinase 2 3
  • Membrane-Type Matrix Metalloproteinase 5 3 4
  • MT-MMP 5 3 4
  • MT5-MMP 3 4
  • MMP-24 3 4
  • MT5MMP 3 4
  • MTMMP5 3 4
  • Membrane-Type-5 Matrix Metalloproteinase 4
  • Matrix Metalloproteinase-24 3
  • EC 3.4.24.80 61
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • MT-MMP5 3
  • MMP25 3

External Ids for MMP24 Gene

Previous GeneCards Identifiers for MMP24 Gene

  • GC20P033573
  • GC20P034483
  • GC20P034530
  • GC20P033278
  • GC20P033814
  • GC20P030592

Summaries for MMP24 Gene

Entrez Gene Summary for MMP24 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). [provided by RefSeq, Feb 2016]

GeneCards Summary for MMP24 Gene

MMP24 (Matrix Metallopeptidase 24) is a Protein Coding gene. Among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP16.

UniProtKB/Swiss-Prot for MMP24 Gene

  • Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Tocris Summary for MMP24 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP24 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP24 Gene

Genomics for MMP24 Gene

Regulatory Elements for MMP24 Gene

Enhancers for MMP24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035250 1.2 FANTOM5 Ensembl ENCODE 20.8 +25.2 25217 3.7 CTCF ESRRA PKNOX1 TAL1 ZNF2 ZIC2 RAD21 YY1 GATA3 TRIM24 MMP24 MMP24-AS1 CEP250 EDEM2 LOC102725201 RBM39 SPAG4 ENSG00000279253 GC20M035263
GH20F035317 1.3 VISTA FANTOM5 Ensembl ENCODE 14.8 +93.0 93001 5.3 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 FOS ZNF263 SP3 UQCC1 RBM12 EIF6 FAM83C AAR2 CPNE1 MMP24 NCOA6 FAM83C-AS1 MMP24-AS1
GH20F035199 0.9 Ensembl ENCODE 12.1 -26.5 -26455 0.8 JUN BHLHE40 CEBPB ELF1 EP300 NR2F2 JUND ZNF316 GATA3 MAFF MMP24 ENSG00000201151 MIR499A NCOA6 GC20M035202 RNA5SP483
GH20F035257 0.7 Ensembl 11.4 +30.9 30948 0.4 SCRT1 CEBPB REST ARID1B ZNF664 ZFHX2 JUND IKZF1 RCOR1 EGR2 MMP24 MMP24-AS1 EIF6 FAM83C-AS1 FAM83C ENSG00000201151 ENSG00000279253 GC20M035263
GH20F035301 1.4 FANTOM5 Ensembl ENCODE 11 +79.4 79354 9.0 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UQCC1 NCOA6 GDF5 RPL36P4 MMP24-AS1 EDEM2 MMP24 CEP250 MIR1289-1 RBM12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MMP24 on UCSC Golden Path with GeneCards custom track

Promoters for MMP24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001836969 246 1001 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF143

Genomic Location for MMP24 Gene

Chromosome:
20
Start:
35,226,654 bp from pter
End:
35,277,663 bp from pter
Size:
51,010 bases
Orientation:
Plus strand

Genomic View for MMP24 Gene

Genes around MMP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP24 Gene

Proteins for MMP24 Gene

  • Protein details for MMP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5R2-MMP24_HUMAN
    Recommended name:
    Matrix metalloproteinase-24
    Protein Accession:
    Q9Y5R2
    Secondary Accessions:
    • B7ZBG8
    • Q9H440

    Protein attributes for MMP24 Gene

    Size:
    645 amino acids
    Molecular mass:
    73231 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain). Interacts with GRIP1 and GRIP2 (By similarity).

neXtProt entry for MMP24 Gene

Post-translational modifications for MMP24 Gene

  • Cleaved by a furin endopeptidase in the trans-Golgi network.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP24 Gene

Antibody Products

  • R&D Systems Antibodies for MMP24 (MMP-24/MT5-MMP)
  • Abcam antibodies for MMP24
  • Cloud-Clone Corp. Antibodies for MMP24

Domains & Families for MMP24 Gene

Gene Families for MMP24 Gene

Suggested Antigen Peptide Sequences for MMP24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5R2

UniProtKB/Swiss-Prot:

MMP24_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans-Golgi network.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP24: view

Function for MMP24 Gene

Molecular function for MMP24 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 24,membrane type (MT),expressed in brain,kidney,pancreas and lung activator of progelalinase,overexpressed in brain tumor,involved in neurogenesis
UniProtKB/Swiss-Prot Function:
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Enzyme Numbers (IUBMB) for MMP24 Gene

Gene Ontology (GO) - Molecular Function for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0008047 enzyme activator activity TAS 10363975
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP24: view
genes like me logo Genes that share phenotypes with MMP24: view

Animal Models for MMP24 Gene

MGI Knock Outs for MMP24:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP24

miRNA for MMP24 Gene

miRTarBase miRNAs that target MMP24

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP24 Gene

Localization for MMP24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP24 Gene

Matrix metalloproteinase-24: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.
Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP24 Gene COMPARTMENTS Subcellular localization image for MMP24 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS,TAS --
genes like me logo Genes that share ontologies with MMP24: view

Pathways & Interactions for MMP24 Gene

genes like me logo Genes that share pathways with MMP24: view

Pathways by source for MMP24 Gene

Gene Ontology (GO) - Biological Process for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS,TAS --
GO:0007155 cell adhesion IEA --
GO:0010001 glial cell differentiation IEA,ISS --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0044331 cell-cell adhesion mediated by cadherin IEA,ISS --
genes like me logo Genes that share ontologies with MMP24: view

No data available for SIGNOR curated interactions for MMP24 Gene

Drugs & Compounds for MMP24 Gene

(6) Drugs for MMP24 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(2) Additional Compounds for MMP24 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
TMI 1
287403-39-8

(5) Tocris Compounds for MMP24 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP24: view

Transcripts for MMP24 Gene

mRNA/cDNA for MMP24 Gene

Unigene Clusters for MMP24 Gene

Matrix metallopeptidase 24 (membrane-inserted):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP24 Gene

No ASD Table

Relevant External Links for MMP24 Gene

GeneLoc Exon Structure for
MMP24
ECgene alternative splicing isoforms for
MMP24

Expression for MMP24 Gene

mRNA expression in normal human tissues for MMP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP24 Gene

This gene is overexpressed in Brain - Cerebellum (x8.4) and Brain - Cerebellar Hemisphere (x7.0).

Protein differential expression in normal tissues from HIPED for MMP24 Gene

This gene is overexpressed in Placenta (34.4), Liver (14.6), Pancreas (12.4), and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP24 Gene



Protein tissue co-expression partners for MMP24 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP24 Gene:

MMP24

SOURCE GeneReport for Unigene cluster for MMP24 Gene:

Hs.715494

mRNA Expression by UniProt/SwissProt for MMP24 Gene:

Q9Y5R2-MMP24_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
genes like me logo Genes that share expression patterns with MMP24: view

Primer Products

Orthologs for MMP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP24 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP24 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP24 34 35
  • 93.91 (n)
dog
(Canis familiaris)
Mammalia MMP24 34 35
  • 93.5 (n)
mouse
(Mus musculus)
Mammalia Mmp24 34 16 35
  • 91.36 (n)
rat
(Rattus norvegicus)
Mammalia Mmp24 34
  • 90.48 (n)
chicken
(Gallus gallus)
Aves MMP24 34 35
  • 78.74 (n)
lizard
(Anolis carolinensis)
Reptilia MMP24 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp24 34
  • 74.85 (n)
zebrafish
(Danio rerio)
Actinopterygii mmp24 34 35
  • 75.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 36
  • 37 (a)
Mmp2 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 36
  • 41 (a)
H19M22.3a 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7631 34
Species where no ortholog for MMP24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP24 Gene

ENSEMBL:
Gene Tree for MMP24 (if available)
TreeFam:
Gene Tree for MMP24 (if available)

Paralogs for MMP24 Gene

(18) SIMAP similar genes for MMP24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MMP24: view

Variants for MMP24 Gene

Sequence variations from dbSNP and Humsavar for MMP24 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1042971 -- 35,276,007(+) GGGTT(C/T)ATCAA intron-variant, utr-variant-3-prime
rs10710875 -- 35,236,995(+) AAAAA(-/A)TCACT intron-variant
rs111278427 -- 35,246,400(+) TGAAC(C/T)CCGGA intron-variant
rs111325381 -- 35,263,633(+) GCTTG(A/G)GAGGC intron-variant
rs111359130 -- 35,261,445(+) GGACA(C/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP24 Gene

Variant ID Type Subtype PubMed ID
esv3645713 CNV loss 21293372
nsv1059168 CNV loss 25217958
nsv1073056 CNV deletion 25765185
nsv1136327 CNV deletion 24896259
nsv585943 CNV loss 21841781
nsv954028 CNV deletion 24416366

Variation tolerance for MMP24 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP24 Gene

Disorders for MMP24 Gene

Relevant External Links for MMP24

Genetic Association Database (GAD)
MMP24
Human Genome Epidemiology (HuGE) Navigator
MMP24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP24

No disorders were found for MMP24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP24 Gene

Publications for MMP24 Gene

  1. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase a overexpressed in brain tumors. (PMID: 10363975) Llano E. … Lopez-Otin C. (Cancer Res. 1999) 2 3 4 22 64
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  3. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B. … Abel L. (Gut 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64

Products for MMP24 Gene

Sources for MMP24 Gene

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