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Aliases for MMP23B Gene

Aliases for MMP23B Gene

  • Matrix Metallopeptidase 23B 2 3 5
  • Femalysin 2 3 4
  • Matrix Metalloproteinase In The Female Reproductive Tract 2 3
  • Matrix Metalloproteinase 23B 2 3
  • Matrix Metalloproteinase-21 3 4
  • Matrix Metalloproteinase-22 3 4
  • Matrix Metalloproteinase 22 2 3
  • MMP-21 3 4
  • MIFR-1 3 4
  • MMP-22 3 4
  • MMP-23 3 4
  • MMP22 3 4
  • MMP23A MMP23B 4
  • EC 3.4.24.- 4
  • MMP23A 3
  • MMP21 4
  • MIFR 3

External Ids for MMP23B Gene

Previous HGNC Symbols for MMP23B Gene

  • MMP22

Previous GeneCards Identifiers for MMP23B Gene

  • GC01P001188
  • GC01P001437
  • GC01P001500
  • GC01P001580
  • GC01P9N0048
  • GC01P001558
  • GC01P001559
  • GC01P000843
  • GC01P001567

Summaries for MMP23B Gene

Entrez Gene Summary for MMP23B Gene

  • This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23B Gene

MMP23B (Matrix Metallopeptidase 23B) is a Protein Coding gene. Among its related pathways are Matrix Metalloproteinases and GPCR Pathway. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP23B Gene

  • Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Tocris Summary for MMP23B Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP23B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP23B Gene

Genomics for MMP23B Gene

Regulatory Elements for MMP23B Gene

Enhancers for MMP23B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MMP23B on UCSC Golden Path with GeneCards custom track

Promoters for MMP23B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP23B on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP23B Gene

Chromosome:
1
Start:
1,632,095 bp from pter
End:
1,701,810 bp from pter
Size:
69,716 bases
Orientation:
Plus strand

Genomic View for MMP23B Gene

Genes around MMP23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23B Gene

Proteins for MMP23B Gene

  • Protein details for MMP23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75900-MMP23_HUMAN
    Recommended name:
    Matrix metalloproteinase-23
    Protein Accession:
    O75900
    Secondary Accessions:
    • A2AGN0
    • A2AGN1
    • O75894
    • O75895
    • Q5QPQ8
    • Q76P96
    • Q7LDM6
    • Q7LDM7
    • Q9UBR9
    • Q9UJK8

    Protein attributes for MMP23B Gene

    Size:
    390 amino acids
    Molecular mass:
    43935 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP23B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP23B Gene

Proteomics data for MMP23B Gene at MOPED

Post-translational modifications for MMP23B Gene

Antibody Products

No data available for DME Specific Peptides for MMP23B Gene

Domains & Families for MMP23B Gene

Suggested Antigen Peptide Sequences for MMP23B Gene

Graphical View of Domain Structure for InterPro Entry

O75900

UniProtKB/Swiss-Prot:

MMP23_HUMAN :
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Belongs to the peptidase M10A family.
Domain:
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 ShKT domain.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP23B: view

Function for MMP23B Gene

Molecular function for MMP23B Gene

GENATLAS Biochemistry:
matrix metalloproteinase 23B,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by TIMP2.
UniProtKB/Swiss-Prot Function:
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Enzyme Numbers (IUBMB) for MMP23B Gene

Gene Ontology (GO) - Molecular Function for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,NAS 9740677
GO:0008237 metallopeptidase activity IEA,NAS 9740677
genes like me logo Genes that share ontologies with MMP23B: view
genes like me logo Genes that share phenotypes with MMP23B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP23B

CRISPR Products

miRNA for MMP23B Gene

miRTarBase miRNAs that target MMP23B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP23B Gene

Localization for MMP23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP23B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP23B Gene COMPARTMENTS Subcellular localization image for MMP23B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 9988691
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MMP23B: view

Pathways & Interactions for MMP23B Gene

genes like me logo Genes that share pathways with MMP23B: view

Pathways by source for MMP23B Gene

1 GeneTex pathway for MMP23B Gene
1 BioSystems pathway for MMP23B Gene

Interacting Proteins for MMP23B Gene

Gene Ontology (GO) - Biological Process for MMP23B Gene

None

No data available for SIGNOR curated interactions for MMP23B Gene

Drugs & Compounds for MMP23B Gene

(1) Drugs for MMP23B Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4

(4) Additional Compounds for MMP23B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP23B Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP23B: view

Transcripts for MMP23B Gene

Unigene Clusters for MMP23B Gene

Matrix metallopeptidase 23B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23B Gene

No ASD Table

Relevant External Links for MMP23B Gene

GeneLoc Exon Structure for
MMP23B
ECgene alternative splicing isoforms for
MMP23B

Expression for MMP23B Gene

mRNA expression in normal human tissues for MMP23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP23B Gene

This gene is overexpressed in Ovary (x6.2), Artery - Aorta (x4.7), and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for MMP23B Gene

This gene is overexpressed in Testis (35.6), Lung (11.5), Prostate (9.2), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP23B Gene



SOURCE GeneReport for Unigene cluster for MMP23B Gene Hs.192316

mRNA Expression by UniProt/SwissProt for MMP23B Gene

O75900-MMP23_HUMAN
Tissue specificity: Predominantly expressed in ovary, testis and prostate.
genes like me logo Genes that share expression patterns with MMP23B: view

Protein tissue co-expression partners for MMP23B Gene

- Elite partner

Primer Products

Orthologs for MMP23B Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP23B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP23B 35
  • 87.92 (n)
  • 88.17 (a)
MMP23B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP23B 35
  • 85.9 (n)
  • 89.49 (a)
MMP23B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp23 35
  • 80.12 (n)
  • 84.32 (a)
Mmp23 16
Mmp23 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP23B 35
  • 98.99 (n)
  • 98.65 (a)
MMP23B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp23 35
  • 80.28 (n)
  • 84.5 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP23B 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP23B 36
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP23B 35
  • 66.19 (n)
  • 71.92 (a)
MMP23B 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP23B 36
  • 1 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp23b 35
  • 64.09 (n)
  • 68.42 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882601 35
  • 69.84 (n)
  • 71.43 (a)
MMP23B 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 14 (a)
ManyToMany
zmp-1 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToOne
Species with no ortholog for MMP23B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP23B Gene

ENSEMBL:
Gene Tree for MMP23B (if available)
TreeFam:
Gene Tree for MMP23B (if available)

Paralogs for MMP23B Gene

Paralogs for MMP23B Gene

(3) SIMAP similar genes for MMP23B Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for MMP23B Gene

genes like me logo Genes that share paralogs with MMP23B: view

Variants for MMP23B Gene

Sequence variations from dbSNP and Humsavar for MMP23B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1061964 -- 1,632,815(+) GCGGT(C/G)CCCCC reference, synonymous-codon
rs2235535 -- 1,634,663(+) CTCCT(C/G)GCTCA downstream-variant-500B
rs4648593 -- 1,633,986(+) CCCGA(C/T)AGGAT intron-variant
rs28445304 -- 1,631,603(+) ACCCA(C/T)GCACC upstream-variant-2KB
rs28451771 -- 1,631,710(+) GCGTC(C/T)CCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP23B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
esv2661270 CNV Deletion 23128226
esv2659399 CNV Deletion 23128226
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545

Variation tolerance for MMP23B Gene

Gene Damage Index Score: 0.07; 1.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP23B Gene

HapMap Linkage Disequilibrium report
MMP23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP23B Gene

Disorders for MMP23B Gene

Relevant External Links for MMP23B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP23B

No disorders were found for MMP23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP23B Gene

Publications for MMP23B Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R. … Kidd V.J. (Genomics 1998) 2 3 4 23 67
  2. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians. (PMID: 19222855) Fu L. … Shi Y.B. (BMC Genomics 2009) 23

Products for MMP23B Gene

Sources for MMP23B Gene

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