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MMP23B Gene

protein-coding   GIFtS: 57
GCID: GC01P001567

Matrix Metallopeptidase 23B

(Previous name: matrix metalloproteinase 23B)
(Previous symbol: MMP22)
  See MMP23B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 23B1 2     MMP-212 3
MMP221 2 3 5     MMP-222 3
Matrix Metalloproteinase 23B1 2     MMP-232 3
femalysin1 2     MIFR2
Matrix Metalloproteinase 221 2     MMP23A2
Matrix Metalloproteinase In The Female Reproductive Tract1 2     Matrix Metalloproteinase-232
Matrix Metalloproteinase-212 3     EC 3.4.24.-3
Matrix Metalloproteinase-222 3     Femalysin3
MIFR-12 3     MMP213

External Ids:    HGNC: 71711   Entrez Gene: 85102   Ensembl: ENSG000001894097   OMIM: 6033215   UniProtKB: O759003   

Export aliases for MMP23B gene to outside databases

Previous GC identifers: GC01P001188 GC01P001437 GC01P001500 GC01P001580 GC01P9N0048 GC01P001558 GC01P001559 GC01P000843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP23B Gene:
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated
region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown
of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and
tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the
more telomeric copy of the duplicated region. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP23B Gene:
MMP23B (matrix metallopeptidase 23B) is a protein-coding gene. Diseases associated with MMP23B include transient hypogammaglobulinemia, and choanal atresia. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900
Function: Protease. May regulate the surface expression of some potassium channels by retaining them in the
endoplasmic reticulum (By similarity)

summary for MMP23B Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP23B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP23B gene promoter:
         c-Fos   AP-1   Tal-1   p53   c-Jun   C/EBPalpha   Roaz   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP23B promoter sequence
   Search Chromatin IP Primers for MMP23B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP23B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.3

MMP23B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP23B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001567:  view genomic region     (about GC identifiers)

Start:
1,567,474 bp from pter      End:
1,570,639 bp from pter
Size:
3,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900 (See protein sequence)
Recommended Name: Matrix metalloproteinase-23 precursor  
Size: 390 amino acids; 43935 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: A2AGN0 A2AGN1 O75894 O75895 Q5QPQ8 Q76P96 Q7LDM6 Q7LDM7 Q9UBR9 Q9UJK8
Alternative splicing: 3 isoforms:  O75900-1   O75900-2   O75900-3   

Explore the universe of human proteins at neXtProt for MMP23B: NX_O75900

Explore proteomics data for MMP23B at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Proteolytic cleavage might yield an active form (By similarity)1
  • Glycosylation2 at Asn92, Asn148, Asn232, Asn316
  • Modification sites at PhosphoSitePlus

  • See MMP23B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008914.1  
    ENSEMBL proteins: 
     ENSP00000348308   ENSP00000424976   ENSP00000423780   ENSP00000367945   ENSP00000426293  
     ENSP00000405867   ENSP00000426857   ENSP00000462142  

    MMP23B Human Recombinant Protein Products:

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    Novus Biologicals MMP23B Lysate
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    Cloud-Clone Corp. Proteins for MMP23B

     
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    antibodies-online proteins for MMP23B (3 products) 

     
    antibodies-online peptides for MMP23B

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    antibodies-online antibodies for MMP23B (78 products) 

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    antibodies-online kits for MMP23B (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP23
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 9):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR013783 Ig-like_fold
     IPR006026 Peptidase_Metallo
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry O75900

    ProtoNet protein and cluster: O75900

    2 Blocks protein domains:
    IPB003582 Metridin-like ShK toxin
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900
    Domain: The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar
    range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity)
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 ShKT domain


    Find genes that share domains with MMP23B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP23_HUMAN, O75900
    Function: Protease. May regulate the surface expression of some potassium channels by retaining them in the
    endoplasmic reticulum (By similarity)
    Enzyme regulation: Inhibited by TIMP2 (By similarity)

         Genatlas biochemistry entry for MMP23B:
    matrix metalloproteinase 23B,regulator in matrix remodeling,with three alternatively spliced isoforms
    A,B,C,expressed in ovary,testis,prostate

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity NAS9740677
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity NAS9740677
    GO:0008270zinc ion binding NAS9988691
         
    Find genes that share ontologies with MMP23B           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Mmp23 (no phenotypes)

    Find genes that share phenotypes with MMP23B           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MMP23B

    miRNA
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    miRTarBase miRNAs that target MMP23B:
    hsa-mir-197-3p (MIRT004178)

    Block miRNA regulation of human, mouse, rat MMP23B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP23B:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidMMP23B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MMP23B

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP23B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP23B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP23_HUMAN, O75900: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity).
    Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also
    exist (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS9740677
    GO:0005622intracellular NAS9988691
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MMP23B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP23B About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP23B
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP23B
        Matrix Metalloproteinases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP23B
    Interactions:

        Search GeneGlobe Interaction Network for MMP23B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MMP23B (ENSP000003483084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLRXENSP000002378584STRING: ENSP00000237858
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000003reproduction IEP9988691
    GO:0006508proteolysis IDA9988691

    Find genes that share ontologies with MMP23B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP23B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP23B gene: 
    NM_006983.1  

    Unigene Cluster for MMP23B:

    Matrix metallopeptidase 23B
    Hs.192316  [show with all ESTs]
    Unigene Representative Sequence: BM805143
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356026(uc001agp.3) ENST00000472264 ENST00000512731 ENST00000378675(uc001agq.3 uc001agr.3 uc009vki.3)
    ENST00000479814 ENST00000435358 ENST00000503792 ENST00000489782 ENST00000486400
    ENST00000490017
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MMP23B:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidMMP23B 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat MMP23B

    Additional mRNA sequence: 

    AB010961.1 AF056200.1 AJ005256.1 AK297700.1 BC025719.1 

    7 DOTS entries:

    DT.100778024  DT.452256  DT.121399135  DT.91831762  DT.100662335  DT.100021964  DT.92422118 

    Selected AceView cDNA sequences (see all 40):

    AF086353 BM679806 BX100332 BQ575307 CR608527 BX096766 BM930943 AF057061 
    AA151428 AI815030 BI517766 AF057062 BM717784 BI829304 AJ707857 BM544158 
    CB048617 BM796874 CF127824 BI518194 AB010961 AA626131 AI347985 AB010962 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP23B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGGCTCT
    MMP23B Expression
    About this image


    MMP23B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Brain (Nervous System)
             Cerebellum
    MMP23B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP23B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192316

    UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900
    Tissue specificity: Predominantly expressed in ovary, testis and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP23B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp231 , 5 matrix metallopeptidase 231, 5 80.12(n)1
    84.32(a)1
      4 (86.85 cM)5
    265611  NM_011985.21  NP_036115.11 
     1556506555 
    chicken
    (Gallus gallus)
    Aves MMP23B1 matrix metallopeptidase 23B 66.19(n)
    71.92(a)
      419407  XM_417569.2  XP_417569.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP23B6
    matrix metallopeptidase 23B
    1(a)
    1 ↔ 1
    GL343253.1(224859-226632)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp23b1 matrix metallopeptidase 23B 64.09(n)
    68.42(a)
      101733259  XM_004916150.1  XP_004916207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018826011 matrix metalloproteinase-23-like 69.84(n)
    71.43(a)
      101882601  XM_005172497.1  XP_005172554.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zmp-16
    H19M22.36
    Protein H19M22.3, isoform c
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    III(5926898-5932953) WBGene00006987
    III(2636405-2642848) WBGene00019212


    ENSEMBL Gene Tree for MMP23B (if available)
    TreeFam Gene Tree for MMP23B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP23B gene
    MMP212  MMP92  MMP22  MMP192  MMP262  ELSPBP12  
    3 SIMAP similar genes for MMP23B using alignment to 7 protein entries:     MMP23_HUMAN (see all proteins):
    MMP23A    mifr-2    MMP1

    Find genes that share paralogs with MMP23B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MMP23B
    PGOHUM00000251106 PGOHUM00000251107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MMP23B (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659399CNV Deletion23128226
    esv2661270CNV Deletion23128226
    nsv871940CNV Loss21882294
    dgv47n71CNV Loss21882294
    nsv871954CNV Loss21882294
    nsv870847CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    nsv871837CNV Loss21882294
    dgv46n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603321    OMIM disorders: --

    4 diseases for MMP23B:    
    About MalaCards
    transient hypogammaglobulinemia    choanal atresia    encephalomyelitis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for MMP23B:
    Transient hypogammaglobulinemia     Choanal atresia

    Find genes that share disorders with MMP23B           About GenesLikeMe


    Export disorders for MMP23B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP23B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MMP23B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PubMed id 9740677)1, 2, 3, 9 Gururajan R.... Kidd V.J. (Genomics 1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. (PubMed id 11328856)1, 2 Ohnishi J....Takahashi T. (Mol. Endocrinol. 2001)
    5. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. (PubMed id 9988691)1, 2 Velasco G....Lopez-Otin C. (J. Biol. Chem. 1999)
    6. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PubMed id 9750192)1, 3 Gururajan R.... Kidd V.J. (Genome Res. 1998)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure. (PubMed id 15483646)1 Gajecka M....Shaffer L.G. (Eur. J. Hum. Genet. 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. (PubMed id 10949161)1 Terp G.E....rgensen F.S. (amp 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8510 HGNC: 7171 AceView: MMP23B.1 Ensembl:ENSG00000189409 euGenes: HUgn8510
    ECgene: MMP23B H-InvDB: MMP23B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP23B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP23B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP23B gene:
    Search GeneIP for patents involving MMP23B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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