Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MMP23A Gene

Aliases for MMP23A Gene

  • Matrix Metallopeptidase 23A (Pseudogene) 2 3 5
  • Matrix Metalloproteinase 23A 2 3
  • Femalysin 3 4
  • MIFR-1 3 4
  • MMP21 3 4
  • Matrix Metalloproteinase In The Female Reproductive Tract 3
  • Matrix Metalloproteinase 23 Pseudogene 3
  • Matrix Metalloproteinase 21 3
  • Matrix Metallopeptidase 23A 2
  • Matrix Metalloproteinase-21 4
  • Matrix Metalloproteinase-22 4
  • MMP23A MMP23B 4
  • EC 3.4.24.- 4
  • MMP-21 4
  • MMP-22 4
  • MMP-23 4
  • MMP22 4
  • MIFR 3

External Ids for MMP23A Gene

Previous HGNC Symbols for MMP23A Gene

  • MMP21

Previous GeneCards Identifiers for MMP23A Gene

  • GC01U990215
  • GC01P001436
  • GC01P001579
  • GC01P000048
  • GC01P9N0059
  • GC01P001557
  • GC01P001619
  • GC01P000908

Summaries for MMP23A Gene

Entrez Gene Summary for MMP23A Gene

  • This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23A Gene

MMP23A (Matrix Metallopeptidase 23A (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for MMP23A Gene

  • Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP23A Gene

Genomics for MMP23A Gene

Regulatory Elements for MMP23A Gene

Enhancers for MMP23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001698 1 Ensembl dbSUPER 0.7 +1.3 1261 4.8 RING1 KLF1 USF1 PKNOX1 SUZ12 RBBP5 HIC1 ARID3A POLR2A PATZ1 MORN1 LOC100287934 CICP3 LINC01786 LOC100129534 LINC00115 ENSG00000240731 SLC35E2 ENSG00000272455 MIB2
GH01G001694 0.8 Ensembl dbSUPER 0.7 -4.8 -4816 0.6 ZNF362 MAZ SCRT2 ZBTB33 SLC35E2B MMP23A
GH01G001696 0.7 dbSUPER 0.7 -3.0 -2977 1.2 YY2 SREBF2 CDC5L REST HIC1 MCM7 HDAC2 BCL11A POLR2A SCRT2 CDK11B MMP23A SLC35E2B
GH01G001723 1.3 ENCODE dbSUPER 0.3 +24.4 24390 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 CDK11B CDK11A MMP23A
GH01G001712 0.8 dbSUPER 0.4 +14.8 14812 3.8 CTCF BCOR ATF1 TAL1 TCF12 ZNF316 RBAK EGR1 POLR2A NCOR1 LOC100129381 MIB2 CDK11B SLC35E2B ENSG00000272106 CDK11A MMP23A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP23A on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP23A Gene

Chromosome:
1
Start:
1,699,939 bp from pter
End:
1,701,808 bp from pter
Size:
1,870 bases
Orientation:
Plus strand

Genomic View for MMP23A Gene

Genes around MMP23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23A Gene

Proteins for MMP23A Gene

  • Protein details for MMP23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75900-MMP23_HUMAN
    Recommended name:
    Matrix metalloproteinase-23
    Protein Accession:
    O75900
    Secondary Accessions:
    • A2AGN0
    • A2AGN1
    • O75894
    • O75895
    • Q5QPQ8
    • Q76P96
    • Q7LDM6
    • Q7LDM7
    • Q9UBR9
    • Q9UJK8

    Protein attributes for MMP23A Gene

    Size:
    390 amino acids
    Molecular mass:
    43935 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP23A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP23A Gene

Post-translational modifications for MMP23A Gene

No data available for DME Specific Peptides for MMP23A Gene

Domains & Families for MMP23A Gene

Graphical View of Domain Structure for InterPro Entry

O75900

UniProtKB/Swiss-Prot:

MMP23_HUMAN :
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Belongs to the peptidase M10A family.
Domain:
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP23A: view

No data available for Suggested Antigen Peptide Sequences for MMP23A Gene

Function for MMP23A Gene

Molecular function for MMP23A Gene

GENATLAS Biochemistry:
matrix metalloproteinase 23A,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by TIMP2.
UniProtKB/Swiss-Prot Function:
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Enzyme Numbers (IUBMB) for MMP23A Gene

genes like me logo Genes that share phenotypes with MMP23A: view

Animal Model Products

miRNA for MMP23A Gene

miRTarBase miRNAs that target MMP23A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP23A Gene

Localization for MMP23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP23A Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MMP23A Gene

Pathways & Interactions for MMP23A Gene

SuperPathways for MMP23A Gene

No Data Available

Interacting Proteins for MMP23A Gene

Selected Interacting proteins: O75900-MMP23_HUMAN for MMP23A Gene via IID

Gene Ontology (GO) - Biological Process for MMP23A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MMP23A Gene

Drugs & Compounds for MMP23A Gene

(1) Drugs for MMP23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
genes like me logo Genes that share compounds with MMP23A: view

Transcripts for MMP23A Gene

mRNA/cDNA for MMP23A Gene

(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP23A Gene

Matrix metallopeptidase 23A (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23A Gene

No ASD Table

Relevant External Links for MMP23A Gene

GeneLoc Exon Structure for
MMP23A
ECgene alternative splicing isoforms for
MMP23A

Expression for MMP23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP23A Gene

mRNA differential expression in normal tissues according to GTEx for MMP23A Gene

This gene is overexpressed in Ovary (x5.7).

Protein differential expression in normal tissues from HIPED for MMP23A Gene

This gene is overexpressed in Testis (35.6), Lung (11.5), Prostate (9.2), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP23A Gene



Protein tissue co-expression partners for MMP23A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP23A Gene:

MMP23A

SOURCE GeneReport for Unigene cluster for MMP23A Gene:

Hs.671760

mRNA Expression by UniProt/SwissProt for MMP23A Gene:

O75900-MMP23_HUMAN
Tissue specificity: Predominantly expressed in ovary, testis and prostate.
genes like me logo Genes that share expression patterns with MMP23A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP23A Gene

Orthologs for MMP23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP23A Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4264 34
Species where no ortholog for MMP23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP23A Gene

ENSEMBL:
Gene Tree for MMP23A (if available)
TreeFam:
Gene Tree for MMP23A (if available)

Paralogs for MMP23A Gene

(2) SIMAP similar genes for MMP23A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP23A: view

No data available for Paralogs for MMP23A Gene

Variants for MMP23A Gene

Sequence variations from dbSNP and Humsavar for MMP23A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001223299 -- 1,702,242(+) GCTCC(C/T)CTCCT downstream-variant-500B
rs1002604896 -- 1,698,440(+) CCCCC(G/T)CCAGG intron-variant, upstream-variant-2KB
rs1004263891 -- 1,698,699(+) TTTTC(A/C)AGAAA intron-variant, upstream-variant-2KB
rs1004658658 -- 1,699,490(+) AGAAC(A/T)TAAAT downstream-variant-500B, upstream-variant-2KB
rs1008851456 -- 1,699,913(+) CCGAT(C/G)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP23A Gene

Variant ID Type Subtype PubMed ID
dgv2e199 CNV deletion 23128226
dgv2e214 CNV loss 21293372
dgv38n54 CNV gain 21841781
dgv39n54 CNV loss 21841781
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv4e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
dgv9n100 CNV loss 25217958
esv2659399 CNV deletion 23128226
esv2661270 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv2764265 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3577686 CNV loss 25503493
esv3585007 CNV loss 21293372
esv3585010 CNV loss 21293372
esv3585015 CNV gain 21293372
esv3891747 CNV loss 25118596
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv1160864 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv436343 CNV deletion 17901297
nsv442858 CNV gain+loss 18776908
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545026 CNV loss 21841781
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv834091 CNV loss 17160897
nsv950452 CNV deletion 24416366
nsv950516 CNV deletion 24416366

Relevant External Links for MMP23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MMP23A Gene

Disorders for MMP23A Gene

Relevant External Links for MMP23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP23A

No disorders were found for MMP23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP23A Gene

Publications for MMP23A Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R. … Kidd V.J. (Genomics 1998) 2 3 4 22 64
  2. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. (PMID: 11328856) Ohnishi J. … Takahashi T. (Mol. Endocrinol. 2001) 3 4 64
  3. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. (PMID: 9988691) Velasco G. … Lopez-Otin C. (J. Biol. Chem. 1999) 3 4 64
  4. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3 64
  5. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. (PMID: 19965868) Rangaraju S. … Chandy K.G. (J. Biol. Chem. 2010) 3 64

Products for MMP23A Gene

Sources for MMP23A Gene

Content
Loading form....