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Aliases for MMP23A Gene

Aliases for MMP23A Gene

  • Matrix Metallopeptidase 23A (Pseudogene) 2 3 5
  • Matrix Metalloproteinase 23A 2 3
  • Femalysin 3 4
  • MIFR-1 3 4
  • MMP21 3 4
  • Matrix Metalloproteinase In The Female Reproductive Tract 3
  • Matrix Metalloproteinase 23 Pseudogene 3
  • Matrix Metalloproteinase 21 3
  • Matrix Metallopeptidase 23A 2
  • Matrix Metalloproteinase-21 4
  • Matrix Metalloproteinase-22 4
  • MMP23A MMP23B 4
  • EC 3.4.24.- 4
  • MMP-21 4
  • MMP-22 4
  • MMP-23 4
  • MMP22 4
  • MIFR 3

External Ids for MMP23A Gene

Previous HGNC Symbols for MMP23A Gene

  • MMP21

Previous GeneCards Identifiers for MMP23A Gene

  • GC01U990215
  • GC01P001436
  • GC01P001579
  • GC01P000048
  • GC01P9N0059
  • GC01P001557
  • GC01P001619
  • GC01P000908

Summaries for MMP23A Gene

Entrez Gene Summary for MMP23A Gene

  • This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23A Gene

MMP23A (Matrix Metallopeptidase 23A (Pseudogene)) is a Pseudogene. Among its related pathways are Matrix Metalloproteinases.

UniProtKB/Swiss-Prot for MMP23A Gene

  • Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP23A Gene

Genomics for MMP23A Gene

Regulatory Elements for MMP23A Gene

Enhancers for MMP23A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MMP23A on UCSC Golden Path with GeneCards custom track

Promoters for MMP23A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP23A on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP23A Gene

1,699,939 bp from pter
1,701,808 bp from pter
1,870 bases
Plus strand

Genomic View for MMP23A Gene

Genes around MMP23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23A Gene

Proteins for MMP23A Gene

  • Protein details for MMP23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix metalloproteinase-23
    Protein Accession:
    Secondary Accessions:
    • A2AGN0
    • A2AGN1
    • O75894
    • O75895
    • Q5QPQ8
    • Q76P96
    • Q7LDM6
    • Q7LDM7
    • Q9UBR9
    • Q9UJK8

    Protein attributes for MMP23A Gene

    390 amino acids
    Molecular mass:
    43935 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP23A Gene


neXtProt entry for MMP23A Gene

Proteomics data for MMP23A Gene at MOPED

Post-translational modifications for MMP23A Gene

No data available for DME Specific Peptides for MMP23A Gene

Domains & Families for MMP23A Gene

Graphical View of Domain Structure for InterPro Entry



  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Belongs to the peptidase M10A family.
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 ShKT domain.
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP23A: view

No data available for Suggested Antigen Peptide Sequences for MMP23A Gene

Function for MMP23A Gene

Molecular function for MMP23A Gene

GENATLAS Biochemistry:
matrix metalloproteinase 23A,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by TIMP2.
UniProtKB/Swiss-Prot Function:
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Enzyme Numbers (IUBMB) for MMP23A Gene

genes like me logo Genes that share phenotypes with MMP23A: view

miRNA for MMP23A Gene

miRTarBase miRNAs that target MMP23A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP23A Gene

Localization for MMP23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP23A Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MMP23A Gene

Pathways & Interactions for MMP23A Gene

SuperPathways for MMP23A Gene

Superpath Contained pathways
1 Matrix Metalloproteinases
genes like me logo Genes that share pathways with MMP23A: view

Pathways by source for MMP23A Gene

1 BioSystems pathway for MMP23A Gene

Interacting Proteins for MMP23A Gene

Gene Ontology (GO) - Biological Process for MMP23A Gene


No data available for SIGNOR curated interactions for MMP23A Gene

Drugs & Compounds for MMP23A Gene

(1) Drugs for MMP23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
genes like me logo Genes that share compounds with MMP23A: view

Transcripts for MMP23A Gene

mRNA/cDNA for MMP23A Gene

(2) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP23A Gene

Matrix metallopeptidase 23A (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23A Gene

No ASD Table

Relevant External Links for MMP23A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP23A Gene

mRNA expression in normal human tissues for MMP23A Gene

mRNA differential expression in normal tissues according to GTEx for MMP23A Gene

This gene is overexpressed in Ovary (x5.7).

Protein differential expression in normal tissues from HIPED for MMP23A Gene

This gene is overexpressed in Testis (35.6), Lung (11.5), Prostate (9.2), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP23A Gene

SOURCE GeneReport for Unigene cluster for MMP23A Gene Hs.671760

mRNA Expression by UniProt/SwissProt for MMP23A Gene

Tissue specificity: Predominantly expressed in ovary, testis and prostate.
genes like me logo Genes that share expression patterns with MMP23A: view

Protein tissue co-expression partners for MMP23A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MMP23A Gene

Orthologs for MMP23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP23A Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4264 35
Species with no ortholog for MMP23A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP23A Gene

Gene Tree for MMP23A (if available)
Gene Tree for MMP23A (if available)

Paralogs for MMP23A Gene

(2) SIMAP similar genes for MMP23A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP23A: view

No data available for Paralogs for MMP23A Gene

Variants for MMP23A Gene

Sequence variations from dbSNP and Humsavar for MMP23A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_028948 -
rs389272 -- 1,698,343(+) CTCAA(C/T)TCCCC upstream-variant-2KB
rs398437 -- 1,699,127(+) AACTT(C/T)GTGTG upstream-variant-2KB
rs409146 -- 1,698,040(+) GGAGG(C/G)GCAGG upstream-variant-2KB
rs4648621 -- 1,698,022(+) AAAAC(A/G)GGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP23A Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
esv2661270 CNV Deletion 23128226
esv2659399 CNV Deletion 23128226
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545
esv2748696 CNV Deletion 23290073
nsv871749 CNV Gain+Loss 21882294
nsv870598 CNV Gain 21882294
dgv2e199 CNV Deletion 23128226
dgv3n67 CNV Gain 20364138
dgv49n71 CNV Loss 21882294
dgv50n71 CNV Gain 21882294
nsv871030 CNV Gain 21882294
dgv51n71 CNV Loss 21882294
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv442858 CNV CNV 18776908
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MMP23A Gene

Disorders for MMP23A Gene

Relevant External Links for MMP23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MMP23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP23A Gene

Publications for MMP23A Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R. … Kidd V.J. (Genomics 1998) 2 3 4 23 67
  2. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3
  3. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. (PMID: 19965868) Rangaraju S. … Chandy K.G. (J. Biol. Chem. 2010) 3
  4. Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness. (PMID: 18286480) HegedA1s L. … Eliceiri G.L. (J. Cell. Physiol. 2008) 23
  5. Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure. (PMID: 15483646) Gajecka M. … Shaffer L.G. (Eur. J. Hum. Genet. 2005) 3

Products for MMP23A Gene

Sources for MMP23A Gene