MMP23A Gene
pseudogene GIFtS: 49
GCID: GC01P001619
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matrix metallopeptidase 23A (pseudogene)(Previous names: matrix metalloproteinase 23A, matrix metallopeptidase 23A...)
(Previous symbol: MMP21)
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Aliases
for MMP23A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Matrix Metallopeptidase 23A (Pseudogene)1 2 | | Femalysin3 | | MMP211 2 3 5 | | MMP-213 | | MIFR1 2 5 | | MMP-223 | | MIFR-12 3 | | MMP-233 | | Matrix Metallopeptidase 23A1 | | MMP223 | | Matrix Metalloproteinase 23A1 | | Matrix Metalloproteinase-213 | | EC 3.4.24.-3 | | Matrix Metalloproteinase-223 |
| External Ids: | HGNC: 71701 | Entrez Gene: 85112 | Ensembl: ENSG000002159147 | OMIM: 6033205 | UniProtKB: O759003 |
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| | ORGUL members: | |
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| NONCODE:n405709 | |
Export aliases for MMP23A gene to outside databasesPrevious GC identifers: GC01U990215 GC01P001436 GC01P001579 GC01P000048 GC01P9N0059 GC01P001557 GC01P000908
Summaries
for MMP23A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MMP23A:
This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. Thispseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of theduplicated region. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900Function: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmicreticulum (By similarity)
 summary
for MMP23A: Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
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Genomic Views
for MMP23A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MMP23A gene promoter:
ER-alpha USF1 AML1a Tal-1 Nkx5-1 Tal-1beta E47 C/EBPalpha ITF-2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for MMP23A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP23A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.3MMP23A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P001619: view genomic region
(about GC identifiers)
Start:
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1,631,369 bp from pter |
End:
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1,633,249 bp from pter |
Size:
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1,881 bases |
Orientation:
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plus strand |
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Proteins
for MMP23A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900 (See
protein sequence)Recommended Name: Matrix metalloproteinase-23 precursor Size: 390 amino acids; 43935 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Membrane;Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist (Probable)
Secondary accessions: A2AGN0 A2AGN1 O75894 O75895 Q5QPQ8 Q76P96 Q7LDM6 Q7LDM7 Q9UBR9 Q9UJK8Alternative splicing: 3 isoforms: O75900-1 O75900-2 O75900-3 Explore the universe of human proteins at neXtProt for MMP23A: NX_O75900
Post-translational modifications:
N-glycosylated1
Proteolytic cleavage might yield an active form (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75900
MMP23A Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
MMP23A Antibody Products:
Assay Products for MMP23A: |
Protein
Domains /
Families
for MMP23A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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MMP23A for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O75900ProtoNet protein and cluster: O75900 2 Blocks protein families: IPB003582 Metridin-like ShK toxin IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900Domain: The toxin-like domain associates with, and blocks several potassium channels in the nanomolar to low micromolarrange. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity)Similarity: Belongs to the peptidase M10A familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for MMP23A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900Function: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmicreticulum (By similarity)Enzyme regulation: Inhibited by TIMP2 (By similarity) Genatlas biochemistry entry for MMP23A:matrix metalloproteinase 23A,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressedin ovary,testis,prostate
Enzyme Number (IUBMB): EC 3.4.24.-1
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP23A |
1 GenomeRNAi human phenotype for MMP23A:
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Pathways & Interactions
for MMP23A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Matrix Metalloproteinases | |
1  BioSystems Pathway for MMP23A
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMP23A
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Drugs & Compounds
for MMP23A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for MMP23A available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CP 471474 | Broad spectrum MMP inhibitor | [210755-45-6] | | Marimastat | Broad spectrum MMP inhibitor | [154039-60-8] | | ONO 4817 | Broad spectrum MMP inhibitor | [223472-31-9] | | Batimastat | Potent, broad spectrum MMP inhibitor | [130370-60-4] | | PD 166793 | Broad spectrum MMP inhibitor | [199850-67-4] |
1 DrugBank Compound for MMP23A About this table
Search CenterWatch for drugs/clinical trials and news about MMP23A
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Transcripts
for MMP23A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for MMP23A: Matrix metallopeptidase 23A (pseudogene) Hs.671760 Unigene Representative Sequence: NR_0029462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000234610 ENST00000412810(uc001ahi.1 uc009vko.1)
Additional cDNA sequence: AF086353.1 NR_002946.1 3 DOTS entries: DT.100662335 DT.452256 DT.100021964 24/40 AceView cDNA sequences (see all 40): BX096766 BQ575307 BM930943 CR608527 BX100332 AF086353 BM679806 BM544158 AJ707857 BI517766 BI829304 AA151428 AF057062 CF127824 CB048617 AF057061 BM717784 BM796874 AI815030 BI518194 AI284983 AB010961 NM_006983 BC025719
GeneLoc Exon Structure
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Expression
for MMP23A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MMP23A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MMP23A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP23A
SOURCE GeneReport for Unigene cluster: Hs.671760
UniProtKB/Swiss-Prot: MMP23_HUMAN, O75900Tissue specificity: Predominantly expressed in ovary, testis and prostate
SABiosciences Custom PCR Arrays for MMP23A
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP23A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MMP23A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP23A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP23A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP23A |
Orthologs
for MMP23A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for MMP23A gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
Omy.42642 |
Oncorhynchus mykiss transcribed sequence with moderate more |
77.79(n) |
|
BX858331.1 |
Species with no ortholog for MMP23A
ENSEMBL Gene Tree for MMP23A (if available)
TreeFam Gene Tree for MMP23A (if available) |
Paralogs
for MMP23A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MMP23A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MMP23A (1631369 - 1633249 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for MMP23A
11 CNVs: 2042 22925 38832 2295 30362 3276 0002 31596 84001 63709 74286 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MMP23A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MMP23A for disorders About GeneDecksing
OMIM gene information: 603320
OMIM disorders: --
4  diseases for MMP23A: About MalaCardsencephalomyelitis breast cancer arthritis prostatitis
Export disorders for MMP23A gene to outside databases
|
Publications
for MMP23A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MMP23A gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MMP23A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PubMed id 9740677)1, 2, 3, 9 Gururajan R.... Kidd V.J. (1998)
- Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. (PubMed id 11328856)1, 2 Ohnishi J....Takahashi T. (2001)
- Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. (PubMed id 9988691)1, 2 Velasco G....Lopez-Otin C. (1999)
- Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PubMed id 9750192)1, 3 Gururajan R....Kidd V.J. (1998)
- Potassium channel modulation by a toxin domain in mat rix metalloprotease 23. (PubMed id 19965868)1 Rangaraju S....Chandy K.G. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure. (PubMed id 15483646)1 Gajecka M....Shaffer L.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. (PubMed id 10949161)1 Terp G.E....Jorgensen F.S. (2000)
- Clinical potential of matrix metalloprotease inhibito rs in cancer therapy. (PubMed id 10852638)7 Heath E.I. and Grochow L.B. (2000)
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External Searches for MMP23A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MMP23A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MMP23A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MMP23A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MMP23A gene:
Search GeneIP for patents involving MMP23A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MMP23A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP23A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP23A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP23A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP23A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP23A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP23A |
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 | | | MMP23A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP23A |
|  |  |  | | | | ThermoFisher Antibodies for MMP23A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MMP23A |
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