MMP21 Gene
protein-coding GIFtS: 57
GCID: GC10M127445
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|
matrix metallopeptidase 21(Previous name: matrix metalloproteinase 21 )
| |
Aliases
for MMP21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Matrix Metallopeptidase 211 2 | | Matrix Metalloproteinase 211 2 | | MMP-212 3 | | Matrix Metalloproteinase-212 | | EC 3.4.24.-3 | | EC 3.4.248 |
Export aliases for MMP21 gene to outside databasesPrevious GC identifers: GC10M126430 GC10M126658 GC10M127496 GC10M127029 GC10M121144 |
Summaries
for MMP21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MMP21:
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in thebreakdown of extracellular matrix for both normal physiological processes, such as embryonic development,reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may playan important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MMP21_HUMAN, Q8N119Function: May have an important and specific function in tumor progression and embryogenesis. Cleavesalpha-1-antitrypsin
 summary
for MMP21: Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
Gene Wiki entry for MMP21
|
Genomic Views
for MMP21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MMP21 gene promoter:
Oct-B1 GATA-3 Meis-1b GATA-1 GATA-2 IRF-2 HSF2 SEF-1 (1) Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MMP21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.3MMP21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M127445: view genomic region
(about GC identifiers)
Start:
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127,455,022 bp from pter |
End:
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127,464,390 bp from pter |
Size:
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9,369 bases |
Orientation:
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minus strand |
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Proteins
for MMP21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MMP21_HUMAN, Q8N119 (See
protein sequence)Recommended Name: Matrix metalloproteinase-21 precursor Size: 569 amino acids; 65043 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Secreted (Potential)
Secondary accessions: Q5VZP9 Q8NG02Explore the universe of human proteins at neXtProt for MMP21: NX_Q8N119
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N119
4/5 DME Specific Peptides for MMP21 (Q8N119) (see all 5)
MMP21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_671724.1
ENSEMBL proteins: ENSP00000357798
Human Recombinant Protein Products for MMP21:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0031012 | extracellular matrix |
IEA | -- |
MMP21 for ontologies About GeneDecksing
MMP21 Antibody Products:
Assay Products for MMP21: |
Protein
Domains /
Families
for MMP21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MMP21 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8N119ProtoNet protein and cluster: Q8N119 1 Blocks protein family: IPB002477 Putative peptidoglycan binding domain 1
UniProtKB/Swiss-Prot: MMP21_HUMAN, Q8N119Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Belongs to the peptidase M10A familySimilarity: Contains 4 hemopexin-like domains |
Function
for MMP21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MMP21_HUMAN, Q8N119Function: May have an important and specific function in tumor progression and embryogenesis. Cleavesalpha-1-antitrypsin Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.242
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004222 | metalloendopeptidase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
MMP21 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MMP21:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MMP21 (NM_147191) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP21 |
|
Pathways & Interactions
for MMP21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Matrix Metalloproteinases | | | 2 | Integrin Pathway | | | 3 | GPCR Pathway | |
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP21
1  BioSystems Pathway for MMP21
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMP21
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MMP21 (ENSP000003577984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
MMP21 for ontologies About GeneDecksing
|
Drugs & Compounds
for MMP21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for MMP21 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CP 471474 | Broad spectrum MMP inhibitor | [210755-45-6] | | Marimastat | Broad spectrum MMP inhibitor | [154039-60-8] | | ONO 4817 | Broad spectrum MMP inhibitor | [223472-31-9] | | Batimastat | Potent, broad spectrum MMP inhibitor | [130370-60-4] | | PD 166793 | Broad spectrum MMP inhibitor | [199850-67-4] |
1 HMDB Compound for MMP21 About this table
1 DrugBank Compound for MMP21 About this table
Search CenterWatch for drugs/clinical trials and news about MMP21
|
Transcripts
for MMP21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MMP21 gene: NM_147191.1 Unigene Cluster for MMP21: Matrix metallopeptidase 21 Hs.314141 [show with all ESTs]Unigene Representative Sequence: NM_1471911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368808(uc001liu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MMP21 (NM_147191) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP21 |
Additional cDNA sequence: AF331526.1 AF520613.1 1 DOTS entry: DT.95198411 6 AceView cDNA sequences: NM_147191 AF331526 AF520613 BX280618 CD637483 AW665196
GeneLoc Exon Structure
|
Expression
for MMP21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MMP21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MMP21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP21
SOURCE GeneReport for Unigene cluster: Hs.314141
UniProtKB/Swiss-Prot: MMP21_HUMAN, Q8N119Tissue specificity: Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney,liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines
SABiosciences Custom PCR Arrays for MMP21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP21 |
Orthologs
for MMP21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MMP21 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for MMP21 (if available)
TreeFam Gene Tree for MMP21 (if available) |
Paralogs
for MMP21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MMP21 gene
- MMP23B2 MMP192 MMP72 MMP262
MMP21 for paralogs About GeneDecksing
|
Genomic Variants
for MMP21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MMP21 (127455022 - 127464390 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MMP21
1 CNV: 3825 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP21 |
|
Disorders
/ Diseases
for MMP21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MMP21 for disorders About GeneDecksing
OMIM gene information: 608416
OMIM disorders: --
10  diseases for MMP21: About MalaCardsencephalomyelitis arthritis asthma hepatocellular carcinoma
breast cancer neuronitis esophagitis adenocarcinoma
carcinoma pancreatitis
2 Novoseek disease relationships for MMP21 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
24.1 |
2 |
14691307 (1), 12490321 (1) |
| tumors |
8.63 |
2 |
14691307 (1), 12490321 (1) |
Genetic Association Database (GAD): MMP21
Human Genome Epidemiology (HuGE) Navigator: MMP21 (2 documents)
Export disorders for MMP21 gene to outside databases
|
Publications
for MMP21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MMP21 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with MMP21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer. (PubMed id 12490321)1, 2, 9 Ahokas K.... Saarialho-Kere U. (2002)
- The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer. (PubMed id 15015597)1, 4, 9 Shagisultanova E.I....Malkhosyan S.R. (2004)
- The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein. (PubMed id 12617721)1, 2 Marchenko G.N.... Strongin A.Y. (2003)
- Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes. (PubMed id 14691307)1, 9 Ahokas K....Saarialho-Kere U. (2003)
- MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture. (PubMed id 16984259)1, 9 Skoog T....Saarialho-Kere U. (2006)
- Identification of high-risk stage II and stage III co lorectal cancer by analysis of MMP-21 expression. (PubMed id 21656525)1 Wu T....Du X. (2011)
- MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. (PubMed id 19601983)1 Boyd S....Saarialho-Kere U. (2009)
- Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells. (PubMed id 18633436)1 Skoog T....Saarialho-Kere U. (2009)
- Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in M erkel cell carcinoma. (PubMed id 19921252)1 Suomela S....Saarialho-Kere U. (2009)
- No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. (PubMed id 18768525)1 Qiu W....He F. (2008)
|
External Searches for MMP21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MMP21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MMP21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MMP21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MMP21 gene:
Search GeneIP for patents involving MMP21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MMP21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MMP21 | | OriGene shRNA RFP for MMP21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP21 | | | OriGene Protein Over-expression Lysate for MMP21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MMP21 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MMP21 | | OriGene Custom Protein Services for MMP21 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP21 |
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 |  |  |  | |
| | | | Tocris compounds for MMP21 |
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 | | | MMP21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP21 |
|  |  |  |  | | | | ThermoFisher Antibodies for MMP21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP21 |
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