MMP20 Gene
protein-coding GIFtS: 64
GCID: GC11M102481
|
|
matrix metallopeptidase 20(Previous name: matrix metalloproteinase 20 (enamelysin) )
| |
Aliases
for MMP20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Matrix Metallopeptidase 201 2 | | EC 3.4.24.-3 | | Matrix Metalloproteinase 20 (Enamelysin)1 2 | | Enamelysin3 | | Enamel Metalloproteinase2 3 | | EC 3.4.248 | | MMP-202 3 | | EC 3.4.24.228 | | AI2A22 5 | | EC 3.4.24.358 | | Matrix Metalloproteinase-202 | | |
Export aliases for MMP20 gene to outside databasesPrevious GC identifers: GC11M104641 GC11M103804 GC11M101985 GC11M101952 GC11M098374 |
Summaries
for MMP20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MMP20:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated whencleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major proteincomponent of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene,which alters the normal splice pattern and results in premature termination of the encoded protein, has beenassociated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.(provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882Function: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromoleculescharacterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). Mayplay a central role in tooth enamel formation
 summary
for MMP20: Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
Gene Wiki entry for MMP20
|
Genomic Views
for MMP20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MMP20 gene promoter:
RP58 Pbx1a GCNF Lmo2 HNF-3beta AREB6 POU2F1 GCNF-1 POU2F1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MMP20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3MMP20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M102481: view genomic region
(about GC identifiers)
Start:
|
102,447,566 bp from pter |
End:
|
102,496,063 bp from pter |
Size:
|
48,498 bases |
Orientation:
|
minus strand |
|
Proteins
for MMP20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882 (See
protein sequence)Recommended Name: Matrix metalloproteinase-20 precursor Size: 483 amino acids; 54387 Da
Cofactor: Binds 2 zinc ions per subunit
Cofactor: Binds 2 calcium ions per subunit
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Developmental stage: Expression initiates prior to the onset of dentin mineralization and continues throughout thesecretory stage of amelogenesis
1 PDB 3D structure from  and Proteopedia  for MMP20:2JSD (3D)
Secondary accessions: Q6DKT9Explore the universe of human proteins at neXtProt for MMP20: NX_O60882
Post-translational modifications:
Autoactivates at least at the 107-Asn- -Tyr-108 site (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60882
4/11 DME Specific Peptides for MMP20 (O60882) (see all 11)
MMP20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004762.2
ENSEMBL proteins: ENSP00000260228 Reactome Protein details: O60882
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MMP20 for ontologies About GeneDecksing
MMP20 Antibody Products:
Assay Products for MMP20: |
Protein
Domains /
Families
for MMP20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MMP20 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O60882ProtoNet protein and cluster: O60882 3 Blocks protein families: IPB000585 Hemopexin repeat IPB001818 Matrixin IPB002477 Putative peptidoglycan binding domain 1
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Belongs to the peptidase M10A familySimilarity: Contains 4 hemopexin-like domains |
Function
for MMP20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882Function: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromoleculescharacterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). Mayplay a central role in tooth enamel formationCatalytic activity: Cleaves aggrecan at the 360-Asn- -Phe-361 siteEnzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.352 EC 3.4.242 EC 3.4.24.222
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MMP20 (NM_004771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP20 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MMP20 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Mmp20tm1Jdb for MMP20
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mmp20):
MMP20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MMP20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Collagen formation | | | 2 | Degradation of the extracellular matrix | | | 3 | Matrix Metalloproteinases | | | 4 | Integrin Pathway | | | 5 | GPCR Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MMP20
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP20
1  BioSystems Pathway for MMP20
5 
Reactome Pathways for MMP20
MMP20 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMP20
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for MMP20 (O608823 ENSP000002602284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MMP20 for ontologies About GeneDecksing
|
Drugs & Compounds
for MMP20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MMP20 for compounds About GeneDecksing
Compounds for MMP20 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CP 471474 | Broad spectrum MMP inhibitor | [210755-45-6] | | Marimastat | Broad spectrum MMP inhibitor | [154039-60-8] | | ONO 4817 | Broad spectrum MMP inhibitor | [223472-31-9] | | Batimastat | Potent, broad spectrum MMP inhibitor | [130370-60-4] | | PD 166793 | Broad spectrum MMP inhibitor | [199850-67-4] |
1 HMDB Compound for MMP20 About this table
2 DrugBank Compounds for MMP20 About this table
5 Novoseek chemical compound relationships for MMP20 gene About this table
Search CenterWatch for drugs/clinical trials and news about MMP20
|
Transcripts
for MMP20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MMP20 gene: NM_004771.3 Unigene Cluster for MMP20: Matrix metallopeptidase 20 Hs.591946 [show with all ESTs]Unigene Representative Sequence: NM_0047713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260228(uc001phc.3) ENST00000542305 ENST00000544938
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MMP20 (NM_004771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP20 |
Additional cDNA sequence: AJ296177.1 Y12779.1 2 DOTS entries: DT.86859878 DT.100742567 8 AceView cDNA sequences: Y12779 BX282654 AJ296177 NM_004771 AW593141 BI562315 BG187290 AA824656
GeneLoc Exon Structure
|
Expression
for MMP20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MMP20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAATGTGG
About this image
See MMP20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP20
SOURCE GeneReport for Unigene cluster: Hs.591946
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882Tissue specificity: Expressed specifically in the enamel organ
SABiosciences Custom PCR Arrays for MMP20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP20 |
Orthologs
for MMP20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MMP20 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for MMP20 (if available)
TreeFam Gene Tree for MMP20 (if available) |
Paralogs
for MMP20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MMP20 gene
- MMP132 MMP82 MMP142 MMP92 MMP162 MMP22 MMP252 MMP242
- MMP152 MMP112 MMP32 MMP272 MMP172 MMP102 MMP12
15 SIMAP similar genes for MMP20 using alignment to 1 protein entry: MMP20_HUMAN:MMP7 MMP1 MMP8 MMP12 MMP3 MMP13
MMP27 MMP10 MMP26 MMP24 MMP14 MMP16
MMP17 MMP11 MMP15
MMP20 for paralogs About GeneDecksing
|
Genomic Variants
for MMP20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MMP20 (102447566 - 102496063 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MMP20
1 CNV: 6895
3 Indels: 11044 39858 61181
Human Gene Mutation Database (HGMD): MMP20
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP20 |
|
Disorders
/ Diseases
for MMP20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MMP20 for disorders About GeneDecksing
OMIM gene information: 604629
OMIM disorders: 612529
UniProtKB/Swiss-Prot: MMP20_HUMAN, O60882
Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:612529]. AI2A2is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. Theteeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middlelayers of enamel
18  diseases for MMP20: About MalaCardsamelogenesis imperfecta amelogenesis imperfecta, type iia2 amelogenesis imperfecta hypomaturation type arthritis
encephalomyelitis refractive error dental fluorosis dentinogenesis imperfecta
tooth agenesis dentin dysplasia laryngeal squamous cell carcinoma squamous cell carcinoma
craniopharyngioma laryngitis rheumatoid arthritis carcinoma
adenocarcinoma pancreatitis
4 diseases from the University of Copenhagen DISEASES database for MMP20:Amelogenesis imperfecta Dental fluorosis Dentinogenesis imperfecta Dentin dysplasia 5 Novoseek disease relationships for MMP20 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MMP20 (10 documents)
Export disorders for MMP20 gene to outside databases
|
Publications
for MMP20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MMP20 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with MMP20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and structural and functional characterization of human enamelysin (MMP-20). (PubMed id 9398237)1, 2, 3, 9 Llano E.... Lopez-Otin C. (1997)
- Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). (PubMed id 10922468)1, 2, 9 Stracke J.O.... Knaeuper V. (2000)
- MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta. (PubMed id 15744043)1, 2, 9 Kim J.-W.... Hu J.C.-C. (2005)
- JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro. (PubMed id 17611094)1, 9 Zhang Y....Denbesten P.K. (2007)
- Expression and regulation of MMP-20 in human tongue carcinoma cells. (PubMed id 11706946)1, 9 Vaananen A....Salo T. (2001)
- Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. (PubMed id 18434575)1, 9 Tanimoto K....Li W. (2008)
- Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase. (PubMed id 17869250)2, 9 Arendt Y....Gonnelli L. (2007)
- MMP20 hemopexin domain mutation in amelogenesis imper fecta. (PubMed id 19966041)1, 9 Lee S.K....Kim J.W. (2010)
- Genetic variation in MMP20 contributes to higher carie s experience. (PubMed id 22330321)1 Tannure P.N....Vieira A.R. (2012)
- A multidisciplinary approach for the diagnosis of hypo calcified amelogenesis imperfecta in two Chilean families. (PubMed id 21504268)1 Urzua B....Cifuentes V. (2012)
|
External Searches for MMP20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MMP20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MMP20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MMP20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MMP20 gene:
Search GeneIP for patents involving MMP20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MMP20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MMP20 | | OriGene shRNA RFP for MMP20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP20 | | | OriGene Protein Over-expression Lysate for MMP20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MMP20 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MMP20 | | OriGene Custom Protein Services for MMP20 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP20 |
| |
 |  |  |  | |
| | | | Tocris compounds for MMP20 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MMP20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP20 |
|  |  |  | | | | ThermoFisher Antibodies for MMP20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP20 |
|
|
|
|
