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Aliases for MMP2 Gene

Aliases for MMP2 Gene

  • Matrix Metallopeptidase 2 2 3 5
  • Matrix Metalloproteinase-2 3 4
  • EC 3.4.24.24 4 63
  • CLG4A 3 4
  • MMP-2 3 4
  • TBE-1 3 4
  • Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase) 2
  • Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase) 3
  • Matrix Metalloproteinase-II 3
  • Collagenase Type IV-A 3
  • Neutrophil Gelatinase 3
  • 72 KDa Gelatinase 4
  • Gelatinase A 4
  • EC 3.4.24 63
  • MMP-II 3
  • Mona 3
  • CLG4 3

External Ids for MMP2 Gene

Previous HGNC Symbols for MMP2 Gene

  • CLG4
  • CLG4A

Previous GeneCards Identifiers for MMP2 Gene

  • GC16P045928
  • GC16P055478
  • GC16P055161
  • GC16P055291
  • GC16P054070
  • GC16P041400

Summaries for MMP2 Gene

Entrez Gene Summary for MMP2 Gene

  • This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for MMP2 Gene

MMP2 (Matrix Metallopeptidase 2) is a Protein Coding gene. Diseases associated with MMP2 include multicentric osteolysis, nodulosis, and arthropathy and torg winchester syndrome. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include serine-type endopeptidase activity and metallopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP2 Gene

  • Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.

  • PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.

  • Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Tocris Summary for MMP2 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP2 Gene

Genomics for MMP2 Gene

Regulatory Elements for MMP2 Gene

Genomic Location for MMP2 Gene

Chromosome:
16
Start:
55,389,700 bp from pter
End:
55,506,691 bp from pter
Size:
116,992 bases
Orientation:
Plus strand

Genomic View for MMP2 Gene

Genes around MMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP2 Gene

Proteins for MMP2 Gene

  • Protein details for MMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08253-MMP2_HUMAN
    Recommended name:
    72 kDa type IV collagenase
    Protein Accession:
    P08253
    Secondary Accessions:
    • B2R6U1
    • B4DWH3
    • E9PE45
    • Q9UCJ8

    Protein attributes for MMP2 Gene

    Size:
    660 amino acids
    Molecular mass:
    73882 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.

    Three dimensional structures from OCA and Proteopedia for MMP2 Gene

    Alternative splice isoforms for MMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP2 Gene

Proteomics data for MMP2 Gene at MOPED

Post-translational modifications for MMP2 Gene

  • Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
  • The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.
  • Glycosylation at Asn 573 and Asn 642
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP2 (MMP2)

Assay Products

  • Enzo Life Sciences assays for MMP2

Domains & Families for MMP2 Gene

Gene Families for MMP2 Gene

Suggested Antigen Peptide Sequences for MMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P08253

UniProtKB/Swiss-Prot:

MMP2_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 3 fibronectin type-II domains.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP2: view

Function for MMP2 Gene

Molecular function for MMP2 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed in inflammatory bowel diseases
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly- -Ile-Ala-Gly-Gln.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by histatin-3 1/24 (histatin-5).
UniProtKB/Swiss-Prot Function:
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
UniProtKB/Swiss-Prot Function:
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
UniProtKB/Swiss-Prot Function:
Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
UniProtKB/Swiss-Prot Induction:
Aspirin appears to inhibit expression.

Enzyme Numbers (IUBMB) for MMP2 Gene

LifeMap Function Summary for MMP2 Gene

During embryonic development, MMP2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,TAS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP2: view
genes like me logo Genes that share phenotypes with MMP2: view

Human Phenotype Ontology for MMP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MMP2 Gene

MGI Knock Outs for MMP2:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MMP2 Gene

Localization for MMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP2 Gene

Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Isoform 2: Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP2 Gene COMPARTMENTS Subcellular localization image for MMP2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytoskeleton 3
cytosol 3
endoplasmic reticulum 2
vacuole 2
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with MMP2: view

Pathways & Interactions for MMP2 Gene

genes like me logo Genes that share pathways with MMP2: view

SIGNOR curated interactions for MMP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001955 blood vessel maturation IEA --
GO:0006508 proteolysis IEA,IDA 15863497
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with MMP2: view

Drugs & Compounds for MMP2 Gene

(96) Drugs for MMP2 Gene - From: Novoseek, DrugBank, HMDB, DGIdb, ApexBio, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor, Target MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
Captopril Approved Pharma Inhibition, Inhibitor, Target, inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 29
SC-74020 Experimental Pharma Target 0
Halofuginone Investigational Pharma Target 5
AE-941 Investigational Pharma Target 0

(60) Additional Compounds for MMP2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP2: view

Drug Products

Transcripts for MMP2 Gene

Unigene Clusters for MMP2 Gene

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP2 Gene

No ASD Table

Relevant External Links for MMP2 Gene

GeneLoc Exon Structure for
MMP2
ECgene alternative splicing isoforms for
MMP2

Expression for MMP2 Gene

mRNA expression in normal human tissues for MMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP2 Gene

This gene is overexpressed in Amniocyte (49.4) and Serum (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMP2 Gene



SOURCE GeneReport for Unigene cluster for MMP2 Gene Hs.513617

mRNA Expression by UniProt/SwissProt for MMP2 Gene

P08253-MMP2_HUMAN
Tissue specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
genes like me logo Genes that share expression patterns with MMP2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MMP2 Gene

Orthologs for MMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP2 35
  • 99.24 (n)
  • 99.54 (a)
MMP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP2 36
  • 95 (a)
OneToOne
MMP2 35
  • 90.69 (n)
  • 94.99 (a)
dog
(Canis familiaris)
Mammalia MMP2 35
  • 91.48 (n)
  • 96.72 (a)
MMP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp2 36
  • 96 (a)
OneToOne
Mmp2 16
Mmp2 35
  • 89.44 (n)
  • 95.91 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp2 35
  • 88.43 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves MMP2 36
  • 82 (a)
OneToOne
MMP2 35
  • 75.53 (n)
  • 83.93 (a)
lizard
(Anolis carolinensis)
Reptilia MMP2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Mmp2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp2 35
  • 73.54 (n)
  • 81.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12093 35
zebrafish
(Danio rerio)
Actinopterygii mmp2 36
  • 72 (a)
OneToOne
mmp2 35
  • 72.19 (n)
  • 75.16 (a)
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 22 (a)
ManyToMany
zmp-1 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1986 36
  • 49 (a)
OneToOne
Species with no ortholog for MMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP2 Gene

ENSEMBL:
Gene Tree for MMP2 (if available)
TreeFam:
Gene Tree for MMP2 (if available)

Paralogs for MMP2 Gene

Paralogs for MMP2 Gene

(13) SIMAP similar genes for MMP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MMP2: view

Variants for MMP2 Gene

Sequence variations from dbSNP and Humsavar for MMP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17859943 - 55,493,161(+) AGGGG(C/T)CTCTC reference, missense
rs16955280 - 55,502,870(+) CCGTC(C/G)TGGAC reference, missense
VAR_032423 Multicentric osteolysis, nodulosis, and arthropathy (MONA)
VAR_032424 -
VAR_032425 Multicentric osteolysis, nodulosis, and arthropathy (MONA)

Variation tolerance for MMP2 Gene

Residual Variation Intolerance Score: 6.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP2 Gene

HapMap Linkage Disequilibrium report
MMP2
Human Gene Mutation Database (HGMD)
MMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP2 Gene

Disorders for MMP2 Gene

MalaCards: The human disease database

(104) MalaCards diseases for MMP2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
multicentric osteolysis, nodulosis, and arthropathy
  • mona
torg winchester syndrome
  • al-qeel sewairi syndrome
multicentric osteolysis of torg
  • torg syndrome
arthropathy
  • ankylosis of ankle and foot joint
corneal ulcer
- elite association - COSMIC cancer census association via MalaCards
Search MMP2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP2_HUMAN
  • Multicentric osteolysis, nodulosis, and arthropathy (MONA) [MIM:259600]: An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. {ECO:0000269 PubMed:11431697, ECO:0000269 PubMed:15691365, ECO:0000269 PubMed:16542393}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MMP2

Genetic Association Database (GAD)
MMP2
Human Genome Epidemiology (HuGE) Navigator
MMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP2
genes like me logo Genes that share disorders with MMP2: view

No data available for Genatlas for MMP2 Gene

Publications for MMP2 Gene

  1. Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. (PMID: 17435175) Sariahmetoglu M. … Schulz R. (FASEB J. 2007) 3 4 23 67
  2. A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line. (PMID: 12527923) Shinoda K. … Kudoh S. (Int. J. Oncol. 2003) 23 25 26
  3. Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases. (PMID: 11790786) Bernardo M.M. … Mobashery S. (J. Biol. Chem. 2002) 3 25 26
  4. Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding. (PMID: 19249761) Zhang X. … Lin J. (Fertil. Steril. 2010) 3 23
  5. 17beta-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. (PMID: 19861308) Mahmoodzadeh S. … Regitz-Zagrosek V. (Cardiovasc. Res. 2010) 3 23

Products for MMP2 Gene

  • Addgene plasmids for MMP2

Sources for MMP2 Gene

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