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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP2 Gene

protein-coding   GIFtS: 74
GCID: GC16P055424

Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase,...

(Previous names: matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase,...)
(Previous symbols: CLG4, CLG4A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type
IV Collagenase)1 2
     MONA2 5
CLG4A1 2 3 5     Matrix Metalloproteinase 2 (Gelatinase A, 72kD Gelatinase, 72kD Type IV
Collagenase)1
CLG41 2     Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV
Collagenase)1
Gelatinase A2 3     72 KDa Type IV Collagenase2
Matrix Metalloproteinase-22 3     MMP-II2
72 KDa Gelatinase2 3     Collagenase Type IV-A2
MMP-22 3     Matrix Metalloproteinase-II2
TBE-12 3     Neutrophil Gelatinase2
EC 3.4.24.243 8     EC 3.4.248

External Ids:    HGNC: 71661   Entrez Gene: 43132   Ensembl: ENSG000000872457   OMIM: 1203605   UniProtKB: P082533   

Export aliases for MMP2 gene to outside databases

Previous GC identifers: GC16P045928 GC16P055478 GC16P055161 GC16P055291 GC16P054070 GC16P041400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP2 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen,
the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown,
regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with
Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP2 Gene: 
MMP2 (matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)) is a protein-coding gene. Diseases associated with MMP2 include winchester syndrome, and multicentric osteolysis nephropathy, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and Metalloproteases in connective tissue degradation. GO annotations related to this gene include metalloendopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the
vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As
well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big
endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to
have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the
activity of GSK3beta. Cleaves GSK3beta in vitro
Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties
and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface
of blood vessels
Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by
inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF
transcriptional pathways

summary for MMP2 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP2 gene promoter:
         SRF   Sp1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13-q21

MMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055424:  view genomic region     (about GC identifiers)

Start:
55,423,612 bp from pter      End:
55,540,603 bp from pter
Size:
116,992 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 (See protein sequence)
Recommended Name: 72 kDa type IV collagenase precursor  
Size: 660 amino acids; 73882 Da
Cofactor: Binds 4 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Subunit: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3;
the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the
C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity.
Interacts with GSK3B
Subcellular location: Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus.
Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas.
Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
Subcellular location: Isoform 2: Cytoplasm. Mitochondrion
6/11 PDB 3D structures from and Proteopedia for MMP2 (see all 11):
1CK7 (3D)        1CXW (3D)        1EAK (3D)        1GEN (3D)        1GXD (3D)        1HOV (3D)    
Secondary accessions: B2R6U1 B4DWH3 E9PE45 Q9UCJ8
Alternative splicing: 3 isoforms:  P08253-1   P08253-2   P08253-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MMP2: NX_P08253

Explore proteomics data for MMP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro
  • UniProtKB: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal
    produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08253

  • 4/26 DME Specific Peptides for MMP2 (P08253) (see all 26)
     DGYPFDG  YNFFPRK  GEADIMI  GLLAHAF 

    MMP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MMP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001121363.1  NP_004521.1  

    ENSEMBL proteins: 
     ENSP00000461421   ENSP00000457949   ENSP00000219070   ENSP00000456096   ENSP00000444143  
     ENSP00000394237   ENSP00000456518   ENSP00000461915  
    Reactome Protein details: P08253
    Human Recombinant Protein Products for MMP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP2 (MMP-2)
    Enzo Life Sciences proteins for MMP2
    OriGene Purified Protein for MMP2
    OriGene Protein Over-expression Lysate for MMP2
    OriGene MassSpec for MMP2 
    OriGene Custom Protein Services for MMP2
    GenScript Custom Purified and Recombinant Proteins Services for MMP2
    Novus Biologicals MMP2 Proteins
    Novus Biologicals MMP2 Lysates
    Sino Biological Recombinant Protein for MMP2
    Sino Biological Cell Lysate for MMP2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA18492766
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    MMP2 for ontologies           About GeneDecksing



    MMP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP2
    R&D Systems Antibodies for MMP2 (MMP-2)
    Cell Signaling Technology (CST) Antibodies for MMP2 
    OriGene Antibodies for MMP2
    OriGene Custom Antibody Services for MMP2
    GenScript Custom Superior Antibodies Services for MMP2
    Novus Biologicals MMP2 Antibodies
    Abcam antibodies for MMP2
    Cloud-Clone Corp. Antibodies for MMP2 
    ThermoFisher Antibody for MMP2
    LSBio Antibodies in human, mouse, rat for MMP2 

    Assay Products for MMP2: 
    EMD Millipore Kits and Assays for the Analysis of MMP2
    OriGene Custom Assay Services for MMP2
    R&D Systems ELISAs for MMP2 (MMP-2)         (see all)
    GenScript MMP2-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for MMP2
    Cloud-Clone Corp. ELISAs for MMP2 
    Cloud-Clone Corp. CLIAs for MMP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP2 
    Cell-surface protein and extracellular matrix metalloproteinases

    5/11 InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P08253

    ProtoNet protein and cluster: P08253

    3 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 3 fibronectin type-II domains
    Similarity: Contains 4 hemopexin repeats


    MMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP2_HUMAN, P08253
    Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the
    vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As
    well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big
    endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to
    have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the
    activity of GSK3beta. Cleaves GSK3beta in vitro
    Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties
    and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface
    of blood vessels
    Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by
    inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF
    transcriptional pathways
    Catalytic activity: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like
    sequence Pro-Gln-Gly- -Ile-Ala-Gly-Gln
    Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5)
    Induction: Aspirin appears to inhibit expression

         Genatlas biochemistry entry for MMP2:
    matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen
    and intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed
    in inflammatory bowel diseases

         Enzyme Numbers (IUBMB): EC 3.4.24.241 2 EC 3.4.242

         Summary:
    During embryonic development, MMP2 as signaling molecule is secreted from the following cells: Septum Transversum Mesenchyme Cells in Septum Transversum It affects the following cells: Hepatoblasts in Liver Bud

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MMP2:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp2):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  normal  respiratory system  skeleton 
     tumorigenesis  vision/eye 

    MMP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp2tm1Ito for MMP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MMP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP2:
    hsa-mir-451 (MIRT005742), hsa-mir-29b (MIRT005570)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP2
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP2 (see all 27):
    hsa-miR-3164 hsa-miR-2110 hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-519a hsa-miR-511 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidMMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP2
    Sirion Biotech Customized adenovirus for overexpression of MMP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MMP2 (see all 12)
    OriGene ORF clones in mouse, rat for MMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MMP2 (NM_004530)
    Sino Biological Human cDNA Clone for MMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2
    Sirion Biotech Customized lentivirus for stable overexpression of MMP2 
                         Customized lentivirus expression plasmids for stable overexpression of MMP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP2
    LifeMap BioReagents: cell lines associated with MMP2: PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MMP2 About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    Metalloproteases in connective tissue degradation0.31
    3Degradation of collagen
    Extracellular matrix organization0.60
    Degradation of the extracellular matrix0.33
    Degradation of collagen0.40
    Extracellular matrix organization0.33
    Degradation of the extracellular matrix0.40
    Degradation of collagen0.33
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    Degradation of collagen0.79
    5Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for MMP2
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation
    Transcription P53 signaling pathway

    2 R&D Systems Pathways for MMP2
        A-beta Uptake & Degradation
    A-beta Plaque Formation & APP Metabolism

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP2 (see all 6)
        Glioma Invasiveness
    Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    3 Cell Signaling Technology (CST) Pathways for MMP2
        Angiogenesis
    Adhesion
    Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for MMP2
        Transcription Androgen Receptor nuclear signaling
    Transcription P53 signaling pathway
    Development EGFR signaling pathway
    Cell adhesion ECM remodeling

    5/14 BioSystems Pathways for MMP2 (see all 14)
        Matrix Metalloproteinases
    AGE/RAGE pathway
    IL-3 Signaling Pathway
    ATF-2 transcription factor network
    Plasma membrane estrogen receptor signaling


    5/12        Reactome Pathways for MMP2 (see all 12)
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Degradation of collagen
    Degradation of collagen
    Degradation of collagen
    Activation of Matrix Metalloproteinases


    5/6         Kegg Pathways  (Kegg details for MMP2) (see all 6):
        Leukocyte transendothelial migration
    GnRH signaling pathway
    Estrogen signaling pathway
    Pathways in cancer
    Proteoglycans in cancer


    MMP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for MMP2 (P082531, 3 ENSP000002190704) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL7P800983, ENSP000002003074I2D: score=3 STRING: ENSP00000200307
    COL1A1P024523, ENSP000002259644I2D: score=2 STRING: ENSP00000225964
    LCN2P801883, ENSP000002774804I2D: score=2 STRING: ENSP00000277480
    LGALS3P179313, ENSP000002543014I2D: score=2 STRING: ENSP00000254301
    THBS2P354423, ENSP000003557514I2D: score=2 STRING: ENSP00000355751
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001955blood vessel maturation IEA--
    GO:0001957intramembranous ossification IEA--
    GO:0006508proteolysis IEA--

    MMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMP2 for compounds           About GeneDecksing

    EMD Millipore small molecules for MMP2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MMP2

    Compounds for MMP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for MMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2targetinhibitor19057128 10328230 15993560 20184869 12381651 17308006
    Marimastat-- 154039-60-8targetinhibitor12527923 15748894 11790786 15056115 11752352 10460642
    SC-74020SC 74020 (see all 2)--target--17139284 17016423

    1 IUPHAR Ligand for MMP2 (MMP2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    ARP100
    InhibitorInhibition16483784

    10/136 Novoseek inferred chemical compound relationships for MMP2 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 88.6 110 9413149 (4), 8292337 (3), 10491398 (3), 11431735 (2) (see all 82)
    (4-aminophenyl)mercuric acetate 80 23 1480033 (3), 2269296 (2), 9628251 (1), 7896811 (1) (see all 9)
    batimastat 78.7 10 9816289 (1), 11598905 (1), 10585576 (1), 11276015 (1) (see all 7)
    ilomastat 78.4 18 17512742 (2), 18665992 (2), 18465841 (1), 20299089 (1) (see all 10)
    vegf 75.7 623 16584583 (8), 16875630 (6), 16124061 (6), 16962110 (6) (see all 99)
    marimastat 67 4 12405288 (1), 12527923 (1), 19735728 (1)
    prinomastat 64.5 9 11060800 (1), 16483784 (1), 20215503 (1), 10415735 (1) (see all 5)
    cgs-27023a 63 2 15080939 (1), 11948136 (1)
    col 3 61 10 12850461 (3), 16205320 (2), 11469893 (1), 11320090 (1) (see all 7)
    hydroxamate 59.5 17 12147339 (2), 12475252 (1), 15781326 (1), 9548812 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about MMP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MMP2 gene (2 alternative transcripts): 
    NM_001127891.1  NM_004530.4  

    Unigene Cluster for MMP2:

    Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
    Hs.513617  [show with all ESTs]
    Unigene Representative Sequence: NM_004530
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570308 ENST00000568715 ENST00000219070(uc002ehz.4 uc010vhd.2 uc010ccc.3)
    ENST00000564864 ENST00000543485 ENST00000437642 ENST00000570283 ENST00000566564

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK057680.1 AK301536.1 AK310314.1 AK312711.1 AL832088.1 BC002576.2 DQ385623.1 J03210.1 
    X58968.1 

    24/35 DOTS entries (see all 35):

    DT.95130460  DT.100652571  DT.75124861  DT.92058175  DT.100762889  DT.101985660  DT.92462977  DT.100637823 
    DT.120668918  DT.120668959  DT.120668954  DT.91892990  DT.95336528  DT.100646179  DT.120668946  DT.120669002 
    DT.95091235  DT.120668909  DT.120668975  DT.92462967  DT.92462969  DT.92462976  DT.100722515  DT.120668915 

    24/601 AceView cDNA sequences (see all 601):

    CA416979 CA412514 AI751579 CR609745 CB216824 BP345628 BI092637 BM662474 
    AA235605 CF126102 CO397029 BX386175 AA377536 BU158122 CA414312 CO245644 
    BM725839 AA378895 BM727669 AA369008 BU145691 AA327422 CA414284 BQ670411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP2 expression in normal human tissues (normalized intensities)      MMP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATGTCA
    MMP2 Expression
    About this image


    MMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Olfactory Bulb   
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Intervertebral Disc Nucleus Pulposus Cells Sacral Intervertebral Disc
             Meckel's Cartilage
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Septum Transversum Mesenchyme Cells Septum Transversum
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...

    See MMP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP2

    SOURCE GeneReport for Unigene cluster: Hs.513617

    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Tissue specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas,
    breast and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including MMP2 (see all 14): 
              Osteogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MMP2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp21 , 5 matrix metallopeptidase 21, 5 89.44(n)1
    95.91(a)1
      8 (44.99 cM)5
    173901  NM_008610.21  NP_032636.11 
     928273285 
    chicken
    (Gallus gallus)
    Aves MMP21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) less 76.02(n)
    84.95(a)
      386583  NM_204420.2  NP_989751.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    LGc(2265381-2309677)
    African clawed frog
    (Xenopus laevis)
    Amphibia Mmp22 matrix metalloproteinase 2 76.61(n)    AY037943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp22 matrix metalloproteinase 2 77.22(n)   337179  AY324195.1 


    ENSEMBL Gene Tree for MMP2 (if available)
    TreeFam Gene Tree for MMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP2 gene
    MMP212  MMP23B2  MMP92  MMP192  MMP262  ELSPBP12  
    13 SIMAP similar genes for MMP2 using alignment to 5 protein entries:     MMP2_HUMAN (see all proteins):
    MMP15    MMP7    ELSPBP1    MMP1    MMP26    MMP10
    MMP3    MMP9    MMP13    MMP8    MMP17    mmp20
    MMP14

    MMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/830 SNPs in MMP2 are shown (see all 830)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0324234
    Torg-Winchester syndrome (TWS)4--see VAR_0324232 R H mis40--------
    VAR_0361364
    A colorectal cancer sample4--see VAR_0361362 A T mis40--------
    VAR_0361374
    A colorectal cancer sample4--see VAR_0361372 T M mis40--------
    VAR_0361384
    A colorectal cancer sample4--see VAR_0361382 S I mis40--------
    VAR_0324254
    Torg-Winchester syndrome (TWS)4--see VAR_0324252 E K mis40--------
    VAR_0324244
    ----see VAR_0324242 D Y mis40--------
    rs711496171,2
    C--41401325(+) GGGGG-/G/GG  
            
    GCGGT
    2 -- int1 us2k12NA CSA 4
    rs719914121,2
    C--41407659(+) AATGC-/GTGT  
            
    GTGTG
    2 -- int10--------
    rs713930831,2
    C,F--41426242(+) CAGGCG/ATGAGC 2 -- int12Minor allele frequency- A:0.50NA 4
    rs2006820911,2
    C--55513891(+) TTTGG-/GC/GG 
            
    GGGGG
    2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for MMP2 (55423612 - 55540603 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP2: --

    Human Gene Mutation Database (HGMD): MMP2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120360   
    OMIM disorders: 259600  
    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
  • Torg-Winchester syndrome (TWS) [MIM:259600]: An autosomal recessive syndrome characterized by severe
    multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse
    face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 20/300 diseases for MMP2 (see all 300):    About MalaCards
    winchester syndrome    multicentric osteolysis nephropathy    multicentric osteolysis of torg    torg winchester syndrome
    klatskin's tumor    focal myositis    granuloma annulare    arthropathy
    lentigo maligna melanoma    microcystic meningioma    fibromatosis, gingival    lymphangioleiomyomatosis
    intestinal neoplasm    cluttering    arthritis    conjunctivochalasis
    corneal ulcer    aortic aneurysm    fibromatosis    lung giant cell carcinoma

    20/21 diseases from the University of Copenhagen DISEASES database for MMP2 (see all 21):
    Vascular disease     Carcinoma     Malignant glioma     Heart disease
    Breast cancer     Melanoma     Lung cancer     Arthritis
    Ovarian cancer     Lung disease     Hepatocellular carcinoma     Prostate cancer
    Periodontal disease     Colorectal cancer     Pancreatic cancer     Keratitis
    Brain disease     Fibrosarcoma     Urinary bladder cancer     Kidney disease

    MMP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for MMP2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 83.8 859 11594775 (5), 9772533 (5), 11903578 (5), 9291433 (5) (see all 99)
    tumors 78.7 1819 16425263 (7), 16581051 (6), 10366463 (6), 12218298 (6) (see all 99)
    cancer 72 578 19360311 (6), 10861469 (5), 8611434 (4), 10971291 (4) (see all 99)
    fibrosarcoma 71 71 8530350 (2), 9716492 (2), 15147870 (2), 18222489 (2) (see all 50)
    glioma 62.8 228 17593815 (7), 11517976 (6), 15743799 (6), 18652821 (6) (see all 82)
    cancer invasiveness 61.4 10 15349101 (1), 11172680 (1), 15492268 (1), 19056927 (1) (see all 6)
    glioblastoma 60.6 72 9219724 (4), 10389763 (4), 9708803 (4), 10895974 (3) (see all 34)
    melanoma 60.3 293 18187184 (10), 10878545 (6), 9875140 (6), 16045689 (6) (see all 99)
    carcinoma squamous cell 59.6 143 16708802 (6), 14990972 (5), 20510080 (4), 19088827 (4) (see all 80)
    liver fibrosis 59.5 36 15482348 (4), 18217401 (3), 9397993 (2), 10498646 (2) (see all 23)

    Genetic Association Database (GAD): MMP2
    Human Genome Epidemiology (HuGE) Navigator: MMP2 (160 documents)

    Export disorders for MMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP2 gene, integrated from 9 sources (see all 3703):
    (articles sorted by number of sources associating them with MMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. (PubMed id 17435175)1, 2, 9 Sariahmetoglu M....Schulz R. (2007)
    2. Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer. (PubMed id 17236757)1, 4, 9 Wu C.Y....Lin J.T. (2007)
    3. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PubMed id 20113256)1, 4, 9 Yi Y.C....Yang S.F. (2010)
    4. Association of metalloproteinase gene polymorphisms w ith systemic sclerosis in the European Caucasian population. (PubMed id 20110530)1, 4, 9 Wipff J....Allanore Y. (2010)
    5. MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (PubMed id 17448043)1, 4, 9 Chen D....Wu Z.F. (2007)
    6. Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression. (PubMed id 17958893)1, 4, 9 Cotignola J....Orlow I. (2007)
    7. Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. (PubMed id 14604886)1, 4, 9 Zhou Y....Lin D. (2004)
    8. Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis. (PubMed id 18155181)1, 4, 9 Gurkan A....Berdeli A. (2008)
    9. Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms). (PubMed id 18802702)1, 4, 9 Barlas I.O....Turkmen E. (2008)
    10. [Study on the association of SNPs of MMP-2 and TIMP-2 genes with the risk of endometriosis and adenomyosis.] (PubMed id 18543216)1, 4, 9 Zhao X....Kang S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4313 HGNC: 7166 AceView: MMP2 Ensembl:ENSG00000087245 euGenes: HUgn4313
    ECgene: MMP2 Kegg: 4313 H-InvDB: MMP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MMP2 gene:
    Search GeneIP for patents involving MMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     adenovirus for overexpression of MMP2
     LSBio Antibodies in human, mouse, rat for MMP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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