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Aliases for MMP2 Gene

Aliases for MMP2 Gene

  • Matrix Metallopeptidase 2 2 3
  • CLG4A 3 4 6
  • Matrix Metalloproteinase-2 3 4
  • EC 3.4.24.24 4 63
  • MMP-2 3 4
  • TBE-1 3 4
  • Mona 3 6
  • Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase) 2
  • Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase) 3
  • Matrix Metalloproteinase-II 3
  • 72 KDa Type IV Collagenase 3
  • Collagenase Type IV-A 3
  • Neutrophil Gelatinase 3
  • 72 KDa Gelatinase 4
  • Gelatinase A 4
  • EC 3.4.24 63
  • MMP-II 3
  • CLG4 3

External Ids for MMP2 Gene

Previous HGNC Symbols for MMP2 Gene

  • CLG4
  • CLG4A

Previous GeneCards Identifiers for MMP2 Gene

  • GC16P045928
  • GC16P055478
  • GC16P055161
  • GC16P055291
  • GC16P054070
  • GC16P041400

Summaries for MMP2 Gene

Entrez Gene Summary for MMP2 Gene

  • This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for MMP2 Gene

MMP2 (Matrix Metallopeptidase 2) is a Protein Coding gene. Diseases associated with MMP2 include multicentric osteolysis, nodulosis, and arthropathy and torg winchester syndrome. Among its related pathways are Proteoglycans in cancer and Pathways in cancer. GO annotations related to this gene include serine-type endopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is MMP19.

UniProtKB/Swiss-Prot for MMP2 Gene

  • Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14

  • PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels

  • Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways

Tocris Summary for MMP2 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP2 Gene

Genomics for MMP2 Gene

Regulatory Elements for MMP2 Gene

Genomic Location for MMP2 Gene

Start:
55,389,700 bp from pter
End:
55,506,691 bp from pter
Size:
116,992 bases
Orientation:
Plus strand

Genomic View for MMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP2 Gene

Proteins for MMP2 Gene

  • Protein details for MMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08253-MMP2_HUMAN
    Recommended name:
    72 kDa type IV collagenase
    Protein Accession:
    P08253
    Secondary Accessions:
    • B2R6U1
    • B4DWH3
    • E9PE45
    • Q9UCJ8

    Protein attributes for MMP2 Gene

    Size:
    660 amino acids
    Molecular mass:
    73882 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.

    Three dimensional structures from OCA and Proteopedia for MMP2 Gene

    Alternative splice isoforms for MMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP2 Gene

Proteomics data for MMP2 Gene at MOPED

Post-translational modifications for MMP2 Gene

  • Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
  • The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.
  • Glycosylation at Asn573 and Asn642
  • Modification sites at PhosphoSitePlus

Domains for MMP2 Gene

Suggested Antigen Peptide Sequences for MMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P08253

UniProtKB/Swiss-Prot:

MMP2_HUMAN :
  • P08253
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 3 fibronectin type-II domains.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP2: view

Function for MMP2 Gene

Molecular function for MMP2 Gene

GENATLAS Biochemistry: matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed in inflammatory bowel diseases
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly- -Ile-Ala-Gly-Gln
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by histatin-3 1/24 (histatin-5).
UniProtKB/Swiss-Prot Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14
UniProtKB/Swiss-Prot Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels
UniProtKB/Swiss-Prot Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways
UniProtKB/Swiss-Prot Induction: Aspirin appears to inhibit expression.

Enzyme Numbers (IUBMB) for MMP2 Gene

LifeMap Function Summary for MMP2 Gene

During embryonic development, MMP2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 21441952
GO:0008237 metallopeptidase activity IDA 24236012
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP2: view
genes like me logo Genes that share phenotypes with MMP2: view

Animal Models for MMP2 Gene

MGI Knock Outs for MMP2:

No data available for Transcription Factor Targeting and HOMER Transcription for MMP2 Gene

Localization for MMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP2 Gene

Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Isoform 2: Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP2 Gene COMPARTMENTS Subcellular localization image for MMP2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytoskeleton 3
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 18492766
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with MMP2: view

Pathways for MMP2 Gene

genes like me logo Genes that share pathways with MMP2: view

Gene Ontology (GO) - Biological Process for MMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001955 blood vessel maturation IEA --
GO:0001957 intramembranous ossification IEA --
GO:0006508 proteolysis IDA 15863497
genes like me logo Genes that share ontologies with MMP2: view

Compounds for MMP2 Gene

(15) ApexBio Compounds for MMP2 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2. [704888-90-4]
ARP 101 Selective inhibitor of MMP-2. [849773-63-3]
Batimastat (BB-94) potent and synthetic inhibitor of a broad spectrum of MMPs [130370-60-4]
CL 82198 hydrochloride Selective inhibitor of MMP-13. [307002-71-7]
CP 471474 Broad spectrum MMP inhibitor. [210755-45-6]
CTS-1027 potent small molecule inhibitor of MMPs. [193022-04-7]
GM 6001 Broad-spectrum MMP inhibitor. [142880-36-2]
Marimastat Broad spectrum inhibitor of MMPs. [154039-60-8]
NSC 405020 novel small molecule inhibitor of MT1-MMP [7497-7-6]
ONO 4817 Broad spectrum MMP inhibitor. [223472-31-9]
PD 166793 Broad spectrum MMP inhibitor. [199850-67-4]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor. [190648-49-8]
UK 356618 Potent and selective inhibitor of MMP-3. [230961-08-7]
UK 370106 Highly selective MMP-3 and MMP-12 inhibitor. [230961-21-4]
WAY 170523 Potent and selective inhibitor of MMP-13. [307002-73-9]

(5) Tocris Compounds for MMP2 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for MMP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Captopril
  • Captoprilum [INN-Latin]
62571-86-2 target inhibitor
Marimastat
154039-60-8 target inhibitor
SC-74020
  • SC 74020
target

(1) IUPHAR Ligand for MMP2 Gene

Ligand Type Action Affinity Pubmed IDs
ARP100 Inhibitor Inhibition

(136) Novoseek inferred chemical compound relationships for MMP2 Gene

Compound -log(P) Hits PubMed IDs
matrigel 88.6 95
(4-aminophenyl)mercuric acetate 80 12
batimastat 78.7 7
ilomastat 78.4 12
vegf 75.7 303
genes like me logo Genes that share compounds with MMP2: view

Transcripts for MMP2 Gene

Unigene Clusters for MMP2 Gene

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP2 Gene

No ASD Table

Relevant External Links for MMP2 Gene

GeneLoc Exon Structure for
MMP2
ECgene alternative splicing isoforms for
MMP2

Expression for MMP2 Gene

mRNA expression in normal human tissues for MMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMP2 Gene

SOURCE GeneReport for Unigene cluster for MMP2 Gene Hs.513617

mRNA Expression by UniProt/SwissProt for MMP2 Gene

P08253-MMP2_HUMAN
Tissue specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
genes like me logo Genes that share expressions with MMP2: view

No data available for mRNA differential expression in normal tissues for MMP2 Gene

Orthologs for MMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP2 35
  • 99.24 (n)
  • 99.54 (a)
MMP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP2 35
  • 90.69 (n)
  • 94.99 (a)
MMP2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP2 35
  • 91.48 (n)
  • 96.72 (a)
MMP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp2 35
  • 89.44 (n)
  • 95.91 (a)
Mmp2 16
Mmp2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp2 35
  • 88.43 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves MMP2 35
  • 75.53 (n)
  • 83.93 (a)
MMP2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Mmp2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp2 35
  • 73.54 (n)
  • 81.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12093 35
zebrafish
(Danio rerio)
Actinopterygii mmp2 35
  • 72.19 (n)
  • 75.16 (a)
mmp2 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 22 (a)
ManyToMany
zmp-1 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1986 36
  • 49 (a)
OneToOne
Species with no ortholog for MMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP2 Gene

ENSEMBL:
Gene Tree for MMP2 (if available)
TreeFam:
Gene Tree for MMP2 (if available)

Paralogs for MMP2 Gene

Paralogs for MMP2 Gene

Selected SIMAP similar genes for MMP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MMP2: view

Variants for MMP2 Gene

Sequence variations from dbSNP and Humsavar for MMP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7201 -- 55,505,702(+) GAGAT(A/C)CTTTG utr-variant-3-prime
rs14070 -- 55,502,815(+) GGCTT(C/T)CCCAA reference, synonymous-codon
rs15142 -- 55,506,131(+) CTGGA(A/T)GGAGG utr-variant-3-prime
rs171497 -- 55,497,898(+) AGACT(A/G)TTGTC intron-variant
rs171498 -- 55,496,850(+) GGGTG(G/T)GTTTG intron-variant

Relevant External Links for MMP2 Gene

HapMap Linkage Disequilibrium report
MMP2
Human Gene Mutation Database (HGMD)
MMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP2 Gene

Disorders for MMP2 Gene

(1) OMIM Diseases for MMP2 Gene (120360)

UniProtKB/Swiss-Prot

MMP2_HUMAN
  • Multicentric osteolysis, nodulosis, and arthropathy (MONA) [MIM:259600]: An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. {ECO:0000269 PubMed:11431697, ECO:0000269 PubMed:15691365, ECO:0000269 PubMed:16542393}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for MMP2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 83.8 272
tumors 78.7 354
cancer 72 196
fibrosarcoma 71 59
glioma 62.8 171

Relevant External Links for MMP2

Genetic Association Database (GAD)
MMP2
Human Genome Epidemiology (HuGE) Navigator
MMP2
genes like me logo Genes that share disorders with MMP2: view

Publications for MMP2 Gene

  1. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. (PMID: 11431697) Martignetti J.A. … Desnick R.J. (Nat. Genet. 2001) 3 4 23
  2. Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor. (PMID: 12147339) Feng Y. … Stallings W.C. (Biochim. Biophys. Acta 2002) 3 4 23
  3. Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung cancer. (PMID: 12438229) Yu C. … Lin D. (Cancer Res. 2002) 3 23 48
  4. Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. (PMID: 12657623) Harendza S. … Stahl R.A. (J. Biol. Chem. 2003) 3 23 48
  5. A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. (PMID: 12873995) Miao X. … Lin D. (Cancer Res. 2003) 3 23 48

Products for MMP2 Gene

  • Addgene plasmids for MMP2

Sources for MMP2 Gene

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