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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP2 Gene

protein-coding   GIFtS: 74
GCID: GC16P055424

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase,...

(Previous names: matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase,...)
(Previous symbols: CLG4, CLG4A)
 Explore 338 diseases affiliated with
MMP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MMP2    

Aliases
for MMP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV
Collagenase)1 2
     MONA2 5
CLG4A1 2 3 5     Matrix Metalloproteinase 2 (Gelatinase A, 72kD Gelatinase, 72kD Type IV
Collagenase)1
TBE-11 2 3     Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV
Collagenase)1
CLG41 2     72 KDa Type IV Collagenase2
Gelatinase A2 3     MMP-II2
Matrix Metalloproteinase-22 3     Collagenase Type IV-A2
72 KDa Gelatinase2 3     Matrix Metalloproteinase-II2
MMP-22 3     Neutrophil Gelatinase2
EC 3.4.24.243 8     EC 3.4.248

External Ids:    HGNC: 71661   Entrez Gene: 43132   Ensembl: ENSG000000872457   OMIM: 1203605   UniProtKB: P082533   

Export aliases for MMP2 gene to outside databases

Previous GC identifers: GC16P045928 GC16P055478 GC16P055161 GC16P055291 GC16P054070 GC16P041400


Summaries
for MMP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MMP2:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major
structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of
vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome
and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature,
angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading
extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP
promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death
pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro
Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and
inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood
vessels
Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing
mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional
pathways

summary for MMP2:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP2


Genomic Views
for MMP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP2 gene promoter:
         SRF   Sp1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13-q21

MMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055424:  view genomic region     (about GC identifiers)

Start:
 55,423,612 bp from pter      End:
 55,540,603 bp from pter
Size:
 116,992 bases      Orientation:
 plus strand

Proteins
for MMP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 (See protein sequence)
Recommended Name: 72 kDa type IV collagenase precursor  
Size: 660 amino acids; 73882 Da
Cofactor: Binds 4 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Subunit: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the
interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX
domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B
Subcellular location: Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus.
Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found
in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
Subcellular location: Isoform 2: Cytoplasm. Mitochondrion
6/11 PDB 3D structures from and Proteopedia for MMP2 (see all 11):
1CK7 (3D)        1CXW (3D)        1EAK (3D)        1GEN (3D)        1GXD (3D)        1HOV (3D)    
Secondary accessions: B2R6U1 B4DWH3 E9PE45 Q9UCJ8
Alternative splicing: 3 isoforms:  P08253-1   P08253-2   P08253-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MMP2: NX_P08253

Post-translational modifications:

  • Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro1
  • The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces
    • the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta31
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08253

    • 4/26 DME Specific Peptides for MMP2 (P08253) (see all 26)
     DGYPFDG  YNFFPRK  GEADIMI  GLLAHAF 

    MMP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121363.1  NP_004521.1  

    ENSEMBL proteins: 
     ENSP00000461421   ENSP00000457949   ENSP00000219070   ENSP00000456096   ENSP00000444143  
     ENSP00000394237   ENSP00000456518   ENSP00000461915  
    Reactome Protein details: P08253
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP2 (MMP-2)
    Enzo Life Sciences proteins for MMP2
    OriGene Purified Protein: MMP2
    OriGene Protein Over-expression Lysate: MMP2
    OriGene Custom Protein Services for MMP2 
    GenScript Custom Purified and Recombinant Proteins Services for MMP2
    Novus Biologicals MMP2 Proteins
    Novus Biologicals MMP2 Lysates
    Sino Biological Recombinant Protein for MMP2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MMP2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005581collagen ----
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--


    MMP2 for ontologies           About GeneDecksing



    MMP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP2
    R&D Systems Antibodies for MMP2 (MMP-2)
    Cell Signaling Technology (CST) Antibodies for MMP2 
    OriGene Antibodies (see all 7): MMP2
    OriGene Custom Antibody Services for MMP2 
    GenScript Custom Superior Antibodies Services for MMP2
    Novus Biologicals MMP2 Antibodies
    Abcam antibodies for MMP2 
    Uscn Antibodies for MMP2
    ThermoFisher Antibody for MMP2

    Assay Products for MMP2: 
    EMD Millipore Kits and Assays for the Analysis of MMP2
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MMP2 (MMP-2)         (see all)
    GenScript MMP2-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for MMP2
    Uscn ELISAs and CLIAs for MMP2

    Protein Domains /
    Families
    for MMP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MMP2 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A_matrixin
     IPR000585 Hemopexin/matrixin
     IPR018486 Hemopexin/matrixin_CS

    Graphical View of Domain Structure for InterPro Entry P08253

    ProtoNet protein and cluster: P08253

    3 Blocks protein families:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 3 fibronectin type-II domains
    Similarity: Contains 4 hemopexin-like domains


    Function
    for MMP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature,
    angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading
    extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP
    promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death
    pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro
    Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and
    inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood
    vessels
    Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing
    mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional
    pathways
    Catalytic activity: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence
    Pro-Gln-Gly- -Ile-Ala-Gly-Gln
    Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5)
    Induction: Aspirin appears to inhibit expression

         Genatlas biochemistry entry for MMP2:
    matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and
    intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed in
    inflammatory bowel diseases

    Enzyme Numbers (IUBMB): EC 3.4.24.241 2 EC 3.4.242

         Summary:  
    During embryonic development, MMP2 as signaling molecule is secreted from the following cells: Septum Transversum Mesenchyme Cells in Septum Transversum It affects the following cells: Hepatoblasts in Liver Bud

    miRNA
    Products:            		miRTarBase miRNAs that target MMP2:
    hsa-mir-451 (MIRT005742), hsa-mir-29b (MIRT005570)

    OriGene 3'-UTR Clone (see all 2): MMP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP2
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP2 (see all 27):
    hsa-miR-3164 hsa-miR-2110 hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-519a hsa-miR-511 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: MMP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP2 (see all 7)
    OriGene shRNA RFP: MMP2
    OriGene siRNA: MMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MMP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MMP2 (NM_004530)
    Sino Biological Human cDNA Clone for MMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MMP2
    LifeMap BioReagents: cell lines associated with MMP2: PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    MMP2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MMP2:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Mmp2tm1Ito for MMP2
         12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp2):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  normal  respiratory system  skeleton 
     tumorigenesis  vision/eye 

    MMP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MMP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Activation of Matrix Metalloproteinases0.40
    		Degradation of collagen0.79
    2Cell adhesion_ECM remodeling
    		Cell adhesion ECM remodeling1.00
    		Metalloproteases in connective tissue degradation0.31
    		Cell adhesion_ECM remodeling1.00
    3Transcription_P53 signaling pathway
    		Transcription_P53 signaling pathway1.00
    		Transcription P53 signaling pathway0.98
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Degradation of collagen
    		Degradation of collagen1.00
    		Extracellular matrix organization0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for MMP2
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation
    Transcription P53 signaling pathway

    1 R&D Systems Pathway for MMP2
        A-beta Uptake & Degradation

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP2 (see all 6)
        Glioma Invasiveness
    Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    2 Cell Signaling Technology (CST) Pathways for MMP2
        Angiogenesis
    Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for MMP2
        Transcription Androgen Receptor nuclear signaling
    Transcription P53 signaling pathway
    Development EGFR signaling pathway
    Cell adhesion ECM remodeling

    5/14 BioSystems Pathways for MMP2 (see all 14) 
        Matrix Metalloproteinases
    AGE/RAGE pathway
    IL-3 Signaling Pathway
    amb2 Integrin signaling
    LPA receptor mediated events

    5/9        Reactome Pathways for MMP2 (see all 9)
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Degradation of collagen
    Degradation of collagen
    Activation of Matrix Metalloproteinases
    Extracellular matrix organization


    4         Kegg Pathways  (Kegg details for MMP2):
        Leukocyte transendothelial migration
    GnRH signaling pathway
    Pathways in cancer
    Bladder cancer


    MMP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for MMP2 (P082531, 3 ENSP000002190704) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL7P800983, ENSP000002003074I2D: score=3 STRING: ENSP00000200307
    COL1A1P024523, ENSP000002259644I2D: score=2 STRING: ENSP00000225964
    LCN2P801883, ENSP000002774804I2D: score=2 STRING: ENSP00000277480
    LGALS3P179313, ENSP000002543014I2D: score=2 STRING: ENSP00000254301
    THBS2P354423, ENSP000003557514I2D: score=2 STRING: ENSP00000355751
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001955blood vessel maturation IEA--
    GO:0001957intramembranous ossification IEA--
    GO:0006508proteolysis IEA--


    MMP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MMP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMP2 for compounds           About GeneDecksing

    EMD Millipore small molecules for MMP2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MMP2

    Compounds for MMP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Inhibitor of MMP-2--
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for MMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2targetinhibitor19057128 10328230 15993560 20184869 12381651 17308006
    Marimastat-- 154039-60-8targetinhibitor12527923 15748894 11790786 15056115 11752352 10460642
    SC-74020SC 74020 (see all 2)--target--17139284 17016423

    10/136 Novoseek chemical compound relationships for MMP2 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 88.6 110 9413149 (4), 8292337 (3), 10491398 (3), 11431735 (2) (see all 82)
    (4-aminophenyl)mercuric acetate 80 23 1480033 (3), 2269296 (2), 9628251 (1), 7896811 (1) (see all 9)
    batimastat 78.7 10 9816289 (1), 11598905 (1), 10585576 (1), 11276015 (1) (see all 7)
    ilomastat 78.4 18 17512742 (2), 18665992 (2), 18465841 (1), 20299089 (1) (see all 10)
    vegf 75.7 623 16584583 (8), 16875630 (6), 16124061 (6), 16962110 (6) (see all 99)
    marimastat 67 4 12405288 (1), 12527923 (1), 19735728 (1)
    prinomastat 64.5 9 11060800 (1), 16483784 (1), 20215503 (1), 10415735 (1) (see all 5)
    cgs-27023a 63 2 15080939 (1), 11948136 (1)
    col 3 61 10 12850461 (3), 16205320 (2), 11469893 (1), 11320090 (1) (see all 7)
    hydroxamate 59.5 17 12147339 (2), 12475252 (1), 15781326 (1), 9548812 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about MMP2 

    Transcripts
    for MMP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section
    REFSEQ mRNAs for MMP2 gene (2 alternative transcripts): 
    NM_001127891.1  NM_004530.4  

    Unigene Cluster for MMP2:

    Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
    Hs.513617  [show with all ESTs]
    Unigene Representative Sequence: NM_004530
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570308 ENST00000568715 ENST00000219070(uc002ehz.4 uc010vhd.2 uc010ccc.3)
    ENST00000564864 ENST00000543485 ENST00000437642 ENST00000570283 ENST00000566564


    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP2 (see all 27):
    hsa-miR-3164 hsa-miR-2110 hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-519a hsa-miR-511 hsa-miR-93
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP2 (see all 7)
    OriGene shRNA RFP: MMP2
    OriGene siRNA: MMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MMP2 (NM_004530)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2 
    Primer
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    Additional cDNA sequence: 

    AK057680.1 AK301536.1 AK310314.1 AK312711.1 AL832088.1 BC002576.2 DQ385623.1 J03210.1 
    X58968.1 

    24/35 DOTS entries (see all 35):

    DT.95130460  DT.100652571  DT.75124861  DT.92058175  DT.100762889  DT.101985660  DT.92462977  DT.100637823 
    DT.120668918  DT.120668959  DT.120668954  DT.91892990  DT.95336528  DT.100646179  DT.120668946  DT.120669002 
    DT.95091235  DT.120668909  DT.120668975  DT.92462967  DT.92462969  DT.92462976  DT.100722515  DT.120668915 

    24/601 AceView cDNA sequences (see all 601):

    AA371152 BU158122 BX446048 CO245644 X58968 CA446916 BQ675400 BM988343 
    BM725839 AA369008 AI752103 BI832444 BP345957 CA411796 CO397029 BU145691 
    BQ030384 AI754338 CF125592 BE382786 CN480197 BM727669 CO249164 BQ669774 

    GeneLoc Exon Structure


    Expression
    for MMP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAATGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MMP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/35 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 35) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See MMP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP2

    SOURCE GeneReport for Unigene cluster: Hs.513617

    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Tissue specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas,
    breast and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including MMP2 (see all 14): 
              Osteogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MMP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP2 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MMP21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, more 76.02(n)
    84.95(a)    		   386583  NM_204420.2  NP_989751.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MMP26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 LGc(2266047-2308547)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Mmp22 matrix metalloproteinase 2 76.61(n)    AY037943.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mmp22 matrix metalloproteinase 2 77.22(n)   337179  AY324195.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea H36L18.16
    		 Protein H36L18.1
    		 23(a)
    		 possible ortholog
    		 X(12647047-12651417)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G599706
    AT4G166406
    (see all 5)    		 matrix metalloprotease domain-containing protein
    (see all 5)    		 27(a)
    26(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 1(22073534-22074876)
    4(9367248-9368775)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 matrixin family protein
    metalloendoproteinase 1 precursor, putative, expre...
    (see all 4)    		 9(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 10(21890877-21896676)
    2(30974996-30977090)


    ENSEMBL Gene Tree for MMP2 (if available)
    TreeFam Gene Tree for MMP2 (if available) 

    Paralogs
    for MMP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP2 gene
    MMP132  MMP202  MMP82  MMP142  MMP92  MMP162  MMP252  MMP242  
    MMP152  MMP112  MMP32  MMP272  MMP172  MMP102  MMP12  
    13 SIMAP similar genes for MMP2 using alignment to 5 protein entries:     MMP2_HUMAN (see all proteins):
    MMP15    MMP7    MMP1    MMP26    MMP10    MMP3
    MMP9    MMP13    MMP8    MMP17    mmp20    MMP14
    MMP11

    MMP2 for paralogs           About GeneDecksing



    Genomic Variants
    for MMP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/675 NCBI SNPs in MMP2 are shown (see all 675)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178598131,2
    		C,--41398805(+) GGTTTG/ATCACT 1 -- us2k11Minor allele frequency- A:0.01NS 176
    rs178598151,2
    		C,--41399022(+) TTGCTC/TCTGAT 1 -- us2k11Minor allele frequency- T:0.01NS 178
    rs178598161,2
    		C,F,--41399090(+) TGCCCC/GCTTCC 1 -- us2k1 trp37Minor allele frequency- G:0.05NS MN WA 704
    rs740190951,2
    		C,--41399143(+) CTGTGC/TCCCAC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs178598171,2
    		C,F,--41399151(+) CACCTT/CTTTCA 1 -- us2k17Minor allele frequency- C:0.02NS MN WA 702
    rs178598191,2
    		C,F,--41399436(+) CAGAGA/TCGGTT 1 -- us2k18Minor allele frequency- T:0.02NS WA 934
    rs178598201,2
    		C,--41399438(+) GAGACG/AGTTGT 1 -- us2k12Minor allele frequency- A:0.01NS WA 284
    rs178598241,2
    		C,--41399732(+) TCTTCA/GCTGCA 1 -- us2k11Minor allele frequency- G:0.01NS 174
    rs728107811,2
    		C,--41399777(+) TCTTAT/GTAAAC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs178598261,2
    		C,--41400000(+) CATTTG/CCAGAA 1 -- us2k13Minor allele frequency- C:0.02NS WA NA 418

    HapMap Linkage Disequilibrium report for MMP2 (55423612 - 55540603 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MMP2
         1 Indel: 60208
    Human Gene Mutation Database (HGMD): MMP2

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    Disorders / Diseases
    for MMP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MMP2 for disorders           About GeneDecksing

    OMIM gene information: 120360   
    OMIM disorders: 259600  
    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
  • Defects in MMP2 are the cause of Torg-Winchester syndrome (TWS) [MIM:259600]; also known as multicentric
    • osteolysis nodulosis and arthropathy (MONA). TWS is an autosomal recessive osteolysis syndrome. It is severe with
    generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been
    associated with a number of additional features including coarse face, corneal opacities, patches of thickened,
    hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have
    occasionally been observed in other osteolysis syndromes

    20/338 diseases for MMP2 (see all 338):    About MalaCards
    winchester syndrome    osteolysis    torg winchester syndrome    arthropathy
    emery-dreifuss muscular dystrophy    arthritis    estrogen-receptor positive breast cancer    spinal cord injury
    toxic epidermal necrolysis    encephalomyelitis    lentigo maligna melanoma    open-angle glaucoma
    otitis media    hepatocellular carcinoma (fibrolamellar variant)    stevens-johnson syndrome    aortic aneurysm
    middle ear cholesteatoma    multicentric osteolysis nephropathy    chronic venous leg ulcers    age related macular degeneration

    20 diseases from the University of Copenhagen DISEASES database for MMP2:
    Vascular disease     Carcinoma     Malignant glioma     Heart disease
    Breast cancer     Lung cancer     Arthritis     Melanoma
    Eye disease     Ovarian cancer     Periodontal disease     Hepatocellular carcinoma
    Lung disease     Prostate cancer     Colorectal cancer     Brain disease
    Pancreatic cancer     Fibrosarcoma     Urinary bladder cancer     Endometriosis

    10/97 Novoseek disease relationships for MMP2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 83.8 859 11594775 (5), 9772533 (5), 11903578 (5), 9291433 (5) (see all 99)
    tumors 78.7 1819 16425263 (7), 16581051 (6), 10366463 (6), 12218298 (6) (see all 99)
    cancer 72 578 19360311 (6), 10861469 (5), 8611434 (4), 10971291 (4) (see all 99)
    fibrosarcoma 71 71 8530350 (2), 9716492 (2), 15147870 (2), 18222489 (2) (see all 50)
    glioma 62.8 228 17593815 (7), 11517976 (6), 15743799 (6), 18652821 (6) (see all 82)
    cancer invasiveness 61.4 10 15349101 (1), 11172680 (1), 15492268 (1), 19056927 (1) (see all 6)
    glioblastoma 60.6 72 9219724 (4), 10389763 (4), 9708803 (4), 10895974 (3) (see all 34)
    melanoma 60.3 293 18187184 (10), 10878545 (6), 9875140 (6), 16045689 (6) (see all 99)
    carcinoma squamous cell 59.6 143 16708802 (6), 14990972 (5), 20510080 (4), 19088827 (4) (see all 80)
    liver fibrosis 59.5 36 15482348 (4), 18217401 (3), 9397993 (2), 10498646 (2) (see all 23)

    Genetic Association Database (GAD): MMP2
    Human Genome Epidemiology (HuGE) Navigator: MMP2 (160 documents)

    Export disorders for MMP2 gene to outside databases

    Publications
    for MMP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP2 gene, integrated from 9 sources (see all 3626):
    (articles sorted by number of sources associating them with MMP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. (PubMed id 17435175)1, 2, 9 Sariahmetoglu M....Schulz R. (2007)
    2. Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. (PubMed id 14604886)1, 4, 9 Zhou Y....Lin D. (2004)
    3. [Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2) and MMP-9 genes with risk of gastric cancer in a Chinese population.] (PubMed id 15522165)1, 4, 9 Zhang X.M....Lin D.X. (2004)
    4. The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. (PubMed id 16275157)1, 4, 9 O-Charoenrat P. and Khantapura P. (2006)
    5. Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. (PubMed id 15731163)1, 4, 9 Zhou Y....Lin D. (2005)
    6. Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (PubMed id 16082623)1, 4, 9 Eriksson P....Powell J.T. (2005)
    7. A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer. (PubMed id 15485653)1, 4, 9 Xu E....Xia X. (2004)
    8. A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. (PubMed id 12873995)1, 4, 9 Miao X....Lin D. (2003)
    9. Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor. (PubMed id 12147339)1, 2, 9 Feng Y....Stallings W.C. (2002)
    10. Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. (PubMed id 16356191)1, 4, 9 Rodriguez-Lopez J....Gonzalez A. (2006)

    External Searches for MMP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MMP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4313 HGNC: 7166 AceView: MMP2 Ensembl:ENSG00000087245 euGenes: HUgn4313
    ECgene: MMP2 Kegg: 4313 H-InvDB: MMP2

    Other Databases showing MMP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MMP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp2/

    Intellectual Property
    for MMP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MMP2 gene:
    Search GeneIP for patents involving MMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics
    About This Section

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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MMP2 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with MMP2: PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem Z11, Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2
     SwitchGear 3'UTR luciferase reporter plasmids for MMP2
     SwitchGear Promoter luciferase reporter plasmids for MMP2
     ThermoFisher Antibody for MMP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2
           
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