MMP2 Gene
protein-coding GIFtS : 74
GCID: GC16 P055424
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase,... (Previous names: matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase,... ) (Previous symbols: CLG4, CLG4A )
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Aliasesfor MMP2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IVCollagenase) 1 2 MONA2 5 CLG4A1 2 3 5 Matrix Metalloproteinase 2 (Gelatinase A, 72kD Gelatinase, 72kD Type IVCollagenase)1 TBE-11 2 3 Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IVCollagenase)1 CLG41 2 72 KDa Type IV Collagenase2 Gelatinase A2 3 MMP-II2 Matrix Metalloproteinase-22 3 Collagenase Type IV-A2 72 KDa Gelatinase2 3 Matrix Metalloproteinase-II2 MMP-22 3 Neutrophil Gelatinase2 EC 3.4.24.243 8 EC 3.4.248
Export aliases for MMP2 gene to outside databases Previous GC identifers: GC16P045928 GC16P055478 GC16P055161 GC16P055291 GC16P054070 GC16P041400
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Summariesfor MMP2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MMP2 : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 Function : Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature,angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro Function : PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties andinhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels Function : Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducingmitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways summary
for MMP2 : Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependentendopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading awide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have beenidentified in humans, which can be organized into six groups based on domain organization and substratepreference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cellproliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPshas been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumorto secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of thebasement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselvesor by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMPexpression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 allhave elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs resultin inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion. Gene Wiki entry for MMP2
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Genomic Viewsfor MMP2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MMP2 gene promoter: SRF Sp1 SRF (504 AA) Other transcription factors Search SABiosciences Chromatin IP Primers for MMP2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MMP2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q13-q21 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13-q21 MMP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P055424: view genomic region
(about GC identifiers )
Start:
55,423,612 bp from pter
End:
55,540,603 bp from pter
Size:
116,992 bases
Orientation:
plus strand
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Proteinsfor MMP2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 (See
protein sequence )Recommended Name: 72 kDa type IV collagenase precursor Size : 660 amino acids; 73882 Da
Cofactor : Binds 4 calcium ions per subunit
Cofactor : Binds 2 zinc ions per subunit
Subunit : Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; theinteraction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B
Subcellular location : Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus.Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
Subcellular location : Isoform 2: Cytoplasm. Mitochondrion
6/11 PDB 3D structures from and Proteopedia for MMP2 (see all 11 ):1CK7 (3D)
  1CXW (3D)
  1EAK (3D)
  1GEN (3D)
  1GXD (3D)
  1HOV (3D)
 
Secondary accessions : B2R6U1 B4DWH3 E9PE45 Q9UCJ8Alternative splicing : 3 isoforms : P08253-1 P08253-2 P08253-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MMP2: NX_P08253 Post-translational modifications:
Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro1
The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta31
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08253 4/26 DME Specific Peptides for MMP2 (P08253 ) (see all 26 )MMP2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001121363.1 NP_004521.1 ENSEMBL proteins: ENSP00000461421 ENSP00000457949 ENSP00000219070 ENSP00000456096 ENSP00000444143 ENSP00000394237 ENSP00000456518 ENSP00000461915 Reactome Protein details: P08253 Human Recombinant Protein Products: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
MMP2 for ontologies About GeneDecksing MMP2 Antibody Products: Assay Products for MMP2:
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Protein
Domains / Familiesfor MMP2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MMP2 for domains About GeneDecksing 5/11 InterPro domains/families (see all 11 ):
Graphical View of Domain Structure for InterPro Entry P08253 ProtoNet protein and cluster: P08253
3 Blocks protein families : IPB000562 Type II fibronectin collagen-binding domain IPB000585 Hemopexin repeat IPB001818 Matrixin UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Similarity : Belongs to the peptidase M10A familySimilarity : Contains 3 fibronectin type-II domainsSimilarity : Contains 4 hemopexin-like domains
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Functionfor MMP2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 Function : Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature,angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro Function : PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties andinhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels Function : Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducingmitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways Catalytic activity : Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequencePro-Gln-Gly- -Ile-Ala-Gly-Gln Enzyme regulation : Inhibited by histatin-3 1/24 (histatin-5)Induction : Aspirin appears to inhibit expression
Genatlas biochemistry entry for MMP2 : matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed in inflammatory bowel diseases Enzyme Numbers (IUBMB): EC 3.4.24.24 1 2 EC 3.4.24 2 Summary: During embryonic development, MMP2 as signaling molecule is secreted from the following cells: Septum Transversum Mesenchyme Cells in Septum Transversum It affects the following cells: Hepatoblasts in Liver Bud Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MMP2 (NM_004530 ) Sino Biological Human cDNA Clone for MMP2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
MMP2 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for MMP2 :Animal Models: Mouse knock-out Mmp2 tm1Ito for MMP2 12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mmp2) :
MMP2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor MMP2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/35 super-pathways (see all 35 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Degradation of the extracellular matrix 2 Cell adhesion_ECM remodeling 3 Transcription_P53 signaling pathway 4 Transcription_Androgen Receptor nuclear signaling 5 Degradation of collagen
Pathway sources See GeneCards unified pathways Show all pathways 4 EMD Millipore Pathways for MMP2 1 R&D Systems Pathway for MMP2 5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP2 (see all 6 )2
Cell Signaling Technology (CST) Pathways for MMP2 4 GeneGo (Thomson Reuters) Pathways for MMP2 5/14 BioSystems Pathways for MMP2 (see all 14 ) 5/9
Reactome Pathways for MMP2 (see all 9 )4
Kegg Pathways (Kegg details for MMP2) :
MMP2 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/85 Interacting proteins for MMP2 (P08253 1 , 3 ENSP00000219070 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 85 )About this table Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13 ): About this table
MMP2 for ontologies About GeneDecksing
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Drugs & Compoundsfor MMP2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MMP2 for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for MMP2
Compounds for MMP2 available from Tocris Bioscience About this table Compound Action
CAS
# CP 471474 Broad spectrum MMP inhibitor [210755-45-6] ARP 100 Selective inhibitor of MMP-2 [704888-90-4] ARP 101 Inhibitor of MMP-2 -- Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
1 HMDB Compound for MMP2 About this table 3 DrugBank Compounds for MMP2 About this table 10/136 Novoseek chemical compound relationships for MMP2 gene (see all 136 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel
88.6
110
9413149 (4), 8292337 (3), 10491398 (3), 11431735 (2) (see all 82 )
(4-aminophenyl)mercuric acetate
80
23
1480033 (3), 2269296 (2), 9628251 (1), 7896811 (1) (see all 9 )
batimastat
78.7
10
9816289 (1), 11598905 (1), 10585576 (1), 11276015 (1) (see all 7 )
ilomastat
78.4
18
17512742 (2), 18665992 (2), 18465841 (1), 20299089 (1) (see all 10 )
vegf
75.7
623
16584583 (8), 16875630 (6), 16124061 (6), 16962110 (6) (see all 99 )
marimastat
67
4
12405288 (1), 12527923 (1), 19735728 (1)
prinomastat
64.5
9
11060800 (1), 16483784 (1), 20215503 (1), 10415735 (1) (see all 5 )
cgs-27023a
63
2
15080939 (1), 11948136 (1)
col 3
61
10
12850461 (3), 16205320 (2), 11469893 (1), 11320090 (1) (see all 7 )
hydroxamate
59.5
17
12147339 (2), 12475252 (1), 15781326 (1), 9548812 (1) (see all 8 )
Search CenterWatch for drugs/clinical trials and news about MMP2
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Transcriptsfor MMP2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MMP2 gene (2 alternative transcripts): NM_001127891.1 NM_004530.4 Unigene Cluster for MMP2:
Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Hs.513617 [show with all ESTs ] Unigene Representative Sequence: NM_004530 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000570308 ENST00000568715 ENST00000219070 (uc002ehz.4 uc010vhd.2 uc010ccc.3 )ENST00000564864 ENST00000543485 ENST00000437642 ENST00000570283 ENST00000566564 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MMP2 (NM_004530 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP2
Additional cDNA sequence: AK057680.1 AK301536.1 AK310314.1 AK312711.1 AL832088.1 BC002576.2 DQ385623.1 J03210.1 X58968.1
24/35 DOTS entries (see all 35 ): DT.95130460 DT.100652571
DT.75124861 DT.92058175 DT.100762889 DT.101985660 DT.92462977 DT.100637823 DT.120668918 DT.120668959 DT.120668954 DT.91892990 DT.95336528 DT.100646179 DT.120668946 DT.120669002 DT.95091235 DT.120668909 DT.120668975 DT.92462967 DT.92462969 DT.92462976 DT.100722515 DT.120668915 24/601 AceView cDNA sequences (see all 601 ):
AA371152 BU158122 BX446048 CO245644 X58968 CA446916 BQ675400 BM988343 BM725839 AA369008 AI752103 BI832444 BP345957 CA411796 CO397029 BU145691 BQ030384 AI754338 CF125592 BE382786 CN480197 BM727669 CO249164 BQ669774 GeneLoc Exon Structure
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Expression for MMP2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MMP2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGAAATGTCA
About this image MMP2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MMP2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MMP2 SOURCE GeneReport for Unigene cluster: Hs.513617 UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 Tissue specificity : Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas,breast and prostate SABiosciences Expression via Pathway-Focused PCR Arrays including MMP2 (see all 14 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMP2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MMP2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMP2 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2
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Orthologsfor MMP2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for MMP2 gene from 7/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for MMP2 (if available)TreeFam Gene Tree for MMP2 (if available)
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Paralogsfor MMP2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MMP2 gene MMP13 2 MMP20 2 MMP8 2 MMP14 2 MMP9 2 MMP16 2 MMP25 2 MMP24 2 MMP15 2 MMP11 2 MMP3 2 MMP27 2 MMP17 2 MMP10 2 MMP1 2 13 SIMAP similar genes for MMP2 using alignment to 5 protein entries: MMP2_HUMAN (see all proteins ):MMP15 MMP7 MMP1 MMP26 MMP10 MMP3 MMP9 MMP13 MMP8 MMP17 mmp20 MMP14 MMP11
MMP2 for paralogs About GeneDecksing
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Genomic Variantsfor MMP2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MMP2 (55423612 - 55540603 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MMP2 1 Indel : 60208 Human Gene Mutation Database (HGMD) : MMP2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMP2
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Disorders
/ Diseasesfor MMP2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MMP2 for disorders About GeneDecksing OMIM gene information: 120360 OMIM disorders : 259600 UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
Defects in MMP2 are the cause of Torg-Winchester syndrome (TWS) [MIM:259600]; also known as multicentric osteolysis nodulosis and arthropathy (MONA). TWS is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes 20/338 diseases for MMP2 (see all 338 ): About MalaCards winchester syndrome osteolysis torg winchester syndrome arthropathy emery-dreifuss muscular dystrophy arthritis estrogen-receptor positive breast cancer spinal cord injury toxic epidermal necrolysis encephalomyelitis lentigo maligna melanoma open-angle glaucoma otitis media hepatocellular carcinoma (fibrolamellar variant) stevens-johnson syndrome aortic aneurysm middle ear cholesteatoma multicentric osteolysis nephropathy chronic venous leg ulcers age related macular degeneration 20 diseases from the University of Copenhagen DISEASES database for MMP2 :Vascular disease Carcinoma Malignant glioma Heart disease Breast cancer Lung cancer Arthritis Melanoma Eye disease Ovarian cancer Periodontal disease Hepatocellular carcinoma Lung disease Prostate cancer Colorectal cancer Brain disease Pancreatic cancer Fibrosarcoma Urinary bladder cancer Endometriosis 10/97 Novoseek disease relationships for MMP2 gene (see all 97 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis
83.8
859
11594775 (5), 9772533 (5), 11903578 (5), 9291433 (5) (see all 99 )
tumors
78.7
1819
16425263 (7), 16581051 (6), 10366463 (6), 12218298 (6) (see all 99 )
cancer
72
578
19360311 (6), 10861469 (5), 8611434 (4), 10971291 (4) (see all 99 )
fibrosarcoma
71
71
8530350 (2), 9716492 (2), 15147870 (2), 18222489 (2) (see all 50 )
glioma
62.8
228
17593815 (7), 11517976 (6), 15743799 (6), 18652821 (6) (see all 82 )
cancer invasiveness
61.4
10
15349101 (1), 11172680 (1), 15492268 (1), 19056927 (1) (see all 6 )
glioblastoma
60.6
72
9219724 (4), 10389763 (4), 9708803 (4), 10895974 (3) (see all 34 )
melanoma
60.3
293
18187184 (10), 10878545 (6), 9875140 (6), 16045689 (6) (see all 99 )
carcinoma squamous cell
59.6
143
16708802 (6), 14990972 (5), 20510080 (4), 19088827 (4) (see all 80 )
liver fibrosis
59.5
36
15482348 (4), 18217401 (3), 9397993 (2), 10498646 (2) (see all 23 )
Genetic Association Database (GAD): MMP2 Human Genome Epidemiology (HuGE) Navigator: MMP2 (160 documents) Export disorders for MMP2 gene to outside databases
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Publicationsfor MMP2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MMP2 gene, integrated from 9 sources (see all 3626 ): (articles sorted by number of sources associating them with MMP2) Utopia : connect your pdf to the dynamic world of online information
Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. (PubMed id 17435175) 1 , 2 , 9 Sariahmetoglu M....Schulz R. (2007) Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. (PubMed id 14604886) 1 , 4, 9 Zhou Y....Lin D. (2004) [Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2) and MMP-9 genes with risk of gastric cancer in a Chinese population.] (PubMed id 15522165) 1 , 4, 9 Zhang X.M....Lin D.X. (2004) The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. (PubMed id 16275157) 1 , 4, 9 O-Charoenrat P. and Khantapura P. (2006) Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. (PubMed id 15731163) 1 , 4, 9 Zhou Y....Lin D. (2005) Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (PubMed id 16082623) 1 , 4, 9 Eriksson P....Powell J.T. (2005) A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer. (PubMed id 15485653) 1 , 4, 9 Xu E....Xia X. (2004) A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. (PubMed id 12873995) 1 , 4, 9 Miao X....Lin D. (2003) Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor. (PubMed id 12147339) 1 , 2 , 9 Feng Y....Stallings W.C. (2002) Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. (PubMed id 16356191) 1 , 4, 9 Rodriguez-Lopez J....Gonzalez A. (2006)
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External Searches for MMP2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MMP2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing MMP2 gene
(According to HUGE )
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Specialized Databases showing MMP2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MMP2 gene: Search GeneIP for patents involving MMP2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MMP2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for MMP2 OriGene shRNA RFP for MMP2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MMP2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMP2 OriGene Protein Over-expression Lysate for MMP2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MMP2 OriGene 3'-UTR Clone for MMP2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MMP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MMP2 OriGene Custom Protein Services for MMP2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMP2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MMP2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MMP2 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMP2
Antibodies & Assays for MMP2  
Tocris compounds for MMP2
MMP2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2
ThermoFisher Antibody for MMP2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP2
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