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MMP2 Gene

protein-coding   GIFtS: 74
GCID: GC16P055424

Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase,...

(Previous names: matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase,...)
(Previous symbols: CLG4, CLG4A)
  See MMP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type
IV Collagenase)1 2
     MONA2 5
CLG4A1 2 3 5     Matrix Metalloproteinase 2 (Gelatinase A, 72kD Gelatinase, 72kD Type IV
Collagenase)1
CLG41 2     Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV
Collagenase)1
Gelatinase A2 3     72 KDa Type IV Collagenase2
Matrix Metalloproteinase-22 3     MMP-II2
72 KDa Gelatinase2 3     Collagenase Type IV-A2
MMP-22 3     Matrix Metalloproteinase-II2
TBE-12 3     Neutrophil Gelatinase2
EC 3.4.24.243 8     EC 3.4.248

External Ids:    HGNC: 71661   Entrez Gene: 43132   Ensembl: ENSG000000872457   OMIM: 1203605   UniProtKB: P082533   

Export aliases for MMP2 gene to outside databases

Previous GC identifers: GC16P045928 GC16P055478 GC16P055161 GC16P055291 GC16P054070 GC16P041400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP2 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen,
the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown,
regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with
Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP2 Gene:
MMP2 (matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)) is a protein-coding gene. Diseases associated with MMP2 include multicentric osteolysis of torg, and torg winchester syndrome. GO annotations related to this gene include metalloendopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the
vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As
well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big
endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to
have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the
activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in
association with MMP14
Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties
and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface
of blood vessels
Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by
inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF
transcriptional pathways

summary for MMP2 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP2 gene promoter:
         SRF   Sp1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP2 promoter sequence
   Search Chromatin IP Primers for MMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13-q21

MMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055424:  view genomic region     (about GC identifiers)

Start:
55,423,612 bp from pter      End:
55,540,603 bp from pter
Size:
116,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253 (See protein sequence)
Recommended Name: 72 kDa type IV collagenase precursor  
Size: 660 amino acids; 73882 Da
Cofactor: Binds 4 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Subunit: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3;
the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the
C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity.
Interacts with GSK3B
Selected PDB 3D structures from and Proteopedia for MMP2 (see all 11):
1CK7 (3D)        1CXW (3D)        1EAK (3D)        1GEN (3D)        1GXD (3D)        1HOV (3D)    
Secondary accessions: B2R6U1 B4DWH3 E9PE45 Q9UCJ8
Alternative splicing: 3 isoforms:  P08253-1   P08253-2   P08253-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MMP2: NX_P08253

Explore proteomics data for MMP2 at MOPED

Post-translational modifications: 

  • Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro1
  • The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal
    produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta31
  • Glycosylation2 at Asn573, Asn642
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP2 (P08253) (see all 26)
     DGYPFDG  YNFFPRK  GEADIMI  GLLAHAF 


    See MMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121363.1  NP_004521.1  

    ENSEMBL proteins: 
     ENSP00000461421   ENSP00000457949   ENSP00000219070   ENSP00000456096   ENSP00000444143  
     ENSP00000394237   ENSP00000456518   ENSP00000461915  
    Reactome Protein details: P08253

    MMP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP2 (MMP-2)
    Enzo Life Sciences proteins for MMP2
    OriGene Purified Proteins for MMP2
    OriGene Protein Over-expression Lysate for MMP2
    OriGene MassSpec for MMP2
    OriGene Custom Protein Services for MMP2
    GenScript Custom Purified and Recombinant Proteins Services for MMP2
    Novus Biologicals MMP2 Proteins
    Novus Biologicals MMP2 Lysates
    Sino Biological Recombinant Protein for MMP2
    Sino Biological Cell Lysate for MMP2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP2

     
    Search eBioscience for Proteins for MMP2 

    MMP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP2
    R&D Systems Antibodies for MMP2 (MMP-2)
    Cell Signaling Technology (CST) Antibodies for MMP2 
    OriGene Antibodies for MMP2
    OriGene Custom Antibody Services for MMP2
    Novus Biologicals MMP2 Antibodies
    Abcam antibodies for MMP2
    Cloud-Clone Corp. Antibodies for MMP2
    ThermoFisher Antibody for MMP2
    LSBio Antibodies in human, mouse, rat for MMP2

    MMP2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MMP2
    OriGene Custom Assay Services for MMP2
    R&D Systems ELISAs for MMP2 (MMP-2)         (see all)
    GenScript MMP2-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP2
    Cloud-Clone Corp. ELISAs for MMP2
    Cloud-Clone Corp. CLIAs for MMP2
    Search eBioscience for ELISAs for MMP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP2
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 12):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P08253

    ProtoNet protein and cluster: P08253

    3 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 3 fibronectin type-II domains
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP2_HUMAN, P08253
    Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the
    vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As
    well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big
    endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to
    have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the
    activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in
    association with MMP14
    Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties
    and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface
    of blood vessels
    Function: Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by
    inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF
    transcriptional pathways
    Catalytic activity: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like
    sequence Pro-Gln-Gly- -Ile-Ala-Gly-Gln
    Enzyme regulation: Inhibited by histatin-3 1/24 (histatin-5)
    Induction: Aspirin appears to inhibit expression

         Genatlas biochemistry entry for MMP2:
    matrix metalloproteinase 2,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen
    and intestine,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,overexpressed
    in inflammatory bowel diseases

         Enzyme Numbers (IUBMB): EC 3.4.24.241 2 EC 3.4.242

         Summary: 
    During embryonic development, MMP2 as signaling molecule is secreted from the following cells:
                
    Mesoderm: Septum Transversum Mesenchyme Cells (Septum Transversum)

    It affects the following cells:
    Liver: Hepatoblasts (Liver Bud)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MMP2:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp2):
     cardiovascular system  craniofacial  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  normal 
     respiratory system  skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with MMP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmp2tm1Ito for MMP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP2:
    hsa-mir-451a (MIRT005742), hsa-mir-21-5p (MIRT030716), hsa-mir-335-5p (MIRT018099), hsa-mir-17-5p (MIRT031370), hsa-mir-338-3p (MIRT019228), hsa-mir-29b-3p (MIRT005570)

    Block miRNA regulation of human, mouse, rat MMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP2 (see all 27):
    hsa-miR-3164 hsa-miR-2110 hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-519a hsa-miR-511 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidMMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP2
    Predesigned siRNA for gene silencing in human, mouse, rat MMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP2

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP2 (see all 12)
    OriGene ORF clones in mouse, rat for MMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MMP2 (NM_004530)
    Sino Biological Human cDNA Clone for MMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2
    Addgene plasmids for MMP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP2
    ESI BIO PureStem Progenitors for MMP2: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10113) for MMP2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP2_HUMAN, P08253: Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus.
    Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas.
    Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
    MMP2_HUMAN, P08253: Isoform 2: Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion5
    nucleus5
    cytoskeleton3
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA18492766
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with MMP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP2 About   (see all 34)  
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    4Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    5Development Endothelin 1 EDNRA signaling
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34


    Find genes that share SuperPaths with MMP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for MMP2
        A-beta Uptake & Degradation
    A-beta Plaque Formation & APP Metabolism

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP2 (see all 6)
        Glioma Invasiveness
    Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    3 Cell Signaling Technology (CST) Pathways for MMP2
        Angiogenesis
    Adhesion
    Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for MMP2
        Transcription Androgen Receptor nuclear signaling
    Transcription P53 signaling pathway
    Development EGFR signaling pathway
    Cell adhesion ECM remodeling

    Selected BioSystems Pathways for MMP2 (see all 14)
        Matrix Metalloproteinases
    AGE/RAGE pathway
    IL-3 Signaling Pathway
    LPA receptor mediated events
    Osteopontin-mediated events


    4 Reactome Pathways for MMP2
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases


    Selected Kegg Pathways  (Kegg details for MMP2) (see all 6):
        Leukocyte transendothelial migration
    GnRH signaling pathway
    Estrogen signaling pathway
    Pathways in cancer
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP2 (see all 14): 
              Osteogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MMP2 (P082531, 3 ENSP000002190704) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL7P800983, ENSP000002003074I2D: score=3 STRING: ENSP00000200307
    COL1A1P024523, ENSP000002259644I2D: score=2 STRING: ENSP00000225964
    LCN2P801883, ENSP000002774804I2D: score=2 STRING: ENSP00000277480
    LGALS3P179313, ENSP000002543014I2D: score=2 STRING: ENSP00000254301
    THBS2P354423, ENSP000003557514I2D: score=2 STRING: ENSP00000355751
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001955blood vessel maturation IEA--
    GO:0001957intramembranous ossification IEA--
    GO:0006508proteolysis TAS2834383

    Find genes that share ontologies with MMP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP2
    Selected ApexBio Compounds for MMP2 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for MMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2targetinhibitor19057128 10328230 15993560 20184869 12381651 17308006
    Marimastat-- 154039-60-8targetinhibitor12527923 15748894 11790786 15056115 11752352 10460642
    SC-74020SC 74020 (see all 2)--target--17139284 17016423

    1 IUPHAR Ligand for MMP2 (MMP2)    About this table
    LigandTypeActionAffinityPubmed IDs
    ARP100
    InhibitorInhibition16483784

    Selected Novoseek inferred chemical compound relationships for MMP2 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 88.6 110 9413149 (4), 8292337 (3), 10491398 (3), 11431735 (2) (see all 82)
    (4-aminophenyl)mercuric acetate 80 23 1480033 (3), 2269296 (2), 9628251 (1), 7896811 (1) (see all 9)
    batimastat 78.7 10 9816289 (1), 11598905 (1), 10585576 (1), 11276015 (1) (see all 7)
    ilomastat 78.4 18 17512742 (2), 18665992 (2), 18465841 (1), 20299089 (1) (see all 10)
    vegf 75.7 623 16584583 (8), 16875630 (6), 16124061 (6), 16962110 (6) (see all 99)
    marimastat 67 4 12405288 (1), 12527923 (1), 19735728 (1)
    prinomastat 64.5 9 11060800 (1), 16483784 (1), 20215503 (1), 10415735 (1) (see all 5)
    cgs-27023a 63 2 15080939 (1), 11948136 (1)
    col 3 61 10 12850461 (3), 16205320 (2), 11469893 (1), 11320090 (1) (see all 7)
    hydroxamate 59.5 17 12147339 (2), 12475252 (1), 15781326 (1), 9548812 (1) (see all 8)



    Find genes that share compounds with MMP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP2 gene (2 alternative transcripts): 
    NM_001127891.1  NM_004530.4  

    Unigene Cluster for MMP2:

    Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
    Hs.513617  [show with all ESTs]
    Unigene Representative Sequence: NM_004530
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570308 ENST00000568715 ENST00000219070(uc002ehz.4 uc010vhd.2 uc010ccc.3)
    ENST00000564864 ENST00000543485 ENST00000437642 ENST00000570283 ENST00000566564

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    Selected qRT-PCR Assays for microRNAs that regulate MMP2 (see all 27):
    hsa-miR-3164 hsa-miR-2110 hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-519a hsa-miR-511 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidMMP2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): MMP2 (NM_004530)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2
    Addgene plasmids for MMP2 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10113) for MMP2 

    Additional mRNA sequence: 

    AK057680.1 AK301536.1 AK310314.1 AK312711.1 AL832088.1 BC002576.2 DQ385623.1 J03210.1 
    X58968.1 

    Selected DOTS entries (see all 35):

    DT.95130460  DT.100652571  DT.75124861  DT.92058175  DT.100762889  DT.101985660  DT.92462977  DT.100637823 
    DT.120668918  DT.120668959  DT.120668954  DT.91892990  DT.95336528  DT.100646179  DT.120668946  DT.120669002 
    DT.95091235  DT.120668909  DT.120668975  DT.92462967  DT.92462969  DT.92462976  DT.100722515  DT.120668915 

    Selected AceView cDNA sequences (see all 601):

    CA430373 BQ675400 CF128287 CA412514 BP345624 BI832444 BM994073 AI754338 
    AI752103 BM988400 BP345957 AW173771 BX386175 CN480197 BU158122 BQ001034 
    X58968 T27798 AA513459 CO246414 AU279704 BM725839 AA369008 AA304614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATGTCA
    MMP2 Expression
    About this image


    MMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 35) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
     
     Tooth (Integumentary System)    fully expand to see all 8 entries
             Odontoblasts Dentin
             Dentin
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Meckel's Cartilage
    MMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513617

    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
    Tissue specificity: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas,
    breast and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP2 (see all 14): 
              Osteogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp21 , 5 matrix metallopeptidase 21, 5 89.44(n)1
    95.91(a)1
      8 (44.99 cM)5
    173901  NM_008610.21  NP_032636.11 
     928273285 
    chicken
    (Gallus gallus)
    Aves MMP21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, more 75.53(n)
    83.93(a)
      386583  NM_204420.2  NP_989751.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP26
    matrix metallopeptidase 2 (gelatinase A, 72kDa gel...
    82(a)
    1 ↔ 1
    LGc(2265381-2309677)
    African clawed frog
    (Xenopus laevis)
    Amphibia Mmp22 matrix metalloproteinase 2 76.61(n)    AY037943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp22 matrix metalloproteinase 2 77.22(n)   337179  AY324195.1 
    worm
    (Caenorhabditis elegans)
    Secernentea H19M22.36
    zmp-16
    Protein ZMP-1 (zmp-1) mRNA, complete cds
    22(a)
    20(a)
    many ↔ many
    many ↔ many
    III(2636405-2642848) WBGene00019212
    III(5926898-5932953) WBGene00006987


    ENSEMBL Gene Tree for MMP2 (if available)
    TreeFam Gene Tree for MMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP2 gene
    MMP212  MMP23B2  MMP92  MMP192  MMP262  ELSPBP12  
    13 SIMAP similar genes for MMP2 using alignment to 5 protein entries:     MMP2_HUMAN (see all proteins):
    MMP15    MMP7    ELSPBP1    MMP1    MMP26    MMP10
    MMP3    MMP9    MMP8    MMP13    MMP17    mmp20
    MMP14

    Find genes that share paralogs with MMP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP2 (see all 830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0324234
    Multicentric osteolysis, nodulosis, and arthropathy (MONA)4--see VAR_0324232 R H mis40--------
    VAR_0361364
    A colorectal cancer sample4--see VAR_0361362 A T mis40--------
    VAR_0361374
    A colorectal cancer sample4--see VAR_0361372 T M mis40--------
    VAR_0361384
    A colorectal cancer sample4--see VAR_0361382 S I mis40--------
    VAR_0324254
    Multicentric osteolysis, nodulosis, and arthropathy (MONA)4--see VAR_0324252 E K mis40--------
    rs711496171,2
    C--41401325(+) GGGGG-/G/GG  
            
    GCGGT
    2 -- int1 us2k12NA CSA 4
    rs719914121,2
    C--41407659(+) AATGC-/GTGT  
            
    GTGTG
    2 -- int10--------
    rs713930831,2
    C,F--41426242(+) CAGGCG/ATGAGC 2 -- int12Minor allele frequency- A:0.50NA 4
    rs2006820911,2
    C--55513891(+) TTTGG-/GC/GG 
            
    GGGGG
    2 -- int1 us2k10--------
    rs178598651,2
    C,F--55517378(+) CACAGAG/-CAAGA 2 -- int11Minor allele frequency- -:0.02NS 150

    HapMap Linkage Disequilibrium report for MMP2 (55423612 - 55540603 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP2: --
    Human Gene Mutation Database (HGMD): MMP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120360   
    OMIM disorders: 259600  
    UniProtKB/Swiss-Prot: MMP2_HUMAN, P08253
  • Multicentric osteolysis, nodulosis, and arthropathy (MONA) [MIM:259600]: An autosomal recessive syndrome
    characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional
    features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and
    gum hypertrophy. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for MMP2 (see all 32):    
    About MalaCards
    multicentric osteolysis of torg    torg winchester syndrome    arthropathy    nasal cavity squamous cell carcinoma
    klatskin's tumor    granuloma annulare    focal myositis    myocardial infarction susceptibility
    microcystic meningioma    intestinal neoplasm    lentigo maligna melanoma    lymphangioleiomyomatosis
    arthritis    fibromatosis, gingival    fibromatosis    conjunctivochalasis
    corneal ulcer    sialadenitis    parotitis    lung giant cell carcinoma

    Selected diseases from the University of Copenhagen DISEASES database for MMP2 (see all 21):
    Vascular disease     Carcinoma     Malignant glioma     Heart disease
    Breast cancer     Melanoma     Lung cancer     Arthritis
    Ovarian cancer     Lung disease     Hepatocellular carcinoma     Prostate cancer
    Periodontal disease     Colorectal cancer     Pancreatic cancer     Keratitis
    Brain disease     Fibrosarcoma     Urinary bladder cancer     Kidney disease

    Find genes that share disorders with MMP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MMP2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 83.8 859 11594775 (5), 9772533 (5), 11903578 (5), 9291433 (5) (see all 99)
    tumors 78.7 1819 16425263 (7), 16581051 (6), 10366463 (6), 12218298 (6) (see all 99)
    cancer 72 578 19360311 (6), 10861469 (5), 8611434 (4), 10971291 (4) (see all 99)
    fibrosarcoma 71 71 8530350 (2), 9716492 (2), 15147870 (2), 18222489 (2) (see all 50)
    glioma 62.8 228 17593815 (7), 11517976 (6), 15743799 (6), 18652821 (6) (see all 82)
    cancer invasiveness 61.4 10 15349101 (1), 11172680 (1), 15492268 (1), 19056927 (1) (see all 6)
    glioblastoma 60.6 72 9219724 (4), 10389763 (4), 9708803 (4), 10895974 (3) (see all 34)
    melanoma 60.3 293 18187184 (10), 10878545 (6), 9875140 (6), 16045689 (6) (see all 99)
    carcinoma squamous cell 59.6 143 16708802 (6), 14990972 (5), 20510080 (4), 19088827 (4) (see all 80)
    liver fibrosis 59.5 36 15482348 (4), 18217401 (3), 9397993 (2), 10498646 (2) (see all 23)

    Genetic Association Database (GAD): MMP2
    Human Genome Epidemiology (HuGE) Navigator: MMP2 (160 documents)

    Export disorders for MMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP2 gene, integrated from 10 sources (see all 3768):
    (articles sorted by number of sources associating them with MMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. (PubMed id 17435175)1, 2, 9 Sariahmetoglu M....Schulz R. (FASEB J. 2007)
    2. Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer. (PubMed id 17236757)1, 4, 9 Wu C.Y....Lin J.T. (Eur. J. Cancer 2007)
    3. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PubMed id 20113256)1, 4, 9 Yi Y.C....Yang S.F. (Clin. Chem. Lab. Med. 2010)
    4. Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population. (PubMed id 20110530)1, 4, 9 Wipff J....Allanore Y. (J. Rheumatol. 2010)
    5. MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (PubMed id 17448043)1, 4, 9 Chen D....Wu Z.F. (J. Clin. Periodontol. 2007)
    6. Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression. (PubMed id 17958893)1, 4, 9 Cotignola J....Orlow I. (J Negat Results Biomed 2007)
    7. Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. (PubMed id 14604886)1, 4, 9 Zhou Y....Lin D. (Carcinogenesis 2004)
    8. Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms). (PubMed id 18802702)1, 4, 9 Barlas I.O....TA1rkmen E. (Rheumatol. Int. 2009)
    9. Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis. (PubMed id 18155181)1, 4, 9 GA1rkan A....Berdeli A. (Arch. Oral Biol. 2008)
    10. [Study on the association of SNPs of MMP-2 and TIMP-2 genes with the risk of endometriosis and adenomyosis]. (PubMed id 18543216)1, 4, 9 Zhao X.W....Kang S. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4313 HGNC: 7166 AceView: MMP2 Ensembl:ENSG00000087245 euGenes: HUgn4313
    ECgene: MMP2 Kegg: 4313 H-InvDB: MMP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP2 gene:
    Search GeneIP for patents involving MMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Proteins for MMP2
     Antibodies for MMP2
     ELISAs for MMP2
     CLIAs for MMP2



     PureStem Progenitors for MMP2: PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem Z11, Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP2
     SwitchGear 3'UTR luciferase reporter plasmids for MMP2
     SwitchGear Promoter luciferase reporter plasmids for MMP2
     ThermoFisher Antibody for MMP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP2
     LSBio Antibodies in human, mouse, rat for MMP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for MMP2
     Addgene plasmids for MMP2
      Search eBioscience for proteins for MMP2
      Search eBioscience for elisas for MMP2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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