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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP19 Gene

protein-coding GIFtS: 63
GCID: GC12M056230

matrix metallopeptidase 19

(Previous name: matrix metalloproteinase 19 )
(Previous symbol: MMP18)

Explore 24 diseases affiliated with
MMP19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 19¹ ²		Matrix Metalloproteinase-19²
MMP18¹ ² ³ ⁵		Matrix Metalloproteinase-Beta19²
RASI-1¹ ²		EC 3.4.24.-³
Matrix Metalloproteinase RASI² ³		MMP-18³
Matrix Metalloproteinase-18² ³		MMP-19³
Matrix Metalloproteinase 19¹		RASI³

External Ids:	HGNC: 7165¹	Entrez Gene: 4327²	Ensembl: ENSG00000123342⁷	OMIM: 601807⁵	UniProtKB: Q99542³

Export aliases for MMP19 gene to outside databases

Previous GC identifers: GC12M056347 GC12M056451 GC12M055945 GC12M054515 GC12M053267

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP19:

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is

activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for

this gene. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542

Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage

oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May

also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C

isoform, fibronectin, and type I gelatin

summary for MMP19:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP19 gene promoter:
c-Fos AML1a AP-1 FosB YY1 JunD Nkx6-1 NRF-2 c-Jun TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP19 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q14

MMP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP19 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M056230: view genomic region (about GC identifiers)

Start:	56,229,214 bp from pter	End:	56,236,750 bp from pter
Size:	7,537 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542 (See protein sequence)

Recommended Name: Matrix metalloproteinase-19 precursor

Size: 508 amino acids; 57357 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Cofactor: Calcium (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Sequence caution: Sequence=AAC99995.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: O15278 O95606 Q99580

Alternative splicing: 3 isoforms: Q99542-1 Q99542-3 Q99542-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MMP19: NX_Q99542

Post-translational modifications:

Activated by autolytic cleavage after Lys-97¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99542

MMP19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001259030.1 NP_002420.1

ENSEMBL proteins:

ENSP00000447363 ENSP00000313437 ENSP00000446776 ENSP00000446979 ENSP00000386625

ENSP00000449752 ENSP00000377736

Reactome Protein details: Q99542
Human Recombinant Protein Products for MMP19:

	EMD Millipore Purified and/or Recombinant MMP19 Protein
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	OriGene Purified Protein: MMP19 OriGene Protein Over-expression Lysate: MMP19 OriGene Custom Protein Services for MMP19
	GenScript Custom Purified and Recombinant Proteins Services for MMP19
	Novus Biologicals MMP19 Protein Novus Biologicals MMP19 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MMP19

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	NAS	10809722
GO:0031012	extracellular matrix	--	--

MMP19 for ontologies About GeneDecksing

MMP19 Antibody Products:

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	Novus Biologicals MMP19 Antibodies
	Abcam antibodies for MMP19
	Uscn Antibodies for MMP19
	ThermoFisher Antibodies for MMP19

Assay Products for MMP19:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MMP19
	Enzo Life Sciences assays for MMP19
	Uscn ELISAs and CLIAs for MMP19

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP19 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR024079 MetalloPept_cat_dom

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018487 Hemopexin/matrixin_repeat

IPR006026 Peptidase_Metallo

Graphical View of Domain Structure for InterPro Entry Q99542

ProtoNet protein and cluster: Q99542

1 Blocks protein family: IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MMP19_HUMAN, Q99542

Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage

oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May

also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C

isoform, fibronectin, and type I gelatin

Catalytic activity: Cleaves aggrecan at the 360-Ser- -Phe-361 site

Enzyme regulation: Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient

Genatlas biochemistry entry for MMP19:

matrix metalloproteinase 19,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and

intestine

Enzyme Number (IUBMB): EC 3.4.24.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP19 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp19):

adipose tissue

growth/size

homeostasis/metabolism

tumorigenesis

MMP19 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mmp19^tm1Amp for MMP19

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MMP19

miRNA Products:		OriGene 3'-UTR Clone: MMP19 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP19
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP19 (see all 23):
		hsa-miR-320a hsa-miR-1321 hsa-miR-193a-3p hsa-miR-431 hsa-miR-1285 hsa-miR-513c hsa-miR-3154 hsa-miR-320e

		SwitchGear 3'UTR luciferase reporter plasmid: MMP19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP19 (see all 7) OriGene shRNA RFP: MMP19 OriGene siRNA: MMP19
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP19
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP19

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MMP19
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP19 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP19 (NM_002429)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP19
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP19

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP19
		Search LifeMap BioReagents cell lines for MMP19
		Sirion Biotech Customized stable knockdown cell line services for MMP19 Sirion Biotech Customized inducible knockdown cell line services for MMP19 Sirion Biotech Customized stable overexpressing cell line services for MMP19 Sirion Biotech Customized inducible overexpressing cell line services for MMP19

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP19

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

Degradation of the extracellular matrix

1.00

Degradation of collagen

0.79

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

Integrin Pathway

UPA-UPAR Pathway

0.51

Transendothelial Migration of Leukocytes

0.38

Gelatin degradation by MMP19

Gelatin degradation by MMP19

1.00

Gelatin degradation by MMP19

Gelatin degradation by MMP19

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MMP19

Metalloproteases in connective tissue degradation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP19

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 BioSystems Pathway for MMP19

Matrix Metalloproteinases

5 Reactome Pathways for MMP19

	Gelatin degradation by MMP19
	Extracellular matrix organization
	Gelatin degradation by MMP19
	Degradation of the extracellular matrix
	Degradation of collagen

MMP19 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP19

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MMP19 (ENSP00000313437⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	ENSP00000268134⁴	STRING: ENSP00000268134

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001541	ovarian follicle development	IEA	--
GO:0001542	ovulation from ovarian follicle	IEA	--
GO:0001554	luteolysis	IEA	--
GO:0006508	proteolysis	NAS	9020145

MMP19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP19 for compounds About GeneDecksing

EMD Millipore small molecules for MMP19:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for MMP19 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP19 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MMP19 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951

2 Novoseek chemical compound relationships for MMP19 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha tocopherol	38.4	2	15134510 (1)
matrigel	26.5	6	15241558 (3), 16707448 (1)

Search CenterWatch for drugs/clinical trials and news about MMP19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP19 gene (5 alternative transcripts):

NM_001272101.1 NM_002429.5 NM_001032360.1 NM_022790.1 NM_022792.2

Unigene Cluster for MMP19:

Matrix metallopeptidase 19

Hs.591033 [show with all ESTs]

Unigene Representative Sequence: U38320

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000548882(uc001sia.3 uc001sib.3 uc001sid.3 uc010spw.2)

ENST00000547685 ENST00000322569 ENST00000552872 ENST00000548629 ENST00000409200

ENST00000552763 ENST00000547487 ENST00000547299 ENST00000394182

miRNA Products:		OriGene 3'-UTR Clone: MMP19 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP19
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP19 (see all 23):
		hsa-miR-320a hsa-miR-1321 hsa-miR-193a-3p hsa-miR-431 hsa-miR-1285 hsa-miR-513c hsa-miR-3154 hsa-miR-320e

		SwitchGear 3'UTR luciferase reporter plasmid: MMP19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP19 (see all 7) OriGene shRNA RFP: MMP19 OriGene siRNA: MMP19
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP19
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP19

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP19 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP19 (NM_002429)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP19
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP19

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP19
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP19

Additional cDNA sequence:

AK225939.1 AK297999.1 AK303202.1 BC050368.1 U37791.1 U38320.1 U38321.1 U38322.1

U38431.1 X92521.1 Y08622.1

14 DOTS entries:

DT.102838718 DT.91768200 DT.95264149 DT.86840499 DT.75126070 DT.100025194 DT.121194776 DT.100784521

DT.121194788 DT.91768208 DT.91862367 DT.91768198 DT.121194793 DT.121194800

24/105 AceView cDNA sequences (see all 105):

CB528762 CD368816 CK819809 AI682896 U38431 X92521 AW339116 AI692430

AI619886 CR620332 AW079471 NM_022791 U37791 BF001361 AA838485 AL551172

NM_022792 AA586829 U38321 AW190715 AW235989 BU688502 BC050368 AA778742

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MMP19 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9a	·	9b
SP1:													-												-										-		-
SP2:													-		-										-
SP3:													-												-
SP4:													-								-				-
SP5:													-		-		-		-		-		-		-										-		-

ECgene alternative splicing isoforms for MMP19

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATAAAAA

About this image
See MMP19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP19

SOURCE GeneReport for Unigene cluster: Hs.591033

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542

Tissue specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus,

prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also

expressed in the synovial fluid of normal and rheumatoid patients

SABiosciences Custom PCR Arrays for MMP19

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP19 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP19

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP19 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP28⁶	Uncharacterized protein	34(a)	1 ↔ 1	19(4336774-4342361)
lizard (Anolis carolinensis)	Reptilia	MMP19⁶ MMP3⁶	--	60(a) 24(a)	1 ↔ 1 possible ortholog	GL343198.1(3158633-3179784) GL344472.1(307-4612)
zebrafish (Danio rerio)	Actinopterygii	LOC100536874¹	matrix metalloproteinase-19-like	59.92(n) 56.54(a)		100536874 XM_003199413.1 XP_003199461.1
worm (Caenorhabditis elegans)	Secernentea	C31B8.8⁶ H19M22.3⁶	Protein H19M22.3, isoform a	21(a) 15(a)	1 ↔ 1 possible ortholog	V(2905762-2909681) III(2636396-2642839)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT4G16640⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	25(a) 24(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 4(9367248-9368775)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	9(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 10(21883516-21885765)

ENSEMBL Gene Tree for MMP19 (if available)
TreeFam Gene Tree for MMP19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP19 gene

MMP21² MMP23B² MMP7² MMP26²

15 SIMAP similar genes for MMP19 using alignment to 5 protein entries: MMP19_HUMAN (see all proteins):

MMP7 MMP26 MMP10 MMP11 MMP17 mmp20

MMP13 MMP24 MMP27 MMP1 MMP16 MMP12

MMP14 MMP25 MMP28

MMP19 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11834857^1,2	C,F,H	--	53267687(+)	`gtgatC/Actcct`	1	--	ut3¹ ese³		4		NA NS	186
rs3208945^1,2	C	--	53267887(+)	`CCCAAC/TCTCCA`	1	--	ut3¹ ese³		3		MN NA	188
rs76037300^1,2	C,F	--	53268288(+)	`TCCTGC/TGCAGG`	1	--	ut3¹		1		EA	120
rs715817^1,2	C,F,O,H	--	53268696(+)	`TACTGG/ATCTTA`	1	--	ut3¹		12		MN NS EA NA	1250
rs142573130^1,2		--	56228738(+)	`TGTACA/CCCTCA`	4	--	nc-transcript-variant		0	--	--	--	--
rs146505472^1,2		--	56228740(+)	`TACCCC/GTCACC`	4	--	nc-transcript-variant		0	--	--	--	--
rs185031466^1,2		--	56228918(+)	`CTTTGA/TAGGGA`	4	--	nc-transcript-variant		0	--	--	--	--
rs189928516^1,2		--	56229396(+)	`CTCACA/GGTGGT`	4	--	nc-transcript-variant		0	--	--	--	--
rs17844808^1,2	C,F	--	56229691(-)	`GAAGG-/GCAGGT`	4	--	nc-transcript-variant		1		NS	164
rs140424920^1,2		--	56230075(+)	`CTCTGC/TACCCC`	4	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MMP19 (56229214 - 56236750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP19: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP19

DNA2.0 Custom Variant and Variant Library Synthesis for MMP19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP19 for disorders About GeneDecksing

OMIM gene information: 601807 OMIM disorders: --

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542

Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint

tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients

20/24 diseases for MMP19 (see all 24): About MalaCards

arthritis relapsing-remitting multiple sclerosis encephalomyelitis graft versus host disease

multiple sclerosis rheumatoid arthritis keratoacanthoma skin cancer

malignant glioma squamous cell carcinoma chordoma keloids

psoriasis chondrosarcoma colon cancer breast cancer

ischemia obesity carcinoma cerebritis

10/13 Novoseek disease relationships for MMP19 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
squamous cell cancer	53.3	2	15868410 (1)
skin cancer	32.7	2	12516088 (1), 15169894 (1)
invasive cancer	32.2	1	14694517 (1)
neovascularization	30.4	1	9232430 (1)
rheumatoid arthritis	27.2	5	9232430 (1), 15169894 (1), 9562866 (1), 10388526 (1)
multiple sclerosis	21.6	1	17083473 (1)
tumors	17.7	20	18161657 (3), 17980449 (2), 20142769 (2), 16707448 (2) (see all 10)
psoriasis	11.8	3	12735638 (2), 14708597 (1)
cancer	9.85	6	12516088 (2), 18651563 (1), 15169894 (1), 18286480 (1)
inflammation	5.38	2	10388526 (1)

Human Genome Epidemiology (HuGE) Navigator: MMP19 (8 documents)

Export disorders for MMP19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP19 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with MMP19)

Utopia: connect your pdf to the dynamic
world of online information

The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient. (PubMed id 9232430)^{1, 2, 3, 9} Kolb C.... Sedlacek R. (1997)
Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. (PubMed id 10809722)^{1, 2, 9} Stracke J.O.... Knaeuper V. (2000)
Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution. (PubMed id 9020145)^{1, 2, 9} Pendas A.M.... Lopez-Otin C. (1997)
Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). (PubMed id 10922468)^{1, 2, 9} Stracke J.O.... Knaeuper V. (2000)
Identification of MMP-18, a putative novel human matrix metalloproteinase. (PubMed id 8920941)^{1, 2, 9} Cossins J.... Clements J.M. (1996)
Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis. (PubMed id 9562866)^{1, 2, 9} Sedlacek R.... Krawinkel U. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. (PubMed id 14708598)^{1, 9} Hieta N....Kahari V.M. (2003)
Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface. (PubMed id 11801661)^{1, 9} Mauch S....Sedlacek R. (2002)
Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesions. (PubMed id 17083473)^{1, 9} van Horssen J....de Vries H.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4327	HGNC: 7165	AceView: MMP19	Ensembl:ENSG00000123342	euGenes: HUgn4327
ECgene: MMP19	H-InvDB: MMP19

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP19	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP19	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp19/

Intellectual Property for MMP19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP19 gene:
Search GeneIP for patents involving MMP19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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matrix metallopeptidase 19

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MMP19 Gene

matrix metallopeptidase 19

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