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MMP19 Gene

protein-coding   GIFtS: 69
GCID: GC12M056230

Matrix Metallopeptidase 19

(Previous name: matrix metalloproteinase 19)
(Previous symbol: MMP18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 191 2     Matrix Metalloproteinase-192
MMP181 2 3 5     Matrix Metalloproteinase-Beta192
Matrix Metalloproteinase RASI2 3     EC 3.4.24.-3
Matrix Metalloproteinase-182 3     MMP-183
Matrix Metalloproteinase 191     MMP-193
RASI-12     RASI3

External Ids:    HGNC: 71651   Entrez Gene: 43272   Ensembl: ENSG000001233427   OMIM: 6018075   UniProtKB: Q995423   

Export aliases for MMP19 gene to outside databases

Previous GC identifers: GC12M056347 GC12M056451 GC12M055945 GC12M054515 GC12M053267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP19 Gene:
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein,
which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript
variants for this gene. (provided by RefSeq, Jan 2013)

GeneCards Summary for MMP19 Gene:
MMP19 (matrix metallopeptidase 19) is a protein-coding gene. Diseases associated with MMP19 include encephalomyelitis, and relapsing-remitting multiple sclerosis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542
Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and
cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions
(arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV,
laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin

summary for MMP19 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP19 gene promoter:
         c-Fos   AML1a   AP-1   FosB   YY1   JunD   Nkx6-1   NRF-2   c-Jun   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP19 promoter sequence
   Search Chromatin IP Primers for MMP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q14

MMP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP19 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056230:  view genomic region     (about GC identifiers)

Start:
56,229,214 bp from pter      End:
56,236,750 bp from pter
Size:
7,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542 (See protein sequence)
Recommended Name: Matrix metalloproteinase-19 precursor  
Size: 508 amino acids; 57357 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Sequence caution: Sequence=AAC99995.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: O15278 O95606 Q99580
Alternative splicing: 3 isoforms:  Q99542-1   Q99542-3   Q99542-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MMP19: NX_Q99542

Explore proteomics data for MMP19 at MOPED

Post-translational modifications: 

  • Activated by autolytic cleavage after Lys-971
  • Glycosylation2 at Asn464
  • Modification sites at PhosphoSitePlus

  • See MMP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001259030.1  NP_002420.1  

    ENSEMBL proteins: 
     ENSP00000447363   ENSP00000313437   ENSP00000446776   ENSP00000446979   ENSP00000386625  
     ENSP00000449752   ENSP00000377736  
    Reactome Protein details: Q99542

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    Cloud-Clone Corp. CLIAs for MMP19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP19
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 9):
     IPR028724 MMP19
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat

    Graphical View of Domain Structure for InterPro Entry Q99542

    ProtoNet protein and cluster: Q99542

    1 Blocks protein domain: IPB002477 Putative peptidoglycan binding domain 1

    UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP19_HUMAN, Q99542
    Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and
    cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions
    (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV,
    laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin
    Catalytic activity: Cleaves aggrecan at the 360-Ser- -Phe-361 site
    Enzyme regulation: Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient

         Genatlas biochemistry entry for MMP19:
    matrix metalloproteinase 19,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen
    and intestine

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP19 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp19):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     tumorigenesis 

    MMP19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MMP19: Mmp19tm1Amp Mmp19tm1Rase

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP19
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP19

    miRNA
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    hsa-mir-124-3p (MIRT023166)

    Block miRNA regulation of human, mouse, rat MMP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP19 (see all 23):
    hsa-miR-320a hsa-miR-1321 hsa-miR-193a-3p hsa-miR-431 hsa-miR-1285 hsa-miR-513c hsa-miR-3154 hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmidMMP19 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MMP19

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MMP19 (NM_002429)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP19

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP19_HUMAN, Q99542: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS10809722
    GO:0031012extracellular matrix ----

    MMP19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP19 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    3Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    5Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP19
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP19
        Matrix Metalloproteinases

    2 Reactome Pathways for MMP19
        Degradation of the extracellular matrix
    Collagen degradation



    MMP19 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP19
    Interactions:

        GeneGlobe Interaction Network for MMP19

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MMP19 (ENSP000003134374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000002681344STRING: ENSP00000268134
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001541ovarian follicle development IEA--
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0001554luteolysis IEA--
    GO:0006508proteolysis NAS9020145

    MMP19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP19 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP19    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP19    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    2 Novoseek inferred chemical compound relationships for MMP19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha tocopherol 38.4 2 15134510 (1)
    matrigel 26.5 6 15241558 (3), 16707448 (1)



    MMP19 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP19 gene (5 alternative transcripts): 
    NM_001272101.1  NM_002429.5  NM_001032360.1  NM_022790.1  NM_022792.2  

    Unigene Cluster for MMP19:

    Matrix metallopeptidase 19
    Hs.591033  [show with all ESTs]
    Unigene Representative Sequence: NR_073606
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548882(uc001sia.3 uc001sib.3 uc001sid.3 uc010spw.2)
    ENST00000547685 ENST00000322569 ENST00000552872 ENST00000548629 ENST00000409200
    ENST00000552763 ENST00000547487 ENST00000547299 ENST00000394182
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MMP19 (see all 23):
    hsa-miR-320a hsa-miR-1321 hsa-miR-193a-3p hsa-miR-431 hsa-miR-1285 hsa-miR-513c hsa-miR-3154 hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmidMMP19 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MMP19
      QuantiFast Probe-based Assays in human, mouse, rat MMP19

    Additional mRNA sequence: 

    AK225939.1 AK303202.1 BC050368.1 NR_073606.1 U37791.1 U38321.1 U38431.1 X92521.1 
    Y08622.1 

    13 DOTS entries:

    DT.102838718  DT.91768200  DT.95264149  DT.86840499  DT.75126070  DT.121194776  DT.100025194  DT.100784521 
    DT.91768198  DT.121194793  DT.121194788  DT.91768208  DT.91862367 

    Selected AceView cDNA sequences (see all 105):

    AA838485 CD742845 BE467000 AI619886 AL548972 CA445889 AW190715 AA778742 
    CB528762 U38431 AI361112 AA586829 AA703579 U38321 BU679694 AI682896 
    NM_022792 CD368816 CK819809 BU688502 CA309794 BM819910 BM141974 CD369488 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MMP19 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                      -                                   -                             -     -                           
    SP2:                                      -     -                             -                                                               
    SP3:                                      -                                   -                                                               
    SP4:                                      -                       -           -                                                               
    SP5:                                      -     -     -     -     -     -     -                             -     -                           


    ECgene alternative splicing isoforms for MMP19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATAAAAA
    MMP19 Expression
    About this image


    MMP19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Thyroid (Endocrine System)
     
     Gall Bladder (Hepatobiliary System)
    MMP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591033

    UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542
    Tissue specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus,
    prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also
    expressed in the synovial fluid of normal and rheumatoid patients

        Custom PCR Arrays for MMP19
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP19
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP19 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp191 , 5 matrix metallopeptidase 191, 5 82.31(n)1
    79.21(a)1
      10 (77.16 cM)5
    582231  NM_021412.21  NP_067387.11 
     1287909535 
    chicken
    (Gallus gallus)
    Aves MMP196
    matrix metallopeptidase 19
    35(a)
    1 ↔ 1
    19(4371005-4377836)
    lizard
    (Anolis carolinensis)
    Reptilia MMP196
    matrix metallopeptidase 19
    59(a)
    1 ↔ 1
    GL343198.1(3155987-3180044)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp191 matrix metallopeptidase 19 62.4(n)
    63.17(a)
      100127631  XM_002934511.2  XP_002934557.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005368741 matrix metalloproteinase-19-like 58.13(n)
    55.12(a)
      100536874  XM_003199413.2  XP_003199461.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T21D11.16
    Protein T21D11.1 (T21D11.1) mRNA, complete cds
    28(a)
    1 → many
    III(7245482-7247784) WBGene00020646


    ENSEMBL Gene Tree for MMP19 (if available)
    TreeFam Gene Tree for MMP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP19 gene
    MMP212  MMP23B2  MMP92  MMP22  MMP262  ELSPBP12  
    9 SIMAP similar genes for MMP19 using alignment to 5 protein entries:     MMP19_HUMAN (see all proteins):
    MMP7    MMP26    MMP10    MMP11    MMP17    mmp20
    MMP13    MMP24    MMP27

    MMP19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP19 (see all 287)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425731301,2
    --56062637(+) TGTACA/CCCTCA 3 -- ds50010--------
    rs1465054721,2
    C--56062639(+) TACCCC/GTCACC 3 -- ds50010--------
    rs1850314661,2
    --56062817(+) CTTTGA/TAGGGA 3 -- ds50010--------
    rs118348571,2
    C,F,H--56063203(+) gtgatC/Actcct 3 -- ut31 nc-transcript-variantese34Minor allele frequency- A:0.02NA NS 186
    rs1899285161,2
    --56063295(+) CTCACA/GGTGGT 3 -- ut31 nc-transcript-variant0--------
    rs32089451,2
    C--56063403(+) CCCAAC/TCTCCA 3 -- ut31 nc-transcript-variantese33Minor allele frequency- T:0.00MN NA 188
    rs178448081,2
    C,F--56063590(-) GAAGG-/GCAGGT 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.02NS 164
    rs760373001,2
    C,F--56063804(+) TCCTGC/TGCAGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.03EA 120
    rs1404249201,2
    C--56063974(+) CTCTGC/TACCCC 3 -- ut31 nc-transcript-variant0--------
    rs2021541071,2
    C--56063985(+) AAAAC-/AAAGAGC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for MMP19 (56229214 - 56236750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832423CNV Gain17160897

    Human Gene Mutation Database (HGMD): MMP19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP19
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601807    OMIM disorders: --

    UniProtKB/Swiss-Prot: MMP19_HUMAN, Q99542
  • Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated
    joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients

  • Selected diseases for MMP19 (see all 32):    
    About MalaCards
    encephalomyelitis    relapsing-remitting multiple sclerosis    keratoacanthoma    thoracic aortic aneurysm
    arthritis    chordoma    multiple sclerosis    keloids
    cerebral amyloid angiopathy    aortic aneurysm    psoriasis    purpura
    chondrosarcoma    graft versus host disease    nasopharyngitis    malignant glioma
    rheumatoid arthritis    ischemia    obesity    cerebritis


    MMP19 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MMP19 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    squamous cell cancer 53.3 2 15868410 (1)
    skin cancer 32.7 2 12516088 (1), 15169894 (1)
    invasive cancer 32.2 1 14694517 (1)
    neovascularization 30.4 1 9232430 (1)
    rheumatoid arthritis 27.2 5 9232430 (1), 15169894 (1), 9562866 (1), 10388526 (1)
    multiple sclerosis 21.6 1 17083473 (1)
    tumors 17.7 20 18161657 (3), 17980449 (2), 20142769 (2), 16707448 (2) (see all 10)
    psoriasis 11.8 3 12735638 (2), 14708597 (1)
    cancer 9.85 6 12516088 (2), 18651563 (1), 15169894 (1), 18286480 (1)
    inflammation 5.38 2 10388526 (1)

    Genetic Association Database (GAD): MMP19
    Human Genome Epidemiology (HuGE) Navigator: MMP19 (8 documents)

    Export disorders for MMP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP19 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with MMP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient. (PubMed id 9232430)1, 2, 3, 9 Kolb C.... Sedlacek R. (Immunol. Lett. 1997)
    2. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. (PubMed id 10809722)1, 2, 9 Stracke J.O.... Knaeuper V. (J. Biol. Chem. 2000)
    3. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution. (PubMed id 9020145)1, 2, 9 Pendas A.M.... Lopez-Otin C. (J. Biol. Chem. 1997)
    4. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). (PubMed id 10922468)1, 2, 9 Stracke J.O.... Knaeuper V. (FEBS Lett. 2000)
    5. Identification of MMP-18, a putative novel human matrix metalloproteinase. (PubMed id 8920941)1, 2, 9 Cossins J.... Clements J.M. (Biochem. Biophys. Res. Commun. 1996)
    6. Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis. (PubMed id 9562866)1, 2, 9 Sedlacek R.... Krawinkel U. (Immunobiology 1998)
    7. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4327 HGNC: 7165 AceView: MMP19 Ensembl:ENSG00000123342 euGenes: HUgn4327
    ECgene: MMP19 H-InvDB: MMP19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP19 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp19/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP19 gene:
    Search GeneIP for patents involving MMP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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