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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP17 Gene

protein-coding   GIFtS: 66
GCID: GC12P132312

Matrix Metallopeptidase 17 (Membrane-Inserted)

(Previous name: matrix metalloproteinase 17 (membrane-inserted))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 17 (Membrane-Inserted)1 2     MT4MMP2 3
Matrix Metalloproteinase 17 (Membrane-Inserted)1 2     MTMMP42 3
Membrane-Type Matrix Metalloproteinase 42 3     MT-MMP 42 3
Membrane-Type-4 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-172
MMP-172 3     EC 3.4.24.-3
MT4-MMP2 3     

External Ids:    HGNC: 71631   Entrez Gene: 43262   Ensembl: ENSG000001985987   OMIM: 6022855   UniProtKB: Q9ULZ93   

Export aliases for MMP17 gene to outside databases

Previous GC identifers: GC12U990053 GC12P131752 GC12P132193 GC12P130807 GC12P130979 GC12P130878 GC12P129198


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP17 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of
the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a
GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MMP17 Gene: 
MMP17 (matrix metallopeptidase 17 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP17 include arthritis, and encephalomyelitis, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and Degradation of collagen. GO annotations related to this gene include enzyme activator activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be
involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as
tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically
activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin,
decorin nor alpha1-antitrypsin

summary for MMP17 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP17 gene promoter:
         CHOP-10   RFX1   Sp1   AP-1   Zic1   HSF1short   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MMP17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.3

MMP17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP17 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132312:  view genomic region     (about GC identifiers)

Start:
132,312,938 bp from pter      End:
132,336,328 bp from pter
Size:
23,391 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9 (See protein sequence)
Recommended Name: Matrix metalloproteinase-17 precursor  
Size: 603 amino acids; 66653 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted,
extracellular space, extracellular matrix
Secondary accessions: Q14850
Alternative splicing: 2 isoforms:  Q9ULZ9-1   Q9ULZ9-2   

Explore the universe of human proteins at neXtProt for MMP17: NX_Q9ULZ9

Explore proteomics data for MMP17 at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by a furin endopeptidase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULZ9

  • MMP17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MMP17 Protein Expression
    REFSEQ proteins: NP_057239.4  
    ENSEMBL proteins: 
     ENSP00000353767   ENSP00000444603   ENSP00000441710   ENSP00000441106   ENSP00000442104  
     ENSP00000443727   ENSP00000439542   ENSP00000445620  
    Reactome Protein details: Q9ULZ9
    Human Recombinant Protein Products for MMP17: 
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    Enzo Life Sciences proteins for MMP17
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
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    Novus Biologicals MMP17 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP17 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005887integral to plasma membrane TAS8640782
    GO:0031012extracellular matrix ----
    GO:0031225anchored to membrane IEA--

    MMP17 for ontologies           About GeneDecksing



    MMP17 Antibody Products: 
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    Abcam antibodies for MMP17
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    LSBio Antibodies in human, mouse, rat for MMP17 

    Assay Products for MMP17: 
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    Cloud-Clone Corp. ELISAs for MMP17 
    Cloud-Clone Corp. CLIAs for MMP17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP17 
    Cell-surface protein and extracellular matrix metalloproteinases

    5/8 InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat
     IPR006026 Peptidase_Metallo

    Graphical View of Domain Structure for InterPro Entry Q9ULZ9

    ProtoNet protein and cluster: Q9ULZ9

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP17_HUMAN, Q9ULZ9
    Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be
    involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as
    tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically
    activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin,
    decorin nor alpha1-antitrypsin
    Catalytic activity: Cleaves pro-TNF-alpha at the 74-Ala- -Gln-75 site

         Genatlas biochemistry entry for MMP17:
    membrane type 4-matrix metalloproteinase 17,mainly predominantly expressed in brain and
    leukocytes,colon,ovary,testis,linked to D12S367,with one minor non expressed transcript and a major alternatively
    spliced,involved in neurogenesis

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS8640782
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP17 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp17):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  normal 
     renal/urinary system  reproductive system 

    MMP17 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MMP17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MMP17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP17 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP17
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP17:
    hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidMMP17 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MMP17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    3Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    4Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MMP17
        Metalloproteases in connective tissue degradation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MMP17
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for MMP17
        Matrix Metalloproteinases

    3        Reactome Pathways for MMP17
        Extracellular matrix organization
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases



    MMP17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP17

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/9 Interacting proteins for MMP17 (Q9ULZ93 ENSP000003537674) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0043085positive regulation of catalytic activity TAS8640782

    MMP17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for MMP17:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP17 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP17    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    Search CenterWatch for drugs/clinical trials and news about MMP17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MMP17 gene: 
    NM_016155.4  

    Unigene Cluster for MMP17:

    Matrix metallopeptidase 17 (membrane-inserted)
    Hs.709245  [show with all ESTs]
    Unigene Representative Sequence: BC045610
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360564(uc001ujc.1) ENST00000545671 ENST00000545790 ENST00000535291(uc001ujd.1)
    ENST00000534865 ENST00000535182 ENST00000542142 ENST00000537848 ENST00000542648
    ENST00000535004 ENST00000535271
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP17:
    hsa-miR-3909
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB021225.2 BC040507.1 BC045610.1 X89576.1 

    5 DOTS entries:

    DT.97857878  DT.408595  DT.91959848  DT.91708742  DT.100664057 

    24/37 AceView cDNA sequences (see all 37):

    BU179230 BQ680344 X89576 BQ227546 AI760347 NM_016155 AL119881 BF514267 
    BU167886 AB021225 BQ678947 BG251251 BC040507 BF347731 BM015637 BX389435 
    BC045610 BM083678 BG478782 BQ638867 AI539031 BE281640 BG768359 BX375177 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MMP17 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:              -                                               -     -     -                                                   
    SP2:                                                              -     -     -                                                   
    SP3:                                                                    -     -                                                   
    SP4:                                                                                                  -                           
    SP5:              -     -                                                                                                         


    ECgene alternative splicing isoforms for MMP17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP17 expression in normal human tissues (normalized intensities)      MMP17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCTCCCT
    MMP17 Expression
    About this image


    MMP17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
             spinal cord/lateral wall/mantle layer   
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Blood (Hematopoietic System)
             reticulocytes   

    See MMP17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP17

    SOURCE GeneReport for Unigene cluster: Hs.709245

    UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
    Tissue specificity: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many
    transformed and non-transformed cell types

        SABiosciences Custom PCR Arrays for MMP17
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MMP17 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp171 , 5 matrix metallopeptidase 171, 5 83.51(n)1
    89.07(a)1
      5 (68.18 cM)5
    239481  NM_011846.41  NP_035976.31 
     1295841695 
    chicken
    (Gallus gallus)
    Aves MMP171 matrix metallopeptidase 17 (membrane-inserted) 75.82(n)
    80.59(a)
      416801  XM_415092.3  XP_415092.2 
    lizard
    (Anolis carolinensis)
    Reptilia MMP176
    --
    Uncharacterized protein
    74(a)
    47(a)
    1 ↔ 1
    possible ortholog
    GL343364.1(84687-96763)
    GL343238.1(212068-227725)
    zebrafish
    (Danio rerio)
    Actinopterygii mmp17a1 matrix metallopeptidase 17a 68.7(n)
    70.98(a)
      570076  XM_693509.5  XP_698601.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp21 , 3 oogenesis metalloendopeptidase3
    Matrix metalloproteinase 21
    40(a)
    (best of 2)3
    51.41(n)1
    41.77(a)1
      359971  NM_206066.21  NP_995788.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C31B8.83
    zmp-11
    Protein ZMP-11 38(a)3
    41.28(n)1
    30.5(a)1
      V(2905685-2909407)3
    1758391  NM_171138.11  NP_741156.11 


    ENSEMBL Gene Tree for MMP17 (if available)
    TreeFam Gene Tree for MMP17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP17 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP112  MMP272  MMP102  MMP12  
    18 SIMAP similar genes for MMP17 using alignment to 9 protein entries:     MMP17_HUMAN (see all proteins):
    mmp20    MMP7    MMP25    MMP26    MMP3    MMP2
    MMP16    MMP24    MMP14    MMP11    MMP10    MMP1
    MMP13    MMP15    MMP8    MMP20    MMP12    MMP19

    MMP17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/702 SNPs in MMP17 are shown (see all 702)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107517051,2
    C,H--129222031(+) GCTTTG/CTAGCG 1 -- ut3116Minor allele frequency- C:0.00NS EA NA WA CSA 665
    rs1437731551,2
    --132311263(+) CCGCGC/TTCTGA 1 -- us2k10--------
    rs1119613021,2
    F--132311330(+) CCACCG/ATTTCC 1 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs777587871,2
    C--132311377(+) AGCCGA/CTTTGG 1 -- us2k10--------
    rs1160384971,2
    C,F--132311435(+) AATCCC/TGGATG 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs734860891,2
    C,F--132311436(+) ATCCCG/TGATGA 1 -- us2k13Minor allele frequency- T:0.06WA NA 240
    rs1150166941,2
    F--132311451(+) AGGTGC/TGGTGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs557386401,2
    C--132311552(+) AACCCC/TGTCTC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1420940071,2
    C--132311586(+) GGGCAC/TGGTTG 1 -- us2k10--------
    rs1511728641,2
    --132311597(+) TGCACA/GCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MMP17 (132312938 - 132336328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MMP17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746902CNV Deletion23290073
    esv2746901CNV Deletion23290073
    nsv899685CNV Loss21882294
    nsv455804CNV Loss19166990
    dgv1516n71CNV Loss21882294
    nsv832555CNV Loss17160897
    esv2751042CNV Gain17911159
    nsv826561CNV Gain20364138
    nsv899699CNV Gain21882294
    nsv455803CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602285    OMIM disorders: --

    13 diseases for MMP17:    About MalaCards
    arthritis    encephalomyelitis    migraine without aura    scoliosis
    migraine    hepatitis c    multiple sclerosis    hypoxia
    rheumatoid arthritis    breast cancer    hepatitis    endotheliitis
    prostatitis


    MMP17 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for MMP17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 34.3 2 16707440 (1), 8640782 (1)
    metastasis 17.2 13 19426156 (4), 16707440 (3), 20019845 (2), 16010555 (1)
    arthritis 13.6 1 10857781 (1)
    breast cancer 4.36 3 16707440 (2), 8640782 (1)
    necrosis 0.788 3 10799478 (1), 8640782 (1)
    tumors 0 8 8640782 (2), 20019845 (2), 10799478 (1), 16010555 (1) (see all 5)
    cancer 0 8 20019845 (4), 10471807 (1), 16707440 (1)

    Genetic Association Database (GAD): MMP17
    Human Genome Epidemiology (HuGE) Navigator: MMP17 (4 documents)

    Export disorders for MMP17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP17 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with MMP17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. (PubMed id 10567400)1, 2, 9 Itoh Y.... Seiki M. (1999)
    2. Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. (PubMed id 10471807)1, 2, 9 Kajita M....Seiki M. (1999)
    3. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. (PubMed id 8640782)1, 2, 9 Puente X.S.... Lopez-Otin C. (1996)
    4. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. (PubMed id 9878265)1, 3, 9 Puente X.S....Lopez-Otin C. (1998)
    5. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    6. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    7. Interferon gamma receptor 2 gene variants are associa ted with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (2010)
    8. Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase. (PubMed id 10543448)1, 2 Kolkenbrock H.... Will H. (1999)
    9. Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. (PubMed id 10551873)1, 2 Wang Y.... Dyer R.D. (1999)
    10. Regulation of membrane-type 4 matrix metalloproteinas e by SLUG contributes to hypoxia-mediated metastasis. (PubMed id 20019845)1, 9 Huang C.H....Yang M.H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4326 HGNC: 7163 AceView: MMP17 Ensembl:ENSG00000198598 euGenes: HUgn4326
    ECgene: MMP17 H-InvDB: MMP17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MMP17 gene:
    Search GeneIP for patents involving MMP17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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