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MMP17 Gene

protein-coding   GIFtS: 64
GCID: GC12P132312

Matrix Metallopeptidase 17 (Membrane-Inserted)

(Previous name: matrix metalloproteinase 17 (membrane-inserted))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 17 (Membrane-Inserted)1 2     MT4MMP2 3
Matrix Metalloproteinase 17 (Membrane-Inserted)1 2     MTMMP42 3
Membrane-Type Matrix Metalloproteinase 42 3     MT-MMP 42 3
Membrane-Type-4 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-172
MMP-172 3     EC 3.4.24.-3
MT4-MMP2 3     

External Ids:    HGNC: 71631   Entrez Gene: 43262   Ensembl: ENSG000001985987   OMIM: 6022855   UniProtKB: Q9ULZ93   

Export aliases for MMP17 gene to outside databases

Previous GC identifers: GC12U990053 GC12P131752 GC12P132193 GC12P130807 GC12P130979 GC12P130878 GC12P129198


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP17 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of
the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a
GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MMP17 Gene:
MMP17 (matrix metallopeptidase 17 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP17 include migraine without aura, and encephalomyelitis. GO annotations related to this gene include enzyme activator activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be
involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as
tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically
activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin,
decorin nor alpha1-antitrypsin

summary for MMP17 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MMP17 gene promoter:
         CHOP-10   RFX1   Sp1   AP-1   Zic1   HSF1short   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MMP17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.3

MMP17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP17 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132312:  view genomic region     (about GC identifiers)

Start:
132,312,938 bp from pter      End:
132,336,328 bp from pter
Size:
23,391 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9 (See protein sequence)
Recommended Name: Matrix metalloproteinase-17 precursor  
Size: 603 amino acids; 66653 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Secondary accessions: Q14850
Alternative splicing: 2 isoforms:  Q9ULZ9-1   Q9ULZ9-2   

Explore the universe of human proteins at neXtProt for MMP17: NX_Q9ULZ9

Explore proteomics data for MMP17 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn137, Asn318
  • Modification sites at PhosphoSitePlus

  • See MMP17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057239.4  
    ENSEMBL proteins: 
     ENSP00000353767   ENSP00000444603   ENSP00000441710   ENSP00000441106   ENSP00000442104  
     ENSP00000443727   ENSP00000439542   ENSP00000445620  
    Reactome Protein details: Q9ULZ9

    MMP17 Human Recombinant Protein Products:

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    MMP17 Assay Products:

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    Cloud-Clone Corp. CLIAs for MMP17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP17
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 9):
     IPR024079 MetalloPept_cat_dom
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018487 Hemopexin-like_repeat
     IPR006026 Peptidase_Metallo

    Graphical View of Domain Structure for InterPro Entry Q9ULZ9

    ProtoNet protein and cluster: Q9ULZ9

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP17_HUMAN, Q9ULZ9
    Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be
    involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as
    tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically
    activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin,
    decorin nor alpha1-antitrypsin
    Catalytic activity: Cleaves pro-TNF-alpha at the 74-Ala- -Gln-75 site

         Genatlas biochemistry entry for MMP17:
    membrane type 4-matrix metalloproteinase 17,mainly predominantly expressed in brain and
    leukocytes,colon,ovary,testis,linked to D12S367,with one minor non expressed transcript and a major alternatively
    spliced,involved in neurogenesis

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS8640782
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP17 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp17):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  normal 
     renal/urinary system  reproductive system 

    MMP17 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP17
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP17

    miRNA
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    miRTarBase miRNAs that target MMP17:
    hsa-mir-335-5p (MIRT018145)

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    1 qRT-PCR Assays for microRNA that regulate MMP17:
    hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidMMP17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MMP17

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP17

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP17_HUMAN, Q9ULZ9: Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted,
    extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005887integral component of plasma membrane TAS8640782
    GO:0031012extracellular matrix ----
    GO:0031225anchored component of membrane IEA--

    MMP17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MMP17
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for MMP17
        Matrix Metalloproteinases

    1 Reactome Pathway for MMP17
        Activation of Matrix Metalloproteinases



    MMP17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMP17
    Interactions:

        GeneGlobe Interaction Network for MMP17

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for MMP17 (Q9ULZ93 ENSP000003537674) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0043085positive regulation of catalytic activity TAS8640782

    MMP17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP17 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP17    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP17    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP17 gene: 
    NM_016155.4  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360564(uc001ujc.1) ENST00000545671 ENST00000545790 ENST00000535291(uc001ujd.1)
    ENST00000534865 ENST00000535182 ENST00000542142 ENST00000537848 ENST00000542648
    ENST00000535004 ENST00000535271
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    1 qRT-PCR Assays for microRNA that regulate MMP17:
    hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidMMP17 3' UTR sequence
    Inhib. RNA
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    Selected AceView cDNA sequences (see all 37):

    BU179230 BQ680344 BC045610 BQ638867 BQ227546 X89576 BM083678 BC040507 
    AI760347 BQ678947 BX389435 NM_016155 AB021225 BG478782 BU167886 BG251251 
    BF514267 BF347731 AL119881 BM015637 BG768359 BE281640 AI829838 BI551593 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MMP17 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:              -                                               -     -     -                                                   
    SP2:                                                              -     -     -                                                   
    SP3:                                                                    -     -                                                   
    SP4:                                                                                                  -                           
    SP5:              -     -                                                                                                         


    ECgene alternative splicing isoforms for MMP17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP17 expression in normal human tissues (normalized intensities)      MMP17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCTCCCT
    MMP17 Expression
    About this image


    MMP17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    MMP17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP17 Protein Expression

    UniProtKB/Swiss-Prot: MMP17_HUMAN, Q9ULZ9
    Tissue specificity: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many
    transformed and non-transformed cell types

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP17 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp171 , 5 matrix metallopeptidase 171, 5 83.66(n)1
    89.22(a)1
      5 (68.18 cM)5
    239481  NM_011846.41  NP_035976.31 
     1295841695 
    chicken
    (Gallus gallus)
    Aves MMP171 matrix metallopeptidase 17 (membrane-inserted) 76.72(n)
    81.82(a)
      416801  XM_415092.4  XP_415092.3 
    lizard
    (Anolis carolinensis)
    Reptilia MMP176
    matrix metallopeptidase 17 (membrane-inserted)
    74(a)
    1 ↔ 1
    GL343364.1(84687-96763)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp171 matrix metallopeptidase 17 (membrane-inserted) 66.92(n)
    73.71(a)
      100125088  NM_001102999.1  NP_001096469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp17a1 matrix metallopeptidase 17a 69.28(n)
    72.08(a)
      570076  XM_693509.6  XP_698601.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp21 , 3 oogenesis metalloendopeptidase3
    Matrix metalloproteinase 21
    40(a)
    (best of 2)3
    51.39(n)1
    41.54(a)1
      359971  NM_206066.31  NP_995788.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C31B8.83
    zmp-11
    zmp-11 38(a)3
    40.98(n)1
    30.5(a)1
      V(2905685-2909407)3
    1758391  NM_171138.21  NP_741156.11 


    ENSEMBL Gene Tree for MMP17 (if available)
    TreeFam Gene Tree for MMP17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP17 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP112  MMP272  MMP102  MMP12  
    18 SIMAP similar genes for MMP17 using alignment to 9 protein entries:     MMP17_HUMAN (see all proteins):
    mmp20    MMP7    MMP25    MMP26    MMP3    MMP2
    MMP16    MMP24    MMP14    MMP11    MMP10    MMP1
    MMP13    MMP15    MMP8    MMP20    MMP12    MMP19

    MMP17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP17 (see all 702)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107517051,2
    C,H--129222031(+) GCTTTG/CTAGCG 1 -- ut3116Minor allele frequency- C:0.00NS EA NA WA CSA 665
    rs1437731551,2
    --132311263(+) CCGCGC/TTCTGA 1 -- us2k10--------
    rs1119613021,2
    F--132311330(+) CCACCG/ATTTCC 1 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs777587871,2
    C--132311377(+) AGCCGA/CTTTGG 1 -- us2k10--------
    rs1160384971,2
    C,F--132311435(+) AATCCC/TGGATG 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs734860891,2
    C,F--132311436(+) ATCCCG/TGATGA 1 -- us2k13Minor allele frequency- T:0.06WA NA 240
    rs1150166941,2
    F--132311451(+) AGGTGC/TGGTGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs557386401,2
    C--132311552(+) AACCCC/TGTCTC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1420940071,2
    C--132311586(+) GGGCAC/TGGTTG 1 -- us2k10--------
    rs1511728641,2
    --132311597(+) TGCACA/GCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MMP17 (132312938 - 132336328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MMP17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746902CNV Deletion23290073
    esv2746901CNV Deletion23290073
    nsv899685CNV Loss21882294
    nsv455804CNV Loss19166990
    dgv1516n71CNV Loss21882294
    nsv832555CNV Loss17160897
    esv2751042CNV Gain17911159
    nsv826561CNV Gain20364138
    nsv899699CNV Gain21882294
    nsv455803CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP17
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602285    OMIM disorders: --

    14 diseases for MMP17:    About MalaCards
    migraine without aura    encephalomyelitis    arthritis    migraine
    hypoxia    hepatitis c    multiple sclerosis    rheumatoid arthritis
    breast cancer    malaria    hepatitis    endotheliitis
    cerebritis    prostatitis


    MMP17 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for MMP17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 34.3 2 16707440 (1), 8640782 (1)
    metastasis 17.2 13 19426156 (4), 16707440 (3), 20019845 (2), 16010555 (1)
    arthritis 13.6 1 10857781 (1)
    breast cancer 4.36 3 16707440 (2), 8640782 (1)
    necrosis 0.788 3 10799478 (1), 8640782 (1)
    tumors 0 8 8640782 (2), 20019845 (2), 10799478 (1), 16010555 (1) (see all 5)
    cancer 0 8 20019845 (4), 10471807 (1), 16707440 (1)

    Genetic Association Database (GAD): MMP17
    Human Genome Epidemiology (HuGE) Navigator: MMP17 (4 documents)

    Export disorders for MMP17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP17 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with MMP17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. (PubMed id 10567400)1, 2, 9 Itoh Y.... Seiki M. (J. Biol. Chem. 1999)
    2. Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. (PubMed id 10471807)1, 2, 9 Kajita M....Seiki M. (FEBS Lett. 1999)
    3. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. (PubMed id 8640782)1, 2, 9 Puente X.S.... Lopez-Otin C. (Cancer Res. 1996)
    4. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. (PubMed id 9878265)1, 3, 9 Puente X.S....LA^pez-OtA-n C. (Genomics 1998)
    5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    8. Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase. (PubMed id 10543448)1, 2 Kolkenbrock H.... Will H. (Biol. Chem. 1999)
    9. Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. (PubMed id 10551873)1, 2 Wang Y.... Dyer R.D. (J. Biol. Chem. 1999)
    10. Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. (PubMed id 20019845)1, 9 Huang C.H....Yang M.H. (Neoplasia 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4326 HGNC: 7163 AceView: MMP17 Ensembl:ENSG00000198598 euGenes: HUgn4326
    ECgene: MMP17 H-InvDB: MMP17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP17 gene:
    Search GeneIP for patents involving MMP17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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