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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP16 Gene

protein-coding   GIFtS: 69
GCID: GC08M089044

matrix metallopeptidase 16 (membrane-inserted)

(Previous names: matrix metalloproteinase 16 (membrane-inserted), chromosome...)
(Previous symbol: C8orf57)
 Explore 46 diseases affiliated with
MMP16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MMP16    

Aliases
for MMP16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Metallopeptidase 16 (Membrane-Inserted)1 2     Chromosome 8 Open Reading Frame 571
MT3-MMP1 2 3     Matrix Metalloproteinase 16 (Membrane-Inserted)1
C8orf571 2     MT-MMP22
Membrane-Type Matrix Metalloproteinase 32 3     MT-MMP32
Membrane-Type-3 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-162
MMP-162 3     Putative Transmembrane Protein C8orf572
MMP-X22 3     EC 3.4.24.-3
MT3MMP2 3     MMPX23
MTMMP32 3     EC 3.4.248
MT-MMP 32 3     EC 3.4.24.808
DKFZp761D1121     

External Ids:    HGNC: 71621   Entrez Gene: 43252   Ensembl: ENSG000001561037   OMIM: 6022625   UniProtKB: P515123   

Export aliases for MMP16 gene to outside databases

Previous GC identifers: GC08M087480 GC08M088781 GC08M089009 GC08M088999 GC08M089118 GC08M084259


Summaries
for MMP16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MMP16:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to
as MT-MMP2, but was renamed as MT-MMP3 or MMP16. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
Function: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and
fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves
fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However,
upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells

summary for MMP16:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP16


Genomic Views
for MMP16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP16 gene promoter:
         Pax-5   Nkx2-2   ITF-2   Tal-1beta   E47   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP16 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21

MMP16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M089044:  view genomic region     (about GC identifiers)

Start:
 89,044,237 bp from pter      End:
 89,340,254 bp from pter
Size:
 296,018 bases      Orientation:
 minus strand

Proteins
for MMP16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512 (See protein sequence)
Recommended Name: Matrix metalloproteinase-16 precursor  
Size: 607 amino acids; 69521 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subunit: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential).
Note=Localized at the cell surface of melanoma cells
Subcellular location: Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized
at the cell surface of melanoma cells
Developmental stage: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain.
Expression seems to decline with advanced development
1 PDB 3D structure from and Proteopedia for MMP16:
1RM8 (3D)    
Secondary accessions: B2RAN7 Q14824 Q52H48
Alternative splicing: 2 isoforms:  P51512-1   P51512-2   

Explore the universe of human proteins at neXtProt for MMP16: NX_P51512

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51512

    • 4/8 DME Specific Peptides for MMP16 (P51512) (see all 8)
     PRCGVPD  PGPGIGGD  AIMAPFYQ  DPGYPKPI 

    MMP16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005932.2  
    ENSEMBL proteins: 
     ENSP00000286614   ENSP00000429147  
    Reactome Protein details: P51512
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MMP16 Protein
    R&D Systems Recombinant & Natural Proteins for MMP16 (MMP-16/MT3-MMP)
    Enzo Life Sciences proteins for MMP16
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): MMP16
    OriGene Custom Protein Services for MMP16 
    GenScript Custom Purified and Recombinant Proteins Services for MMP16
    Novus Biologicals MMP16 Protein
    Novus Biologicals MMP16 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MMP16

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7559440
    GO:0009986cell surface IEA--


    MMP16 for ontologies           About GeneDecksing



    MMP16 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP16
    R&D Systems Antibodies for MMP16 (MMP-16/MT3-MMP)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MMP16 
    GenScript Custom Superior Antibodies Services for MMP16
    Novus Biologicals MMP16 Antibodies
    Abcam antibodies for MMP16 
    Uscn Antibodies for MMP16
    ThermoFisher Antibodies for MMP16

    Assay Products for MMP16: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMP16
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MMP16

    Protein Domains /
    Families
    for MMP16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MMP16 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A_matrixin
     IPR000585 Hemopexin/matrixin
     IPR018486 Hemopexin/matrixin_CS

    Graphical View of Domain Structure for InterPro Entry P51512

    ProtoNet protein and cluster: P51512

    3 Blocks protein families:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin-like domains


    Function
    for MMP16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
    Function: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and
    fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves
    fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However,
    upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells
    Enzyme regulation: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding
    affinity than TIMP-2 for the short isoform

         Genatlas biochemistry entry for MMP16:
    matrix metalloproteinase 16,membrane-type,activator of MMP2,possessing a proteolytic activity against extracellular
    matrix molecules,expressed in placenta,brain and lung

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

    miRNA
    Products:            		miRTarBase miRNAs that target MMP16:
    hsa-mir-146b-5p (MIRT004887), hsa-mir-31 (MIRT004978)

    OriGene 3'-UTR Clone (see all 2): MMP16
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP16
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP16 (see all 94):
    hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-146a hsa-miR-1224-3p hsa-miR-1258 hsa-miR-1260b hsa-miR-3653 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MMP16 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP16 (see all 7)
    OriGene shRNA RFP: MMP16
    OriGene siRNA: MMP16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP16

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MMP16

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP16 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP16 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MMP16 (NM_005941)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP16 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MMP16
    Search LifeMap BioReagents cell lines for MMP16

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP16

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS7559440
    GO:0008270zinc ion binding IEA--


    MMP16 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mmp16tm1Khol for MMP16
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp16):
     craniofacial  digestive/alimentary  growth/size  limbs/digits/tail  mortality/aging 
     normal  skeleton 

    MMP16 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MMP16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Activation of Matrix Metalloproteinases0.40
    2Matrix Metalloproteinases
    		Matrix Metalloproteinases1.00
    		Inhibition of Matrix Metalloproteinases0.68
    3Cell adhesion_ECM remodeling
    		Cell adhesion_ECM remodeling1.00
    		Cell adhesion ECM remodeling1.00
    4MT-MMPs are sorted to the plasma membrane
    		MT-MMPs are sorted to the plasma membrane1.00
    5Collagen formation
    		Extracellular matrix organization0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MMP16
        Cell adhesion ECM remodeling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MMP16
        Inhibition of Matrix Metalloproteinases

    1 GeneGo (Thomson Reuters) Pathway for MMP16
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP16 
        Matrix Metalloproteinases

    4        Reactome Pathways for MMP16
        Extracellular matrix organization
    MT-MMPs are sorted to the plasma membrane
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases



    MMP16 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for MMP16 (P515122, 3 ENSP000002866144) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1Q157263, ENSP000003561624I2D: score=1 STRING: ENSP00000356162
    LRP1Q079543, ENSP000002430774I2D: score=1 STRING: ENSP00000243077
    FURINENSP000002681714STRING: ENSP00000268171
    MMP14ENSP000003082084STRING: ENSP00000308208
    TIMP2ENSP000002627684STRING: ENSP00000262768
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process IEA--
    GO:0043085positive regulation of catalytic activity TAS7559440


    MMP16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MMP16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMP16 for compounds           About GeneDecksing

    EMD Millipore small molecules for MMP16:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP16 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
    PD 166793Broad spectrum MMP inhibitor[199850-67-4]

    1 HMDB Compound for MMP16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for MMP16    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Batimastat-- 130370-60-4target--17139284 17016423 10592235
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    5 Novoseek chemical compound relationships for MMP16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 23.7 1 11757034 (1)
    glycosaminoglycan 23 1 17217338 (1)
    losartan 21.9 6 17273536 (3), 17491697 (3)
    vegf 10.3 2 10037435 (1)
    tyrosine 0 1 19159951 (1)

    Search CenterWatch for drugs/clinical trials and news about MMP16 

    Transcripts
    for MMP16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MMP16 gene (3 alternative transcripts): 
    NM_005941.4  NM_022564.3  NM_032297.1  

    Unigene Cluster for MMP16:

    Matrix metallopeptidase 16 (membrane-inserted)
    Hs.546267  [show with all ESTs]
    Unigene Representative Sequence: NM_005941
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286614(uc003yeb.4) ENST00000544227 ENST00000522726 ENST00000520568


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MMP16
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP16
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP16 (see all 94):
    hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-146a hsa-miR-1224-3p hsa-miR-1258 hsa-miR-1260b hsa-miR-3653 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MMP16 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP16 (see all 7)
    OriGene shRNA RFP: MMP16
    OriGene siRNA: MMP16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP16
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP16 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP16 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: MMP16 (NM_005941)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP16 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP16
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP16

    Additional cDNA sequence: 

    AB009303.1 AK314274.1 AL832595.1 BC069500.1 BC075004.2 BC075005.2 D83646.1 D83647.1 
    D85511.1 U79292.1 

    3 DOTS entries:

    DT.40249016  DT.452470  DT.91699818 

    24/71 AceView cDNA sequences (see all 71):

    AI278525 AI190051 AI192539 BM676913 BX105635 AA599661 F02286 F02205 
    Z46014 BM720811 AU145996 BC075005 Z39369 U79292 F11639 AI207302 
    F13394 CD653853 F03034 BC069500 BM683241 BM992148 BM667517 BM698233 

    GeneLoc Exon Structure


    Expression
    for MMP16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MMP16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    BoneRostral Endochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    CartilageCaudal SynchondrosesCartilage
    CartilageChondrocraniumCartilage
    CartilageRostral ChondrocraniumCartilage
    CartilageRostral SynchondrosesCartilage
    CartilageSynchondrosesCartilage
    Head MesenchymeHead MesenchymeHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MMP16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP16

    SOURCE GeneReport for Unigene cluster: Hs.546267

    UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
    Tissue specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary

        SABiosciences Expression via Pathway-Focused PCR Array including MMP16: 
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    Orthologs
    for MMP16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP16 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MMP161 matrix metallopeptidase 16 (membrane-inserted) 87.07(n)
    92.57(a)    		   396116  NM_205197.1  NP_990528.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MMP166
    		 --
    		 89(a)
    		 1 ↔ 1
    		 4(22127069-22227899)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5720341 matrix metalloproteinase 16 isoform 1 preproprotein-like 71.41(n)
    76.27(a)    		   572034  XM_695689.5  XP_700781.5 
    worm
    (Caenorhabditis elegans)    		 Secernentea C31B8.83   -- 41(a)
    (best of 2)    		   V(2905685-2909407)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G450406
    AT1G599706
    (see all 5)    		 matrix metalloprotease domain-containing protein
    (see all 5)    		 24(a)
    24(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 2(18577650-18578914)
    1(22073534-22074876)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 matrixin family protein
    metalloendoproteinase 1 precursor, putative, expre...
    (see all 4)    		 8(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 10(21890877-21896676)
    2(30974996-30977090)


    ENSEMBL Gene Tree for MMP16 (if available)
    TreeFam Gene Tree for MMP16 (if available) 

    Paralogs
    for MMP16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP16 gene
    MMP132  MMP202  MMP82  MMP142  MMP92  MMP22  MMP252  MMP242  
    MMP152  MMP112  MMP32  MMP272  MMP172  MMP102  MMP12  
    18/19 SIMAP similar genes for MMP16 using alignment to 2 protein entries:     MMP16_HUMAN (see all proteins) (see all similar genes):
    MMP24    MMP14    MMP15    mmp20    MMP17    MMP25
    MMP8    MMP12    MMP3    MMP7    MMP10    MMP11
    MMP20    MMP26    MMP1    MMP13    MMP27    MMP19

    MMP16 for paralogs           About GeneDecksing



    Genomic Variants
    for MMP16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4702 NCBI SNPs in MMP16 are shown (see all 4702)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1868323131,2
    		--89049120(+) ATACTA/GCAATC 1 -- ds50010--------
    rs1920250531,2
    		--89049338(+) GTGTAC/TGTGTA 1 -- ds50010--------
    rs780613951,2
    		C,F,--89049449(+) AGTTTG/AGACAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1831646801,2
    		--89049529(+) TGAAAC/TGGCCA 1 -- ut310--------
    rs26643691,2
    		C,F,O,A,H,--89049531(+) AAATGG/TCCAAA 1 -- ut3129Minor allele frequency- N:0.00EA NA NS WA CSA 4373
    rs1158054681,2
    		F,--89049547(+) TGTTAA/GCAAAA 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1382420791,2
    		--89049735(+) CCTTGC/TCCTCT 1 -- ut310--------
    rs1864460351,2
    		--89049800(+) TCTATA/GACCTT 1 -- ut310--------
    rs1495785071,2
    		--89049912(+) GATGCA/GGAATT 1 -- ut310--------
    rs1896898681,2
    		--89049928(+) TTTACA/GGGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP16 (89044237 - 89294237 bp, first 250kb of MMP16)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for MMP16
         3 CNVs: 95557 3739 65192
         3 Indels: 42238 47593 13084

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    Disorders / Diseases
    for MMP16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MMP16 for disorders           About GeneDecksing

    OMIM gene information: 602262    OMIM disorders: --

    20/46 diseases for MMP16 (see all 46):    About MalaCards
    arthritis    encephalomyelitis    fibrous histiocytoma    malignant fibrous histiocytoma
    idiopathic pulmonary fibrosis    histiocytoma    bronchopulmonary dysplasia    osteochondrosis
    pulmonary fibrosis    papillary thyroid carcinoma    chronic lymphocytic leukemia    seminoma
    lymphocytic leukemia    renal cell carcinoma    nephropathy    thyroid carcinoma
    hepatocellular carcinoma    laryngitis    testicular cancer    rheumatoid arthritis

    10 Novoseek disease relationships for MMP16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 32.7 1 11215209 (1)
    metastasis 32.1 3 15506641 (2), 19397366 (1)
    tumors 21.7 5 12473546 (2), 11293899 (1), 10458406 (1), 10027400 (1)
    carcinoma 16.6 10 17419254 (2), 9927064 (1), 9158005 (1), 10458406 (1)
    diabetic nephropathies 15.9 2 17273536 (1), 17491697 (1)
    glioma 15.2 1 15279711 (1)
    hepatocellular carcinoma 5.74 2 15870919 (1), 17419254 (1)
    cancer 2.27 3 19397366 (1), 20432456 (1), 9685743 (1)
    melanoma 1.46 11 17217338 (3), 11278606 (3), 11525948 (2)
    ovarian cancer 0.254 1 11063654 (1)

    Human Genome Epidemiology (HuGE) Navigator: MMP16 (12 documents)

    Export disorders for MMP16 gene to outside databases

    Publications
    for MMP16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP16 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with MMP16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. (PubMed id 7559440)1, 2, 3, 9 Takino T.... Seiki M. (1995)
    2. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. (PubMed id 9092507)1, 2, 9 Shofuda K.... Miyazaki K. (1997)
    3. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PubMed id 11278606)1, 2, 9 Iida J....McCarthy J.B. (2001)
    4. Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA. (PubMed id 9396633)1, 2, 9 Matsumoto S.... Masuho Y. (1997)
    5. Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features. (PubMed id 14741217)1, 2 Lang R....Maskos K. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Overexpression of MT3-MMP in hepatocellular carcinoma correlates with capsular invasion. (PubMed id 17419254)1, 9 Arai I....Monden M. (2007)
    8. Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). (PubMed id 17217338)1, 9 Iida J....McCarthy J.B. (2007)
    9. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. (PubMed id 18784838)1, 9 Hadchouel A....Delacourt C. (2008)
    10. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PubMed id 9070935)1, 9 Mattei M.G....Apte S.S. (1997)

    External Searches for MMP16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MMP16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4325 HGNC: 7162 AceView: MMP16 Ensembl:ENSG00000156103 euGenes: HUgn4325
    ECgene: MMP16 H-InvDB: MMP16

    Other Databases showing MMP16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MMP16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP16 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp16/

    Intellectual Property
    for MMP16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MMP16 gene:
    Search GeneIP for patents involving MMP16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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