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MMP16 Gene

protein-coding   GIFtS: 71
GCID: GC08M089044

Matrix Metallopeptidase 16 (Membrane-Inserted)

(Previous names: matrix metalloproteinase 16 (membrane-inserted), chromosome...)
(Previous symbol: C8orf57)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 16 (Membrane-Inserted)1 2     Chromosome 8 Open Reading Frame 571
C8orf571 2     Matrix Metalloproteinase 16 (Membrane-Inserted)1
Membrane-Type Matrix Metalloproteinase 32 3     MT-MMP22
Membrane-Type-3 Matrix Metalloproteinase2 3     MT-MMP32
MMP-162 3     Matrix Metalloproteinase-162
MMP-X22 3     Putative Transmembrane Protein C8orf572
MT3-MMP2 3     EC 3.4.24.-3
MT3MMP2 3     MMPX23
MTMMP32 3     EC 3.4.248
MT-MMP 32 3     EC 3.4.24.808

External Ids:    HGNC: 71621   Entrez Gene: 43252   Ensembl: ENSG000001561037   OMIM: 6022625   UniProtKB: P515123   

Export aliases for MMP16 gene to outside databases

Previous GC identifers: GC08M087480 GC08M088781 GC08M089009 GC08M088999 GC08M089118 GC08M084259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP16 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene
was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. (provided by RefSeq, Oct 2010)

GeneCards Summary for MMP16 Gene:
MMP16 (matrix metallopeptidase 16 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP16 include osteochondrosis, and encephalomyelitis. GO annotations related to this gene include enzyme activator activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
Function: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III
and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short
cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V
collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen
by melanoma cells

summary for MMP16 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP16 gene promoter:
         Pax-5   Nkx2-2   ITF-2   Tal-1beta   E47   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP16 promoter sequence
   Search Chromatin IP Primers for MMP16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21

MMP16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M089044:  view genomic region     (about GC identifiers)

Start:
89,044,237 bp from pter      End:
89,340,254 bp from pter
Size:
296,018 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512 (See protein sequence)
Recommended Name: Matrix metalloproteinase-16 precursor  
Size: 607 amino acids; 69521 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subunit: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan
Developmental stage: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in
brain. Expression seems to decline with advanced development
1 PDB 3D structure from and Proteopedia for MMP16:
1RM8 (3D)    
Secondary accessions: B2RAN7 Q14824 Q52H48
Alternative splicing: 2 isoforms:  P51512-1   P51512-2   

Explore the universe of human proteins at neXtProt for MMP16: NX_P51512

Explore proteomics data for MMP16 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn83
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP16 (P51512) (see all 8)
     PRCGVPD  PGPGIGGD  AIMAPFYQ  DPGYPKPI 


    See MMP16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005932.2  
    ENSEMBL proteins: 
     ENSP00000286614   ENSP00000429147  
    Reactome Protein details: P51512

    MMP16 Human Recombinant Protein Products:

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    MMP16 Antibody Products:

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    MMP16 Assay Products:

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    Cloud-Clone Corp. CLIAs for MMP16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP16
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 12):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P51512

    ProtoNet protein and cluster: P51512

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP16_HUMAN, P51512
    Function: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III
    and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short
    cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V
    collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen
    by melanoma cells
    Enzyme regulation: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding
    affinity than TIMP-2 for the short isoform

         Genatlas biochemistry entry for MMP16:
    matrix metalloproteinase 16,membrane-type,activator of MMP2,possessing a proteolytic activity against
    extracellular matrix molecules,expressed in placenta,brain and lung

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008047enzyme activator activity TAS7559440
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP16 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp16):
     craniofacial  digestive/alimentary  growth/size/body  limbs/digits/tail  mortality/aging 
     normal  skeleton 

    MMP16 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp16tm1Khol for MMP16

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP16

    miRNA
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    miRTarBase miRNAs that target MMP16:
    hsa-mir-146b-5p (MIRT004887), hsa-mir-31-5p (MIRT004978)

    Block miRNA regulation of human, mouse, rat MMP16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP16 (see all 94):
    hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-146a hsa-miR-1224-3p hsa-miR-1258 hsa-miR-1260b hsa-miR-3653 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMMP16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP16
    Predesigned siRNA for gene silencing in human, mouse, rat MMP16

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MMP16 (NM_005941)
    Sino Biological Human cDNA Clone for MMP16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP16

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP16_HUMAN, P51512: Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side
    (Potential). Note=Localized at the cell surface of melanoma cells
    MMP16_HUMAN, P51512: Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface.
    Note=Localized at the cell surface of melanoma cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus4
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7559440
    GO:0009986cell surface IEA--

    MMP16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP16 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    4MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MMP16
        Inhibition of Matrix Metalloproteinases

    1 GeneGo (Thomson Reuters) Pathway for MMP16
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP16
        Matrix Metalloproteinases


    1 Reactome Pathway for MMP16
        Activation of Matrix Metalloproteinases


    1 Kegg Pathway  (Kegg details for MMP16):
        MicroRNAs in cancer


    MMP16 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MMP16: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MMP16 (P515122, 3 ENSP000002866144) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1Q157263, ENSP000003561624I2D: score=1 STRING: ENSP00000356162
    LRP1Q079543, ENSP000002430774I2D: score=1 STRING: ENSP00000243077
    FURINENSP000002681714STRING: ENSP00000268171
    MMP14ENSP000003082084STRING: ENSP00000308208
    TIMP2ENSP000002627684STRING: ENSP00000262768
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process IEA--
    GO:0043085positive regulation of catalytic activity TAS7559440

    MMP16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP16 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for MMP16    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Batimastat-- 130370-60-4target--17139284 17016423 10592235
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    5 Novoseek inferred chemical compound relationships for MMP16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 23.7 1 11757034 (1)
    glycosaminoglycan 23 1 17217338 (1)
    losartan 21.9 6 17273536 (3), 17491697 (3)
    vegf 10.3 2 10037435 (1)
    tyrosine 0 1 19159951 (1)



    MMP16 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP16 gene (3 alternative transcripts): 
    NM_005941.4  NM_022564.3  NM_032297.1  

    Unigene Cluster for MMP16:

    Matrix metallopeptidase 16 (membrane-inserted)
    Hs.546267  [show with all ESTs]
    Unigene Representative Sequence: NM_005941
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286614(uc003yeb.4) ENST00000544227 ENST00000522726 ENST00000520568

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      QuantiFast Probe-based Assays in human, mouse, rat MMP16

    Additional mRNA sequence: 

    AB009303.1 AK314274.1 AL832595.1 BC069500.1 BC075004.2 BC075005.2 D83646.1 D83647.1 
    D85511.1 U79292.1 

    3 DOTS entries:

    DT.40249016  DT.452470  DT.91699818 

    Selected AceView cDNA sequences (see all 71):

    BM992148 BM720811 AU145996 AI190051 BM698233 AU119732 BM676913 F02286 
    F02205 BM683241 Z39141 AI139951 F13394 F06768 BC075005 BX105635 
    D85511 BC069500 F03034 AI207302 CA449783 CD653853 U79292 F09293 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCAAAAA
    MMP16 Expression
    About this image


    MMP16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    MMP16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546267

    UniProtKB/Swiss-Prot: MMP16_HUMAN, P51512
    Tissue specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the
    ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including MMP16: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP16 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp161 , 5 matrix metallopeptidase 161, 5 93.19(n)1
    98.02(a)1
      4 (7.08 cM)5
    173891  NM_019724.31  NP_062698.21 
     178528935 
    chicken
    (Gallus gallus)
    Aves MMP161 matrix metallopeptidase 16 (membrane-inserted) 87.07(n)
    92.57(a)
      396116  NM_205197.1  NP_990528.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMP166
    matrix metallopeptidase 16 (membrane-inserted)
    91(a)
    1 ↔ 1
    4(22032016-22227899)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmp161 matrix metallopeptidase 16 (membrane-inserted) 80.61(n)
    87.44(a)
      548746  NM_001015992.3  NP_001015992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp16b1 matrix metallopeptidase 16b (membrane-inserted) 70.11(n)
    74(a)
      572034  XM_695689.6  XP_700781.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp23 oogenesis metalloendopeptidase 46(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for MMP16 (if available)
    TreeFam Gene Tree for MMP16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP16 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP72  MMP242  MMP152  
    MMP32  MMP272  MMP112  MMP172  MMP102  MMP12  
    17 SIMAP similar genes for MMP16 using alignment to 2 protein entries:     MMP16_HUMAN (see all proteins):
    MMP24    MMP14    MMP15    mmp20    MMP17    MMP25
    MMP8    MMP12    MMP3    MMP7    MMP10    MMP11
    MMP20    MMP26    MMP1    MMP13    MMP27

    MMP16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP16 (see all 5395)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862665191,2
    C--84551662(+) TTTTTA/GTAAAA 1 -- us2k10--------
    rs1868323131,2
    --89049120(+) ATACTA/GCAATC 1 -- ds50010--------
    rs1920250531,2
    --89049338(+) GTGTAC/TGTGTA 1 -- ds50010--------
    rs780613951,2
    C,F--89049449(+) AGTTTG/AGACAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1831646801,2
    --89049529(+) TGAAAC/TGGCCA 1 -- ut310--------
    rs26643691,2
    C,F,O,A,H--89049531(+) AAATGG/TCCAAA 1 -- ut3129Minor allele frequency- N:0.00EA NA NS WA CSA 4373
    rs1158054681,2
    C,F--89049547(+) TGTTAA/GCAAAA 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1382420791,2
    --89049735(+) CCTTGC/TCCTCT 1 -- ut310--------
    rs1864460351,2
    --89049800(+) TCTATA/GACCTT 1 -- ut310--------
    rs1495785071,2
    --89049912(+) GATGCA/GGAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP16 (89044237 - 89294237 bp, first 250kb of MMP16)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MMP16 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2188156CNV Deletion18987734
    esv2737276CNV Deletion23290073
    esv1991117CNV Deletion18987734
    esv2669999CNV Deletion23128226
    esv2737275CNV Deletion23290073
    esv2737272CNV Deletion23290073
    esv2671281CNV Deletion23128226
    esv3247CNV Deletion18987735
    esv2737273CNV Deletion23290073
    nsv891170CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602262    OMIM disorders: --

    Selected diseases for MMP16 (see all 41):    
    About MalaCards
    osteochondrosis    encephalomyelitis    arthritis    seminoma
    hypertrophic scars    bronchopulmonary dysplasia    fibrous histiocytoma    histiocytoma
    testicular cancer    diabetic nephropathy    idiopathic pulmonary fibrosis    pulmonary fibrosis
    papillary thyroid carcinoma    laryngitis    sepsis    osteoarthritis
    ovarian cancer    hepatocellular carcinoma    melanoma    chronic lymphocytic leukemia


    MMP16 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for MMP16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 32.7 1 11215209 (1)
    metastasis 32.1 3 15506641 (2), 19397366 (1)
    tumors 21.7 5 12473546 (2), 11293899 (1), 10458406 (1), 10027400 (1)
    carcinoma 16.6 10 17419254 (2), 9927064 (1), 9158005 (1), 10458406 (1)
    diabetic nephropathies 15.9 2 17273536 (1), 17491697 (1)
    glioma 15.2 1 15279711 (1)
    hepatocellular carcinoma 5.74 2 15870919 (1), 17419254 (1)
    cancer 2.27 3 19397366 (1), 20432456 (1), 9685743 (1)
    melanoma 1.46 11 17217338 (3), 11278606 (3), 11525948 (2)
    ovarian cancer 0.254 1 11063654 (1)

    Genetic Association Database (GAD): MMP16
    Human Genome Epidemiology (HuGE) Navigator: MMP16 (12 documents)

    Export disorders for MMP16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP16 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with MMP16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. (PubMed id 7559440)1, 2, 3, 9 Takino T.... Seiki M. (J. Biol. Chem. 1995)
    2. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. (PubMed id 9092507)1, 2, 9 Shofuda K.... Miyazaki K. (J. Biol. Chem. 1997)
    3. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PubMed id 11278606)1, 2, 9 Iida J....McCarthy J.B. (J. Biol. Chem. 2001)
    4. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. (PubMed id 18784838)1, 4, 9 Hadchouel A....Delacourt C. (PLoS ONE 2008)
    5. Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA. (PubMed id 9396633)1, 2, 9 Matsumoto S.... Masuho Y. (Biochim. Biophys. Acta 1997)
    6. Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study. (PubMed id 22417934)1, 4 Athanasiu L....Djurovic S. (Psychiatry Res 2012)
    7. Genome-wide association study identifies five new schizophrenia loci. (PubMed id 21926974)1, 4 (Nat. Genet. 2011)
    8. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. (PubMed id 20207250)1, 4 Davis S.M....Silver R.M. (Am. J. Obstet. Gynecol. 2010)
    9. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    10. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4325 HGNC: 7162 AceView: MMP16 Ensembl:ENSG00000156103 euGenes: HUgn4325
    ECgene: MMP16 Kegg: 4325 H-InvDB: MMP16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP16 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp16/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP16 gene:
    Search GeneIP for patents involving MMP16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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