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Aliases for MMP15 Gene

Aliases for MMP15 Gene

  • Matrix Metallopeptidase 15 2 3 5
  • Matrix Metalloproteinase 15 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 15 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 2 3 4
  • Membrane-Type-2 Matrix Metalloproteinase 3 4
  • MT-MMP 2 3 4
  • MT2-MMP 3 4
  • MMP-15 3 4
  • MT2MMP 3 4
  • MTMMP2 3 4
  • SMCP-2 3 4
  • EC 3.4.24.80 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for MMP15 Gene

Previous GeneCards Identifiers for MMP15 Gene

  • GC16P048455
  • GC16P058144
  • GC16P057793
  • GC16P057834
  • GC16P056616
  • GC16P043926
  • GC16P058060

Summaries for MMP15 Gene

Entrez Gene Summary for MMP15 Gene

  • This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP15 Gene

MMP15 (Matrix Metallopeptidase 15) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP15 Gene

  • Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Tocris Summary for MMP15 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP15 Gene

Genomics for MMP15 Gene

Regulatory Elements for MMP15 Gene

Promoters for MMP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP15 Gene

Chromosome:
16
Start:
58,025,378 bp from pter
End:
58,046,901 bp from pter
Size:
21,524 bases
Orientation:
Plus strand

Genomic View for MMP15 Gene

Genes around MMP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP15 Gene

Proteins for MMP15 Gene

  • Protein details for MMP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51511-MMP15_HUMAN
    Recommended name:
    Matrix metalloproteinase-15
    Protein Accession:
    P51511
    Secondary Accessions:
    • A0A2U6
    • Q14111

    Protein attributes for MMP15 Gene

    Size:
    669 amino acids
    Molecular mass:
    75807 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13071.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MMP15 Gene

Proteomics data for MMP15 Gene at MOPED

Post-translational modifications for MMP15 Gene

Other Protein References for MMP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP15 (MMP-15/MT2-MMP)

Domains & Families for MMP15 Gene

Gene Families for MMP15 Gene

Suggested Antigen Peptide Sequences for MMP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51511

UniProtKB/Swiss-Prot:

MMP15_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP15: view

Function for MMP15 Gene

Molecular function for MMP15 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 15,membrane-type
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP15 Gene

Gene Ontology (GO) - Molecular Function for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP15: view
genes like me logo Genes that share phenotypes with MMP15: view

Animal Models for MMP15 Gene

MGI Knock Outs for MMP15:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP15 Gene

Localization for MMP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP15 Gene

Membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP15 Gene COMPARTMENTS Subcellular localization image for MMP15 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MMP15: view

Pathways & Interactions for MMP15 Gene

genes like me logo Genes that share pathways with MMP15: view

Pathways by source for MMP15 Gene

1 GeneGo (Thomson Reuters) pathway for MMP15 Gene
1 Qiagen pathway for MMP15 Gene

Gene Ontology (GO) - Biological Process for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with MMP15: view

No data available for SIGNOR curated interactions for MMP15 Gene

Drugs & Compounds for MMP15 Gene

(3) Drugs for MMP15 Gene - From: Novoseek, HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
calcium Nutra 0

(4) Additional Compounds for MMP15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP15: view

Transcripts for MMP15 Gene

mRNA/cDNA for MMP15 Gene

Unigene Clusters for MMP15 Gene

Matrix metallopeptidase 15 (membrane-inserted):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP15 Gene

No ASD Table

Relevant External Links for MMP15 Gene

GeneLoc Exon Structure for
MMP15
ECgene alternative splicing isoforms for
MMP15

Expression for MMP15 Gene

mRNA expression in normal human tissues for MMP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP15 Gene

This gene is overexpressed in Liver (x5.2), Colon - Transverse (x4.1), and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for MMP15 Gene

This gene is overexpressed in Placenta (44.1) and Platelet (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMP15 Gene



SOURCE GeneReport for Unigene cluster for MMP15 Gene Hs.80343

mRNA Expression by UniProt/SwissProt for MMP15 Gene

P51511-MMP15_HUMAN
Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with MMP15: view

Protein tissue co-expression partners for MMP15 Gene

Primer Products

In Situ Assay Products

Orthologs for MMP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP15 36
  • 99 (a)
OneToOne
MMP15 35
  • 99.35 (n)
  • 99.55 (a)
cow
(Bos Taurus)
Mammalia MMP15 36
  • 93 (a)
OneToOne
MMP15 35
  • 89.34 (n)
  • 93.27 (a)
dog
(Canis familiaris)
Mammalia MMP15 35
  • 88.94 (n)
  • 92.34 (a)
MMP15 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp15 36
  • 89 (a)
OneToOne
Mmp15 16
Mmp15 35
  • 85.16 (n)
  • 88.72 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP15 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP15 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp15 35
  • 85.88 (n)
  • 89.3 (a)
chicken
(Gallus gallus)
Aves MMP15 35
  • 75.76 (n)
  • 76.24 (a)
MMP15 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP15 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9711 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp15 35
  • 66.56 (n)
  • 69.08 (a)
zebrafish
(Danio rerio)
Actinopterygii MMP15 (1 of 2) 36
  • 65 (a)
OneToMany
mmp15a 36
  • 55 (a)
OneToMany
LOC100332426 35
  • 67.16 (n)
  • 67.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 51 (a)
Mmp2 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
Species with no ortholog for MMP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP15 Gene

ENSEMBL:
Gene Tree for MMP15 (if available)
TreeFam:
Gene Tree for MMP15 (if available)

Paralogs for MMP15 Gene

(12) SIMAP similar genes for MMP15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP15: view

Variants for MMP15 Gene

Sequence variations from dbSNP and Humsavar for MMP15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743563 - 58,045,261(+) AGGAC(A/G)GGGGC reference, missense
rs41340745 - 58,040,033(+) GGTAC(C/T)CTTTG reference, missense
rs41335851 - 58,041,755(+) AAAGC(C/T)GGGCC reference, missense
rs41504346 - 58,045,223(+) GGGGG(A/G)TGGGG reference, missense
rs41434246 - 58,045,300(+) TGGCA(C/T)GGACG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP15 Gene

Variant ID Type Subtype PubMed ID
dgv2875n71 CNV Loss 21882294
nsv906740 CNV Loss 21882294
esv29262 CNV Loss 19812545
nsv906741 CNV Loss 21882294

Variation tolerance for MMP15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP15 Gene

HapMap Linkage Disequilibrium report
MMP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP15 Gene

Disorders for MMP15 Gene

Relevant External Links for MMP15

Genetic Association Database (GAD)
MMP15
Human Genome Epidemiology (HuGE) Navigator
MMP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP15

No disorders were found for MMP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP15 Gene

Publications for MMP15 Gene

  1. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. (PMID: 9119382) Sato H. … Seiki M. (Genomics 1997) 2 3 4 67
  2. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PMID: 9070935) Mattei M.G. … Apte S.S. (Genomics 1997) 2 3 23
  3. TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. (PMID: 16825197) Morrison C.J. … Overall C.M. (J. Biol. Chem. 2006) 3 23
  4. Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. (PMID: 11824946) Hitchon C.A. … Boumpas D.T. (J. Rheumatol. 2002) 3 23
  5. Clinical potential of matrix metalloprotease inhibitors in cancer therapy. (PMID: 10852638) Heath E.I. … Grochow L.B. (Drugs 2000) 25 26

Products for MMP15 Gene

Sources for MMP15 Gene

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