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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MMP15 Gene

protein-coding   GIFtS: 70
GCID: GC16P058060

matrix metallopeptidase 15 (membrane-inserted)

(Previous name: matrix metalloproteinase 15 (membrane-inserted) )
 Explore 37 diseases affiliated with
MMP15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MMP15    

Aliases
for MMP15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Metallopeptidase 15 (Membrane-Inserted)1 2     MMP-152 3
MT2-MMP1 2 3     MT2MMP2 3
MTMMP21 2 3     MT-MMP 22 3
SMCP-21 2 3     Matrix Metalloproteinase-152
Matrix Metalloproteinase 15 (Membrane-Inserted)1 2     EC 3.4.24.-3
Membrane-Type Matrix Metalloproteinase 22 3     EC 3.4.248
Membrane-Type-2 Matrix Metalloproteinase2 3     EC 3.4.24.808

External Ids:    HGNC: 71611   Entrez Gene: 43242   Ensembl: ENSG000001029967   OMIM: 6022615   UniProtKB: P515113   

Export aliases for MMP15 gene to outside databases

Previous GC identifers: GC16P048455 GC16P058144 GC16P057793 GC16P057834 GC16P056616 GC16P043926


Summaries
for MMP15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MMP15:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP
(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these
proteins are expressed at the cell surface rather than secreted. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A

summary for MMP15:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP15


Genomic Views
for MMP15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MMP15 gene promoter:
         STAT1   NF-1   NF-1/L   AML1a   STAT1beta   NF-kappaB   STAT1alpha   GATA-1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MMP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

MMP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058060:  view genomic region     (about GC identifiers)

Start:
 58,059,282 bp from pter      End:
 58,080,805 bp from pter
Size:
 21,524 bases      Orientation:
 plus strand

Proteins
for MMP15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511 (See protein sequence)
Recommended Name: Matrix metalloproteinase-15 precursor  
Size: 669 amino acids; 75807 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein; Extracellular side (Potential)
Sequence caution: Sequence=BAA13071.1; Type=Erroneous initiation;
Secondary accessions: A0A2U6 Q14111

Explore the universe of human proteins at neXtProt for MMP15: NX_P51511

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51511

    • 4/11 DME Specific Peptides for MMP15 (P51511) (see all 11)
     FVFFKGD  PRCGVPD  AIMAPFYQ  RGIQQLYG 

    MMP15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002419.1  
    ENSEMBL proteins: 
     ENSP00000219271   ENSP00000457084  
    Reactome Protein details: P51511
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MMP15 Protein
    R&D Systems Recombinant & Natural Proteins for MMP15 (MMP-15/MT2-MMP)
    Enzo Life Sciences proteins for MMP15
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MMP15
    OriGene Custom Protein Services for MMP15 
    GenScript Custom Purified and Recombinant Proteins Services for MMP15
    Novus Biologicals MMP15 Protein
    Novus Biologicals MMP15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MMP15

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS7649159
    GO:0031012extracellular matrix IEA--


    MMP15 for ontologies           About GeneDecksing



    MMP15 Antibody Products: 
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    R&D Systems Antibodies for MMP15 (MMP-15/MT2-MMP)
    Browse OriGene Antibodies
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    Novus Biologicals MMP15 Antibodies
    Abcam antibodies for MMP15 
    Uscn Antibodies for MMP15
    ThermoFisher Antibodies for MMP15

    Assay Products for MMP15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMP15
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MMP15

    Protein Domains /
    Families
    for MMP15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MMP15 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A_matrixin
     IPR000585 Hemopexin/matrixin
     IPR018486 Hemopexin/matrixin_CS

    Graphical View of Domain Structure for InterPro Entry P51511

    ProtoNet protein and cluster: P51511

    2 Blocks protein families:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin-like domains


    Function
    for MMP15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A

         Genatlas biochemistry entry for MMP15:
    matrix metalloproteinase 15,membrane-type

    Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

    miRNA
    Products:            		miRTarBase miRNAs that target MMP15:
    hsa-mir-29b (MIRT005383), hsa-mir-29c (MIRT005384)

    OriGene 3'-UTR Clone: MMP15
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP15
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP15 (see all 19):
    hsa-miR-148b hsa-miR-1260b hsa-let-7a-2* hsa-miR-624* hsa-miR-144 hsa-miR-9 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: MMP15 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP15 (see all 7)
    OriGene shRNA RFP: MMP15
    OriGene siRNA: MMP15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP15

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MMP15

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP15 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP15
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MMP15 (NM_002428)
    Sino Biological Human cDNA Clone for MMP15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP15 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MMP15
    Search LifeMap BioReagents cell lines for MMP15

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP15

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15248212
    GO:0008047enzyme activator activity TAS7559440
    GO:0008270zinc ion binding IEA--


    MMP15 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MMP15:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-out Mmp15tm1Kohl for MMP15
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp15):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size  mortality/aging 
     normal 

    MMP15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MMP15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Activation of Matrix Metalloproteinases0.40
    		Degradation of collagen0.79
    2Cell adhesion_ECM remodeling
    		Cell adhesion_ECM remodeling1.00
    		Metalloproteases in connective tissue degradation0.31
    		Cell adhesion ECM remodeling1.00
    3Collagen type II degradation by MMP15
    		Collagen type II degradation by MMP151.00
    		Collagen type III degradation by MMP150.33
    4Matrix Metalloproteinases
    		Matrix Metalloproteinases1.00
    		Inhibition of Matrix Metalloproteinases0.68
    5MT-MMPs are sorted to the plasma membrane
    		MT-MMPs are sorted to the plasma membrane1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MMP15
        Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MMP15
        Inhibition of Matrix Metalloproteinases

    1 GeneGo (Thomson Reuters) Pathway for MMP15
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP15 
        Matrix Metalloproteinases

    5/7        Reactome Pathways for MMP15 (see all 7)
        Collagen type III degradation by MMP15
    Collagen type II degradation by MMP15
    Extracellular matrix organization
    MT-MMPs are sorted to the plasma membrane
    Degradation of the extracellular matrix



    MMP15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MMP15 (P515111, 2, 3 ENSP000002192714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PROCP040701, 3, ENSP000002340714EBI-1383043,EBI-1383018 I2D: score=1 STRING: ENSP00000234071
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    --Q9R0642MINT-7897801
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS7559440
    GO:0006508proteolysis IEA--
    GO:0032355response to estradiol stimulus IEA--
    GO:0043085positive regulation of catalytic activity TAS7559440


    MMP15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MMP15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MMP15 for compounds           About GeneDecksing

    EMD Millipore small molecules for MMP15:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MMP15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
    PD 166793Broad spectrum MMP inhibitor[199850-67-4]

    1 HMDB Compound for MMP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    1 Novoseek chemical compound relationship for MMP15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 0 1 12773401 (1)

    Search CenterWatch for drugs/clinical trials and news about MMP15 

    Transcripts
    for MMP15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MMP15 gene: 
    NM_002428.2  

    Unigene Cluster for MMP15:

    Matrix metallopeptidase 15 (membrane-inserted)
    Hs.80343  [show with all ESTs]
    Unigene Representative Sequence: NM_002428
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219271(uc002ena.3) ENST00000570065

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MMP15
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP15
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP15 (see all 19):
    hsa-miR-148b hsa-miR-1260b hsa-let-7a-2* hsa-miR-624* hsa-miR-144 hsa-miR-9 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: MMP15 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP15 (see all 7)
    OriGene shRNA RFP: MMP15
    OriGene siRNA: MMP15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP15
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP15 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MMP15 (NM_002428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP15 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP15

    Additional cDNA sequence: 

    BC006412.1 BC036495.1 BC055428.1 BT006715.1 D85510.1 D86331.1 Z48482.1 

    6 DOTS entries:

    DT.445739  DT.120678318  DT.100721538  DT.99991301  DT.86854977  DT.95265493 

    24/150 AceView cDNA sequences (see all 150):

    AW235381 CR625537 NM_002428 AI335961 BU185089 AW206202 CF139691 BQ691783 
    AW161057 D85510 BQ897926 BG150358 BM759721 BM756734 BM759722 BU145572 
    Z48482 AI286199 CR596713 BM759845 BM783580 CB216669 AI658872 BU160555 

    GeneLoc Exon Structure


    Expression
    for MMP15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCTGAGCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MMP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MMP15

    SOURCE GeneReport for Unigene cluster: Hs.80343

    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine.
    Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including MMP15: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP15
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMP15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP15
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP15

    Orthologs
    for MMP15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MMP15 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MMP151 matrix metallopeptidase 15 (membrane-inserted) 77.62(n)
    79.43(a)    		   415629  XM_413995.3  XP_413995.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MMP156
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL344621.1(17828-27544)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.97112 Xenopus laevis transcribed sequence with weak similarity more 77.17(n)    BJ069397.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003324261 matrix metalloproteinase-15-like 67.41(n)
    67.94(a)    		   100332426  XM_002662908.2  XP_002662954.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea C31B8.83   -- 37(a)   V(2905685-2909407)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G166406
    AT2G450406
    (see all 5)    		 matrix metalloprotease domain-containing protein
    (see all 5)    		 26(a)
    25(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 4(9367248-9368775)
    2(18577650-18578914)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 matrixin family protein
    metalloendoproteinase 1 precursor, putative, expre...
    (see all 4)    		 9(a)
    25(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 10(21890877-21896676)
    2(30974996-30977090)


    ENSEMBL Gene Tree for MMP15 (if available)
    TreeFam Gene Tree for MMP15 (if available) 

    Paralogs
    for MMP15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MMP15 gene
    MMP132  MMP202  MMP82  MMP142  MMP92  MMP162  MMP22  MMP252  
    MMP242  MMP112  MMP32  MMP272  MMP172  MMP102  MMP12  
    14 SIMAP similar genes for MMP15 using alignment to 2 protein entries:     MMP15_HUMAN (see all proteins):
    MMP2    MMP16    MMP14    MMP24    MMP25    MMP8
    MMP17    MMP3    MMP10    MMP11    MMP20    MMP26
    MMP1    MMP12

    MMP15 for paralogs           About GeneDecksing



    Genomic Variants
    for MMP15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 NCBI SNPs in MMP15 are shown (see all 416)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs37599531,2
    		C,F,H,--58057345(+) AAATGA/CGGAAA 1 -- us2k1 tfbs328Minor allele frequency- C:0.08NA NS EA WA 2910
    rs1467473921,2
    		--58057575(+) TGAAAC/TGGTAT 1 -- us2k10--------
    rs1836203041,2
    		--58057596(+) TGGATA/TAGGTT 1 -- us2k10--------
    rs1403495301,2
    		--58057624(+) AGGGCG/TGCAGT 1 -- us2k10--------
    rs20605731,2
    		C,F,O,A,H,--58057627(-) TGAACC/TGCAGC 1 -- us2k138Minor allele frequency- T:0.40NA EA NS WA CSA 4699
    rs414153461,2
    		C,F,--58057743(+) CTCCCA/GAAGTA 1 -- us2k15Minor allele frequency- G:0.01NS 188
    rs1895054951,2
    		--58057822(+) GCAGGA/GTTGGA 1 -- us2k10--------
    rs414154451,2
    		C,--58057939(+) GCCCCT/CTAAAC 1 -- us2k16Minor allele frequency- C:0.02NS NA 294
    rs413420461,2
    		C,--58057950(+) CCCAAC/TTTTTT 1 -- us2k15Minor allele frequency- T:0.01NS 174
    rs354846041,2
    		C--58058362(+) CATTTC/TCCAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MMP15 (58059282 - 58080805 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MMP15
         1 CNV: 67007

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP15
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP15

    Disorders / Diseases
    for MMP15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MMP15 for disorders           About GeneDecksing

    OMIM gene information: 602261    OMIM disorders: --

    20/37 diseases for MMP15 (see all 37):    About MalaCards
    arthritis    encephalomyelitis    adenoid cystic carcinoma    esophageal squamous cell carcinoma
    squamous cell carcinoma    papillary thyroid carcinoma    transitional cell carcinoma    psoriatic arthritis
    chronic cholangitis    adenoiditis    carcinoma    cervical carcinoma
    thyroid carcinoma    hepatocellular carcinoma    prostate cancer    cholangitis
    rheumatoid arthritis    prostate cancer, progression of    hepatitis c    pancreatic cancer

    10/13 Novoseek disease relationships for MMP15 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 39.9 6 16033774 (2), 9708803 (1), 15279711 (1)
    metastasis 33.8 1 9736043 (1)
    glioblastoma 32.2 6 10027400 (4), 9708803 (2)
    carcinoma 25.1 5 9751409 (2), 9927064 (1), 10383907 (1)
    cervical carcinoma 24.1 1 11925127 (1)
    cancer 19.9 7 15739263 (2), 19915148 (2), 9685743 (1), 16093241 (1)
    tumors 19.2 14 10027400 (4), 10383907 (1), 11293899 (1), 9751409 (1) (see all 8)
    pancreatic cancer 12.5 2 10585576 (2)
    hepatocellular carcinoma 10.1 2 15870919 (1), 9736043 (1)
    necrosis 0 2 10531073 (1), 15581686 (1)

    Human Genome Epidemiology (HuGE) Navigator: MMP15 (9 documents)

    Export disorders for MMP15 gene to outside databases

    Publications
    for MMP15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP15 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with MMP15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. (PubMed id 9119382)1, 2, 3 Sato H....Seiki M. (1997)
    2. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PubMed id 9070935)1, 3, 9 Mattei M.G....Apte S.S. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad- spectrum proteolytic capacities comparable to many matrix metalloproteinases. (PubMed id 9461298)1, 2 d'Ortho M.P.... Murphy G. (1997)
    5. cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. (PubMed id 7649159)1, 2 Will H. and Hinzmann B. (1995)
    6. TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. (PubMed id 16825197)1, 9 Morrison C.J. and Overall C.M. (2006)
    7. Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. (PubMed id 11824946)1, 9 Hitchon C.A....Boumpas D.T. (2002)
    8. Matrix metalloproteinases 15 and 19 are stromal regula tors of colorectal cancer development from the early stages. (PubMed id 22576687)1 Sena P....Roncucci L. (2012)
    9. MMP-15 is upregulated in preeclampsia, but does not cl eave endoglin to produce soluble endoglin. (PubMed id 22768148)1 Kaitu'u-Lino T.J....Tong S. (2012)
    10. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1 Soler Artigas M....Tobin M.D. (2011)

    External Searches for MMP15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MMP15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4324 HGNC: 7161 AceView: MMP15 Ensembl:ENSG00000102996 euGenes: HUgn4324
    ECgene: MMP15 H-InvDB: MMP15

    Other Databases showing MMP15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MMP15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MMP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP15 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp15/

    Intellectual Property
    for MMP15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MMP15 gene:
    Search GeneIP for patents involving MMP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MMP15 gene

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    About This Section

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