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Aliases for MMP15 Gene

Aliases for MMP15 Gene

  • Matrix Metallopeptidase 15 (Membrane-Inserted) 2 3
  • Matrix Metalloproteinase 15 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 2 3 4
  • Membrane-Type-2 Matrix Metalloproteinase 3 4
  • MT-MMP 2 3 4
  • MT2-MMP 3 4
  • MMP-15 3 4
  • MT2MMP 3 4
  • MTMMP2 3 4
  • SMCP-2 3 4
  • Matrix Metalloproteinase-15 3
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for MMP15 Gene

Previous GeneCards Identifiers for MMP15 Gene

  • GC16P048455
  • GC16P058144
  • GC16P057793
  • GC16P057834
  • GC16P056616
  • GC16P043926
  • GC16P058060

Summaries for MMP15 Gene

Entrez Gene Summary for MMP15 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP15 Gene

MMP15 (Matrix Metallopeptidase 15 (Membrane-Inserted)) is a Protein Coding gene. Diseases associated with MMP15 include arthritis. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and enzyme activator activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP15 Gene

  • Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Tocris Summary for MMP15 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP15 Gene

Genomics for MMP15 Gene

Regulatory Elements for MMP15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP15 Gene

58,025,378 bp from pter
58,046,901 bp from pter
21,524 bases
Plus strand

Genomic View for MMP15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP15 Gene

Proteins for MMP15 Gene

  • Protein details for MMP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix metalloproteinase-15
    Protein Accession:
    Secondary Accessions:
    • A0A2U6
    • Q14111

    Protein attributes for MMP15 Gene

    669 amino acids
    Molecular mass:
    75807 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=BAA13071.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MMP15 Gene

Proteomics data for MMP15 Gene at MOPED

Post-translational modifications for MMP15 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn150, Thr305, Thr313, Thr318, and Thr320
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP15 (MMP-15/MT2-MMP)

Domains for MMP15 Gene

Suggested Antigen Peptide Sequences for MMP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51511
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP15: view

Function for MMP15 Gene

Molecular function for MMP15 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 15,membrane-type
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP15 Gene

Gene Ontology (GO) - Molecular Function for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15248212
GO:0008047 enzyme activator activity TAS 7559440
GO:0008237 metallopeptidase activity --
genes like me logo Genes that share ontologies with MMP15: view
genes like me logo Genes that share phenotypes with MMP15: view

Animal Models for MMP15 Gene

MGI Knock Outs for MMP15:

Animal Model Products

miRNA for MMP15 Gene

miRTarBase miRNAs that target MMP15

No data available for Transcription Factor Targeting and HOMER Transcription for MMP15 Gene

Localization for MMP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP15 Gene

Membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

Jensen Localization Image for MMP15 Gene COMPARTMENTS Subcellular localization image for MMP15 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP15: view

Pathways for MMP15 Gene

genes like me logo Genes that share pathways with MMP15: view

Pathways by source for MMP15 Gene

1 Qiagen pathway for MMP15 Gene
1 BioSystems pathway for MMP15 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7559440
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with MMP15: view

Compounds for MMP15 Gene

(5) Tocris Compounds for MMP15 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP15 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for MMP15 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
154039-60-8 target inhibitor

(1) Novoseek inferred chemical compound relationships for MMP15 Gene

Compound -log(P) Hits PubMed IDs
progesterone 0 1
genes like me logo Genes that share compounds with MMP15: view

Transcripts for MMP15 Gene

mRNA/cDNA for MMP15 Gene

(7) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP15 Gene

Matrix metallopeptidase 15 (membrane-inserted):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP15 Gene

No ASD Table

Relevant External Links for MMP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP15 Gene

mRNA expression in normal human tissues for MMP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP15 Gene

This gene is overexpressed in Liver (5.2), Colon - Transverse (4.1), and Heart - Left Ventricle (4.0).

Protein differential expression in normal tissues for MMP15 Gene

This gene is overexpressed in Placenta (44.1) and Platelet (17.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMP15 Gene

SOURCE GeneReport for Unigene cluster for MMP15 Gene Hs.80343

mRNA Expression by UniProt/SwissProt for MMP15 Gene

Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle
genes like me logo Genes that share expressions with MMP15: view

Expression partners for MMP15 Gene

In Situ Assay Products

Orthologs for MMP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MMP15 35
  • 89.34 (n)
  • 93.27 (a)
MMP15 36
  • 93 (a)
(Canis familiaris)
Mammalia MMP15 35
  • 88.94 (n)
  • 92.34 (a)
MMP15 36
  • 88 (a)
(Mus musculus)
Mammalia Mmp15 35
  • 85.16 (n)
  • 88.72 (a)
Mmp15 16
Mmp15 36
  • 89 (a)
(Pan troglodytes)
Mammalia MMP15 35
  • 99.35 (n)
  • 99.55 (a)
MMP15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mmp15 35
  • 85.88 (n)
  • 89.3 (a)
(Monodelphis domestica)
Mammalia MMP15 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MMP15 36
  • 78 (a)
(Gallus gallus)
Aves MMP15 35
  • 75.76 (n)
  • 76.24 (a)
MMP15 36
  • 78 (a)
(Anolis carolinensis)
Reptilia MMP15 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp15 35
  • 66.56 (n)
  • 69.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9711 35
(Danio rerio)
Actinopterygii LOC100332426 35
  • 67.16 (n)
  • 67.16 (a)
MMP15 (1 of 2) 36
  • 65 (a)
mmp15a 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 51 (a)
Mmp2 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for MMP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP15 Gene

Gene Tree for MMP15 (if available)
Gene Tree for MMP15 (if available)

Paralogs for MMP15 Gene

Selected SIMAP similar genes for MMP15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP15: view

Variants for MMP15 Gene

Sequence variations from dbSNP and Humsavar for MMP15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1050779 -- 58,046,311(+) CCTTT(C/G)GGCTT utr-variant-3-prime
rs1050792 -- 58,046,725(+) GGATT(C/T)TGCTG utr-variant-3-prime
rs1122306 -- 58,046,468(-) TCTCT(C/T)CTCCC utr-variant-3-prime
rs1123209 -- 58,044,816(+) TAGTC(A/G)TACCC intron-variant
rs1436426 -- 58,038,666(-) CTTGC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP15 Gene

Variant ID Type Subtype PubMed ID
dgv2875n71 CNV Loss 21882294
nsv906740 CNV Loss 21882294
esv29262 CNV Loss 19812545
nsv906741 CNV Loss 21882294

Relevant External Links for MMP15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP15 Gene

Disorders for MMP15 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MMP15 Gene in MalaCards »

(1) Diseases for MMP15 Gene including...

(13) Novoseek inferred disease relationships for MMP15 Gene

Disease -log(P) Hits PubMed IDs
glioma 39.9 4
metastasis 33.8 1
glioblastoma 32.2 6
carcinoma 25.1 4
cervical carcinoma 24.1 1

Relevant External Links for MMP15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MMP15: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MMP15 Gene

Publications for MMP15 Gene

  1. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PMID: 9070935) Mattei M.G. … Apte S.S. (Genomics 1997) 2 3 23
  2. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. (PMID: 9119382) Sato H. … Seiki M. (Genomics 1997) 2 3 4
  3. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad- spectrum proteolytic capacities comparable to many matrix metalloproteinases. (PMID: 9461298) d'Ortho M.P. … Murphy G. (Eur. J. Biochem. 1997) 3 4
  4. TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. (PMID: 16825197) Morrison C.J. … Overall C.M. (J. Biol. Chem. 2006) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MMP15 Gene

Sources for MMP15 Gene

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