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MMP15 Gene

protein-coding   GIFtS: 59

GC16P058144
matrix metallopeptidase 15 (membrane-inserted)
(Previous name: matrix metalloproteinase 15 (membrane-inserted) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for MMP15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
matrix metallopeptidase 15 (membrane-inserted)1 2     Membrane-type matrix metalloproteinase 22 3
MT2-MMP1 2 3     MT-MMP 22 3
SMCP-21 2 3     MMP-152 3
MTMMP21 2 3     MT2MMP2 3
matrix metalloproteinase 15 (membrane-inserted)1 2     matrix metalloproteinase-152
Membrane-type-2 matrix metalloproteinase2 3     EC 3.4.24.-3

External Ids:    HGNC: 71611   Entrez Gene: 43242   Ensembl: ENSG000001029967   UniProtKB: P515113   

Search outside databases for aliases for MMP15 gene

Previous GC identifers: GC16P048455 GC16P057793 GC16P057834 GC16P056616

Summaries
for MMP15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for MMP15:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated
when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type
MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these
proteins are expressed at the cell surface rather than secreted. (provided by RefSeq)

UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A

"" summary for MMP15:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Genomic Views
for MMP15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the MMP15 gene upstream (promoter) region "":
p53   RP58   GATA-1   Pbx1a   NF-1   Chx10   Lmo2   NF-E2 p45   NF-E2   FOXD3   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for MMP15:  ""
MePH20745-1A   MePH20746-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

MMP15 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058144:  view genomic region     (about GC identifiers)

Start:
 58,059,282 bp from pter
End:
 58,080,805 bp from pter
Size:
 21,524 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

Proteins
for MMP15 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511 (See protein sequence)
Recommended Name: Matrix metalloproteinase-15 precursor  
Size: 669 amino acids; 75807 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein; Extracellular side (Potential)
Sequence caution: Sequence=BAA13071.1; Type=Erroneous initiation;
Secondary accessions: A0A2U6 Q14111

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002419.1  

    ENSEMBL proteins: 
    ENSP00000219271 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant MMP15 Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""Browse Abnova for HuPro® and/or Recombinant Proteins
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    Novus Biologicals Lysate for MMP15
    ""Browse Sino Biological Recombinant Proteins  ""

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578 proteinaceous extracellular matrix ----
    GO:0005887 integral to plasma membrane TAS7649159
    GO:0016020 membrane IEA--
    GO:0031012 extracellular matrix IEA--
    About this table

    "" MMP15 for ontologies           About GeneDecksing



    Antibodies for MMP15: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of MMP15
    ""Sigma-Aldrich Antibodies for MMP15
    ""R&D Systems Antibodies for MMP15 (MMP-15)
    ""Monoclonal and Polyclonal Antibodies from Abnova (MMP15)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for MMP15
    ""Browse antibodies at Epitomics

    Assays for MMP15: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for MMP15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" MMP15 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10 ):
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A_matrix_cons-reg
     IPR000585 Hemopexin/matrixin
     IPR018486 Hemopexin/matrixin_CS
     IPR018487 Hemopexin/matrixin_repeat

    Graphical View of Domain Structure for InterPro Entry P51511

    ProtoNet protein and cluster: P51511

    2 Blocks protein families:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin-like domains

    Gene Function
    for MMP15 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MMP15)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: MMP15
    Origene shRNA RFP: MMP15
    Origene basic RS shRNA: MMP15

    ""Applied Biosystems Silencer® siRNAs for MMP15
    ""Sigma-Aldrich siRNA Panels and siRNA for MMP15
    Sigma-Aldrich shRNA Panels and shRNA for MMP15
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: MMP15
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: MMP15
    Origene untagged cDNA clones in CMV expression vector: MMP15
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Genatlas biochemistry entry for MMP15:
    matrix metalloproteinase 15,membrane-type

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IPI15248212
    GO:0008047 enzyme activator activity TAS7559440
    GO:0008233 peptidase activity IEA--
    About this table

    "" MMP15 for ontologies           About GeneDecksing

    Animal Models: 2 MGI phenotypic alleles "" for Mmp15 (no phenotypes)


    "" MMP15 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for MMP15 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" MMP15 for pathways           About GeneDecksing

    2 "" Millipore Pathways for MMP15
      ""  Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation

    4 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  MMP15  (Your Favorite Gene powered by Ingenuity)
      ""  Colorectal Cancer Metastasis Signaling
    Bladder Cancer Signaling
    HIF1? Signaling
    Leukocyte Extravasation Signaling

    1 "" GeneAssist Pathway for MMP15
      ""  Inhibition of Matrix Metalloproteinases

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP15

    1 Interacting protein for MMP15 (P515111) via UniProtKB, MINT, and/or STRING ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PROCP040701EBI-1383043,EBI-1383018
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464 protein modification process TAS7559440
    GO:0006508 proteolysis IEA--
    GO:0008152 metabolic process IEA--
    About this table

    "" MMP15 for ontologies           About GeneDecksing


    Drugs & Compounds
    for MMP15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" MMP15 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for MMP15
    ""Browse Small Molecules at Sigma-Aldrich

    "" Compounds for MMP15 available from Tocris Bioscience
    CompoundAction CAS number
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]
    BatimastatPotent, broad spectrum MMP inhibitor[130370-60-4]
    PD 166793Broad spectrum MMP inhibitor[199850-67-4]
    About this table


    5 ""Novoseek chemical compound relationships for MMP15 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-nitrosobis(2-oxopropyl)amine 2.35 1 10383907 (1)
    amd3100 2.18 1 16033774 (1)
    gnrh 0.50 1 17201186 (1)
    serine 0.33 1 10673371 (1)
    progesterone 0.14 1 12773401 (1)
    About this table


    Transcripts
    for MMP15 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (MMP15)
    ""Applied Biosystems Silencer® siRNAs:  NM_002428  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: MMP15
    Origene shRNA RFP: MMP15
    Origene basic RS shRNA: MMP15

    ""Sigma-Aldrich siRNA Panels and siRNA for MMP15
    Sigma-Aldrich shRNA Panels and shRNA for MMP15
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""8 SABiosciences microRNAs that regulate MMP15: ""
    hsa-miR-152 hsa-miR-144 hsa-miR-9 hsa-miR-148b hsa-miR-133a hsa-miR-101 hsa-miR-133b hsa-miR-148a
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_002428  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: MMP15
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: MMP15
    Origene untagged cDNA clones in CMV expression vector: MMP15
    Primers:"" Origene genome-wide validated SYBR primer pairs: MMP15
    ""SABiosciences RT2 qPCR Primer Assay for MMP15: PPH00910A ""

    REFSEQ mRNAs for MMP15 gene: 

    NM_002428.2  

    Additional cDNA sequence: 

    BC006412.1 BC036495.1 BC055428.1 BT006715.1 CR596713.1 CR625537.1 D85510.1 D86331.1 
    Z48482.1 

    6 DOTS entries:

    DT.445739  DT.120678318  DT.100721538  DT.99991301  DT.86854977  DT.95265493 

    24/150 AceView cDNA sequences (see all 150 ):

    Z48482 AA704660 BU179939 AW183978 CB216669 AW235381 BG150358 BM759845 
    AI335961 D86331 BC006412 CR625537 BQ691783 BM759722 D85510 BM759721 
    AW161057 BM766813 BM766566 BU145572 BQ897926 AI286199 BM756734 NM_002428 

    "" highest scoring ESTs for MMP15:

    D86331 Z48482 AA091617 AA377749 AA418263 AA418366 AA443300 AA443433 AA620306 AA704660 

    Unigene Cluster for MMP15:

    Matrix metallopeptidase 15 (membrane-inserted)
    Hs.80343  [show with all ESTs]
    Unigene Representative Sequence: NM_002428


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000219271  

    Expression
    for MMP15 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    MMP15 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for MMP15

    1""  / 2""  / 3""

    6 probe-sets matching MMP15 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1167_s_at2, 3 U95-A 1 0.81 1.00 0.43 1.08 D86331 1.00 1.00 1.00 1
    160037_at2, 3 U95-A 1 0.75 1.00 0.98 0.93 Z48482 1.00 1.00 1.00 1
    203365_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_002428 0.60 1.00 0.82 1
    243883_at2, 3 U133-B 1 0.55 1.00 -- -- AI951673 0.60 1.00 0.82 1
    203365_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    243883_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    "" MMP15 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCCTGAGCG

    SOURCE GeneReport for Unigene cluster: Hs.80343

    Expression variation in blood from EXPOLDB for MMP15

    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine.
    Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle

    Primers:"" Origene genome-wide validated SYBR primer pairs: MMP15 ""
    ""SABiosciences RT2 qPCR Primer Assay for MMP15: PPH00910A ""

    Orthologs
    for MMP15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for MMP15 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MMP151   -- matrix metallopeptidase 15 (membrane-inserted) 89.47(n)
    93.46(a)    		 487257  XM_544383.2  XP_544383.2 
    chimpanzee
    (Pan troglodytes)    		 MMP151   -- matrix metallopeptidase 15 (membrane-inserted) 99.15(n)
    99.55(a)    		 467988  XM_523380.2  XP_523380.2 
    cow
    (Bos taurus)    		 MMP151   -- matrix metallopeptidase 15 (membrane-inserted) 89.79(n)
    94.47(a)    		 519432  XM_597651.3  XP_597651.2 
    rat
    (Rattus norvegicus)    		 Mmp151   -- matrix metallopeptidase 15 85.88(n)
    89.45(a)    		 291848  XM_238034.4  XP_238034.4 
    mouse
    (Mus musculus)    		 Mmp151, 5 8 (45.50 cM)5
    		 matrix metallopeptidase 151, 5 85.16(n)1
    88.87(a)1    		 173881  NM_008609.31  NP_032635.11 
     AI5035515  AK0045235  (see all 9)
    About this table        Species with no ortholog for MMP15

    ENSEMBL Gene Tree for MMP15

    Paralogs
    for MMP15 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

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    Paralogs for MMP15 gene
    MMP202  MMP132  MMP82  MMP142  MMP122  MMP22  MMP162  MMP252  
    MMP272  MMP102  MMP12  MMP92  MMP282  MMP192  MMP242  MMP32  
    MMP112  MMP172  

    "" MMP15 for paralogs           About GeneDecksing


    Genomic Variants
    for MMP15 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/204 NCBI SNPs in MMP15 are shown (see all 204 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 52)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs20605731,2
    		C,F,O,A43924761(-) TGAACC/TGCAGC 1 -- ng51""21Minor allele frequency- T:0.45NA EA NS 2938""
    ""
    rs22417731,2
    		C,F,A,H43948045(-) TCCTTG/AGCATT 1 -- ng31""23Minor allele frequency- A:0.31EA NA NS 2480""
    ""
    rs110762131,2
    		C,F,A,H58080009(+) CACCTC/TCTTCC 1 -- ut31 trp3""17Minor allele frequency- T:0.48NS EA NA 1144""
    --
    rs413408501,2
    		C,F,H43948004(+) GTGGGG/TGTCCA 1 -- ng31""5Minor allele frequency- T:0.12NS 190""
    ""
    rs37599551,2
    		C,F,A43925587(+) AGAATT/CGCCCG 1 -- ng51""8Minor allele frequency- C:0.34NS NA EA WA 388""
    --
    rs413996511,2
    		C,F58079852(+) GCCGTG/AGCCCT 1 -- ut31""6Minor allele frequency- A:0.05NS WA 200""
    ""
    rs37599561,2
    		C,F43925598(+) GTTCCC/TTTCTC 1 -- ng51 trp3""7Minor allele frequency- T:0.48NS NA EA 338""
    --
    rs415233441,2
    		C,H58080671(+) CCAAGT/CGCGGG 1 -- ut31""5Minor allele frequency- C:0.00NS 190""
    --
    rs11223061,2
    		C,F58080372(-) TCTCTC/TCTCCC 1 -- ut31 ese3 trp3""10Minor allele frequency- T:0.06NA MN NS 584""
    --
    rs414114461,2
    		C,F58079868(+) CCCCAT/CTGAGG 1 -- ut31""6Minor allele frequency- C:0.03NS NA 226""
    About this table

    HapMap Linkage Disequilibrium images for MMP15 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 1 variation for MMP15
         1 CNV: 67007

    Disorders & Mutations
    for MMP15 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

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    "" MMP15 for disorders           About GeneDecksing

    OMIM: 602261

    10/46 ""Novoseek disease relationships for MMP15 gene (see all 46 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 7.77 6 10027400 (4), 9708803 (2)
    leg ulcer 6.58 4 12452868 (4)
    melanoma metastatic 4.50 3 11525948 (3)
    medulloblastoma 4.02 3 9708803 (3)
    tumor progression 3.97 4 20117087 (4)
    fibrosis liver 3.62 3 15650781 (3)
    astrocytoma 3.52 3 10027400 (3)
    effusion 3.31 3 11293899 (3)
    glioma 2.95 4 16033774 (2), 9708803 (1), 15279711 (1)
    scirrhous carcinoma 2.40 1 15387372 (1)
    About this table

    Medical News
    for MMP15 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback    		   --

    Publications
    for MMP15 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/67 PubMed articles for MMP15 gene (see all 67 ):

    Search for MMP15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing MMP15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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      User Feedback
    Entrez Gene: 4324 HGNC: 7161 AceView: MMP15 Ensembl:ENSG00000102996 euGenes: HUgn4324
    ECgene: MMP15 H-InvDB: MMP15

    Other Databases showing MMP15 gene

    (According to HUGE)
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    Specialized Databases showing MMP15 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for MMP15 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp15/

    Intellectual Property
    for MMP15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for MMP15 gene: ""
    Search GeneIP for patents involving MMP15

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    Services
    for MMP15 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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