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Aliases for MMP15 Gene

Aliases for MMP15 Gene

  • Matrix Metallopeptidase 15 2 3 5
  • Matrix Metalloproteinase 15 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 15 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 2 3 4
  • Membrane-Type-2 Matrix Metalloproteinase 3 4
  • MT-MMP 2 3 4
  • MT2-MMP 3 4
  • MMP-15 3 4
  • MT2MMP 3 4
  • MTMMP2 3 4
  • SMCP-2 3 4
  • Matrix Metalloproteinase-15 3
  • EC 3.4.24.80 61
  • EC 3.4.24.- 4
  • EC 3.4.24 61

External Ids for MMP15 Gene

Previous GeneCards Identifiers for MMP15 Gene

  • GC16P048455
  • GC16P058144
  • GC16P057793
  • GC16P057834
  • GC16P056616
  • GC16P043926
  • GC16P058060

Summaries for MMP15 Gene

Entrez Gene Summary for MMP15 Gene

  • This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP15 Gene

MMP15 (Matrix Metallopeptidase 15) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP14.

UniProtKB/Swiss-Prot for MMP15 Gene

  • Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Tocris Summary for MMP15 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP15 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP15 Gene

Genomics for MMP15 Gene

Regulatory Elements for MMP15 Gene

Enhancers for MMP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G058119 1.4 Ensembl ENCODE dbSUPER 12.1 +95.5 95470 3.4 HDAC1 PKNOX1 SIN3A ARID4B FEZF1 RAD21 TCF12 EGR1 SCRT2 ZNF143 MMP15 CSNK2A2 CNGB1 CFAP20 ENSG00000260545
GH16G058114 0.8 ENCODE dbSUPER 16.4 +90.3 90327 3.3 RFX1 ZMYM3 REST ATF2 NR2F2 MMP15 CSNK2A2 CNGB1 CFAP20 ENSG00000260545 LOC100125393
GH16G058118 0.4 Ensembl 12.1 +93.5 93524 0.2 FOXA2 MMP15 CSNK2A2 CNGB1 ENSG00000260545 CFAP20
GH16G058099 0.8 ENCODE dbSUPER 5.4 +74.4 74406 1.1 RFX1 ZNF341 CEBPA CEBPG PRDM10 EGR2 CNGB1 PRSS54 MMP15 TEPP LOC100125393 ENSG00000260545
GH16G058081 0.7 Ensembl ENCODE 4.9 +56.2 56226 0.4 RFX1 NR2F2 MMP15 ENSG00000207173 GC16M058083 PIR61773
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP15 on UCSC Golden Path with GeneCards custom track

Promoters for MMP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086533 1122 2601 PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 ZNF263

Genomic Location for MMP15 Gene

Chromosome:
16
Start:
58,025,378 bp from pter
End:
58,046,901 bp from pter
Size:
21,524 bases
Orientation:
Plus strand

Genomic View for MMP15 Gene

Genes around MMP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP15 Gene

Proteins for MMP15 Gene

  • Protein details for MMP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51511-MMP15_HUMAN
    Recommended name:
    Matrix metalloproteinase-15
    Protein Accession:
    P51511
    Secondary Accessions:
    • A0A2U6
    • Q14111

    Protein attributes for MMP15 Gene

    Size:
    669 amino acids
    Molecular mass:
    75807 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13071.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MMP15 Gene

Selected DME Specific Peptides for MMP15 Gene

P51511:
  • GGFLAHAYFPGP
  • PGPGLGGD
  • PRCGVPD
  • AIMAPFYQ
  • RGIQQLYG
  • FVFFKGD
  • FYGIPVTGVLD
  • GHALGLEHS
  • RGEMFVFK
  • FASGFHGDSSPFDG
  • DPGYPKPI

Post-translational modifications for MMP15 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=150150 and posLast=313313
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP15 (MMP-15/MT2-MMP)

Domains & Families for MMP15 Gene

Gene Families for MMP15 Gene

Suggested Antigen Peptide Sequences for MMP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51511

UniProtKB/Swiss-Prot:

MMP15_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP15: view

Function for MMP15 Gene

Molecular function for MMP15 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 15,membrane-type
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP15 Gene

Gene Ontology (GO) - Molecular Function for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15248212
GO:0008047 enzyme activator activity TAS 7559440
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MMP15: view
genes like me logo Genes that share phenotypes with MMP15: view

Animal Models for MMP15 Gene

MGI Knock Outs for MMP15:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP15

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP15 Gene

Localization for MMP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP15 Gene

Membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP15 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP15: view

Pathways & Interactions for MMP15 Gene

genes like me logo Genes that share pathways with MMP15: view

Pathways by source for MMP15 Gene

1 GeneGo (Thomson Reuters) pathway for MMP15 Gene
1 Qiagen pathway for MMP15 Gene

Gene Ontology (GO) - Biological Process for MMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7559440
GO:0006508 proteolysis TAS,IEA 14645246
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process TAS --
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with MMP15: view

No data available for SIGNOR curated interactions for MMP15 Gene

Drugs & Compounds for MMP15 Gene

(7) Drugs for MMP15 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0
GM 6001 Pharma Broad spectrum MMP inhibitor 0

(1) Additional Compounds for MMP15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP15 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP15: view

Transcripts for MMP15 Gene

mRNA/cDNA for MMP15 Gene

Unigene Clusters for MMP15 Gene

Matrix metallopeptidase 15 (membrane-inserted):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP15 Gene

No ASD Table

Relevant External Links for MMP15 Gene

GeneLoc Exon Structure for
MMP15
ECgene alternative splicing isoforms for
MMP15

Expression for MMP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP15 Gene

This gene is overexpressed in Liver (x5.2), Colon - Transverse (x4.1), and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for MMP15 Gene

This gene is overexpressed in Placenta (44.1) and Platelet (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MMP15 Gene



Protein tissue co-expression partners for MMP15 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP15 Gene:

MMP15

SOURCE GeneReport for Unigene cluster for MMP15 Gene:

Hs.80343

mRNA Expression by UniProt/SwissProt for MMP15 Gene:

P51511-MMP15_HUMAN
Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for MMP15 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MMP15: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP15 Gene

Orthologs for MMP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP15 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia MMP15 34 35
  • 89.34 (n)
dog
(Canis familiaris)
Mammalia MMP15 34 35
  • 88.94 (n)
rat
(Rattus norvegicus)
Mammalia Mmp15 34
  • 85.88 (n)
mouse
(Mus musculus)
Mammalia Mmp15 34 16 35
  • 85.16 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP15 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP15 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP15 35 34
  • 75.76 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP15 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp15 34
  • 66.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9711 34
zebrafish
(Danio rerio)
Actinopterygii LOC100332426 34
  • 67.16 (n)
MMP15 (1 of 2) 35
  • 65 (a)
OneToMany
mmp15a 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
ManyToMany
Species where no ortholog for MMP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP15 Gene

ENSEMBL:
Gene Tree for MMP15 (if available)
TreeFam:
Gene Tree for MMP15 (if available)

Paralogs for MMP15 Gene

(12) SIMAP similar genes for MMP15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP15: view

Variants for MMP15 Gene

Sequence variations from dbSNP and Humsavar for MMP15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024926 -- 58,025,830(+) TCGCT(C/T)GCTCT utr-variant-5-prime
rs1000070635 -- 58,032,660(+) ATTCA(A/G)CACAG intron-variant
rs1000301917 -- 58,031,640(+) GTCAG(A/G)CCTCA intron-variant
rs1000338266 -- 58,032,983(+) GCTCC(A/G)CAGAT intron-variant
rs1000466740 -- 58,036,674(+) ACTGG(C/G)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP15 Gene

Variant ID Type Subtype PubMed ID
dgv525e214 CNV gain 21293372
esv29262 CNV loss 19812545
esv3638716 CNV loss 21293372
nsv1063386 CNV gain 25217958
nsv572759 CNV loss 21841781
nsv572760 CNV loss 21841781
nsv572761 CNV loss 21841781
nsv572762 CNV loss 21841781

Variation tolerance for MMP15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP15 Gene

Disorders for MMP15 Gene

Relevant External Links for MMP15

Genetic Association Database (GAD)
MMP15
Human Genome Epidemiology (HuGE) Navigator
MMP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP15

No disorders were found for MMP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP15 Gene

Publications for MMP15 Gene

  1. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PMID: 9070935) Mattei M.G. … Apte S.S. (Genomics 1997) 2 3 22 64
  2. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. (PMID: 9119382) Sato H. … Seiki M. (Genomics 1997) 2 3 4 64
  3. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 46 64
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B. … Abel L. (Gut 2010) 3 46 64

Products for MMP15 Gene

Sources for MMP15 Gene

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