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MMP15 Gene

protein-coding   GIFtS: 73
GCID: GC16P058060

Matrix Metallopeptidase 15 (Membrane-Inserted)

(Previous name: matrix metalloproteinase 15 (membrane-inserted))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 15 (Membrane-Inserted)1 2     MTMMP22 3
Matrix Metalloproteinase 15 (Membrane-Inserted)1 2     SMCP-22 3
Membrane-Type Matrix Metalloproteinase 22 3     MT-MMP 22 3
Membrane-Type-2 Matrix Metalloproteinase2 3     Matrix Metalloproteinase-152
MMP-152 3     EC 3.4.24.-3
MT2-MMP2 3     EC 3.4.248
MT2MMP2 3     EC 3.4.24.808

External Ids:    HGNC: 71611   Entrez Gene: 43242   Ensembl: ENSG000001029967   OMIM: 6022615   UniProtKB: P515113   

Export aliases for MMP15 gene to outside databases

Previous GC identifers: GC16P048455 GC16P058144 GC16P057793 GC16P057834 GC16P056616 GC16P043926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP15 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the
membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain
suggesting that these proteins are expressed at the cell surface rather than secreted. (provided by RefSeq, Jul
2008)

GeneCards Summary for MMP15 Gene:
MMP15 (matrix metallopeptidase 15 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP15 include chronic cholangitis, and adenoid cystic carcinoma. GO annotations related to this gene include enzyme activator activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A

summary for MMP15 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP15 gene promoter:
         STAT1   NF-1   NF-1/L   AML1a   STAT1beta   NF-kappaB   STAT1alpha   GATA-1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP15 promoter sequence
   Search Chromatin IP Primers for MMP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

MMP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058060:  view genomic region     (about GC identifiers)

Start:
58,059,282 bp from pter      End:
58,080,805 bp from pter
Size:
21,524 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511 (See protein sequence)
Recommended Name: Matrix metalloproteinase-15 precursor  
Size: 669 amino acids; 75807 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Sequence caution: Sequence=BAA13071.1; Type=Erroneous initiation;
Secondary accessions: A0A2U6 Q14111

Explore the universe of human proteins at neXtProt for MMP15: NX_P51511

Explore proteomics data for MMP15 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn150, Thr305, Thr313, Thr318, Thr320
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP15 (P51511) (see all 11)
     FVFFKGD  PRCGVPD  AIMAPFYQ  RGIQQLYG 


    See MMP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002419.1  
    ENSEMBL proteins: 
     ENSP00000219271   ENSP00000457084  
    Reactome Protein details: P51511

    MMP15 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    MMP15 Antibody Products:

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    MMP15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MMP15
    Cloud-Clone Corp. CLIAs for MMP15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP15
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 12):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P51511

    ProtoNet protein and cluster: P51511

    2 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP15_HUMAN, P51511
    Function: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A

         Genatlas biochemistry entry for MMP15:
    matrix metalloproteinase 15,membrane-type

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.802 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15248212
    GO:0008047enzyme activator activity TAS7559440
    GO:0008237metallopeptidase activity ----
         
    MMP15 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MMP15:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp15):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body  mortality/aging 
     normal 

    MMP15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp15tm1Kohl for MMP15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP15

    miRNA
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    hsa-mir-29b-3p (MIRT005383), hsa-mir-29c-3p (MIRT005384)

    Block miRNA regulation of human, mouse, rat MMP15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP15 (see all 19):
    hsa-miR-148b hsa-miR-1260b hsa-let-7a-2* hsa-miR-624* hsa-miR-144 hsa-miR-9 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidMMP15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP15
    Predesigned siRNA for gene silencing in human, mouse, rat MMP15

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MMP15 (NM_002428)
    Sino Biological Human cDNA Clone for MMP15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP15

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP15_HUMAN, P51511: Membrane; Single-pass type I membrane protein; Extracellular side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0031012extracellular matrix IEA--

    MMP15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP15 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MMP15
        Inhibition of Matrix Metalloproteinases

    1 GeneGo (Thomson Reuters) Pathway for MMP15
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP15
        Matrix Metalloproteinases


    3 Reactome Pathways for MMP15
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases



    MMP15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MMP15: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MMP15 (P515111, 2, 3 ENSP000002192714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PROCP040701, 3, ENSP000002340714EBI-1383043,EBI-1383018 I2D: score=1 STRING: ENSP00000234071
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    --Q9R0642MINT-7897801
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS7559440
    GO:0006508proteolysis ----
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    MMP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MMP15 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    1 Novoseek inferred chemical compound relationship for MMP15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 0 1 12773401 (1)



    MMP15 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP15 gene: 
    NM_002428.2  

    Unigene Cluster for MMP15:

    Matrix metallopeptidase 15 (membrane-inserted)
    Hs.80343  [show with all ESTs]
    Unigene Representative Sequence: NM_002428
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219271(uc002ena.3) ENST00000570065
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MMP15 (see all 19):
    hsa-miR-148b hsa-miR-1260b hsa-let-7a-2* hsa-miR-624* hsa-miR-144 hsa-miR-9 hsa-miR-149 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidMMP15 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat MMP15
      QuantiFast Probe-based Assays in human, mouse, rat MMP15

    Additional mRNA sequence: 

    BC006412.1 BC036495.1 BC055428.1 BT006715.1 D85510.1 D86331.1 Z48482.1 

    6 DOTS entries:

    DT.445739  DT.120678318  DT.100721538  DT.99991301  DT.86854977  DT.95265493 

    Selected AceView cDNA sequences (see all 150):

    AW206202 CR625537 AW161057 BM759721 D85510 BU185089 CR596713 BU160555 
    BM783580 AI658872 BU145572 AW183978 AI335961 CF139691 BC006412 NM_002428 
    AW235381 AI286199 BQ691783 BM766566 BM759722 Z48482 BM756734 BM759845 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGAGCG
    MMP15 Expression
    About this image


    MMP15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
    MMP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80343

    UniProtKB/Swiss-Prot: MMP15_HUMAN, P51511
    Tissue specificity: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine.
    Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including MMP15: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MMP15
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    QuantiFast Probe-based Assays in human, mouse, rat MMP15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP15 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp151 , 5 matrix metallopeptidase 151, 5 85.16(n)1
    88.72(a)1
      8 (47.12 cM)5
    173881  NM_008609.31  NP_032635.11 
     953522685 
    chicken
    (Gallus gallus)
    Aves MMP151 matrix metallopeptidase 15 (membrane-inserted) 75.76(n)
    76.24(a)
      415629  XM_413995.4  XP_413995.3 
    lizard
    (Anolis carolinensis)
    Reptilia MMP156
    matrix metallopeptidase 15 (membrane-inserted)
    66(a)
    1 ↔ 1
    GL344621.1(17828-27617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97112 Xenopus laevis transcribed sequence with weak similarity more 77.17(n)    BJ069397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003324261 matrix metalloproteinase-15-like 67.16(n)
    67.16(a)
      100332426  XM_002662908.3  XP_002662954.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp23 oogenesis metalloendopeptidase 51(a)     --


    ENSEMBL Gene Tree for MMP15 (if available)
    TreeFam Gene Tree for MMP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP15 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    12 SIMAP similar genes for MMP15 using alignment to 2 protein entries:     MMP15_HUMAN (see all proteins):
    MMP2    MMP16    MMP14    MMP24    MMP25    MMP8
    MMP17    MMP3    MMP10    MMP11    MMP20    MMP26

    MMP15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP15 (see all 530)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37599531,2
    C,F,H--58057345(+) AAATGA/CGGAAA 1 -- us2k1 tfbs328Minor allele frequency- C:0.08NA NS EA WA 2910
    rs1467473921,2
    C--58057575(+) TGAAAC/TGGTAT 1 -- us2k10--------
    rs1836203041,2
    --58057596(+) TGGATA/TAGGTT 1 -- us2k10--------
    rs1403495301,2
    --58057624(+) AGGGCG/TGCAGT 1 -- us2k10--------
    rs20605731,2
    C,F,O,A,H--58057627(-) TGAACC/TGCAGC 1 -- us2k138Minor allele frequency- T:0.40NA EA NS WA CSA 4699
    rs414153461,2
    C,F--58057743(+) CTCCCA/GAAGTA 1 -- us2k15Minor allele frequency- G:0.01NS 188
    rs1895054951,2
    --58057822(+) GCAGGA/GTTGGA 1 -- us2k10--------
    rs414154451,2
    C,F--58057939(+) GCCCCT/CTAAAC 1 -- us2k16Minor allele frequency- C:0.02NS NA 294
    rs413420461,2
    C--58057950(+) CCCAAC/TTTTTT 1 -- us2k15Minor allele frequency- T:0.01NS 174
    rs354846041,2
    C--58058362(+) CATTTC/TCCAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MMP15 (58059282 - 58080805 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MMP15:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2875n71CNV Loss21882294
    nsv906741CNV Loss21882294
    esv29262CNV Loss19812545
    nsv906740CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP15
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602261    OMIM disorders: --

    Selected diseases for MMP15 (see all 33):    
    About MalaCards
    chronic cholangitis    adenoid cystic carcinoma    encephalomyelitis    arthritis
    psoriatic arthritis    adenoiditis    papillary thyroid carcinoma    esophageal cancer
    cholangitis    transitional cell carcinoma    pulmonary function    chondrosarcoma
    esophageal squamous cell carcinoma    pancreatic cancer    hepatocellular carcinoma    esophagitis
    prostate cancer    breast and colorectal cancer    hypoxia    prostatitis


    MMP15 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MMP15 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 39.9 6 16033774 (2), 9708803 (1), 15279711 (1)
    metastasis 33.8 1 9736043 (1)
    glioblastoma 32.2 6 10027400 (4), 9708803 (2)
    carcinoma 25.1 5 9751409 (2), 9927064 (1), 10383907 (1)
    cervical carcinoma 24.1 1 11925127 (1)
    cancer 19.9 7 15739263 (2), 19915148 (2), 9685743 (1), 16093241 (1)
    tumors 19.2 14 10027400 (4), 10383907 (1), 11293899 (1), 9751409 (1) (see all 8)
    pancreatic cancer 12.5 2 10585576 (2)
    hepatocellular carcinoma 10.1 2 15870919 (1), 9736043 (1)
    necrosis 0 2 10531073 (1), 15581686 (1)

    Genetic Association Database (GAD): MMP15
    Human Genome Epidemiology (HuGE) Navigator: MMP15 (9 documents)

    Export disorders for MMP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP15 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with MMP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. (PubMed id 9119382)1, 2, 3 Sato H.... Seiki M. (Genomics 1997)
    2. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. (PubMed id 9070935)1, 3, 9 Mattei M.G....Apte S.S. (Genomics 1997)
    3. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    4. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad- spectrum proteolytic capacities comparable to many matrix metalloproteinases. (PubMed id 9461298)1, 2 d'Ortho M.P.... Murphy G. (Eur. J. Biochem. 1997)
    10. cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. (PubMed id 7649159)1, 2 Will H. and Hinzmann B. (Eur. J. Biochem. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4324 HGNC: 7161 AceView: MMP15 Ensembl:ENSG00000102996 euGenes: HUgn4324
    ECgene: MMP15 H-InvDB: MMP15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP15 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp15/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP15 gene:
    Search GeneIP for patents involving MMP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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