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MMP14 Gene

protein-coding GIFtS: 69

GC14P022375

matrix metallopeptidase 14 (membrane-inserted)
(Previous name: matrix metalloproteinase 14 (membrane-inserted) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.80 ^³
MMP-14 ^³
MMP-X1 ^², ³
MT1-MMP ^¹, ², ³
MT1MMP ^³
MTMMP1 ^², ³

Descriptions
MT-MMP 1 ^³
Membrane-type matrix metalloproteinase 1 ^², ³
Membrane-type-1 matrix metalloproteinase ^², ³
matrix metallopeptidase 14 (membrane-inserted) ^²
matrix metalloproteinase 14 ^²
matrix metalloproteinase 14 (membrane-inserted) ^¹, ²
membrane type 1 metalloprotease ^²

External Ids
HGNC: 7160¹
Entrez Gene: 4323²
UniProtKB: P50281³
Ensembl: ENSG00000157227⁷

Search outside databases for aliases for MMP14 gene

Previous GC identifers: GC14P020678 GC14P017093 GC14P021295

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MMP14:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of

extracellular matrix in normal physiological processes, such as embryonic development,

reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and

metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved

by extracellular proteinases. However, the protein encoded by this gene is a member of the

membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential

transmembrane domain suggesting that these proteins are expressed at the cell surface rather than

secreted. This protein activates MMP2 protein, and this activity may be involved in tumor

invasion. [provided by RefSeq]

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells

by activating progelatinase A on the tumor cell surface

Gene Wiki entry for MMP14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MMP14 gene

Entrez Gene cytogenetic band: 14q11-q12 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11-q12

MMP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P022375: (about GC identifiers)

Start:	22,375,633 bp from pter
End:	22,386,643 bp from pter
Size:	11,011 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281 (See protein sequence)

Recommended Name: Matrix metalloproteinase-14 precursor

Size: 582 amino acids; 65884 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Cofactor: Calcium (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Melanosome.

Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

PDB structures from and Proteopedia :

1BQQ (3D)

1BUV (3D)

3C7X (3D)

Secondary accessions: A8K5L0 Q6GSF3 Q92678

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004986.1

ENSEMBL proteins:

ENSP00000308208

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MMP14 Protein
	Sigma-Aldrich CompoZr ZFN for MMP14
	R&D Systems Recombinant & Natural Proteins for MMP14 (MMP-14)
	Enzo Life Sciences proteins for MMP14
	Recombinant Proteins from Abcam (MMP14)
	Human Recombinant Proteins from Abnova (MMP14)

OriGene Purified Recombinant Human Protein: MMP14

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005887	integral to plasma membrane	TAS	8015608
GO:0016020	membrane	IEA	--
GO:0042470	melanosome	IEA	--

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Antibodies for MMP14:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MMP14
	Sigma-Aldrich Antibodies for MMP14
	R&D Systems Antibodies for MMP14 (MMP-14)
	Antibodies from Abcam (MMP14), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MMP14)
	Novus Biologicals Antibodies for MMP14

Assays for MMP14:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for MMP14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50281

ProtoNet protein and cluster: P50281

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP14)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004995

Applied Biosystems Silencer® siRNAs for MMP14

Sigma-Aldrich siRNA and siRNA Panels for MMP14

Sigma-Aldrich shRNA Panels and shRNA for MMP14

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MMP14
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004995
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004995
untagged cDNA clone in CMV expression vector: NM_004995

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004995

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells

by activating progelatinase A on the tumor cell surface

Catalytic activity: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide

at 37-Asn- -Leu-38. Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of

collagenase 3, and 341-Asn- -Phe-342, 441-Asp- -Leu-442 and 354-Gln- -Thr-355 in the aggrecan

interglobular domain

Enzyme Number (IUBMB): EC 3.4.24.80

Genatlas biochemistry entry for MMP14:

matrix metalloproteinase 14,regulator in matrix remodeling in the MMP

cluster,membrane-type,involved in pathophysiology of malignant gliomas by glial invasion and

angiogenesis,required for the activation of MMP2 in the stronal cancer cells

15/22 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Mmp14) (see all 22 ):

	behavior/neurological	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle	no phenotypic analysis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	8015608
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	14718544
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	TAS	8015608

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for MMP14 (Your Favorite Gene powered by Ingenuity)

Bladder Cancer Signaling
Leukocyte Extravasation Signaling
HIF1&alpha

GeneDecks MMP14 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MMP14

5/70 Interacting proteins for MMP14 (ENSP00000308208³ P50281^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADI1	Q9BV57¹	STRING (score=.779) EBI-992788, EBI-992807
BCAR1	P56945²	STRING (score=.745) MINT-6174781 MINT-6174763 MINT-6174753
C1QBP	Q07021²	STRING (score=.98) MINT-14175 MINT-14176
ACTB	P60709²	STRING (score=.833) MINT-6174744
TIMP2 TIMP2 (xeno)	P16368¹^,²	EBI-992788, EBI-1027047 MINT-24800

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0001525	angiogenesis	IEA	--
GO:0001541	ovarian follicle development	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001935	endothelial cell proliferation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MMP14

Browse Small Molecules at Sigma-Aldrich

Compounds for MMP14 available from Tocris Bioscience

Compound	Action	CAS number
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

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10/45 Novoseek chemical compound relationships for MMP14 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	77.62	24	14962105 (2), 14647466 (2), 19276357 (1), 11688960 (1) (see all 17)
prinomastat	77.56	9	12594807 (2), 16940151 (1), 10415735 (1), 12456388 (1)
hydroxamate	56.35	10	9548812 (2), 9422789 (1), 16940151 (1), 11773076 (1) (see all 6)
con a	49.44	36	15534869 (5), 9371497 (4), 10601293 (4), 9514100 (3) (see all 12)
flavanol	35.65	1	12480918 (1)
1,10-phenanthroline	35.39	2	10551322 (1), 15095267 (1)
phorbol-12-myristate	30.24	3	11448964 (1), 11779859 (1)
grgdsp	26.96	3	9639398 (2)
sp 600125	23.77	5	16672691 (1), 19243022 (1), 12909329 (1), 18455449 (1)
tgf beta1	20.22	3	14644155 (1), 16820603 (1), 17187779 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP14)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004995

Sigma-Aldrich siRNA and siRNA Panels for MMP14

Sigma-Aldrich shRNA Panels and shRNA for MMP14

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004995

REFSEQ mRNAs for MMP14 gene:

NM_004995.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004995

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004995
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004995
                                 untagged cDNA clone in CMV expression vector: NM_004995

Additional cDNA sequence:

AK291325.1 AK312657.1 BC039581.1 BC064803.1 D26512.1 U41078.1 X83535.1 X90925.1

Z48481.1

6 DOTS entries:

DT.40213418 DT.100026651 DT.92051199 DT.120791834 DT.120791835 DT.97842905

24/178 AceView cDNA sequences (see all 178 ):

U41078 CA306664 CF126480 BE221730 BM684465 BU633583 BU633451 AI250922

AW662701 BX957084 BQ380078 X90925 CA397632 AI355953 Z48481 AI659098

AI078824 BC064803 AW591099 AW339032 AI004701 AI369080 BM541329 AW082531

highest scoring ESTs for MMP14:

X83535 Z48481 AI004701 AI052526 AI073653 AI078824 AI081315 AI093895 AI168705 AI333889

Unigene Cluster for MMP14:

Matrix metallopeptidase 14 (membrane-inserted)

Hs.2399 [show with all ESTs]

Unigene Representative Sequence: NM_004995

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000311852

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MMP14 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MMP14

¹ / ² / ³

11 probe-sets matching MMP14 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73002_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.31	AI052526	0.80	1.00	0.91	1
34747_at²^{, 3}	U95-A	1	1.00	1.00	-0.31	0.59	X83535	1.00	1.00	1.00	1
160020_at²^{, 3}	U133-A	1	1.00	1.00	0.46	1.12	Z48481	1.00	1.00	1.00	1
217279_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X83535	1.00	1.00	1.00	1
202828_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004995	0.60	1.00	0.82	1
202827_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU149305	0.60	1.00	0.82	1
160020_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Z48481	1.00	1.00	1.00	1
217279_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202828_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202827_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
160020_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MMP14 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGACCCCCAG

SOURCE GeneReport for Unigene cluster: Hs.2399
Expression variation in blood from EXPOLDB for MMP14
UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281
Tissue specificity: In stromal cells of colon, breast, and head and neck

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MMP14 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MMP14¹	--	matrix metallopeptidase 14 (membrane-inserted)	91.62(n) 96.9(a)	403823 XM_843664.1 XP_848757.1
chimpanzee (Pan troglodytes)	MMP14¹	--	matrix metallopeptidase 14 (membrane-inserted)	99.89(n) 99.66(a)	742887 XM_001157686.1 XP_001157686.1
cow (Bos taurus)	MMP14¹	--	matrix metallopeptidase 14 (membrane-inserted)	92.14(n) 96.04(a)	281915 NM_174390.2 NP_776815.1
rat (Rattus norvegicus)	Mmp14¹	--	matrix metallopeptidase 14 (membrane-inserted)	89.81(n) 96.74(a)	81707 NM_031056.1 NP_112318.1
mouse (Mus musculus)	Mmp14^{1, 5}	14 (12.50 cM)⁵	matrix metallopeptidase 14 (membrane-inserted)^{1, 5}	89.52(n)¹ 96.22(a)¹	17387¹ NM_008608.2¹ NP_032634.2¹ AF022424⁵ AF022425⁵ (see all 50)

About this table Species with no ortholog for MMP14

ENSEMBL Gene Tree for MMP14

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MMP14 gene

MMP16² MMP24² MMP15²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in MMP14 are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1042703^1,2	A,C,F,H	22375888(+)	`GACCCT/CCCCGT`	1	S/P	mis¹		13	MN EU EA WA NA NS	1308
	rs1003349^1,2	A,C,F,H	22375503(+)	`TTCCAG/TTTCTT`	1	--	ng5¹		18	EU EA WA NA NS	1808
	rs743257^1,2	A,C,F,H	22385171(+)	`GGCTGC/TTCCCA`	1	--	ut3¹		14	MN EU EA WA NA NS	1398
	rs762054^1,2	C,F,H	22386881(+)	`CACACG/ATCATA`	1	--	ng3¹		9	EA NA NS EU WA	722
	rs1042704^1,2	C,F,H	22382434(+)	`TGCCCG/AATGAT`	1	N/D	mis¹		19	MN NA NS EU EA WA	1992
	rs3751489^1,2	C,F,H	22383820(+)	`CTTCCG/ATGGAA`	1	H/R	mis¹		12	EA NA EU WA	2288
	rs10132595^1,2	C,F,H	22375341(+)	`GAGGAA/GTCAAG`	1	--	ng5¹		14	NA NS EU EA WA	1218
	rs17884694^1,2	C,F	22387036(+)	`GCTCTC/GCCACC`	1	--	ng3¹		7	NS	644
	rs17884816^1,2	C,F	22385878(+)	`TCAGGT/GAGGGT`	1	--	ut3¹		7	NS	652
--	rs11624302^1,2	C,F	22386287(+)	`GTCCCG/AGCCTG`	1	--	ut3¹		1	NS	164

About this table

HapMap Linkage Disequilibrium images for MMP14 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600754

10/92 Novoseek disease relationships for MMP14 gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosarcoma	73.36	47	10548512 (2), 9716492 (2), 15147870 (2), 18627313 (2) (see all 36)
metastasis	70.81	168	16419154 (5), 11182063 (5), 15563089 (5), 11235994 (3) (see all 81)
tumors	66.92	551	17156449 (6), 9221811 (5), 15581944 (5), 10208467 (5) (see all 99)
breast carcinoma	62.05	66	11335709 (3), 9062387 (2), 14597417 (2), 10551322 (2) (see all 39)
cancer	59.87	166	11848101 (4), 11172680 (3), 17938169 (3), 15563089 (3) (see all 93)
carcinoma	51.22	78	15095267 (5), 18976802 (4), 9751409 (4), 9927064 (3) (see all 40)
glioma	49.17	56	15743799 (7), 15279711 (5), 18021371 (4), 10895974 (3) (see all 19)
melanoma	48.16	66	14962105 (6), 18425363 (4), 10409657 (4), 15059909 (3) (see all 29)
carcinoma squamous cell	46.73	30	15756447 (3), 10820340 (2), 11235994 (2), 18080692 (2) (see all 20)
glioblastoma	46.58	37	11235952 (4), 10027400 (4), 10895974 (2), 9922462 (2) (see all 17)

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Human Genome Epidemiology Navigator: MMP14 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/868 PubMed articles for MMP14 gene (see all 868 ):

A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PubMed id 8015608)^{2, 3, 4} Sato H....Seiki M. (1994)
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PubMed id 8706726)^{1, 3, 4} Lohi J.L.... Keski-Oja J. (1996)
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. (PubMed id 9724659)^{1, 3, 4} Fernandez-Catalan C.... Maskos K. (1998)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. (PubMed id 8804434)^{3, 4} Sato H.... Seiki M. (1996)
cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. (PubMed id 7649159)^{3, 4} Will H. and Hinzmann B. (1995)
Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain. (PubMed id 7721107)^{3, 4} Takino T.... Seiki M. (1995)
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. (PubMed id 7708715)^{3, 4} Okada A.... Basset P. (1995)
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP). (PubMed id 16627478)^{1, 3} Remacle A.G....Strongin A.Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4323	HGNC: 7160	AceView: MMP14	Ensembl:ENSG00000157227	euGenes: HUgn4323
ECgene: MMP14	H-InvDB: MMP14

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MMP14	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp14/

Licensable Technologies for MMP14
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MMP14:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MMP14-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MMP14		Antibodies for MMP14
	Explore super-pooled esiRNAs		Proteins for MMP14
	Lentivirus-delivered shRNAs for MMP14		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MMP14)
	Antibodies (MMP14)
	Chimera RNAi (MMP14)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MMP14)
	Antibodies (MMP14)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for MMP14

	Assays/Drugs/Proteins for MMP14
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MMP14

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MMP14 Gene at Home site.
Version 2.41.1
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MMP14 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for MMP14

Summaries
for MMP14

Genomic Location
for MMP14

Proteins
for MMP14

Protein Domains/
Families
for MMP14

Gene Function
for MMP14

Pathways & Interactions
for MMP14

Drugs & Compounds
for MMP14

Transcripts
for MMP14

Expression
for MMP14

Orthologs
for MMP14

Paralogs
for MMP14

SNPs/Variants
for MMP14

Disorders & Mutations
for MMP14

Medical News
for MMP14

Publications
for MMP14

Search for MMP14

Genome Databases showing MMP14

Other Databases showing MMP14

Specialized Databases showing MMP14

Licensable Technologies
for MMP14

Services
for MMP14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MMP14 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor MMP14

Summariesfor MMP14

Genomic Locationfor MMP14

Proteinsfor MMP14

Protein Domains/Familiesfor MMP14

Gene Functionfor MMP14

Pathways & Interactionsfor MMP14

Drugs & Compoundsfor MMP14

Transcriptsfor MMP14

Expression for MMP14

Orthologsfor MMP14

Paralogsfor MMP14

SNPs/Variantsfor MMP14

Disorders & Mutationsfor MMP14

Medical Newsfor MMP14

Publicationsfor MMP14

Search for MMP14

Genome Databases showing MMP14

Other Databases showing MMP14

Specialized Databases showing MMP14

Licensable Technologiesfor MMP14

Servicesfor MMP14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MMP14

Summaries
for MMP14

Genomic Location
for MMP14

Proteins
for MMP14

Protein Domains/
Families
for MMP14

Gene Function
for MMP14

Pathways & Interactions
for MMP14

Drugs & Compounds
for MMP14

Transcripts
for MMP14

Expression
for MMP14

Orthologs
for MMP14

Paralogs
for MMP14

SNPs/Variants
for MMP14

Disorders & Mutations
for MMP14

Medical News
for MMP14

Publications
for MMP14

Licensable Technologies
for MMP14

Services
for MMP14