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Aliases for MMP14 Gene

Aliases for MMP14 Gene

  • Matrix Metallopeptidase 14 (Membrane-Inserted) 2 3
  • Membrane-Type-1 Matrix Metalloproteinase 3 4
  • Membrane Type 1 Metalloprotease 2 3
  • EC 3.4.24.80 4 63
  • MT-MMP 1 3 4
  • MT1-MMP 3 4
  • WNCHRS 3 6
  • MMP-14 3 4
  • MMP-X1 3 4
  • MT1MMP 3 4
  • MTMMP1 3 4
  • Matrix Metalloproteinase 14 (Membrane-Inserted) 2
  • Membrane-Type Matrix Metalloproteinase 1 4
  • Matrix Metalloproteinase-14 3
  • EC 3.4.24 63
  • MT-MMP 3

External Ids for MMP14 Gene

Previous GeneCards Identifiers for MMP14 Gene

  • GC14P020678
  • GC14P017093
  • GC14P021295
  • GC14P022375
  • GC14P023305
  • GC14P003422

Summaries for MMP14 Gene

Entrez Gene Summary for MMP14 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP14 Gene

MMP14 (Matrix Metallopeptidase 14 (Membrane-Inserted)) is a Protein Coding gene. Diseases associated with MMP14 include winchester syndrome and multicentric osteolysis, nodulosis, and arthropathy. Among its related pathways are Degradation of the extracellular matrix and HIF-2-alpha transcription factor network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP14 Gene

  • Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Tocris Summary for MMP14 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP14 Gene

Genomics for MMP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP14 Gene

Start:
22,836,533 bp from pter
End:
22,849,027 bp from pter
Size:
12,495 bases
Orientation:
Plus strand

Genomic View for MMP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP14 Gene

Proteins for MMP14 Gene

  • Protein details for MMP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50281-MMP14_HUMAN
    Recommended name:
    Matrix metalloproteinase-14
    Protein Accession:
    P50281
    Secondary Accessions:
    • A8K5L0
    • Q6GSF3
    • Q92678

    Protein attributes for MMP14 Gene

    Size:
    582 amino acids
    Molecular mass:
    65894 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts (via C-terminal cytoplasmic tail) with BST2.

    Three dimensional structures from OCA and Proteopedia for MMP14 Gene

neXtProt entry for MMP14 Gene

Proteomics data for MMP14 Gene at MOPED

Post-translational modifications for MMP14 Gene

Other Protein References for MMP14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP14 (MMP-14/MT1-MMP)
  • Cell Signaling Technology (CST) Antibodies for MMP14 (MMP14)

Assay Products

  • Enzo Life Sciences assays for MMP14

Domains for MMP14 Gene

Gene Families for MMP14 Gene

Suggested Antigen Peptide Sequences for MMP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50281

UniProtKB/Swiss-Prot:

MMP14_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP14: view

Function for MMP14 Gene

Molecular function for MMP14 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 14,regulator in matrix remodeling in the MMP cluster,membrane-type,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,required for the activation of MMP2 in the stronal cancer cells
UniProtKB/Swiss-Prot CatalyticActivity:
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn- -Leu-38. Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of collagenase 3, and 341-Asn- -Phe-342, 441-Asp- -Leu-442 and 354-Gln- -Thr-355 in the aggrecan interglobular domain
UniProtKB/Swiss-Prot Function:
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by NANOS1.

Enzyme Numbers (IUBMB) for MMP14 Gene

Gene Ontology (GO) - Molecular Function for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14718544
genes like me logo Genes that share ontologies with MMP14: view
genes like me logo Genes that share phenotypes with MMP14: view

Animal Models for MMP14 Gene

MGI Knock Outs for MMP14:

Animal Model Products

miRNA for MMP14 Gene

miRTarBase miRNAs that target MMP14

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP14

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MMP14 Gene

Localization for MMP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP14 Gene

Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP14 Gene COMPARTMENTS Subcellular localization image for MMP14 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 colocalizes_with cytoplasm IDA 22065321
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8015608
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with MMP14: view

Pathways for MMP14 Gene

genes like me logo Genes that share pathways with MMP14: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification --
GO:0001525 angiogenesis IEA --
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia IEA --
GO:0001935 endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with MMP14: view

Drugs for MMP14 Gene

(1) Drugbank Compounds for MMP14 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Marimastat
  • BB-2516
154039-60-8 119031 Target inhibitor approved, investigational

(5) Tocris Compounds for MMP14 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(2) ApexBio Compounds for MMP14 Gene

Compound Action Cas Number
Marimastat MMPs inhibitor,board spectrum [154039-60-8]
NSC 405020 MT1-MMP inhibitor [7497-7-6]

(2) HMDB Compounds for MMP14 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Marimastat
154039-60-8

(75) Novoseek inferred chemical compound relationships for MMP14 Gene

Compound -log(P) Hits PubMed IDs
batimastat 80.9 12
prinomastat 78.8 6
matrigel 76.8 19
ilomastat 66.3 2
marimastat 64.1 1
genes like me logo Genes that share compounds with MMP14: view

Compound Products

Transcripts for MMP14 Gene

mRNA/cDNA for MMP14 Gene

Unigene Clusters for MMP14 Gene

Matrix metallopeptidase 14 (membrane-inserted):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP14 Gene

No ASD Table

Relevant External Links for MMP14 Gene

GeneLoc Exon Structure for
MMP14
ECgene alternative splicing isoforms for
MMP14

Expression for MMP14 Gene

mRNA expression in normal human tissues for MMP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MMP14 Gene

This gene is overexpressed in Amniocyte (42.1), Bone (8.3), and Liver (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP14 Gene

SOURCE GeneReport for Unigene cluster for MMP14 Gene Hs.2399

mRNA Expression by UniProt/SwissProt for MMP14 Gene

P50281-MMP14_HUMAN
Tissue specificity: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
genes like me logo Genes that share expressions with MMP14: view

Expression partners for MMP14 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MMP14 Gene

Orthologs for MMP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP14 35
  • 92.03 (n)
  • 95.87 (a)
MMP14 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP14 35
  • 89.9 (n)
  • 95.18 (a)
MMP-14 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp14 35
  • 89.86 (n)
  • 96.56 (a)
Mmp14 16
Mmp14 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP14 35
  • 99.89 (n)
  • 99.66 (a)
MMP14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp14 35
  • 89.81 (n)
  • 96.74 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP14 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP14 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP14 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp14 35
  • 71.75 (n)
  • 78.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23718 35
zebrafish
(Danio rerio)
Actinopterygii mmp14b 35
mmp14b 35
  • 68.46 (n)
  • 72.05 (a)
mmp14a 36
  • 68 (a)
OneToMany
mmp14b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 38 (a)
Mmp2 37
  • 30 (a)
Mmp1 35
  • 53.08 (n)
  • 42.27 (a)
Mmp2 36
  • 26 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006904 35
  • 49.57 (n)
  • 41.28 (a)
worm
(Caenorhabditis elegans)
Secernentea H19M22.3a 37
  • 32 (a)
H36L18.1 35
  • 45.74 (n)
  • 34.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for MMP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP14 Gene

ENSEMBL:
Gene Tree for MMP14 (if available)
TreeFam:
Gene Tree for MMP14 (if available)

Paralogs for MMP14 Gene

(18) SIMAP similar genes for MMP14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MMP14: view

Variants for MMP14 Gene

Sequence variations from dbSNP and Humsavar for MMP14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs536679421 -- 22,846,181(+) GGCTG(A/G)CCTCC utr-variant-3-prime
rs536769749 -- 22,845,661(+) TCCTC(C/T)CTTTG intron-variant
rs536474411 -- 22,844,092(+) CCTGG(G/T)AGGCT intron-variant
rs536472819 -- 22,845,840(+) TGAGG(A/G)GACTG missense, reference
rs536336726 -- 22,846,267(+) GAGGG(C/T)GGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MMP14 Gene

Variant ID Type Subtype PubMed ID
nsv901490 CNV Loss 21882294

Relevant External Links for MMP14 Gene

HapMap Linkage Disequilibrium report
MMP14
Human Gene Mutation Database (HGMD)
MMP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP14 Gene

Disorders for MMP14 Gene

(1) OMIM Diseases for MMP14 Gene (600754)

UniProtKB/Swiss-Prot

MMP14_HUMAN
  • Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269 PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for MMP14 Gene

(92) Novoseek inferred disease relationships for MMP14 Gene

Disease -log(P) Hits PubMed IDs
fibrosarcoma 73.7 43
metastasis 70.8 137
tumors 67.2 269
breast carcinoma 62.3 52
cancer 60.7 135

Relevant External Links for MMP14

Genetic Association Database (GAD)
MMP14
Human Genome Epidemiology (HuGE) Navigator
MMP14
genes like me logo Genes that share disorders with MMP14: view

No data available for Genatlas for MMP14 Gene

Publications for MMP14 Gene

  1. Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PMID: 8706726) Lohi J.L. … Keski-Oja J. (Eur. J. Biochem. 1996) 3 4 23
  2. A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PMID: 8015608) Sato H. … Seiki M. (Nature 1994) 2 3 4
  3. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PMID: 18223680) Bonnomet A. … Nawrocki-Raby B. (Oncogene 2008) 3 4 23
  4. Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer. (PMID: 18174174) Cao J. … Zucker S. (J. Biol. Chem. 2008) 3 23
  5. Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation. (PMID: 17938169) Golubkov V.S. … Strongin A.Y. (J. Biol. Chem. 2007) 3 23

Products for MMP14 Gene

Sources for MMP14 Gene

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