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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP14 Gene

protein-coding GIFtS: 70
GCID: GC14P023305

matrix metallopeptidase 14 (membrane-inserted)

(Previous name: matrix metalloproteinase 14 (membrane-inserted) )

Explore 139 diseases affiliated with
MMP14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 14 (Membrane-Inserted)¹ ²		MTMMP1² ³
MT1-MMP¹ ² ³		MT-MMP 1² ³
Matrix Metalloproteinase 14 (Membrane-Inserted)¹ ²		EC 3.4.24.80³ ⁸
Membrane-Type Matrix Metalloproteinase 1² ³		1²
Membrane-Type-1 Matrix Metalloproteinase² ³		MT-MMP²
MMP-14² ³		Matrix Metalloproteinase-14²
MMP-X1² ³		Membrane Type 1 Metalloprotease²
MT1MMP² ³		EC 3.4.24⁸

External Ids:	HGNC: 7160¹	Entrez Gene: 4323²	Ensembl: ENSG00000157227⁷	OMIM: 600754⁵	UniProtKB: P50281³

Export aliases for MMP14 gene to outside databases

Previous GC identifers: GC14P020678 GC14P017093 GC14P021295 GC14P022375 GC14P003422

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP14:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP

(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these

proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this

activity may be involved in tumor invasion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating

progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts

as a positive regulator of cell growth and migration via activation of MMP15

summary for MMP14:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP14 gene promoter:
AP-2alpha isoform 3 AP-1 ATF-2 AP-4 AP-2alpha isoform 2 AREB6 AP-2alpha isoform 4 c-Jun AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP14 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11-q12 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11-q12

MMP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP14 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P023305: view genomic region (about GC identifiers)

Start:	23,305,766 bp from pter	End:	23,318,236 bp from pter
Size:	12,471 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281 (See protein sequence)

Recommended Name: Matrix metalloproteinase-14 precursor

Size: 582 amino acids; 65894 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Cofactor: Calcium (By similarity)

Subunit: Interacts (via C-terminal cytoplasmic tail) with BST2

Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Cytoplasm. Note=Identified

by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the

cytoplasm

4 PDB 3D structures from and Proteopedia for MMP14:

1BQQ (3D)

1BUV (3D)

3C7X (3D)

3MA2 (3D)

Secondary accessions: A8K5L0 Q6GSF3 Q92678

Explore the universe of human proteins at neXtProt for MMP14: NX_P50281

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50281

4/16 DME Specific Peptides for MMP14 (P50281) (see all 16)

LRDWMGC

FVFFKGD

PRCGVPD

DDRRGIQ

MMP14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004986.1

ENSEMBL proteins:

ENSP00000308208 ENSP00000450323 ENSP00000446989

Reactome Protein details: P50281
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MMP14 Protein
	R&D Systems Recombinant & Natural Proteins for MMP14 (MMP-14/MT1-MMP)
	Enzo Life Sciences proteins for MMP14
	OriGene Purified Protein: MMP14 OriGene Protein Over-expression Lysate: MMP14 OriGene Custom Protein Services for MMP14
	GenScript Custom Purified and Recombinant Proteins Services for MMP14
	Novus Biologicals MMP14 Protein Novus Biologicals MMP14 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MMP14

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	colocalizes with cytoplasm	IDA	--
GO:0005796	Golgi lumen	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8015608
GO:0031012	extracellular matrix	IEA	--

MMP14 for ontologies About GeneDecksing

MMP14 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP14
	R&D Systems Antibodies for MMP14 (MMP-14/MT1-MMP)
	OriGene Antibodies: MMP14 OriGene Custom Antibody Services for MMP14
	GenScript Custom Superior Antibodies Services for MMP14
	Novus Biologicals MMP14 Antibodies
	Abcam antibodies for MMP14
	Uscn Antibodies for MMP14
	ThermoFisher Antibodies for MMP14

Assay Products for MMP14:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript MMP14-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP14
	Uscn ELISAs and CLIAs for MMP14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP14 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P50281

ProtoNet protein and cluster: P50281

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating

progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts

as a positive regulator of cell growth and migration via activation of MMP15

Catalytic activity: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn- -Leu-38.

Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of collagenase 3, and 341-Asn- -Phe-342, 441-Asp-

-Leu-442 and 354-Gln- -Thr-355 in the aggrecan interglobular domain

Induction: Up-regulated by NANOS1

Genatlas biochemistry entry for MMP14:

matrix metalloproteinase 14,regulator in matrix remodeling in the MMP cluster,membrane-type,involved in pathophysiology

of malignant gliomas by glial invasion and angiogenesis,required for the activation of MMP2 in the stronal cancer

cells

Enzyme Numbers (IUBMB): EC 3.4.24.80¹ ² EC 3.4.24²

miRNA Products:		OriGene 3'-UTR Clone: MMP14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP14
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP14 (see all 48):
		hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-1914* hsa-miR-374a hsa-miR-759 hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: MMP14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP14 (see all 7) OriGene shRNA RFP: MMP14 OriGene siRNA: MMP14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP14

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP14 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP14 (NM_004995)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP14

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP14
		Search LifeMap BioReagents cell lines for MMP14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP14

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--

MMP14 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for MMP14: Mmp14^tm1Ktry Mmp14^tm1Noda Mmp14^tm1Hbh Mmp14^tm1Ski
     15/25 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Mmp14) (see all 25):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
homeostasis/metabolism	immune system	integument	limbs/digits/tail	mortality/aging

MMP14 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Cell adhesion_ECM remodeling

	Cell adhesion_ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion ECM remodeling	1.00

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

MT-MMPs are sorted to the plasma membrane

MT-MMPs are sorted to the plasma membrane

1.00

AGE/RAGE pathway

AGE/RAGE pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MMP14

	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP14

	Inhibition of Matrix Metalloproteinases
	Colorectal Cancer Metastasis

1 GeneGo (Thomson Reuters) Pathway for MMP14

Cell adhesion ECM remodeling

5 BioSystems Pathways for MMP14

	AGE/RAGE pathway
	Senescence and Autophagy
	Matrix Metalloproteinases
	Signaling events mediated by focal adhesion kinase
	HIF-2-alpha transcription factor network

5/6 Reactome Pathways for MMP14 (see all 6)

	Extracellular matrix organization
	Extracellular matrix organization
	MT-MMPs are sorted to the plasma membrane
	Degradation of the extracellular matrix
	Degradation of collagen

1 Kegg Pathway (Kegg details for MMP14):

GnRH signaling pathway

MMP14 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/46 Interacting proteins for MMP14 (P50281^{1, 2, 3} ENSP00000308208⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C1QBP	Q07021²^,³, ENSP00000225698⁴	MINT-14175 MINT-14176 I2D: score=3 STRING: ENSP00000225698
ADI1	Q9BV57¹^,³, ENSP00000333666⁴	EBI-992788,EBI-992807 I2D: score=2 STRING: ENSP00000333666
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-6174744 I2D: score=1 STRING: ENSP00000349960
FURIN	P09958²^,³, ENSP00000268171⁴	MINT-7898002 I2D: score=1 STRING: ENSP00000268171
GOLGB1	Q14789²^,³, ENSP00000341848⁴	MINT-7897500 I2D: score=1 STRING: ENSP00000341848

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0001525	angiogenesis	IEA	--
GO:0001541	ovarian follicle development	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001935	endothelial cell proliferation	IEA	--

MMP14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP14 for compounds About GeneDecksing

EMD Millipore small molecules for MMP14:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for MMP14 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP14 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MMP14 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951

10/75 Novoseek chemical compound relationships for MMP14 gene (see all 75) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
batimastat	80.9	14	16473349 (2), 17640303 (2), 14962105 (1), 15466200 (1) (see all 10)
prinomastat	78.8	12	12594807 (2), 16940151 (1), 20215503 (1), 10415735 (1) (see all 5)
matrigel	76.8	24	14962105 (2), 14647466 (2), 19276357 (1), 11688960 (1) (see all 17)
ilomastat	66.3	2	11335709 (1), 18984345 (1)
marimastat	64.1	2	11790786 (1)
hydroxamate	54.7	10	9548812 (2), 9422789 (1), 16940151 (1), 11773076 (1) (see all 6)
con a	47.7	36	15534869 (5), 9371497 (4), 10601293 (4), 9514100 (3) (see all 12)
cytochalasin d	47.2	16	10996658 (3), 16672691 (2), 17460268 (2), 12198653 (1) (see all 9)
vegf	43.2	54	12918061 (4), 9742524 (3), 14729679 (3), 11809713 (3) (see all 24)
egcg	41.5	24	12480918 (5), 15172120 (2), 11853893 (2), 16051878 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about MMP14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP14 gene:

NM_004995.2

Unigene Cluster for MMP14:

Matrix metallopeptidase 14 (membrane-inserted)

Hs.2399 [show with all ESTs]

Unigene Representative Sequence: NM_004995

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311852(uc001whc.3) ENST00000547074 ENST00000548162 ENST00000547279

ENST00000548761 ENST00000547596

miRNA Products:		OriGene 3'-UTR Clone: MMP14 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP14
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate MMP14 (see all 48):
		hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-1914* hsa-miR-374a hsa-miR-759 hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: MMP14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP14 (see all 7) OriGene shRNA RFP: MMP14 OriGene siRNA: MMP14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP14

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP14 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP14 (NM_004995)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP14

Additional cDNA sequence:

AK291325.1 AK312657.1 BC039581.1 BC064803.1 D26512.1 HE978355.1 U41078.1 X83535.1

X90925.1 Z48481.1

6 DOTS entries:

DT.40213418 DT.100026651 DT.92051199 DT.120791834 DT.120791835 DT.97842905

24/178 AceView cDNA sequences (see all 178):

AW082531 BC064803 BQ380078 AI078824 BP364337 AI004701 BQ888922 BP359226

BU633583 CF126480 BE221730 BX957084 AW591099 CA397632 X90925 BF876480

BU179229 AI355953 AW079724 BM541329 AI250922 AW662701 AW339032 AI369080

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACCCCCAG

About this image

MMP14 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Growth Plate

Terminal Chondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Caudal Endochondral Bones

Terminal Chondrocytes

Bone, Cartilage

Bone

Cervical Vertebrae

Terminal Chondrocytes

Bone, Cartilage

Bone

Endochondral Facial Bones

Terminal Chondrocytes

Bone, Cartilage

Bone

Lumbar Vertebrae

Terminal Chondrocytes

Bone, Cartilage

Bone

Rostral Endochondral Facial Bones

Terminal Chondrocytes

Bone, Cartilage

Bone

Sacral Vertebrae

Terminal Chondrocytes

Bone, Cartilage

Bone

Stylopod Growth Plate

Terminal Chondrocytes

Bone, Cartilage

Bone

Thoracic Rib

Terminal Chondrocytes

Bone, Cartilage

Bone

Thoracic Vertebrae

Terminal Chondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

See MMP14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP14

SOURCE GeneReport for Unigene cluster: Hs.2399

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281

Tissue specificity: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP14:

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Angiogenesis in human mouse rat

Cell Motility in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP14 gene from 7/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MMP14⁶	--	79(a)	1 ↔ 1	GL343491.1(581212-597255)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23718²	Xenopus laevis transcribed sequence with moderate similarity more	79.58(n)		CD254471.1
zebrafish (Danio rerio)	Actinopterygii	mmp14b²	matrix metalloproteinase 14 (membrane-inserted) beta	77.49(n)		373880 AY324197.1
fruit fly (Drosophila melanogaster)	Insecta	Mmp1^{1 , 3}	tracheal system development (sensu Insecta) metalloendopeptidase³ Matrix metalloproteinase 1¹	38(a) (best of 2)³ 52.1(n)¹ 40.94(a)¹		37949¹ NM_166683.1¹ NP_726473.2¹
worm (Caenorhabditis elegans)	Secernentea	H19M22.3a³	protease	32(a)		III(2708405-2714076) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT4G16640⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	27(a) 25(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 4(9367248-9368775)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	9(a) 26(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 2(30974996-30977090)

ENSEMBL Gene Tree for MMP14 (if available)
TreeFam Gene Tree for MMP14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP14 gene

MMP13² MMP20² MMP8² MMP9² MMP16² MMP2² MMP25² MMP24²

MMP15² MMP11² MMP3² MMP27² MMP17² MMP10² MMP1²

18/20 SIMAP similar genes for MMP14 using alignment to 4 protein entries: MMP14_HUMAN (see all proteins) (see all similar genes):

MMP16 MMP24 MMP15 mmp20 MMP7 MMP17

MMP8 MMP12 MMP25 MMP13 MMP3 MMP11

MMP10 MMP2 MMP20 MMP1 MMP26 MMP27

MMP14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111561410^1,2	C,F,	--	23303918(+)	`CGGGCG/ATGGTG`	7	--	us2k¹ ut3¹		1		NA	120
rs61608320^1,2	C,	--	23303981(+)	`AAACTC/TGGGAG`	7	--	ut3¹ us2k¹		1		WA	2
rs143683198^1,2		--	23304015(+)	`TCACAA/CCATTG`	7	--	ut3¹ us2k¹		0	--	--	--	--
rs1957371^1,2	C,F,A,	--	23304051(+)	`GACTCT/CGTCTC`	7	--	ut3¹ us2k¹		4		NA WA CSA	8
rs56341631^1,2	C	--	23304057(+)	`GTCTC-/AAAAAA`	7	--	ut3¹ us2k¹		0	--	--	--	--
rs3751488^1,2	C,F,H,	--	23304094(+)	`CCATAA/GGACTA`	7	--	ut3¹ us2k¹ tfbs³		27		NS EA NA WA	2986
rs184386255^1,2		--	23304125(+)	`TGTTCC/TGTGAA`	7	--	us2k¹ ut3¹		0	--	--	--	--
rs17886536^1,2	C,F,	--	23304254(+)	`TTCTAG/CCCAAG`	7	--	us2k¹ ds500¹		6		NS NA WA	416
rs17211964^1,2	C,F,H,	--	23304272(+)	`TTTTGG/CCAAGC`	7	--	ds500¹ us2k¹ tfbs³		25		NA NS EA	2482
rs186945145^1,2		--	23304289(+)	`TGTCAA/GTCTTC`	7	--	us2k¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MMP14 (23305766 - 23318236 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP14: --
Human Gene Mutation Database (HGMD): MMP14

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP14 for disorders           About GeneDecksing

OMIM gene information: 600754    OMIM disorders: --

20/139 diseases for MMP14 (see all 139):    About MalaCards

arthritis encephalomyelitis familial adenomatous polyposis focal segmental glomerulosclerosis

aortic aneurysm dermatofibrosarcoma protuberans lichen planus malignant fibrous histiocytoma

oral lichen planus abdominal aortic aneurysm cervical squamous cell carcinoma type 2 diabetes mellitus

thymic epithelial tumor pediatric ependymoma severe combined immunodeficiency macular degeneration

2 diseases from the University of Copenhagen DISEASES database for MMP14:

Arthritis Carcinoma

10/92 Novoseek disease relationships for MMP14 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosarcoma	73.7	54	10548512 (2), 9716492 (2), 15147870 (2), 18627313 (2) (see all 39)
metastasis	70.8	185	16419154 (5), 11182063 (5), 15563089 (5), 19402080 (4) (see all 87)
tumors	67.2	612	17156449 (6), 9221811 (5), 15581944 (5), 10208467 (5) (see all 99)
breast carcinoma	62.3	68	11335709 (3), 9062387 (2), 14597417 (2), 10551322 (2) (see all 40)
cancer	60.7	191	11848101 (4), 19915148 (3), 17938169 (3), 20117087 (3) (see all 99)
carcinoma	51	78	15095267 (5), 18976802 (4), 9751409 (4), 9927064 (3) (see all 40)
glioma	50.8	61	15743799 (7), 15279711 (5), 18021371 (4), 19617536 (4) (see all 20)
pathological processes	49.1	21	15561768 (1), 18955496 (1), 19136391 (1), 19109023 (1) (see all 9)
melanoma	47	68	14962105 (6), 18425363 (4), 10409657 (4), 15059909 (3) (see all 30)
ovarian carcinoma	45.7	24	11089877 (3), 19509114 (2), 17158885 (2), 10197640 (1) (see all 14)

Human Genome Epidemiology (HuGE) Navigator: MMP14 (18 documents)

Export disorders for MMP14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP14 gene, integrated from 9 sources (see all 1046):
(articles sorted by number of sources associating them with MMP14)

Utopia: connect your pdf to the dynamic
world of online information

A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PubMed id 8015608)^{1, 2, 3} Sato H....Seiki M. (1994)
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PubMed id 8706726)^{1, 2, 9} Lohi J.L.... Keski-Oja J. (1996)
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. (PubMed id 9724659)^{1, 2, 9} Fernandez-Catalan C.... Maskos K. (1998)
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PubMed id 18223680)^{1, 2, 9} Bonnomet A....Nawrocki-Raby B. (2008)
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. (PubMed id 20837484)^{1, 2} Golubkov V.S.... Strongin A.Y. (2010)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. (PubMed id 8804434)^{1, 2} Sato H.... Seiki M. (1996)
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. (PubMed id 7708715)^{1, 2} Okada A.... Basset P. (1995)
cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. (PubMed id 7649159)^{1, 2} Will H. and Hinzmann B. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4323	HGNC: 7160	AceView: MMP14	Ensembl:ENSG00000157227	euGenes: HUgn4323
ECgene: MMP14	Kegg: 4323	H-InvDB: MMP14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP14	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp14/

Intellectual Property for MMP14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP14 gene:
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GeneCards and IP:
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matrix metallopeptidase 14 (membrane-inserted)

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MMP14 Gene

matrix metallopeptidase 14 (membrane-inserted)

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