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Aliases for MMP14 Gene

Aliases for MMP14 Gene

  • Matrix Metallopeptidase 14 2 3 5
  • Matrix Metallopeptidase 14 (Membrane-Inserted) 2 3
  • Membrane-Type-1 Matrix Metalloproteinase 3 4
  • Membrane Type 1 Metalloprotease 2 3
  • EC 3.4.24.80 4 61
  • MT-MMP 1 3 4
  • MT1-MMP 3 4
  • MMP-14 3 4
  • MMP-X1 3 4
  • MT1MMP 3 4
  • MTMMP1 3 4
  • Matrix Metalloproteinase 14 (Membrane-Inserted) 2
  • Membrane-Type Matrix Metalloproteinase 1 4
  • Matrix Metalloproteinase-14 3
  • EC 3.4.24 61
  • MT-MMP 3
  • WNCHRS 3

External Ids for MMP14 Gene

Previous GeneCards Identifiers for MMP14 Gene

  • GC14P020678
  • GC14P017093
  • GC14P021295
  • GC14P022375
  • GC14P023305
  • GC14P003422
  • GC14P022837

Summaries for MMP14 Gene

Entrez Gene Summary for MMP14 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP14 Gene

MMP14 (Matrix Metallopeptidase 14) is a Protein Coding gene. Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and metalloendopeptidase activity. An important paralog of this gene is MMP15.

UniProtKB/Swiss-Prot for MMP14 Gene

  • Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Tocris Summary for MMP14 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP14 Gene

Genomics for MMP14 Gene

Regulatory Elements for MMP14 Gene

Enhancers for MMP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MMP14 on UCSC Golden Path with GeneCards custom track

Promoters for MMP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP14 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP14 Gene

Chromosome:
14
Start:
22,836,533 bp from pter
End:
22,849,027 bp from pter
Size:
12,495 bases
Orientation:
Plus strand

Genomic View for MMP14 Gene

Genes around MMP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP14 Gene

Proteins for MMP14 Gene

  • Protein details for MMP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50281-MMP14_HUMAN
    Recommended name:
    Matrix metalloproteinase-14
    Protein Accession:
    P50281
    Secondary Accessions:
    • A8K5L0
    • Q6GSF3
    • Q92678

    Protein attributes for MMP14 Gene

    Size:
    582 amino acids
    Molecular mass:
    65894 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling (PubMed:21572390).

    Three dimensional structures from OCA and Proteopedia for MMP14 Gene

neXtProt entry for MMP14 Gene

Post-translational modifications for MMP14 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Tyrosine phosphorylated by PKDCC/VLK.
  • Glycosylation at Thr 77, Thr 291, Thr 299, Thr 300, Ser 301, and Ser 304
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Enzo Life Sciences assays for MMP14
  • Cloud-Clone Corp Assay Kits for MMP14
  • Abcam assays for MMP14

Domains & Families for MMP14 Gene

Gene Families for MMP14 Gene

Suggested Antigen Peptide Sequences for MMP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50281

UniProtKB/Swiss-Prot:

MMP14_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP14: view

Function for MMP14 Gene

Molecular function for MMP14 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 14,regulator in matrix remodeling in the MMP cluster,membrane-type,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,required for the activation of MMP2 in the stronal cancer cells
UniProtKB/Swiss-Prot CatalyticActivity:
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn- -Leu-38. Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of collagenase 3, and 341-Asn- -Phe-342, 441-Asp- -Leu-442 and 354-Gln- -Thr-355 in the aggrecan interglobular domain.
UniProtKB/Swiss-Prot Function:
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by NANOS1.

Enzyme Numbers (IUBMB) for MMP14 Gene

Gene Ontology (GO) - Molecular Function for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,ISS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005178 integrin binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14718544
genes like me logo Genes that share ontologies with MMP14: view
genes like me logo Genes that share phenotypes with MMP14: view

Human Phenotype Ontology for MMP14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MMP14 Gene

MGI Knock Outs for MMP14:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MMP14 Gene

Localization for MMP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP14 Gene

Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP14 Gene COMPARTMENTS Subcellular localization image for MMP14 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 colocalizes_with cytoplasm IEA,IDA 22065321
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8015608
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with MMP14: view

Pathways & Interactions for MMP14 Gene

genes like me logo Genes that share pathways with MMP14: view

SIGNOR curated interactions for MMP14 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MMP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia IEA --
GO:0001935 endothelial cell proliferation IEA --
GO:0001958 endochondral ossification IEA --
genes like me logo Genes that share ontologies with MMP14: view

Drugs & Compounds for MMP14 Gene

(44) Drugs for MMP14 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
Prinomastat Investigational Pharma inhibitor, Vaccine Vaccines 3
calcium Nutra 0
NSC 405020 Pharma MT1-MMP inhibitor 0

(37) Additional Compounds for MMP14 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP14 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9

(3) ApexBio Compounds for MMP14 Gene

Compound Action Cas Number
Marimastat MMPs inhibitor,board spectrum 154039-60-8
NSC 405020 MT1-MMP inhibitor 7497-07-6
Ro 32-3555 MMP inhibitor 190648-49-8
genes like me logo Genes that share compounds with MMP14: view

Drug Products

Transcripts for MMP14 Gene

Unigene Clusters for MMP14 Gene

Matrix metallopeptidase 14 (membrane-inserted):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP14 Gene

No ASD Table

Relevant External Links for MMP14 Gene

GeneLoc Exon Structure for
MMP14
ECgene alternative splicing isoforms for
MMP14

Expression for MMP14 Gene

mRNA expression in normal human tissues for MMP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP14 Gene

This gene is overexpressed in Amniocyte (42.1), Bone (8.3), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP14 Gene



Protein tissue co-expression partners for MMP14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP14 Gene:

MMP14

SOURCE GeneReport for Unigene cluster for MMP14 Gene:

Hs.2399

mRNA Expression by UniProt/SwissProt for MMP14 Gene:

P50281-MMP14_HUMAN
Tissue specificity: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
genes like me logo Genes that share expression patterns with MMP14: view

Primer Products

No data available for mRNA differential expression in normal tissues for MMP14 Gene

Orthologs for MMP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP14 35
  • 100 (a)
OneToOne
MMP14 34
  • 99.89 (n)
  • 99.66 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MMP14 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP14 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp14 16
Mmp14 34
  • 89.86 (n)
  • 96.56 (a)
Mmp14 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP14 34
  • 89.9 (n)
  • 95.18 (a)
MMP-14 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP14 34
  • 92.03 (n)
  • 95.87 (a)
MMP14 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp14 34
  • 89.81 (n)
  • 96.74 (a)
lizard
(Anolis carolinensis)
Reptilia MMP14 35
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23718 34
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp14 34
  • 71.75 (n)
  • 78.99 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp14a 35
  • 68 (a)
OneToMany
mmp14b 35
  • 63 (a)
OneToMany
mmp14b 34
  • 68.46 (n)
  • 72.05 (a)
mmp14b 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006904 34
  • 49.57 (n)
  • 41.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 34
  • 53.08 (n)
  • 42.27 (a)
Mmp2 36
  • 30 (a)
Mmp1 36
  • 38 (a)
Mmp2 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H19M22.3a 36
  • 32 (a)
H36L18.1 34
  • 45.74 (n)
  • 34.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
ManyToMany
Species where no ortholog for MMP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP14 Gene

ENSEMBL:
Gene Tree for MMP14 (if available)
TreeFam:
Gene Tree for MMP14 (if available)

Paralogs for MMP14 Gene

(18) SIMAP similar genes for MMP14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MMP14: view

Variants for MMP14 Gene

Sequence variations from dbSNP and Humsavar for MMP14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17882219 - 22,836,827(+) CTCCC(A/G)CCCCA reference, missense
rs17884647 - 22,836,834(+) CCCAA(A/G)ACCCT reference, missense
rs1042703 - 22,836,839(+) GACCC(C/T)CCCGT reference, missense
rs17884841 - 22,843,265(+) ATGAC(A/G)TCTTC reference, missense
rs1042704 - 22,843,385(+) TGCCC(A/G)ATGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP14 Gene

Variant ID Type Subtype PubMed ID
esv3633763 CNV gain 21293372
nsv1070211 CNV deletion 25765185
nsv1143607 CNV deletion 24896259
nsv563998 CNV gain 21841781
nsv952816 CNV deletion 24416366

Variation tolerance for MMP14 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP14 Gene

Human Gene Mutation Database (HGMD)
MMP14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP14 Gene

Disorders for MMP14 Gene

MalaCards: The human disease database

(19) MalaCards diseases for MMP14 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
winchester syndrome
  • winchester disease
multicentric osteolysis, nodulosis, and arthropathy
  • multicentric osteolysis nodulosis and arthropathy
klatskin's tumor
  • hilar cholangiocarcinoma
actinic keratosis
  • seborrheic keratosis
light chain deposition disease
  • light-chain deposition disease
- elite association - COSMIC cancer census association via MalaCards
Search MMP14 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP14_HUMAN
  • Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269 PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MMP14

Genetic Association Database (GAD)
MMP14
Human Genome Epidemiology (HuGE) Navigator
MMP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP14
genes like me logo Genes that share disorders with MMP14: view

No data available for Genatlas for MMP14 Gene

Publications for MMP14 Gene

  1. Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PMID: 8706726) Lohi J.L. … Keski-Oja J. (Eur. J. Biochem. 1996) 3 4 22 65
  2. A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PMID: 8015608) Sato H. … Seiki M. (Nature 1994) 2 3 4 65
  3. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (PMID: 22922033) Evans B.R. … Martignetti J.A. (Am. J. Hum. Genet. 2012) 3 4 65
  4. BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. (PMID: 22065321) Gu G. … Liu P. (J. Cell. Biochem. 2012) 3 4 65
  5. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. (PMID: 21572390) Jin G. … Zhou Z. (EMBO J. 2011) 3 4 65

Products for MMP14 Gene

Sources for MMP14 Gene

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