Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MMP14 Gene

protein-coding   GIFtS: 74
GCID: GC14P023305

Matrix Metallopeptidase 14 (Membrane-Inserted)

(Previous name: matrix metalloproteinase 14 (membrane-inserted))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Matrix Metallopeptidase 14 (Membrane-Inserted)1 2     MT-MMP 12 3
Membrane Type 1 Metalloprotease1 2     EC 3.4.24.803 8
Membrane-Type-1 Matrix Metalloproteinase2 3     WNCHRS2 5
MMP-142 3     Matrix Metalloproteinase 14 (Membrane-Inserted)1
MMP-X12 3     MT-MMP2
MT1-MMP2 3     Matrix Metalloproteinase-142
MT1MMP2 3     Membrane-Type Matrix Metalloproteinase 13
MTMMP12 3     EC 3.4.248

External Ids:    HGNC: 71601   Entrez Gene: 43232   Ensembl: ENSG000001572277   OMIM: 6007545   UniProtKB: P502813   

Export aliases for MMP14 gene to outside databases

Previous GC identifers: GC14P020678 GC14P017093 GC14P021295 GC14P022375 GC14P003422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MMP14 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the
membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain
suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates
MMP2 protein, and this activity may be involved in tumor invasion. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMP14 Gene:
MMP14 (matrix metallopeptidase 14 (membrane-inserted)) is a protein-coding gene. Diseases associated with MMP14 include klatskin's tumor, and winchester syndrome. GO annotations related to this gene include metalloendopeptidase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281
Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating
progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of
the fibrovascular tissues in association with pro-MMP2

summary for MMP14 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP14 gene promoter:
         AP-2alpha isoform 3   AP-1   ATF-2   AP-4   AP-2alpha isoform 2   AREB6   AP-2alpha isoform 4   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP14 promoter sequence
   Search Chromatin IP Primers for MMP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11-q12

MMP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP14 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023305:  view genomic region     (about GC identifiers)

Start:
23,305,766 bp from pter      End:
23,318,236 bp from pter
Size:
12,471 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281 (See protein sequence)
Recommended Name: Matrix metalloproteinase-14 precursor  
Size: 582 amino acids; 65894 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Cofactor: Calcium (By similarity)
Subunit: Interacts (via C-terminal cytoplasmic tail) with BST2
4 PDB 3D structures from and Proteopedia for MMP14:
1BQQ (3D)        1BUV (3D)        3C7X (3D)        3MA2 (3D)    
Secondary accessions: A8K5L0 Q6GSF3 Q92678

Explore the universe of human proteins at neXtProt for MMP14: NX_P50281

Explore proteomics data for MMP14 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Thr77, Thr291, Thr299, Thr300, Ser301, Ser304
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP14 (P50281) (see all 16)
     LRDWMGC  FVFFKGD  PRCGVPD  DDRRGIQ 


    See MMP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004986.1  
    ENSEMBL proteins: 
     ENSP00000308208   ENSP00000450323   ENSP00000446989  
    Reactome Protein details: P50281

    MMP14 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MMP14 Protein
    R&D Systems Recombinant & Natural Proteins for MMP14 (MMP-14/MT1-MMP)
    Enzo Life Sciences proteins for MMP14
    OriGene Purified Protein for MMP14
    OriGene Protein Over-expression Lysate for MMP14
    OriGene MassSpec for MMP14
    OriGene Custom Protein Services for MMP14
    GenScript Custom Purified and Recombinant Proteins Services for MMP14
    Novus Biologicals MMP14 Protein
    Novus Biologicals MMP14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP14

    MMP14 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP14
    R&D Systems Antibodies for MMP14 (MMP-14/MT1-MMP)
    OriGene Antibodies for MMP14
    OriGene Custom Antibody Services for MMP14
    Novus Biologicals MMP14 Antibodies
    Abcam antibodies for MMP14
    Cloud-Clone Corp. Antibodies for MMP14
    ThermoFisher Antibody for MMP14
    LSBio Antibodies in human, mouse, rat for MMP14

    MMP14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP14
    Browse R&D Systems for biochemical assays
    GenScript MMP14-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP14
    Cloud-Clone Corp. ELISAs for MMP14
    Cloud-Clone Corp. CLIAs for MMP14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP14
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 12):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P50281

    ProtoNet protein and cluster: P50281

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP14_HUMAN, P50281
    Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating
    progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
    Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of
    the fibrovascular tissues in association with pro-MMP2
    Catalytic activity: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-
    -Leu-38. Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of collagenase 3, and 341-Asn-
    -Phe-342, 441-Asp- -Leu-442 and 354-Gln- -Thr-355 in the aggrecan interglobular domain
    Induction: Up-regulated by NANOS1

         Genatlas biochemistry entry for MMP14:
    matrix metalloproteinase 14,regulator in matrix remodeling in the MMP cluster,membrane-type,involved in
    pathophysiology of malignant gliomas by glial invasion and angiogenesis,required for the activation of MMP2 in
    the stronal cancer cells

         Enzyme Numbers (IUBMB): EC 3.4.24.801 2 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI14718544
         
    MMP14 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Mmp14) (see all 26):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    MMP14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MMP14: Mmp14tm1Ktry Mmp14tm1Noda Mmp14tm1Hbh Mmp14tm1Ski

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP14

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP14:
    hsa-mir-145-5p (MIRT021533), hsa-mir-335-5p (MIRT016970)

    Block miRNA regulation of human, mouse, rat MMP14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP14 (see all 48):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-1914* hsa-miR-374a hsa-miR-759 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMMP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP14
    Predesigned siRNA for gene silencing in human, mouse, rat MMP14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP14

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP14 (see all 6)
    OriGene ORF clones in mouse, rat for MMP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP14 (NM_004995)
    Sino Biological Human cDNA Clone for MMP14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP14
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MMP14_HUMAN, P50281: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Cytoplasm.
    Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2
    and localizes to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    plasma membrane4
    extracellular3
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737colocalizes with cytoplasm IDA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8015608
    GO:0031012extracellular matrix IEA--

    MMP14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MMP14 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    4Development Endothelin 1 EDNRA signaling
    GnRH signaling pathway0.38
    5TNF signaling pathway
    TNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP14
        Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis

    1 GeneGo (Thomson Reuters) Pathway for MMP14
        Cell adhesion ECM remodeling

    5 BioSystems Pathways for MMP14
        Senescence and Autophagy
    Matrix Metalloproteinases
    AGE/RAGE pathway
    HIF-2-alpha transcription factor network
    Signaling events mediated by focal adhesion kinase


    3 Reactome Pathways for MMP14
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases


    2 Kegg Pathways  (Kegg details for MMP14):
        TNF signaling pathway
    GnRH signaling pathway


    MMP14 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP14: 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenesis in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MMP14 (P502811, 2, 3 ENSP000003082084) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Gorasp2Q9R0641, 2EBI-992788,EBI-4422912 MINT-7898032 MINT-7897750 MINT-7897907 MINT-7897725 MINT-7897617 MINT-7897884 MINT-7897394 MINT-7898011 MINT-7897659 MINT-7898052 MINT-7897702 MINT-7897410 MINT-7897681 MINT-7897577
    C1QBPQ070212, 3, ENSP000002256984MINT-14175 MINT-14176 I2D: score=3 STRING: ENSP00000225698
    ADI1Q9BV571, 3, ENSP000003336664EBI-992788,EBI-992807 I2D: score=2 STRING: ENSP00000333666
    ACTBP607092, 3, ENSP000003499604MINT-6174744 I2D: score=1 STRING: ENSP00000349960
    FURINP099582, 3, ENSP000002681714MINT-7898002 I2D: score=1 STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001525angiogenesis IEA--
    GO:0001541ovarian follicle development IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001935endothelial cell proliferation IEA--

    MMP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MMP14 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP14    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MMP14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951

    Selected Novoseek inferred chemical compound relationships for MMP14 gene (see all 75)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    batimastat 80.9 14 16473349 (2), 17640303 (2), 14962105 (1), 15466200 (1) (see all 10)
    prinomastat 78.8 12 12594807 (2), 16940151 (1), 20215503 (1), 10415735 (1) (see all 5)
    matrigel 76.8 24 14962105 (2), 14647466 (2), 19276357 (1), 11688960 (1) (see all 17)
    ilomastat 66.3 2 11335709 (1), 18984345 (1)
    marimastat 64.1 2 11790786 (1)
    hydroxamate 54.7 10 9548812 (2), 9422789 (1), 16940151 (1), 11773076 (1) (see all 6)
    con a 47.7 36 15534869 (5), 9371497 (4), 10601293 (4), 9514100 (3) (see all 12)
    cytochalasin d 47.2 16 10996658 (3), 16672691 (2), 17460268 (2), 12198653 (1) (see all 9)
    vegf 43.2 54 12918061 (4), 9742524 (3), 14729679 (3), 11809713 (3) (see all 24)
    egcg 41.5 24 12480918 (5), 15172120 (2), 11853893 (2), 16051878 (1) (see all 8)



    MMP14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MMP14 gene: 
    NM_004995.3  

    Unigene Cluster for MMP14:

    Matrix metallopeptidase 14 (membrane-inserted)
    Hs.2399  [show with all ESTs]
    Unigene Representative Sequence: NM_004995
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311852(uc001whc.3) ENST00000547074 ENST00000548162 ENST00000547279
    ENST00000548761 ENST00000547596
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MMP14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP14 (see all 48):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-193a-3p hsa-miR-1914* hsa-miR-374a hsa-miR-759 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMMP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MMP14
    Predesigned siRNA for gene silencing in human, mouse, rat MMP14
    Clone
    Products:
         
    OriGene clones in human, mouse for MMP14 (see all 6)
    OriGene ORF clones in mouse, rat for MMP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP14 (NM_004995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MMP14
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP14
      QuantiTect SYBR Green Assays in human, mouse, rat MMP14
      QuantiFast Probe-based Assays in human, mouse, rat MMP14

    Additional mRNA sequence: 

    AK291325.1 AK312657.1 BC039581.1 BC064803.1 D26512.1 HE978355.1 U41078.1 X83535.1 
    X90925.1 Z48481.1 

    6 DOTS entries:

    DT.40213418  DT.100026651  DT.92051199  DT.120791834  DT.120791835  DT.97842905 

    Selected AceView cDNA sequences (see all 178):

    BU633583 AW192560 BF876480 BP359226 AI369080 CA306664 AI004701 BE221730 
    AI078824 BQ009340 AW591099 CF126480 AI250922 U41078 BM684465 BQ380078 
    BC064803 BP364337 BX957084 CA397632 AW082531 AW079724 AI355953 X90925 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MMP14 expression in normal human tissues (normalized intensities)      MMP14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCCCCAG
    MMP14 Expression
    About this image


    MMP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Terminal Chondrocytes Endochondral Facial Bones
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Terminal Chondrocytes Temporomandibular Joint
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Odontoblasts Dentin
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
    MMP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2399

    UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281
    Tissue specificity: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP14: 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenesis in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MMP14
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP14
    QuantiTect SYBR Green Assays in human, mouse, rat MMP14
    QuantiFast Probe-based Assays in human, mouse, rat MMP14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MMP14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp141 , 5 matrix metallopeptidase 14 (membrane-inserted)1, 5 89.86(n)1
    96.56(a)1
      14 (27.79 cM)5
    173871  NM_008608.31  NP_032634.31 
     544316045 
    lizard
    (Anolis carolinensis)
    Reptilia MMP146
    matrix metallopeptidase 14 (membrane-inserted)
    82(a)
    1 ↔ 1
    GL343491.1(578665-596982)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237182 Xenopus laevis transcribed sequence with moderate similarity more 79.58(n)    CD254471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp14b2 matrix metalloproteinase 14 (membrane-inserted) beta 77.49(n)   373880  AY324197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp11 , 3 tracheal system development (sensu
    Insecta) metalloendopeptidase3
    Matrix metalloproteinase 11
    38(a)
    (best of 2)3
    53.08(n)1
    42.27(a)1
      379491  NM_166683.11  NP_726473.21 
    worm
    (Caenorhabditis elegans)
    Secernentea H19M22.3a3
    H36L18.11
    protease3
    H36L18.11
    32(a)3
    45.74(n)1
    34.57(a)1
      III(2708405-2714076)3
    1868051  NM_077711.21  NP_510112.21 


    ENSEMBL Gene Tree for MMP14 (if available)
    TreeFam Gene Tree for MMP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MMP14 gene
    MMP202  MMP132  MMP82  MMP252  MMP162  MMP72  MMP242  MMP152  
    MMP32  MMP112  MMP272  MMP172  MMP102  MMP12  
    18 SIMAP similar genes for MMP14 using alignment to 4 protein entries:     MMP14_HUMAN (see all proteins):
    MMP16    MMP24    MMP15    mmp20    MMP7    MMP17
    MMP8    MMP12    MMP25    MMP13    MMP3    MMP11
    MMP10    MMP2    MMP20    MMP1    MMP26    MMP27

    MMP14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MMP14 (see all 380)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0705674
    Winchester syndrome (WNCHRS)4--see VAR_0705672 T R mis40--------
    rs359221701,2
    C--4307982(+) AAGTC-/C/TT  
            
    ACCCA
    1 -- int10--------
    rs178823511,2
    C,F--23304829(+) GCTGAT/CAGTCT 1 -- us2k12Minor allele frequency- C:0.02NS NA 282
    rs1843179271,2
    --23304867(+) CTTCTC/GTTGTG 1 -- us2k10--------
    rs178848251,2
    C,F--23304923(+) TCTCAC/TGGTCA 1 -- us2k18Minor allele frequency- T:0.02NS NA 760
    rs1892962471,2
    --23304924(+) CTCACA/GGTCAG 1 -- us2k10--------
    rs1151197451,2
    F--23305014(+) TCTTTA/GAGAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1484489341,2
    C--23305052(+) ACTAAA/TCCCCA 1 -- us2k10--------
    rs1808727261,2
    --23305239(+) AGATCC/TGGTAT 1 -- us2k10--------
    rs171230361,2
    C,F--23305303(+) AGAGGG/AAGGGA 1 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.09EA 120

    HapMap Linkage Disequilibrium report for MMP14 (23305766 - 23318236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901490CNV Loss21882294

    Human Gene Mutation Database (HGMD): MMP14
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MMP14
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600754   
    OMIM disorders: 277950  
    UniProtKB/Swiss-Prot: MMP14_HUMAN, P50281
  • Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and
    feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features
    include coarse face, corneal opacities, gum hypertrophy, and EKG changes. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for MMP14 (see all 120):    About MalaCards
    klatskin's tumor    winchester syndrome    torg winchester syndrome    pediatric ependymoma
    laryngeal carcinoma    cervical squamous cell carcinoma    fibrosarcoma    thymic epithelial tumor
    keratoconus    brain glioma    laryngitis    cerebral aneurysms
    refractive error    arteriovenous fistula    marfan syndrome    encephalomyelitis
    arthritis    embryonal rhabdomyosarcoma    dermatofibrosarcoma    dermatofibrosarcoma protuberans

    2 diseases from the University of Copenhagen DISEASES database for MMP14:
    Arthritis     Carcinoma

    MMP14 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MMP14 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 73.7 54 10548512 (2), 9716492 (2), 15147870 (2), 18627313 (2) (see all 39)
    metastasis 70.8 185 16419154 (5), 11182063 (5), 15563089 (5), 19402080 (4) (see all 87)
    tumors 67.2 612 17156449 (6), 9221811 (5), 15581944 (5), 10208467 (5) (see all 99)
    breast carcinoma 62.3 68 11335709 (3), 9062387 (2), 14597417 (2), 10551322 (2) (see all 40)
    cancer 60.7 191 11848101 (4), 19915148 (3), 17938169 (3), 20117087 (3) (see all 99)
    carcinoma 51 78 15095267 (5), 18976802 (4), 9751409 (4), 9927064 (3) (see all 40)
    glioma 50.8 61 15743799 (7), 15279711 (5), 18021371 (4), 19617536 (4) (see all 20)
    pathological processes 49.1 21 15561768 (1), 18955496 (1), 19136391 (1), 19109023 (1) (see all 9)
    melanoma 47 68 14962105 (6), 18425363 (4), 10409657 (4), 15059909 (3) (see all 30)
    ovarian carcinoma 45.7 24 11089877 (3), 19509114 (2), 17158885 (2), 10197640 (1) (see all 14)

    Genetic Association Database (GAD): MMP14
    Human Genome Epidemiology (HuGE) Navigator: MMP14 (18 documents)

    Export disorders for MMP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MMP14 gene, integrated from 10 sources (see all 1083):
    (articles sorted by number of sources associating them with MMP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PubMed id 8015608)1, 2, 3 Sato H....Seiki M. (Nature 1994)
    2. Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PubMed id 8706726)1, 2, 9 Lohi J.L.... Keski-Oja J. (Eur. J. Biochem. 1996)
    3. Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population. (PubMed id 20110530)1, 4, 9 Wipff J....Allanore Y. (J. Rheumatol. 2010)
    4. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. (PubMed id 9724659)1, 2, 9 Fernandez-Catalan C.... Maskos K. (EMBO J. 1998)
    5. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. (PubMed id 18784838)1, 4, 9 Hadchouel A....Delacourt C. (PLoS ONE 2008)
    6. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PubMed id 18223680)1, 2, 9 Bonnomet A.... Nawrocki-Raby B. (Oncogene 2008)
    7. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (PubMed id 22922033)1, 2 Evans B.R....Martignetti J.A. (Am. J. Hum. Genet. 2012)
    8. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4323 HGNC: 7160 AceView: MMP14 Ensembl:ENSG00000157227 euGenes: HUgn4323
    ECgene: MMP14 Kegg: 4323 H-InvDB: MMP14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MMP14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP14 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp14/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MMP14 gene:
    Search GeneIP for patents involving MMP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP14
     EMD Millipore Purified and/or Recombinant MMP14 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for MMP14 (MMP-14/MT1-MMP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for MMP14 (MMP-14/MT1-MMP)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MMP14   OriGene RNAi products in human, mouse, rat for MMP14  
     OriGene qPCR primer pairs and template standards for MMP14   OriGene Protein Over-expression Lysate for MMP14  
     OriGene MassSpec something-or-other for MMP14   OriGene clones in human, mouse for MMP14  
     OriGene qSTAR qPCR primer pairs in human, mouse for MMP14   OriGene Purified Protein for MMP14  
     OriGene ORF clones in mouse, rat for MMP14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MMP14   OriGene Custom Protein Services for MMP14  

     
     
     Block miRNA regulation of human, mouse, rat MMP14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MMP14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP14 Predesigned siRNA for gene silencing in human, mouse, rat MMP14
     QuantiFast Probe-based Assays in human, mouse, rat MMP14 QuantiTect SYBR Green Assays in human, mouse, rat MMP14
     PCR Arrays including human, mouse, rat MMP14 Search Chromatin IP Primers for MMP14
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP14  GeneGlobe Interaction Network for MMP14
     Regulatory tfbs in MMP14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MMP14 GenScript cDNA clones with any tag delivered in your preferred vector for MMP14
     GenScript MMP14-Activity-based typehere Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for MMP14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MMP14
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MMP14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for MMP14
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MMP14 antibodies
     MMP14 proteins
     MMP14 lysates
     Antibodies for MMP14
     See all of Abcam's Antibodies, Kits and Proteins for MMP14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MMP14
     Antibodies for MMP14
     ELISAs for MMP14
     CLIAs for MMP14



     Browse ESI BIO Cell Lines and PureStem Progenitors for MMP14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP14
     SwitchGear 3'UTR luciferase reporter plasmids for MMP14
     SwitchGear Promoter luciferase reporter plasmids for MMP14
     ThermoFisher Antibody for MMP14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP14
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP14
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP14
     LSBio Antibodies in human, mouse, rat for MMP14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for MMP14
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MMP14 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4