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MMP12 Gene

protein-coding GIFtS: 68

GC11M102238

matrix metallopeptidase 12 (macrophage elastase)
(Previous name: matrix metalloproteinase 12 (macrophage elastase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.65 ^³
HME ^¹, ², ³
ME ^³
MGC138506 ^²
MME ^²
MMP-12 ^³

Descriptions
Macrophage elastase ^², ³
Matrix metalloproteinase-12 ^³
macrophage metalloelastase ^²
matrix metallopeptidase 12 (macrophage elastase) ^²
matrix metalloproteinase 12 ^²
matrix metalloproteinase 12 (macrophage elastase) ^¹, ²

External Ids
HGNC: 7158¹
Entrez Gene: 4321²
UniProtKB: P39900³
Ensembl: ENSG00000110347⁷

Search outside databases for aliases for MMP12 gene

Previous GC identifers: GC11M104927 GC11M104090 GC11M102767 GC11M102271

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MMP12:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of

extracellular matrix in normal physiological processes, such as embryonic development,

reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and

metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved

by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at

both ends to yield the active enzyme, but this processing has not been fully described. The enzyme

degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in

mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes

which localize to chromosome 11q22.3. [provided by RefSeq]

UniProtKB/Swiss-Prot: MMP12_HUMAN, P39900

Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity.

Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic

or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably

alanine) occupying P3

Gene Wiki entry for MMP12 (Matrix_metallopeptidase_12)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MMP12 gene

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3

MMP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102238: (about GC identifiers)

Start:	102,238,674 bp from pter
End:	102,250,922 bp from pter
Size:	12,249 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MMP12_HUMAN, P39900 (See protein sequence)

Recommended Name: Macrophage metalloelastase precursor

Size: 470 amino acids; 54002 Da

Cofactor: Binds 4 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

PDB structures from and Proteopedia :

1JIZ (3D)

1JK3 (3D)

1OS2 (3D)

1OS9 (3D)

1RMZ (3D)

1ROS (3D)

1UTT (3D)

1UTZ (3D)

1Y93 (3D)

1YCM (3D)

1Z3J (3D)

2HU6 (3D)

2JXY (3D)

2K2G (3D)

2K9C (3D)

2OXU (3D)

2OXW (3D)

2OXZ (3D)

2POJ (3D)

2W0D (3D)

2Z2D (3D)

3BA0 (3D)

3F15 (3D)

3F16 (3D)

3F17 (3D)

3F18 (3D)

3F19 (3D)

3F1A (3D)

Secondary accessions: Q2M1L9

REFSEQ proteins: NP_002417.2

ENSEMBL proteins:

ENSP00000320664

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MMP12 Protein
	Sigma-Aldrich Proteins for MMP12
	R&D Systems Recombinant & Natural Proteins for MMP12 (MMP-12)
	Enzo Life Sciences proteins for MMP12
	Recombinant Proteins from Abcam (MMP12)
	Human Recombinant Proteins from Abnova (MMP12)

OriGene Purified Recombinant Human Protein: MMP12

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--

About this table

Antibodies for MMP12:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MMP12
	Sigma-Aldrich Antibodies for MMP12
	R&D Systems Antibodies for MMP12 (MMP-12)
	Antibodies from Abcam (MMP12), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MMP12)
	Novus Biologicals Antibodies for MMP12

Assays for MMP12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems Multiplex/Array Assay Kits & Reagents for MMP12 (MMP-12) (see all)
	Enzo Life Sciences assays for MMP12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P39900

ProtoNet protein and cluster: P39900

2 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

UniProtKB/Swiss-Prot: MMP12_HUMAN, P39900

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002426

Applied Biosystems Silencer® siRNAs for MMP12

Sigma-Aldrich siRNA and siRNA Panels for MMP12

Sigma-Aldrich shRNA Panels and shRNA for MMP12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002426
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002426
untagged cDNA clone in CMV expression vector: NM_002426

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002426

UniProtKB/Swiss-Prot: MMP12_HUMAN, P39900

Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity.

Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic

or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably

alanine) occupying P3

Catalytic activity: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also

produced at 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in the B chain of insulin

Induction: By exposure to lipopolysaccharide. Inhibited by dexamethasone

Enzyme Number (IUBMB): EC 3.4.24.65

Genatlas biochemistry entry for MMP12:

matrix metalloproteinase 12,regulator in matrix remodeling in the MMP cluster,expressed in alveolar

macrophage and placental cells,mRNA upregulated in rheumatoid arthritis

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp12):

homeostasis/metabolism	immune system	nervous system	reproductive system	respiratory system
skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	8226919
GO:0005509	calcium ion binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	TAS	8226919

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for MMP12 (Your Favorite Gene powered by Ingenuity)

Bladder Cancer Signaling
HIF1&alpha
Leukocyte Extravasation Signaling

GeneDecks MMP12 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MMP12

5/27 Interacting proteins for MMP12 (ENSP00000320664³) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIMP1	ENSP00000218388³	STRING (score=.925)
ELN	ENSP00000351807³	STRING (score=.918)
ITGB6	ENSP00000283249³	STRING (score=.904)
TGFB1	ENSP00000221930³	STRING (score=.902)
CSF2	ENSP00000296871³	STRING (score=.89)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	8226919
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MMP12

Browse Small Molecules at Sigma-Aldrich

Compounds for MMP12 available from Tocris Bioscience

Compound	Action	CAS number
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]
UK 370106	Highly selective MMP-3 and MMP-12 inhibitor	[230961-21-4]

About this table

10/12 Novoseek chemical compound relationships for MMP12 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxamate	53.79	5	11575929 (2), 12504900 (1), 16674108 (1)
zinc	30.45	9	15289103 (2), 12504900 (1), 11575929 (1), 16737445 (1)
matrigel	24.39	1	16917801 (1)
lipid	3.78	1	18823978 (1)
oxygen	2.77	1	15905571 (1)
fibrinogen	0.00	4	10930399 (3)
oligonucleotide	0.00	1	9550265 (1)
nitric oxide	0.00	3	10973958 (1), 12455029 (1)
calcium	0.00	13	16737445 (4), 11575929 (1)
vitamin-e	0.00	3	12190877 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002426

Sigma-Aldrich siRNA and siRNA Panels for MMP12

Sigma-Aldrich shRNA Panels and shRNA for MMP12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002426

REFSEQ mRNAs for MMP12 gene:

NM_002426.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002426

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002426
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002426
                                 untagged cDNA clone in CMV expression vector: NM_002426

Additional cDNA sequence:

AK313959.1 BC112301.1 BC143773.1 CR594246.1 CR603756.1 L23808.1

3 DOTS entries:

DT.310810 DT.91727117 DT.95263647

24/67 AceView cDNA sequences (see all 67 ):

CR603756 BQ012914 AL552270 BQ011440 AV716402 AI368844 CB241588 BQ011671

AW170498 AL552239 BE466604 CR594246 AI707582 BP352329 N41366 BE440047

AW197615 AL569775 NM_002426 BG218179 BG215020 BX115664 BG206655 N30838

highest scoring ESTs for MMP12:

L23808 AL543115 BE003054 BE440047 BF327435 BF327450 AI299124 AI635789 AL569775 AW361840

Unigene Cluster for MMP12:

Matrix metallopeptidase 12 (macrophage elastase)

Hs.1695 [show with all ESTs]

Unigene Representative Sequence: NM_002426

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000326227

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MMP12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MMP12

¹ / ² / ³

4 probe-sets matching MMP12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1481_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.94	L23808	1.00	1.00	1.00	1
1482_g_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.08	L23808	1.00	1.00	1.00	1
204580_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002426	0.60	1.00	0.82	1
204580_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCTGTAAGT

SOURCE GeneReport for Unigene cluster: Hs.1695
Expression variation in blood from EXPOLDB for MMP12
UniProtKB/Swiss-Prot: MMP12_HUMAN, P39900
Tissue specificity: Found in alveolar macrophages but not in peripheral blood monocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MMP12 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MMP12¹	--	matrix metallopeptidase 12 (macrophage elastase)	79.72(n) 70.9(a)	611789 XM_849501.1 XP_854594.1
chimpanzee (Pan troglodytes)	MMP12¹	--	matrix metallopeptidase 12 (macrophage elastase)	99.36(n) 99.15(a)	451512 XM_508724.2 XP_508724.2
cow (Bos taurus)	MMP12¹	--	matrix metallopeptidase 12 (macrophage elastase)	78.96(n) 68.91(a)	526981 XM_605366.3 XP_605366.3
rat (Rattus norvegicus)	Mmp12¹	--	matrix metallopeptidase 12	75.34(n) 64.43(a)	117033 NM_053963.1 NP_446415.1
mouse (Mus musculus)	Mmp12^{1, 5}	9 (1.00 cM)⁵	matrix metallopeptidase 12^{1, 5}	75.63(n)¹ 63.34(a)¹	17381¹ NM_008605.3¹ NP_032631.3¹ AK089295⁵ AK089309⁵ (see all 50)

About this table Species with no ortholog for MMP12

ENSEMBL Gene Tree for MMP12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MMP12 gene

MMP20² MMP13² MMP7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/129 NCBI SNPs in MMP12 are shown (see all 129 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 100)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1277718^1,2	A,C,F,H,O	102252761(+)	`agTCTG/CTTTCC`	1	--	ng3¹		7	EU EA WA NA	556
	rs626729^1,2	A,C,F,H	102238580(-)	`TGACTA/GTATCA`	1	--	ng5¹		4	EU EA WA	420
	rs652438^1,2	A,C,F,H	102241852(-)	`TAGCAA/GTTTAA`	1	N/S	mis¹		18	MN EU EA WA NA NS	2834
	rs2276109^1,2	C,F,H,O	102251001(-)	`CAACTA/GTGAGT`	1	--	ng3¹ tfbs³		12	NA EU EA WA NS	734
	rs686375^1,2	A,C,F,H	102238444(-)	`GGAGTG/ACTTAC`	1	--	ng5¹		10	EU EA WA NA NS	673
	rs17099720^1,2	C,F,H	102252266(+)	`TTATCA/GATCCT`	1	--	ng3¹		12	NA EU EA WA NS	750
	rs12808148^1,2	C,F,H	102238373(+)	`TTGACC/TGTGGA`	1	--	ng5¹		17	NA NS EA EU WA	1244
--	rs28360355^1,2	F	102252000(-)	`TTTTT-/TCTATA`	1	--	ng3¹ tfbs³		5	NS	188
	rs28360354^1,2	F	102252174(-)	`ACTTTG/TTGTCA`	1	--	ng3¹ tfbs³		5	NS	190
	rs28360353^1,2	F	102252529(-)	`GTAGAC/TACTTT`	1	--	ng3¹		5	NS	188

About this table

HapMap Linkage Disequilibrium images for MMP12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601046

10/47 Novoseek disease relationships for MMP12 gene (see all 47 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
solar elastosis	62.01	1	12190877 (1)
pulmonary disease chronic obstructive	58.15	13	18619044 (2), 15355665 (1), 15723202 (1), 19236151 (1) (see all 6)
pulmonary emphysema	57.79	1	9082500 (1)
atherosclerotic plaque	44.07	4	10825169 (1), 15073384 (1), 17194896 (1), 18823978 (1)
inflammation	42.50	21	16510458 (3), 18001475 (2), 14656045 (1), 19167457 (1) (see all 12)
aortic aneurysm abdominal	41.49	6	9835614 (1), 16122719 (1), 16082623 (1), 17182940 (1) (see all 5)
bronchoalveolar lavage fluid	39.69	2	9230755 (1)
dermatitis herpetiformis	35.44	3	10201535 (1), 11247893 (1)
atherosclerosis	34.18	24	18403602 (5), 10825169 (2), 15359603 (1), 15531779 (1) (see all 8)
metastasis	31.00	16	15709175 (2), 18396640 (2), 17357518 (2), 11923608 (2) (see all 9)

About this table

Human Gene Mutation Database: MMP12
Genetic Association Database: MMP12
Human Genome Epidemiology Navigator: MMP12 (28 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/265 PubMed articles for MMP12 gene (see all 265 ):

Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. (PubMed id 11575929)^{1, 3, 4} Nar H.... Jung B. (2001)
Substrate specificity determinants of human macrophage elastase (MMP- 12) based on the 1.1 A crystal structure. (PubMed id 11575928)^{1, 3, 4} Lang R....Maskos K. (2001)
Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. (PubMed id 9115292)^{1, 3, 4} Gronski T.J. Jr.... Shapiro S.D. (1997)
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. (PubMed id 8226919)^{1, 3, 4} Shapiro S.D.... Ley T.J. (1993)
Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (PubMed id 16082623)^{1, 3, 6} Eriksson P....Powell J.T. (2005)
The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. (PubMed id 11875051)^{1, 3, 6} Joos L....Sandford A.J. (2002)
Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. (PubMed id 16311244)^{1, 3, 6} Su L....Christiani D.C. (2006)
Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. (PubMed id 11546917)^{1, 3, 6} Zhang B....Ye S. (2001)
Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study. (PubMed id 15987457)^{3, 6} Shin A....Zheng W. (2005)
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)^{3, 6} Ogata T....Kuivaniemi H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4321	HGNC: 7158	AceView: MMP12	Ensembl:ENSG00000110347	euGenes: HUgn4321
ECgene: MMP12	H-InvDB: MMP12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MMP12	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp12/

Licensable Technologies for MMP12
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MMP12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MMP12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MMP12		Antibodies for MMP12
	Explore super-pooled esiRNAs		Proteins for MMP12
	Lentivirus-delivered shRNAs for MMP12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Antibodies for MMP12

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MMP12 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for MMP12

Summaries
for MMP12

Genomic Location
for MMP12

Proteins
for MMP12

Protein Domains/
Families
for MMP12

Gene Function
for MMP12

Pathways & Interactions
for MMP12

Drugs & Compounds
for MMP12

Transcripts
for MMP12

Expression
for MMP12

Orthologs
for MMP12

Paralogs
for MMP12

SNPs/Variants
for MMP12

Disorders & Mutations
for MMP12

Medical News
for MMP12

Publications
for MMP12

Search for MMP12

Genome Databases showing MMP12

Other Databases showing MMP12

Specialized Databases showing MMP12

Licensable Technologies
for MMP12

Services
for MMP12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MMP12 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor MMP12

Summariesfor MMP12

Genomic Locationfor MMP12

Proteinsfor MMP12

Protein Domains/Familiesfor MMP12

Gene Functionfor MMP12

Pathways & Interactionsfor MMP12

Drugs & Compoundsfor MMP12

Transcriptsfor MMP12

Expression for MMP12

Orthologsfor MMP12

Paralogsfor MMP12

SNPs/Variantsfor MMP12

Disorders & Mutationsfor MMP12

Medical Newsfor MMP12

Publicationsfor MMP12

Search for MMP12

Genome Databases showing MMP12

Other Databases showing MMP12

Specialized Databases showing MMP12

Licensable Technologiesfor MMP12

Servicesfor MMP12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MMP12

Summaries
for MMP12

Genomic Location
for MMP12

Proteins
for MMP12

Protein Domains/
Families
for MMP12

Gene Function
for MMP12

Pathways & Interactions
for MMP12

Drugs & Compounds
for MMP12

Transcripts
for MMP12

Expression
for MMP12

Orthologs
for MMP12

Paralogs
for MMP12

SNPs/Variants
for MMP12

Disorders & Mutations
for MMP12

Medical News
for MMP12

Publications
for MMP12

Licensable Technologies
for MMP12

Services
for MMP12