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MMP11 Gene

protein-coding GIFtS: 69
GCID: GC22P024110

Matrix Metallopeptidase 11 (Stromelysin 3)

(Previous name: matrix metalloproteinase 11 (stromelysin 3))
(Previous symbol: STMY3)

See MMP11-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Matrix Metallopeptidase 11 (Stromelysin 3)¹ ²		Stromelysin III²
STMY3¹ ² ³ ⁵		stromelysin-3²
MMP-11² ³		EC 3.4.24.-³
SL-3² ³		Matrix Metalloproteinase-11³
ST3² ³		EC 3.4.24⁸
Matrix Metalloproteinase 11 (Stromelysin 3)¹		EC 3.4.24.24⁸

External Ids:	HGNC: 7157¹	Entrez Gene: 4320²	Ensembl: ENSG00000099953⁷	OMIM: 185261⁵	UniProtKB: P24347³

Export aliases for MMP11 gene to outside databases

Previous GC identifers: GC22P020811 GC22P022439 GC22P007103

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP11 Gene:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in

normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in

disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are

activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated

intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme

cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

(provided by RefSeq, Jul 2008)

GeneCards Summary for MMP11 Gene:

MMP11 (matrix metallopeptidase 11 (stromelysin 3)) is a protein-coding gene. Diseases associated with MMP11 include space motion sickness, and colorectal cancer. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Function: May play an important role in the progression of epithelial malignancies

summary for MMP11 Gene:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP11 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000022.10 NC_018933.2 NT_011520.13 NT_187633.1

Regulatory elements:

Regulatory transcription factor binding sites in the MMP11 gene promoter:
Egr-3 p53 p300 MZF-1 FOXJ2 (long isoform) HOXA5 ARP-1 FOXJ2 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for MMP11

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

MMP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP11 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P024110: view genomic region (about GC identifiers)

Start:	24,110,413 bp from pter	End:	24,126,503 bp from pter
Size:	16,091 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347 (See protein sequence)

Recommended Name: Stromelysin-3 precursor

Size: 488 amino acids; 54590 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Cofactor: Binds 2 zinc ions per subunit (By similarity)

Secondary accessions: Q5FX24 Q6PEZ6 Q9UC26

Explore the universe of human proteins at neXtProt for MMP11: NX_P24347

Explore proteomics data for MMP11 at MOPED

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for MMP11 (P24347) (see all 7)

PRCGVPD

VAAHEFGH

VWSDVTPL

KVWSDVTPL

See MMP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005931.2

ENSEMBL proteins:

ENSP00000215743 ENSP00000409860 ENSP00000408070 ENSP00000412107

Reactome Protein details: P24347

MMP11 Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MMP11 Protein
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	GenScript Custom Purified and Recombinant Proteins Services for MMP11
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MMP11
	Search eBioscience for Proteins for MMP11
	Search GeneTex for Proteins for MMP11
	antibodies-online proteins for MMP11 (9 products)
	antibodies-online peptides for MMP11

MMP11 Antibody Products:

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	Novus Biologicals MMP11 Antibodies
	Abcam antibodies for MMP11
	Cloud-Clone Corp. Antibodies for MMP11
	ThermoFisher Antibody for MMP11
	antibodies-online antibodies for MMP11 (92 products)

MMP11 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MMP11
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MMP11
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MMP11 Cloud-Clone Corp. CLIAs for MMP11
	Search eBioscience for ELISAs for MMP11
	antibodies-online kits for MMP11 (36 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: MMP11

Cell-surface protein and extracellular matrix metalloproteinases

Selected InterPro protein domains (see all 10):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A

IPR000585 Hemopexin-like_dom

IPR018486 Hemopexin_CS

Graphical View of Domain Structure for InterPro Entry P24347

ProtoNet protein and cluster: P24347

2 Blocks protein domains:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting

the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the

enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin repeats

Find genes that share domains with MMP11 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MMP11_HUMAN, P24347

Function: May play an important role in the progression of epithelial malignancies

Genatlas biochemistry entry for MMP11:

matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of

pancreatic carcinoma

Enzyme Numbers (IUBMB): EC 3.4.24.24² EC 3.4.24.-¹ EC 3.4.24²

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008237	metallopeptidase activity	--	--
GO:0008270	zinc ion binding	IEA	--

Find genes that share ontologies with MMP11 About GenesLikeMe

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp11):

cardiovascular system

homeostasis/metabolism

tumorigenesis

Find genes that share phenotypes with MMP11 About GenesLikeMe

Animal Models:
MGI mouse knock-out Mmp11^tm1Mrio for MMP11

genOway: Develop your customized and physiologically relevant rodent model for MMP11

miRNA Products:		miRTarBase miRNAs that target MMP11: hsa-mir-125a-5p (MIRT006905)

		Block miRNA regulation of human, mouse, rat MMP11 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MMP11 (see all 23):
		hsa-miR-125a-5p hsa-let-7d hsa-miR-125a-3p hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3150b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MMP11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MMP11
		Predesigned siRNA for gene silencing in human, mouse, rat MMP11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP11

Clone Products:		OriGene clones in human, mouse for MMP11 (see all 7) OriGene ORF clones in mouse, rat for MMP11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP11 (NM_005940)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP11
		Browse ESI BIO Cell Lines and PureStem Progenitors for MMP11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP11

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

MMP11_HUMAN, P24347: Secreted, extracellular space, extracellular matrix (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	4
golgi apparatus	4
plasma membrane	3
mitochondrion	2
nucleus	2
cytoskeleton	1
cytosol	1
lysosome	1
peroxisome	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005796	Golgi lumen	TAS	--
GO:0031012	extracellular matrix	IDA	18622425

Find genes that share ontologies with MMP11 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for MMP11 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Matrix Metalloproteinases

	Matrix Metalloproteinases	0.68			Activation of Matrix Metalloproteinases	0.37
	Inhibition of Matrix Metalloproteinases	0.68

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	0.43			Extracellular matrix organization	0.34
	Collagen degradation	0.43

Integrin Pathway

UPA-UPAR Pathway

0.56

Transendothelial Migration of Leukocytes

0.38

GPCR Pathway

Pancreatic Adenocarcinoma

0.59

Colorectal Cancer Metastasis

Colorectal Cancer Metastasis

Find genes that share SuperPaths with MMP11 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP11

	Inhibition of Matrix Metalloproteinases
	Colorectal Cancer Metastasis
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 BioSystems Pathway for MMP11

Matrix Metalloproteinases

3 Reactome Pathways for MMP11

	Degradation of the extracellular matrix
	Collagen degradation
	Activation of Matrix Metalloproteinases

Pathway & Disease-focused RT² Profiler PCR Arrays including MMP11:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Tumor Metastasis in human mouse rat

Interactions:

GeneGlobe Interaction Network for MMP11

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for MMP11 (P24347³ ENSP00000215743⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SERPINA1	P01009³, ENSP00000348068⁴	I2D: score=1 STRING: ENSP00000348068
PRPF40A	O75400³	I2D: score=1
FURIN	ENSP00000268171⁴	STRING: ENSP00000268171
MMP1	ENSP00000322788⁴	STRING: ENSP00000322788
MMP2	ENSP00000219070⁴	STRING: ENSP00000219070

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	1701851
GO:0007275	multicellular organismal development	IEA	--
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030199	collagen fibril organization	IEA	--

Find genes that share ontologies with MMP11 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for MMP11 available from Tocris Bioscience About this table

Compound	Action	CAS #
GI 254023X	Selective ADAM10 metalloprotease inhibitor	[260264-93-5]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
GM 6001	Broad-spectrum MMP inhibitor	[142880-36-2]
UK 383367	Potent and selective BMP-1 (PCP) inhibitor	[348622-88-8]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]

1 HMDB Compound for MMP11 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 DrugBank Compounds for MMP11 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid	--	--	target	--	17139284 17016423 10592235
Marimastat	--	154039-60-8	target	antagonist	10852638 10669951

Selected Novoseek inferred chemical compound relationships for MMP11 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	24.8	9	9111003 (3), 7657606 (2), 7664289 (1), 9824353 (1)
12-o-tetradecanoylphorbol 13-acetate	24.2	5	10601280 (2), 10449779 (1)
paraffin	22.7	6	12429794 (1), 9499447 (1), 15788677 (1), 11753972 (1)
progesterone	13.5	3	15239838 (1), 19914229 (1)
oxygen	1.95	1	11254383 (1)
oligonucleotide	0	1	9550265 (1)
steroid	0	1	12529417 (1)
zinc	0	5	7559421 (2), 9446583 (1), 16946011 (1)
proline	0	2	11254383 (1), 12738779 (1)
serine	0	2	7523394 (1), 10049948 (1)

Find genes that share compounds with MMP11 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for MMP11 gene:

NM_005940.3

Unigene Cluster for MMP11:

Matrix metallopeptidase 11 (stromelysin 3)

Hs.143751 [show with all ESTs]

Unigene Representative Sequence: NM_005940

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465385 ENST00000477567 ENST00000489582 ENST00000215743(uc002zxx.3)

ENST00000465730 ENST00000428253 ENST00000437086(uc002zxy.3) ENST00000460352

ENST00000434318 ENST00000493132 ENST00000492464 ENST00000488363 ENST00000480185

miRNA Products:		Block miRNA regulation of human, mouse, rat MMP11 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MMP11 (see all 23):
		hsa-miR-125a-5p hsa-let-7d hsa-miR-125a-3p hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3150b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MMP11 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: MMP11 (NM_005940)
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MMP11
		QuantiTect SYBR Green Assays in human, mouse, rat MMP11
		QuantiFast Probe-based Assays in human, mouse, rat MMP11

Additional mRNA sequence:

AK075448.1 AK129792.1 BC057788.1 DQ399599.1 X57766.1

22 DOTS entries:

DT.95373912 DT.91781698 DT.100696344 DT.95286692 DT.75109588 DT.95252713 DT.120634191 DT.75151508

DT.40299587 DT.100798588 DT.100798589 DT.40123967 DT.95286578 DT.100715072 DT.120634200 DT.120634331

DT.120634203 DT.120634265 DT.120634313 DT.87077942 DT.95216912 DT.100645769

Selected AceView cDNA sequences (see all 341):

AI923616 AI123521 AI742579 CR612686 H02383 BI520017 R27452 CR624369

AK075448 H12885 R28596 AK125911 AK129792 BF111856 AI554159 AI126136

AI126404 BC057788 AI743259 R35443 AI188464 BX091060 AW292628 AI057119

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b
SP1:							-		-																-		-		-		-
SP2:									-																-		-		-
SP3:																									-		-		-
SP4:																									-
SP5:			-						-

ECgene alternative splicing isoforms for MMP11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGGAGACCC

About this image

MMP11 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Placenta (Extraembryonic Tissues) fully expand to see all 2 entries
Placenta-derived mesenchymal stem cells (family)

Neural Tube (Nervous System) fully expand to see all 2 entries
Floor Plate Cells Spinal Floor Plate
Spinal Floor Plate

Mesenchymal Stem Cells (Uncategorized) fully expand to see all 2 entries
Placenta-derived mesenchymal stem cells (family)

Brain (Nervous System) fully expand to see all 2 entries
Cerebral Cortex

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

MMP11 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MMP11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.143751

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Tissue specificity: Specifically expressed in stromal cells of breast carcinomas

Pathway & Disease-focused RT² Profiler PCR Arrays including MMP11:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Tumor Metastasis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for MMP11 OriGene qSTAR qPCR primer pairs in human, mouse for MMP11
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MMP11
		QuantiTect SYBR Green Assays in human, mouse, rat MMP11
		QuantiFast Probe-based Assays in human, mouse, rat MMP11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MMP11 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Mmp11^{1 , 5}	matrix metallopeptidase 11^{1, 5}	83.01(n)¹ 84.03(a)¹	10 (38.62 cM)⁵ 17385¹ NM_008606.2¹ NP_032632.1¹ 75923222⁵
chicken (Gallus gallus)	Aves	LOC101751203¹	stromelysin-3-like	68.42(n) 67.76(a)	101751203 XM_004934502.1 XP_004934559.1
African clawed frog (Xenopus laevis)	Amphibia	MGC64247²	hypothetical protein MGC64247	73.23(n)	Z27093.1
zebrafish (Danio rerio)	Actinopterygii	mmp11a¹	matrix metallopeptidase 11a	62.04(n) 60.88(a)	563753 XM_687113.6 XP_692205.6
fruit fly (Drosophila melanogaster)	Insecta	Mmp1³	tracheal system development (sensu Insecta) metalloendopeptidase	39(a) (best of 2)	--

ENSEMBL Gene Tree for MMP11 (if available)
TreeFam Gene Tree for MMP11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for MMP11 gene

MMP20² MMP13² MMP8² MMP14² MMP25² MMP16² MMP7² MMP24²

MMP15² MMP3² MMP27² MMP17² MMP10² MMP1²

16 SIMAP similar genes for MMP11 using alignment to 6 protein entries: MMP11_HUMAN (see all proteins):

MMP26 MMP7 MMP1 MMP24 MMP17 MMP13

MMP3 MMP14 MMP10 MMP16 MMP12 MMP19

MMP20 MMP25 MMP15 mmp20

Find genes that share paralogs with MMP11 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036140⁴		A colorectal cancer sample⁴	--	see VAR_036140	2	D N	mis⁴		0	--	--	--	--
rs377316246^1,2	C	--	7112460(+)	`CTCTCC/TGGCAG`	1	--	int¹		0	--	--	--	--
rs200525797^1,2	C	--	7112461(+)	`TCTCCA/GGCAGG`	1	--	int¹		0	--	--	--	--
rs62642534^1,2	C,F	--	7112512(+)	`GGCCCC/TGCACC`	2	P	syn¹		3		NS WA NA	4740
rs144421847^1,2	C	--	7112521(+)	`CCCCTC/TACCGA`	2	L	syn¹		1		NA	4542
rs28382569^1,2	C,F,H	--	7112524(+)	`CTCACA/C/TGAGCT`	3	T	syn¹ ese³		13		NS NA WA	5690
rs201283473^1,2		--	7112545(+)	`AGGTTC/TCCGGT`	2	F	syn¹		0	--	--	--	--
rs139334604^1,2	C	--	7112639(+)	`CCCGGA/CGTGTA`	2	S R	mis¹		0	--	--	--	--
rs145685781^1,2		--	7112886(+)	`GTGCTA/GCATTC`	1	--	int¹		0	--	--	--	--
rs2070455^1,2	C,F,A,H	--	7112895(+)	`TCCATG/ATTGCA`	1	--	int¹		22		NS EA NA WA CSA	1155

HapMap Linkage Disequilibrium report for MMP11 (24110413 - 24126503 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for MMP11: About this table

Variant ID	Type	Subtype	PubMed ID
esv2724041	CNV	Deletion	23290073
nsv914597	CNV	Loss	21882294
nsv526567	CNV	Gain	19592680
dgv4906n71	CNV	Gain	21882294
nsv7350	OTHER	Inversion	18451855

1 Site Specific Mutation Identification with PCR Assay for MMP11:

Cosmic Id	AA Change
110536	p.R70L

SeqTarget long-range PCR primers for resequencing MMP11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 185261 OMIM disorders: --

5 diseases for MMP11:
About MalaCards

space motion sickness colorectal cancer arthritis cutaneous fibrous histiocytoma

motion sickness

3 inferred disease relationships from the University of Copenhagen DISEASES database for MMP11:

Breast cancer Cutaneous fibrous histiocytoma Space motion sickness

Find genes that share disorders with MMP11 About GenesLikeMe

Selected Novoseek inferred disease relationships for MMP11 gene (see all 45) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	64.3	53	8446598 (4), 9502414 (3), 11753972 (3), 7518738 (3) (see all 22)
carcinoma	59.2	120	7657519 (5), 9099978 (4), 11193473 (4), 8645587 (3) (see all 47)
dermatofibroma	57.2	10	11862177 (4), 8757754 (2), 9699179 (1), 10233668 (1) (see all 5)
metastasis	55.4	42	18476627 (4), 15459498 (3), 11193473 (3), 11250937 (2) (see all 20)
tumors	52.9	160	8621777 (5), 7657519 (4), 7518738 (4), 19914229 (4) (see all 73)
pathological processes	52.4	5	15780176 (1), 19212658 (1), 10887496 (1)
breast cancer	51.6	62	9335457 (3), 17233884 (3), 19914229 (3), 7591307 (2) (see all 34)
carcinoma basal cell	49.1	22	1342967 (4), 8757754 (3), 8297480 (2), 11701402 (2) (see all 8)
invasive cancer	46.1	9	9499447 (3), 7677979 (1), 18622425 (1), 7518738 (1) (see all 5)
cancer	45.8	98	14522908 (4), 18979628 (4), 16322233 (4), 19509157 (3) (see all 36)

Genetic Association Database (GAD): MMP11
Human Genome Epidemiology (HuGE) Navigator: MMP11 (9 documents)

Export disorders for MMP11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP11 gene, integrated from 10 sources (see all 264):
(articles sorted by number of sources associating them with MMP11)

Structure and promoter characterization of the human stromelysin-3 gene. (PubMed id 7657606)^{1, 2, 3, 9} Anglard P.... Basset P. (J. Biol. Chem. 1995)
Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PubMed id 1639418)^{1, 3, 9} Levy A....Basset P. (Genomics 1992)
Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PubMed id 7746327)^{1, 2, 9} Pei D. and Weiss S.J. (Nature 1995)
Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. (PubMed id 20230842)^{1, 4} Ban J.Y....Chung J.H. (Life Sci. 2010)
Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)^{1, 4} Nalpas B....Abel L. (Gut 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase. (PubMed id 12006591)^{1, 3} Luo D....Anglard P. (J. Biol. Chem. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4320	HGNC: 7157	AceView: MMP11	Ensembl:ENSG00000099953	euGenes: HUgn4320
ECgene: MMP11	H-InvDB: MMP11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MMP11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP11	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp11/

Intellectual Property for MMP11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP11 gene:
Search GeneIP for patents involving MMP11

GeneCards and IP:
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MMP11 Gene

Matrix Metallopeptidase 11 (Stromelysin 3)

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BREAST CARCINOMA
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ESOPHAGEAL CARCINOMA
Dermatofibroma
Adenomatous Polyps
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dysplasia
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MMP11 Gene

Matrix Metallopeptidase 11 (Stromelysin 3)

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