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MMP11 Gene

protein-coding   GIFtS: 69
GCID: GC22P024110

Matrix Metallopeptidase 11 (Stromelysin 3)

(Previous name: matrix metalloproteinase 11 (stromelysin 3))
(Previous symbol: STMY3)
  See MMP11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 11 (Stromelysin 3)1 2     Stromelysin III2
STMY31 2 3 5     stromelysin-32
MMP-112 3     EC 3.4.24.-3
SL-32 3     Matrix Metalloproteinase-113
ST32 3     EC 3.4.248
Matrix Metalloproteinase 11 (Stromelysin 3)1     EC 3.4.24.248

External Ids:    HGNC: 71571   Entrez Gene: 43202   Ensembl: ENSG000000999537   OMIM: 1852615   UniProtKB: P243473   

Export aliases for MMP11 gene to outside databases

Previous GC identifers: GC22P020811 GC22P022439 GC22P007103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP11 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated
intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme
cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MMP11 Gene:
MMP11 (matrix metallopeptidase 11 (stromelysin 3)) is a protein-coding gene. Diseases associated with MMP11 include space motion sickness, and motion sickness. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347
Function: May play an important role in the progression of epithelial malignancies

summary for MMP11 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  NT_187633.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP11 gene promoter:
         Egr-3   p53   p300   MZF-1   FOXJ2 (long isoform)   HOXA5   ARP-1   FOXJ2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MMP11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

MMP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024110:  view genomic region     (about GC identifiers)

Start:
24,110,413 bp from pter      End:
24,126,503 bp from pter
Size:
16,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347 (See protein sequence)
Recommended Name: Stromelysin-3 precursor  
Size: 488 amino acids; 54590 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Secondary accessions: Q5FX24 Q6PEZ6 Q9UC26

Explore the universe of human proteins at neXtProt for MMP11: NX_P24347

Explore proteomics data for MMP11 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP11 (P24347) (see all 7)
     PRCGVPD  VAAHEFGH  VWSDVTPL  KVWSDVTPL 


    See MMP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005931.2  
    ENSEMBL proteins: 
     ENSP00000215743   ENSP00000409860   ENSP00000408070   ENSP00000412107  
    Reactome Protein details: P24347

    MMP11 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MMP11 Protein
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    Enzo Life Sciences proteins for MMP11
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MMP11
    GenScript Custom Purified and Recombinant Proteins Services for MMP11
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP11

     
    Search eBioscience for Proteins for MMP11 

    MMP11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MMP11 (MMP-11)
    OriGene Antibodies for MMP11
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    Novus Biologicals MMP11 Antibodies
    Abcam antibodies for MMP11
    Cloud-Clone Corp. Antibodies for MMP11
    ThermoFisher Antibody for MMP11
    LSBio Antibodies in human, mouse, rat for MMP11

    MMP11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMP11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MMP11
    Cloud-Clone Corp. CLIAs for MMP11
    Search eBioscience for ELISAs for MMP11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP11
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 10):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P24347

    ProtoNet protein and cluster: P24347

    2 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin


    UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP11_HUMAN, P24347
    Function: May play an important role in the progression of epithelial malignancies

         Genatlas biochemistry entry for MMP11:
    matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of
    pancreatic carcinoma

         Enzyme Numbers (IUBMB): EC 3.4.24.242 EC 3.4.24.-1 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP11           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp11):
     cardiovascular system  homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with MMP11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmp11tm1Mrio for MMP11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP11:
    hsa-mir-125a-5p (MIRT006905)

    Block miRNA regulation of human, mouse, rat MMP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP11 (see all 23):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-125a-3p hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP11
    Predesigned siRNA for gene silencing in human, mouse, rat MMP11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP11

    Clone
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    OriGene clones in human, mouse for MMP11 (see all 7)
    OriGene ORF clones in mouse, rat for MMP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP11 (NM_005940)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP11

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MMP11
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMP11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP11_HUMAN, P24347: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus4
    plasma membrane3
    mitochondrion2
    nucleus2
    cytoskeleton1
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0031012extracellular matrix IDA18622425

    Find genes that share ontologies with MMP11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP11 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    3Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    5Colorectal Cancer Metastasis
    Colorectal Cancer Metastasis


    Find genes that share SuperPaths with MMP11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP11
        Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 BioSystems Pathway for MMP11
        Matrix Metalloproteinases

    3 Reactome Pathways for MMP11
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP11: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MMP11 (P243473 ENSP000002157434) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    PRPF40AO754003I2D: score=1 
    FURINENSP000002681714STRING: ENSP00000268171
    MMP1ENSP000003227884STRING: ENSP00000322788
    MMP2ENSP000002190704STRING: ENSP00000219070
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS1701851
    GO:0007275multicellular organismal development IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--

    Find genes that share ontologies with MMP11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MMP11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for MMP11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid-- --target--17139284 17016423 10592235
    Marimastat-- 154039-60-8targetantagonist10852638 10669951

    Selected Novoseek inferred chemical compound relationships for MMP11 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 24.8 9 9111003 (3), 7657606 (2), 7664289 (1), 9824353 (1)
    12-o-tetradecanoylphorbol 13-acetate 24.2 5 10601280 (2), 10449779 (1)
    paraffin 22.7 6 12429794 (1), 9499447 (1), 15788677 (1), 11753972 (1)
    progesterone 13.5 3 15239838 (1), 19914229 (1)
    oxygen 1.95 1 11254383 (1)
    oligonucleotide 0 1 9550265 (1)
    steroid 0 1 12529417 (1)
    zinc 0 5 7559421 (2), 9446583 (1), 16946011 (1)
    proline 0 2 11254383 (1), 12738779 (1)
    serine 0 2 7523394 (1), 10049948 (1)



    Find genes that share compounds with MMP11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP11 gene: 
    NM_005940.3  

    Unigene Cluster for MMP11:

    Matrix metallopeptidase 11 (stromelysin 3)
    Hs.143751  [show with all ESTs]
    Unigene Representative Sequence: NM_005940
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465385 ENST00000477567 ENST00000489582 ENST00000215743(uc002zxx.3)
    ENST00000465730 ENST00000428253 ENST00000437086(uc002zxy.3) ENST00000460352
    ENST00000434318 ENST00000493132 ENST00000492464 ENST00000488363 ENST00000480185

    miRNA
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    Block miRNA regulation of human, mouse, rat MMP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMP11 (see all 23):
    hsa-miR-125a-5p hsa-let-7d hsa-miR-125a-3p hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMMP11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MMP11
    Clone
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    GenScript: all cDNA clones in your preferred vector: MMP11 (NM_005940)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP11
    Primer
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    OriGene qPCR primer pairs and template standards for MMP11
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP11
      QuantiTect SYBR Green Assays in human, mouse, rat MMP11
      QuantiFast Probe-based Assays in human, mouse, rat MMP11

    Additional mRNA sequence: 

    AK075448.1 AK129792.1 BC057788.1 DQ399599.1 X57766.1 

    22 DOTS entries:

    DT.95373912  DT.91781698  DT.100696344  DT.95286692  DT.75109588  DT.95252713  DT.120634191  DT.75151508 
    DT.40299587  DT.100798588  DT.100798589  DT.40123967  DT.95286578  DT.100715072  DT.120634200  DT.120634331 
    DT.120634203  DT.120634265  DT.120634313  DT.87077942  DT.95216912  DT.100645769 

    Selected AceView cDNA sequences (see all 341):

    AI923616 AI123521 AI742579 CR612686 H02383 BI520017 R27452 CR624369 
    AK075448 H12885 R28596 AK125911 AK129792 BF111856 AI554159 AI126136 
    AI126404 BC057788 AI743259 R35443 AI188464 BX091060 AW292628 AI057119 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                    -     -                                               -     -     -     -                     
    SP2:                          -                                               -     -     -                           
    SP3:                                                                          -     -     -                           
    SP4:                                                                          -                                       
    SP5:        -                 -                                                                                       


    ECgene alternative splicing isoforms for MMP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MMP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAGACCC
    MMP11 Expression
    About this image


    MMP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Floor Plate Cells Spinal Floor Plate
             Spinal Floor Plate
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    MMP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143751

    UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347
    Tissue specificity: Specifically expressed in stromal cells of breast carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP11: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMP11 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp111 , 5 matrix metallopeptidase 111, 5 83.01(n)1
    84.03(a)1
      10 (38.62 cM)5
    173851  NM_008606.21  NP_032632.11 
     759232225 
    chicken
    (Gallus gallus)
    Aves LOC1017512031 stromelysin-3-like 68.42(n)
    67.76(a)
      101751203  XM_004934502.1  XP_004934559.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642472 hypothetical protein MGC64247 73.23(n)    Z27093.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmp11a1 matrix metallopeptidase 11a 62.04(n)
    60.88(a)
      563753  XM_687113.6  XP_692205.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mmp13 tracheal system development (sensu
    Insecta) metalloendopeptidase
    39(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for MMP11 (if available)
    TreeFam Gene Tree for MMP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP11 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP272  MMP172  MMP102  MMP12  
    16 SIMAP similar genes for MMP11 using alignment to 6 protein entries:     MMP11_HUMAN (see all proteins):
    MMP26    MMP7    MMP1    MMP24    MMP17    MMP13
    MMP3    MMP14    MMP10    MMP16    MMP12    MMP19
    MMP20    MMP25    MMP15    mmp20

    Find genes that share paralogs with MMP11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP11 (see all 358)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361404
    A colorectal cancer sample4--see VAR_0361402 D N mis40--------
    rs3773162461,2
    C--7112460(+) CTCTCC/TGGCAG 1 -- int10--------
    rs2005257971,2
    C--7112461(+) TCTCCA/GGCAGG 1 -- int10--------
    rs626425341,2
    C,F--7112512(+) GGCCCC/TGCACC 2 P syn13Minor allele frequency- T:0.00NS WA NA 4740
    rs1444218471,2
    C--7112521(+) CCCCTC/TACCGA 2 L syn11Minor allele frequency- T:0.00NA 4542
    rs283825691,2
    C,F,H--7112524(+) CTCACA/C/TGAGCT 3 T syn1 ese313NS NA WA 5690
    rs2012834731,2
    --7112545(+) AGGTTC/TCCGGT 2 F syn10--------
    rs1393346041,2
    C--7112639(+) CCCGGA/CGTGTA 2 S R mis10--------
    rs1456857811,2
    --7112886(+) GTGCTA/GCATTC 1 -- int10--------
    rs20704551,2
    C,F,A,H--7112895(+) TCCATG/ATTGCA 1 -- int122Minor allele frequency- A:0.17NS EA NA WA CSA 1155

    HapMap Linkage Disequilibrium report for MMP11 (24110413 - 24126503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MMP11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    nsv914597CNV Loss21882294
    nsv526567CNV Gain19592680
    dgv4906n71CNV Gain21882294
    nsv7350OTHER Inversion18451855

    1 Site Specific Mutation Identification with PCR Assay for MMP11:
    Cosmic IdAA Change
    110536p.R70L
    SeqTarget long-range PCR primers for resequencing MMP11
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185261    OMIM disorders: --

    5 diseases for MMP11:    
    About MalaCards
    space motion sickness    motion sickness    cutaneous fibrous histiocytoma    arthritis
    colorectal cancer

    3 diseases from the University of Copenhagen DISEASES database for MMP11:
    Breast cancer     Cutaneous fibrous histiocytoma     Space motion sickness

    Find genes that share disorders with MMP11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MMP11 gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 64.3 53 8446598 (4), 9502414 (3), 11753972 (3), 7518738 (3) (see all 22)
    carcinoma 59.2 120 7657519 (5), 9099978 (4), 11193473 (4), 8645587 (3) (see all 47)
    dermatofibroma 57.2 10 11862177 (4), 8757754 (2), 9699179 (1), 10233668 (1) (see all 5)
    metastasis 55.4 42 18476627 (4), 15459498 (3), 11193473 (3), 11250937 (2) (see all 20)
    tumors 52.9 160 8621777 (5), 7657519 (4), 7518738 (4), 19914229 (4) (see all 73)
    pathological processes 52.4 5 15780176 (1), 19212658 (1), 10887496 (1)
    breast cancer 51.6 62 9335457 (3), 17233884 (3), 19914229 (3), 7591307 (2) (see all 34)
    carcinoma basal cell 49.1 22 1342967 (4), 8757754 (3), 8297480 (2), 11701402 (2) (see all 8)
    invasive cancer 46.1 9 9499447 (3), 7677979 (1), 18622425 (1), 7518738 (1) (see all 5)
    cancer 45.8 98 14522908 (4), 18979628 (4), 16322233 (4), 19509157 (3) (see all 36)

    Genetic Association Database (GAD): MMP11
    Human Genome Epidemiology (HuGE) Navigator: MMP11 (9 documents)

    Export disorders for MMP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP11 gene, integrated from 10 sources (see all 264):
    (articles sorted by number of sources associating them with MMP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and promoter characterization of the human stromelysin-3 gene. (PubMed id 7657606)1, 2, 3, 9 Anglard P.... Basset P. (J. Biol. Chem. 1995)
    2. Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PubMed id 1639418)1, 3, 9 Levy A....Basset P. (Genomics 1992)
    3. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PubMed id 7746327)1, 2, 9 Pei D. and Weiss S.J. (Nature 1995)
    4. Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. (PubMed id 20230842)1, 4 Ban J.Y....Chung J.H. (Life Sci. 2010)
    5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase. (PubMed id 12006591)1, 3 Luo D....Anglard P. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4320 HGNC: 7157 AceView: MMP11 Ensembl:ENSG00000099953 euGenes: HUgn4320
    ECgene: MMP11 H-InvDB: MMP11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP11 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP11 gene:
    Search GeneIP for patents involving MMP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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