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MMP11 Gene(Protein Coding)

Matrix Metallopeptidase 11

GCID:
GC22P023768
GIFtS:
66
Genes Participants
UDN Logo

Aliases for MMP11 Gene

Aliases for MMP11 Gene

  • Matrix Metallopeptidase 11 2 3 5
  • STMY3 3 4
  • SL-3 3 4
  • ST3 3 4
  • Matrix Metalloproteinase 11 (Stromelysin 3) 2
  • Matrix Metallopeptidase 11 (Stromelysin 3) 3
  • Matrix Metalloproteinase-11 4
  • Stromelysin III 3
  • Stromelysin 3 2
  • Stromelysin-3 3
  • EC 3.4.24.24 61
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • MMP-11 4

External Ids for MMP11 Gene

Previous HGNC Symbols for MMP11 Gene

  • STMY3

Previous GeneCards Identifiers for MMP11 Gene

  • GC22P020811
  • GC22P022439
  • GC22P024110
  • GC22P007103

Summaries for MMP11 Gene

Entrez Gene Summary for MMP11 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP11 Gene

MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Basal Cell Carcinoma and Colorectal Cancer. Among its related pathways are GPCR Pathway and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.

UniProtKB/Swiss-Prot for MMP11 Gene

  • May play an important role in the progression of epithelial malignancies.

Tocris Summary for MMP11 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP11 Gene

Genomics for MMP11 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MMP11 Gene

Enhancers for MMP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F023821 1 FANTOM5 ENCODE 26.9 +56.7 56722 6.1 ZNF263 ZNF362 RFX1 KLF1 ZNF384 ZIC2 OSR2 SMARCA4 POLR2A SCRT2 SMARCB1 MMP11 CHCHD10 VPREB3 ZNF70 C22orf15 ENSG00000234353 DERL3 SLC2A11
GH22F023833 1 ENCODE 24.4 +69.2 69159 6.9 PKNOX1 ATF1 CREB3L1 SIN3A DMAP1 FEZF1 ZNF2 GLIS2 ZNF143 ZNF207 SMARCB1 MMP11 CHCHD10 ZNF70 SNRPD3 ENSG00000234353 DRICH1 VPREB3 DERL3 ENSG00000273295
GH22F024548 1.8 FANTOM5 Ensembl ENCODE 10.9 +785.2 785236 8.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF70 SNRPD3 GGTLC4P POM121L9P MIF-AS1 ARL5AP4 LOC100421614 CRIP1P4 RPS10P29 ENSG00000228039
GH22F023804 0.8 ENCODE 23.6 +37.4 37440 1.8 HDGF ELF3 MXI1 ZNF76 ZNF324 ZFHX2 POLR2A PATZ1 CREM EGR2 MMP11 CHCHD10 SMARCB1 C22orf15 SLC2A11 ENSG00000251357 RN7SL268P MIF GUSBP11 MIF-AS1
GH22F023518 1.6 FANTOM5 Ensembl ENCODE 11.4 -246.7 -246661 6.4 PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF48 ZNF121 GLIS2 ZNF143 FOS ENSG00000225413 MMP11 GGTLC4P RGL4 GUSBP11 ENSG00000227755 DDT LINC01659 ENSG00000272787 RSPH14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP11 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MMP11 gene promoter:

Genomic Location for MMP11 Gene

Chromosome:
22
Start:
23,768,226 bp from pter
End:
23,784,316 bp from pter
Size:
16,091 bases
Orientation:
Plus strand

Genomic View for MMP11 Gene

Genes around MMP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MMP11 Gene

Proteins for MMP11 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MMP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24347-MMP11_HUMAN
    Recommended name:
    Stromelysin-3
    Protein Accession:
    P24347
    Secondary Accessions:
    • Q5FX24
    • Q6PEZ6
    • Q9UC26

    Protein attributes for MMP11 Gene

    Size:
    488 amino acids
    Molecular mass:
    54590 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP11 Gene

Protein Expression for MMP11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MMP11 Gene

P24347:
  • PRCGVPD
  • VWSDVTPL
  • GYPALASRHW
  • VAAHEFGH
  • FDAVSTIRGELFFFK
  • KVWSDVTPL
  • RNRQKRFVLSGGRW

Post-translational modifications for MMP11 Gene

Other Protein References for MMP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MMP11 Gene

Gene Families for MMP11 Gene

HGNC:
IUPHAR :

Protein Domains for MMP11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MMP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24347

UniProtKB/Swiss-Prot:

MMP11_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP11: view

Function for MMP11 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MMP11 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of pancreatic carcinoma
UniProtKB/Swiss-Prot Function:
May play an important role in the progression of epithelial malignancies.

Enzyme Numbers (IUBMB) for MMP11 Gene

Gene Ontology (GO) - Molecular Function for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP11: view
genes like me logo Genes that share phenotypes with MMP11: view

Animal Models for MMP11 Gene

MGI Knock Outs for MMP11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP11

miRNA for MMP11 Gene

miRTarBase miRNAs that target MMP11

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP11

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP11 Gene

Localization for MMP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP11 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA,IDA 18622425
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP11: view

Pathways & Interactions for MMP11 Gene

genes like me logo Genes that share pathways with MMP11: view

Gene Ontology (GO) - Biological Process for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organism development IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization IEA --
GO:0030199 collagen fibril organization IEA --
genes like me logo Genes that share ontologies with MMP11: view

No data available for SIGNOR curated interactions for MMP11 Gene

Drugs & Compounds for MMP11 Gene

Products:

  1. Drug

(13) Drugs for MMP11 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid Experimental Pharma Target 0
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0

(7) Additional Compounds for MMP11 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP11 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP11: view

Transcripts for MMP11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MMP11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(341) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP11 Gene

Matrix metallopeptidase 11 (stromelysin 3):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for MMP11 Gene

GeneLoc Exon Structure for
MMP11
ECgene alternative splicing isoforms for
MMP11

Expression for MMP11 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP11 Gene

mRNA expression in normal human tissues for MMP11 Gene
mRNA expression by BioGPS for MMP11 GenemRNA expression by GTEx for MMP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP11 Gene

This gene is overexpressed in Uterus (x8.9), Cervix - Endocervix (x6.1), and Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for MMP11 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP11 Gene



Protein tissue co-expression partners for MMP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP11 Gene:

MMP11

SOURCE GeneReport for Unigene cluster for MMP11 Gene:

Hs.143751

mRNA Expression by UniProt/SwissProt for MMP11 Gene:

P24347-MMP11_HUMAN
Tissue specificity: Specifically expressed in stromal cells of breast carcinomas.
genes like me logo Genes that share expression patterns with MMP11: view

Orthologs for MMP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MMP11 34 35
  • 99.04 (n)
dog
(Canis familiaris)
 Mammalia MMP11 34 35
  • 86.39 (n)
cow
(Bos Taurus)
 Mammalia MMP11 34 35
  • 85.22 (n)
mouse
(Mus musculus)
 Mammalia Mmp11 34 16 35
  • 83.01 (n)
rat
(Rattus norvegicus)
 Mammalia Mmp11 34
  • 82.82 (n)
oppossum
(Monodelphis domestica)
 Mammalia MMP11 35
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC101751203 34
  • 68.42 (n)
MMP11 35
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mmp11 34
  • 64.9 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC64247 34
zebrafish
(Danio rerio)
 Actinopterygii mmp11a 34 35
  • 62.04 (n)
mmp11b 35
  • 49 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Mmp1 36
  • 39 (a)
Mmp2 36 35
  • 39 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 28 (a)
 ManyToMany
Species where no ortholog for MMP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP11 Gene

ENSEMBL:
Gene Tree for MMP11 (if available)
TreeFam:
Gene Tree for MMP11 (if available)

Paralogs for MMP11 Gene

Paralogs for MMP11 Gene

(16) SIMAP similar genes for MMP11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MMP11: view

Variants for MMP11 Gene

Sequence variations from dbSNP and Humsavar for MMP11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036140 A colorectal cancer sample
rs10775767 -- 23,771,049(+) AAAAA(A/G)AAAAG intron-variant, upstream-variant-2KB
rs111343485 -- 23,773,050(+) CGGCG(C/G)ATCCG intron-variant
rs111350178 -- 23,784,268(+) TCTTC(-/T)TTTTT nc-transcript-variant, utr-variant-3-prime
rs111573963 -- 23,779,024(+) GCCAG(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP11 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for MMP11 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP11 Gene

Disorders for MMP11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MMP11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
basal cell carcinoma
  • basal cell cancer
colorectal cancer
  • colorectal cancer, somatic
breast cancer
  • breast cancer, invasive ductal
ophthalmomyiasis
  • ocular myiasis
aleutian mink disease
  • aleutian disease
- elite association - COSMIC cancer census association via MalaCards
Search MMP11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP11

Genetic Association Database (GAD)
MMP11
Human Genome Epidemiology (HuGE) Navigator
MMP11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP11
genes like me logo Genes that share disorders with MMP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP11 Gene

Publications for MMP11 Gene

  1. Structure and promoter characterization of the human stromelysin-3 gene. (PMID: 7657606) Anglard P. … Basset P. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PMID: 7746327) Pei D. … Weiss S.J. (Nature 1995) 3 4 22 64
  3. Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PMID: 1639418) Levy A. … Basset P. (Genomics 1992) 2 3 22 64
  4. Overexpression of matrix metalloproteinase 11 in human gastric carcinoma and its clinicopathologic significance. (PMID: 20060156) Zhao Z.S. … Tao H.Q. (Hum. Pathol. 2010) 3 22 64
  5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for MMP11 Gene

  • Addgene plasmids for MMP11

Sources for MMP11 Gene

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