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Aliases for MMP11 Gene

Aliases for MMP11 Gene

  • Matrix Metallopeptidase 11 2 3 5
  • STMY3 3 4
  • SL-3 3 4
  • ST3 3 4
  • Matrix Metalloproteinase 11 (Stromelysin 3) 2
  • Matrix Metallopeptidase 11 (Stromelysin 3) 3
  • Matrix Metalloproteinase-11 4
  • Stromelysin III 3
  • Stromelysin 3 2
  • Stromelysin-3 3
  • EC 3.4.24.24 58
  • EC 3.4.24.- 4
  • EC 3.4.24 58
  • MMP-11 4

External Ids for MMP11 Gene

Previous HGNC Symbols for MMP11 Gene

  • STMY3

Previous GeneCards Identifiers for MMP11 Gene

  • GC22P020811
  • GC22P022439
  • GC22P024110
  • GC22P007103

Summaries for MMP11 Gene

Entrez Gene Summary for MMP11 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP11 Gene

MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Space Motion Sickness and Aleutian Mink Disease. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.

UniProtKB/Swiss-Prot for MMP11 Gene

  • May play an important role in the progression of epithelial malignancies.

Tocris Summary for MMP11 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP11 Gene

Additional gene information for MMP11 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP11 Gene

Genomics for MMP11 Gene

Regulatory Elements for MMP11 Gene

Enhancers for MMP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H023833 1.3 ENCODE dbSUPER 24.4 +69.2 69159 6 PKNOX1 ATF1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF143 ZNF207 FOS SMARCB1 MMP11 CHCHD10 ZNF70 SNRPD3 ENSG00000272578 CABIN1 ENSG00000234353 DRICH1 VPREB3
GH22H023821 1.1 FANTOM5 ENCODE dbSUPER 26.9 +56.7 56722 6 OSR2 ZNF362 GLIS1 ZNF384 RCOR1 ZIC2 ZNF18 SMARCB1 MMP11 CHCHD10 ZNF70 VPREB3 C22orf15 ENSG00000234353 DERL3 SLC2A11
GH22H022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -836.1 -836116 10 HDGF PKNOX1 ATF1 GATA2 ZNF143 ATF7 RUNX3 MCM3 MCM5 ZC3H11A TOP3B MIF-AS1 IGLV5-52 ENSG00000272578 IGLV3-4 IGLV2-5 MMP11 ENSG00000234630 ZNF70 IGLC2
GH22H022901 1.1 ENCODE dbSUPER 21.5 -865.4 -865396 2 HNRNPUL1 TBL1XR1 RB1 BACH1 BMI1 EBF1 EGR1 POLR2A EED NFE2 ZNF70 MMP11 TOP3B MIF-AS1 IGLC2 IGLV3-4 IGLV2-5 IGLC7 IGLV10-54 IGLJ3
GH22H022816 1 Ensembl ENCODE 21.5 -948.0 -948021 7 HNRNPUL1 CTCF PKNOX1 ETV1 TSC22D4 YBX1 EBF1 PYGO2 RELA CTBP1 TOP3B MMP11 ZNF70 IGLV5-52 ENSG00000272578 ENSG00000234630 IGLV3-9 IGLV2-8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP11 on UCSC Golden Path with GeneCards custom track

Promoters for MMP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144285 -326 1801 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 SP3

Genomic Location for MMP11 Gene

Chromosome:
22
Start:
23,768,226 bp from pter
End:
23,784,316 bp from pter
Size:
16,091 bases
Orientation:
Plus strand

Genomic View for MMP11 Gene

Genes around MMP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP11 Gene

Proteins for MMP11 Gene

  • Protein details for MMP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24347-MMP11_HUMAN
    Recommended name:
    Stromelysin-3
    Protein Accession:
    P24347
    Secondary Accessions:
    • Q5FX24
    • Q6PEZ6
    • Q9UC26

    Protein attributes for MMP11 Gene

    Size:
    488 amino acids
    Molecular mass:
    54590 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP11 Gene

Selected DME Specific Peptides for MMP11 Gene

P24347:
  • PRCGVPD
  • VWSDVTPL
  • GYPALASRHW
  • VAAHEFGH
  • FDAVSTIRGELFFFK
  • KVWSDVTPL
  • RNRQKRFVLSGGRW

Post-translational modifications for MMP11 Gene

Other Protein References for MMP11 Gene

Antibody Products

Domains & Families for MMP11 Gene

Gene Families for MMP11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P24347

UniProtKB/Swiss-Prot:

MMP11_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP11: view

Function for MMP11 Gene

Molecular function for MMP11 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of pancreatic carcinoma
UniProtKB/Swiss-Prot Function:
May play an important role in the progression of epithelial malignancies.

Enzyme Numbers (IUBMB) for MMP11 Gene

Gene Ontology (GO) - Molecular Function for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP11: view
genes like me logo Genes that share phenotypes with MMP11: view

Animal Models for MMP11 Gene

MGI Knock Outs for MMP11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP11

CRISPR Products

miRNA for MMP11 Gene

miRTarBase miRNAs that target MMP11

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP11
  • Applied Biological Materials Clones for MMP11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP11 Gene

Localization for MMP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP11 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IDA,TAS 18622425
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP11 Gene

Pathways & Interactions for MMP11 Gene

genes like me logo Genes that share pathways with MMP11: view

Gene Ontology (GO) - Biological Process for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organism development IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization IEA --
GO:0030199 collagen fibril organization IEA --
genes like me logo Genes that share ontologies with MMP11: view

No data available for SIGNOR curated interactions for MMP11 Gene

Drugs & Compounds for MMP11 Gene

(13) Drugs for MMP11 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid Experimental Pharma Target 0
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0

(7) Additional Compounds for MMP11 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP11 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP11: view

Transcripts for MMP11 Gene

Unigene Clusters for MMP11 Gene

Matrix metallopeptidase 11 (stromelysin 3):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MMP11
  • Applied Biological Materials Clones for MMP11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for MMP11 Gene

GeneLoc Exon Structure for
MMP11
ECgene alternative splicing isoforms for
MMP11

Expression for MMP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP11 Gene

This gene is overexpressed in Uterus (x8.9), Cervix - Endocervix (x6.1), and Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for MMP11 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP11 Gene



Protein tissue co-expression partners for MMP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP11 Gene:

MMP11

SOURCE GeneReport for Unigene cluster for MMP11 Gene:

Hs.143751

mRNA Expression by UniProt/SwissProt for MMP11 Gene:

P24347-MMP11_HUMAN
Tissue specificity: Specifically expressed in stromal cells of breast carcinomas.

Evidence on tissue expression from TISSUES for MMP11 Gene

  • Intestine(2.3)
genes like me logo Genes that share expression patterns with MMP11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP11 Gene

Orthologs for MMP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP11 33 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia MMP11 33 34
  • 86.39 (n)
cow
(Bos Taurus)
Mammalia MMP11 33 34
  • 85.22 (n)
mouse
(Mus musculus)
Mammalia Mmp11 33 16 34
  • 83.01 (n)
rat
(Rattus norvegicus)
Mammalia Mmp11 33
  • 82.82 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP11 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751203 33
  • 68.42 (n)
MMP11 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp11 33
  • 64.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64247 33
zebrafish
(Danio rerio)
Actinopterygii mmp11a 33 34
  • 62.04 (n)
mmp11b 34
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 35
  • 39 (a)
Mmp2 35 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
ManyToMany
Species where no ortholog for MMP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP11 Gene

ENSEMBL:
Gene Tree for MMP11 (if available)
TreeFam:
Gene Tree for MMP11 (if available)

Paralogs for MMP11 Gene

genes like me logo Genes that share paralogs with MMP11: view

Variants for MMP11 Gene

Sequence variations from dbSNP and Humsavar for MMP11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036140 A colorectal cancer sample
rs1000194693 -- 23,777,549(+) CGATA(-/GAGC)GAGCG intron-variant
rs1000210893 -- 23,780,767(+) AAAGA(A/G)TGGGG intron-variant
rs1000885618 -- 23,772,748(+) CGCGG(C/T)TGCTA upstream-variant-2KB
rs1001071597 -- 23,771,682(+) GGCCT(C/T)CCAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP11 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for MMP11 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP11 Gene

Human Gene Mutation Database (HGMD)
MMP11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP11 Gene

Disorders for MMP11 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MMP11 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
space motion sickness
aleutian mink disease
  • aleutian disease
dermatofibrosarcoma protuberans
  • dfsp
cutaneous fibrous histiocytoma
  • benign cutaneous fibrous histiocytoma
dermis tumor
  • neoplasm of dermis
- elite association - COSMIC cancer census association via MalaCards
Search MMP11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP11

Genetic Association Database (GAD)
MMP11
Human Genome Epidemiology (HuGE) Navigator
MMP11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP11
genes like me logo Genes that share disorders with MMP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP11 Gene

Publications for MMP11 Gene

  1. Structure and promoter characterization of the human stromelysin-3 gene. (PMID: 7657606) Anglard P … Basset P (The Journal of biological chemistry 1995) 2 3 4 22 60
  2. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PMID: 7746327) Pei D … Weiss SJ (Nature 1995) 3 4 22 60
  3. Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PMID: 1639418) Levy A … Basset P (Genomics 1992) 2 3 22 60
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for MMP11 Gene

  • Addgene plasmids for MMP11

Sources for MMP11 Gene

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