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MMP11 Gene

protein-coding GIFtS: 66

GC22P022439

matrix metallopeptidase 11 (stromelysin 3)
(Previous name: matrix metalloproteinase 11 (stromelysin 3) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: STMY3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.24.- ^³
MMP-11 ^³
SL-3 ^², ³
ST3 ^², ³
STMY3 ^², ³, ⁵

Descriptions
Matrix metalloproteinase-11 ^³
matrix metallopeptidase 11 (stromelysin 3) ^²
matrix metalloproteinase 11 ^²
matrix metalloproteinase 11 (stromelysin 3) ^¹, ²
stromelysin 3 ^²
stromelysin III ^²

External Ids
HGNC: 7157¹
Entrez Gene: 4320²
UniProtKB: P24347³
Ensembl: ENSG00000099953⁷

Search outside databases for aliases for MMP11 gene

Previous GC identifer: GC22P020811

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MMP11:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of

extracellular matrix in normal physiological processes, such as embryonic development,

reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and

metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved

by extracellular proteinases. However, the enzyme encoded by this gene is activated

intracellularly by furin within the constitutive secretory pathway. Also in contrast to other

MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural

proteins of the extracellular matrix. [provided by RefSeq]

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Function: May play an important role in the progression of epithelial malignancies

Gene Wiki entry for MMP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MMP11 gene

Entrez Gene cytogenetic band: 22q11.2|22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

MMP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P022439: (about GC identifiers)

Start:	22,445,036 bp from pter
End:	22,456,503 bp from pter
Size:	11,468 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347 (See protein sequence)

Recommended Name: Stromelysin-3 precursor

Size: 488 amino acids; 54618 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Cofactor: Binds 2 zinc ions per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

Secondary accessions: Q5FX24 Q6PEZ6 Q9UC26

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005931.2

ENSEMBL proteins:

ENSP00000215743

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MMP11 Protein
	Sigma-Aldrich Proteins for MMP11
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MMP11)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	TAS	1701851

About this table

Antibodies for MMP11:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MMP11
	Sigma-Aldrich Antibodies for MMP11
	R&D Systems Antibodies for MMP11 (MMP-11)
	Antibodies from Abcam (MMP11), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for MMP11

Assays for MMP11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24347

ProtoNet protein and cluster: P24347

2 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005940

Applied Biosystems Silencer® siRNAs for MMP11

Sigma-Aldrich siRNA and siRNA Panels for MMP11

Sigma-Aldrich shRNA Panels and shRNA for MMP11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005940
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005940
untagged cDNA clone in CMV expression vector: NM_005940

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005940

UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347

Function: May play an important role in the progression of epithelial malignancies

Enzyme Number (IUBMB): EC 3.4.24.-

Genatlas biochemistry entry for MMP11:

matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial

cells of pancreatic carcinoma

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mmp11):

homeostasis/metabolism

tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	TAS	7746327
GO:0005509	calcium ion binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for MMP11 (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling
Bladder Cancer Signaling
HIF1&alpha

GeneDecks MMP11 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MMP11

5/21 Interacting proteins for MMP11 (ENSP00000215743³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ST3GAL4	ENSP00000239597³	STRING (score=.913)
MYB	ENSP00000339992³	STRING (score=.877)
EGF	ENSP00000265171³	STRING (score=.867)
TIMP1	ENSP00000218388³	STRING (score=.864)
CXCL12	ENSP00000363548³	STRING (score=.857)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	1701851
GO:0007275	multicellular organismal development	TAS	7746327
GO:0030574	collagen catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MMP11

Browse Small Molecules at Sigma-Aldrich

Compounds for MMP11 available from Tocris Bioscience

Compound	Action	CAS number
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

About this table

7 Novoseek chemical compound relationships for MMP11 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
12-o-tetradecanoylphorbol 13-acetate	25.41	5	10601280 (2), 10449779 (1)
progesterone	10.77	2	15239838 (1)
oxygen	2.05	1	11254383 (1)
oligonucleotide	0.00	1	9550265 (1)
steroid	0.00	1	12529417 (1)
zinc	0.00	5	7559421 (2), 9446583 (1), 16946011 (1)
proline	0.00	2	11254383 (1), 12738779 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MMP11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MMP11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005940

Sigma-Aldrich siRNA and siRNA Panels for MMP11

Sigma-Aldrich shRNA Panels and shRNA for MMP11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005940

REFSEQ mRNAs for MMP11 gene:

NM_005940.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005940

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005940
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005940
                                 untagged cDNA clone in CMV expression vector: NM_005940

Additional cDNA sequence:

AK075448.1 AK129792.1 BC057788.1 CR602252.1 CR612686.1 CR624369.1 CR626443.1 DQ399599.1

X57766.1

22 DOTS entries:

DT.95373912 DT.91781698 DT.100696344 DT.95252713 DT.95286692 DT.75109588 DT.40299587 DT.120634191

DT.75151508 DT.100798588 DT.100798589 DT.40123967 DT.95286578 DT.100715072 DT.120634200 DT.120634331

DT.120634203 DT.120634265 DT.120634313 DT.87077942 DT.95216912 DT.100645769

24/341 AceView cDNA sequences (see all 341 ):

AI554159 R27452 AK075448 R28596 AI123521 AI126404 AI923616 H02383

CR612686 AI126136 CR624369 BI520017 BF111856 H12885 AK129792 BC057788

AI742579 AK125911 BX451144 AA291560 BX410521 AI188464 AL133974 BU179465

highest scoring ESTs for MMP11:

X57766 AA336162 AI057119 AI199857 AI220657 AI337465 AK075448 AK129792 BC057788 BF475827

Unigene Cluster for MMP11:

Matrix metallopeptidase 11 (stromelysin 3)

Hs.143751 [show with all ESTs]

Unigene Representative Sequence: NM_005940

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b
SP1:							-		-																-		-		-		-
SP2:									-																-		-		-
SP3:																									-		-		-
SP4:																									-
SP5:			-						-

About this scheme

ECgene alternative splicing isoforms for MMP11

1 Ensembl transcript including schematic representation:

ENST00000215743

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MMP11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MMP11

¹ / ² / ³

5 probe-sets matching MMP11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38181_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X57766	1.00	1.00	1.00	1
203878_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005940	0.60	1.00	0.82	1
203876_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI761713	0.40	1.00	0.76	1
203878_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203876_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGGAGACCC

SOURCE GeneReport for Unigene cluster: Hs.143751
Expression variation in blood from EXPOLDB for MMP11
UniProtKB/Swiss-Prot: MMP11_HUMAN, P24347
Tissue specificity: Specifically expressed in stromal cells of breast carcinomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MMP11 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MMP11¹	--	matrix metallopeptidase 11 (stromelysin 3)	86.38(n) 87.47(a)	486408 XM_543534.2 XP_543534.2
chimpanzee (Pan troglodytes)	MMP11¹	--	matrix metallopeptidase 11 (stromelysin 3)	99.04(n) 99.34(a)	458701 XM_515022.2 XP_515022.2
cow (Bos taurus)	MMP11¹	--	matrix metallopeptidase 11 (stromelysin 3)	85.29(n) 85.81(a)	539109 XM_584877.3 XP_584877.3
rat (Rattus norvegicus)	Mmp11¹	--	matrix metallopeptidase 11	82.64(n) 83.81(a)	25481 NM_012980.1 NP_037112.1
mouse (Mus musculus)	Mmp11^{1, 5}	10 (40.90 cM)⁵	matrix metallopeptidase 11^{1, 5}	82.96(n)¹ 82.55(a)¹	17385¹ NM_008606.2¹ NP_032632.1¹ AF297645⁵ AK142169⁵ (see all 9)

About this table Species with no ortholog for MMP11

ENSEMBL Gene Tree for MMP11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MMP11 gene

MMP17² MMP25² MMP26²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/147 NCBI SNPs in MMP11 are shown (see all 147 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs738792^1,2	A,C,F,H	22451378(+)	`GGACGT/CCCACC`	1	V/A	mis¹ ese³		14		EA NA EU WA NS	2408
	rs131451^1,2	A,C,F,H	22443544(+)	`AACCCT/CGAAAA`	1	--	ng5¹		11		MN EU EA WA NS	926
--	rs6003877^1,2	A,C,F,H	22456853(+)	`atgcgG/Aacggg`	1	--	ng3¹		4		EU EA WA	390
--	rs5760011^1,2	A,C	22456854(+)	`tgcggA/Ccgggc`	1	--	ng3¹		0	--	--	--	--
--	rs8137555^1,2	C,F	22456307(+)	`GGGTAT/CTCTTC`	1	--	ut3¹		6		NS EA	366
--	rs10775767^1,2	A,C	22443236(+)	`AAAAAA/GAAAAG`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs8137733^1,2	C,F	22444436(+)	`gaatcG/Atttga`	1	--	ng5¹		5		NS	186
	rs28363607^1,2	F	22444157(+)	`ACTTCG/AGTCTA`	1	--	ng5¹		5		NS	186
--	rs28382579^1,2	F	22456547(+)	`ATGGG-/TGAGGC`	1	--	ng3¹		5		NS	178
--	rs28363609^1,2	F	22444349(+)	`ACCCC-/CATCTC`	1	--	ng5¹		5		NS	182

About this table

HapMap Linkage Disequilibrium images for MMP11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 185261

10/45 Novoseek disease relationships for MMP11 gene (see all 45 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	65.49	51	8446598 (4), 9502414 (3), 11753972 (3), 7518738 (3) (see all 22)
carcinoma	60.16	117	7657519 (5), 9099978 (4), 11193473 (4), 8645587 (3) (see all 46)
dermatofibroma	58.82	10	11862177 (4), 8757754 (2), 9699179 (1), 10233668 (1) (see all 5)
metastasis	54.62	41	18476627 (4), 15459498 (3), 11193473 (3), 11250937 (2) (see all 19)
tumors	52.49	145	8621777 (5), 7657519 (4), 7518738 (4), 9177406 (3) (see all 68)
breast cancer	51.23	58	9335457 (3), 17233884 (3), 7591307 (2), 9502414 (2) (see all 32)
carcinoma basal cell	50.89	22	1342967 (4), 8757754 (3), 8297480 (2), 11701402 (2) (see all 8)
pathological processes	49.97	5	15780176 (1), 19212658 (1), 10887496 (1)
invasive cancer	47.83	9	9499447 (3), 7677979 (1), 18622425 (1), 7518738 (1) (see all 5)
cancer	45.23	91	14522908 (4), 18979628 (4), 16322233 (4), 9335457 (2) (see all 34)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/226 PubMed articles for MMP11 gene (see all 226 ):

Structure and promoter characterization of the human stromelysin-3 gene. (PubMed id 7657606)^{1, 2, 3, 4} Anglard P....Basset P. (1995)
Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PubMed id 1639418)^{1, 2, 3} Levy A....Basset P. (1992)
Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PubMed id 7746327)^{1, 3, 4} Pei D. and Weiss S.J. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase. (PubMed id 12006591)^{2, 3} Luo D....Anglard P. (2002)
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. (PubMed id 1701851)^{3, 4} Basset P.... Chambon P. (1990)
Mutational analysis of the cleavage of the cancer-associated laminin receptor by stromelysin-3 reveals the contribution of flanking sequences to site recognition and cleavage efficiency. (PubMed id 19212658)^{1, 3} Fiorentino M....Shi Y.B. (2009)
Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway. (PubMed id 17233884)^{1, 3} Kasper G....Lehmann K.E. (2007)
Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis. (PubMed id 15788677)^{1, 3} Arora S....Ralhan R. (2005)
Stromelysin-3 is expressed by aggressive meningiomas. (PubMed id 11857311)^{1, 3} Perret A.G....Mosnier J.F. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4320	HGNC: 7157	AceView: MMP11	Ensembl:ENSG00000099953	euGenes: HUgn4320
ECgene: MMP11	H-InvDB: MMP11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MMP11	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp11/

Licensable Technologies for MMP11
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MMP11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MMP11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MMP11		Antibodies for MMP11
	Explore super-pooled esiRNAs		Proteins for MMP11
	Lentivirus-delivered shRNAs for MMP11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Antibodies
	Chimera RNAi (MMP11)
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	Custom Service for Rabbit Pab from Full-length Protein

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Tocris compounds for MMP11

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Antibodies for MMP11

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MMP11 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for MMP11

Summaries
for MMP11

Genomic Location
for MMP11

Proteins
for MMP11

Protein Domains/
Families
for MMP11

Gene Function
for MMP11

Pathways & Interactions
for MMP11

Drugs & Compounds
for MMP11

Transcripts
for MMP11

Expression
for MMP11

Orthologs
for MMP11

Paralogs
for MMP11

SNPs/Variants
for MMP11

Disorders & Mutations
for MMP11

Medical News
for MMP11

Publications
for MMP11

Search for MMP11

Genome Databases showing MMP11

Other Databases showing MMP11

Specialized Databases showing MMP11

Licensable Technologies
for MMP11

Services
for MMP11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MMP11 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor MMP11

Summariesfor MMP11

Genomic Locationfor MMP11

Proteinsfor MMP11

Protein Domains/Familiesfor MMP11

Gene Functionfor MMP11

Pathways & Interactionsfor MMP11

Drugs & Compoundsfor MMP11

Transcriptsfor MMP11

Expression for MMP11

Orthologsfor MMP11

Paralogsfor MMP11

SNPs/Variantsfor MMP11

Disorders & Mutationsfor MMP11

Medical Newsfor MMP11

Publicationsfor MMP11

Search for MMP11

Genome Databases showing MMP11

Other Databases showing MMP11

Specialized Databases showing MMP11

Licensable Technologiesfor MMP11

Servicesfor MMP11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MMP11

Summaries
for MMP11

Genomic Location
for MMP11

Proteins
for MMP11

Protein Domains/
Families
for MMP11

Gene Function
for MMP11

Pathways & Interactions
for MMP11

Drugs & Compounds
for MMP11

Transcripts
for MMP11

Expression
for MMP11

Orthologs
for MMP11

Paralogs
for MMP11

SNPs/Variants
for MMP11

Disorders & Mutations
for MMP11

Medical News
for MMP11

Publications
for MMP11

Licensable Technologies
for MMP11

Services
for MMP11