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Aliases for MMP11 Gene

Aliases for MMP11 Gene

  • Matrix Metallopeptidase 11 2 3
  • STMY3 3 4 6
  • MMP-11 3 4
  • SL-3 3 4
  • ST3 3 4
  • Matrix Metalloproteinase 11 (Stromelysin 3) 2
  • Matrix Metallopeptidase 11 (Stromelysin 3) 3
  • Matrix Metalloproteinase-11 4
  • Stromelysin III 3
  • Stromelysin 3 2
  • Stromelysin-3 3
  • EC 3.4.24.24 64
  • EC 3.4.24.- 4
  • EC 3.4.24 64

External Ids for MMP11 Gene

Previous Symbols for MMP11 Gene

  • STMY3

Summaries for MMP11 Gene

Entrez Gene Summary for MMP11 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP11 Gene

MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include space motion sickness and colorectal cancer. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP11 Gene

  • May play an important role in the progression of epithelial malignancies

Tocris Summary for MMP11 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP11 Gene

Genomics for MMP11 Gene

Genomic Location for MMP11 Gene

Start:
23,768,226 bp from pter
End:
23,784,316 bp from pter
Size:
16,091 bases
Orientation:
Plus strand

Genomic View for MMP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP11 Gene

Regulatory Elements for MMP11 Gene

Proteins for MMP11 Gene

  • Protein details for MMP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24347-MMP11_HUMAN
    Recommended name:
    Stromelysin-3
    Protein Accession:
    P24347
    Secondary Accessions:
    • Q5FX24
    • Q6PEZ6
    • Q9UC26

    Protein attributes for MMP11 Gene

    Size:
    488 amino acids
    Molecular mass:
    54590 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP11 Gene

Proteomics data for MMP11 Gene at MOPED

Selected DME Specific Peptides for MMP11 Gene

Post-translational modifications for MMP11 Gene

Other Protein References for MMP11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MMP11 Gene

UniProtKB/Swiss-Prot:

MMP11_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • P24347
Family:
  • Belongs to the peptidase M10A family.:
    • P24347
Similarity:
  • Contains 4 hemopexin repeats.:
    • P24347
genes like me logo Genes that share domains with MMP11: view

Function for MMP11 Gene

Molecular function for MMP11 Gene

GENATLAS Biochemistry: matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of pancreatic carcinoma
UniProtKB/Swiss-Prot Function: May play an important role in the progression of epithelial malignancies

Enzyme Numbers (IUBMB) for MMP11 Gene

Gene Ontology (GO) - Molecular Function for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP11: view
genes like me logo Genes that share phenotypes with MMP11: view

Animal Models for MMP11 Gene

MGI Knock Outs for MMP11:

miRNA for MMP11 Gene

miRTarBase miRNAs that target MMP11

No data available for Transcription Factor Targeting and HOMER Transcription for MMP11 Gene

Localization for MMP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP11 Gene COMPARTMENTS Subcellular localization image for MMP11 gene
Compartment Confidence
extracellular 4
golgi apparatus 4
plasma membrane 3
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IDA 18622425
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP11: view

Pathways for MMP11 Gene

genes like me logo Genes that share pathways with MMP11: view

Gene Ontology (GO) - Biological Process for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organismal development IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030199 collagen fibril organization IEA --
genes like me logo Genes that share ontologies with MMP11: view

Compounds for MMP11 Gene

(5) Tocris Compounds for MMP11 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Drugbank Compounds for MMP11 Gene

(12) Novoseek inferred chemical compound relationships for MMP11 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 24.8 7
12-o-tetradecanoylphorbol 13-acetate 24.2 3
paraffin 22.7 4
progesterone 13.5 2
oxygen 1.95 1
genes like me logo Genes that share compounds with MMP11: view

Transcripts for MMP11 Gene

mRNA/cDNA for MMP11 Gene

Unigene Clusters for MMP11 Gene

Matrix metallopeptidase 11 (stromelysin 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for MMP11 Gene

GeneLoc Exon Structure for
MMP11
ECgene alternative splicing isoforms for
MMP11

Expression for MMP11 Gene

mRNA expression in normal human tissues for MMP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP11 Gene

This gene is overexpressed in Uterus (8.9), Cervix - Endocervix (6.1), and Cervix - Ectocervix (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP11 Gene

SOURCE GeneReport for Unigene cluster for MMP11 Gene Hs.143751

mRNA Expression by UniProt/SwissProt for MMP11 Gene

P24347-MMP11_HUMAN
Tissue specificity: Specifically expressed in stromal cells of breast carcinomas
genes like me logo Genes that share expressions with MMP11: view

Orthologs for MMP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP11 36
  • 99.04 (n)
  • 99.34 (a)
MMP11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP11 36
  • 85.22 (n)
  • 85.81 (a)
MMP11 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP11 36
  • 86.39 (n)
  • 88.74 (a)
MMP11 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp11 36
  • 83.01 (n)
  • 84.03 (a)
Mmp11 16
Mmp11 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP11 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp11 36
  • 82.82 (n)
  • 83.99 (a)
chicken
(Gallus gallus)
Aves LOC101751203 36
  • 68.42 (n)
  • 67.76 (a)
MMP11 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64247 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp11 36
  • 64.9 (n)
  • 68.6 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp11a 36
  • 62.04 (n)
  • 60.88 (a)
mmp11a 37
  • 54 (a)
OneToMany
mmp11b 37
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 22 (a)
OneToMany
Mmp2 38
  • 39 (a)
Mmp1 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
ManyToMany
Species with no ortholog for MMP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP11 Gene

ENSEMBL:
Gene Tree for MMP11 (if available)
TreeFam:
Gene Tree for MMP11 (if available)

Paralogs for MMP11 Gene

genes like me logo Genes that share paralogs with MMP11: view

Variants for MMP11 Gene

Sequence variations from dbSNP and Humsavar for MMP11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131449 -- 23,771,048(+) AAAAA(A/G)AAAAA upstream-variant-2KB
rs131450 -- 23,771,034(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs131451 -- 23,771,357(+) AACCC(C/T)GAAAA upstream-variant-2KB
rs738789 -- 23,774,399(+) AGCAT(G/T)TGGGG intron-variant
rs738790 -- 23,774,630(+) CTGTG(C/T)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP11 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914597 CNV Loss 21882294

Relevant External Links for MMP11 Gene

HapMap Linkage Disequilibrium report
MMP11

Disorders for MMP11 Gene

(3) University of Copenhagen DISEASES for MMP11 Gene

(45) Novoseek inferred disease relationships for MMP11 Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 64.3 37
carcinoma 59.2 77
dermatofibroma 57.2 9
metastasis 55.4 31
tumors 52.9 118

Relevant External Links for MMP11

Genetic Association Database (GAD)
MMP11
Human Genome Epidemiology (HuGE) Navigator
MMP11
genes like me logo Genes that share disorders with MMP11: view

No data available for UniProtKB/Swiss-Prot for MMP11 Gene

Publications for MMP11 Gene

  1. Structure and promoter characterization of the human stromelysin-3 gene. (PMID: 7657606) Anglard P. … Basset P. (J. Biol. Chem. 1995) 2 3 4 23
  2. Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PMID: 1639418) Levy A. … Basset P. (Genomics 1992) 2 3 23
  3. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PMID: 7746327) Pei D. … Weiss S.J. (Nature 1995) 3 4 23
  4. Stromelysin-3 is expressed by aggressive meningiomas. (PMID: 11857311) Perret A.G. … Mosnier J.F. (Cancer 2002) 3 23
  5. The expression of matrix metalloproteinase-11 protein in various types of glomerulonephritis. (PMID: 17085465) Nakopoulou L. … Stathakis C. (Nephrol. Dial. Transplant. 2007) 3 23

Products for MMP11 Gene

Sources for MMP11 Gene

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