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MMP10 Gene

protein-coding   GIFtS: 72
GCID: GC11M102641

Matrix Metallopeptidase 10 (Stromelysin 2)

(Previous name: matrix metalloproteinase 10 (stromelysin 2))
(Previous symbol: STMY2)
  See MMP10-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Matrix Metallopeptidase 10 (Stromelysin 2)1 2     Stromelysin 22
STMY21 2 3 5     stromelysin-22
Matrix Metalloproteinase 10 (Stromelysin 2)1 2     Transin 22
Matrix Metalloproteinase-102 3     transin-22
MMP-102 3     EC
SL-22 3     Transin-23
Matrix Metalloprotease 102     EC 3.4.248

External Ids:    HGNC: 71561   Entrez Gene: 43192   Ensembl: ENSG000001666707   OMIM: 1852605   UniProtKB: P092383   

Export aliases for MMP10 gene to outside databases

Previous GC identifiers: GC11M104834 GC11M103998 GC11M102675 GC11M102178 GC11M102146 GC11M098569

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP10 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and
fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MMP10 Gene:
MMP10 (matrix metallopeptidase 10 (stromelysin 2)) is a protein-coding gene. Diseases associated with MMP10 include mast cell neoplasm, and epidermolysis bullosa dystrophica. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238
Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates

summary for MMP10 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP10 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP10 gene promoter:
         CREB   SRF   AP-1   deltaCREB   ATF-2   SRF (504 AA)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP10 promoter sequence
   Search Chromatin IP Primers for MMP10

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22.3

MMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102641:  view genomic region     (about GC identifiers)

102,641,233 bp from pter      End:
102,651,359 bp from pter
10,127 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 (See protein sequence)
Recommended Name: Stromelysin-2 precursor  
Size: 476 amino acids; 54151 Da
Cofactor: Binds 2 zinc ions per subunit
Cofactor: Calcium
3 PDB 3D structures from and Proteopedia for MMP10:
1Q3A (3D)        3V96 (3D)        4ILW (3D)    
Secondary accessions: B2R9X9 Q53HH9

Explore the universe of human proteins at neXtProt for MMP10: NX_P09238

Explore proteomics data for MMP10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP10 (P09238) (see all 12)

    See MMP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002416.1  
    ENSEMBL proteins: 
     ENSP00000279441   ENSP00000441485  
    Reactome Protein details: P09238

    MMP10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP10 (MMP-10)
    Enzo Life Sciences proteins for MMP10
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MMP10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MMP10
    GenScript Custom Purified and Recombinant Proteins Services for MMP10
    Novus Biologicals MMP10 Proteins
    Novus Biologicals MMP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP10

    Search eBioscience for Proteins for MMP10 

    antibodies-online proteins for MMP10 (17 products) 

    antibodies-online peptides for MMP10

    GeneTex Proteins for MMP10:  
                        MMP-9 recombinant protein (GTX65181)

    MMP10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP10
    R&D Systems Antibodies for MMP10 (MMP-10)
    OriGene Antibodies for MMP10
    OriGene Custom Antibody Services for MMP10
    Novus Biologicals MMP10 Antibodies
    Abcam antibodies for MMP10
    Cloud-Clone Corp. Antibodies for MMP10
    ThermoFisher Antibody for MMP10
    antibodies-online antibodies for MMP10 (97 products) 

    GeneTex Antibodies for MMP10:  
                        MMP10 Antibodies

    MMP10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP10
    R&D Systems ELISAs for MMP10 (MMP-10)         (see all)
    GenScript MMP10-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP10
    Cloud-Clone Corp. ELISAs for MMP10
    Cloud-Clone Corp. CLIAs for MMP10
    Search eBioscience for ELISAs for MMP10 
    antibodies-online kits for MMP10 (51 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP10
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P09238

    ProtoNet protein and cluster: P09238

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1

    UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats

    Find genes that share domains with MMP10           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP10_HUMAN, P09238
    Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates
    Catalytic activity: Similar to stromelysin 1, but action on collagen types III, IV and V is weak

         Genatlas biochemistry entry for MMP10:
    matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone

         Enzyme Numbers (IUBMB): EC 3.4.242 EC

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
    Find genes that share ontologies with MMP10           About GenesLikeMe

         1 GenomeRNAi human phenotype for MMP10:
     Proliferating cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp10):
     cardiovascular system  immune system  normal  respiratory system 

    Find genes that share phenotypes with MMP10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MMP10: Mmp10tm1Jkmg Mmp10tm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for MMP10

        Taconic Biosciences Mouse Models for MMP10:  
                        TF0938 - Mmp10

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for MMP10

    miRTarBase miRNAs that target MMP10:
    hsa-mir-26b-5p (MIRT028865)

    Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP10:
    SwitchGear 3'UTR luciferase reporter plasmidMMP10 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for MMP10
    Predesigned siRNA for gene silencing in human, mouse, rat MMP10

    OriGene clones in human, mouse for MMP10 (see all 6)
    OriGene ORF clones in mouse, rat for MMP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
    Sino Biological Human cDNA Clone for MMP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

    Cell Line
    GenScript Custom overexpressing Cell Line Services for MMP10
    ESI BIO PureStem Progenitor for MMP10: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    MMP10_HUMAN, P09238: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    endoplasmic reticulum2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS2844164
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MMP10           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for MMP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    3Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    5Cell adhesion_ECM remodeling
    Cell adhesion_ECM remodeling

    Find genes that share SuperPaths with MMP10           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP10
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 GeneGo (Thomson Reuters) Pathway for MMP10
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP10
        Matrix Metalloproteinases

    3 Reactome Pathways for MMP10
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP10: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tumor Metastasis in human mouse rat


        GeneGlobe Interaction Network for MMP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MMP10 (P092383 ENSP000002794414) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAPLN1P109153, ENSP000002743414I2D: score=1 STRING: ENSP00000274341
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    BCANQ96GW73, ENSP000003312104I2D: score=2 STRING: ENSP00000331210
    MMP1ENSP000003227884STRING: ENSP00000322788
    MMP2ENSP000002190704STRING: ENSP00000219070
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS2844164
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030334regulation of cell migration IEA--
    GO:0030574collagen catabolic process TAS--

    Find genes that share ontologies with MMP10           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP10
      Browse compounds at ApexBio 

    Compounds for MMP10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for MMP10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetantagonist10852638 10669951

    7 Novoseek inferred chemical compound relationships for MMP10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 74.2 1 9578462 (1)
    matrigel 22.8 1 12379519 (1)
    12-o-tetradecanoylphorbol 13-acetate 9.97 1 8144618 (1)
    serine 8.4 6 15870107 (3), 19762781 (1), 16983356 (1), 17069010 (1)
    vegf 4.55 3 15868281 (1), 16980307 (1), 19220217 (1)
    oligonucleotide 0 2 8269280 (1), 9550265 (1)
    calcium 0 2 19769250 (1)

    Find genes that share compounds with MMP10           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for MMP10 gene: 

    Unigene Cluster for MMP10:

    Matrix metallopeptidase 10 (stromelysin 2)
    Hs.2258  [show with all ESTs]
    Unigene Representative Sequence: NM_002425
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279441(uc001phg.2) ENST00000539681
    Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP10:
    SwitchGear 3'UTR luciferase reporter plasmidMMP10 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for MMP10
    Predesigned siRNA for gene silencing in human, mouse, rat MMP10
    OriGene clones in human, mouse for MMP10 (see all 6)
    OriGene ORF clones in mouse, rat for MMP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10
    OriGene qPCR primer pairs and template standards for MMP10
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP10
      QuantiTect SYBR Green Assays in human, mouse, rat MMP10
      QuantiFast Probe-based Assays in human, mouse, rat MMP10

    Additional mRNA sequence: 

    AK222601.1 AK313960.1 BC002591.2 BT007442.1 X07820.1 

    5 DOTS entries:

    DT.106379  DT.120702938  DT.120702949  DT.99929471  DT.313463 

    Selected AceView cDNA sequences (see all 56):

    BP350564 BP350592 BP352531 AW949366 BP351427 BT007442 BP351309 BE740153 
    BP351724 BP351322 BP352568 BX281044 AI973162 BC002591 NM_002425 X07820 
    BP351604 BP352259 CF596568 CB528312 BP351299 BF034537 BM480245 BP351055 

    GeneLoc Exon Structure

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MMP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MMP10 Expression
    About this image

    MMP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    MMP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP10: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tumor Metastasis in human mouse rat

    OriGene qPCR primer pairs and template standards for MMP10
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP10
    QuantiTect SYBR Green Assays in human, mouse, rat MMP10
    QuantiFast Probe-based Assays in human, mouse, rat MMP10
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MMP10 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Mmp101 , 5 matrix metallopeptidase 101, 5 80.35(n)1
      9 (2.46 cM)5
    173841  NM_019471.21  NP_062344.11 
    (Gallus gallus)
    Aves MMP101 matrix metallopeptidase 10 (stromelysin 2) 62.74(n)
      418981  NM_001278089.1  NP_001265018.1 
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    many ↔ many
    many ↔ many

    ENSEMBL Gene Tree for MMP10 (if available)
    TreeFam Gene Tree for MMP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for MMP10 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP272  MMP112  MMP172  MMP12  
    18 SIMAP similar genes for MMP10 using alignment to 2 protein entries:     MMP10_HUMAN (see all proteins):
    MMP3    MMP1    MMP13    MMP12    MMP27    MMP8
    MMP20    MMP7    MMP2    MMP26    MMP17    MMP14
    MMP11    MMP16    MMP19    MMP24    MMP25    MMP15

    Find genes that share paralogs with MMP10           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for MMP10 (see all 386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 11 posSequence#AA
    A breast cancer sample4--see VAR_0361392 E Q mis40--------
    --102640800(+) TGAGGC/GGGAGA 1 -- ds50010--------
    C,F,A,H--102640805(+) GGGAGA/CTGAGA 1 -- ds500119Minor allele frequency- C:0.44NS EA NA WA 1416
    C,F--102640838(-) GTGGGA/TTTCCT 1 -- ds50018Minor allele frequency- T:0.12NS NA CSA 312
    --102640882(+) TGGACA/TCCAAA 1 -- ds50010--------
    C--102640935(+) ATAATA/GTGCAG 1 -- ds50010--------
    C--102640969(-) GAAATG/TGAACT 1 -- ds50011Minor allele frequency- T:0.01NS 180
    --102641024(+) TTACCC/TCTTTC 1 -- ds50010--------
    F--102641042(+) GGTGTG/ATAAGG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    --102641061(+) CAATAA/TCTGTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MMP10 (102641233 - 102651359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv463CNV Insertion18451855

    Human Gene Mutation Database (HGMD): MMP10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 185260    OMIM disorders: --

    10 diseases for MMP10:    
    About MalaCards
    mast cell neoplasm    epidermolysis bullosa dystrophica    keratoconus    arthritis
    refractive error    merkel cell carcinoma    transitional cell carcinoma    vernal keratoconjunctivitis
    bladder transitional cell carcinoma    richter's syndrome

    2 inferred disease relationships from the University of Copenhagen DISEASES database for MMP10:
    Lymphoma     Mast cell neoplasm

    Find genes that share disorders with MMP10           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MMP10 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    invasive cancer 48.3 1 19601983 (1)
    squamous cell cancer 47.3 2 19601983 (1)
    hnscc 43.4 1 16265652 (1)
    carcinoma squamous cell 42.6 7 12269770 (2), 17587817 (1), 14977049 (1), 11237387 (1)
    tumors 38.3 61 15833553 (5), 17695449 (4), 15720804 (3), 15356104 (2) (see all 20)
    metastasis 37 5 11487270 (1), 15557792 (1), 19921252 (1), 17695449 (1) (see all 5)
    keratoconus 37 1 11778801 (1)
    venous ulcer 34.3 3 11069614 (2), 8776359 (1)
    skin cancer 25.5 3 19601983 (1), 11237387 (1)
    carcinoma 24.1 7 1655673 (2), 7677979 (1), 1793490 (1), 11237387 (1)

    Genetic Association Database (GAD): MMP10
    Human Genome Epidemiology (HuGE) Navigator: MMP10 (12 documents)

    Export disorders for MMP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MMP10 gene, integrated from 10 sources (see all 206) (see top 10):
    (articles sorted by number of sources associating them with MMP10)

    1. Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PubMed id 15095982)1, 2, 9 Bertini I....Terni B. (J. Mol. Biol. 2004)
    2. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)1, 4, 9 Ogata T....Kuivaniemi H. (J. Vasc. Surg. 2005)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    6. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. (PubMed id 18035073)1, 4 Hlatky M.A....Go A.S. (Am. Heart J. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The collagenase gene family in humans consists of at least four members. (PubMed id 2844164)1, 2 Muller D....Breathnach R. (Biochem. J. 1988)
    11. Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. (PubMed id 17009259)1, 9 Barksby H.E....Rowan A.D. (Arthritis Rheum. 2006)
    12. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. (PubMed id 19695094)1, 9 Richardson S.M....Hoyland J.A. (amp 2009)
    13. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. (PubMed id 18427549)1, 9 Frederick L.A....Fields A.P. (Oncogene 2008)
    14. Expression of MMP-10 in lung cancer. (PubMed id 17695449)1, 9 Zhang X....Xu N. (Anticancer Res. 2007)
    15. Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. (PubMed id 8349617)1, 9 Windsor L.J....Birkedal-Hansen H. (J. Biol. Chem. 1993)
    16. Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation. (PubMed id 19762781)1, 9 Orbe J....PA!ramo J.A. (Arterioscler. Thromb. Vasc. Biol. 2009)
    17. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. (PubMed id 16331256)1, 9 Aung P.P....Yasui W. (Oncogene 2006)
    18. Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases. (PubMed id 9578462)1, 9 Nakamura H....Okada Y. (Eur. J. Biochem. 1998)
    19. MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. (PubMed id 19601983)1, 9 Boyd S....Saarialho-Kere U. (Exp. Dermatol. 2009)
    20. Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs. (PubMed id 19935709)1, 9 Ishikawa F....Shibanuma M. (Oncogene 2010)
    21. Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma. (PubMed id 19921252)1, 9 Suomela S....Saarialho-Kere U. (Virchows Arch. 2009)
    22. Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development. (PubMed id 9662124)1, 9 Bord S....Compston J.E. (Bone 1998)
    23. Activation of human neutrophil procollagenase by stromelysin 2. (PubMed id 8631328)1, 9 KnAouper V....Tschesche H. (Eur. J. Biochem. 1996)
    24. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study. (PubMed id 19317417)1, 9 Cuadrado E....Montaner J. (J. Proteome Res. 2009)
    25. C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis. (PubMed id 16580524)1, 9 Montero I....PA!ramo J.A. (J. Am. Coll. Cardiol. 2006)
    26. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PubMed id 16054593)1, 9 Schnabl B....SchAPlmerich J. (Biochem. Biophys. Res. Commun. 2005)
    27. cDNA cloning and expression of the gene encoding murine stromelysin-2 (MMP-10). (PubMed id 9427548)1, 9 Madlener M. and Werner S. (Gene 1997)
    28. Expression pattern of matrix metalloproteinases in human liver. (PubMed id 7632822)1, 9 Lichtinghagen R....BAPker K.H. (Eur J Clin Chem Clin Biochem 1995)
    29. Beta-carotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism. (PubMed id 15288123)1, 9 Wertz K....Goralczyk R. (amp 2004)
    30. Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. (PubMed id 8144618)1, 9 Gack S....Angel P. (J. Biol. Chem. 1994)
    31. Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes. (PubMed id 10472874)1, 9 Fortunato S.J....Lombardi S.J. (Obstet Gynecol 1999)
    32. Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. (PubMed id 7694569)1, 9 Nguyen Q....Roughley P.J. (Biochem. J. 1993)
    33. Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. (PubMed id 1874716)1, 9 Fosang A.J....Hamilton J.A. (J. Biol. Chem. 1991)
    34. Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization. (PubMed id 2369069)1, 9 Jung J.Y....Rumpler Y. (Ann. Genet. 1990)
    35. The role of DNA hypomethylation in the control of stromelysin gene expression. (PubMed id 16516860)1, 9 Couillard J....St-Pierre Y. (Biochem. Biophys. Res. Commun. 2006)
    36. [Association between matrix metalloproteinase-10 gene polymorphisms and instability of carotid plaque]. (PubMed id 24327153)1 Zhu F....Zheng Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2013)
    37. proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke. (PubMed id 23742289)1 RodrA-guez J.A....PA!ramo J.A. (J. Thromb. Haemost. 2013)
    38. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PubMed id 23412934)1 Gourraud P.A....Baranzini S.E. (Brain 2013)
    39. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    40. C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma. (PubMed id 22821423)1 Sze K.M....Ng I.O. (Hepatology 2013)
    41. Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. (PubMed id 24255036)1 Saghizadeh M....Ljubimov A.V. (amp 2013)
    42. Matrix metalloproteinases and educational attainment in refractive error: evidence of gene-environment interactions in the Age-Related Eye Disease Study. (PubMed id 23098370)1 Wojciechowski R....Stambolian D. (Ophthalmology 2013)
    43. Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion. (PubMed id 22524815)1 Cheng D....Li Y.H. (Asian Pac. J. Cancer Prev. 2012)
    44. Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma. (PubMed id 22121946)1 Liu H....Guan X.Y. (Dis. Esophagus 2012)
    45. Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo. (PubMed id 22492089)1 MartA-nez de Lizarrondo S....Orbe J. (Arterioscler. Thromb. Vasc. Biol. 2012)
    46. Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. (PubMed id 22545096)1 Justilien V....Fields A.P. (PLoS ONE 2012)
    47. Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. (PubMed id 22427646)1 Batra J....Radisky E.S. (J. Biol. Chem. 2012)
    48. Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis. (PubMed id 21925226)1 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2011)
    49. Type-specific dysregulation of matrix metalloproteinases and their tissue inhibitors in end-stage heart failure patients: relationship between MMP-10 and LV remodelling. (PubMed id 20219015)1 Wei Y....Hu S. (J. Cell. Mol. Med. 2011)
    50. Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 level. (PubMed id 20215736)1 Komosinska-Vassev K....Olczyk K. (Gerontology 2011)
    51. Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. (PubMed id 22022614)1 Regala R.P....Fields A.P. (PLoS ONE 2011)
    52. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. (PubMed id 21121903)4 Rasi S....Rossi D. (Br. J. Haematol. 2011)
    53. MMP-10/stromelysin-2 promotes invasion of head and neck cancer. (PubMed id 21998657)1 Deraz E.M....Takata T. (PLoS ONE 2011)
    54. Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism. (PubMed id 22104553)1 Orbe J....PA!ramo J.A. (Circulation 2011)
    55. Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells. (PubMed id 20936527)1 Mauro A....Gerbino A. (J. Mol. Histol. 2010)
    56. Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma. (PubMed id 20584750)1 Clemons N.J....Fitzgerald R.C. (Carcinogenesis 2010)
    57. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. (PubMed id 20484597)1 Wojciechowski R....Stambolian D. (amp 2010)
    58. Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis. (PubMed id 20432469)1 Heo S.H....Cho J.Y. (J. Cell. Physiol. 2010)
    59. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    60. Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. (PubMed id 19489686)1 Yen C.Y....Chang H.W. (Biomarkers 2009)
    61. VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. (PubMed id 18617643)1 Ha C.H....Jin Z.G. (Arterioscler. Thromb. Vasc. Biol. 2008)
    62. Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. (PubMed id 17543340)1 Asano T....Kondo S. (J. Surg. Res. 2008)
    63. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    64. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    65. Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. (PubMed id 15371548)1 Krampert M....Werner S. (Mol. Biol. Cell 2004)
    66. Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer. (PubMed id 15375490)1 Lin T.S....Chow K.C. (Oncol. Rep. 2004)
    67. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    68. Clinical potential of matrix metalloprotease inhibitors in cancer therapy. (PubMed id 10852638)7 Heath E.I. and Grochow L.B. (Drugs 2000)
    69. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. (PubMed id 10986281)1 Nakamura H....Okada Y. (J. Biol. Chem. 2000)
    70. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    71. Matrix metalloproteinases. (PubMed id 10419448)1 Nagase H. and Woessner J.F. (J. Biol. Chem. 1999)
    72. MMP inhibitors: experimental and clinical studies. (PubMed id 10669951)7 Belotti D....Giavazzi R. (Int. J. Biol. Markers 1999)
    73. Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview. (PubMed id 9042108)1 Chandler S....Gearing A.J. (J. Neuroimmunol. 1997)
    74. Activation of type IV procollagenases by human tumor-associated trypsin-2. (PubMed id 9261109)1 Sorsa T....Stenman U.H. (J. Biol. Chem. 1997)
    75. Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. (PubMed id 8921407)1 PendA!s A.M....LA^pez-OtA-n C. (Genomics 1996)
    76. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    77. Human T lymphocytes express a member of the Matrix Metalloproteinase gene family. (PubMed id 8003069)1 Conca W. and Willmroth F. (Arthritis Rheum. 1994)
    78. Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. (PubMed id 2605216)1 Sirum K.L. and Brinckerhoff C.E. (Biochemistry 1989)
    79. IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line. (PubMed id 20032397)9 Zhang X....Xu N. (Anticancer Res. 2009)
    80. Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma. (PubMed id 15833553)9 Seargent J.M....Gill J.H. (Urology 2005)
    81. Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. (PubMed id 15356104)9 Van Themsche C....St-Pierre Y. (J. Immunol. 2004)
    82. MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas. (PubMed id 15720804)9 Gill J.H....Loadman P.M. (Neoplasia 2004)
    83. Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli. (PubMed id 17981764)9 Rodriguez J.A....Paramo J.A. (Front. Biosci. 2008)
    84. Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. (PubMed id 17059420)9 Orbe J....PA!ramo J.A. (J. Thromb. Haemost. 2007)
    85. Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role. (PubMed id 17207914)9 Miyata Y....Kanetake H. (Eur. Urol. 2007)
    86. Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. (PubMed id 15545168)9 Salmela M.T....Saarialho-Kere U. (Scand. J. Gastroenterol. 2004)
    87. Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. (PubMed id 11237387)9 KerkelAo E....Saarialho-Kere U. (Br. J. Cancer 2001)
    88. Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. (PubMed id 8463259)9 Sanchez-Lopez R....Werb Z. (J. Biol. Chem. 1993)
    89. Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells. (PubMed id 18552508)9 Zhao Y....Heng C.K. (J. Vasc. Res. 2009)
    90. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines. (PubMed id 11069614)9 Rechardt O....Saarialho-Kere U. (J. Invest. Dermatol. 2000)
    91. [The effect of Nifedipine and mechanical strain on matrix metalloproteinase expression in human periodontal ligament fibroblast]. (PubMed id 19769250)9 Ni H....Sun M. (Hua Xi Kou Qiang Yi Xue Za Zhi 2009)
    92. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. (PubMed id 19799791)9 Lorente L....PA!ramo J.A. (Crit Care 2009)
    93. Expression of stromelysin and stromelysin-2 in rabbit and human fibroblasts. (PubMed id 1480018)9 Brinckerhoff C.E....Auble D.T. (Matrix Suppl 1992)
    94. Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. (PubMed id 19828126)9 Saghizadeh M....Ljubimov A.V. (Brain Res. Bull. 2010)
    95. Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expression. (PubMed id 19682763)9 Tomomatsu T....Akagi Y. (Diabetes Res. Clin. Pract. 2009)
    96. Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (PubMed id 16670920)9 Dannewitz B....Steinberg T. (Cell Tissue Res. 2006)
    97. Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells. (PubMed id 17054435)9 Hasebe Y....Nose K. (Cancer Sci. 2007)
    98. Disturbances of the expression of metalloproteinases and their tissue inhibitors cause destruction of the basement membrane in pemphigoid. (PubMed id 17019968)9 Narbutt J....Zebrowska A. (Pol J Pathol 2006)
    99. MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. (PubMed id 15870107)9 Saunders W.B....Davis G.E. (J. Cell. Sci. 2005)
    100. MMP expression profiling in recurred stage IB lung cancer. (PubMed id 14647437)9 Cho N.H....Cho S.H. (Oncogene 2004)
    101. Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. (PubMed id 14977049)9 Ramos M.C....Brenneisen P. (Biol. Chem. 2004)
    102. Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas. (PubMed id 14666700)9 Thorns V....Thorns C. (Anticancer Res. 2003)
    103. Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. (PubMed id 12873452)9 Kabosova A....Ljubimov A.V. (Exp. Eye Res. 2003)
    104. Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia. (PubMed id 1353052)9 Colombi M....Barlati S. (Hum. Genet. 1992)
    105. Regulation of extracellular matrix remodeling following transforming growth factor-beta1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes. (PubMed id 17587817)9 Wilkins-Port C.E. and Higgins P.J. (Cells Tissues Organs (Print) 2007)
    106. Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications. (PubMed id 12269770)9 Mathew R....Ralhan R. (Cancer Detect. Prev. 2002)
    107. Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. (PubMed id 12379519)9 Tolboom T.C....Huizinga T.W. (Ann. Rheum. Dis. 2002)
    108. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. (PubMed id 11159210)9 Saghizadeh M....Ljubimov A.V. (Am. J. Pathol. 2001)
    109. 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection. (PubMed id 19178594)9 Coussens A....Martineau A.R. (Immunology 2009)
    110. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. (PubMed id 19886850)9 Friese R.S....O'Connor D.T. (Clin. Exp. Hypertens. 2009)
    111. Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. (PubMed id 19220217)9 Leonardi A....Sack R. (Allergy 2009)
    112. Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. (PubMed id 18463162)9 Gao C....Kao H.Y. (Mol. Biol. Cell 2008)
    113. Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum. (PubMed id 18001410)9 Bister V....Saarialho-Kere U. (J. Cutan. Pathol. 2007)
    114. Expression of matrix metalloproteinases 3, 10 and 11 (stromelysins 1, 2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms. Clinicopathologic studies. (PubMed id 16506596)9 Kren L....Ross J.S. (Cesk Patol 2006)
    115. Molecular balance of capillary tube formation versus regression in wound repair: role of matrix metalloproteinases and their inhibitors. (PubMed id 17069010)9 Davis G.E. and Saunders W.B. (J. Investig. Dermatol. Symp. Proc. 2006)
    116. Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers. (PubMed id 9710383)9 Saarialho-Kere U.K. (Arch. Dermatol. Res. 1998)
    117. Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds. (PubMed id 8040294)9 Saarialho-Kere U.K....Welgus H.G. (J. Clin. Invest. 1994)
    118. The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23. (PubMed id 8486377)9 Formstone C.J....Taylor A.M. (Genomics 1993)
    119. Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization. (PubMed id 1655673)9 Polette M....Birembaut P. (amp 1991)
    120. (PubMed id 16983356)9 
    121. A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis. (PubMed id 19804592)9 Harper J.I....Chandler S. (Br. J. Dermatol. 2010)
    122. Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion. (PubMed id 19695317)9 Fujita K....Nakanishi J. (Toxicol. Lett. 2009)
    123. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. (PubMed id 19664131)9 Lee J....Park C.K. (APMIS 2009)
    124. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. (PubMed id 19610059)9 Singh S....Lillard J.W. (Int. J. Cancer 2009)
    125. Polyclonal immunoglobulins (IVIg) induce expression of MMP-9 in microglia. (PubMed id 19833395)9 Pul R....Stangel M. (J. Neuroimmunol. 2009)
    126. CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells. (PubMed id 19723873)9 Armstrong D.A....Vincenti M.P. (Mol. Cancer Res. 2009)
    127. Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease after immunosuppressive treatment correlate with histological score and calprotectin values. (PubMed id 19652986)9 MAokitalo L....Saarialho-Kere U. (Int J Colorectal Dis 2009)
    128. Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans. (PubMed id 19961380)9 Offenbacher S....Ho B. (J. Periodontol. 2009)
    129. Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. (PubMed id 19243594)9 Eiseler T....Storz P. (Breast Cancer Res. 2009)
    130. Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis? (PubMed id 20017890)9 Hoffmann U....Borggrefe M. (Crit Care 2009)
    131. Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease. (PubMed id 19080965)9 PA!ramo J.A....Orbe J. (Rev Esp Cardiol 2008)
    132. Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. (PubMed id 18162290)9 Li L.B....Zou J.X. (Cancer Lett. 2008)
    133. Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus. (PubMed id 18520507)9 Maguen E....Ljubimov A.V. (Cornea 2008)
    134. Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. (PubMed id 18391785)9 Davis G.E. and Senger D.R. (Curr. Opin. Hematol. 2008)
    135. Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. (PubMed id 18268205)9 FourniAc P.R....Fini M.E. (Arch. Ophthalmol. 2008)
    136. Co-activation of synovial fibroblasts by laminin-111 and transforming growth factor-beta induces expression of matrix metalloproteinases 3 and 10 independently of nuclear factor-kappaB. (PubMed id 17720720)9 Warstat K....Aicher W.K. (Ann. Rheum. Dis. 2008)
    137. Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls. (PubMed id 18034264)9 Boyd S....Saarialho-Kere U. (Virchows Arch. 2008)
    138. Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. (PubMed id 18442906)9 Subramaniam R....Mallik S. (amp 2008)
    139. The carbon monoxide-releasing molecule tricarbonyldichlororuthenium(II) dimer protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1beta. (PubMed id 18195133)9 MegA-as J....Alcaraz M.J. (J. Pharmacol. Exp. Ther. 2008)
    140. No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. (PubMed id 18768525)9 Qiu W....He F. (amp 2008)
    141. The role of stratifin in fibroblast-keratinocyte interaction. (PubMed id 17646930)9 Medina A....Ghahary A. (Mol. Cell. Biochem. 2007)
    142. mRNA profiling for body fluid identification by multiplex quantitative RT-PCR. (PubMed id 17868268)9 Juusola J. and Ballantyne J. (J. Forensic Sci. 2007)
    143. Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)9 Vendelin J....Kere J. (Hum. Mol. Genet. 2006)
    144. A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. (PubMed id 16980307)9 Abid M.R....Aird W.C. (J. Biol. Chem. 2006)
    145. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. (PubMed id 16205632)9 Itoh M....Yoshida K. (Oncogene 2006)
    146. Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas. (PubMed id 16265652)9 GAPrAPgh T....Maune S. (amp 2006)
    147. Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections. (PubMed id 17129374)9 Kanangat S....Schaberg D. (amp 2006)
    148. Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas. (PubMed id 16699496)9 Kuivanen T.T....Saarialho-Kere U.K. (Mod. Pathol. 2006)
    149. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. (PubMed id 16677108)9 Roy S....Sen C.K. (amp 2006)
    150. Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis. (PubMed id 15899818)9 Meyer E....Stamenkovic I. (Cancer Res. 2005)
    151. Response of matrix metalloproteinases and tissue inhibitors of metalloproteinases messenger ribonucleic acids to ovarian steroids in human endometrial explants mimics their gene- and phase-specific differential control in vivo. (PubMed id 16046583)9 Vassilev V....Henriet P. (J. Clin. Endocrinol. Metab. 2005)
    152. Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. (PubMed id 15840104)9 Impola U....Saarialho-Kere U. (Br. J. Dermatol. 2005)
    153. Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells. (PubMed id 15944920)9 Krikun G....Lockwood C.J. (Histol. Histopathol. 2005)
    154. Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. (PubMed id 16316467)9 Ritter M....Seither P. (J Inflamm (Lond) 2005)
    155. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. (PubMed id 16186340)9 Saghizadeh M....Ljubimov A.V. (amp 2005)
    156. A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke. (PubMed id 15947272)9 Rosell A....Montaner J. ( a journal of cerebral circulation 2005)
    157. Localization of matrix metalloproteinases, (MMPs) their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation. (PubMed id 15868281)9 Haeusler G....Egerbacher M. (Calcif. Tissue Int. 2005)
    158. Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities. (PubMed id 15716237)9 Roebuck M.M....Frostick S.P. (Am. J. Clin. Pathol. 2005)
    159. Differential expression of matrix metalloproteinases in viral and non-viral chronic liver diseases. (PubMed id 15469875)9 Ljumovic D....Kouroumalis E.A. ( international journal of clinical chemistry 2004)
    160. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. (PubMed id 15623660)9 Singh S....Lillard J.W. (Clin. Cancer Res. 2004)
    161. Expression of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines. (PubMed id 15671765)9 Baldini E....D'Armiento M. (Thyroid 2004)
    162. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. (PubMed id 15262646)9 Lo I.K....Frank C.B. (Am J Sports Med 2004)
    163. Expression of matrix metalloproteinases in supraglottic carcinoma and its clinical implication for estimating lymph node metastases. (PubMed id 15564854)9 Xie M....Li Y. (Laryngoscope 2004)
    164. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. (PubMed id 15467730)9 Singh S....Lillard J.W. ( a journal of technical methods and pathology 2004)
    165. Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease. (PubMed id 15082589)9 Kirkegaard T....Brynskov J. (Gut 2004)
    166. Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue. (PubMed id 14609553)9 Daniels J.T....Saarialho-Kere U. (Exp. Eye Res. 2003)
    167. Effects of HDL3 on the expression of matrix-degrading proteases in human endothelial cells. (PubMed id 12792812)9 Norata G.D....Eriksson P. (Int. J. Mol. Med. 2003)
    168. Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. (PubMed id 12235077)9 Salmela M.T....Pender S.L. (Gut 2002)
    169. C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. (PubMed id 11755824)9 O-charoenrat P....Eccles S.A. (Oral Oncol. 2002)
    170. Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma. (PubMed id 11487270)9 Salmela M.T....Saarialho-Kere U. (Br. J. Cancer 2001)
    171. Is the corneal degradation in keratoconus caused by matrix-metalloproteinases? (PubMed id 11778801)9 Collier S.A. (amp 2001)
    172. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. (PubMed id 11448356)9 O-Charoenrat P....Eccles S.A. (amp 2001)
    173. Metalloelastase (MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors, TIMP-1 and -3, are expressed in psoriatic lesions. (PubMed id 11380613)9 Suomela S....Saarialho-Kere U. (Exp. Dermatol. 2001)
    174. Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (PubMed id 11247893)9 Salmela M.T....Saarialho-Kere U. (Gut 2001)
    175. Expression and activity of matrix metalloproteases in human malignant mesothelioma cell lines. (PubMed id 11267973)9 Liu Z....Klominek J. (Int. J. Cancer 2001)
    176. Analysis of matrix metalloproteinase mRNAs expressed in hepatocellular carcinoma cell lines. (PubMed id 11561728)9 Kim J.H....Lee S.T. (Mol. Cells 2001)
    177. Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts. (PubMed id 11040455)9 Moore B.A....Windsor L.J. (Biochim. Biophys. Acta 2000)
    178. MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. (PubMed id 11355270)9 Birkedal-Hansen B....Stetler-Stevenson W.G. (Oral Dis 2000)
    179. Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints. (PubMed id 11033543)9 Takei I....Konttinen Y.T. (J. Biomed. Mater. Res. 2000)
    180. Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion. (PubMed id 10760816)9 O-Charoenrat P....Eccles S. (Int. J. Cancer 2000)
    181. High collagenolytic activity in spontaneously highly metastatic variants derived from a human pancreatic cancer cell line (SUIT-2) in nude mice. (PubMed id 11688961)9 Kitamura N....Setoguchi T. (amp 2000)
    182. Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone. (PubMed id 10071915)9 Bord S....Compston J.E. (Bone 1999)
    183. Differential expression of matrix metalloproteinases in bacterial meningitis. (PubMed id 10430840)9 Kieseier B.C....Hartung H.P. (Brain 1999)
    184. Purification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors. (PubMed id 10336863)9 Kannan R....Basset P. (Protein Expr. Purif. 1999)
    185. Overview of matrix metalloproteinase expression in cultured human cells. (PubMed id 9550265)9 Giambernardi T.A....Klebe R.J. (Matrix Biol. 1998)
    186. Effect of glucose and heparin on mesangial alpha 1(IV)COLL and MMP-2/TIMP-2 mRNA expression. (PubMed id 9075122)9 Caenazzo C....Gambaro G. (Nephrol. Dial. Transplant. 1997)
    187. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. (PubMed id 8776359)9 Vaalamo M....Saarialho-Kere U.K. (Br. J. Dermatol. 1996)
    188. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. (PubMed id 8686751)9 Heppner K.J....Rodgers W.H. (Am. J. Pathol. 1996)
    189. mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in interface tissue around implants in loosening total hip arthroplasty. (PubMed id 8953151)9 Ishiguro N....Iwata H. (J. Biomed. Mater. Res. 1996)
    190. The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family. (PubMed id 7607691)9 PendA!s A.M....LA^pez-OtA-n C. (Genomics 1995)
    191. Neutrophil procollagenase can be activated by stromelysin-2. (PubMed id 7978810)9 KnAouper V....Tschesche H. (Ann. N. Y. Acad. Sci. 1994)
    192. Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC. (PubMed id 8370623)9 Alessandro R....Woolley D.E. (Int. J. Cancer 1993)
    193. Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. (PubMed id 7677979)9 Muller D....Methlin G. (Cancer Res. 1993)
    194. Isolation and characterization of a high molecular weight type IV collagenase isolated from human carcinoma tissue. (PubMed id 8384126)9 Tsuda T.T....Tsuda M. (FEBS Lett. 1993)
    195. Overproduction of metalloproteinases by v-mos-transformed rat kidney (6m2) cells. (PubMed id 1602817)9 Chan J.C. (Leukemia 1992)
    196. Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas. (PubMed id 1793490)9 McDonnell S....Matrisian L.M. (Mol. Carcinog. 1991)
    197. TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. (PubMed id 19383899)9 Wilkins-Port C.E....Higgins P.J. (Cancer Res. 2009)
    198. [Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients]. (PubMed id 18214499)9 Aicher W.K....Gay S. (Z Rheumatol 2008)

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    Entrez Gene: 4319 HGNC: 7156 AceView: MMP10 Ensembl:ENSG00000166670 euGenes: HUgn4319
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