MMP10 Gene
protein-coding GIFtS : 71
GCID: GC11 M102641
matrix metallopeptidase 10 (stromelysin 2) (Previous name: matrix metalloproteinase 10 (stromelysin 2) ) (Previous symbol: STMY2 )
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Aliasesfor MMP10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Matrix Metallopeptidase 10 (Stromelysin 2) 1 2 Stromelysin 22 STMY21 2 3 5 Stromelysin-21 Matrix Metalloproteinase 10 (Stromelysin 2)1 2 Transin 22 Matrix Metalloproteinase-102 3 Transin-23 MMP-102 3 EC 3.4.24.223 SL-22 3 Transin-23 Matrix Metalloprotease 102 EC 3.4.248
Export aliases for MMP10 gene to outside databases Previous GC identifers: GC11M104834 GC11M103998 GC11M102675 GC11M102178 GC11M102146 GC11M098569
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Summariesfor MMP10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MMP10 : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 Function : Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activatesprocollagenase summary
for MMP10 : Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependentendopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading awide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have beenidentified in humans, which can be organized into six groups based on domain organization and substratepreference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cellproliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPshas been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumorto secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of thebasement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselvesor by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMPexpression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 allhave elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs resultin inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion. Gene Wiki entry for MMP10
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Genomic Viewsfor MMP10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MMP10 gene promoter: CREB SRF AP-1 deltaCREB ATF-2 SRF (504 AA) c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for MMP10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3 MMP10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M102641: view genomic region
(about GC identifiers )
Start:
102,641,233 bp from pter
End:
102,651,359 bp from pter
Size:
10,127 bases
Orientation:
minus strand
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Proteinsfor MMP10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 (See
protein sequence )Recommended Name: Stromelysin-2 precursor Size : 476 amino acids; 54151 Da
Cofactor : Binds 2 zinc ions per subunit
Cofactor : Calcium
Subcellular location : Secreted, extracellular space, extracellular matrix (Probable)
2 PDB 3D structures from and Proteopedia for MMP10 :1Q3A (3D)
  3V96 (3D)
 
Secondary accessions : B2R9X9 Q53HH9Explore the universe of human proteins at neXtProt for MMP10: NX_P09238 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P09238 4/12 DME Specific Peptides for MMP10 (P09238 ) (see all 12 )MMP10 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002416.1 ENSEMBL proteins: ENSP00000279441 ENSP00000441485 Reactome Protein details: P09238 Human Recombinant Protein Products for MMP10: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
MMP10 for ontologies About GeneDecksing MMP10 Antibody Products: Assay Products for MMP10:
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Protein
Domains / Familiesfor MMP10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MMP10 for domains About GeneDecksing 5/10 InterPro domains/families (see all 10 ):
Graphical View of Domain Structure for InterPro Entry P09238 ProtoNet protein and cluster: P09238
3 Blocks protein families : IPB000585 Hemopexin repeat IPB001818 Matrixin IPB002477 Putative peptidoglycan binding domain 1 UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Similarity : Belongs to the peptidase M10A familySimilarity : Contains 4 hemopexin-like domains
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Functionfor MMP10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MMP10_HUMAN, P09238 Function : Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activatesprocollagenase Catalytic activity : Similar to stromelysin 1, but action on collagen types III, IV and V is weak
Genatlas biochemistry entry for MMP10 : matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone Enzyme Numbers (IUBMB): EC 3.4.24 2 EC 3.4.24.22 1 Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004222 metalloendopeptidase activity
IEA -- GO:0005509 calcium ion binding
IEA -- GO:0008270 zinc ion binding
IEA --
MMP10 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for MMP10 : 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mmp10) :
MMP10 for phenotypes About GeneDecksing Animal Models: Mouse knock-outs for MMP10: Mmp10 tm1Jkmg Mmp10 tm1Lex Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425 ) Sino Biological Human cDNA Clone for MMP10 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10
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Pathways & Interactionsfor MMP10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Degradation of the extracellular matrix 2 Cell adhesion_ECM remodeling 3 Matrix Metalloproteinases 4 Integrin Pathway 5 Activation of proMMP10
Pathway sources See GeneCards unified pathways Show all pathways 2 EMD Millipore Pathways for MMP10 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP10 1 GeneGo (Thomson Reuters) Pathway for MMP10 1 BioSystems Pathway for MMP10 5
Reactome Pathways for MMP10
MMP10 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MMP10 STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/8 Interacting proteins for MMP10 (P09238 3 ENSP00000279441 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006508 proteolysis
IEA -- GO:0022617 extracellular matrix disassembly
TAS -- GO:0030198 extracellular matrix organization
TAS -- GO:0030334 regulation of cell migration
IEA -- GO:0030574 collagen catabolic process
IEA --
MMP10 for ontologies About GeneDecksing
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Drugs & Compoundsfor MMP10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MMP10 for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for MMP10
Compounds for MMP10 available from Tocris Bioscience About this table Compound Action
CAS
# CP 471474 Broad spectrum MMP inhibitor [210755-45-6] Marimastat Broad spectrum MMP inhibitor [154039-60-8] ONO 4817 Broad spectrum MMP inhibitor [223472-31-9] Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4] PD 166793 Broad spectrum MMP inhibitor [199850-67-4]
1 HMDB Compound for MMP10 About this table 2 DrugBank Compounds for MMP10 About this table 7 Novoseek chemical compound relationships for MMP10 gene About this table
Search CenterWatch for drugs/clinical trials and news about MMP10
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Transcriptsfor MMP10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MMP10 gene: NM_002425.2 Unigene Cluster for MMP10:
Matrix metallopeptidase 10 (stromelysin 2) Hs.2258 [show with all ESTs ] Unigene Representative Sequence: NM_002425 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000279441 (uc001phg.2 ) ENST00000539681 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMP10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP10
Additional cDNA sequence: AK222601.1 AK313960.1 BC002591.2 BT007442.1 X07820.1
5 DOTS entries : DT.106379 DT.120702938
DT.120702949 DT.313463 DT.99929471 24/56 AceView cDNA sequences (see all 56 ):
BP350564 BP351427 BE740153 BT007442 BP351309 BC002591 BP351604 BP350592 BP352568 NM_002425 BP352531 AW949366 BX281044 BP351322 BP351724 X07820 AI973162 BP352259 CB528312 BP352575 CF596568 T27816 BP352805 BF034537 GeneLoc Exon Structure
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Expression for MMP10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MMP10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image MMP10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See MMP10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MMP10 SOURCE GeneReport for Unigene cluster: Hs.2258 SABiosciences Expression via Pathway-Focused PCR Arrays including MMP10 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMP10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MMP10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMP10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MMP10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10
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Orthologsfor MMP10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for MMP10 gene from 6/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for MMP10 (if available)TreeFam Gene Tree for MMP10 (if available)
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Paralogsfor MMP10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MMP10 gene MMP13 2 MMP20 2 MMP8 2 MMP14 2 MMP9 2 MMP16 2 MMP2 2 MMP25 2 MMP24 2 MMP15 2 MMP11 2 MMP3 2 MMP27 2 MMP17 2 MMP1 2 18 SIMAP similar genes for MMP10 using alignment to 2 protein entries: MMP10_HUMAN (see all proteins ):MMP3 MMP1 MMP13 MMP12 MMP27 MMP8 MMP20 MMP7 MMP2 MMP26 MMP17 MMP14 MMP11 MMP16 MMP19 MMP24 MMP25 MMP15
MMP10 for paralogs About GeneDecksing
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Genomic Variantsfor MMP10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MMP10 (102641233 - 102651359 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MMP10: -- Human Gene Mutation Database (HGMD) : MMP10 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMP10
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Disorders
/ Diseasesfor MMP10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MMP10 for disorders About GeneDecksing
OMIM gene information: 185260
OMIM disorders : --20/66 diseases for MMP10 (see all 66 ): About MalaCards epidermolysis bullosa dystrophica arthritis encephalomyelitis epidermolysis bullosa refractive error pyoderma gangrenosum abdominal aortic aneurysm mast cell neoplasm vernal keratoconjunctivitis aortic aneurysm bladder transitional cell carcinoma transitional cell carcinoma pyoderma squamous cell carcinoma gingival overgrowth myocardial infarction acute myocardial infarction squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma keratoconjunctivitis 2 diseases from the University of Copenhagen DISEASES database for MMP10 :Mast cell neoplasm Lymphoma 10/24 Novoseek disease relationships for MMP10 gene (see all 24 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
invasive cancer
48.3
1
19601983 (1)
squamous cell cancer
47.3
2
19601983 (1)
hnscc
43.4
1
16265652 (1)
carcinoma squamous cell
42.6
7
12269770 (2), 17587817 (1), 14977049 (1), 11237387 (1)
tumors
38.3
61
15833553 (5), 17695449 (4), 15720804 (3), 15356104 (2) (see all 20 )
metastasis
37
5
11487270 (1), 15557792 (1), 19921252 (1), 17695449 (1) (see all 5 )
keratoconus
37
1
11778801 (1)
venous ulcer
34.3
3
11069614 (2), 8776359 (1)
skin cancer
25.5
3
19601983 (1), 11237387 (1)
carcinoma
24.1
7
1655673 (2), 7677979 (1), 1793490 (1), 11237387 (1)
Genetic Association Database (GAD): MMP10 Human Genome Epidemiology (HuGE) Navigator: MMP10 (12 documents) Export disorders for MMP10 gene to outside databases
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Publicationsfor MMP10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MMP10 gene, integrated from 9 sources (see all 198 ) (see top 10 ): (articles sorted by number of sources associating them with MMP10) Utopia : connect your pdf to the dynamic world of online information
Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PubMed id 15095982) 1 , 2 , 9 Bertini I....Terni B. (2004) Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607) 1 , 4, 9 Ogata T....Kuivaniemi H. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The collagenase gene family in humans consists of at least four members. (PubMed id 2844164) 1 , 2 Muller D....Breathnach R. (1988) Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. (PubMed id 17009259) 1 , 9 Barksby H.E....Rowan A.D. (2006) Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral di sc. (PubMed id 19695094) 1 , 9 Richardson S.M....Hoyland J.A. (2009) Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. (PubMed id 18427549) 1 , 9 Frederick L.A....Fields A.P. (2008) Expression of MMP-10 in lung cancer. (PubMed id 17695449) 1 , 9 Zhang X....Xu N. (2007) Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. (PubMed id 8349617) 1 , 9 Windsor L.J....Birkedal-Hansen H. (1993) Matrix metalloproteinase-10 is upregulated by thrombi n in endothelial cells and increased in patients with enhanced thrombin generat ion. (PubMed id 19762781) 1 , 9 Orbe J....PA!ramo J.A. (2009) Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. (PubMed id 16331256) 1 , 9 Aung P.P....Yasui W. (2006) Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases. (PubMed id 9578462) 1 , 9 Nakamura H....Okada Y. (1998) MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. (PubMed id 19601983) 1 , 9 Boyd S....Saarialho-Kere U. (2009) Transcriptional induction of MMP-10 by TGF-beta, medi ated by activation of MEF2A and downregulation of class IIa HDACs. (PubMed id 19935709) 1 , 9 Ishikawa F....Shibanuma M. (2010) Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in M erkel cell carcinoma. (PubMed id 19921252) 1 , 9 Suomela S....Saarialho-Kere U. (2009) Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development. (PubMed id 9662124) 1 , 9 Bord S....Compston J.E. (1998) Activation of human neutrophil procollagenase by stromelysin 2. (PubMed id 8631328) 1 , 9 Knauper V....Tschesche H. (1996) Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulati on in human brain after stroke: a combined laser microdissection and protein ar ray study. (PubMed id 19317417) 1 , 9 Cuadrado E....Montaner J. (2009) C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis. (PubMed id 16580524) 1 , 9 Montero I....Paramo J.A. (2006) Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PubMed id 16054593) 1 , 9 Schnabl B....Scholmerich J. (2005) cDNA cloning and expression of the gene encoding murine stromelysin-2 (MMP-10). (PubMed id 9427548) 1 , 9 Madlener M. and Werner S. (1997) Expression pattern of matrix metalloproteinases in human liver. (PubMed id 7632822) 1 , 9 Lichtinghagen R....Boker K.H. (1995) Beta-carotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism. (PubMed id 15288123) 1 , 9 Wertz K....Goralczyk R. (2004) Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. (PubMed id 8144618) 1 , 9 Gack S....Angel P. (1994) Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes. (PubMed id 10472874) 1 , 9 Fortunato S.J....Lombardi S.J. (1999) Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. (PubMed id 7694569) 1 , 9 Nguyen Q....Roughley P.J. (1993) Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. (PubMed id 1874716) 1 , 9 Fosang A.J....Hamilton J.A. (1991) Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization. (PubMed id 2369069) 1 , 9 Jung J.Y....Rumpler Y. (1990) The role of DNA hypomethylation in the control of stromelysin gene expression. (PubMed id 16516860) 1 , 9 Couillard J....St-Pierre Y. (2006) Application of MMP-7 and MMP-10 in assisting the diagn osis of malignant pleural effusion. (PubMed id 22524815) 1 Cheng D....Li Y.H. (2012) Overexpression of matrix metalloproteinase 10 is assoc iated with poor survival in patients with early stage of esophageal squamous cel l carcinoma. (PubMed id 22121946) 1 Liu H....Guan X.Y. (2012) Synergistic effect of thrombin and CD40 ligand on endo thelial matrix metalloproteinase-10 expression and microparticle generation in v itro and in vivo. (PubMed id 22492089) 1 Martinez de Lizarrondo S....Orbe J. (2012) Matrix metalloproteinase-10 is required for lung cance r stem cell maintenance, tumor initiation and metastatic potential. (PubMed id 22545096) 1 Justilien V....Fields A.P. (2012) Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and c rystal structure. (PubMed id 22427646) 1 Batra J....Radisky E.S. (2012) Genetic variations in matrix metalloproteinases may b e associated with increased risk of ulcerative colitis. (PubMed id 21925226) 1 Morgan A.R....Ferguson L.R. (2011) Type-specific dysregulation of matrix metalloproteina ses and their tissue inhibitors in end-stage heart failure patients: relationsh ip between MMP-10 and LV remodelling. (PubMed id 20219015) 1 Wei Y....Hu S. (2011) Age- and gender-dependent changes in connective tissu e remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 an d TIMP-2 level. (PubMed id 20215736) 1 Komosinska-Vassev K....Olczyk K. (2011) Matrix metalloproteinase-10 promotes Kras-mediated br onchio-alveolar stem cell expansion and lung cancer formation. (PubMed id 22022614) 1 Regala R.P....Fields A.P. (2011) MMP-10/stromelysin-2 promotes invasion of head and ne ck cancer. (PubMed id 21998657) 1 Deraz E.M....Takata T. (2011) Matrix metalloproteinase-10 effectively reduces infar ct size in experimental stroke by enhancing fibrinolysis via a thrombin-activat able fibrinolysis inhibitor-mediated mechanism. (PubMed id 22104553) 1 Orbe J....PA!ramo J.A. (2011) Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilica l vein endothelial cells. (PubMed id 20936527) 1 Mauro A....Gerbino A. (2010) A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000) 1 Liu C.Y....Christiani D.C. (2010) Nitric oxide-mediated invasion in Barrett's high-grad e dysplasia and adenocarcinoma. (PubMed id 20584750) 1 Clemons N.J....Fitzgerald R.C. (2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Association of matrix metalloproteinase gene polymorp hisms with refractive error in Amish and Ashkenazi families. (PubMed id 20484597) 1 Wojciechowski R....Stambolian D. (2010) Interferon gamma receptor 2 gene variants are associa ted with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546) 1 Nalpas B....Abel L. (2010) Expression profiling of ETS and MMP factors in VEGF-a ctivated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis. (PubMed id 20432469) 1 Heo S.H....Cho J.Y. (2010) Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482) 1 Romero R....Menon R. (2010) A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868) 1 Romero R....Menon R. (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) Matrix metalloproteinases (MMP) 1 and MMP10 but not M MP12 are potential oral cancer markers. (PubMed id 19489686) 1 Yen C.Y....Chang H.W. (2009) VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. (PubMed id 18617643) 1 Ha C.H....Jin Z.G. (2008) Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. (PubMed id 17543340) 1 Asano T....Kondo S. (2008) Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. (PubMed id 18035073) 1 Hlatky M.A....Go A.S. (2007) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. (PubMed id 15371548) 1 Krampert M....Werner S. (2004) Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer. (PubMed id 15375490) 1 Lin T.S....Chow K.C. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Clinical potential of matrix metalloprotease inhibito rs in cancer therapy. (PubMed id 10852638) 7 Heath E.I. and Grochow L.B. (2000) Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. (PubMed id 10986281) 1 Nakamura H....Okada Y. (2000) The Protein Data Bank. (PubMed id 10592235) 7 Berman H.M....Bourne P.E. (2000) Matrix metalloproteinases. (PubMed id 10419448) 1 Nagase H. and Woessner J.F. (1999) MMP inhibitors: experimental and clinical studies. (PubMed id 10669951) 7 Belotti D....Giavazzi R. (1999) Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview. (PubMed id 9042108) 1 Chandler S....Gearing A.J. (1997) Activation of type IV procollagenases by human tumor-associated trypsin-2. (PubMed id 9261109) 1 Sorsa T....Stenman U.H. (1997) Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. (PubMed id 8921407) 1 Pendas A.M....Lopez-Otin C. (1996) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994) Human T lymphocytes express a member of the Matrix Metalloproteinase gene family. (PubMed id 8003069) 1 Conca W. and Willmroth F. (1994) Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. (PubMed id 2605216) 1 Sirum K.L. and Brinckerhoff C.E. (1989) IL-6 regulates MMP-10 expression via JAK2/STAT3 signa ling pathway in a human lung adenocarcinoma cell line. (PubMed id 20032397) 9 Zhang X....Xu N. (2009) Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma. (PubMed id 15833553) 9 Seargent J.M....Gill J.H. (2005) Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. (PubMed id 15356104) 9 Van Themsche C....St-Pierre Y. (2004) MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas. (PubMed id 15720804) 9 Gill J.H....Loadman P.M. (2004) Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli. (PubMed id 17981764) 9 Rodriguez J.A....Paramo J.A. (2008) Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. (PubMed id 17059420) 9 Orbe J....Paramo J.A. (2007) Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role. (PubMed id 17207914) 9 Miyata Y....Kanetake H. (2007) Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. (PubMed id 15545168) 9 Salmela M.T....Saarialho-Kere U. (2004) Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. (PubMed id 11237387) 9 Kerkela E....Saarialho-Kere U. (2001) Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. (PubMed id 8463259) 9 Sanchez-Lopez R....Werb Z. (1993) Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells. (PubMed id 18552508) 9 Zhao Y....Heng C.K. (2009) Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines. (PubMed id 11069614) 9 Rechardt O....Saarialho-Kere U. (2000) [The effect of Nifedipine and mechanical strain on ma trix metalloproteinase expression in human periodontal ligament fibroblast] (PubMed id 19769250) 9 Ni H....Sun M. (2009) Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mort ality in sepsis. (PubMed id 19799791) 9 Lorente L....PA!ramo J.A. (2009) Expression of stromelysin and stromelysin-2 in rabbit and human fibroblasts. (PubMed id 1480018) 9 Brinckerhoff C.E....Auble D.T. (1992) Adenovirus-driven overexpression of proteinases in or gan-cultured normal human corneas leads to diabetic-like changes. (PubMed id 19828126) 9 Saghizadeh M....Ljubimov A.V. (2010) Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through mod ulation of MMP-10 expression. (PubMed id 19682763) 9 Tomomatsu T....Akagi Y. (2009) Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (PubMed id 16670920) 9 Dannewitz B....Steinberg T. (2006) Induction of matrix metalloproteinase gene expression in an endothelial cell line by direct interaction with malignant cells. (PubMed id 17054435) 9 Hasebe Y....Nose K. (2007) Disturbances of the expression of metalloproteinases and their tissue inhibitors cause destruction of the basement membrane in pemphigoid. (PubMed id 17019968) 9 Narbutt J....Zebrowska A. (2006) MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. (PubMed id 15870107) 9 Saunders W.B....Davis G.E. (2005) MMP expression profiling in recurred stage IB lung cancer. (PubMed id 14647437) 9 Cho N.H....Cho S.H. (2004) Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. (PubMed id 14977049) 9 Ramos M.C....Brenneisen P. (2004) Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas. (PubMed id 14666700) 9 Thorns V....Thorns C. (2003) Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. (PubMed id 12873452) 9 Kabosova A....Ljubimov A.V. (2003) Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia. (PubMed id 1353052) 9 Colombi M....Barlati S. (1992) Regulation of extracellular matrix remodeling following transforming growth factor-beta1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes. (PubMed id 17587817) 9 Wilkins-Port C.E. and Higgins P.J. (2007) Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications. (PubMed id 12269770) 9 Mathew R....Ralhan R. (2002) Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. (PubMed id 12379519) 9 Tolboom T.C....Huizinga T.W. (2002) Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. (PubMed id 11159210) 9 Saghizadeh M....Ljubimov A.V. (2001) 1alpha,25-dihydroxyvitamin D3 inhibits matrix metallo proteinases induced by Mycobacterium tuberculosis infection. (PubMed id 19178594) 9 Coussens A....Martineau A.R. (2009) Matrix metalloproteinases: discrete elevations in ess ential hypertension and hypertensive end-stage renal disease. (PubMed id 19886850) 9 Friese R.S....O'Connor D.T. (2009) Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. (PubMed id 19220217) 9 Leonardi A....Sack R. (2009) Signal-dependent Regulation of Transcription by Histone Deacetylase 7 Involves Recruitment to Promyelocytic Leukemia Protein Nuclear Bodies. (PubMed id 18463162) 9 Gao C....Kao H.Y. (2008) Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum. (PubMed id 18001410) 9 Bister V....Saarialho-Kere U. (2007) Expression of matrix metalloproteinases 3, 10 and 11 (stromelysins 1, 2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms. Clinicopathologic studies. (PubMed id 16506596) 9 Kren L....Ross J.S. (2006) Molecular balance of capillary tube formation versus regression in wound repair: role of matrix metalloproteinases and their inhibit ors. (PubMed id 17069010) 9 Davis G.E. and Saunders W.B. (2006) Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers. (PubMed id 9710383) 9 Saarialho-Kere U.K. (1998) Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds. (PubMed id 8040294) 9 Saarialho-Kere U.K....Welgus H.G. (1994) The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23. (PubMed id 8486377) 9 Formstone C.J....Taylor A.M. (1993) Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization. (PubMed id 1655673) 9 Polette M....Birembaut P. (1991) (PubMed id 16983356) 9 A study of matrix metalloproteinase expression and ac tivity in atopic dermatitis using a novel skin wash sampling assay for function al biomarker analysis. (PubMed id 19804592) 9 Harper J.I....Chandler S. (2010) Effects of ultrafine TiO2 particles on gene expressio n profile in human keratinocytes without illumination: involvement of extracell ular matrix and cell adhesion. (PubMed id 19695317) 9 Fujita K....Nakanishi J. (2009) Expression of activated signal transducer and activat or of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. (PubMed id 19664131) 9 Lee J....Park C.K. (2009) Clinical and biological significance of CXCR5 express ed by prostate cancer specimens and cell lines. (PubMed id 19610059) 9 Singh S....Lillard J.W. (2009) Polyclonal immunoglobulins (IVIg) induce expression o f MMP-9 in microglia. (PubMed id 19833395) 9 Pul R....Stangel M. (2009) CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcin oma cells. (PubMed id 19723873) 9 Armstrong D.A....Vincenti M.P. (2009) Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease a fter immunosuppressive treatment correlate with histological score and calprote ctin values. (PubMed id 19652986) 9 MAokitalo L....Saarialho-Kere U. (2009) Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans. (PubMed id 19961380) 9 Offenbacher S....Ho B. (2009) Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. (PubMed id 19243594) 9 Eiseler T....Storz P. (2009) Matrix metalloproteinases and their inhibitors: promi sing novel biomarkers in severe sepsis? (PubMed id 20017890) 9 Hoffmann U....Borggrefe M. (2009) Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease. (PubMed id 19080965) 9 PA!ramo J.A....Orbe J. (2008) Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression. (PubMed id 18162290) 9 Li L.B....Zou J.X. (2008) Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconus. (PubMed id 18520507) 9 Maguen E....Ljubimov A.V. (2008) Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. (PubMed id 18391785) 9 Davis G.E. and Senger D.R. (2008) Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. (PubMed id 18268205) 9 Fournie P.R....Fini M.E. (2008) Co-activation of synovial fibroblasts by laminin-111 and transforming growth factor-beta induces expression of matrix metalloproteinases 3 and 10 independently of nuclear factor-kappaB. (PubMed id 17720720) 9 Warstat K....Aicher W.K. (2008) Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls. (PubMed id 18034264) 9 Boyd S....Saarialho-Kere U. (2008) Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. (PubMed id 18442906) 9 Subramaniam R....Mallik S. (2008) The carbon monoxide-releasing molecule tricarbonyldichlororuthenium(II) dimer protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1beta. (PubMed id 18195133) 9 MegA-as J....Alcaraz M.J. (2008) No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. (PubMed id 18768525) 9 Qiu W....He F. (2008) The role of stratifin in fibroblast-keratinocyte interaction. (PubMed id 17646930) 9 Medina A....Ghahary A. (2007) mRNA profiling for body fluid identification by multiplex quantitative RT-PCR. (PubMed id 17868268) 9 Juusola J. and Ballantyne J. (2007) Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187) 9 Vendelin J....Kere J. (2006) A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. (PubMed id 16980307) 9 Abid M.R....Aird W.C. (2006) Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. (PubMed id 16205632) 9 Itoh M....Yoshida K. (2006) Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas. (PubMed id 16265652) 9 Gorogh T....Maune S. (2006) Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections. (PubMed id 17129374) 9 Kanangat S....Schaberg D. (2006) Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas. (PubMed id 16699496) 9 Kuivanen T.T....Saarialho-Kere U.K. (2006) Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. (PubMed id 16677108) 9 Roy S....Sen C.K. (2006) Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis. (PubMed id 15899818) 9 Meyer E....Stamenkovic I. (2005) Response of matrix metalloproteinases and tissue inhibitors of metalloproteinases messenger ribonucleic acids to ovarian steroids in human endometrial explants mimics their gene- and phase-specific differential control in vivo. (PubMed id 16046583) 9 Vassilev V....Henriet P. (2005) Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. (PubMed id 15840104) 9 Impola U....Saarialho-Kere U. (2005) Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells. (PubMed id 15944920) 9 Krikun G....Lockwood C.J. (2005) Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. (PubMed id 16316467) 9 Ritter M....Seither P. (2005) Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. (PubMed id 16186340) 9 Saghizadeh M....Ljubimov A.V. (2005) A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke. (PubMed id 15947272) 9 Rosell A....Montaner J. (2005) Localization of matrix metalloproteinases, (MMPs) their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation. (PubMed id 15868281) 9 Haeusler G....Egerbacher M. (2005) Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities. (PubMed id 15716237) 9 Roebuck M.M....Frostick S.P. (2005) Differential expression of matrix metalloproteinases in viral and non-viral chronic liver diseases. (PubMed id 15469875) 9 Ljumovic D....Kouroumalis E.A. (2004) Expression and functional role of CCR9 in prostate cancer cell migration and invasion. (PubMed id 15623660) 9 Singh S....Lillard J.W. (2004) Expression of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines. (PubMed id 15671765) 9 Baldini E....D'Armiento M. (2004) Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. (PubMed id 15262646) 9 Lo I.K....Frank C.B. (2004) Expression of matrix metalloproteinases in supraglottic carcinoma and its clinical implication for estimating lymph node metastases. (PubMed id 15564854) 9 Xie M....Li Y. (2004) CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. (PubMed id 15467730) 9 Singh S....Lillard J.W. (2004) Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease. (PubMed id 15082589) 9 Kirkegaard T....Brynskov J. (2004) Temporal and spatial expression of matrix metalloprot einases during wound healing of human corneal tissue. (PubMed id 14609553) 9 Daniels J.T....Saarialho-Kere U. (2003) Effects of HDL3 on the expression of matrix-degrading proteases in human endothelial cells. (PubMed id 12792812) 9 Norata G.D....Eriksson P. (2003) Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. (PubMed id 12235077) 9 Salmela M.T....Pender S.L. (2002) C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. (PubMed id 11755824) 9 O-charoenrat P....Eccles S.A. (2002) Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma. (PubMed id 11487270) 9 Salmela M.T....Saarialho-Kere U. (2001) Is the corneal degradation in keratoconus caused by matrix-metalloproteinases? (PubMed id 11778801) 9 Collier S.A. (2001) Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. (PubMed id 11448356) 9 O-Charoenrat P....Eccles S.A. (2001) Metalloelastase (MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors, TIMP-1 and -3, are expressed in psoriatic lesions. (PubMed id 11380613) 9 Suomela S....Saarialho-Kere U. (2001) Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (PubMed id 11247893) 9 Salmela M.T....Saarialho-Kere U. (2001) Expression and activity of matrix metalloproteases in human malignant mesothelioma cell lines. (PubMed id 11267973) 9 Liu Z....Klominek J. (2001) Analysis of matrix metalloproteinase mRNAs expressed in hepatocellular carcinoma cell lines. (PubMed id 11561728) 9 Kim J.H....Lee S.T. (2001) Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts. (PubMed id 11040455) 9 Moore B.A....Windsor L.J. (2000) MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. (PubMed id 11355270) 9 Birkedal-Hansen B....Stetler-Stevenson W.G. (2000) Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints. (PubMed id 11033543) 9 Takei I....Konttinen Y.T. (2000) Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion. (PubMed id 10760816) 9 O-Charoenrat P....Eccles S. (2000) High collagenolytic activity in spontaneously highly metastatic variants derived from a human pancreatic cancer cell line (SUIT-2) in nude mice. (PubMed id 11688961) 9 Kitamura N....Setoguchi T. (2000) Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone. (PubMed id 10071915) 9 Bord S....Compston J.E. (1999) Differential expression of matrix metalloproteinases in bacterial meningitis. (PubMed id 10430840) 9 Kieseier B.C....Hartung H.P. (1999) Purification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors. (PubMed id 10336863) 9 Kannan R....Basset P. (1999) Overview of matrix metalloproteinase expression in cultured human cells. (PubMed id 9550265) 9 Giambernardi T.A....Klebe R.J. (1998) Effect of glucose and heparin on mesangial alpha 1(IV)COLL and MMP-2/TIMP-2 mRNA expression. (PubMed id 9075122) 9 Caenazzo C....Gambaro G. (1997) Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. (PubMed id 8776359) 9 Vaalamo M....Saarialho-Kere U.K. (1996) Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. (PubMed id 8686751) 9 Heppner K.J....Rodgers W.H. (1996) mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in interface tissue around implants in loosening total hip arthroplasty. (PubMed id 8953151) 9 Ishiguro N....Iwata H. (1996) The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family. (PubMed id 7607691) 9 Pendas A.M....Lopez-Otin C. (1995) Neutrophil procollagenase can be activated by stromel ysin-2. (PubMed id 7978810) 9 KnAouper V....Tschesche H. (1994) Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC. (PubMed id 8370623) 9 Alessandro R....Woolley D.E. (1993) Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. (PubMed id 7677979) 9 Muller D....Methlin G. (1993) Isolation and characterization of a high molecular weight type IV collagenase isolated from human carcinoma tissue. (PubMed id 8384126) 9 Tsuda T.T....Tsuda M. (1993) Overproduction of metalloproteinases by v-mos-transfo rmed rat kidney (6m2) cells. (PubMed id 1602817) 9 Chan J.C. (1992) Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas. (PubMed id 1793490) 9 McDonnell S....Matrisian L.M. (1991) TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. (PubMed id 19383899) 9 Wilkins-Port C.E....Higgins P.J. (2009) [Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients] (PubMed id 18214499) 9 Aicher W.K....Gay S. (2008) Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes--expression of extracellular matrix genes and its implications for tendon-healing. (PubMed id 16865710) 9 Molloy T.J....Murrell G.A. (2006) Prognostic significance of stromelysin-3 and tissue inhibitor of matrix metalloproteinase-2 in esophageal cancer. (PubMed id 15557792) 9 Sharma R....Ralhan R. (2004) Differential expression of matrilysin-1 (MMP-7), 92 kD gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer. (PubMed id 14694517) 9 Impola U....Saarialho-Kere U. (2004) Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. (PubMed id 14506071) 9 Bar-Or A.... Yong V.W. (2003) Invasion and metastasis. (PubMed id 8842480) 9 Boyd D. (1996) Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. (PubMed id 7880117) 9 Hembry R.M....Hamblen D.L. (1995)
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About This Section Patent Information for MMP10 gene: Search GeneIP for patents involving MMP10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MMP10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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Browse OriGene Antibodies OriGene shRNA RFP for MMP10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MMP10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMP10 OriGene Protein Over-expression Lysate for MMP10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MMP10 OriGene 3'-UTR Clone for MMP10 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMP10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MMP10 OriGene Custom Protein Services for MMP10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMP10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMP10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MMP10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MMP10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMP10
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MMP10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMP10
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