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MMP10 Gene(Protein Coding)

Matrix Metallopeptidase 10

GCID:
GC11M102770
GIFtS:
68
Genes Participants
UDN Logo

Aliases for MMP10 Gene

Aliases for MMP10 Gene

  • Matrix Metallopeptidase 10 2 3 5
  • Matrix Metalloproteinase 10 (Stromelysin 2) 2 3
  • Matrix Metalloproteinase-10 3 4
  • MMP-10 3 4
  • STMY2 3 4
  • SL-2 3 4
  • Matrix Metalloprotease 10 3
  • Stromelysin 2 2
  • Stromelysin-2 3
  • EC 3.4.24.22 4
  • Transin 2 3
  • Transin-2 4
  • EC 3.4.24 61

External Ids for MMP10 Gene

Previous HGNC Symbols for MMP10 Gene

  • STMY2

Previous GeneCards Identifiers for MMP10 Gene

  • GC11M104834
  • GC11M103998
  • GC11M102675
  • GC11M102178
  • GC11M102146
  • GC11M102641
  • GC11M098569

Summaries for MMP10 Gene

Entrez Gene Summary for MMP10 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP10 Gene

MMP10 (Matrix Metallopeptidase 10) is a Protein Coding gene. Diseases associated with MMP10 include Epidermolysis Bullosa Dystrophica and Keratoconus. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP3.

UniProtKB/Swiss-Prot for MMP10 Gene

  • Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Tocris Summary for MMP10 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP10 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP10 Gene

Genomics for MMP10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MMP10 Gene

Enhancers for MMP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G102727 1.3 FANTOM5 Ensembl ENCODE 11.1 +52.5 52502 1.5 SOX13 HDGF PKNOX1 JUN BACH1 FOSL1 ARID3A ZNF316 GATA2 FOSL2 MMP27 MMP10 MMP1 MMP3 RNU7-159P BIRC2 TMEM123 BIRC3 MMP8 WTAPP1
GH11G102729 1 Ensembl ENCODE 11.1 +50.3 50291 1.9 SOX13 FOXA2 JUN BACH1 TEAD3 RARA FOSL1 ZNF366 RELB FOS MMP27 MMP10 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11G102558 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +220.0 220044 3.4 HDGF TBP PKNOX1 TBL1XR1 FEZF1 ZBTB40 CBX5 ZNF143 RELB ETV6 MMP7 MMP20 ENSG00000256916 BIRC2 MMP10 ANGPTL5 BIRC3
GH11G102733 0.7 ENCODE 11.1 +47.2 47184 0.2 SCRT1 CTCF ZNF654 PKNOX1 TRIM22 REST RAD21 KLF16 TARDBP SCRT2 MMP10 MMP27 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11G102780 0.9 Ensembl ENCODE 0.7 -0.2 -187 1.0 CTCF FOXA2 JUN TEAD4 RAD21 JUND SMC3 FOS TRIM28 MMP3 MMP1 MMP10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMP10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MMP10 gene promoter:

Genomic Location for MMP10 Gene

Chromosome:
11
Start:
102,770,502 bp from pter
End:
102,780,628 bp from pter
Size:
10,127 bases
Orientation:
Minus strand

Genomic View for MMP10 Gene

Genes around MMP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MMP10 Gene

Proteins for MMP10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MMP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09238-MMP10_HUMAN
    Recommended name:
    Stromelysin-2
    Protein Accession:
    P09238
    Secondary Accessions:
    • B2R9X9
    • Q53HH9

    Protein attributes for MMP10 Gene

    Size:
    476 amino acids
    Molecular mass:
    54151 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP10 Gene

neXtProt entry for MMP10 Gene

Protein Expression for MMP10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MMP10 Gene

P09238:
  • HSLGLFH
  • EPEFHLIS
  • PRCGVPD
  • DKYWRFDE
  • YRIVNYT
  • LFLVAAHE
  • IHTLGFP
  • LSFDAISTLRGE
  • HAYPPGPG
  • GEADIMI
  • GTNLFLVA
  • GIQSLYG

Post-translational modifications for MMP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Assay Products

  • Abcam assays for MMP10

Domains & Families for MMP10 Gene

Gene Families for MMP10 Gene

HGNC:
IUPHAR :

Protein Domains for MMP10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MMP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09238

UniProtKB/Swiss-Prot:

MMP10_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP10: view

Function for MMP10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MMP10 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to stromelysin 1, but action on collagen types III, IV and V is weak.
UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP10 Gene

Gene Ontology (GO) - Molecular Function for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP10: view
genes like me logo Genes that share phenotypes with MMP10: view

Animal Models for MMP10 Gene

MGI Knock Outs for MMP10:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP10

CRISPR Products

miRNA for MMP10 Gene

miRTarBase miRNAs that target MMP10

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP10 Gene

Localization for MMP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP10 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA,TAS --
GO:0005615 extracellular space TAS 2844164
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP10: view

Pathways & Interactions for MMP10 Gene

genes like me logo Genes that share pathways with MMP10: view

Pathways by source for MMP10 Gene

1 GeneTex pathway for MMP10 Gene
1 BioSystems pathway for MMP10 Gene
1 GeneGo (Thomson Reuters) pathway for MMP10 Gene

SIGNOR curated interactions for MMP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030334 regulation of cell migration IEA --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with MMP10: view

Drugs & Compounds for MMP10 Gene

Products:

  1. Drug

(8) Drugs for MMP10 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID Experimental Pharma Target 0
Batimastat Experimental Pharma Potent, broad spectrum MMP inhibitor 0
calcium Nutra 0
GI 254023X Pharma Selective inhibitor of ADAM10 metalloprotease, Selective ADAM10 metalloprotease inhibitor 0

(6) Additional Compounds for MMP10 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TMI 1
287403-39-8

(5) Tocris Compounds for MMP10 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor 130370-60-4
GI 254023X Selective ADAM10 metalloprotease inhibitor 260264-93-5
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
TMI 1 Adam 17 (TACE) and MMP inhibitor; orally bioavailable 287403-39-8
WAY 170523 Potent and selective inhibitor of MMP-13 307002-73-9
genes like me logo Genes that share compounds with MMP10: view

Transcripts for MMP10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MMP10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP10 Gene

Matrix metallopeptidase 10 (stromelysin 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP10 Gene

No ASD Table

Relevant External Links for MMP10 Gene

GeneLoc Exon Structure for
MMP10
ECgene alternative splicing isoforms for
MMP10

Expression for MMP10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP10 Gene

mRNA expression in normal human tissues for MMP10 Gene
mRNA expression by BioGPS for MMP10 GenemRNA expression by GTEx for MMP10 Gene

mRNA differential expression in normal tissues according to GTEx for MMP10 Gene

This gene is overexpressed in Vagina (x8.4), Uterus (x7.8), Minor Salivary Gland (x5.9), Prostate (x4.9), Stomach (x4.6), and Lung (x4.3).

Protein differential expression in normal tissues from HIPED for MMP10 Gene

This gene is overexpressed in Urine (54.3) and Synovial fluid (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP10 Gene



Protein tissue co-expression partners for MMP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP10 Gene:

MMP10

SOURCE GeneReport for Unigene cluster for MMP10 Gene:

Hs.2258

Evidence on tissue expression from TISSUES for MMP10 Gene

  • Skin(2.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with MMP10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP10 Gene

Orthologs for MMP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MMP10 34 35
  • 99.3 (n)
mouse
(Mus musculus)
 Mammalia Mmp10 34 16 35
  • 80.35 (n)
rat
(Rattus norvegicus)
 Mammalia Mmp10 34
  • 79.79 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 63 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 52 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves MMP10 34 35
  • 62.74 (n)
-- 35
  • 51 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 51 (a)
 ManyToMany
-- 35
  • 49 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea C31B8.8 36
  • 42 (a)
Species where no ortholog for MMP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP10 Gene

ENSEMBL:
Gene Tree for MMP10 (if available)
TreeFam:
Gene Tree for MMP10 (if available)

Paralogs for MMP10 Gene

Paralogs for MMP10 Gene

(18) SIMAP similar genes for MMP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP10: view

Variants for MMP10 Gene

Sequence variations from dbSNP and Humsavar for MMP10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036139 A breast cancer sample
rs1000374763 -- 102,775,575(+) ATATT(A/G)TGTGT intron-variant
rs1000427322 -- 102,775,760(+) TTTTT(C/T)CAAAA intron-variant
rs1000581070 -- 102,771,161(+) GAGGA(C/T)TCCAT intron-variant
rs1000781216 -- 102,774,926(+) TTTGG(C/T)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP10 Gene

Variant ID Type Subtype PubMed ID
nsv463 CNV insertion 18451855

Variation tolerance for MMP10 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP10 Gene

Human Gene Mutation Database (HGMD)
MMP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP10 Gene

Disorders for MMP10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MMP10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermolysis bullosa dystrophica
  • dystrophic epidermolysis bullosa
keratoconus
  • conical cornea
pyoderma gangrenosum
asymptomatic dengue
middle cerebral artery infarction
  • infarction middle cerebral artery
- elite association - COSMIC cancer census association via MalaCards
Search MMP10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP10

Genetic Association Database (GAD)
MMP10
Human Genome Epidemiology (HuGE) Navigator
MMP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP10
genes like me logo Genes that share disorders with MMP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP10 Gene

Publications for MMP10 Gene

  1. Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PMID: 15095982) Bertini I. … Terni B. (J. Mol. Biol. 2004) 3 4 22 64
  2. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for MMP10 Gene

Sources for MMP10 Gene

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