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MMP10 Gene(Protein Coding)

Matrix Metallopeptidase 10

GCID:
GC11M102770
GIFtS:
55
Genes Participants
UDN Logo

Aliases for MMP10 Gene

Aliases for MMP10 Gene

  • Matrix Metallopeptidase 10 2 3 5
  • Matrix Metalloproteinase 10 (Stromelysin 2) 2 3
  • Matrix Metalloproteinase-10 3 4
  • MMP-10 3 4
  • STMY2 3 4
  • SL-2 3 4
  • Matrix Metalloprotease 10 3
  • Stromelysin 2 2
  • Stromelysin-2 3
  • EC 3.4.24.22 4
  • Transin 2 3
  • Transin-2 4
  • EC 3.4.24 56

External Ids for MMP10 Gene

Previous HGNC Symbols for MMP10 Gene

  • STMY2

Previous GeneCards Identifiers for MMP10 Gene

  • GC11M104834
  • GC11M103998
  • GC11M102675
  • GC11M102178
  • GC11M102146
  • GC11M102641
  • GC11M098569

Summaries for MMP10 Gene

Entrez Gene Summary for MMP10 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP10 Gene

MMP10 (Matrix Metallopeptidase 10) is a Protein Coding gene. Diseases associated with MMP10 include Epidermolysis Bullosa Dystrophica and Pyoderma Gangrenosum. Among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP3.

UniProtKB/Swiss-Prot for MMP10 Gene

  • Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Tocris Summary for MMP10 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP10 Gene

Additional gene information for MMP10 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP10 Gene

Genomics for MMP10 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MMP10 Gene

Promoters and enhancers for MMP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I102780 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.8 -0.2 -186 1 CTCF JUND FOXA2 JUN SMC3 FOSL2 RAD21 TRIM28 MMP10 MMP3 MMP1 WTAPP1
GH11I102727 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.1 +52.5 52502 1.5 JUND JUN FOS MMP8 MMP27 MMP10 MMP1 MMP3 RNU7-159P BIRC2 TMEM123 BIRC3 WTAPP1
GH11I102733 Enhancer 0.7 ENCODE 11.1 +47.2 47183 0.2 MEIS2 CTCF PKNOX1 RAD21 ARID2 SCRT2 SMC3 ZNF143 RUNX3 SCRT1 MMP10 MMP27 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11I102729 Enhancer 0.7 Ensembl ENCODE 11.1 +50.3 50291 1.9 NONO JUN ZNF18 EGR2 MMP27 BIRC2 MMP10 MMP1 MMP3 RNU7-159P MMP8 WTAPP1
GH11I102558 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +220.0 220044 3.4 HDGF PKNOX1 SMAD1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CBFB JUNB MMP7 MMP20 ENSG00000256916 BIRC2 MMP10 ANGPTL5 BIRC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MMP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP10 gene promoter:

Genomic Locations for MMP10 Gene

Genomic Locations for MMP10 Gene
chr11:102,770,502-102,780,628
(GRCh38/hg38)
Size:
10,127 bases
Orientation:
Minus strand
chr11:102,641,233-102,651,359
(GRCh37/hg19)

Genomic View for MMP10 Gene

Genes around MMP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MMP10 Gene

Proteins for MMP10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MMP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09238-MMP10_HUMAN
    Recommended name:
    Stromelysin-2
    Protein Accession:
    P09238
    Secondary Accessions:
    • B2R9X9
    • Q53HH9

    Protein attributes for MMP10 Gene

    Size:
    476 amino acids
    Molecular mass:
    54151 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP10 Gene

neXtProt entry for MMP10 Gene

Protein Expression for MMP10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MMP10 Gene

P09238:
  • HSLGLFH
  • EPEFHLIS
  • PRCGVPD
  • DKYWRFDE
  • YRIVNYT
  • LFLVAAHE
  • IHTLGFP
  • LSFDAISTLRGE
  • HAYPPGPG
  • GEADIMI
  • GTNLFLVA
  • GIQSLYG

Post-translational modifications for MMP10 Gene

No Post-translational modifications

Other Protein References for MMP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MMP10 Gene

Gene Families for MMP10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Protein Domains for MMP10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MMP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09238

UniProtKB/Swiss-Prot:

MMP10_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP10: view

Function for MMP10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MMP10 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to stromelysin 1, but action on collagen types III, IV and V is weak.
UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP10 Gene

Phenotypes From GWAS Catalog for MMP10 Gene

Gene Ontology (GO) - Molecular Function for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP10: view
genes like me logo Genes that share phenotypes with MMP10: view

Animal Models for MMP10 Gene

MGI Knock Outs for MMP10:

Animal Model Products

CRISPR Products

miRNA for MMP10 Gene

miRTarBase miRNAs that target MMP10

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP10 Gene

Localization for MMP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP10 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix TAS,IEA --
GO:0005615 extracellular space TAS 2844164
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP10: view

Pathways & Interactions for MMP10 Gene

genes like me logo Genes that share pathways with MMP10: view

Pathways by source for MMP10 Gene

1 GeneTex pathway for MMP10 Gene
1 BioSystems pathway for MMP10 Gene
1 GeneGo (Thomson Reuters) pathway for MMP10 Gene

SIGNOR curated interactions for MMP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030334 regulation of cell migration IEA --
GO:0030574 collagen catabolic process TAS,IEA --
genes like me logo Genes that share ontologies with MMP10: view

Drugs & Compounds for MMP10 Gene

Products:

  1. Drug

(8) Drugs for MMP10 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
calcium Approved Nutra 0
N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID Experimental Pharma Target 0

(6) Additional Compounds for MMP10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP10 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP10: view

Transcripts for MMP10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MMP10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP10 Gene

Matrix metallopeptidase 10 (stromelysin 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP10 Gene

No ASD Table

Relevant External Links for MMP10 Gene

GeneLoc Exon Structure for
MMP10
ECgene alternative splicing isoforms for
MMP10

Expression for MMP10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP10 Gene

mRNA expression in normal human tissues for MMP10 Gene
mRNA expression by BioGPS for MMP10 GenemRNA expression by GTEx for MMP10 Gene

mRNA differential expression in normal tissues according to GTEx for MMP10 Gene

This gene is overexpressed in Vagina (x8.4), Uterus (x7.8), Minor Salivary Gland (x5.9), Prostate (x4.9), Stomach (x4.6), and Lung (x4.3).

Protein differential expression in normal tissues from HIPED for MMP10 Gene

This gene is overexpressed in Urine (54.3) and Synovial fluid (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP10 Gene



Protein tissue co-expression partners for MMP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP10 Gene:

MMP10

SOURCE GeneReport for Unigene cluster for MMP10 Gene:

Hs.2258

Evidence on tissue expression from TISSUES for MMP10 Gene

  • Skin(2.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with MMP10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP10 Gene

Orthologs for MMP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MMP10 33 34
  • 99.3 (n)
mouse
(Mus musculus)
 Mammalia Mmp10 33 16 34
  • 80.35 (n)
rat
(Rattus norvegicus)
 Mammalia Mmp10 33
  • 79.79 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 63 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 52 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves MMP10 33 34
  • 62.74 (n)
-- 34
  • 51 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 51 (a)
 ManyToMany
-- 34
  • 49 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea C31B8.8 35
  • 42 (a)
Species where no ortholog for MMP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP10 Gene

ENSEMBL:
Gene Tree for MMP10 (if available)
TreeFam:
Gene Tree for MMP10 (if available)

Paralogs for MMP10 Gene

Paralogs for MMP10 Gene

(18) SIMAP similar genes for MMP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP10: view

Variants for MMP10 Gene

Sequence variations from dbSNP and Humsavar for MMP10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_036139 A breast cancer sample p.Glu142Gln
rs1000374763 -- 102,775,575(-) A/G intron_variant
rs1000427322 -- 102,775,760(-) C/T intron_variant
rs1000581070 -- 102,771,161(-) C/T intron_variant
rs1000781216 -- 102,774,926(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP10 Gene

Variant ID Type Subtype PubMed ID
nsv463 CNV insertion 18451855

Variation tolerance for MMP10 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP10 Gene

Human Gene Mutation Database (HGMD)
MMP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP10 Gene

Disorders for MMP10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MMP10 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermolysis bullosa dystrophica
  • dystrophic epidermolysis bullosa
pyoderma gangrenosum
asymptomatic dengue
keratoconus
  • conical cornea
septic arthritis
  • infectious arthritis
- elite association - COSMIC cancer census association via MalaCards
Search MMP10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP10 Gene

Publications for MMP10 Gene

  1. Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PMID: 15095982) Bertini I … Terni B (Journal of molecular biology 2004) 3 4 22 58
  2. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for MMP10 Gene

Sources for MMP10 Gene

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