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MMP10 Gene

protein-coding GIFtS: 72
GCID: GC11M102641

Matrix Metallopeptidase 10 (Stromelysin 2)

(Previous name: matrix metalloproteinase 10 (stromelysin 2))
(Previous symbol: STMY2)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Matrix Metallopeptidase 10 (Stromelysin 2)¹ ²		Stromelysin 2²
STMY2¹ ² ³ ⁵		stromelysin-2²
Matrix Metalloproteinase 10 (Stromelysin 2)¹ ²		Transin 2²
Matrix Metalloproteinase-10² ³		transin-2²
MMP-10² ³		EC 3.4.24.22³
SL-2² ³		Transin-2³
Matrix Metalloprotease 10²		EC 3.4.24⁸

External Ids:	HGNC: 7156¹	Entrez Gene: 4319²	Ensembl: ENSG00000166670⁷	OMIM: 185260⁵	UniProtKB: P09238³

Export aliases for MMP10 gene to outside databases

Previous GC identifers: GC11M104834 GC11M103998 GC11M102675 GC11M102178 GC11M102146 GC11M098569

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP10 Gene:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in

normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in

disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are

activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and

fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by

RefSeq, Jul 2008)

GeneCards Summary for MMP10 Gene:

MMP10 (matrix metallopeptidase 10 (stromelysin 2)) is a protein-coding gene. Diseases associated with MMP10 include mast cell neoplasm, and refractive error. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238

Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates

procollagenase

summary for MMP10 Gene:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP10 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000011.10 NC_018922.2 NT_033899.9

Regulatory elements:

Regulatory transcription factor binding sites in the MMP10 gene promoter:
CREB SRF AP-1 deltaCREB ATF-2 SRF (504 AA) c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP10 promoter sequence

Search Chromatin IP Primers for MMP10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3

MMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP10 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102641: view genomic region (about GC identifiers)

Start:	102,641,233 bp from pter	End:	102,651,359 bp from pter
Size:	10,127 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 (See protein sequence)

Recommended Name: Stromelysin-2 precursor

Size: 476 amino acids; 54151 Da

Cofactor: Binds 2 zinc ions per subunit

Cofactor: Calcium

3 PDB 3D structures from and Proteopedia for MMP10:

1Q3A (3D)

3V96 (3D)

4ILW (3D)

Secondary accessions: B2R9X9 Q53HH9

Explore the universe of human proteins at neXtProt for MMP10: NX_P09238

Explore proteomics data for MMP10 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for MMP10 (P09238) (see all 12)

HSLGLFH

GEADIMI

GIQSLYG

YRIVNYT

See MMP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002416.1

ENSEMBL proteins:

ENSP00000279441 ENSP00000441485

Reactome Protein details: P09238

MMP10 Human Recombinant Protein Products:

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	Novus Biologicals MMP10 Proteins Novus Biologicals MMP10 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MMP10

MMP10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP10
	R&D Systems Antibodies for MMP10 (MMP-10)
	OriGene Antibodies for MMP10 OriGene Custom Antibody Services for MMP10
	Novus Biologicals MMP10 Antibodies
	Abcam antibodies for MMP10
	Cloud-Clone Corp. Antibodies for MMP10
	ThermoFisher Antibody for MMP10
	LSBio Antibodies in human, mouse, rat for MMP10

MMP10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MMP10
	R&D Systems ELISAs for MMP10 (MMP-10) (see all)
	GenScript MMP10-Activity-based Protease?src=genec Assay for Compound Screening
	Enzo Life Sciences assays for MMP10
	Cloud-Clone Corp. ELISAs for MMP10 Cloud-Clone Corp. CLIAs for MMP10

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: MMP10

Cell-surface protein and extracellular matrix metalloproteinases

Selected InterPro protein domains (see all 11):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A

IPR000585 Hemopexin-like_dom

IPR018486 Hemopexin_CS

Graphical View of Domain Structure for InterPro Entry P09238

ProtoNet protein and cluster: P09238

3 Blocks protein domains:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting

the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the

enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin repeats

MMP10 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MMP10_HUMAN, P09238

Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates

procollagenase

Catalytic activity: Similar to stromelysin 1, but action on collagen types III, IV and V is weak

Genatlas biochemistry entry for MMP10:

matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone

Enzyme Numbers (IUBMB): EC 3.4.24² EC 3.4.24.22¹

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008237	metallopeptidase activity	--	--
GO:0008270	zinc ion binding	IEA	--

MMP10 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MMP10:

Proliferating cells

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp10):

cardiovascular system

immune system

normal

respiratory system

MMP10 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for MMP10: Mmp10^tm1Jkmg Mmp10^tm1Lex

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP10

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP10

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP10

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP10

miRNA Products:		miRTarBase miRNAs that target MMP10: hsa-mir-26b-5p (MIRT028865)

		Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate MMP10:
		hsa-miR-496
		SwitchGear 3'UTR luciferase reporter plasmid: MMP10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MMP10
		Predesigned siRNA for gene silencing in human, mouse, rat MMP10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP10

Clone Products:		OriGene clones in human, mouse for MMP10 (see all 6) OriGene ORF clones in mouse, rat for MMP10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
		Sino Biological Human cDNA Clone for MMP10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP10
		ESI BIO PureStem Progenitor for MMP10: PureStem 7SMOO32, NCr-fac & Meso Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MMP10_HUMAN, P09238: Secreted, extracellular space, extracellular matrix (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	4
endoplasmic reticulum	2
nucleus	2
plasma membrane	2
cytoskeleton	1
cytosol	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	2844164
GO:0031012	extracellular matrix	--	--

MMP10 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MMP10 About

See pathways by source

SuperPath

Contained pathways About

Matrix Metalloproteinases

	Matrix Metalloproteinases	0.68			Activation of Matrix Metalloproteinases	0.37
	Inhibition of Matrix Metalloproteinases	0.68

Cell adhesion ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Cell adhesion ECM remodeling

0.31

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	0.43			Extracellular matrix organization	0.34
	Collagen degradation	0.43

Integrin Pathway

UPA-UPAR Pathway

0.56

Transendothelial Migration of Leukocytes

0.38

GPCR Pathway

Pancreatic Adenocarcinoma

0.59

Pathways by source See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP10

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 GeneGo (Thomson Reuters) Pathway for MMP10

Cell adhesion ECM remodeling

1 BioSystems Pathway for MMP10

Matrix Metalloproteinases

3 Reactome Pathways for MMP10

	Degradation of the extracellular matrix
	Collagen degradation
	Activation of Matrix Metalloproteinases

MMP10 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including MMP10:

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Tumor Metastasis in human mouse rat

Interactions:

GeneGlobe Interaction Network for MMP10

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for MMP10 (P09238³ ENSP00000279441⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HAPLN1	P10915³, ENSP00000274341⁴	I2D: score=1 STRING: ENSP00000274341
MMP9	P14780³, ENSP00000361405⁴	I2D: score=1 STRING: ENSP00000361405
BCAN	Q96GW7³, ENSP00000331210⁴	I2D: score=2 STRING: ENSP00000331210
MMP1	ENSP00000322788⁴	STRING: ENSP00000322788
MMP2	ENSP00000219070⁴	STRING: ENSP00000219070

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	2844164
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030334	regulation of cell migration	IEA	--
GO:0030574	collagen catabolic process	TAS	--

MMP10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for MMP10

Browse compounds at ApexBio

Compounds for MMP10 available from Tocris Bioscience About this table

Compound	Action	CAS #
GI 254023X	Selective ADAM10 metalloprotease inhibitor	[260264-93-5]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
GM 6001	Broad-spectrum MMP inhibitor	[142880-36-2]
UK 383367	Potent and selective BMP-1 (PCP) inhibitor	[348622-88-8]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]

1 HMDB Compound for MMP10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 DrugBank Compounds for MMP10 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	antagonist	10852638 10669951
N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID	--	--	target	--	10592235

7 Novoseek inferred chemical compound relationships for MMP10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate	74.2	1	9578462 (1)
matrigel	22.8	1	12379519 (1)
12-o-tetradecanoylphorbol 13-acetate	9.97	1	8144618 (1)
serine	8.4	6	15870107 (3), 19762781 (1), 16983356 (1), 17069010 (1)
vegf	4.55	3	15868281 (1), 16980307 (1), 19220217 (1)
oligonucleotide	0	2	8269280 (1), 9550265 (1)
calcium	0	2	19769250 (1)

MMP10 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MMP10 gene:

NM_002425.2

Unigene Cluster for MMP10:

Matrix metallopeptidase 10 (stromelysin 2)

Hs.2258 [show with all ESTs]

Unigene Representative Sequence: NM_002425

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000279441(uc001phg.2) ENST00000539681

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate MMP10:
		hsa-miR-496
		SwitchGear 3'UTR luciferase reporter plasmid: MMP10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MMP10
		Predesigned siRNA for gene silencing in human, mouse, rat MMP10

Clone Products:		OriGene clones in human, mouse for MMP10 (see all 6) OriGene ORF clones in mouse, rat for MMP10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

Primer Products:		OriGene qPCR primer pairs and template standards for MMP10 OriGene qSTAR qPCR primer pairs in human, mouse for MMP10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MMP10
		QuantiTect SYBR Green Assays in human, mouse, rat MMP10
		QuantiFast Probe-based Assays in human, mouse, rat MMP10

Additional mRNA sequence:

AK222601.1 AK313960.1 BC002591.2 BT007442.1 X07820.1

5 DOTS entries:

DT.106379 DT.120702938 DT.120702949 DT.99929471 DT.313463

Selected AceView cDNA sequences (see all 56):

BP350564 BP350592 BP352531 AW949366 BP351427 BT007442 BP351309 BE740153

BP351724 BP351322 BP352568 BX281044 AI973162 BC002591 NM_002425 X07820

BP351604 BP352259 CF596568 CB528312 BP351299 BF034537 BM480245 BP351055

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MMP10 expression in normal human tissues (normalized intensities) MMP10 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MMP10 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Placenta (Extraembryonic Tissues) fully expand to see all 2 entries
Placenta-derived mesenchymal stem cells (family)

Mesenchymal Stem Cells (Uncategorized) fully expand to see all 2 entries
Placenta-derived mesenchymal stem cells (family)

Neural Crest (Gastrulation Derivatives)
PureStem 7SMOO32, NCr-fac & Meso Progenitor

Epidermis (Integumentary System)
MSC-containing human skin substitute (Grafix)

Umbilical Cord (Extraembryonic Tissues)
Wharton's jelly-derived stem cells

MMP10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MMP10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2258

Pathway & Disease-focused RT² Profiler PCR Arrays including MMP10:

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Tumor Metastasis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for MMP10 OriGene qSTAR qPCR primer pairs in human, mouse for MMP10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MMP10
		QuantiTect SYBR Green Assays in human, mouse, rat MMP10
		QuantiFast Probe-based Assays in human, mouse, rat MMP10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MMP10 gene from 8 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	MMP10¹	matrix metallopeptidase 10 (stromelysin 2)	99.3(n) 98.95(a)		740658 XM_001153881.1 XP_001153881.1
mouse (Mus musculus)	Mammalia	Mmp10^{1 , 5}	matrix metallopeptidase 10^{1, 5}	80.35(n)¹ 76.42(a)¹		9 (2.46 cM)⁵ 17384¹ NM_019471.2¹ NP_062344.1¹ 7502360⁵
rat (Rattus norvegicus)	Mammalia	Mmp10¹	matrix metallopeptidase 10 (stromelysin 2)	79.79(n) 75.58(a)		117061 NM_133514.1 NP_598198.1
oppossum (Monodelphis domestica)	Mammalia	--	Uncharacterized protein	63(a)	1 → many	4(259416147-259428855)
platypus (Ornithorhynchus anatinus)	Mammalia	--	Uncharacterized protein	52(a)	1 → many	Ultra192(2143752-2152676)
chicken (Gallus gallus)	Aves	MMP10¹	matrix metallopeptidase 10 (stromelysin 2)	62.74(n) 55.25(a)		418981 NM_001278089.1 NP_001265018.1
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	51(a) 49(a)	many ↔ many many ↔ many	3(192100483-192115896) 3(192049389-192058962)
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	42(a)		V(2905685-2909407) --

Species with no ortholog for MMP10

ENSEMBL Gene Tree for MMP10 (if available)
TreeFam Gene Tree for MMP10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MMP10 gene

MMP20² MMP13² MMP8² MMP14² MMP25² MMP16² MMP7² MMP24²

MMP15² MMP3² MMP27² MMP11² MMP17² MMP1²

18 SIMAP similar genes for MMP10 using alignment to 2 protein entries: MMP10_HUMAN (see all proteins):

MMP3 MMP1 MMP13 MMP12 MMP27 MMP8

MMP20 MMP7 MMP2 MMP26 MMP17 MMP14

MMP11 MMP16 MMP19 MMP24 MMP25 MMP15

MMP10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036139⁴		A breast cancer sample⁴	--	see VAR_036139	2	E Q	mis⁴		0	--	--	--	--
rs185511859^1,2		--	102640800(+)	`TGAGGC/GGGAGA`	1	--	ds500¹		0	--	--	--	--
rs11225418^1,2	C,F,A,H	--	102640805(+)	`GGGAGA/CTGAGA`	1	--	ds500¹		19		NS EA NA WA	1416
rs17861016^1,2	C,F	--	102640838(-)	`GTGGGA/TTTCCT`	1	--	ds500¹		8		NS NA CSA	312
rs188821615^1,2		--	102640882(+)	`TGGACA/TCCAAA`	1	--	ds500¹		0	--	--	--	--
rs193045112^1,2	C	--	102640935(+)	`ATAATA/GTGCAG`	1	--	ds500¹		0	--	--	--	--
rs17861015^1,2	C	--	102640969(-)	`GAAATG/TGAACT`	1	--	ds500¹		1		NS	180
rs148458419^1,2		--	102641024(+)	`TTACCC/TCTTTC`	1	--	ds500¹		0	--	--	--	--
rs115232736^1,2	F	--	102641042(+)	`GGTGTG/ATAAGG`	1	--	ds500¹		1		WA	118
rs143889687^1,2		--	102641061(+)	`CAATAA/TCTGTG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MMP10 (102641233 - 102651359 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for MMP10: About this table

Variant ID	Type	Subtype	PubMed ID
nsv463	CNV	Insertion	18451855

Human Gene Mutation Database (HGMD): MMP10

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MMP10

DNA2.0 Custom Variant and Variant Library Synthesis for MMP10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 185260 OMIM disorders: --

Selected diseases for MMP10 (see all 66): About MalaCards

mast cell neoplasm refractive error epidermolysis bullosa dystrophica encephalomyelitis

keratoconus pyoderma gangrenosum vernal keratoconjunctivitis pyoderma

bladder transitional cell carcinoma keratoacanthoma arthritis richter's syndrome

gingival overgrowth transitional cell carcinoma keratoconjunctivitis squamous cell carcinoma of the head and neck

abdominal aortic aneurysm epidermolysis bullosa gingivitis gastric adenocarcinoma

2 diseases from the University of Copenhagen DISEASES database for MMP10:

Lymphoma Mast cell neoplasm

MMP10 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for MMP10 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
invasive cancer	48.3	1	19601983 (1)
squamous cell cancer	47.3	2	19601983 (1)
hnscc	43.4	1	16265652 (1)
carcinoma squamous cell	42.6	7	12269770 (2), 17587817 (1), 14977049 (1), 11237387 (1)
tumors	38.3	61	15833553 (5), 17695449 (4), 15720804 (3), 15356104 (2) (see all 20)
metastasis	37	5	11487270 (1), 15557792 (1), 19921252 (1), 17695449 (1) (see all 5)
keratoconus	37	1	11778801 (1)
venous ulcer	34.3	3	11069614 (2), 8776359 (1)
skin cancer	25.5	3	19601983 (1), 11237387 (1)
carcinoma	24.1	7	1655673 (2), 7677979 (1), 1793490 (1), 11237387 (1)

Genetic Association Database (GAD): MMP10
Human Genome Epidemiology (HuGE) Navigator: MMP10 (12 documents)

Export disorders for MMP10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MMP10 gene, integrated from 10 sources (see all 206):
(articles sorted by number of sources associating them with MMP10)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PubMed id 15095982)^{1, 2, 9} Bertini I....Terni B. (J. Mol. Biol. 2004)
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)^{1, 4, 9} Ogata T....Kuivaniemi H. (J. Vasc. Surg. 2005)
A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)^{1, 4} Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)^{1, 4} Nalpas B....Abel L. (Gut 2010)
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. (PubMed id 18035073)^{1, 4} Hlatky M.A....Go A.S. (Am. Heart J. 2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The collagenase gene family in humans consists of at least four members. (PubMed id 2844164)^{1, 2} Muller D....Breathnach R. (Biochem. J. 1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4319	HGNC: 7156	AceView: MMP10	Ensembl:ENSG00000166670	euGenes: HUgn4319
ECgene: MMP10	H-InvDB: MMP10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MMP10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP10	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp10/

Intellectual Property for MMP10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP10 gene:
Search GeneIP for patents involving MMP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Matrix Metallopeptidase 10 (Stromelysin 2)

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Matrix Metallopeptidase 10 (Stromelysin 2)

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