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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP10 Gene

protein-coding GIFtS: 71
GCID: GC11M102641

matrix metallopeptidase 10 (stromelysin 2)

(Previous name: matrix metalloproteinase 10 (stromelysin 2) )
(Previous symbol: STMY2)

Explore 66 diseases affiliated with
MMP10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 10 (Stromelysin 2)¹ ²		Stromelysin 2²
STMY2¹ ² ³ ⁵		Stromelysin-2¹
Matrix Metalloproteinase 10 (Stromelysin 2)¹ ²		Transin 2²
Matrix Metalloproteinase-10² ³		Transin-2³
MMP-10² ³		EC 3.4.24.22³
SL-2² ³		Transin-2³
Matrix Metalloprotease 10²		EC 3.4.24⁸

External Ids:	HGNC: 7156¹	Entrez Gene: 4319²	Ensembl: ENSG00000166670⁷	OMIM: 185260⁵	UniProtKB: P09238³

Export aliases for MMP10 gene to outside databases

Previous GC identifers: GC11M104834 GC11M103998 GC11M102675 GC11M102178 GC11M102146 GC11M098569

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP10:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene

is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238

Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates

procollagenase

summary for MMP10:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP10 gene promoter:
CREB SRF AP-1 deltaCREB ATF-2 SRF (504 AA) c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MMP10 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22.3

MMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP10 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102641: view genomic region (about GC identifiers)

Start:	102,641,233 bp from pter	End:	102,651,359 bp from pter
Size:	10,127 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 (See protein sequence)

Recommended Name: Stromelysin-2 precursor

Size: 476 amino acids; 54151 Da

Cofactor: Binds 2 zinc ions per subunit

Cofactor: Calcium

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

2 PDB 3D structures from and Proteopedia for MMP10:

1Q3A (3D)

3V96 (3D)

Secondary accessions: B2R9X9 Q53HH9

Explore the universe of human proteins at neXtProt for MMP10: NX_P09238

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09238

4/12 DME Specific Peptides for MMP10 (P09238) (see all 12)

HSLGLFH

GEADIMI

GIQSLYG

YRIVNYT

MMP10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002416.1

ENSEMBL proteins:

ENSP00000279441 ENSP00000441485

Reactome Protein details: P09238
Human Recombinant Protein Products:

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	Novus Biologicals MMP10 Proteins Novus Biologicals MMP10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MMP10

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	2844164
GO:0031012	extracellular matrix	--	--

MMP10 for ontologies About GeneDecksing

MMP10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for MMP10
	Novus Biologicals MMP10 Antibodies
	Abcam antibodies for MMP10
	Uscn Antibodies for MMP10
	ThermoFisher Antibodies for MMP10

Assay Products for MMP10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP10 (MMP-10) (see all)
	GenScript MMP10-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP10
	Uscn ELISAs and CLIAs for MMP10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP10 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P09238

ProtoNet protein and cluster: P09238

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238

Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates

procollagenase

Catalytic activity: Similar to stromelysin 1, but action on collagen types III, IV and V is weak

Genatlas biochemistry entry for MMP10:

matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone

Enzyme Numbers (IUBMB): EC 3.4.24² EC 3.4.24.22¹

miRNA Products:		OriGene 3'-UTR Clone: MMP10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP10
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP10:
		hsa-miR-496
		SwitchGear 3'UTR luciferase reporter plasmid: MMP10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP10 (see all 7) OriGene shRNA RFP: MMP10 OriGene siRNA: MMP10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MMP10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
		Sino Biological Human cDNA Clone for MMP10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP10
		LifeMap BioReagents: cell line associated with MMP10: PureStem 7SMOO32, NCr-fac & Meso Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MMP10:

Proliferating cells

Animal Models:
Mouse knock-outs for MMP10: Mmp10^tm1Jkmg Mmp10^tm1Lex
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mmp10):

cardiovascular system

immune system

normal

respiratory system

MMP10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Cell adhesion_ECM remodeling

	Cell adhesion_ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion ECM remodeling	1.00

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Inhibition of Matrix Metalloproteinases

0.68

Integrin Pathway

UPA-UPAR Pathway

0.51

Transendothelial Migration of Leukocytes

0.38

Activation of proMMP10

Activation of proMMP10

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MMP10

	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP10

	Inhibition of Matrix Metalloproteinases
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

1 GeneGo (Thomson Reuters) Pathway for MMP10

Cell adhesion ECM remodeling

1 BioSystems Pathway for MMP10

Matrix Metalloproteinases

5 Reactome Pathways for MMP10

	Extracellular matrix organization
	Activation of proMMP10
	Degradation of the extracellular matrix
	Degradation of collagen
	Activation of Matrix Metalloproteinases

MMP10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP10

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for MMP10 (P09238³ ENSP00000279441⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HAPLN1	P10915³, ENSP00000274341⁴	I2D: score=1 STRING: ENSP00000274341
MMP9	P14780³, ENSP00000361405⁴	I2D: score=1 STRING: ENSP00000361405
BCAN	Q96GW7³, ENSP00000331210⁴	I2D: score=2 STRING: ENSP00000331210
MMP1	ENSP00000322788⁴	STRING: ENSP00000322788
MMP2	ENSP00000219070⁴	STRING: ENSP00000219070

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0030334	regulation of cell migration	IEA	--
GO:0030574	collagen catabolic process	IEA	--

MMP10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP10 for compounds About GeneDecksing

EMD Millipore small molecules for MMP10:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP10

Compounds for MMP10 available from Tocris Bioscience About this table

Compound	Action	CAS #
CP 471474	Broad spectrum MMP inhibitor	[210755-45-6]
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]

1 HMDB Compound for MMP10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca Calcium element (see top 1)	7440-70-2	--

2 DrugBank Compounds for MMP10 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	antagonist	10852638 10669951
N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID	--	--	target	--	10592235

7 Novoseek chemical compound relationships for MMP10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
(4-aminophenyl)mercuric acetate	74.2	1	9578462 (1)
matrigel	22.8	1	12379519 (1)
12-o-tetradecanoylphorbol 13-acetate	9.97	1	8144618 (1)
serine	8.4	6	15870107 (3), 19762781 (1), 16983356 (1), 17069010 (1)
vegf	4.55	3	15868281 (1), 16980307 (1), 19220217 (1)
oligonucleotide	0	2	8269280 (1), 9550265 (1)
calcium	0	2	19769250 (1)

Search CenterWatch for drugs/clinical trials and news about MMP10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP10 gene:

NM_002425.2

Unigene Cluster for MMP10:

Matrix metallopeptidase 10 (stromelysin 2)

Hs.2258 [show with all ESTs]

Unigene Representative Sequence: NM_002425

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000279441(uc001phg.2) ENST00000539681

miRNA Products:		OriGene 3'-UTR Clone: MMP10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP10
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP10:
		hsa-miR-496
		SwitchGear 3'UTR luciferase reporter plasmid: MMP10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP10 (see all 7) OriGene shRNA RFP: MMP10 OriGene siRNA: MMP10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP10

Additional cDNA sequence:

AK222601.1 AK313960.1 BC002591.2 BT007442.1 X07820.1

5 DOTS entries:

DT.106379 DT.120702938 DT.120702949 DT.313463 DT.99929471

24/56 AceView cDNA sequences (see all 56):

BP350564 BP351427 BE740153 BT007442 BP351309 BC002591 BP351604 BP350592

BP352568 NM_002425 BP352531 AW949366 BX281044 BP351322 BP351724 X07820

AI973162 BP352259 CB528312 BP352575 CF596568 T27816 BP352805 BF034537

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MMP10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MMP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP10

SOURCE GeneReport for Unigene cluster: Hs.2258

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP10:

Osteogenesis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Tumor Metastasis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP10 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP10¹	matrix metallopeptidase 10 (stromelysin 2)	62.55(n) 54.68(a)		418981 XM_417175.2 XP_417175.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	53(a) 49(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(192100693-192114354) 3(192049443-192058710)
zebrafish (Danio rerio)	Actinopterygii	mmp30¹	matrix metallopeptidase 30	53.12(n) 43.87(a)		678531 NM_001040291.1 NP_001035381.1
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	42(a)		V(2905685-2909407) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT1G59970⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	26(a) 26(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 1(22073534-22074876)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	8(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 2(30974996-30977090)

ENSEMBL Gene Tree for MMP10 (if available)
TreeFam Gene Tree for MMP10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP10 gene

MMP13² MMP20² MMP8² MMP14² MMP9² MMP16² MMP2² MMP25²

MMP24² MMP15² MMP11² MMP3² MMP27² MMP17² MMP1²

18 SIMAP similar genes for MMP10 using alignment to 2 protein entries: MMP10_HUMAN (see all proteins):

MMP3 MMP1 MMP13 MMP12 MMP27 MMP8

MMP20 MMP7 MMP2 MMP26 MMP17 MMP14

MMP11 MMP16 MMP19 MMP24 MMP25 MMP15

MMP10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185511859^1,2		--	102640800(+)	`TGAGGC/GGGAGA`	1	--	ds500¹		0	--	--	--	--
rs11225418^1,2	C,F,A,H,	--	102640805(+)	`GGGAGA/CTGAGA`	1	--	ds500¹		19		NS EA NA WA	1416
rs17861016^1,2	C,F,	--	102640838(-)	`GTGGGA/TTTCCT`	1	--	ds500¹		8		NS NA CSA	312
rs188821615^1,2		--	102640882(+)	`TGGACA/TCCAAA`	1	--	ds500¹		0	--	--	--	--
rs193045112^1,2		--	102640935(+)	`ATAATA/GTGCAG`	1	--	ds500¹		0	--	--	--	--
rs17861015^1,2	C	--	102640969(-)	`GAAATG/TGAACT`	1	--	ds500¹		1		NS	180
rs148458419^1,2		--	102641024(+)	`TTACCC/TCTTTC`	1	--	ds500¹		0	--	--	--	--
rs115232736^1,2		--	102641042(+)	`GGTGTG/ATAAGG`	1	--	ds500¹		1		WA	118
rs143889687^1,2		--	102641061(+)	`CAATAA/TCTGTG`	1	--	ds500¹		0	--	--	--	--
rs17861014^1,2	C,F,	--	102641172(-)	`ACAGAT/GAGTCT`	1	--	ds500¹		10		NS NA CSA EA	466

HapMap Linkage Disequilibrium report for MMP10 (102641233 - 102651359 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP10: --
Human Gene Mutation Database (HGMD): MMP10

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP10

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP10 for disorders           About GeneDecksing

OMIM gene information: 185260    OMIM disorders: --

20/66 diseases for MMP10 (see all 66):    About MalaCards

epidermolysis bullosa dystrophica arthritis encephalomyelitis epidermolysis bullosa

refractive error pyoderma gangrenosum abdominal aortic aneurysm mast cell neoplasm

vernal keratoconjunctivitis aortic aneurysm bladder transitional cell carcinoma transitional cell carcinoma

pyoderma squamous cell carcinoma gingival overgrowth myocardial infarction

acute myocardial infarction squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma keratoconjunctivitis

2 diseases from the University of Copenhagen DISEASES database for MMP10:

Mast cell neoplasm Lymphoma

10/24 Novoseek disease relationships for MMP10 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
invasive cancer	48.3	1	19601983 (1)
squamous cell cancer	47.3	2	19601983 (1)
hnscc	43.4	1	16265652 (1)
carcinoma squamous cell	42.6	7	12269770 (2), 17587817 (1), 14977049 (1), 11237387 (1)
tumors	38.3	61	15833553 (5), 17695449 (4), 15720804 (3), 15356104 (2) (see all 20)
metastasis	37	5	11487270 (1), 15557792 (1), 19921252 (1), 17695449 (1) (see all 5)
keratoconus	37	1	11778801 (1)
venous ulcer	34.3	3	11069614 (2), 8776359 (1)
skin cancer	25.5	3	19601983 (1), 11237387 (1)
carcinoma	24.1	7	1655673 (2), 7677979 (1), 1793490 (1), 11237387 (1)

Genetic Association Database (GAD): MMP10
Human Genome Epidemiology (HuGE) Navigator: MMP10 (12 documents)

Export disorders for MMP10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MMP10 gene, integrated from 9 sources (see all 198):
(articles sorted by number of sources associating them with MMP10)

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Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PubMed id 15095982)^{1, 2, 9} Bertini I....Terni B. (2004)
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)^{1, 4, 9} Ogata T....Kuivaniemi H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The collagenase gene family in humans consists of at least four members. (PubMed id 2844164)^{1, 2} Muller D....Breathnach R. (1988)
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. (PubMed id 17009259)^{1, 9} Barksby H.E....Rowan A.D. (2006)
Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral di sc. (PubMed id 19695094)^{1, 9} Richardson S.M....Hoyland J.A. (2009)
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. (PubMed id 18427549)^{1, 9} Frederick L.A....Fields A.P. (2008)
Expression of MMP-10 in lung cancer. (PubMed id 17695449)^{1, 9} Zhang X....Xu N. (2007)
Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. (PubMed id 8349617)^{1, 9} Windsor L.J....Birkedal-Hansen H. (1993)
Matrix metalloproteinase-10 is upregulated by thrombi n in endothelial cells and increased in patients with enhanced thrombin generat ion. (PubMed id 19762781)^{1, 9} Orbe J....PA!ramo J.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4319	HGNC: 7156	AceView: MMP10	Ensembl:ENSG00000166670	euGenes: HUgn4319
ECgene: MMP10	H-InvDB: MMP10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MMP10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP10	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp10/

Intellectual Property for MMP10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MMP10 gene:
Search GeneIP for patents involving MMP10

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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matrix metallopeptidase 10 (stromelysin 2)

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matrix metallopeptidase 10 (stromelysin 2)

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