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MMP10 Gene

protein-coding   GIFtS: 72
GCID: GC11M102641

Matrix Metallopeptidase 10 (Stromelysin 2)

(Previous name: matrix metalloproteinase 10 (stromelysin 2))
(Previous symbol: STMY2)
  See MMP10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 10 (Stromelysin 2)1 2     Stromelysin 22
STMY21 2 3 5     stromelysin-22
Matrix Metalloproteinase 10 (Stromelysin 2)1 2     Transin 22
Matrix Metalloproteinase-102 3     transin-22
MMP-102 3     EC 3.4.24.223
SL-22 3     Transin-23
Matrix Metalloprotease 102     EC 3.4.248

External Ids:    HGNC: 71561   Entrez Gene: 43192   Ensembl: ENSG000001666707   OMIM: 1852605   UniProtKB: P092383   

Export aliases for MMP10 gene to outside databases

Previous GC identifers: GC11M104834 GC11M103998 GC11M102675 GC11M102178 GC11M102146 GC11M098569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP10 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and
fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MMP10 Gene:
MMP10 (matrix metallopeptidase 10 (stromelysin 2)) is a protein-coding gene. Diseases associated with MMP10 include epidermolysis bullosa dystrophica, and encephalomyelitis. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238
Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates
procollagenase

summary for MMP10 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP10 gene promoter:
         CREB   SRF   AP-1   deltaCREB   ATF-2   SRF (504 AA)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMP10 promoter sequence
   Search Chromatin IP Primers for MMP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22.3

MMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102641:  view genomic region     (about GC identifiers)

Start:
102,641,233 bp from pter      End:
102,651,359 bp from pter
Size:
10,127 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238 (See protein sequence)
Recommended Name: Stromelysin-2 precursor  
Size: 476 amino acids; 54151 Da
Cofactor: Binds 2 zinc ions per subunit
Cofactor: Calcium
3 PDB 3D structures from and Proteopedia for MMP10:
1Q3A (3D)        3V96 (3D)        4ILW (3D)    
Secondary accessions: B2R9X9 Q53HH9

Explore the universe of human proteins at neXtProt for MMP10: NX_P09238

Explore proteomics data for MMP10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP10 (P09238) (see all 12)
     HSLGLFH  GEADIMI  GIQSLYG  YRIVNYT 


    See MMP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002416.1  
    ENSEMBL proteins: 
     ENSP00000279441   ENSP00000441485  
    Reactome Protein details: P09238

    MMP10 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for MMP10 (MMP-10)
    Enzo Life Sciences proteins for MMP10
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MMP10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MMP10
    GenScript Custom Purified and Recombinant Proteins Services for MMP10
    Novus Biologicals MMP10 Proteins
    Novus Biologicals MMP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MMP10

     
    Search eBioscience for Proteins for MMP10 

     
    antibodies-online proteins for MMP10 (17 products) 

     
    antibodies-online peptides for MMP10

    MMP10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP10
    R&D Systems Antibodies for MMP10 (MMP-10)
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    Novus Biologicals MMP10 Antibodies
    Abcam antibodies for MMP10
    Cloud-Clone Corp. Antibodies for MMP10
    ThermoFisher Antibody for MMP10
    antibodies-online antibodies for MMP10 (97 products) 

    MMP10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP10
    R&D Systems ELISAs for MMP10 (MMP-10)         (see all)
    GenScript MMP10-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP10
    Cloud-Clone Corp. ELISAs for MMP10
    Cloud-Clone Corp. CLIAs for MMP10
    Search eBioscience for ELISAs for MMP10 
    antibodies-online kits for MMP10 (51 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP10
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS

    Graphical View of Domain Structure for InterPro Entry P09238

    ProtoNet protein and cluster: P09238

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP10_HUMAN, P09238
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    Find genes that share domains with MMP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP10_HUMAN, P09238
    Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates
    procollagenase
    Catalytic activity: Similar to stromelysin 1, but action on collagen types III, IV and V is weak

         Genatlas biochemistry entry for MMP10:
    matrix metalloproteinase 10,regulator in matrix remodeling in the MMP cluster,expressed in the developing bone

         Enzyme Numbers (IUBMB): EC 3.4.242 EC 3.4.24.221

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMP10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MMP10:
     Proliferating cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mmp10):
     cardiovascular system  immune system  normal  respiratory system 

    Find genes that share phenotypes with MMP10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MMP10: Mmp10tm1Jkmg Mmp10tm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for MMP10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP10:
    hsa-mir-26b-5p (MIRT028865)

    Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP10:
    hsa-miR-496
    SwitchGear 3'UTR luciferase reporter plasmidMMP10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP10
    Predesigned siRNA for gene silencing in human, mouse, rat MMP10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP10

    Clone
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    OriGene clones in human, mouse for MMP10 (see all 6)
    OriGene ORF clones in mouse, rat for MMP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MMP10 (NM_002425)
    Sino Biological Human cDNA Clone for MMP10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP10
    ESI BIO PureStem Progenitor for MMP10: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP10_HUMAN, P09238: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    endoplasmic reticulum2
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS2844164
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MMP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    4Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38
    5GPCR Pathway
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with MMP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP10
        Inhibition of Matrix Metalloproteinases
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    1 GeneGo (Thomson Reuters) Pathway for MMP10
        Cell adhesion ECM remodeling

    1 BioSystems Pathway for MMP10
        Matrix Metalloproteinases


    3 Reactome Pathways for MMP10
        Degradation of the extracellular matrix
    Collagen degradation
    Activation of Matrix Metalloproteinases


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP10: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MMP10 (P092383 ENSP000002794414) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAPLN1P109153, ENSP000002743414I2D: score=1 STRING: ENSP00000274341
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    BCANQ96GW73, ENSP000003312104I2D: score=2 STRING: ENSP00000331210
    MMP1ENSP000003227884STRING: ENSP00000322788
    MMP2ENSP000002190704STRING: ENSP00000219070
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS2844164
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030334regulation of cell migration IEA--
    GO:0030574collagen catabolic process TAS--

    Find genes that share ontologies with MMP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP10
      Browse compounds at ApexBio 

    Compounds for MMP10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    1 HMDB Compound for MMP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for MMP10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetantagonist10852638 10669951
    N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID-- --target--10592235

    7 Novoseek inferred chemical compound relationships for MMP10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 74.2 1 9578462 (1)
    matrigel 22.8 1 12379519 (1)
    12-o-tetradecanoylphorbol 13-acetate 9.97 1 8144618 (1)
    serine 8.4 6 15870107 (3), 19762781 (1), 16983356 (1), 17069010 (1)
    vegf 4.55 3 15868281 (1), 16980307 (1), 19220217 (1)
    oligonucleotide 0 2 8269280 (1), 9550265 (1)
    calcium 0 2 19769250 (1)



    Find genes that share compounds with MMP10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMP10 gene: 
    NM_002425.2  

    Unigene Cluster for MMP10:

    Matrix metallopeptidase 10 (stromelysin 2)
    Hs.2258  [show with all ESTs]
    Unigene Representative Sequence: NM_002425
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279441(uc001phg.2) ENST00000539681
    miRNA
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    Block miRNA regulation of human, mouse, rat MMP10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP10:
    hsa-miR-496
    SwitchGear 3'UTR luciferase reporter plasmidMMP10 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MMP10
      QuantiFast Probe-based Assays in human, mouse, rat MMP10

    Additional mRNA sequence: 

    AK222601.1 AK313960.1 BC002591.2 BT007442.1 X07820.1 

    5 DOTS entries:

    DT.106379  DT.120702938  DT.120702949  DT.99929471  DT.313463 

    Selected AceView cDNA sequences (see all 56):

    BP350564 BP350592 BP352531 AW949366 BP351427 BT007442 BP351309 BE740153 
    BP351724 BP351322 BP352568 BX281044 AI973162 BC002591 NM_002425 X07820 
    BP351604 BP352259 CF596568 CB528312 BP351299 BF034537 BM480245 BP351055 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MMP10 Expression
    About this image


    MMP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    MMP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP10: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MMP10
    OriGene qSTAR qPCR primer pairs in human, mouse for MMP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMP10
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    QuantiFast Probe-based Assays in human, mouse, rat MMP10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP10 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp101 , 5 matrix metallopeptidase 101, 5 80.35(n)1
    76.42(a)1
      9 (2.46 cM)5
    173841  NM_019471.21  NP_062344.11 
     75023605 
    chicken
    (Gallus gallus)
    Aves MMP101 matrix metallopeptidase 10 (stromelysin 2) 62.74(n)
    55.25(a)
      418981  NM_001278089.1  NP_001265018.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    51(a)
    49(a)
    many ↔ many
    many ↔ many
    3(192100483-192115896)
    3(192049389-192058962)


    ENSEMBL Gene Tree for MMP10 (if available)
    TreeFam Gene Tree for MMP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP10 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP272  MMP112  MMP172  MMP12  
    18 SIMAP similar genes for MMP10 using alignment to 2 protein entries:     MMP10_HUMAN (see all proteins):
    MMP3    MMP1    MMP13    MMP12    MMP27    MMP8
    MMP20    MMP7    MMP2    MMP26    MMP17    MMP14
    MMP11    MMP16    MMP19    MMP24    MMP25    MMP15

    Find genes that share paralogs with MMP10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP10 (see all 386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361394
    A breast cancer sample4--see VAR_0361392 E Q mis40--------
    rs1855118591,2
    --102640800(+) TGAGGC/GGGAGA 1 -- ds50010--------
    rs112254181,2
    C,F,A,H--102640805(+) GGGAGA/CTGAGA 1 -- ds500119Minor allele frequency- C:0.44NS EA NA WA 1416
    rs178610161,2
    C,F--102640838(-) GTGGGA/TTTCCT 1 -- ds50018Minor allele frequency- T:0.12NS NA CSA 312
    rs1888216151,2
    --102640882(+) TGGACA/TCCAAA 1 -- ds50010--------
    rs1930451121,2
    C--102640935(+) ATAATA/GTGCAG 1 -- ds50010--------
    rs178610151,2
    C--102640969(-) GAAATG/TGAACT 1 -- ds50011Minor allele frequency- T:0.01NS 180
    rs1484584191,2
    --102641024(+) TTACCC/TCTTTC 1 -- ds50010--------
    rs1152327361,2
    F--102641042(+) GGTGTG/ATAAGG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1438896871,2
    --102641061(+) CAATAA/TCTGTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MMP10 (102641233 - 102651359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MMP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv463CNV Insertion18451855

    Human Gene Mutation Database (HGMD): MMP10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP10
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185260    OMIM disorders: --

    11 diseases for MMP10:    
    About MalaCards
    epidermolysis bullosa dystrophica    encephalomyelitis    mast cell neoplasm    keratoconus
    richter's syndrome    vernal keratoconjunctivitis    merkel cell carcinoma    refractive error
    bladder transitional cell carcinoma    transitional cell carcinoma    arthritis

    2 diseases from the University of Copenhagen DISEASES database for MMP10:
    Lymphoma     Mast cell neoplasm

    Find genes that share disorders with MMP10           About GenesLikeMe

    24 Novoseek inferred disease relationships for MMP10 gene (see top 10)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    invasive cancer 48.3 1 19601983 (1)
    squamous cell cancer 47.3 2 19601983 (1)
    hnscc 43.4 1 16265652 (1)
    carcinoma squamous cell 42.6 7 12269770 (2), 17587817 (1), 14977049 (1), 11237387 (1)
    tumors 38.3 61 15833553 (5), 17695449 (4), 15720804 (3), 15356104 (2) (see all 20)
    metastasis 37 5 11487270 (1), 15557792 (1), 19921252 (1), 17695449 (1) (see all 5)
    keratoconus 37 1 11778801 (1)
    venous ulcer 34.3 3 11069614 (2), 8776359 (1)
    skin cancer 25.5 3 19601983 (1), 11237387 (1)
    carcinoma 24.1 7 1655673 (2), 7677979 (1), 1793490 (1), 11237387 (1)
    inflammation 23.5 1 19220217 (1)
    necrosis 22.1 3 19799791 (1), 8349617 (1), 11237387 (1)
    cancer 20.7 7 17054435 (2), 17207914 (1), 15564854 (1), 16331256 (1) (see all 6)
    nsclc 19 35 18427549 (6), 15720804 (4), 20032397 (3), 16506596 (3) (see all 5)
    atherosclerotic plaque 12 3 17059420 (1), 16580524 (1), 17981764 (1)
    cancer lung 8.32 11 14647437 (4), 15720804 (2), 17695449 (1), 18427549 (1)
    premalignant 7.69 1 11237387 (1)
    lung tumor 7.64 3 15720804 (1)
    cardiovascular diseases 0 2 17059420 (1), 19080965 (1)
    breast cancer 0 1 19243594 (1)
    arthritis 0 5 17009259 (4)
    adenocarcinoma 0 2 11487270 (1), 16506596 (1)
    atherosclerosis 0 4 17059420 (4)
    prostate cancer 0 1 15623660 (1)

    Genetic Association Database (GAD): MMP10
    Human Genome Epidemiology (HuGE) Navigator: MMP10 (12 documents)

    Export disorders for MMP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP10 gene, integrated from 10 sources (see all 206):
    (articles sorted by number of sources associating them with MMP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the catalytic domain of human matrix metalloproteinase 10. (PubMed id 15095982)1, 2, 9 Bertini I....Terni B. (J. Mol. Biol. 2004)
    2. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)1, 4, 9 Ogata T....Kuivaniemi H. (J. Vasc. Surg. 2005)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (Gut 2010)
    6. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. (PubMed id 18035073)1, 4 Hlatky M.A....Go A.S. (Am. Heart J. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The collagenase gene family in humans consists of at least four members. (PubMed id 2844164)1, 2 Muller D....Breathnach R. (Biochem. J. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4319 HGNC: 7156 AceView: MMP10 Ensembl:ENSG00000166670 euGenes: HUgn4319
    ECgene: MMP10 H-InvDB: MMP10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMP10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP10 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP10 gene:
    Search GeneIP for patents involving MMP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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