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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MMP1 Gene

protein-coding GIFtS: 74
GCID: GC11M102660

matrix metallopeptidase 1 (interstitial collagenase)

(Previous name: matrix metalloproteinase 1 (interstitial collagenase) )
(Previous symbol: CLG)

Explore 260 diseases affiliated with
MMP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix Metallopeptidase 1 (Interstitial Collagenase)¹ ²		Interstitial Collagenase²
CLG¹ ² ³ ⁵		Matrix Metalloprotease 1²
Fibroblast Collagenase² ³		Matrix Metalloproteinase 1²
EC 3.4.24.7³ ⁸		MMP-1³
Matrix Metalloproteinase 1 (Interstitial Collagenase)¹		Matrix Metalloproteinase-1³
CLGN²		EC 3.4.24⁸

External Ids:	HGNC: 7155¹	Entrez Gene: 4312²	Ensembl: ENSG00000196611⁷	OMIM: 120353⁵	UniProtKB: P03956³

Export aliases for MMP1 gene to outside databases

Previous GC identifers: GC11M104854 GC11M104017 GC11M102694 GC11M102198 GC11M102165 GC11M098588

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MMP1:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal

physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease

processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when

cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial

collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Alternative splicing results in multiple transcript variants.(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956

Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types

VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in

neuronal Tat's mediated neurotoxicity

summary for MMP1:

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent

endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a

wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been

identified in humans, which can be organized into six groups based on domain organization and substrate

preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and

-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others

(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:

alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell

proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs

has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.

Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor

to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the

basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves

or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP

expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all

have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result

in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MMP1 gene promoter:
CREB SRF AP-1 deltaCREB ATF-2 SRF (504 AA) c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MMP1 promoter sequence

Search SABiosciences Chromatin IP Primers for MMP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q21-q22

MMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M102660: view genomic region (about GC identifiers)

Start:	102,660,641 bp from pter	End:	102,668,966 bp from pter
Size:	8,326 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956 (See protein sequence)

Recommended Name: Interstitial collagenase precursor

Size: 469 amino acids; 54007 Da

Cofactor: Binds 4 calcium ions per subunit

Cofactor: Binds 2 zinc ions per subunit

Subunit: Interacts with HIV-1 Tat

Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)

6/15 PDB 3D structures from and Proteopedia for MMP1 (see all 15):

1AYK (3D)

1CGE (3D)

1CGF (3D)

1CGL (3D)

1HFC (3D)

1SU3 (3D)

Secondary accessions: P08156

Explore the universe of human proteins at neXtProt for MMP1: NX_P03956

Post-translational modifications:

Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of

the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P03956

4/16 DME Specific Peptides for MMP1 (P03956) (see all 16)

LTFDAIT

DNSPFDG

WSNVTPL

PRCGVPD

MMP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001139410.1 NP_002412.1

ENSEMBL proteins:

ENSP00000322788

Reactome Protein details: P03956
Human Recombinant Protein Products for MMP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MMP1 (MMP-1)
	Enzo Life Sciences proteins for MMP1
	OriGene Purified Protein: MMP1 OriGene Protein Over-expression Lysate: MMP1 OriGene Custom Protein Services for MMP1
	GenScript Custom Purified and Recombinant Proteins Services for MMP1
	Novus Biologicals MMP1 Proteins Novus Biologicals MMP1 Lysates
	Sino Biological Recombinant Protein for MMP1
	ProSpec Recombinant Protein for MMP1
	Uscn Proteins for MMP1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--

MMP1 for ontologies About GeneDecksing

MMP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP1
	R&D Systems Antibodies for MMP1 (MMP-1)
	OriGene Antibodies (see all 2): MMP1 OriGene Custom Antibody Services for MMP1
	GenScript Custom Superior Antibodies Services for MMP1
	Novus Biologicals MMP1 Antibodies
	Abcam antibodies for MMP1
	Uscn Antibodies for MMP1
	ThermoFisher Antibody for MMP1

Assay Products for MMP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MMP1 (MMP-1) (see first)
	R&D Systems ELISpot Kits & Development Modules for MMP1 (MMP-1)
	R&D Systems Multiplex/Array Assay Kits & Reagents for MMP1 (MMP-1)
	R&D Systems Kinase Activity Assays & Reagents for MMP1 (MMP-1)
	See all other biochemical assays at R&D Systems
	GenScript MMP1-Activity-based Protease Assay for Compound Screening
	Enzo Life Sciences assays for MMP1
	Uscn ELISAs and CLIAs for MMP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MMP1 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR024079 MetalloPept_cat_dom

IPR021158 Pept_M10A_Zn_BS

IPR021190 Pept_M10A_matrixin

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

Graphical View of Domain Structure for InterPro Entry P03956

ProtoNet protein and cluster: P03956

3 Blocks protein families:

IPB000585 Hemopexin repeat

IPB001818 Matrixin

IPB002477 Putative peptidoglycan binding domain 1

UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956

Domain: There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved

in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases)

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the

enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme

Similarity: Belongs to the peptidase M10A family

Similarity: Contains 4 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MMP1_HUMAN, P03956

Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types

VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in

neuronal Tat's mediated neurotoxicity

Catalytic activity: Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from

the N-terminus, at 775-Gly- -Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at

bonds where P1' is a hydrophobic residue

Enzyme regulation: Can be activated without removal of the activation peptide

Genatlas biochemistry entry for MMP1:

matrix metalloproteinase 1,regulator of matrix remodeling component of the MMP cluster,prognostic factor in case of

advanced gastric and ovarian cancers,activated by host/tumor cell interaction and mediating the invasive/metastatic

behavior of tumor cells through invasion of type I collagen,overexpressed in inflammatory bowel diseases

Enzyme Numbers (IUBMB): EC 3.4.24.7¹ ² EC 3.4.24²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IDA	9920899
GO:0005509	calcium ion binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MMP1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MMP1

miRNA Products:		miRTarBase miRNAs that target MMP1: hsa-mir-222 (MIRT000136)

		OriGene 3'-UTR Clone (see all 2): MMP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP1:
		hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: MMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP1 (see all 7) OriGene shRNA RFP: MMP1 OriGene siRNA: MMP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MMP1
			Sirion Biotech Customized adenovirus for overexpression of MMP1 Sirion Biotech Customized adenovirus for potent knockdown of MMP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MMP1 (NM_002421)
		Sino Biological Human cDNA Clone for MMP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MMP1
		LifeMap BioReagents: cell lines associated with MMP1: PureStem 4D20.8, NCr-fac Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor
		Sirion Biotech Customized stable knockdown cell line services for MMP1 Sirion Biotech Customized inducible knockdown cell line services for MMP1 Sirion Biotech Customized stable overexpressing cell line services for MMP1 Sirion Biotech Customized inducible overexpressing cell line services for MMP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Degradation of the extracellular matrix

	Degradation of the extracellular matrix	1.00			Activation of Matrix Metalloproteinases	0.40
	Degradation of collagen	0.79

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

	Immune response Oncostatin M signaling via MAPK in human cells	0.39			Oncostatin M Signaling Pathway	0.15
	Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Degradation of collagen

Degradation of collagen

1.00

Extracellular matrix organization

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for MMP1 (see all 6)

	Cell adhesion Cell-matrix glycoconjugates
	Immune response MIF-mediated glucocorticoid regulation
	Cell adhesion ECM remodeling
	Immune response Oncostatin M signaling via MAPK in human cells
	Metalloproteases in connective tissue degradation

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MMP1

	Inhibition of Matrix Metalloproteinases
	Colorectal Cancer Metastasis
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway
	Pancreatic Adenocarcinoma

5 GeneGo (Thomson Reuters) Pathways for MMP1

	Immune response MIF-mediated glucocorticoid regulation
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Immune response Oncostatin M signaling via MAPK in human cells

5/8 BioSystems Pathways for MMP1 (see all 8)

	Matrix Metalloproteinases
	Integrated Breast Cancer Pathway
	Oncostatin M Signaling Pathway
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Endothelins

5/12 Reactome Pathways for MMP1 (see all 12)

	Hemostasis
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Degradation of collagen
	Degradation of collagen
	Activation of Matrix Metalloproteinases

4 Kegg Pathways (Kegg details for MMP1):

	PPAR signaling pathway
	Pathways in cancer
	Bladder cancer
	Rheumatoid arthritis

MMP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MMP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for MMP1 (P03956³ ENSP00000322788⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BSG	P35613³, ENSP00000333769⁴	I2D: score=2 STRING: ENSP00000333769
ITGA2	P17301³, ENSP00000296585⁴	I2D: score=2 STRING: ENSP00000296585
CCL2	P13500³, ENSP00000225831⁴	I2D: score=1 STRING: ENSP00000225831
CCL7	P80098³, ENSP00000200307⁴	I2D: score=1 STRING: ENSP00000200307
MMP7	P09237³, ENSP00000260227⁴	I2D: score=1 STRING: ENSP00000260227

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0019048	virus-host interaction	IEA	--
GO:0022617	extracellular matrix disassembly	TAS	--
GO:0030198	extracellular matrix organization	TAS	--

MMP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MMP1 for compounds About GeneDecksing

EMD Millipore small molecules for MMP1:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for MMP1

Compounds for MMP1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Marimastat	Broad spectrum MMP inhibitor	[154039-60-8]
ONO 4817	Broad spectrum MMP inhibitor	[223472-31-9]
Ro 32-3555	Potent, collagenase-selective MMP inhibitor	[190648-49-8]
PD 166793	Broad spectrum MMP inhibitor	[199850-67-4]
Batimastat	Potent, broad spectrum MMP inhibitor	[130370-60-4]

2 HMDB Compounds for MMP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Zinc	Zinc (see all 2)	7440-66-6	--

6 DrugBank Compounds for MMP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Marimastat	--	154039-60-8	target	inhibitor	10852638 10669951 11752352
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID	--	--	target	--	10592235
N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE	--	--	target	--	10592235
N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE	--	--	target	--	10592235
N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE	--	--	target	--	10592235
[[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER	--	--	target	--	10592235

10/137 Novoseek chemical compound relationships for MMP1 gene (see all 137) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ilomastat	77	3	12729664 (1), 15754388 (1), 18984345 (1)
(4-aminophenyl)mercuric acetate	76.4	12	9063449 (1), 1480033 (1), 7896811 (1), 15711750 (1) (see all 5)
procollagen	67.6	58	18253916 (4), 19277961 (4), 17085293 (2), 15130753 (2) (see all 28)
hydroxamate	66.1	8	10353819 (2), 19239231 (1), 9484219 (1), 9548812 (1) (see all 6)
matrigel	65.3	14	10930227 (2), 12724357 (2), 11774278 (1), 14767528 (1) (see all 10)
cgs-27023a	65.1	2	19239231 (1), 16280020 (1)
batimastat	59.5	6	14679206 (2), 12372841 (1), 8997273 (1), 16483784 (1) (see all 5)
phxa 85	59.3	5	11462156 (4), 9418730 (1)
phosphocitrate	57.9	4	12825860 (2), 10395291 (1)
thps	56.1	3	10788434 (1), 11341845 (1), 12437092 (1)

Search CenterWatch for drugs/clinical trials and news about MMP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MMP1 gene (2 alternative transcripts):

NM_001145938.1 NM_002421.3

Unigene Cluster for MMP1:

Matrix metallopeptidase 1 (interstitial collagenase)

Hs.83169 [show with all ESTs]

Unigene Representative Sequence: NM_002421

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000315274(uc001phi.2 uc010ruv.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MMP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MMP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MMP1:
		hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: MMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMP1 (see all 7) OriGene shRNA RFP: MMP1 OriGene siRNA: MMP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MMP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MMP1 (NM_002421)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP1

Additional cDNA sequence:

AK024818.1 AK098450.1 AK130687.1 AK223034.1 AK223035.1 AK223036.1 AK223056.1 AK223281.1

AK225495.1 AK297723.1 AK301340.1 BC013118.1 BC013875.2 BT006874.1 BT020147.1 DQ399597.1

M13509.1 M15996.1 X05231.1 X54925.1

23 DOTS entries:

DT.118472 DT.95134854 DT.100771605 DT.120702915 DT.95160513 DT.95160516 DT.120702914 DT.95160514

DT.120702985 DT.120702928 DT.120702980 DT.120702944 DT.120702911 DT.120702955 DT.100771604 DT.120702975

DT.120702908 DT.120702927 DT.120702961 DT.120702964 DT.120702984 DT.120702990 DT.120702995

24/375 AceView cDNA sequences (see all 375):

BQ688686 BP344850 AA514656 BP345060 BP344207 BP345274 BP364853 BP364152

BP345398 BP365504 BP352990 BP337087 BX280887 BP346114 AU139996 BP345324

AW963590 AU135868 BP344861 BP337151 AW449628 BP344446 BP363297 AA132297

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGTCACT

About this image

MMP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Wharton's Jelly

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Human umbilical vein endothelial cells (HUVEC) (Primary Cell)

Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

See MMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMP1

SOURCE GeneReport for Unigene cluster: Hs.83169

SABiosciences Expression via Pathway-Focused PCR Arrays including MMP1 (see all 6):

Lung Cancer in human mouse rat

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Endothelial Cell Biology in human mouse rat

Atherosclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MMP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MMP1¹	matrix metallopeptidase 1 (interstitial collagenase)	66.37(n) 59.96(a)		418982 XM_417176.2 XP_417176.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	53(a) 47(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	3(192130497-192142327) 3(192236788-192239847)
African clawed frog (Xenopus laevis)	Amphibia	mmp1-prov²	matrix metalloproteinase 1 (interstitial collagenase)	78.91(n)		BC054233.1
zebrafish (Danio rerio)	Actinopterygii	mmp13a⁶ mmp16a⁶	matrix metallopeptidase 16a (membrane-inserted)	42(a) 21(a)	1 ↔ many possible ortholog	10(39959934-39979810) 24(32795678-32875906)
worm (Caenorhabditis elegans)	Secernentea	C31B8.8³	--	44(a)		V(2905685-2909407) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G45040⁶ AT1G59970⁶ (see all 5)	matrix metalloprotease domain-containing protein (see all 5)	26(a) 25(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(18577650-18578914) 1(22073534-22074876)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	matrixin family protein metalloendoproteinase 1 precursor, putative, expre... (see all 4)	8(a) 26(a) (see all 4)	many ↔ many many ↔ many (see all 4)	10(21890877-21896676) 6(7223943-7225418)

ENSEMBL Gene Tree for MMP1 (if available)
TreeFam Gene Tree for MMP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MMP1 gene

MMP13² MMP20² MMP8² MMP14² MMP9² MMP16² MMP2² MMP25²

MMP24² MMP15² MMP11² MMP3² MMP27² MMP17² MMP10²

18/19 SIMAP similar genes for MMP1 using alignment to 4 protein entries: MMP1_HUMAN (see all proteins) (see all similar genes):

MMP8 MMP3 MMP10 MMP13 MMP27 MMP20

MMP7 MMP12 MMP2 MMP23B MMP11 MMP26

MMP17 MMP14 MMP16 MMP24 MMP25 MMP19

MMP1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MMP1
PGOHUM00000258575

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17293823^1,2	C,F,H	--	98588382(+)	`TCACTG/AATTTT`	2	--	ds500¹		23	NA NS EA	2070
rs17880681^1,2	C	--	98588513(-)	`GTGGGA/GAATGA`	2	--	ds500¹		1	NS	178
rs17883091^1,2	C	--	98588728(-)	`ACACAT/CGTGCA`	2	--	ut3¹ ese³		1	NS	180
rs5031038^1,2	C,F	--	98588977(-)	`TTTGCA/GTATTT`	2	--	ut3¹ ese³		9	MN NA	552
rs17880115^1,2	C,F,H	--	98588994(-)	`TCTTAT/CTTATA`	2	--	ut3¹		7	NS NA	972
rs111469912^1,2	F	--	98589330(+)	`TTTTGG/ACATTT`	2	--	int¹		1	CSA	4
rs17879960^1,2	C,F	--	98589346(-)	`TGTTAG/ATTGGA`	2	--	int¹		8	NS NA	884
rs111822238^1,2		--	98589627(+)	`AGATCG/ATTTGT`	2	--	int¹		1	CSA	2
rs17880516^1,2	C	--	98589683(-)	`TTAAAG/CGCCTT`	2	--	int¹		2	NS WA	296
rs17883075^1,2	C	--	98589816(-)	`GATGTA/GGAATT`	2	--	int¹		2	NS EA	298

HapMap Linkage Disequilibrium report for MMP1 (102660641 - 102668966 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMP1: --
Human Gene Mutation Database (HGMD): MMP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMP1

DNA2.0 Custom Variant and Variant Library Synthesis for MMP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MMP1 for disorders           About GeneDecksing

OMIM gene information: 120353
OMIM disorders: 606963  226600
20/260 diseases for MMP1 (see all 260):    About MalaCards

epidermolysis bullosa dystrophica, autosomal recessive, modifier of epidermolysis bullosa dystrophica epidermolysis bullosa copd, rate of decline of lung function in

open-angle glaucoma arthritis recessive dystrophic epidermolysis bullosa superior limbic keratoconjunctivitis

alpha 1-antitrypsin deficiency epidermolysis bullosa pruriginosa pigmented villonodular synovitis xeroderma pigmentosum, group c

encephalomyelitis villonodular synovitis middle ear cholesteatoma mitral valve prolapse

oral submucous fibrosis primary open angle glaucoma lichen planus cleft lip/palate

6 diseases from the University of Copenhagen DISEASES database for MMP1:

Arthritis Periodontal disease Heart disease Carcinoma

Atherosclerosis Breast cancer

10/96 Novoseek disease relationships for MMP1 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	72.4	37	11908571 (2), 9512498 (2), 15743480 (2), 16688934 (2) (see all 24)
rheumatoid arthritis	68.3	83	12447637 (3), 15292813 (2), 8849537 (2), 12509618 (2) (see all 58)
metastasis	63.1	161	18360703 (5), 19608765 (4), 10794801 (4), 9649139 (4) (see all 83)
tumors	61.3	375	18360703 (5), 12218298 (5), 16267613 (4), 17663001 (4) (see all 99)
gingival overgrowth	60.5	12	18261580 (2), 17956473 (2), 15183848 (1), 16670920 (1) (see all 7)
necrosis	58.9	104	18627438 (3), 17990358 (2), 19661147 (2), 16488289 (2) (see all 84)
atherosclerotic plaque	56.6	44	8774133 (4), 15073384 (4), 15621056 (3), 11866921 (2) (see all 23)
arthritis	54.4	32	12010565 (3), 10334680 (2), 11665967 (2), 12447637 (2) (see all 20)
inflammation	53.5	44	19160981 (2), 11240267 (1), 11084020 (1), 12928151 (1) (see all 35)
chronic periodontitis	53.5	18	15257748 (4), 12622858 (3), 19758971 (2), 18710412 (2) (see all 9)

Genetic Association Database (GAD): MMP1
Human Genome Epidemiology (HuGE) Navigator: MMP1 (224 documents)

Export disorders for MMP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MMP1 gene, integrated from 9 sources (see all 2318):
(articles sorted by number of sources associating them with MMP1)

Utopia: connect your pdf to the dynamic
world of online information

Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer. (PubMed id 12969782)^{1, 4, 9} Wenham R.M....Berchuck A. (2003)
Lack of association of a functionally relevant single nucleotide polymorphism of matrix metalloproteinase-1 promoter with systemic sclerosis (scleroderma). (PubMed id 11528521)^{1, 4, 9} Johnson R.W....Tan F.K. (2001)
The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China. (PubMed id 15879464)^{1, 4, 9} Shan K....Yan L. (2005)
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease. (PubMed id 15955221)^{1, 4, 9} Okamoto K....Yuasa I. (2005)
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer] (PubMed id 16080875)^{1, 4, 9} Li Y....Fang S.M. (2005)
Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population. (PubMed id 15257748)^{1, 4, 9} Holla L.I....Vacha J. (2004)
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma. (PubMed id 15319295)^{1, 4, 9} Hirata H....Hinoda Y. (2004)
Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma. (PubMed id 15274394)^{1, 4, 9} Zinzindohoue F....Laurent-Puig P. (2004)
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. (PubMed id 15312099)^{1, 4, 9} Itagaki M....Yamazaki K. (2004)
Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis. (PubMed id 15142265)^{1, 4, 9} Dorr S....Keyszer G. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4312	HGNC: 7155	AceView: MMP1	Ensembl:ENSG00000196611	euGenes: HUgn4312
ECgene: MMP1	Kegg: 4312	H-InvDB: MMP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MMP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MMP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mmp1/
Wikipedia	http://en.wikipedia.org/wiki/Collagenase

Intellectual Property for MMP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MMP1 gene:
Search GeneIP for patents involving MMP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore small molecules (inhibitor) for MMP1
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MMP1 Proteins, Antibodies, CLIAs, and ELISAs

Cell Lines associated with MMP1: PureStem 4D20.8, NCr-fac Progenitor,
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MMP1 Gene

matrix metallopeptidase 1 (interstitial collagenase)

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Leg Ulcer
Gingivitis
Osteoarthritis Knee
Pulmonary Emphysema
Scars Hypertrophic
Aortic Aneurysm Thoracic
Endometriosis
Carcinoma Basal Cell
Pulpitis
Colitis Ulcerative
aggressiveness
Oral Submucous Fibrosis
LUNG CARCINOMA
FIBROMATOSIS, GINGIVAL, HEREDITARY
Atherosclerosis
Lymphatic Metastasis
Skin Diseases
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Scar
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Hepatitis C Chronic
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stromal tumors
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MMP1 Gene

matrix metallopeptidase 1 (interstitial collagenase)

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