Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MMP1 Gene

Aliases for MMP1 Gene

  • Matrix Metallopeptidase 1 2 3
  • CLG 3 4 6
  • Interstitial Collagenase 2 3
  • Fibroblast Collagenase 3 4
  • EC 3.4.24.7 4 63
  • Matrix Metalloproteinase 1 (Interstitial Collagenase) 2
  • Matrix Metallopeptidase 1 (Interstitial Collagenase) 3
  • Matrix Metalloproteinase 1 3
  • Matrix Metalloproteinase-1 4
  • Matrix Metalloprotease 1 3
  • EC 3.4.24 63
  • MMP-1 4
  • CLGN 3

External Ids for MMP1 Gene

Previous HGNC Symbols for MMP1 Gene

  • CLG

Previous GeneCards Identifiers for MMP1 Gene

  • GC11M104854
  • GC11M104017
  • GC11M102694
  • GC11M102198
  • GC11M102165
  • GC11M102660
  • GC11M098588

Summaries for MMP1 Gene

Entrez Gene Summary for MMP1 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GeneCards Summary for MMP1 Gene

MMP1 (Matrix Metallopeptidase 1) is a Protein Coding gene. Diseases associated with MMP1 include pulmonary disease, chronic obstructive and epidermolysis bullosa dystrophica, ar. Among its related pathways are Pathways in cancer and GPCR Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP1 Gene

  • Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tats mediated neurotoxicity.

Tocris Summary for MMP1 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP1 Gene

Genomics for MMP1 Gene

Regulatory Elements for MMP1 Gene

Genomic Location for MMP1 Gene

Start:
102,789,910 bp from pter
End:
102,798,235 bp from pter
Size:
8,326 bases
Orientation:
Minus strand

Genomic View for MMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP1 Gene

Proteins for MMP1 Gene

  • Protein details for MMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03956-MMP1_HUMAN
    Recommended name:
    Interstitial collagenase
    Protein Accession:
    P03956
    Secondary Accessions:
    • P08156

    Protein attributes for MMP1 Gene

    Size:
    469 amino acids
    Molecular mass:
    54007 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for MMP1 Gene

neXtProt entry for MMP1 Gene

Proteomics data for MMP1 Gene at MOPED

Post-translational modifications for MMP1 Gene

  • Tyrosine phosphorylated in platelets by PKDCC/VLK.
  • Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MMP1 Gene

Gene Families for MMP1 Gene

Suggested Antigen Peptide Sequences for MMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P03956

UniProtKB/Swiss-Prot:

MMP1_HUMAN :
  • P03956
Domain:
  • There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases)
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP1: view

Function for MMP1 Gene

Molecular function for MMP1 Gene

GENATLAS Biochemistry: matrix metalloproteinase 1,regulator of matrix remodeling component of the MMP cluster,prognostic factor in case of advanced gastric and ovarian cancers,activated by host/tumor cell interaction and mediating the invasive/metastatic behavior of tumor cells through invasion of type I collagen,overexpressed in inflammatory bowel diseases
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly- -Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1 is a hydrophobic residue
UniProtKB/Swiss-Prot EnzymeRegulation: Can be activated without removal of the activation peptide
UniProtKB/Swiss-Prot Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tats mediated neurotoxicity.

Enzyme Numbers (IUBMB) for MMP1 Gene

Gene Ontology (GO) - Molecular Function for MMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 19022250
GO:0004222 metalloendopeptidase activity IDA 9920899
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP1: view

Phenotypes for MMP1 Gene

genes like me logo Genes that share phenotypes with MMP1: view

Animal Models for MMP1 Gene

MGI Knock Outs for MMP1:

miRNA for MMP1 Gene

miRTarBase miRNAs that target MMP1

No data available for Transcription Factor Targeting and HOMER Transcription for MMP1 Gene

Localization for MMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP1 Gene COMPARTMENTS Subcellular localization image for MMP1 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP1: view

Pathways for MMP1 Gene

genes like me logo Genes that share pathways with MMP1: view

Gene Ontology (GO) - Biological Process for MMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 15863497
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with MMP1: view

Compounds for MMP1 Gene

(15) ApexBio Compounds for MMP1 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2. [704888-90-4]
ARP 101 Selective inhibitor of MMP-2. [849773-63-3]
Batimastat (BB-94) potent and synthetic inhibitor of a broad spectrum of MMPs [130370-60-4]
CL 82198 hydrochloride Selective inhibitor of MMP-13. [307002-71-7]
CP 471474 Broad spectrum MMP inhibitor. [210755-45-6]
CTS-1027 potent small molecule inhibitor of MMPs. [193022-04-7]
GM 6001 Broad-spectrum MMP inhibitor. [142880-36-2]
Marimastat Broad spectrum inhibitor of MMPs. [154039-60-8]
NSC 405020 novel small molecule inhibitor of MT1-MMP [7497-7-6]
ONO 4817 Broad spectrum MMP inhibitor. [223472-31-9]
PD 166793 Broad spectrum MMP inhibitor. [199850-67-4]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor. [190648-49-8]
UK 356618 Potent and selective inhibitor of MMP-3. [230961-08-7]
UK 370106 Highly selective MMP-3 and MMP-12 inhibitor. [230961-21-4]
WAY 170523 Potent and selective inhibitor of MMP-13. [307002-73-9]

(5) Tocris Compounds for MMP1 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(2) HMDB Compounds for MMP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Zinc
  • Zinc
7440-66-6

(137) Novoseek inferred chemical compound relationships for MMP1 Gene

Compound -log(P) Hits PubMed IDs
ilomastat 77 3
(4-aminophenyl)mercuric acetate 76.4 5
procollagen 67.6 40
hydroxamate 66.1 7
matrigel 65.3 12
genes like me logo Genes that share compounds with MMP1: view

Transcripts for MMP1 Gene

mRNA/cDNA for MMP1 Gene

Unigene Clusters for MMP1 Gene

Matrix metallopeptidase 1 (interstitial collagenase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP1 Gene

No ASD Table

Relevant External Links for MMP1 Gene

GeneLoc Exon Structure for
MMP1
ECgene alternative splicing isoforms for
MMP1

Expression for MMP1 Gene

mRNA expression in normal human tissues for MMP1 Gene

mRNA differential expression in normal tissues according to GTEx for MMP1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP1 Gene

SOURCE GeneReport for Unigene cluster for MMP1 Gene Hs.83169

genes like me logo Genes that share expressions with MMP1: view

No data available for mRNA Expression by UniProt/SwissProt for MMP1 Gene

Orthologs for MMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP1 35
  • 99.5 (n)
  • 99.36 (a)
MMP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100848085 35
  • 86.36 (n)
  • 86 (a)
MMP1 36
  • 85 (a)
OneToMany
MMP1 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC489428 35
  • 85.09 (n)
  • 82.02 (a)
MMP1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp1a 35
  • 71.54 (n)
  • 59.65 (a)
Mmp1a 16
Mmp1a 36
  • 59 (a)
OneToMany
Mmp1b 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MMP1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp1 35
  • 70.45 (n)
  • 58.35 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
MMP1 35
  • 66.3 (n)
  • 59.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia mmp1-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7607 35
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 44 (a)
Species with no ortholog for MMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP1 Gene

ENSEMBL:
Gene Tree for MMP1 (if available)
TreeFam:
Gene Tree for MMP1 (if available)

Paralogs for MMP1 Gene

Selected SIMAP similar genes for MMP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MMP1 Gene

genes like me logo Genes that share paralogs with MMP1: view

Variants for MMP1 Gene

Sequence variations from dbSNP and Humsavar for MMP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_011969 -
VAR_011970 -
VAR_021024 -
VAR_021025 -
VAR_021026 -

Relevant External Links for MMP1 Gene

HapMap Linkage Disequilibrium report
MMP1
Human Gene Mutation Database (HGMD)
MMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP1 Gene

Disorders for MMP1 Gene

(2) OMIM Diseases for MMP1 Gene (120353)

(96) Novoseek inferred disease relationships for MMP1 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 72.4 28
rheumatoid arthritis 68.3 70
metastasis 63.1 120
tumors 61.3 154
gingival overgrowth 60.5 9

Relevant External Links for MMP1

Genetic Association Database (GAD)
MMP1
Human Genome Epidemiology (HuGE) Navigator
MMP1
genes like me logo Genes that share disorders with MMP1: view

No data available for UniProtKB/Swiss-Prot for MMP1 Gene

Publications for MMP1 Gene

  1. 1.56-A structure of mature truncated human fibroblast collagenase. (PMID: 8090713) Spurlino J.C. … Et A.L. (Proteins 1994) 3 4 23
  2. High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR. (PMID: 9484219) Moy F.J. … Powers R. (Biochemistry 1998) 3 4 23
  3. Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. (PMID: 11489811) Ghilardi G. … Scorza R. (Clin. Cancer Res. 2001) 3 23 48
  4. Lack of an association of a single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene in Czech women with pregnancy-induced hypertension. (PMID: 11586041) Jurajda M. … VA!cha J. (Gynecol. Obstet. Invest. 2001) 3 23 48
  5. Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study. (PMID: 11824952) Constantin A. … Cantagrel A. (J. Rheumatol. 2002) 3 23 48

Products for MMP1 Gene

Sources for MMP1 Gene

Back to Top

Content