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MMP1 Gene

protein-coding   GIFtS: 73
GCID: GC11M102660

Matrix Metallopeptidase 1 (Interstitial Collagenase)

(Previous name: matrix metalloproteinase 1 (interstitial collagenase))
(Previous symbol: CLG)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Metallopeptidase 1 (Interstitial Collagenase)1 2     Interstitial Collagenase2
CLG1 2 3 5     Matrix Metalloprotease 12
Fibroblast Collagenase2 3     Matrix Metalloproteinase 12
EC 3.4.24.73 8     MMP-13
Matrix Metalloproteinase 1 (Interstitial Collagenase)1     Matrix Metalloproteinase-13
CLGN2     EC 3.4.248

External Ids:    HGNC: 71551   Entrez Gene: 43122   Ensembl: ENSG000001966117   OMIM: 1203535   UniProtKB: P039563   

Export aliases for MMP1 gene to outside databases

Previous GC identifers: GC11M104854 GC11M104017 GC11M102694 GC11M102198 GC11M102165 GC11M098588


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMP1 Gene:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in
normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in
disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are
activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the
interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to
chromosome 11q22.3. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Mar 2009)

GeneCards Summary for MMP1 Gene:
MMP1 (matrix metallopeptidase 1 (interstitial collagenase)) is a protein-coding gene. Diseases associated with MMP1 include epidermolysis bullosa dystrophica, autosomal recessive, modifier of, and copd, rate of decline of lung function in. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956
Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of
types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a
decrease in neuronal Tat's mediated neurotoxicity

summary for MMP1 Gene:
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent
endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a
wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been
identified in humans, which can be organized into six groups based on domain organization and substrate
preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and
-11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others
(MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors:
alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell
proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs
has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer.
Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor
to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the
basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves
or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP
expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all
have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result
in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMP1 gene promoter:
         CREB   SRF   AP-1   deltaCREB   ATF-2   SRF (504 AA)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MMP1 promoter sequence
   Search Chromatin IP Primers for MMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q21-q22

MMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102660:  view genomic region     (about GC identifiers)

Start:
102,660,641 bp from pter      End:
102,668,966 bp from pter
Size:
8,326 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956 (See protein sequence)
Recommended Name: Interstitial collagenase precursor  
Size: 469 amino acids; 54007 Da
Cofactor: Binds 4 calcium ions per subunit
Cofactor: Binds 2 zinc ions per subunit
Subunit: Interacts with HIV-1 Tat
Selected PDB 3D structures from and Proteopedia for MMP1 (see all 15):
1AYK (3D)        1CGE (3D)        1CGF (3D)        1CGL (3D)        1HFC (3D)        1SU3 (3D)    
Secondary accessions: P08156

Explore the universe of human proteins at neXtProt for MMP1: NX_P03956

Explore proteomics data for MMP1 at MOPED

Post-translational modifications: 

  • Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated
    form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for
    collagenase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMP1 (P03956) (see all 16)
     LTFDAIT  DNSPFDG  WSNVTPL  PRCGVPD 


    See MMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139410.1  NP_002412.1  

    ENSEMBL proteins: 
     ENSP00000322788  
    Reactome Protein details: P03956

    MMP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MMP1 (MMP-1)
    Enzo Life Sciences proteins for MMP1
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    OriGene Protein Over-expression Lysate for MMP1
    OriGene MassSpec for MMP1
    OriGene Custom Protein Services for MMP1
    GenScript Custom Purified and Recombinant Proteins Services for MMP1
    Novus Biologicals MMP1 Proteins
    Novus Biologicals MMP1 Lysates
    Sino Biological Recombinant Protein for MMP1
    Sino Biological Cell Lysate for MMP1
    ProSpec Recombinant Protein for MMP1
    Cloud-Clone Corp. Proteins for MMP1

    MMP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MMP1
    R&D Systems Antibodies for MMP1 (MMP-1)
    OriGene Antibodies for MMP1
    OriGene Custom Antibody Services for MMP1
    Novus Biologicals MMP1 Antibodies
    Abcam antibodies for MMP1
    Cloud-Clone Corp. Antibodies for MMP1
    ThermoFisher Antibody for MMP1
    LSBio Antibodies in human, mouse, rat for MMP1

    MMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMP1
    R&D Systems ELISAs for MMP1 (MMP-1)         (see all)
    GenScript MMP1-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for MMP1
    Cloud-Clone Corp. ELISAs for MMP1
    Cloud-Clone Corp. CLIAs for MMP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    IUPHAR Guide to PHARMACOLOGY protein family classification: MMP1
    Cell-surface protein and extracellular matrix metalloproteinases

    Selected InterPro protein domains (see all 11):
     IPR024079 MetalloPept_cat_dom
     IPR021158 Pept_M10A_Zn_BS
     IPR021190 Pept_M10A
     IPR000585 Hemopexin-like_dom
     IPR028709 MMP1/MMP8

    Graphical View of Domain Structure for InterPro Entry P03956

    ProtoNet protein and cluster: P03956

    3 Blocks protein domains:
    IPB000585 Hemopexin repeat
    IPB001818 Matrixin
    IPB002477 Putative peptidoglycan binding domain 1


    UniProtKB/Swiss-Prot: MMP1_HUMAN, P03956
    Domain: There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is
    involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases)
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Similarity: Belongs to the peptidase M10A family
    Similarity: Contains 4 hemopexin repeats


    MMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMP1_HUMAN, P03956
    Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of
    types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a
    decrease in neuronal Tat's mediated neurotoxicity
    Catalytic activity: Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule
    from the N-terminus, at 775-Gly- -Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and
    alpha-macroglobulins at bonds where P1' is a hydrophobic residue
    Enzyme regulation: Can be activated without removal of the activation peptide

         Genatlas biochemistry entry for MMP1:
    matrix metalloproteinase 1,regulator of matrix remodeling component of the MMP cluster,prognostic factor in case
    of advanced gastric and ovarian cancers,activated by host/tumor cell interaction and mediating the
    invasive/metastatic behavior of tumor cells through invasion of type I collagen,overexpressed in inflammatory
    bowel diseases

         Enzyme Numbers (IUBMB): EC 3.4.24.71 2 EC 3.4.242

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IDA9920899
    GO:0005509calcium ion binding IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    MMP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mmp1a):
     homeostasis/metabolism  immune system  tumorigenesis 

    MMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmp1atm1Otin for MMP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMP1:
    hsa-mir-145-5p (MIRT021518), hsa-mir-222-3p (MIRT000136)

    Block miRNA regulation of human, mouse, rat MMP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP1:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidMMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMP1
    Predesigned siRNA for gene silencing in human, mouse, rat MMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMP1

    Clone
    Products:
         
    OriGene clones in human, mouse for MMP1 (see all 12)
    OriGene ORF clones in mouse, rat for MMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MMP1 (NM_002421)
    Sino Biological Human cDNA Clone for MMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MMP1
    ESI BIO PureStem Progenitors for MMP1: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMP1_HUMAN, P03956: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    MMP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMP1 About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Integrin Pathway
    UPA-UPAR Pathway0.56
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MMP1
        Inhibition of Matrix Metalloproteinases
    Colorectal Cancer Metastasis
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway
    Pancreatic Adenocarcinoma

    5 GeneGo (Thomson Reuters) Pathways for MMP1
        Immune response MIF-mediated glucocorticoid regulation
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response Oncostatin M signaling via MAPK in human cells

    Selected BioSystems Pathways for MMP1 (see all 9)
        Matrix Metalloproteinases
    Integrated Breast Cancer Pathway
    Oncostatin M Signaling Pathway
    Prostate Cancer
    Endothelins


    5 Reactome Pathways for MMP1
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Degradation of the extracellular matrix
    Basigin interactions
    Collagen degradation
    Activation of Matrix Metalloproteinases


    4 Kegg Pathways  (Kegg details for MMP1):
        PPAR signaling pathway
    Pathways in cancer
    Bladder cancer
    Rheumatoid arthritis


    MMP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP1 (see all 6): 
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MMP1 (P039563 ENSP000003227884) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSGP356133, ENSP000003337694I2D: score=2 STRING: ENSP00000333769
    ITGA2P173013, ENSP000002965854I2D: score=2 STRING: ENSP00000296585
    CCL2P135003, ENSP000002258314I2D: score=1 STRING: ENSP00000225831
    CCL7P800983, ENSP000002003074I2D: score=1 STRING: ENSP00000200307
    MMP7P092373, ENSP000002602274I2D: score=1 STRING: ENSP00000260227
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS2167156
    GO:0007596blood coagulation TAS--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0022617extracellular matrix disassembly TAS--

    MMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MMP1
    Selected ApexBio Compounds for MMP1 (see all 15)     About this table
    CompoundAction CAS #
    ARP 100Selective inhibitor of MMP-2[704888-90-4]
    ARP 101Selective inhibitor of MMP-2[849773-63-3]
    Batimastat (BB-94)potent and synthetic inhibitor of a broad spectrum of MMPs[130370-60-4]
    CL 82198 hydrochlorideSelective inhibitor of MMP-13[307002-71-7]
    CP 471474Broad spectrum MMP inhibitor[210755-45-6]
    CTS-1027potent small molecule inhibitor of MMPs[193022-04-7]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    MarimastatBroad spectrum inhibitor of MMPs[154039-60-8]
    NSC 405020novel small molecule inhibitor of MT1-MMP[7497-7-6]
    ONO 4817Broad spectrum MMP inhibitor[223472-31-9]

    Compounds for MMP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]
    MarimastatBroad spectrum MMP inhibitor[154039-60-8]
    GM 6001Broad-spectrum MMP inhibitor[142880-36-2]
    UK 383367Potent and selective BMP-1 (PCP) inhibitor[348622-88-8]
    Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]

    2 HMDB Compounds for MMP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ZincZinc (see all 2)7440-66-6--

    6 DrugBank Compounds for MMP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Marimastat-- 154039-60-8targetinhibitor10852638 10669951 11752352
    METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID-- --target--10592235
    N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE-- --target--10592235
    N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE-- --target--10592235
    N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE-- --target--10592235
    [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MMP1 gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ilomastat 77 3 12729664 (1), 15754388 (1), 18984345 (1)
    (4-aminophenyl)mercuric acetate 76.4 12 9063449 (1), 1480033 (1), 7896811 (1), 15711750 (1) (see all 5)
    procollagen 67.6 58 18253916 (4), 19277961 (4), 17085293 (2), 15130753 (2) (see all 28)
    hydroxamate 66.1 8 10353819 (2), 19239231 (1), 9484219 (1), 9548812 (1) (see all 6)
    matrigel 65.3 14 10930227 (2), 12724357 (2), 11774278 (1), 14767528 (1) (see all 10)
    cgs-27023a 65.1 2 19239231 (1), 16280020 (1)
    batimastat 59.5 6 14679206 (2), 12372841 (1), 8997273 (1), 16483784 (1) (see all 5)
    phxa 85 59.3 5 11462156 (4), 9418730 (1)
    phosphocitrate 57.9 4 12825860 (2), 10395291 (1)
    thps 56.1 3 10788434 (1), 11341845 (1), 12437092 (1)



    MMP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMP1 gene (2 alternative transcripts): 
    NM_001145938.1  NM_002421.3  

    Unigene Cluster for MMP1:

    Matrix metallopeptidase 1 (interstitial collagenase)
    Hs.83169  [show with all ESTs]
    Unigene Representative Sequence: NM_002421
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315274(uc001phi.2 uc010ruv.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat MMP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MMP1:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidMMP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MMP1
    Predesigned siRNA for gene silencing in human, mouse, rat MMP1
    Clone
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    OriGene clones in human, mouse for MMP1 (see all 12)
    OriGene ORF clones in mouse, rat for MMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MMP1 (NM_002421)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMP1
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      QuantiFast Probe-based Assays in human, mouse, rat MMP1

    Additional mRNA sequence: 

    AK024818.1 AK098450.1 AK130687.1 AK223034.1 AK223035.1 AK223036.1 AK223056.1 AK223281.1 
    AK225495.1 AK297723.1 AK301340.1 BC013118.1 BC013875.2 BT006874.1 BT020147.1 DQ399597.1 
    M13509.1 M15996.1 X05231.1 X54925.1 

    23 DOTS entries:

    DT.118472  DT.95134854  DT.100771605  DT.120702915  DT.95160513  DT.95160516  DT.120702914  DT.95160514 
    DT.120702985  DT.120702928  DT.120702980  DT.120702944  DT.120702911  DT.120702955  DT.100771604  DT.120702975 
    DT.120702908  DT.120702927  DT.120702961  DT.120702964  DT.120702984  DT.120702990  DT.120702995 

    Selected AceView cDNA sequences (see all 375):

    BP352990 BP364163 AU135868 BP337087 BP344446 AA308204 BP345060 AK098450 
    BP364853 BP344861 AA132297 BP345274 BP363297 CF128897 AA386155 BP344207 
    AW963590 BP365838 AA081283 BP364152 BP366300 CA454855 AW449628 BQ688686 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MMP1 expression in normal human tissues (normalized intensities)      MMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGTCACT
    MMP1 Expression
    About this image


    MMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Wharton's Jelly
             Placenta-derived mesenchymal stem cells (family)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Wharton's jelly-derived stem cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Smooth Muscle (Muscoskeletal System)
             Synthetic vascular smooth muscle-like cells
    MMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83169
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MMP1 (see all 6): 
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MMP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmp1a1 , 5 matrix metallopeptidase 1a (interstitial collagenase)1, 5 71.54(n)1
    59.65(a)1
      9 (2.46 cM)5
    839951  NM_032006.31  NP_114395.11 
     74641415 
    chicken
    (Gallus gallus)
    Aves MMP11 matrix metallopeptidase 1 (interstitial collagenase) 66.3(n)
    59.73(a)
      418982  XM_417176.3  XP_417176.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    1 → many
    3(192130497-192142327)
    African clawed frog
    (Xenopus laevis)
    Amphibia mmp1-prov2 matrix metalloproteinase 1 (interstitial collagenase) 78.91(n)    BC054233.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.76072 Oncorhynchus mykiss mmp mRNA for matrix metalloproteinase, more 71.8(n)    AB043536.1 


    ENSEMBL Gene Tree for MMP1 (if available)
    TreeFam Gene Tree for MMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMP1 gene
    MMP202  MMP132  MMP82  MMP142  MMP252  MMP162  MMP72  MMP242  
    MMP152  MMP32  MMP112  MMP272  MMP172  MMP102  
    17 SIMAP similar genes for MMP1 using alignment to 4 protein entries:     MMP1_HUMAN (see all proteins):
    MMP8    MMP3    MMP10    MMP13    MMP27    MMP20
    MMP7    MMP12    MMP2    MMP23B    MMP11    MMP26
    MMP17    MMP14    MMP16    MMP24    MMP25

    MMP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MMP1
    PGOHUM00000258575


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMP1 (see all 349)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005379121,2
    C--98591457(+) AAAAA-/TAAGCA 2 -- int10--------
    rs802537151,2
    C--98598471(+) ATATCC/TTTTCT 2 -- us2k10--------
    rs172938231,2
    C,F,H--102529896(+) TCACTG/AATTTT 2 -- ds500123Minor allele frequency- A:0.06NA NS EA 2070
    rs1468277071,2
    --102529934(+) ATGGGG/TCAAGG 2 -- ds50010--------
    rs1404903161,2
    --102529985(+) AATTCC/TATGTG 2 -- ds50010--------
    rs178806811,2
    C,F--102530027(-) GTGGGA/GAATGA 2 -- ds50011Minor allele frequency- G:0.01NS 178
    rs79451891,2
    C,F,H--102530053(+) ATTGTC/TTACTT 2 -- ds500127Minor allele frequency- T:0.06NS EA NA 3410
    rs1899183351,2
    --102530062(+) TTCCCA/GTTTCA 2 -- ds50010--------
    rs1922232831,2
    --102530175(+) CAAACA/TTAAAA 2 -- ut310--------
    rs1843808591,2
    C--102530221(+) ATCCAA/GGGTGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MMP1 (102660641 - 102668966 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MMP1: --
    Human Gene Mutation Database (HGMD): MMP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120353   
    OMIM disorders: 606963  226600  
    Selected diseases for MMP1 (see all 238):    About MalaCards
    epidermolysis bullosa dystrophica, autosomal recessive, modifier of    copd, rate of decline of lung function in    synovitis    superior limbic keratoconjunctivitis
    epidermolysis bullosa dystrophica    epidermolysis bullosa dystrophica, ar    pseudogout    arthritis
    gingivitis    oral submucous fibrosis    pulpitis    epidermolysis bullosa pruriginosa
    conjunctivochalasis    gingival overgrowth    malignant ovarian cyst    fibromatosis, gingival
    choledochal cyst    enthesitis-related arthritis    skin atrophy    carotid stenosis

    8 diseases from the University of Copenhagen DISEASES database for MMP1:
    Arthritis     Periodontal disease     Heart disease     Carcinoma
    Atherosclerosis     Lung disease     Synovitis     Breast cancer

    MMP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MMP1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 72.4 37 11908571 (2), 9512498 (2), 15743480 (2), 16688934 (2) (see all 24)
    rheumatoid arthritis 68.3 83 12447637 (3), 15292813 (2), 8849537 (2), 12509618 (2) (see all 58)
    metastasis 63.1 161 18360703 (5), 19608765 (4), 10794801 (4), 9649139 (4) (see all 83)
    tumors 61.3 375 18360703 (5), 12218298 (5), 16267613 (4), 17663001 (4) (see all 99)
    gingival overgrowth 60.5 12 18261580 (2), 17956473 (2), 15183848 (1), 16670920 (1) (see all 7)
    necrosis 58.9 104 18627438 (3), 17990358 (2), 19661147 (2), 16488289 (2) (see all 84)
    atherosclerotic plaque 56.6 44 8774133 (4), 15073384 (4), 15621056 (3), 11866921 (2) (see all 23)
    arthritis 54.4 32 12010565 (3), 10334680 (2), 11665967 (2), 12447637 (2) (see all 20)
    inflammation 53.5 44 19160981 (2), 11240267 (1), 11084020 (1), 12928151 (1) (see all 35)
    chronic periodontitis 53.5 18 15257748 (4), 12622858 (3), 19758971 (2), 18710412 (2) (see all 9)

    Genetic Association Database (GAD): MMP1
    Human Genome Epidemiology (HuGE) Navigator: MMP1 (224 documents)

    Export disorders for MMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMP1 gene, integrated from 10 sources (see all 2393):
    (articles sorted by number of sources associating them with MMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese. (PubMed id 16937230)1, 4, 9 Xu E....Huang Q. (Dis. Colon Rectum 2006)
    2. Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels. (PubMed id 20031604)1, 4, 9 Cheng Y.C....Pollin T.I. (Circ Cardiovasc Genet 2009)
    3. Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer. (PubMed id 19639194)1, 4, 9 Tsuchiya N....Habuchi T. (Oncol. Rep. 2009)
    4. Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes. (PubMed id 18178580)1, 4, 9 Wang H....Strauss J.F. (Hum. Mol. Genet. 2008)
    5. Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer. (PubMed id 12969782)1, 4, 9 Wenham R.M....Berchuck A. (J. Soc. Gynecol. Investig. 2003)
    6. Lack of association of a functionally relevant single nucleotide polymorphism of matrix metalloproteinase-1 promoter with systemic sclerosis (scleroderma). (PubMed id 11528521)1, 4, 9 Johnson R.W....Tan F.K. (Genes Immun. 2001)
    7. Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins. (PubMed id 19508478)1, 4, 9 Kurzawski M....DroA_dzik M. (Clin. Exp. Dermatol. 2009)
    8. Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population. (PubMed id 16899023)1, 4, 9 Astolfi C.M....de Souza A.P. (J. Clin. Periodontol. 2006)
    9. The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China. (PubMed id 15879464)1, 4, 9 Shan K....Yan L. (Mol. Hum. Reprod. 2005)
    10. Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. (PubMed id 19293200)1, 4, 9 McAloon C.J....Stockley R.A. (Ther Adv Respir Dis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4312 HGNC: 7155 AceView: MMP1 Ensembl:ENSG00000196611 euGenes: HUgn4312
    ECgene: MMP1 Kegg: 4312 H-InvDB: MMP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MMP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mmp1/
    Wikipedia http://en.wikipedia.org/wiki/Collagenase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MMP1 gene:
    Search GeneIP for patents involving MMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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