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Aliases for MMP1 Gene

Aliases for MMP1 Gene

  • Matrix Metallopeptidase 1 2 3 5
  • Fibroblast Collagenase 3 4
  • EC 3.4.24.7 4 63
  • CLG 3 4
  • Matrix Metalloproteinase 1 (Interstitial Collagenase) 2
  • Matrix Metallopeptidase 1 (Interstitial Collagenase) 3
  • Matrix Metalloproteinase 1 3
  • Matrix Metalloproteinase-1 4
  • Interstitial Collagenase 2
  • Matrix Metalloprotease 1 3
  • EC 3.4.24 63
  • MMP-1 4
  • CLGN 3

External Ids for MMP1 Gene

Previous HGNC Symbols for MMP1 Gene

  • CLG

Previous GeneCards Identifiers for MMP1 Gene

  • GC11M104854
  • GC11M104017
  • GC11M102694
  • GC11M102198
  • GC11M102165
  • GC11M102660
  • GC11M098588

Summaries for MMP1 Gene

Entrez Gene Summary for MMP1 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP1 Gene

MMP1 (Matrix Metallopeptidase 1) is a Protein Coding gene. Diseases associated with MMP1 include epidermolysis bullosa dystrophica, ar and pulmonary disease, chronic obstructive. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP1 Gene

  • Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tats mediated neurotoxicity.

Tocris Summary for MMP1 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP1 Gene

Genomics for MMP1 Gene

Regulatory Elements for MMP1 Gene

Promoters for MMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP1 Gene

Chromosome:
11
Start:
102,789,910 bp from pter
End:
102,798,235 bp from pter
Size:
8,326 bases
Orientation:
Minus strand

Genomic View for MMP1 Gene

Genes around MMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP1 Gene

Proteins for MMP1 Gene

  • Protein details for MMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03956-MMP1_HUMAN
    Recommended name:
    Interstitial collagenase
    Protein Accession:
    P03956
    Secondary Accessions:
    • P08156

    Protein attributes for MMP1 Gene

    Size:
    469 amino acids
    Molecular mass:
    54007 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for MMP1 Gene

neXtProt entry for MMP1 Gene

Proteomics data for MMP1 Gene at MOPED

Post-translational modifications for MMP1 Gene

  • Tyrosine phosphorylated in platelets by PKDCC/VLK.
  • Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
  • Glycosylation at Asn 120
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MMP1 Gene

Gene Families for MMP1 Gene

Suggested Antigen Peptide Sequences for MMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P03956

UniProtKB/Swiss-Prot:

MMP1_HUMAN :
  • There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP1: view

Function for MMP1 Gene

Molecular function for MMP1 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 1,regulator of matrix remodeling component of the MMP cluster,prognostic factor in case of advanced gastric and ovarian cancers,activated by host/tumor cell interaction and mediating the invasive/metastatic behavior of tumor cells through invasion of type I collagen,overexpressed in inflammatory bowel diseases
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly- -Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1 is a hydrophobic residue.
UniProtKB/Swiss-Prot EnzymeRegulation:
Can be activated without removal of the activation peptide.
UniProtKB/Swiss-Prot Function:
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tats mediated neurotoxicity.

Enzyme Numbers (IUBMB) for MMP1 Gene

Gene Ontology (GO) - Molecular Function for MMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,TAS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP1: view
genes like me logo Genes that share phenotypes with MMP1: view

Human Phenotype Ontology for MMP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MMP1 Gene

MGI Knock Outs for MMP1:

Animal Model Products

miRNA for MMP1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MMP1 Gene

Localization for MMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP1 Gene COMPARTMENTS Subcellular localization image for MMP1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
vacuole 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MMP1 Gene

Pathways & Interactions for MMP1 Gene

genes like me logo Genes that share pathways with MMP1: view

Gene Ontology (GO) - Biological Process for MMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0032461 positive regulation of protein oligomerization IDA 19022250
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MMP1: view

No data available for SIGNOR curated interactions for MMP1 Gene

Drugs & Compounds for MMP1 Gene

(86) Drugs for MMP1 Gene - From: Novoseek, HMDB, DGIdb, ApexBio, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
Zinc Approved Pharma 1477
Collagenase Approved, Investigational Pharma 0
[[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER Experimental Pharma Target 0
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID Experimental Pharma Target 0

(66) Additional Compounds for MMP1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP1 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4

(4) ApexBio Compounds for MMP1 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor 130370-60-4
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent 10592-13-9
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
Marimastat MMPs inhibitor,board spectrum 154039-60-8
genes like me logo Genes that share compounds with MMP1: view

Drug Products

Transcripts for MMP1 Gene

mRNA/cDNA for MMP1 Gene

(2) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(375) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP1 Gene

Matrix metallopeptidase 1 (interstitial collagenase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP1 Gene

No ASD Table

Relevant External Links for MMP1 Gene

GeneLoc Exon Structure for
MMP1
ECgene alternative splicing isoforms for
MMP1

Expression for MMP1 Gene

mRNA expression in normal human tissues for MMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for MMP1 Gene

This gene is overexpressed in Urine (25.5), Amniocyte (24.5), and Synovial fluid (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP1 Gene



SOURCE GeneReport for Unigene cluster for MMP1 Gene Hs.83169

genes like me logo Genes that share expression patterns with MMP1: view

Protein tissue co-expression partners for MMP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MMP1 Gene

Orthologs for MMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100848085 35
  • 86.36 (n)
  • 86 (a)
MMP1 36
  • 85 (a)
OneToMany
MMP1 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC489428 35
  • 85.09 (n)
  • 82.02 (a)
MMP1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp1a 35
  • 71.54 (n)
  • 59.65 (a)
Mmp1a 16
Mmp1a 36
  • 59 (a)
OneToMany
Mmp1b 36
  • 58 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MMP1 35
  • 99.5 (n)
  • 99.36 (a)
MMP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp1 35
  • 70.45 (n)
  • 58.35 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP1 35
  • 66.3 (n)
  • 59.73 (a)
-- 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia mmp1-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7607 35
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 44 (a)
Species with no ortholog for MMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP1 Gene

ENSEMBL:
Gene Tree for MMP1 (if available)
TreeFam:
Gene Tree for MMP1 (if available)

Paralogs for MMP1 Gene

(17) SIMAP similar genes for MMP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MMP1 Gene

genes like me logo Genes that share paralogs with MMP1: view

Variants for MMP1 Gene

Sequence variations from dbSNP and Humsavar for MMP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_054005 -
VAR_021026 -
VAR_021025 -
VAR_021024 -
VAR_011970 -

Variation tolerance for MMP1 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP1 Gene

HapMap Linkage Disequilibrium report
MMP1
Human Gene Mutation Database (HGMD)
MMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MMP1 Gene

Disorders for MMP1 Gene

MalaCards: The human disease database

(67) MalaCards diseases for MMP1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermolysis bullosa dystrophica, ar
  • ebd inversa
pulmonary disease, chronic obstructive
  • copd, rate of decline of lung function in
preterm premature rupture of the membranes
  • preterm premature rupture of the membranes, susceptibility to
gingival overgrowth
  • gingival enlargement
localized scleroderma
  • circumscribed scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search MMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP1

Genetic Association Database (GAD)
MMP1
Human Genome Epidemiology (HuGE) Navigator
MMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP1
genes like me logo Genes that share disorders with MMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP1 Gene

Publications for MMP1 Gene

  1. No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese. (PMID: 16937230) Xu E. … Huang Q. (Dis. Colon Rectum 2006) 3 48 67
  2. Effect of matrix metalloproteinase-1 promoter genotype on interleukin-1beta-induced matrix metalloproteinase-1 production in human periodontal ligament cells. (PMID: 19602108) Cao Z. … Xiang J. (J. Periodont. Res. 2010) 3 23
  3. [Expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in human and nude mouse ectopic endometrium and the effect of estrogen and progestin on their expression]. (PMID: 20423842) Lou Y.H. … Xia Y.F. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 3 23
  4. IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun. (PMID: 20225236) Li Y. … Huang Y. (J. Cell. Biochem. 2010) 3 23
  5. A comparative study of protein expression in primary colorectal cancer and synchronous hepatic metastases: the significance of matrix metalloproteinase-1 expression as a predictor of liver metastasis. (PMID: 20095886) Kim Y.W. … Kim H. (Scand. J. Gastroenterol. 2010) 3 23

Products for MMP1 Gene

Sources for MMP1 Gene

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