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Aliases for MMGT1 Gene

Aliases for MMGT1 Gene

  • Membrane Magnesium Transporter 1 2 3
  • ER Membrane Protein Complex Subunit 5 2 3 4
  • Transmembrane Protein 32 2 3 4
  • TMEM32 3 4
  • EMC5 3 4

External Ids for MMGT1 Gene

Previous HGNC Symbols for MMGT1 Gene

  • TMEM32

Previous GeneCards Identifiers for MMGT1 Gene

  • GC0XM134872
  • GC0XM135045
  • GC0XM124318

Summaries for MMGT1 Gene

GeneCards Summary for MMGT1 Gene

MMGT1 (Membrane Magnesium Transporter 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MMGT1 Gene

  • Mediates Mg(2+) transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMGT1 Gene

Genomics for MMGT1 Gene

Regulatory Elements for MMGT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMGT1 Gene

135,962,070 bp from pter
135,974,063 bp from pter
11,994 bases
Minus strand

Genomic View for MMGT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMGT1 Gene

Proteins for MMGT1 Gene

  • Protein details for MMGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane magnesium transporter 1
    Protein Accession:
    Secondary Accessions:
    • B2R625
    • B4DIY3
    • D3DWG7
    • Q5JPP7

    Protein attributes for MMGT1 Gene

    131 amino acids
    Molecular mass:
    14686 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for MMGT1 Gene


neXtProt entry for MMGT1 Gene

Proteomics data for MMGT1 Gene at MOPED

Post-translational modifications for MMGT1 Gene

  • Ubiquitination at Lys122
  • Modification sites at PhosphoSitePlus

Other Protein References for MMGT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MMGT1

No data available for DME Specific Peptides for MMGT1 Gene

Domains for MMGT1 Gene

Protein Domains for MMGT1 Gene


Suggested Antigen Peptide Sequences for MMGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the membrane magnesium transporter (TC 1.A.67) family.
  • Belongs to the membrane magnesium transporter (TC 1.A.67) family.
genes like me logo Genes that share domains with MMGT1: view

No data available for Gene Families for MMGT1 Gene

Function for MMGT1 Gene

Molecular function for MMGT1 Gene

UniProtKB/Swiss-Prot Function:
Mediates Mg(2+) transport.

Gene Ontology (GO) - Molecular Function for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with MMGT1: view

Phenotypes for MMGT1 Gene

GenomeRNAi human phenotypes for MMGT1:
genes like me logo Genes that share phenotypes with MMGT1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMGT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MMGT1 Gene

Localization for MMGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMGT1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Detected in the Golgi apparatus and in post-Golgi vesicles including early endosomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for MMGT1 Gene COMPARTMENTS Subcellular localization image for MMGT1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005769 early endosome ISS --
GO:0005794 Golgi apparatus ISS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 22119785
genes like me logo Genes that share ontologies with MMGT1: view

Pathways for MMGT1 Gene

SuperPathways for MMGT1 Gene

No Data Available

Interacting Proteins for MMGT1 Gene

Gene Ontology (GO) - Biological Process for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport ISS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with MMGT1: view

No data available for Pathways by source for MMGT1 Gene

Transcripts for MMGT1 Gene

mRNA/cDNA for MMGT1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(153) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMGT1 Gene

Membrane magnesium transporter 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMGT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMGT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP2: - -
SP3: -

Relevant External Links for MMGT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMGT1 Gene

mRNA expression in normal human tissues for MMGT1 Gene

Protein differential expression in normal tissues for MMGT1 Gene

This gene is overexpressed in Bone (18.4) and Placenta (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MMGT1 Gene

SOURCE GeneReport for Unigene cluster for MMGT1 Gene Hs.110702

genes like me logo Genes that share expressions with MMGT1: view

Expression partners for MMGT1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MMGT1 Gene

Orthologs for MMGT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMGT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MMGT1 35
  • 95.42 (n)
  • 98.47 (a)
MMGT1 36
  • 79 (a)
(Canis familiaris)
Mammalia MMGT1 35
  • 94.91 (n)
  • 96.95 (a)
(Mus musculus)
Mammalia Mmgt1 35
  • 90.59 (n)
  • 95.42 (a)
Mmgt1 16
Mmgt1 36
  • 95 (a)
Mmgt2 36
  • 66 (a)
(Pan troglodytes)
Mammalia MMGT1 35
  • 99.75 (n)
  • 100 (a)
MMGT1 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Mmgt1 35
  • 90.08 (n)
  • 95.42 (a)
(Monodelphis domestica)
Mammalia MMGT1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MMGT1 36
  • 83 (a)
(Gallus gallus)
Aves MMGT1 35
  • 82.56 (n)
  • 92.31 (a)
MMGT1 36
  • 89 (a)
(Anolis carolinensis)
Reptilia MMGT1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmgt1 35
  • 77.61 (n)
  • 82.44 (a)
(Danio rerio)
Actinopterygii mmgt1 35
  • 68.49 (n)
  • 80.47 (a)
mmgt1 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009134 35
  • 52.01 (n)
  • 47.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15168 35
  • 55.11 (n)
  • 54.67 (a)
CG15168 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea emc-5 36
  • 28 (a)
Species with no ortholog for MMGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMGT1 Gene

Gene Tree for MMGT1 (if available)
Gene Tree for MMGT1 (if available)

Paralogs for MMGT1 Gene

No data available for Paralogs for MMGT1 Gene

Variants for MMGT1 Gene

Sequence variations from dbSNP and Humsavar for MMGT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs577248976 -- 135,968,498(+) ATGTC(A/G)TTGTG intron-variant
rs574895019 -- 135,965,268(+) TATCA(A/T)TTTAC intron-variant
rs572823248 -- 135,968,131(+) ACAGG(C/T)GTGAG intron-variant
rs571642825 -- 135,964,172(+) CAGAG(C/T)TTGAA utr-variant-3-prime
rs568972343 -- 135,972,850(+) ATACT(G/T)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMGT1 Gene

Variant ID Type Subtype PubMed ID
esv785 CNV CNV 17122850
essv24688 CNV CNV 17122850
nsv527358 CNV Gain 19592680

Relevant External Links for MMGT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMGT1 Gene

Disorders for MMGT1 Gene

No disorders were found for MMGT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MMGT1 Gene

Publications for MMGT1 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4
  2. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4
  3. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. (PMID: 18057121) Goytain A. … Quamme G.A. (Am. J. Physiol., Cell Physiol. 2008) 2 3
  4. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3

Products for MMGT1 Gene

Sources for MMGT1 Gene

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