MMGT1 Gene
protein-coding GIFtS: 43
GCID: GC0XM135045
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membrane magnesium transporter 1(Previous name: transmembrane protein 32 )
(Previous symbol: TMEM32)
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Aliases
for MMGT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane Magnesium Transporter 11 2 | | Transmembrane Protein 321 2 3 | | EMC51 2 3 | | TMEM321 2 3 | | ER Membrane Protein Complex Subunit 52 3 |
Export aliases for MMGT1 gene to outside databasesPrevious GC identifers: GC0XM134872 GC0XM124318 |
Summaries
for MMGT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MMGT1_HUMAN, Q8N4V1Function: Mediates Mg(2+) transport (By similarity)
|
Genomic Views
for MMGT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MMGT1 gene promoter:
ATF-2 CUTL1 POU6F1 (c2) HNF-3beta LCR-F1 Gfi-1 Evi-1 c-Ets-1 AREB6 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for MMGT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMGT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3MMGT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM135045: view genomic region
(about GC identifiers)
Start:
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135,044,229 bp from pter |
End:
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135,056,222 bp from pter |
Size:
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11,994 bases |
Orientation:
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minus strand |
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Proteins
for MMGT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MMGT1_HUMAN, Q8N4V1 (See
protein sequence)Recommended Name: Membrane magnesium transporter 1 precursor Size: 131 amino acids; 14686 Da
Subunit: Component of the ER membrane protein complex (EMC)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane;Single-pass type I membrane protein (By similarity). Early endosome membrane; Single-pass type I membrane protein (Bysimilarity). Note=Detected in the Golgi apparatus and in post-Golgi vesicles including early endosomes (By similarity)
Secondary accessions: B2R625 B4DIY3 D3DWG7 Q5JPP7Alternative splicing: 2 isoforms: Q8N4V1-1 Q8N4V1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MMGT1: NX_Q8N4V1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4V1
MMGT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775741.1
ENSEMBL proteins: ENSP00000306220 ENSP00000411359
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
MMGT1 for ontologies About GeneDecksing
MMGT1 Antibody Products:
Assay Products for MMGT1: |
Protein
Domains /
Families
for MMGT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MMGT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N4V1ProtoNet protein and cluster: Q8N4V1 UniProtKB/Swiss-Prot: MMGT1_HUMAN, Q8N4V1Similarity: Belongs to the membrane magnesium transporter (TC 1.A.67) family |
Function
for MMGT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MMGT1_HUMAN, Q8N4V1Function: Mediates Mg(2+) transport (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MMGT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMGT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMGT1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005375 | copper ion transmembrane transporter activity |
IEA | -- | | GO:0005384 | manganese ion transmembrane transporter activity |
IEA | -- | | GO:0015087 | cobalt ion transmembrane transporter activity |
IEA | -- | | GO:0015095 | magnesium ion transmembrane transporter activity |
ISS | -- | | GO:0015099 | nickel cation transmembrane transporter activity |
IEA | -- |
MMGT1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MMGT1:
|
Pathways & Interactions
for MMGT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMGT1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MMGT1 (ENSP000003062204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015693 | magnesium ion transport |
ISS | -- |
MMGT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MMGT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MMGT1
Search CenterWatch for drugs/clinical trials and news about MMGT1
|
Transcripts
for MMGT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MMGT1 gene: NM_173470.1 Unigene Cluster for MMGT1: Membrane magnesium transporter 1 Hs.110702 [show with all ESTs]Unigene Representative Sequence: NM_1734702 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305963(uc022cet.1 uc004ezi.1 uc011mvw.1) ENST00000433339
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MMGT1 (NM_173470) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMGT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMGT1 |
Additional cDNA sequence: AK295829.1 AK312409.1 AL157477.1 BC033588.1 7 DOTS entries: DT.113468 DT.97843130 DT.95372910 DT.95372913 DT.101960709 DT.75102838 DT.91728590 24/153 AceView cDNA sequences (see all 153): CD675144 AI418501 CK819984 AA251452 AA126085 BM970040 BC033588 BU177058 AI264186 BF435985 CB131193 CD723453 BQ003522 BQ425704 AA311076 BM273278 BM698421 CF265192 BE542759 BM664568 CB306478 AW103391 NM_173470 AA370068
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MMGT1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | |
| SP3: | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for MMGT1
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Expression
for MMGT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MMGT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTATTGAA
About this image
See MMGT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMGT1
SOURCE GeneReport for Unigene cluster: Hs.110702
SABiosciences Custom PCR Arrays for MMGT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMGT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMGT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMGT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMGT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMGT1 |
Orthologs
for MMGT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MMGT1 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for MMGT1 (if available)
TreeFam Gene Tree for MMGT1 (if available) |
Paralogs
for MMGT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MMGT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MMGT1 (135044229 - 135056222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MMGT1
1 CNV: 4174 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMGT1 |
|
Disorders
/ Diseases
for MMGT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MMGT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MMGT1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MMGT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Defining human ERAD networks through an integrative mapping strategy. (PubMed id 22119785)1, 2, 3 Christianson J.C.... Kopito R.R. (2012)
- Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. (PubMed id 18057121)1, 3 Goytain A. and Quamme G.A. (2008)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1, 2 Simpson J.C.... Wiemann S. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for MMGT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MMGT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MMGT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MMGT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MMGT1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MMGT1 gene:
Search GeneIP for patents involving MMGT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MMGT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MMGT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMGT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMGT1 | | | OriGene Protein Over-expression Lysate for MMGT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MMGT1 | | OriGene 3'-UTR Clone for MMGT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMGT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMGT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMGT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMGT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMGT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMGT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMGT1 |
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 | | | MMGT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMGT1 |
|  |  |  | | | | ThermoFisher Antibody for MMGT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMGT1 |
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