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Aliases for MMGT1 Gene

Aliases for MMGT1 Gene

  • Membrane Magnesium Transporter 1 2 3 5
  • ER Membrane Protein Complex Subunit 5 2 3 4
  • Transmembrane Protein 32 2 3 4
  • TMEM32 3 4
  • EMC5 3 4

External Ids for MMGT1 Gene

Previous HGNC Symbols for MMGT1 Gene

  • TMEM32

Previous GeneCards Identifiers for MMGT1 Gene

  • GC0XM134872
  • GC0XM135045
  • GC0XM124318

Summaries for MMGT1 Gene

GeneCards Summary for MMGT1 Gene

MMGT1 (Membrane Magnesium Transporter 1) is a Protein Coding gene. Among its related pathways are Miscellaneous transport and binding events and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MMGT1 Gene

  • Mediates Mg(2+) transport.

Additional gene information for MMGT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMGT1 Gene

Genomics for MMGT1 Gene

Regulatory Elements for MMGT1 Gene

Enhancers for MMGT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH136054 1 Ensembl ENCODE dbSUPER 16.2 -81.8 -81832 2.5 JUND JUN ZNF600 NR2F2 MMGT1 FHL1 MAP7D3 GAPDHP67
GH0XH136063 1.4 Ensembl ENCODE dbSUPER 5.2 -90.5 -90452 2.9 PKNOX1 ZSCAN4 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZBTB40 ZNF366 SCRT2 MMGT1 GAPDHP67
GH0XH135972 1 ENCODE 5.4 +0.2 232 2.6 ATF1 ARNT ARID4B SIN3A BRCA1 ZNF2 YY1 GLIS2 ELK1 ZNF143 CT45A1 MMGT1 SLC9A6 GC0XM135957
GH0XH136029 0.9 Ensembl ENCODE 4.5 -56.4 -56437 2.9 ZNF639 KLF1 KLF17 ZEB2 OSR2 PRDM6 ZNF629 ZSCAN5C ZXDB ZNF18 MMGT1 GAPDHP67
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMGT1 on UCSC Golden Path with GeneCards custom track

Promoters for MMGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249019 263 2401 ATF1 ARNT ARID4B SIN3A BRCA1 ZNF2 YY1 GLIS2 ELK1 ZNF143

Genomic Locations for MMGT1 Gene

Genomic Locations for MMGT1 Gene
11,994 bases
Minus strand

Genomic View for MMGT1 Gene

Genes around MMGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMGT1 Gene

Proteins for MMGT1 Gene

  • Protein details for MMGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane magnesium transporter 1
    Protein Accession:
    Secondary Accessions:
    • B2R625
    • B4DIY3
    • D3DWG7
    • Q5JPP7

    Protein attributes for MMGT1 Gene

    131 amino acids
    Molecular mass:
    14686 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for MMGT1 Gene


neXtProt entry for MMGT1 Gene

Post-translational modifications for MMGT1 Gene

  • Ubiquitination at posLast=122122
  • Modification sites at PhosphoSitePlus

Other Protein References for MMGT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMGT1 Gene

Domains & Families for MMGT1 Gene

Gene Families for MMGT1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MMGT1 Gene


Suggested Antigen Peptide Sequences for MMGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the membrane magnesium transporter (TC 1.A.67) family.
  • Belongs to the membrane magnesium transporter (TC 1.A.67) family.
genes like me logo Genes that share domains with MMGT1: view

Function for MMGT1 Gene

Molecular function for MMGT1 Gene

UniProtKB/Swiss-Prot Function:
Mediates Mg(2+) transport.

Phenotypes From GWAS Catalog for MMGT1 Gene

Gene Ontology (GO) - Molecular Function for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity ISS --
GO:0022890 inorganic cation transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with MMGT1: view

Phenotypes for MMGT1 Gene

GenomeRNAi human phenotypes for MMGT1:
genes like me logo Genes that share phenotypes with MMGT1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMGT1 Gene

Localization for MMGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMGT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMGT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
golgi apparatus 4
endosome 4
extracellular 3

Gene Ontology (GO) - Cellular Components for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome ISS,IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with MMGT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMGT1 Gene

Pathways & Interactions for MMGT1 Gene

genes like me logo Genes that share pathways with MMGT1: view

Pathways by source for MMGT1 Gene

Gene Ontology (GO) - Biological Process for MMGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015693 magnesium ion transport ISS --
GO:0098655 cation transmembrane transport IBA --
GO:1903830 magnesium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with MMGT1: view

No data available for SIGNOR curated interactions for MMGT1 Gene

Drugs & Compounds for MMGT1 Gene

No Compound Related Data Available

Transcripts for MMGT1 Gene

mRNA/cDNA for MMGT1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(153) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMGT1 Gene

Membrane magnesium transporter 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMGT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP2: - -
SP3: -

Relevant External Links for MMGT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMGT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMGT1 Gene

Protein differential expression in normal tissues from HIPED for MMGT1 Gene

This gene is overexpressed in Bone (18.4) and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MMGT1 Gene

Protein tissue co-expression partners for MMGT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMGT1 Gene:


SOURCE GeneReport for Unigene cluster for MMGT1 Gene:


Evidence on tissue expression from TISSUES for MMGT1 Gene

  • Nervous system(4.8)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with MMGT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMGT1 Gene

Orthologs for MMGT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMGT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MMGT1 33 34
  • 99.75 (n)
(Bos Taurus)
Mammalia MMGT1 33 34
  • 95.42 (n)
(Canis familiaris)
Mammalia MMGT1 33
  • 94.91 (n)
(Mus musculus)
Mammalia Mmgt1 33 16 34
  • 90.59 (n)
Mmgt2 34
  • 66 (a)
(Rattus norvegicus)
Mammalia Mmgt1 33
  • 90.08 (n)
(Monodelphis domestica)
Mammalia MMGT1 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MMGT1 34
  • 83 (a)
(Gallus gallus)
Aves MMGT1 33 34
  • 82.56 (n)
(Anolis carolinensis)
Reptilia MMGT1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmgt1 33
  • 77.61 (n)
(Danio rerio)
Actinopterygii mmgt1 33 34
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15168 33 34
  • 55.11 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009134 33
  • 52.01 (n)
(Caenorhabditis elegans)
Secernentea emc-5 34
  • 28 (a)
Species where no ortholog for MMGT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMGT1 Gene

Gene Tree for MMGT1 (if available)
Gene Tree for MMGT1 (if available)

Paralogs for MMGT1 Gene

No data available for Paralogs for MMGT1 Gene

Variants for MMGT1 Gene

Sequence variations from dbSNP and Humsavar for MMGT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000118806 -- 135,970,638(+) GGCGC(G/T)GTGGC intron-variant
rs1000519796 -- 135,970,385(+) AAAAA(C/T)TAAAA intron-variant
rs1000935744 -- 135,963,283(+) AGTGA(A/C)TTGTA utr-variant-3-prime
rs1000981854 -- 135,963,634(+) TTTGG(A/G)GCTAT utr-variant-3-prime
rs1001114875 -- 135,972,869(+) AGTTC(C/T)CCCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMGT1 Gene

Variant ID Type Subtype PubMed ID
nsv953696 CNV deletion 24416366
nsv527358 CNV gain 19592680
nsv1076276 CNV deletion 25765185
esv3574714 CNV loss 25503493
esv2758895 CNV gain+loss 17122850

Variation tolerance for MMGT1 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMGT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMGT1 Gene

Disorders for MMGT1 Gene

Relevant External Links for MMGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MMGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMGT1 Gene

Publications for MMGT1 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4 60
  2. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. (PMID: 18057121) Goytain A … Quamme GA (American journal of physiology. Cell physiology 2008) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for MMGT1 Gene

Sources for MMGT1 Gene

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