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MMEL1 Gene

protein-coding   GIFtS: 55
GCID: GC01M002557

Membrane Metallo-Endopeptidase-Like 1

(Previous name: membrane metallo-endopeptidase-like 2)
(Previous symbol: MMEL2)
  See MMEL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Metallo-Endopeptidase-Like 11 2     NL12
Membrane Metallo-Endopeptidase-Like 21 2 3     SEP2
MMEL21 2 3     neprilysin-22
Neprilysin II2 3     Soluble Secreted Endopeptidase2
NEP22 3     Zinc Metallopeptidase2
NEP2(m)2 3     MELL13
NEPII2 3     Neprilysin-23
NL22 3     EC 3.4.248
EC 3.4.24.113 8     

External Ids:    HGNC: 146681   Entrez Gene: 792582   Ensembl: ENSG000001426067   UniProtKB: Q495T63   

Export aliases for MMEL1 gene to outside databases

Previous GC identifers: GC00U990694 GC01M001803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMEL1 Gene:
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase
(MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate
metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a
secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MMEL1 Gene:
MMEL1 (membrane metallo-endopeptidase-like 1) is a protein-coding gene. Diseases associated with MMEL1 include primary biliary cirrhosis. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is PHEX.

UniProtKB/Swiss-Prot: MMEL1_HUMAN, Q495T6
Function: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and
early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter
than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate
specificity with MME and cleaves peptides at the same amide bond (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  NT_187515.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMEL1 gene promoter:
         AREB6   GR   GR-beta   ZID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMEL1 promoter sequence
   Search Chromatin IP Primers for MMEL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMEL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36

MMEL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMEL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M002557:  view genomic region     (about GC identifiers)

Start:
2,522,078 bp from pter      End:
2,564,481 bp from pter
Size:
42,404 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MMEL1_HUMAN, Q495T6 (See protein sequence)
Recommended Name: Membrane metallo-endopeptidase-like 1  
Size: 779 amino acids; 89367 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=AAI01028.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI01031.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL08942.1;
Type=Frameshift; Positions=7, 8;
Secondary accessions: B9DI79 Q495T7 Q495T8 Q5SZS6 Q96PH9
Alternative splicing: 3 isoforms:  Q495T6-1   Q495T6-2   Q495T6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MMEL1: NX_Q495T6

Explore proteomics data for MMEL1 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn177, Asn207, Asn350, Asn530, Asn657
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MMEL1 (Q495T6) (see all 7)
     FPAGILQ  AVVNAFYS  SIKTDVHSP  FACGGWLRRH 


    See MMEL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_258428.2  
    ENSEMBL proteins: 
     ENSP00000461938   ENSP00000367668   ENSP00000422492   ENSP00000425477   ENSP00000288709  

    MMEL1 Human Recombinant Protein Products:

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    Novus Biologicals MMEL1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MMEL1 

     
    antibodies-online proteins for MMEL1 (2 products) 

     
    antibodies-online peptides for MMEL1

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    antibodies-online antibodies for MMEL1 (27 products) 

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for MMEL1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR000718 Peptidase_M13
     IPR018497 Peptidase_M13_C
     IPR008753 Peptidase_M13_N

    Graphical View of Domain Structure for InterPro Entry Q495T6

    ProtoNet protein and cluster: Q495T6

    2 Blocks protein domains:
    IPB000718 Neprilysin metalloprotease (M13) family signature
    IPB008753 Peptidase M13


    UniProtKB/Swiss-Prot: MMEL1_HUMAN, Q495T6
    Similarity: Belongs to the peptidase M13 family


    Find genes that share domains with MMEL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MMEL1_HUMAN, Q495T6
    Function: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and
    early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter
    than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate
    specificity with MME and cleaves peptides at the same amide bond (By similarity)
    Catalytic activity: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or
    Tyr at P1'
    Enzyme regulation: Inhibited by thiorphan and phosphoramidon (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.24.111 2 EC 3.4.242

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MMEL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MMEL1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mmel1):
     reproductive system 

    Find genes that share phenotypes with MMEL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mmel1tm1Ldg for MMEL1

       genOway: Develop your customized and physiologically relevant rodent model for MMEL1

    miRNA
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    miRTarBase miRNAs that target MMEL1:
    hsa-mir-335-5p (MIRT018444)

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    1 qRT-PCR Assays for microRNA that regulate MMEL1:
    hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidMMEL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MMEL1
    Predesigned siRNA for gene silencing in human, mouse, rat MMEL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMEL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MMEL1_HUMAN, Q495T6: Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by
    proteollytic cleavage also exists (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum2
    golgi apparatus2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MMEL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MMEL1 About    
    See pathways by source

    SuperPathContained pathways About
    1A-beta Uptake and Degradation
    A-beta Uptake and Degradation
    2A-beta Plaque Formation and APP Metabolism
    A-beta Plaque Formation and APP Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for MMEL1
        A-beta Uptake & Degradation
    A-beta Plaque Formation & APP Metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MMEL1
    Interactions:

        Search GeneGlobe Interaction Network for MMEL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MMEL1 (ENSP000002887094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP2ENSP000002635744STRING: ENSP00000263574
    APPENSP000002849814STRING: ENSP00000284981
    APLP1ENSP000002218914STRING: ENSP00000221891
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with MMEL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MMEL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MMEL1 gene: 
    NM_033467.3  

    Unigene Cluster for MMEL1:

    Membrane metallo-endopeptidase-like 1
    Hs.591453  [show with all ESTs]
    Unigene Representative Sequence: NM_033467
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471840 ENST00000378412 ENST00000502556 ENST00000504800 ENST00000491941
    ENST00000464195 ENST00000469962 ENST00000509374 ENST00000511099 ENST00000288709(uc009vlg.1 uc001ajy.2)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MMEL1:
    hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidMMEL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MMEL1
    Predesigned siRNA for gene silencing in human, mouse, rat MMEL1
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      QuantiFast Probe-based Assays in human, mouse, rat MMEL1

    Additional mRNA sequence: 

    AF336981.1 AK093058.1 BC101027.2 BC101028.1 BC101030.1 

    5 DOTS entries:

    DT.95111945  DT.97826519  DT.121368257  DT.121368320  DT.95259912 

    24 AceView cDNA sequences:

    CA405847 BF437289 NM_033467 AW372628 BF446399 AK093058 AX747891 AF336981 
    CD369886 BM853146 BI823929 CD637785 AI262100 BG991637 BI828288 AW373220 
    BI907511 BQ636494 AW845925 AW749924 CD637787 AW749935 AW393029 AW577304 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MMEL1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                
    SP4:                                -               


    ECgene alternative splicing isoforms for MMEL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMEL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGCCTGC
    MMEL1 Expression
    About this image


    MMEL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    MMEL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMEL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591453

    UniProtKB/Swiss-Prot: MMEL1_HUMAN, Q495T6
    Tissue specificity: Predominantly expressed in testis. Weakly expressed in brain, kidney and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMEL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmel11 , 5 membrane metallo-endopeptidase-like 11, 5 81.18(n)1
    78.43(a)1
      4 (85.54 cM)5
    273901  NM_013783.21  NP_038811.21 
     1548695855 
    chicken
    (Gallus gallus)
    Aves MMEL11 membrane metallo-endopeptidase-like 1 67.46(n)
    68.39(a)
      770671  XM_001233076.3  XP_001233077.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.135452 Transcribed sequence with weak similarity to protein more 71.95(n)    BX730705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmel11 membrane metallo-endopeptidase-like 1 64.14(n)
    61.13(a)
      560703  XM_684099.4  XP_689191.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nep41 Neprilysin 4 54.34(n)
    41.95(a)
      42449  NM_142647.3  NP_650904.3 
    worm
    (Caenorhabditis elegans)
    Secernentea nep-21 nep-2 49.41(n)
    40(a)
      188090  NM_061942.2  NP_494343.2 


    ENSEMBL Gene Tree for MMEL1 (if available)
    TreeFam Gene Tree for MMEL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMEL1 gene
    PHEX2  MME2  KEL2  ECE22  ECE12  ECEL12  
    6 SIMAP similar genes for MMEL1 using alignment to 2 protein entries:     MMEL1_HUMAN (see all proteins):
    MME    ECE2    ECE1    PHEX    ECEL1    KEL

    Find genes that share paralogs with MMEL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMEL1 (see all 1054)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57720701,2
    C,F--2523661(+) CCCTCG/-GGGGG 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1424464111,2
    C--2523696(+) GCACAC/GCACCT 1 -- int10--------
    rs8674351,2
    C,A--2523706(+) TGTCCC/TGAATG 1 -- int15Minor allele frequency- T:0.49CSA WA NA EA 361
    rs8674361,2
    C,F,A,H--2523723(+) TGACGT/CCCCCT 1 -- int1 trp317Minor allele frequency- C:0.50NS EA NA CSA WA 2213
    rs1122186521,2
    C,F--2523744(+) ACTGGC/TGCCCC 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1999133691,2
    C--2523770(+) CTGAT-/CCCCCC 1 -- int10--------
    rs1923494271,2
    --2523807(+) CCCTGA/CTGTGC 1 -- int10--------
    rs1824641811,2
    --2523810(+) TGCTGC/TGCTGG 1 -- int10--------
    rs1877861741,2
    --2523811(+) GCTGTA/GCTGGC 1 -- int10--------
    rs1400731571,2
    C--2523818(+) TGGCAC/TCCCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MMEL1 (2522078 - 2564481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MMEL1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719917CNV Deletion23290073
    esv2719806CNV Deletion23290073
    esv2719695CNV Deletion23290073
    dgv75n71CNV Loss21882294
    dgv71n71CNV Loss21882294
    dgv85n71CNV Loss21882294
    nsv870655CNV Loss21882294
    nsv871726CNV Loss21882294
    nsv470684CNV Loss18288195
    nsv870979CNV Loss21882294

    Human Gene Mutation Database (HGMD): MMEL1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MMEL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MMEL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MMEL1:    
    About MalaCards
    primary biliary cirrhosis


    Find genes that share disorders with MMEL1           About GenesLikeMe

    Genetic Association Database (GAD): MMEL1
    Human Genome Epidemiology (HuGE) Navigator: MMEL1 (9 documents)

    Export disorders for MMEL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMEL1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MMEL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family. (PubMed id 11560781)1, 2, 9 Bonvouloir N.... DesGroseillers L. (DNA Cell Biol. 2001)
    2. Genetic variants in the prediction of rheumatoid arthritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (Ann. Rheum. Dis. 2010)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. (PubMed id 20639879)1, 4 Hirschfield G.M....Siminovitch K.A. (Nat. Genet. 2010)
    5. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PubMed id 19674979)1, 4 Hinks A....Thomson W. (Ann. Rheum. Dis. 2010)
    6. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    7. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    8. A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. (PubMed id 20049410)1, 4 Wieczorek S....Epplen J.T. (J. Mol. Med. 2010)
    9. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PubMed id 18794853)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2008)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79258 HGNC: 14668 AceView: MMEL2 Ensembl:ENSG00000142606 euGenes: HUgn79258
    ECgene: MMEL1 H-InvDB: MMEL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMEL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MMEL1 gene:
    Search GeneIP for patents involving MMEL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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