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Aliases for MME Gene

Aliases for MME Gene

  • Membrane Metallo-Endopeptidase 2 3
  • Enkephalinase 2 3 4
  • CALLA 3 4 6
  • NEP 3 4 6
  • Common Acute Lymphocytic Leukemia Antigen 3 4
  • Neutral Endopeptidase 24.11 3 4
  • Skin Fibroblast Elastase 3 4
  • Neutral Endopeptidase 2 4
  • Atriopeptidase 3 4
  • EC 3.4.24.11 4 63
  • Neprilysin 2 3
  • CD10 3 6
  • SFE 3 4
  • Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10) 3
  • Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase) 3
  • Membrane Metallo-Endopeptidase Variant 1 3
  • Membrane Metallo-Endopeptidase Variant 2 3
  • Neprilysin-390 3
  • Neprilysin-411 3
  • CD10 Antigen 4
  • EC 3.4.24 63
  • EPN 4

External Ids for MME Gene

Previous GeneCards Identifiers for MME Gene

  • GC03P151792
  • GC03P155641
  • GC03P156079
  • GC03P156118
  • GC03P156280
  • GC03P154741
  • GC03P152191

Summaries for MME Gene

Entrez Gene Summary for MME Gene

  • This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for MME Gene

MME (Membrane Metallo-Endopeptidase) is a Protein Coding gene. Diseases associated with MME include membranous glomerulonephritis, antenatal and pancreatic mucinous cystadenoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Alzheimers disease. GO annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is MMEL1.

UniProtKB/Swiss-Prot for MME Gene

  • Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Gene Wiki entry for MME Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MME Gene

Genomics for MME Gene

Regulatory Elements for MME Gene

Transcription factor binding sites by QIAGEN in the MME gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MME Gene

Start:
155,024,124 bp from pter
End:
155,183,729 bp from pter
Size:
159,606 bases
Orientation:
Plus strand

Genomic View for MME Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MME Gene

Proteins for MME Gene

  • Protein details for MME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08473-NEP_HUMAN
    Recommended name:
    Neprilysin
    Protein Accession:
    P08473
    Secondary Accessions:
    • A8K6U6
    • D3DNJ9
    • Q3MIX4

    Protein attributes for MME Gene

    Size:
    750 amino acids
    Molecular mass:
    85514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Important cell surface marker in the diagnostic of human acute lymphocytic leukemia
    SequenceCaution:
    • Sequence=CAA30157.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MME Gene

neXtProt entry for MME Gene

Proteomics data for MME Gene at MOPED

Post-translational modifications for MME Gene

  • Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
  • Myristoylation is a determinant of membrane targeting.
  • Glycosylation at Asn145, Asn285, Asn325, and Asn628
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for MME (Neprilysin/CD10)
  • Cell Signaling Technology (CST) Antibodies for MME (CD10)

Domains for MME Gene

Gene Families for MME Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Suggested Antigen Peptide Sequences for MME Gene

Graphical View of Domain Structure for InterPro Entry

P08473

UniProtKB/Swiss-Prot:

NEP_HUMAN :
  • P08473
Family:
  • Belongs to the peptidase M13 family.
genes like me logo Genes that share domains with MME: view

Function for MME Gene

Molecular function for MME Gene

GENATLAS Biochemistry: zinc metallopeptidase,membrane (neutral endopeptidase 24.11,enkephalinase),constitutively expressed in various tissues,developmentally regulated in other cell types,i.e. lymphocytes
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=55.1 uM for angiotensin-1 {ECO:0000269 PubMed:15283675}; KM=179 uM for angiotensin-2 {ECO:0000269 PubMed:15283675}; KM=111.4 uM for angiotensin 1-9 {ECO:0000269 PubMed:15283675};
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited in a dose dependent manner by opiorphin.
UniProtKB/Swiss-Prot Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Enzyme Numbers (IUBMB) for MME Gene

Gene Ontology (GO) - Molecular Function for MME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IMP 2531377
GO:0004222 metalloendopeptidase activity IMP 2521388
GO:0005515 protein binding IPI 17342744
GO:0008233 peptidase activity --
GO:0008238 exopeptidase activity IDA 6208535
genes like me logo Genes that share ontologies with MME: view
genes like me logo Genes that share phenotypes with MME: view

Animal Models for MME Gene

MGI Knock Outs for MME:

Animal Model Products

CRISPR Products

miRNA for MME Gene

miRTarBase miRNAs that target MME

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MME

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MME Gene

Localization for MME Gene

Subcellular locations from UniProtKB/Swiss-Prot for MME Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MME Gene COMPARTMENTS Subcellular localization image for MME gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20876573
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2521388
GO:0005903 brush border IDA 22272689
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with MME: view

Pathways for MME Gene

genes like me logo Genes that share pathways with MME: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEP 22272689
GO:0002003 angiotensin maturation TAS --
GO:0006508 proteolysis IDA 20876573
GO:0006518 peptide metabolic process ISS --
GO:0019233 sensory perception of pain ISS --
genes like me logo Genes that share ontologies with MME: view

Compounds for MME Gene

(1) HMDB Compounds for MME Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(8) Drugbank Compounds for MME Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
target
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
target
Candoxatril
118785-03-8 target inhibitor
Liraglutide
  • Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
204656-20-2 enzyme substrate
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
target

(1) IUPHAR Ligand for MME Gene

Ligand Type Action Affinity Pubmed IDs
thiorphan Inhibitor Inhibition

(124) Novoseek inferred chemical compound relationships for MME Gene

Compound -log(P) Hits PubMed IDs
thiorphan 93.7 74
phosphoramidon 91.6 95
racecadotril 91.3 27
candoxatril 84.4 14
ecadotril 81.3 7

(1) PharmGKB related drug/compound annotations for MME Gene

Drug/compound Annotation
"Ace Inhibitors, Plain" CA
genes like me logo Genes that share compounds with MME: view

Transcripts for MME Gene

Unigene Clusters for MME Gene

Membrane metallo-endopeptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MME

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MME

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MME Gene

No ASD Table

Relevant External Links for MME Gene

GeneLoc Exon Structure for
MME
ECgene alternative splicing isoforms for
MME

Expression for MME Gene

mRNA expression in normal human tissues for MME Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MME Gene

This gene is overexpressed in Whole Blood (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MME Gene

SOURCE GeneReport for Unigene cluster for MME Gene Hs.307734

genes like me logo Genes that share expressions with MME: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MME Gene

Orthologs for MME Gene

This gene was present in the common ancestor of animals.

Orthologs for MME Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MME 35
  • 99.6 (n)
  • 99.73 (a)
MME 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MME 35
  • 90.89 (n)
  • 90.8 (a)
MME 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MME 35
  • 91.41 (n)
  • 93.19 (a)
MME 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mme 35
  • 90.89 (n)
  • 94.13 (a)
Mme 16
Mme 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MME 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mme 35
  • 91.02 (n)
  • 94.27 (a)
chicken
(Gallus gallus)
Aves MME 35
  • 77.29 (n)
  • 78.8 (a)
MME 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MME 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nep1 36
  • 34 (a)
ManyToMany
Nep2 36
  • 32 (a)
ManyToMany
Nep4 36
  • 26 (a)
ManyToMany
CG8358 37
  • 31 (a)
BcDNA:GH07188 37
  • 25 (a)
CG4721 37
  • 24 (a)
CG14528 37
  • 25 (a)
Nep4 37
  • 35 (a)
Nep2 37
  • 35 (a)
CG14527 37
  • 25 (a)
Nep1 37
  • 41 (a)
CG6265 37
  • 45 (a)
CG14529 37
  • 24 (a)
CG5527 37
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea nep-1 36
  • 31 (a)
ManyToMany
nep-11 36
  • 30 (a)
ManyToMany
nep-2 36
  • 36 (a)
ManyToMany
T25B6.2 37
  • 23 (a)
F18A12.1 37
  • 22 (a)
F54F11.2 37
  • 27 (a)
T16A9.4 37
  • 31 (a)
F26G1.6 37
  • 29 (a)
T05A8.4 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for MME:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MME Gene

ENSEMBL:
Gene Tree for MME (if available)
TreeFam:
Gene Tree for MME (if available)

Paralogs for MME Gene

Paralogs for MME Gene

genes like me logo Genes that share paralogs with MME: view

Variants for MME Gene

Sequence variations from dbSNP and Humsavar for MME Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6665 -- 155,183,416(-) GACAC(G/T)TAAAT utr-variant-3-prime
rs12176 -- 155,180,953(+) ATTCT(A/T)ATACA utr-variant-3-prime
rs12765 -- 155,182,901(+) GTTCT(A/G)TAGAG utr-variant-3-prime
rs701109 -- 155,180,618(-) TCTAG(A/G)ACAAC utr-variant-3-prime
rs968628 -- 155,099,122(-) TAATC(C/T)CATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MME Gene

Variant ID Type Subtype PubMed ID
nsv877677 CNV Loss 21882294
nsv877678 CNV Loss 21882294
nsv829762 CNV Gain 17160897

Relevant External Links for MME Gene

HapMap Linkage Disequilibrium report
MME
Human Gene Mutation Database (HGMD)
MME

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MME Gene

Disorders for MME Gene

(4) University of Copenhagen DISEASES for MME Gene

(93) Novoseek inferred disease relationships for MME Gene

Disease -log(P) Hits PubMed IDs
lymphoblastic leukemia acute 68 41
alzheimers disease 65.6 46
lymphoma b-cell 60.1 10
sarcoma endometrial stromal 59.3 7
senile plaques 58.7 6

Relevant External Links for MME

Genetic Association Database (GAD)
MME
Human Genome Epidemiology (HuGE) Navigator
MME
genes like me logo Genes that share disorders with MME: view

No data available for UniProtKB/Swiss-Prot for MME Gene

Publications for MME Gene

  1. Asp650 is crucial for catalytic activity of neutral endopeptidase 24- 11. (PMID: 8168535) Le Moual H. … Boileau G. (Eur. J. Biochem. 1994) 3 4 23
  2. Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. (PMID: 10669592) Oefner C. … Dale G.E. (J. Mol. Biol. 2000) 3 4 23
  3. No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients. (PMID: 12527400) Lilius L. … Tjernberg L. (Neurosci. Lett. 2003) 3 23 48
  4. Association of neprilysin polymorphism with cerebral amyloid angiopathy. (PMID: 12754344) Yamada M. … Mizusawa H. (J. Neurol. Neurosurg. Psychiatr. 2003) 3 23 48
  5. Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease. (PMID: 14739539) Sakai A. … Kuroda S. (Dement Geriatr Cogn Disord 2004) 3 23 48

Products for MME Gene

  • Addgene plasmids for MME

Sources for MME Gene

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