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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MME Gene

protein-coding   GIFtS: 70
GCID: GC03P154741

Membrane Metallo-Endopeptidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane Metallo-Endopeptidase1 2     CD102 5
CALLA2 3 5     atriopeptidase2
NEP2 3 5     Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase)2
Neutral Endopeptidase1 3     Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase,
CALLA, CD10)2
enkephalinase1 2     Membrane Metallo-Endopeptidase Variant 12
neprilysin1 2     Membrane Metallo-Endopeptidase Variant 22
Common Acute Lymphocytic Leukemia Antigen2 3     Atriopeptidase3
Neutral Endopeptidase 24.112 3     EPN3
Skin Fibroblast Elastase2 3     Enkephalinase3
SFE2 3     CD10 Antigen3
EC 3.4.24.113 8     EC 3.4.248

External Ids:    HGNC: 71541   Entrez Gene: 43112   Ensembl: ENSG000001965497   OMIM: 1205205   UniProtKB: P084733   

Export aliases for MME gene to outside databases

Previous GC identifers: GC03P151792 GC03P155641 GC03P156079 GC03P156118 GC03P156280 GC03P152191


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MME Gene:
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the
diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B
phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is
found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is
present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral
endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide
hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which
encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5'
untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The
coding region is not affected by alternative splicing. (provided by RefSeq, Jul 2008)

GeneCards Summary for MME Gene: 
MME (membrane metallo-endopeptidase) is a protein-coding gene. Diseases associated with MME include chromophobe renal cell carcinoma, and pancreatic mucinous cystadenoma, and among its related super-pathways are Parkinson's disease and Metabolism of Angiotensinogen to Angiotensins. GO annotations related to this gene include endopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is PHEX.

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473
Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a
Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of
atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic
fibers

Gene Wiki entry for MME (Neprilysin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MME gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMME promoter sequence
   Search SABiosciences Chromatin IP Primers for MME

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MME


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

MME Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MME gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P154741:  view genomic region     (about GC identifiers)

Start:
154,741,913 bp from pter      End:
154,901,518 bp from pter
Size:
159,606 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473 (See protein sequence)
Recommended Name: Neprilysin  
Size: 750 amino acids; 85514 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Cell membrane; Single-pass type II membrane protein
Miscellaneous: Important cell surface marker in the diagnostic of human acute lymphocytic leukemia
Sequence caution: Sequence=CAA30157.1; Type=Erroneous initiation;
6/9 PDB 3D structures from and Proteopedia for MME (see all 9):
1DL9 (3D)        1DMT (3D)        1QVD (3D)        1R1H (3D)        1R1I (3D)        1R1J (3D)    
Secondary accessions: A8K6U6 D3DNJ9 Q3MIX4

Explore the universe of human proteins at neXtProt for MME: NX_P08473

Explore proteomics data for MME at MOPED 

Post-translational modifications:

  • UniProtKB: Myristoylation is a determinant of membrane targeting
  • UniProtKB: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08473

  • 4/20 DME Specific Peptides for MME (P08473) (see all 20)
     FPAGILQ  LNYGGIG  AYRAYQN  QNNFSLE 

    MME Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MME Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000893.2  NP_009218.2  NP_009219.2  NP_009220.2  

    ENSEMBL proteins: 
     ENSP00000420389   ENSP00000418525   ENSP00000420101   ENSP00000372450   ENSP00000419653  
     ENSP00000417079   ENSP00000353679   ENSP00000418791   ENSP00000420542   ENSP00000418238  
     ENSP00000417595  
    Reactome Protein details: P08473
    Human Recombinant Protein Products for MME: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MME (Neprilysin/CD10)
    Enzo Life Sciences proteins for MME
    OriGene Purified Proteins for MME
    OriGene Protein Over-expression Lysate for MME
    OriGene MassSpec for MME 
    OriGene Custom Protein Services for MME
    GenScript Custom Purified and Recombinant Proteins Services for MME
    Novus Biologicals MME Proteins
    Novus Biologicals MME Lysates
    Sino Biological Recombinant Protein for MME
    Sino Biological Cell Lysate for MME 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS2521388
    GO:0005903brush border IDA--
    GO:0008021synaptic vesicle ISS--

    MME for ontologies           About GeneDecksing



    MME Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MME
    R&D Systems Antibodies for MME (Neprilysin/CD10)
    Cell Signaling Technology (CST) Antibodies for MME  (CD10)
    OriGene Antibodies for MME
    OriGene Custom Antibody Services for MME
    GenScript Superior Antibodies for MME
    Novus Biologicals MME Antibodies
    Abcam antibodies for MME
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for MME
    LSBio Antibodies in human, mouse, rat for MME 

    Assay Products for MME: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MME
    R&D Systems ELISAs for MME (Neprilysin/CD10)         (see all)
    GenScript Custom Assay Services for MME
    Enzo Life Sciences assays for MME
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: Neutral endopeptidase 
    Endopeptidases

    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR000718 Peptidase_M13
     IPR018497 Peptidase_M13_C
     IPR008753 Peptidase_M13_N

    Graphical View of Domain Structure for InterPro Entry P08473

    ProtoNet protein and cluster: P08473

    2 Blocks protein domains:
    IPB000718 Neprilysin metalloprotease (M13) family signature
    IPB008753 Peptidase M13


    UniProtKB/Swiss-Prot: NEP_HUMAN, P08473
    Similarity: Belongs to the peptidase M13 family


    MME for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEP_HUMAN, P08473
    Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.
    Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a
    Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of
    atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic
    fibers
    Catalytic activity: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or
    Tyr at P1'
    Enzyme regulation: Inhibited in a dose dependent manner by opiorphin
    Biophysicochemical properties: Kinetic parameters: KM=55.1 uM for angiotensin-1; KM=179 uM for angiotensin-2;
    KM=111.4 uM for angiotensin 1-9;

         Genatlas biochemistry entry for MME:
    zinc metallopeptidase,membrane (neutral endopeptidase 24.11,enkephalinase),constitutively expressed in various
    tissues,developmentally regulated in other cell types,i.e. lymphocytes

         Enzyme Numbers (IUBMB): EC 3.4.24.111 2 EC 3.4.242

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity IMP2531377
    GO:0004222metalloendopeptidase activity IMP2521388
    GO:0005515protein binding IPI17342744
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IDA8168535
         
    MME for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mme):
     homeostasis/metabolism  immune system  integument  liver/biliary system  other 

    MME for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mmetm1Cge for MME

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MME 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MME

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MME 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MME 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MME
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MME (see all 38):
    hsa-miR-549 hsa-miR-2052 hsa-miR-579 hsa-miR-1258 hsa-miR-374a hsa-miR-218 hsa-miR-371-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMME 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MME
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MME

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MME
    Sirion Biotech Customized adenovirus for overexpression of MME

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MME (see all 25)
    OriGene ORF clones in mouse, rat for MME
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MME (NM_000902)
    Sino Biological Human cDNA Clone for MME
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MME
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MME
    Sirion Biotech Customized lentivirus for stable overexpression of MME 
                         Customized lentivirus expression plasmids for stable overexpression of MME 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MME
    Search LifeMap BioReagents cell lines for MME
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MME


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MME About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    2Renin-angiotensin system
    Renin-angiotensin system0.43
    Metabolism of Angiotensinogen to Angiotensins0.43
    3Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    4Insulin Processing
    Peptide hormone metabolism0.39
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MME
        Selected targets of ESR1

    2 R&D Systems Pathways for MME
        A-beta Uptake & Degradation
    A-beta Plaque Formation & APP Metabolism


    1 Cell Signaling Technology (CST) Pathway for MME
        Lymphocyte Signaling

    1 BioSystems Pathway for MME
        Alzheimers Disease


    3        Reactome Pathways for MME
        Metabolism of Angiotensinogen to Angiotensins
    Metabolism of proteins
    Peptide hormone metabolism

    2 PharmGKB Pathways for MME
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for MME):
        Renin-angiotensin system
    Hematopoietic cell lineage
    Protein digestion and absorption
    Alzheimer's disease


    MME for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MME

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/141 Interacting proteins for MME (P084731, 2, 3 ENSP000003536794) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081071, 3EBI-353759,EBI-629985 I2D: score=2 
    ENSG00000215328P081071, 3EBI-353759,EBI-629985 I2D: score=2 
    ENSG00000224501P081071, 3EBI-353759,EBI-629985 I2D: score=2 
    ENSG00000231555P081071, 3EBI-353759,EBI-629985 I2D: score=2 
    ENSG00000232804P081071, 3EBI-353759,EBI-629985 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEP--
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis IDA--
    GO:0006518peptide metabolic process ISS--
    GO:0019233sensory perception of pain ISS--

    MME for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MME for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for MME

    Browse Tocris compounds for MME (NEP)

    1 HMDB Compound for MME    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    8 DrugBank Compounds for MME    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Candoxatril-- 118785-03-8targetinhibitor16449355 16025254 11752352 1386491 7511759 1315825
    N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine-- --target--17139284 17016423 10592235
    N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine-- --target--17139284 17016423 10592235
    [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala-- --target--17139284 17016423 10592235
    2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM-- --target--10592235
    LiraglutideArg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37] (see all 6)204656-20-2enzymesubstrate20709939
    Phosphoramidon-- 36357-77-4targetinhibitor11752352
    Thiorphan-- 76721-89-6targetinhibitor11752352

    1 IUPHAR Ligand for MME (Neutral endopeptidase)    About this table 
    LigandTypeActionAffinityPubmed IDs
    thiorphan
    InhibitorInhibition--

    10/124 Novoseek inferred chemical compound relationships for MME gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiorphan 93.7 98 11278416 (4), 11096287 (2), 8872633 (2), 1629199 (2) (see all 65)
    phosphoramidon 91.6 122 11278416 (4), 7597662 (3), 1991995 (2), 9196090 (2) (see all 78)
    racecadotril 91.3 29 1624154 (3), 8488368 (2), 1350927 (2), 2018165 (1) (see all 23)
    candoxatril 84.4 16 9010697 (2), 18084312 (2), 8149689 (1), 8060926 (1) (see all 12)
    ecadotril 81.3 10 1847706 (2), 12370063 (1), 1662033 (1), 18689467 (1) (see all 6)
    sampatrilat 80.7 5 9535199 (1), 9797801 (1), 10371365 (1), 9535200 (1)
    omapatrilat 79.4 23 12239234 (3), 16144980 (3), 10340842 (2), 11046097 (2) (see all 14)
    candoxatrilat 76.6 8 9291201 (1), 9639376 (1), 15992061 (1), 9364744 (1) (see all 6)
    fasidotril 75.1 6 1851998 (2), 10818079 (2), 12370063 (1)
    sch 32615 72.3 4 1706428 (1), 7693075 (1), 8395264 (1)

    1 PharmGKB related drug/compound annotation for MME gene    About this table
    Drug/compound PharmGKB Annotation
    Ace Inhibitors, PlainCA  

    Search CenterWatch for drugs/clinical trials and news about MME / NEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MME gene (4 alternative transcripts): 
    NM_000902.3  NM_007287.2  NM_007288.2  NM_007289.2  

    Unigene Cluster for MME:

    Membrane metallo-endopeptidase
    Hs.307734  [show with all ESTs]
    Unigene Representative Sequence: NM_007289
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492661 ENST00000491597 ENST00000460393(uc010hvr.1 uc003fab.1 uc003fac.1 uc003fad.1 uc003fae.1)
    ENST00000481828 ENST00000382989 ENST00000462745 ENST00000493237 ENST00000360490
    ENST00000491026 ENST00000473730 ENST00000497890 ENST00000462837 ENST00000477669
    ENST00000495577 ENST00000493888
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MME
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MME (see all 38):
    hsa-miR-549 hsa-miR-2052 hsa-miR-579 hsa-miR-1258 hsa-miR-374a hsa-miR-218 hsa-miR-371-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMME 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MME
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MME
    Clone
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    OriGene clones in human, mouse for MME (see all 25)
    OriGene ORF clones in mouse, rat for MME
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MME (NM_000902)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MME
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MME
    Sirion Biotech Customized lentivirus for stable overexpression of MME 
                         Customized lentivirus expression plasmids for stable overexpression of MME 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MME
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MME
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MME
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MME

    Additional mRNA sequence: 

    AJ270689.1 AK291761.1 AK310664.1 AL833459.1 BC101632.1 BC101658.1 BC106070.1 BC143465.1 
    BX647134.1 J03779.1 KC143287.1 KC143288.1 X07166.1 Y00811.1 

    13 DOTS entries:

    DT.100782927  DT.100782926  DT.100782925  DT.118664  DT.100782923  DT.95184362  DT.91906361  DT.118665 
    DT.91973491  DT.95151001  DT.95184376  DT.40255942  DT.86849107 

    24/145 AceView cDNA sequences (see all 145):

    BU621549 AI566727 BX647134 BM462672 CK000092 AI913156 CR621123 BF476098 
    X07166 AU280506 AI671752 CB216661 BQ014191 AW408744 BG029348 Y00811 
    CF140267 BU630229 AV727403 CA424300 BU430663 BX337445 BF970996 BI869465 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MME expression in normal human tissues (normalized intensities)      MME embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTGTCTC
    MME Expression
    About this image


    MME expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Mature B-Cells Peripheral Blood
     
     Fibroblast
             Detroit 551
             Human Prostate Fibroblasts (HPrF)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 7 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Body Subcutaneous White Adipose
             Adipose-derived stem cells (Adipoplus)
             Human Preadipocyte-visceral (HPA-v)   
             Adipocyte   
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived adherent progenitor cells (MultiStem)
             HyStem+BMP4-induced MEL2 cells
     
     Dermis (Uncategorized)    fully expand to see all 5 entries
             Human Dermal Fibroblasts-adult (HDF-a)   

    See MME Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MME

    SOURCE GeneReport for Unigene cluster: Hs.307734
        SABiosciences Expression via Pathway-Focused PCR Arrays including MME: 
              Lymphoma in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MME
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MME
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MME

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MME gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mme1 , 5 membrane metallo endopeptidase1, 5 90.89(n)1
    94.13(a)1
      3 (29.97 cM)5
    173801  NM_008604.31  NP_032630.21 
     632958725 
    chicken
    (Gallus gallus)
    Aves MME1 membrane metallo-endopeptidase 77.29(n)
    78.8(a)
      425031  NM_001004412.1  NP_001004412.1 
    lizard
    (Anolis carolinensis)
    Reptilia MME6
    Uncharacterized protein
    75(a)
    1 ↔ 1
    3(16151102-16215729)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62653 endothelin-converting enzyme 45(a)
    (best of 11)
      97E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T05A8.43 protease 36(a)
    (best of 6)
      II(2717612-2725538)   --


    ENSEMBL Gene Tree for MME (if available)
    TreeFam Gene Tree for MME (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MME gene
    PHEX2  KEL2  ECE22  ECE12  MMEL12  ECEL12  
    5 SIMAP similar genes for MME using alignment to 11 protein entries:     NEP_HUMAN (see all proteins):
    MMEL1    ECE1    ECE2    PHEX    ECEL1

    MME for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2561 SNPs in MME are shown (see all 2561)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3729421521,2
    C--154795502(+) CTAAA-/AAAAAA 1 -- us2k10--------
    rs1133370991,2
    C--154795530(+) ACAAC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1413987141,2
    C--154795602(+) CTGTCA/GACTAT 1 -- us2k10--------
    rs1828690051,2
    --154795604(+) GTCGAA/CTATCA 1 -- us2k10--------
    rs1138927461,2
    C--154795647(+) AGGCAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1504328711,2
    --154795780(+) CTTGAA/GGCCAG 2 -- us2k10--------
    rs1859691881,2
    --154795813(+) ATATGA/GAGAAA 2 -- us2k10--------
    rs3761736321,2
    C--154795835(+) AAAAG-/ACCACAC 2 -- us2k10--------
    rs2008798601,2
    --154795866(+) ACACA-/CACG  
            
    CAAGC
    2 -- us2k10--------
    rs1383538471,2
    C--154796118(+) CTAAAC/TAGTGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MME (154741913 - 154901518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MME:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877678CNV Loss21882294
    nsv877677CNV Loss21882294
    nsv829762CNV Gain17160897


    Human Gene Mutation Database (HGMD): MME
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MME
    DNA2.0 Custom Variant and Variant Library Synthesis for MME

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120520    OMIM disorders: --

    20/164 diseases for MME (see all 164):    About MalaCards
    chromophobe renal cell carcinoma    pancreatic mucinous cystadenoma    eosinophilic variant of chromophobe renal cell carcinoma    atypical polypoid adenomyoma
    membranous glomerulonephritis    acute lymphocytic leukemia    acute diarrhea    translocation renal cell carcinoma
    endometrial stromal tumor    adenosarcoma    phyllode tumor    mixed epithelial stromal tumour
    cystic nephroma    ossifying fibromyxoid tumor    intravascular large b-cell lymphoma    pleomorphic rhabdomyosarcoma
    superficial basal cell carcinoma    adenofibroma    hirschsprung disease cardiac defects and autonomic dysfunction    autonomic dysfunction

    4 diseases from the University of Copenhagen DISEASES database for MME:
    Alzheimer's disease     Hypertension     Congestive heart failure     Pain agnosia

    MME for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for MME gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 68 65 1535484 (2), 2348236 (2), 2118055 (1), 1708483 (1) (see all 39)
    alzheimers disease 65.6 62 15778722 (2), 17021406 (2), 11689168 (2), 19250583 (2) (see all 36)
    lymphoma b-cell 60.1 12 9625422 (4), 16705242 (1), 14500390 (1), 17430665 (1) (see all 7)
    sarcoma endometrial stromal 59.3 9 15309019 (3), 18376386 (2), 12218209 (1), 17317938 (1)
    senile plaques 58.7 8 17591969 (2), 1708483 (1), 15892294 (1), 18393807 (1) (see all 5)
    female sexual arousal disorder 54.4 2 20412068 (1), 17070062 (1)
    cerebral amyloid angiopathy 53.8 7 17021406 (2), 12387451 (2), 17591969 (1), 12754344 (1)
    adenosarcoma 53.6 9 12218209 (6), 18469708 (1), 15571618 (1), 18941402 (1)
    stromal tumors 51.8 8 11914617 (3), 16550975 (1), 18469708 (1), 18376386 (1) (see all 5)
    nephropathy membranous 49.9 11 15464186 (3), 20185638 (1), 19827739 (1), 20110811 (1)

    Genetic Association Database (GAD): MME
    Human Genome Epidemiology (HuGE) Navigator: MME (78 documents)

    Export disorders for MME gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MME gene, integrated from 9 sources (see all 967):
    (articles sorted by number of sources associating them with MME)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined risk effects of IDE and NEP gene variants on Alzheimer disease. (PubMed id 19864659)1, 4, 9 VepsAolAoinen S....Hiltunen M. (2009)
    2. [Association of the neprilysin and apolipoprotein E g ene polymorphisms with Alzheimer's disease in Xinjiang Uygur population] (PubMed id 20376800)1, 4, 9 Zhou X.H....Luo X.M. (2010)
    3. Lack of association of neprilysin gene polymorphisms with Alzheimer's disease in a southern Chinese community. (PubMed id 19250583)1, 4, 9 Fu Y....Zhao Z.H. (2009)
    4. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. (PubMed id 15283675)1, 2, 9 Rice G.I.... Hooper N.M. (2004)
    5. Asp650 is crucial for catalytic activity of neutral endopeptidase 24- 11. (PubMed id 8168535)1, 2, 9 Le Moual H.... Boileau G. (1994)
    6. Association between neprilysin polymorphisms and sporadic Alzheimer's disease. (PubMed id 17928142)1, 4, 9 Wood L.S....Dechairo B.M. (2007)
    7. Mutation screening and association study of the neprilysin gene in sporadic Alzheimer's disease in Chinese persons. (PubMed id 15860464)1, 4, 9 Shi J....Zhao Z. (2005)
    8. Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease. (PubMed id 14739539)1, 4, 9 Sakai A....Kuroda S. (2004)
    9. Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients. (PubMed id 15548496)1, 4, 9 Helisalmi S....Soininen H. (2004)
    10. Structural analysis of neprilysin with various specific and potent inhibitors. (PubMed id 14747736)1, 2, 9 Oefner C.... Dale G.E. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4311 HGNC: 7154 AceView: MME Ensembl:ENSG00000196549 euGenes: HUgn4311
    ECgene: MME Kegg: 4311 H-InvDB: MME

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MME Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MME Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MME gene:
    Search GeneIP for patents involving MME

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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