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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MME Gene

protein-coding GIFtS: 70
GCID: GC03P154741

membrane metallo-endopeptidase

Explore 169 diseases affiliated with
MME via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Membrane Metallo-Endopeptidase¹ ²		Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase)²
CALLA¹ ² ³ ⁵		Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10)²
NEP¹ ² ³ ⁵		Membrane Metallo-Endopeptidase Variant 1²
CD10¹ ² ⁵		Membrane Metallo-Endopeptidase Variant 2²
Common Acute Lymphocytic Leukemia Antigen² ³		Neprilysin¹
Neutral Endopeptidase 24.11² ³		Atriopeptidase³
Skin Fibroblast Elastase² ³		EPN³
SFE² ³		Enkephalinase³
EC 3.4.24.11³ ⁸		CD10 Antigen³
Atriopeptidase³		Neutral Endopeptidase³
Enkephalinase³		EC 3.4.24⁸

External Ids:	HGNC: 7154¹	Entrez Gene: 4311²	Ensembl: ENSG00000196549⁷	OMIM: 120520⁵	UniProtKB: P08473³

Export aliases for MME gene to outside databases

Previous GC identifers: GC03P151792 GC03P155641 GC03P156079 GC03P156118 GC03P156280 GC03P152191

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MME:

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis

of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which

represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of

normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border

of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the

amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance

P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists

in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in

four separate mRNA transcripts. The coding region is not affected by alternative splicing. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473

Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe

bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial

natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers

Gene Wiki entry for MME (Neprilysin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MME gene promoter:
AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MME promoter sequence

Search SABiosciences Chromatin IP Primers for MME

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MME

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2 Ensembl cytogenetic band: 3q25.2 HGNC cytogenetic band: 3q25.2

MME Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MME gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P154741: view genomic region (about GC identifiers)

Start:	154,741,913 bp from pter	End:	154,901,518 bp from pter
Size:	159,606 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473 (See protein sequence)

Recommended Name: Neprilysin

Size: 750 amino acids; 85514 Da

Cofactor: Binds 1 zinc ion per subunit

Subcellular location: Cell membrane; Single-pass type II membrane protein

Miscellaneous: Important cell surface marker in the diagnostic of human acute lymphocytic leukemia

Sequence caution: Sequence=CAA30157.1; Type=Erroneous initiation;

6/9 PDB 3D structures from and Proteopedia for MME (see all 9):

1DL9 (3D)

1DMT (3D)

1QVD (3D)

1R1H (3D)

1R1I (3D)

1R1J (3D)

Secondary accessions: A8K6U6 D3DNJ9 Q3MIX4

Explore the universe of human proteins at neXtProt for MME: NX_P08473

Post-translational modifications:

Myristoylation is a determinant of membrane targeting¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08473

4/20 DME Specific Peptides for MME (P08473) (see all 20)

FPAGILQ

LNYGGIG

AYRAYQN

QNNFSLE

MME Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000893.2 NP_009218.2 NP_009219.2 NP_009220.2

ENSEMBL proteins:

ENSP00000420389 ENSP00000418525 ENSP00000420101 ENSP00000372450 ENSP00000419653

ENSP00000417079 ENSP00000353679 ENSP00000418791 ENSP00000420542 ENSP00000418238

ENSP00000417595

Reactome Protein details: P08473
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MME (Neprilysin/CD10)
	Enzo Life Sciences proteins for MME
	OriGene Purified Proteins (see all 4): MME OriGene Protein Over-expression Lysate (see all 7): MME OriGene Custom Protein Services for MME
	GenScript Custom Purified and Recombinant Proteins Services for MME
	Novus Biologicals MME Proteins Novus Biologicals MME Lysates
	Sino Biological Recombinant Protein for MME
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MME

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0005887	integral to plasma membrane	NAS	2521388
GO:0005903	brush border	IDA	--

MME for ontologies About GeneDecksing

MME Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MME
	R&D Systems Antibodies for MME (Neprilysin/CD10)
	Cell Signaling Technology (CST) Antibodies for MME (CD10)
	OriGene Antibodies (see all 3): MME OriGene Custom Antibody Services for MME
	GenScript Superior Antibodies for MME
	Novus Biologicals MME Antibodies
	Abcam antibodies for MME
	Uscn Antibodies for MME
	ThermoFisher Antibody for MME

Assay Products for MME:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MME (Neprilysin/CD10) (see all)
	GenScript Custom Assay Services for MME
	Enzo Life Sciences assays for MME
	Uscn ELISAs and CLIAs for MME

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MME for domains About GeneDecksing

4 InterPro domains/families:

IPR024079 MetalloPept_cat_dom

IPR000718 Peptidase_M13

IPR018497 Peptidase_M13_C

IPR008753 Peptidase_M13_N

Graphical View of Domain Structure for InterPro Entry P08473

ProtoNet protein and cluster: P08473

2 Blocks protein families:

IPB000718 Neprilysin metalloprotease (M13) family signature

IPB008753 Peptidase M13

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473

Similarity: Belongs to the peptidase M13 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NEP_HUMAN, P08473

Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids.

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe

bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial

natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers

Catalytic activity: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at

P1'

Enzyme regulation: Inhibited in a dose dependent manner by opiorphin

Biophysicochemical properties: Kinetic parameters: KM=55.1 uM for angiotensin-1; KM=179 uM for angiotensin-2; KM=111.4

uM for angiotensin 1-9;

Genatlas biochemistry entry for MME:

zinc metallopeptidase,membrane (neutral endopeptidase 24.11,enkephalinase),constitutively expressed in various

tissues,developmentally regulated in other cell types,i.e. lymphocytes

Enzyme Numbers (IUBMB): EC 3.4.24.11¹ ² EC 3.4.24²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MME Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MME
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MME (see all 38):
		hsa-miR-549 hsa-miR-2052 hsa-miR-579 hsa-miR-1258 hsa-miR-374a hsa-miR-218 hsa-miR-371-5p hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: MME 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MME (see all 7) OriGene shRNA RFP: MME OriGene siRNA: MME
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MME

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MME

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MME (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MME (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MME (NM_000902)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MME
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MME

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MME
		Search LifeMap BioReagents cell lines for MME

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MME

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	IMP	2531377
GO:0004222	metalloendopeptidase activity	IMP	2521388
GO:0005515	protein binding	IPI	17342744
GO:0008233	peptidase activity	--	--
GO:0008270	zinc ion binding	IDA	8168535

MME for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Mme^tm1Cge for MME
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mme):

homeostasis/metabolism

immune system

integument

liver/biliary system

other

MME for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Renin-angiotensin system

Renin-angiotensin system

1.00

Metabolism of Angiotensinogen to Angiotensins

0.48

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

ACE Inhibitor Pathway, Pharmacodynamics

1.00

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

1.00

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Alzheimer's disease

0.43

Alzheimers Disease

0.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MME

Selected targets of ESR1

1 R&D Systems Pathway for MME

A-beta Uptake & Degradation

1 Cell Signaling Technology (CST) Pathway for MME

Lymphocyte Signaling

1 BioSystems Pathway for MME

Alzheimers Disease

3 Reactome Pathways for MME

	Metabolism of Angiotensinogen to Angiotensins
	Metabolism of proteins
	Peptide hormone metabolism

2 PharmGKB Pathways for MME

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for MME):

	Renin-angiotensin system
	Hematopoietic cell lineage
	Protein digestion and absorption
	Alzheimer's disease

MME for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MME

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for MME (P08473^{1, 2, 3} ENSP00000353679⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPA1A	P08107¹^,³	EBI-353759,EBI-4404728 I2D: score=2
HSPA1B	P08107¹^,³	EBI-353759,EBI-4404728 I2D: score=2
HSPB1	P04792¹^,³	EBI-353759,EBI-352682 I2D: score=2
CD9	P21926²	MINT-8407259 MINT-8406803 MINT-8406837 MINT-8406823 MINT-8406857 MINT-8407185
HIST1H2AG	P0C0S8³	I2D: score=2

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEP	--
GO:0006508	proteolysis	IDA	--
GO:0006518	peptide metabolic process	ISS	--
GO:0019233	sensory perception of pain	ISS	--
GO:0046449	creatinine metabolic process	IMP	--

MME for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MME for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for MME

Browse Tocris compounds for MME

1 HMDB Compound for MME About this table

Compound	Synonyms	CAS #	PubMed Ids
Zinc	Zinc (see all 2)	7440-66-6	--

7 DrugBank Compounds for MME About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Candoxatril	--	118785-03-8	target	inhibitor	16449355 16025254 11752352 1386491 7511759 1315825
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine	--	--	target	--	17139284 17016423 10592235
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine	--	--	target	--	17139284 17016423 10592235
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala	--	--	target	--	17139284 17016423 10592235
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM	--	--	target	--	10592235
Phosphoramidon	--	36357-77-4	target	inhibitor	11752352
Thiorphan	--	76721-89-6	target	inhibitor	11752352

10/124 Novoseek chemical compound relationships for MME gene (see all 124) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thiorphan	93.7	98	11278416 (4), 11096287 (2), 8872633 (2), 1629199 (2) (see all 65)
phosphoramidon	91.6	122	11278416 (4), 7597662 (3), 1991995 (2), 9196090 (2) (see all 78)
racecadotril	91.3	29	1624154 (3), 8488368 (2), 1350927 (2), 2018165 (1) (see all 23)
candoxatril	84.4	16	9010697 (2), 18084312 (2), 8149689 (1), 8060926 (1) (see all 12)
ecadotril	81.3	10	1847706 (2), 12370063 (1), 1662033 (1), 18689467 (1) (see all 6)
sampatrilat	80.7	5	9535199 (1), 9797801 (1), 10371365 (1), 9535200 (1)
omapatrilat	79.4	23	12239234 (3), 16144980 (3), 10340842 (2), 11046097 (2) (see all 14)
candoxatrilat	76.6	8	9291201 (1), 9639376 (1), 15992061 (1), 9364744 (1) (see all 6)
fasidotril	75.1	6	1851998 (2), 10818079 (2), 12370063 (1)
sch 32615	72.3	4	1706428 (1), 7693075 (1), 8395264 (1)

1 PharmGKB related drug/compound annotation for MME gene

Drug/compound	PharmGKB Annotation
"Ace Inhibitors, Plain"	CA

About this table

Search CenterWatch for drugs/clinical trials and news about MME / NEP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MME gene (4 alternative transcripts):

NM_000902.3 NM_007287.2 NM_007288.2 NM_007289.2

Unigene Cluster for MME:

Membrane metallo-endopeptidase

Hs.307734 [show with all ESTs]

Unigene Representative Sequence: NM_007289

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000492661 ENST00000460393(uc010hvr.1 uc003fab.1 uc003fac.1 uc003fad.1 uc003fae.1)

ENST00000491597 ENST00000481828 ENST00000382989 ENST00000462745 ENST00000493237

ENST00000360490 ENST00000491026 ENST00000473730 ENST00000497890 ENST00000462837

ENST00000477669 ENST00000495577 ENST00000493888

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MME Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MME
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MME (see all 38):
		hsa-miR-549 hsa-miR-2052 hsa-miR-579 hsa-miR-1258 hsa-miR-374a hsa-miR-218 hsa-miR-371-5p hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: MME 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MME (see all 7) OriGene shRNA RFP: MME OriGene siRNA: MME
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MME

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MME (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MME (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MME (NM_000902)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MME
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MME

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MME Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MME
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MME
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MME

Additional cDNA sequence:

AJ270689.1 AK291761.1 AK310664.1 AL833459.1 BC101632.1 BC101658.1 BC106070.1 BC143465.1

BX647134.1 J03779.1 X07166.1 Y00811.1

13 DOTS entries:

DT.100782927 DT.100782926 DT.100782925 DT.118664 DT.100782923 DT.95184362 DT.91906361 DT.118665

DT.91973491 DT.95151001 DT.95184376 DT.40255942 DT.86849107

24/145 AceView cDNA sequences (see all 145):

CK000092 AW408744 CF140267 AU280506 X07166 AI566727 AI913156 BU430663

BU621549 BX647134 AI671752 CB216661 BM462672 BQ014191 CA424300 BX337445

CR621123 AV727403 BU630229 BG029348 BF476098 Y00811 AA449082 AU125554

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MME expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCTGTCTC

About this image

MME expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

B-cell Progenitor Cells

Selective marker (cell-identifying gene)

Blood

Blood

Blood

Blood

Blood

Blood

Proximal Tubule Cells

Kidney

Blood

Peripheral Blood

Granulocyte-Monocyte Progenitor Cells

Blood

Liver

Liver Bud

Hematopoietic Stem Cells

Blood

Kidney

Podocyte Layer

Presumptive Podocytes

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)

Bone

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

White adipocyte-like cells (Differentiation of ...)

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Definitive endoderm-like cells (A scalable, suspensi...)

See MME Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MME

SOURCE GeneReport for Unigene cluster: Hs.307734

SABiosciences Expression via Pathway-Focused PCR Arrays including MME:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MME gene from 4/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MME¹	membrane metallo-endopeptidase	77.29(n) 78.8(a)		425031 NM_001004412.1 NP_001004412.1
lizard (Anolis carolinensis)	Reptilia	MME⁶	--	75(a)	1 ↔ 1	3(16153401-16215719)
fruit fly (Drosophila melanogaster)	Insecta	CG6265³	endothelin-converting enzyme	45(a) (best of 11)		97E1 --
worm (Caenorhabditis elegans)	Secernentea	T05A8.4³	protease	36(a) (best of 6)		II(2717612-2725538) --

ENSEMBL Gene Tree for MME (if available)
TreeFam Gene Tree for MME (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MME gene

PHEX² KEL² ECE2² ECE1² MMEL1² ECEL1²

5 SIMAP similar genes for MME using alignment to 11 protein entries: NEP_HUMAN (see all proteins):

MMEL1 ECE1 ECE2 PHEX ECEL1

MME for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3836438^1,2	C,F,	--	152221360(-)	`CCCCC-/CATGGC`	1	--	int¹		4		NA NS CSA	558
rs113337099^1,2	C,	--	154795528(+)	`ACAAC-/AAAAAA`	1	--	us2k¹		1		CSA	2
rs141398714^1,2		--	154795602(+)	`CTGTCA/GACTAT`	1	--	us2k¹		0	--	--	--	--
rs182869005^1,2		--	154795604(+)	`GTCGAA/CTATCA`	1	--	us2k¹		0	--	--	--	--
rs150432871^1,2		--	154795780(+)	`CTTGAA/GGCCAG`	2	--	us2k¹		0	--	--	--	--
rs185969188^1,2		--	154795813(+)	`ATATGA/GAGAAA`	2	--	us2k¹		0	--	--	--	--
rs200879860^1,2		--	154795866(+)	`ACACA-/CACG CAAGC`	2	--	us2k¹		0	--	--	--	--
rs138353847^1,2		--	154796118(+)	`CTAAAC/TAGTGT`	4	--	us2k¹		0	--	--	--	--
rs3773907^1,2	C,F,H,	--	154796181(-)	`GGAGTG/CTGTAG`	4	--	us2k¹		5		EA NS	1890
rs55705607^1,2	C,	--	154796197(+)	`TCCTCT/AATATT`	4	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for MME (154741913 - 154901518 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MME: --
Human Gene Mutation Database (HGMD): MME

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MME for disorders           About GeneDecksing

OMIM gene information: 120520    OMIM disorders: --

20/169 diseases for MME (see all 169):    About MalaCards

acute lymphocytic leukemia lymphocytic leukemia leukemia membranous glomerulonephritis, antenatal

atypical polypoid adenomyoma neutral endopeptidase deficiency hirschsprung disease, cardiac defects, and autonomic dysfunction mixed epithelial stromal tumour

eosinophilic variant of chromophobe renal cell carcinoma cerebral amyloid angiopathy skeletal muscle regeneration smooth muscle tumor

membranous glomerulonephritis diffuse large b-cell lymphoma ossifying fibromyxoid tumor sudden infant death syndrome

chromophobe renal cell carcinoma complex regional pain syndrome age related macular degeneration renal cell carcinoma

4 diseases from the University of Copenhagen DISEASES database for MME:

Alzheimer's disease Hypertension Congestive heart failure Pain agnosia

10/93 Novoseek disease relationships for MME gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	68	65	1535484 (2), 2348236 (2), 2118055 (1), 1708483 (1) (see all 39)
alzheimers disease	65.6	62	15778722 (2), 17021406 (2), 11689168 (2), 19250583 (2) (see all 36)
lymphoma b-cell	60.1	12	9625422 (4), 16705242 (1), 14500390 (1), 17430665 (1) (see all 7)
sarcoma endometrial stromal	59.3	9	15309019 (3), 18376386 (2), 12218209 (1), 17317938 (1)
senile plaques	58.7	8	17591969 (2), 1708483 (1), 15892294 (1), 18393807 (1) (see all 5)
female sexual arousal disorder	54.4	2	20412068 (1), 17070062 (1)
cerebral amyloid angiopathy	53.8	7	17021406 (2), 12387451 (2), 17591969 (1), 12754344 (1)
adenosarcoma	53.6	9	12218209 (6), 18469708 (1), 15571618 (1), 18941402 (1)
stromal tumors	51.8	8	11914617 (3), 16550975 (1), 18469708 (1), 18376386 (1) (see all 5)
nephropathy membranous	49.9	11	15464186 (3), 20185638 (1), 19827739 (1), 20110811 (1)

Genetic Association Database (GAD): MME
Human Genome Epidemiology (HuGE) Navigator: MME (78 documents)

Export disorders for MME gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MME gene, integrated from 9 sources (see all 952):
(articles sorted by number of sources associating them with MME)

Utopia: connect your pdf to the dynamic
world of online information

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. (PubMed id 15283675)^{1, 2, 9} Rice G.I.... Hooper N.M. (2004)
Asp650 is crucial for catalytic activity of neutral endopeptidase 24- 11. (PubMed id 8168535)^{1, 2, 9} Le Moual H.... Boileau G. (1994)
Mutation screening and association study of the neprilysin gene in sporadic Alzheimer's disease in Chinese persons. (PubMed id 15860464)^{1, 4, 9} Shi J....Zhao Z. (2005)
Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease. (PubMed id 14739539)^{1, 4, 9} Sakai A....Kuroda S. (2004)
Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients. (PubMed id 15548496)^{1, 4, 9} Helisalmi S....Soininen H. (2004)
Structural analysis of neprilysin with various specific and potent inhibitors. (PubMed id 14747736)^{1, 2, 9} Oefner C.... Dale G.E. (2004)
No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients. (PubMed id 12527400)^{1, 4, 9} Lilius L....Tjernberg L. (2003)
Association of neprilysin polymorphism with cerebral amyloid angiopathy. (PubMed id 12754344)^{1, 4, 9} Yamada M....Mizusawa H. (2003)
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. (PubMed id 10669592)^{1, 2, 9} Oefner C.... Dale G.E. (2000)
Human opiorphin, a natural antinociceptive modulator of opioid- dependent pathways. (PubMed id 17101991)^{1, 2} Wisner A.... Rougeot C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4311	HGNC: 7154	AceView: MME	Ensembl:ENSG00000196549	euGenes: HUgn4311
ECgene: MME	Kegg: 4311	H-InvDB: MME

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MME	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MME	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MME gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MME gene:
Search GeneIP for patents involving MME

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MME Gene

membrane metallo-endopeptidase

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MME (Gene Symbol)
Membrane Metallo-Endopeptidase
CALLA
NEP
CD10
Common Acute Lymphocytic Leukemia Antigen
Neutral Endopeptidase 24.11
Skin Fibroblast Elastase
SFE
EC 3.4.24.11
Atriopeptidase
Enkephalinase
Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase)
Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10)
Membrane Metallo-Endopeptidase Variant 1
Membrane Metallo-Endopeptidase Variant 2
Neprilysin
Atriopeptidase
EPN
Enkephalinase
CD10 Antigen
Neutral Endopeptidase
EC 3.4.24

Lymphoblastic Leukemia Acute Childhood
LUNG TUMOR
essential hypertension
Myositis Inclusion Body
Carcinoma Basal Cell
Oncocytoma
Nephropathy Membranous
Cystic Fibrosis
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AIRWAYS DISEASE
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Metaplasia
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AIDS
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MME Gene

membrane metallo-endopeptidase

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