Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MMD2 Gene

Aliases for MMD2 Gene

  • Monocyte To Macrophage Differentiation-Associated 2 2 3
  • PAQR10 3 4 6
  • Progestin And AdipoQ Receptor Family Member 10 3 4
  • Progestin And AdipoQ Receptor Family Member X 3 4
  • Monocyte-To-Macrophage Differentiation-Associated Protein 2 3
  • Monocyte To Macrophage Differentiation Factor 2 3
  • Monocyte-To-Macrophage Differentiation Factor 2 3

External Ids for MMD2 Gene

Summaries for MMD2 Gene

Entrez Gene Summary for MMD2 Gene

  • This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for MMD2 Gene

MMD2 (Monocyte To Macrophage Differentiation-Associated 2) is a Protein Coding gene. Diseases associated with MMD2 include miyoshi muscular dystrophy 2. An important paralog of this gene is MMD.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMD2 Gene

Genomics for MMD2 Gene

Genomic Location for MMD2 Gene

Start:
4,892,245 bp from pter
End:
4,959,213 bp from pter
Size:
66,969 bases
Orientation:
Minus strand

Genomic View for MMD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMD2 Gene

Regulatory Elements for MMD2 Gene

Proteins for MMD2 Gene

  • Protein details for MMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY49-PAQRA_HUMAN
    Recommended name:
    Monocyte to macrophage differentiation factor 2
    Protein Accession:
    Q8IY49
    Secondary Accessions:
    • B5MBW4
    • Q6NVU5
    • Q6TCH0

    Protein attributes for MMD2 Gene

    Size:
    270 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMD2 Gene

Proteomics data for MMD2 Gene at MOPED

Post-translational modifications for MMD2 Gene

No Post-translational modifications

Other Protein References for MMD2 Gene

No data available for DME Specific Peptides for MMD2 Gene

Domains for MMD2 Gene

Protein Domains for MMD2 Gene

UniProtKB/Swiss-Prot:

PAQRA_HUMAN
Family:
  • Belongs to the ADIPOR family.:
    • Q8IY49
genes like me logo Genes that share domains with MMD2: view

No data available for Gene Families for MMD2 Gene

Function for MMD2 Gene

Gene Ontology (GO) - Molecular Function for MMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 21968647
genes like me logo Genes that share ontologies with MMD2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MMD2 Gene

Localization for MMD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMD2 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMD2 Gene COMPARTMENTS Subcellular localization image for MMD2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 22500632
genes like me logo Genes that share ontologies with MMD2: view

Pathways for MMD2 Gene

SuperPathways for MMD2 Gene

No Data Available

Interacting Proteins for MMD2 Gene

Gene Ontology (GO) - Biological Process for MMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 21968647
GO:0019835 cytolysis --
GO:0032880 regulation of protein localization IDA 21968647
GO:0045666 positive regulation of neuron differentiation IDA 21968647
GO:0045860 positive regulation of protein kinase activity IDA 21968647
genes like me logo Genes that share ontologies with MMD2: view

No data available for Pathways by source for MMD2 Gene

Transcripts for MMD2 Gene

Unigene Clusters for MMD2 Gene

Monocyte to macrophage differentiation-associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: - -

Relevant External Links for MMD2 Gene

GeneLoc Exon Structure for
MMD2
ECgene alternative splicing isoforms for
MMD2

Expression for MMD2 Gene

mRNA expression in normal human tissues for MMD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.1), Brain - Nucleus accumbens (basal ganglia) (6.3), Brain - Caudate (basal ganglia) (5.9), Brain - Putamen (basal ganglia) (5.3), and Brain - Amygdala (5.1).

SOURCE GeneReport for Unigene cluster for MMD2 Gene Hs.558694

mRNA Expression by UniProt/SwissProt for MMD2 Gene

Q8IY49-PAQRA_HUMAN
Tissue specificity: Shows restricted expression with highest levels in brain and testis.
genes like me logo Genes that share expressions with MMD2: view

Orthologs for MMD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMD2 36
  • 99.51 (n)
  • 100 (a)
MMD2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMD2 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmd2 36
  • 88.98 (n)
  • 96.69 (a)
Mmd2 16
Mmd2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMD2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mmd2 36
  • 88.71 (n)
  • 96.28 (a)
chicken
(Gallus gallus)
Aves MMD2 36
  • 81.71 (n)
  • 83.74 (a)
MMD2 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMD2 37
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mmd2a 36
  • 72.78 (n)
  • 74.58 (a)
mmd2a 37
  • 53 (a)
OneToMany
mmd2b 37
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4615 37
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.23 36
  • 51.09 (n)
  • 40.61 (a)
Y71G12B.23 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for MMD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMD2 Gene

ENSEMBL:
Gene Tree for MMD2 (if available)
TreeFam:
Gene Tree for MMD2 (if available)

Paralogs for MMD2 Gene

Paralogs for MMD2 Gene

Selected SIMAP similar genes for MMD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMD2: view

Variants for MMD2 Gene

Sequence variations from dbSNP and Humsavar for MMD2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs182464 -- 4,903,264(-) CCCAA(A/G)CTCTC intron-variant
rs186186 -- 4,904,920(-) cccct(C/G)tgctc intron-variant
rs190967 -- 4,895,357(+) aggcc(C/T)gagcc intron-variant
rs192741 -- 4,904,868(-) ccatc(C/T)ttcat intron-variant
rs214124 -- 4,895,405(+) ggcta(G/T)gggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMD2 Gene

Variant ID Type Subtype PubMed ID
nsv8033 CNV Loss 18304495
nsv528748 CNV Loss 19592680
nsv887389 CNV Loss 21882294
esv2659019 CNV Deletion 23128226

Relevant External Links for MMD2 Gene

HapMap Linkage Disequilibrium report
MMD2

Disorders for MMD2 Gene

Relevant External Links for MMD2

Genetic Association Database (GAD)
MMD2
Human Genome Epidemiology (HuGE) Navigator
MMD2
genes like me logo Genes that share disorders with MMD2: view

No data available for UniProtKB/Swiss-Prot for MMD2 Gene

Publications for MMD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 3 4
  3. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. (PMID: 18769639) GA^A+ez L.J. … Harrison L.C. (Mol. Med. 2008) 2 3
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for MMD2 Gene

Sources for MMD2 Gene

Back to Top

Content