MMD Gene
protein-coding GIFtS : 50
GCID: GC17 M053469
monocyte to macrophage differentiation-associated
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Aliasesfor MMD gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Monocyte To Macrophage Differentiation-Associated 1 2 MMD12 PAQR111 2 3 Macrophage Maturation-Associated2 MMA1 2 Monocyte To Macrophage Differentiation Factor2 Progestin And AdipoQ Receptor Family Member 112 3 Monocyte To Macrophage Differentiation Protein2 Progestin And AdipoQ Receptor Family Member XI2 3
Export aliases for MMD gene to outside databases Previous GC identifers: GC17M053200 GC17M055951 GC17M053812 GC17M053944 GC17M050824 GC17M048830
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Summariesfor MMD gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MMD : This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 Function : Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion(By similarity)
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Genomic Viewsfor MMD gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MMD gene promoter: HOXA9B HOXA9 TBP STAT1 Pbx1a NF-E2 p45 Meis-1b Nkx6-1 NF-E2 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for MMD Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MMD
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q MMD Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M053469: view genomic region
(about GC identifiers )
Start:
53,469,974 bp from pter
End:
53,499,353 bp from pter
Size:
29,380 bases
Orientation:
minus strand
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Proteinsfor MMD gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 (See
protein sequence )Recommended Name: Monocyte to macrophage differentiation factor Size : 238 amino acids; 27667 Da
Subcellular location : Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;Multi-pass membrane protein (By similarity)
Secondary accessions : B2R6X9 D3DTY6 Q8TAN7Explore the universe of human proteins at neXtProt for MMD: NX_Q15546 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q15546 MMD Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_036461.2 ENSEMBL proteins: ENSP00000262065 ENSP00000459202 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
MMD for ontologies About GeneDecksing MMD Antibody Products: Assay Products for MMD:
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Protein
Domains / Familiesfor MMD gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MMD for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q15546 ProtoNet protein and cluster: Q15546
1 Blocks protein family : IPB004254 Hly-III related proteins UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 Similarity : Belongs to the ADIPOR family
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Functionfor MMD gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 Function : Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion(By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMDOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for MMD Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMD Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMD
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMD
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
MMD for ontologies About GeneDecksing
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Pathways & Interactionsfor MMD gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMD STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MMD (ENSP00000262065 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0019835 cytolysis
IEA --
MMD for ontologies About GeneDecksing
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Drugs & Compoundsfor MMD gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MMD Search CenterWatch for drugs/clinical trials and news about MMD / PAQRB
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Transcriptsfor MMD gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MMD gene: NM_012329.2 Unigene Cluster for MMD:
Monocyte to macrophage differentiation-associated Hs.463483 [show with all ESTs ] Unigene Representative Sequence: NM_012329 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000262065 (uc002iui.3 ) ENST00000571578 ENST00000577038 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMDOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for MMD DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMD Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMD
Additional cDNA sequence: AK303810.1 AK312760.1 AY424289.1 BC026324.1 CR541893.1 X85750.1
12 DOTS entries : DT.114950 DT.95171140
DT.100736583 DT.108806 DT.100023776 DT.120894943 DT.95171136 DT.100666521 DT.102829831 DT.120894942 DT.95171137 DT.95171138 24/153 AceView cDNA sequences (see all 153 ):
AI380112 BE645272 CA444542 AU139768 AI093944 BQ003637 AI354926 BQ440199 T24981 AA487643 AA393883 H01216 BU187239 AI623149 CR541893 AA989371 AW628135 BE089352 AA194107 AU136438 AA715085 BM841225 BE788831 BM698091 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for MMD About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 SP1 :       -                 SP2 :       -       -   -         SP3 :                      
ECgene alternative splicing isoforms for MMD
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Expression for MMD gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MMD expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTCTGAACA
About this image MMD expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MMD Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MMD SOURCE GeneReport for Unigene cluster: Hs.463483 UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 Tissue specificity : Exhibits relatively ubiquitous expression with preferential expression in mature (in vitrodifferentiated) macrophages SABiosciences Expression via Pathway-Focused PCR Array including MMD : Lung Cancer in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMDBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MMD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MMD In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMD
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Orthologsfor MMD gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MMD gene from 7/25 species (see all 25 ) About this table
ENSEMBL Gene Tree for MMD (if available)TreeFam Gene Tree for MMD (if available)
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Paralogsfor MMD gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MMD gene MMD2 2 1 SIMAP similar gene for MMD using alignment to 2 protein entries: PAQRB_HUMAN (see all proteins ):MMD2
MMD for paralogs About GeneDecksing
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Genomic Variantsfor MMD gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MMD (53469974 - 53499353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MMD: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMD
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Disorders
/ Diseasesfor MMD gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MMD for disorders About GeneDecksing
OMIM gene information: 604467
OMIM disorders : --15 diseases for MMD : About MalaCards maple syrup urine disease isovaleric acidemia propionic acidemia multiple carboxylase deficiency cerebrovascular accident moyamoya disease homocystinuria mastitis hyperhomocysteinemia hepatitis b hyperglycemia hepatitis pneumonia tuberculosis mycobacterium tuberculosis 9 diseases from the University of Copenhagen DISEASES database for MMD :Methylmalonic acidemia Moyamoya disease Vitamin B12 deficiency Propionic acidemia Maple syrup urine disease Homocystinuria Multiple carboxylase deficiency Hyperhomocysteinemia Isovaleric acidemia Human Genome Epidemiology (HuGE) Navigator: MMD (8 documents) Export disorders for MMD gene to outside databases
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Publicationsfor MMD gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MMD gene integrated from 9 sources : (articles sorted by number of sources associating them with MMD) Utopia : connect your pdf to the dynamic world of online information
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PubMed id 16044242) 1 , 2 , 3 Tang Y.T....Funk W.D. (2005) Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. (PubMed id 7503749) 1 , 2 , 3 Rehli M.... Andreesen R. (1995) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) PAQR10 and PAQR11 mediate Ras signaling in the Golgi a pparatus. (PubMed id 21968647) 1 Jin T....Chen Y. (2012) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MMD gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MMD gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MMD gene
(According to HUGE )
About This Section --
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Specialized Databases showing MMD gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MMD Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MMD gene: Search GeneIP for patents involving MMD GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MMD gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MMD OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MMD OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MMD OriGene Protein Over-expression Lysate for MMD Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MMD OriGene 3'-UTR Clone for MMD OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MMD OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MMD Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MMD OriGene Custom Protein Services for MMD OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMD QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MMD QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MMD QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MMD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MMD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MMD
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MMD Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMD
ThermoFisher Antibodies for MMD
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MMD
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