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Aliases for MMD Gene

Aliases for MMD Gene

  • Monocyte To Macrophage Differentiation-Associated 2 3
  • PAQR11 3 4 6
  • Progestin And AdipoQ Receptor Family Member 11 3 4
  • Progestin And AdipoQ Receptor Family Member XI 3 4
  • MMD1 3 6
  • Monocyte To Macrophage Differentiation Protein 3
  • Monocyte To Macrophage Differentiation Factor 3
  • Macrophage Maturation-Associated 3
  • MMA 3

External Ids for MMD Gene

Summaries for MMD Gene

Entrez Gene Summary for MMD Gene

  • This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMD Gene

MMD (Monocyte To Macrophage Differentiation-Associated) is a Protein Coding gene. Diseases associated with MMD include methylmalonic acidemia. GO annotations related to this gene include receptor activity. An important paralog of this gene is MMD2.

UniProtKB/Swiss-Prot for MMD Gene

  • Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMD Gene

Genomics for MMD Gene

Genomic Location for MMD Gene

Start:
55,392,613 bp from pter
End:
55,421,993 bp from pter
Size:
29,381 bases
Orientation:
Minus strand

Genomic View for MMD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMD Gene

Regulatory Elements for MMD Gene

Proteins for MMD Gene

  • Protein details for MMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15546-PAQRB_HUMAN
    Recommended name:
    Monocyte to macrophage differentiation factor
    Protein Accession:
    Q15546
    Secondary Accessions:
    • B2R6X9
    • D3DTY6
    • Q8TAN7

    Protein attributes for MMD Gene

    Size:
    238 amino acids
    Molecular mass:
    27667 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MMD Gene

Proteomics data for MMD Gene at MOPED

Post-translational modifications for MMD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMD Gene

Domains for MMD Gene

Protein Domains for MMD Gene

Suggested Antigen Peptide Sequences for MMD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15546

UniProtKB/Swiss-Prot:

PAQRB_HUMAN
Family:
  • Belongs to the ADIPOR family.:
    • Q15546
genes like me logo Genes that share domains with MMD: view

No data available for Gene Families for MMD Gene

Function for MMD Gene

Molecular function for MMD Gene

UniProtKB/Swiss-Prot Function: Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.

Gene Ontology (GO) - Molecular Function for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 21968647
GO:0004872 receptor activity TAS 7503749
genes like me logo Genes that share ontologies with MMD: view

miRNA for MMD Gene

miRTarBase miRNAs that target MMD

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMD Gene

Localization for MMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMD Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMD Gene COMPARTMENTS Subcellular localization image for MMD gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 4
extracellular 2
mitochondrion 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome --
GO:0005794 Golgi apparatus IDA 21968647
GO:0005887 integral component of plasma membrane TAS 7503749
genes like me logo Genes that share ontologies with MMD: view

Pathways for MMD Gene

SuperPathways for MMD Gene

No Data Available

Interacting Proteins for MMD Gene

Gene Ontology (GO) - Biological Process for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 21968647
GO:0019835 cytolysis IEA --
GO:0032880 regulation of protein localization IDA 21968647
GO:0045666 positive regulation of neuron differentiation IDA 21968647
GO:0045860 positive regulation of protein kinase activity IDA 21968647
genes like me logo Genes that share ontologies with MMD: view

No data available for Pathways by source for MMD Gene

Transcripts for MMD Gene

mRNA/cDNA for MMD Gene

Unigene Clusters for MMD Gene

Monocyte to macrophage differentiation-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - - -
SP3:

Relevant External Links for MMD Gene

GeneLoc Exon Structure for
MMD
ECgene alternative splicing isoforms for
MMD

Expression for MMD Gene

mRNA expression in normal human tissues for MMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMD Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.3), Brain - Amygdala (4.7), Brain - Putamen (basal ganglia) (4.4), and Brain - Hippocampus (4.1).

SOURCE GeneReport for Unigene cluster for MMD Gene Hs.463483

mRNA Expression by UniProt/SwissProt for MMD Gene

Q15546-PAQRB_HUMAN
Tissue specificity: Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages.
genes like me logo Genes that share expressions with MMD: view

No data available for Protein expression for MMD Gene

Orthologs for MMD Gene

This gene was present in the common ancestor of animals.

Orthologs for MMD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMD 35
  • 100 (n)
  • 100 (a)
MMD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMD 35
  • 94.12 (n)
  • 97.48 (a)
MMD 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMD 35
  • 93.7 (n)
  • 99.16 (a)
MMD 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmd 35
  • 91.18 (n)
  • 99.16 (a)
Mmd 16
Mmd 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMD 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMD 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmd 35
  • 89.5 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves MMD 35
  • 83.83 (n)
  • 90.3 (a)
MMD 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMD 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmd 35
  • 79.01 (n)
  • 89.36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11012 35
zebrafish
(Danio rerio)
Actinopterygii mmd 35
  • 73.59 (n)
  • 81.39 (a)
mmd 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006136 35
  • 49.49 (n)
  • 43.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4615 35
  • 48.26 (n)
  • 45.65 (a)
CG4615 36
  • 33 (a)
OneToMany
CG4615 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.23 36
  • 34 (a)
OneToMany
Y71G12B.23 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MMD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMD Gene

ENSEMBL:
Gene Tree for MMD (if available)
TreeFam:
Gene Tree for MMD (if available)

Paralogs for MMD Gene

Paralogs for MMD Gene

Selected SIMAP similar genes for MMD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMD: view

Variants for MMD Gene

Sequence variations from dbSNP and Humsavar for MMD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1050750 -- 55,411,302(-) CATCG(C/T)TTCTA missense, reference, nc-transcript-variant
rs1050751 -- 55,393,498(-) CACAG(C/T)GGATA utr-variant-3-prime
rs1052525 -- 55,420,210(-) CACGT(A/C)TGTGC intron-variant
rs1131307 -- 55,407,815(-) GACAG(C/T)GGAGC missense, reference, nc-transcript-variant
rs2229671 -- 55,411,403(-) GTTCC(A/G)GCCAT synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MMD Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
esv2716056 CNV Deletion 23290073
nsv2100 CNV Loss 18451855

Relevant External Links for MMD Gene

HapMap Linkage Disequilibrium report
MMD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMD Gene

Disorders for MMD Gene

(1) MalaCards Diseases for MMD Gene

Search for MMD Gene in MalaCards »

Relevant External Links for MMD

Genetic Association Database (GAD)
MMD
Human Genome Epidemiology (HuGE) Navigator
MMD
genes like me logo Genes that share disorders with MMD: view

No data available for UniProtKB/Swiss-Prot for MMD Gene

Publications for MMD Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang Y.T. … Funk W.D. (J. Mol. Evol. 2005) 2 3 4
  2. Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. (PMID: 7503749) Rehli M. … Andreesen R. (Biochem. Biophys. Res. Commun. 1995) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MMD Gene

Sources for MMD Gene

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