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Aliases for MMD Gene

Aliases for MMD Gene

  • Monocyte To Macrophage Differentiation Associated 2 3 5
  • Progestin And AdipoQ Receptor Family Member 11 3 4
  • Progestin And AdipoQ Receptor Family Member XI 3 4
  • PAQR11 3 4
  • Monocyte To Macrophage Differentiation-Associated 2
  • Monocyte To Macrophage Differentiation Protein 3
  • Monocyte To Macrophage Differentiation Factor 3
  • Macrophage Maturation-Associated 3
  • MMD1 3
  • MMA 3

External Ids for MMD Gene

Previous GeneCards Identifiers for MMD Gene

  • GC17M053200
  • GC17M055951
  • GC17M053812
  • GC17M053944
  • GC17M050824
  • GC17M053469
  • GC17M048830

Summaries for MMD Gene

Entrez Gene Summary for MMD Gene

  • This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMD Gene

MMD (Monocyte To Macrophage Differentiation Associated) is a Protein Coding gene. Diseases associated with MMD include Amino Acid Metabolic Disorder and Sleep Disorder. GO annotations related to this gene include protein kinase activity and receptor activity. An important paralog of this gene is MMD2.

UniProtKB/Swiss-Prot for MMD Gene

  • Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.

Additional gene information for MMD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMD Gene

Genomics for MMD Gene

Regulatory Elements for MMD Gene

Enhancers for MMD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H055442 1.5 Ensembl ENCODE dbSUPER 17.5 -22.2 -22229 3 PKNOX1 ARID4B DMAP1 SLC30A9 FOS ATF7 RUNX3 PAF1 JUNB PPARG MMD LOC101927367
GH17H055449 1.6 Ensembl ENCODE dbSUPER 12.1 -30.1 -30138 4 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 REST ZNF592 MMD LOC101927367
GH17H055448 1.3 Ensembl ENCODE dbSUPER 12.1 -27.1 -27126 1 SIX4 SOX13 CEBPG RAD21 ZNF644 RFX5 GATA3 GATA2 RERE RCOR1 MMD COX11 LOC101927367
GH17H055447 1.2 ENCODE dbSUPER 12.1 -25.0 -25022 0 FOXA2 ATF1 MLX YY1 MXD4 REST PPARG KAT8 NFIL3 RCOR2 MMD LOC101927367
GH17H055454 1.2 ENCODE dbSUPER 11.5 -33.2 -33173 1 PKNOX1 FOXA2 SIN3A FEZF1 DMAP1 FOS DEK TSHZ1 PPARG KAT8 MMD STXBP4 LOC101927367
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MMD on UCSC Golden Path with GeneCards custom track

Promoters for MMD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095890 493 2200 PKNOX1 ARID4B SIN3A ZNF121 GLIS2 ATF7 PAF1 ZNF202 SP3 ZHX2

Genomic Location for MMD Gene

Chromosome:
17
Start:
55,392,613 bp from pter
End:
55,421,993 bp from pter
Size:
29,381 bases
Orientation:
Minus strand

Genomic View for MMD Gene

Genes around MMD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMD Gene

Proteins for MMD Gene

  • Protein details for MMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15546-PAQRB_HUMAN
    Recommended name:
    Monocyte to macrophage differentiation factor
    Protein Accession:
    Q15546
    Secondary Accessions:
    • B2R6X9
    • D3DTY6
    • Q8TAN7

    Protein attributes for MMD Gene

    Size:
    238 amino acids
    Molecular mass:
    27667 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MMD Gene

Post-translational modifications for MMD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMD Gene

Domains & Families for MMD Gene

Gene Families for MMD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MMD Gene

Suggested Antigen Peptide Sequences for MMD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15546

UniProtKB/Swiss-Prot:

PAQRB_HUMAN :
  • Belongs to the ADIPOR family.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with MMD: view

Function for MMD Gene

Molecular function for MMD Gene

UniProtKB/Swiss-Prot Function:
Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.

Phenotypes From GWAS Catalog for MMD Gene

Gene Ontology (GO) - Molecular Function for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 21968647
GO:0004872 receptor activity TAS 7503749
genes like me logo Genes that share ontologies with MMD: view

Phenotypes for MMD Gene

GenomeRNAi human phenotypes for MMD:
genes like me logo Genes that share phenotypes with MMD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MMD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMD Gene

Localization for MMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMD Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMD gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
lysosome 4
endosome 3
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA 21968647
GO:0005887 integral component of plasma membrane TAS 7503749
genes like me logo Genes that share ontologies with MMD: view

Pathways & Interactions for MMD Gene

No Data Available

Gene Ontology (GO) - Biological Process for MMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0019835 cytolysis IEA --
GO:0032880 regulation of protein localization IDA 21968647
GO:0045666 positive regulation of neuron differentiation IDA 21968647
GO:0045860 positive regulation of protein kinase activity IDA 21968647
genes like me logo Genes that share ontologies with MMD: view

No data available for Pathways by source and SIGNOR curated interactions for MMD Gene

Drugs & Compounds for MMD Gene

(4) Drugs for MMD Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coal tar Approved Pharma 210
Anesthetics Pharma 10074
Pharmaceutical Solutions Pharma 8574
Calamus Nutra 492
genes like me logo Genes that share compounds with MMD: view

Transcripts for MMD Gene

Unigene Clusters for MMD Gene

Monocyte to macrophage differentiation-associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MMD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MMD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - - -
SP3:

Relevant External Links for MMD Gene

GeneLoc Exon Structure for
MMD
ECgene alternative splicing isoforms for
MMD

Expression for MMD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMD Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Amygdala (x4.7), Brain - Putamen (basal ganglia) (x4.4), and Brain - Hippocampus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MMD Gene:

MMD

SOURCE GeneReport for Unigene cluster for MMD Gene:

Hs.463483

mRNA Expression by UniProt/SwissProt for MMD Gene:

Q15546-PAQRB_HUMAN
Tissue specificity: Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages.

Evidence on tissue expression from TISSUES for MMD Gene

  • Nervous system(4.9)
  • Blood(4.6)
  • Spleen(4.4)
  • Urine(2.8)
  • Liver(2.3)
  • Lung(2.2)
  • Kidney(2.1)
  • Intestine(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MMD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMD Gene

Orthologs for MMD Gene

This gene was present in the common ancestor of animals.

Orthologs for MMD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMD 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia MMD 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMD 33 34
  • 94.12 (n)
dog
(Canis familiaris)
Mammalia MMD 33 34
  • 93.7 (n)
mouse
(Mus musculus)
Mammalia Mmd 33 16 34
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Mmd 33
  • 89.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MMD 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMD 33 34
  • 83.83 (n)
lizard
(Anolis carolinensis)
Reptilia MMD 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmd 33
  • 79.01 (n)
zebrafish
(Danio rerio)
Actinopterygii mmd 33 34
  • 73.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11012 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006136 33
  • 49.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4615 33 34 35
  • 48.26 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.23 35 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for MMD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMD Gene

ENSEMBL:
Gene Tree for MMD (if available)
TreeFam:
Gene Tree for MMD (if available)

Paralogs for MMD Gene

Paralogs for MMD Gene

(1) SIMAP similar genes for MMD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMD: view

Variants for MMD Gene

Sequence variations from dbSNP and Humsavar for MMD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000054124 -- 55,401,517(+) TAGAA(A/G)AAGAG nc-transcript-variant, reference, synonymous-codon
rs1000396547 -- 55,414,770(+) CCCAC(C/T)AGTTT intron-variant
rs1000419712 -- 55,407,502(+) CATAG(C/T)ACTTC intron-variant
rs1000430907 -- 55,421,344(+) CCCAG(A/C)CTGTA intron-variant
rs1000507294 -- 55,421,247(+) CCCAC(C/T)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMD Gene

Variant ID Type Subtype PubMed ID
esv2716056 CNV deletion 23290073
esv3410565 CNV insertion 20981092
esv3640841 CNV loss 21293372
nsv2100 CNV deletion 18451855

Variation tolerance for MMD Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMD Gene

Disorders for MMD Gene

MalaCards: The human disease database

(14) MalaCards diseases for MMD Gene - From: DISEASES

Disorder Aliases PubMed IDs
amino acid metabolic disorder
  • inborn errors of amino acid metabolism
sleep disorder
  • non-organic sleep disorder
inherited metabolic disorder
  • inborn errors of metabolism
female stress incontinence
  • female urinary stress incontinence
hemopneumothorax
- elite association - COSMIC cancer census association via MalaCards
Search MMD in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMD

Genetic Association Database (GAD)
MMD
Human Genome Epidemiology (HuGE) Navigator
MMD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMD
genes like me logo Genes that share disorders with MMD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMD Gene

Publications for MMD Gene

  1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PMID: 16044242) Tang YT … Funk WD (Journal of molecular evolution 2005) 2 3 4 60
  2. Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. (PMID: 7503749) Rehli M … Andreesen R (Biochemical and biophysical research communications 1995) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer. (PMID: 24971538) Li W … He F (Biochemical and biophysical research communications 2014) 3 60
  5. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. (PMID: 21968647) Jin T … Chen Y (Cell research 2012) 3 60

Products for MMD Gene

Sources for MMD Gene

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