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MMD Gene

protein-coding   GIFtS: 50
GCID: GC17M053469

Monocyte To Macrophage Differentiation-Associated

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monocyte To Macrophage Differentiation-Associated1 2     MMA2
PAQR112 3 5     Macrophage Maturation-Associated2
Progestin And AdipoQ Receptor Family Member 112 3     Monocyte To Macrophage Differentiation Factor2
Progestin And AdipoQ Receptor Family Member XI2 3     Monocyte To Macrophage Differentiation Protein2
MMD12 5     

External Ids:    HGNC: 71531   Entrez Gene: 235312   Ensembl: ENSG000001089607   OMIM: 6044675   UniProtKB: Q155463   

Export aliases for MMD gene to outside databases

Previous GC identifers: GC17M053200 GC17M055951 GC17M053812 GC17M053944 GC17M050824 GC17M048830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MMD Gene:
This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although
sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein
receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an
ion channel protein in maturing macrophages. (provided by RefSeq, Jul 2008)

GeneCards Summary for MMD Gene:
MMD (monocyte to macrophage differentiation-associated) is a protein-coding gene. Diseases associated with MMD include isovaleric acidemia, and multiple carboxylase deficiency. GO annotations related to this gene include receptor activity. An important paralog of this gene is MMD2.

UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546
Function: Involved in the dynamics of lysosomal membranes associated with microglial activation following brain
lesion (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MMD gene promoter:
         HOXA9B   HOXA9   TBP   STAT1   Pbx1a   NF-E2 p45   Meis-1b   Nkx6-1   NF-E2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMMD promoter sequence
   Search Chromatin IP Primers for MMD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MMD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q

MMD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MMD gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M053469:  view genomic region     (about GC identifiers)

Start:
53,469,974 bp from pter      End:
53,499,353 bp from pter
Size:
29,380 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546 (See protein sequence)
Recommended Name: Monocyte to macrophage differentiation factor  
Size: 238 amino acids; 27667 Da
Secondary accessions: B2R6X9 D3DTY6 Q8TAN7

Explore the universe of human proteins at neXtProt for MMD: NX_Q15546

Explore proteomics data for MMD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MMD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036461.2  
    ENSEMBL proteins: 
     ENSP00000262065   ENSP00000459202  

    MMD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MMD Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MMD Antibody Products:

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    Abcam antibodies for MMD
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MMD
    Search LSBio for Antibodies for MMD

    MMD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MMD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MMD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005744 HylIII
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q15546

    ProtoNet protein and cluster: Q15546

    1 Blocks protein domain: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546
    Similarity: Belongs to the ADIPOR family


    MMD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAQRB_HUMAN, Q15546
    Function: Involved in the dynamics of lysosomal membranes associated with microglial activation following brain
    lesion (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7503749
         
    MMD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MMD
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MMD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MMD

    miRNA
    Products:
        
    miRTarBase miRNAs that target MMD:
    hsa-mir-1 (MIRT002814), hsa-mir-26b-5p (MIRT029369), hsa-mir-335-5p (MIRT017756)

    Block miRNA regulation of human, mouse, rat MMD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMD (see all 68):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-30a hsa-miR-4325 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMMD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MMD
    Predesigned siRNA for gene silencing in human, mouse, rat MMD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MMD

    Clone
    Products:
         
    OriGene clones in human, mouse for MMD (see all 7)
    OriGene ORF clones in mouse, rat for MMD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MMD
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMD

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MMD
    Browse ESI BIO Cell Lines and PureStem Progenitors for MMD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAQRB_HUMAN, Q15546: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;
    Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane4
    extracellular2
    mitochondrion2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005887integral component of plasma membrane TAS7503749
    GO:0016020membrane TAS7503749
    GO:0016021integral component of membrane ----
    GO:0031902late endosome membrane IEA--

    MMD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MMD: 
              Lung Cancer in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MMD

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MMD (ENSP000002620654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019835cytolysis IEA--

    MMD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MMD (PAQRB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MMD gene: 
    NM_012329.2  

    Unigene Cluster for MMD:

    Monocyte to macrophage differentiation-associated
    Hs.463483  [show with all ESTs]
    Unigene Representative Sequence: NM_012329
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262065(uc002iui.3) ENST00000571578 ENST00000577038
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MMD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MMD (see all 68):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-30a hsa-miR-4325 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMMD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MMD
    Predesigned siRNA for gene silencing in human, mouse, rat MMD
    Clone
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    OriGene clones in human, mouse for MMD (see all 7)
    OriGene ORF clones in mouse, rat for MMD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MMD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MMD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MMD
    OriGene qSTAR qPCR primer pairs in human, mouse for MMD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMD
      QuantiTect SYBR Green Assays in human, mouse, rat MMD
      QuantiFast Probe-based Assays in human, mouse, rat MMD

    Additional mRNA sequence: 

    AK303810.1 AK312760.1 AY424289.1 BC026324.1 CR541893.1 X85750.1 

    12 DOTS entries:

    DT.114950  DT.95171140  DT.100736583  DT.108806  DT.100023776  DT.120894943  DT.95171136  DT.100666521 
    DT.102829831  DT.120894942  DT.95171137  DT.95171138 

    Selected AceView cDNA sequences (see all 153):

    AA715085 T24981 AU136438 AW628135 CR541893 AA393883 AA487643 BU187239 
    AA194107 AU139768 AA989371 BQ440199 CA444542 AI093944 BE645272 H01216 
    BE089352 AI354926 AI380112 AI623149 BQ003637 AU138977 AA775451 AA777845 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MMD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                    -                                             
    SP2:                    -                 -     -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for MMD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MMD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTGAACA
    MMD Expression
    About this image


    MMD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Rib
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    MMD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MMD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463483

    UniProtKB/Swiss-Prot: PAQRB_HUMAN, Q15546
    Tissue specificity: Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro
    differentiated) macrophages

        Pathway & Disease-focused RT2 Profiler PCR Array including MMD: 
              Lung Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MMD
    OriGene qSTAR qPCR primer pairs in human, mouse for MMD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MMD
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    QuantiFast Probe-based Assays in human, mouse, rat MMD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MMD gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mmd1 , 5 monocyte to macrophage differentiation-associated1, 5 91.18(n)1
    99.16(a)1
      11 (54.89 cM)5
    674681  NM_026178.21  NP_080454.11 
     901876845 
    chicken
    (Gallus gallus)
    Aves MMD1 monocyte to macrophage differentiation-associated 83.83(n)
    90.3(a)
      417397  NM_001030704.1  NP_001025875.1 
    lizard
    (Anolis carolinensis)
    Reptilia MMD6
    monocyte to macrophage differentiation-associated
    85(a)
    1 ↔ 1
    GL344189.1(13995-29085)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mmd1 monocyte to macrophage differentiation-associated 79.01(n)
    89.36(a)
      100101788  XM_002937811.2  XP_002937857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mmd1 monocyte to macrophage differentiation-associated 73.59(n)
    81.39(a)
      641478  NM_001037419.1  NP_001032496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46151 , 3 CG46151 41(a)3
    48.26(n)1
    45.65(a)1
      6F53
    316561  NM_132154.31  NP_572382.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.233   -- 39(a)   I(1670209-1676431)   --


    ENSEMBL Gene Tree for MMD (if available)
    TreeFam Gene Tree for MMD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MMD gene
    MMD22  
    1 SIMAP similar gene for MMD using alignment to 2 protein entries:     PAQRB_HUMAN (see all proteins):
    MMD2

    MMD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MMD (see all 620)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851203341,2
    --53469514(+) TTTTTA/TATTTG 1 -- ds50010--------
    rs72208991,2
    C,F,A,H--53469523(+) TGTTTT/CTGCTG 1 -- ds500123Minor allele frequency- C:0.30NA NS EA WA CSA 1353
    rs739932381,2
    C,F--53469622(+) CAGTTG/AAACTT 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1908199241,2
    --53469637(+) GGCCCC/TGGTTT 1 -- ds50010--------
    rs1511874151,2
    --53469717(+) TGTCTA/GGTTGG 1 -- ds50010--------
    rs1818549551,2
    --53469749(+) CAGTCC/GTATAG 1 -- ds50010--------
    rs354061261,2
    C--53469752(+) TCCTAC/TAGAAT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1839157131,2
    --53469814(+) AAAACC/TTGAAA 1 -- ds50010--------
    rs1883433851,2
    --53469921(+) AAGTTC/TTAAGT 1 -- ds50010--------
    rs1807656401,2
    C--53469942(+) ATTCAC/TTTTTC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MMD (53469974 - 53499353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MMD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716056CNV Deletion23290073
    nsv2100CNV Loss18451855
    nsv908620CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MMD
    DNA2.0 Custom Variant and Variant Library Synthesis for MMD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604467    OMIM disorders: --

    18 diseases for MMD:    
    About MalaCards
    isovaleric acidemia    multiple carboxylase deficiency    propionic acidemia    vitamin b12 deficiency
    maple syrup urine disease    methylmalonic acidemia    moyamoya disease    mastitis
    homocystinuria    hyperhomocysteinemia    hyperglycemia    pneumonia
    hepatitis b    tuberculosis    lung cancer    hepatitis
    obesity    malaria

    7 diseases from the University of Copenhagen DISEASES database for MMD:
    Moyamoya disease     Methylmalonic acidemia     Vitamin B12 deficiency     Propionic acidemia
    Maple syrup urine disease     Homocystinuria     Hyperhomocysteinemia

    MMD for disorders           About GeneDecksing

    Genetic Association Database (GAD): MMD
    Human Genome Epidemiology (HuGE) Navigator: MMD (8 documents)

    Export disorders for MMD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MMD gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with MMD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. (PubMed id 16044242)1, 2, 3 Tang Y.T....Funk W.D. (J. Mol. Evol. 2005)
    2. Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. (PubMed id 7503749)1, 2, 3 Rehli M.... Andreesen R. (Biochem. Biophys. Res. Commun. 1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PubMed id 22021425)4 Carty C.L....Kooperberg C. (Hum. Mol. Genet. 2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. (PubMed id 21968647)1 Jin T....Chen Y. (Cell Res. 2012)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23531 HGNC: 7153 AceView: MMD Ensembl:ENSG00000108960 euGenes: HUgn23531
    ECgene: MMD H-InvDB: MMD

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MMD Pharmacogenomics, SNPs, Pathways

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