MMACHC Gene
protein-coding GIFtS: 53
GCID: GC01P045965
|
|
methylmalonic aciduria (cobalamin deficiency) cblC type,...
| |
Aliases
for MMACHC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methylmalonic Aciduria (Cobalamin Deficiency) CblC Type, WithHomocystinuria1 2 | | CblC1 | | DKFZP564I1221 | | RP11-291L19.32 | | Methylmalonic Aciduria And Homocystinuria Type C Protein2 |
Export aliases for MMACHC gene to outside databasesPrevious GC identifers: GC01P045636 GC01P045733 GC01P044077 |
Summaries
for MMACHC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MMACHC:
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity toTonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulatedthat this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this geneare associated with methylmalonic aciduria and homocystinuria type cblC. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1Function: May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12)
Gene Wiki entry for MMACHC
|
Genomic Views
for MMACHC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MMACHC gene promoter:
SRF C/EBPbeta SRF (504 AA) E47 MZF-1 ARP-1 ZID Msx-1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MMACHC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMACHC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1MMACHC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P045965: view genomic region
(about GC identifiers)
Start:
|
45,965,725 bp from pter |
End:
|
45,976,739 bp from pter |
Size:
|
11,015 bases |
Orientation:
|
plus strand |
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Proteins
for MMACHC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1 (See
protein sequence)Recommended Name: Methylmalonic aciduria and homocystinuria type C protein Size: 282 amino acids; 31728 Da
Sequence caution: Sequence=AAH06122.3; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for MMACHC:3SBY (3D)
3SBZ (3D)
3SC0 (3D)
3SOM (3D)
Secondary accessions: Q5T157 Q9BRQ7Explore the universe of human proteins at neXtProt for MMACHC: NX_Q9Y4U1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4U1
MMACHC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056321.2
ENSEMBL proteins: ENSP00000383840 ENSP00000435318
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
MMACHC for ontologies About GeneDecksing
MMACHC Antibody Products:
Assay Products for MMACHC: |
Protein
Domains /
Families
for MMACHC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y4U1 UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1Similarity: Belongs to the MMACHC family |
Function
for MMACHC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1Function: May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMACHC
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMACHC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031419 | cobalamin binding |
IEA | -- |
MMACHC for ontologies About GeneDecksing
|
Pathways & Interactions
for MMACHC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Vitamin digestion and absorption | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for MMACHC):
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis
MMACHC for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MMACHC
1 Interacting protein for MMACHC (Q9Y4U13) via UniProtKB, MINT, STRING, and/or I2D
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009236 | cobalamin biosynthetic process |
IEA | -- |
MMACHC for ontologies About GeneDecksing
|
Drugs & Compounds
for MMACHC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MMACHC for compounds About GeneDecksing
 Browse Tocris compounds for MMACHC
3 HMDB Compounds for MMACHC About this table
2 DrugBank Compounds for MMACHC About this table
2 Novoseek chemical compound relationships for MMACHC gene About this table
Search CenterWatch for drugs/clinical trials and news about MMACHC / MMAC
|
Transcripts
for MMACHC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MMACHC gene: NM_015506.2 Unigene Cluster for MMACHC: Methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria Hs.13024 [show with all ESTs]Unigene Representative Sequence: NM_0155063 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000401061(uc009vxv.3) ENST00000474382 ENST00000477188
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMACHC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMACHC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MMACHC (NM_015506) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MMACHC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMACHC |
Additional cDNA sequence: AK098537.1 5 DOTS entries: DT.100748621 DT.412704 DT.100748619 DT.95364791 DT.121402044 24/94 AceView cDNA sequences (see all 94): BC006122 BM662145 BX280986 BX280879 AA758260 BU729469 AW580402 BM980565 BM702997 CD358853 AA721996 BU839693 BU632364 BU192363 BQ706536 BF988085 AI138764 AW136517 AL080062 CA427378 BU597105 AK098537 BE048794 BF990978
GeneLoc Exon Structure
|
Expression
for MMACHC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MMACHC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCACTCT
About this image
See MMACHC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MMACHC
SOURCE GeneReport for Unigene cluster: Hs.13024
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1Tissue specificity: Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node,thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes
SABiosciences Custom PCR Arrays for MMACHC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMACHC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MMACHC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMACHC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMACHC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MMACHC |
Orthologs
for MMACHC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MMACHC gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mmachc1 , 5 |
methylmalonic aciduria cblC type, with homocystinuria1, 5 |
83.99(n)1
84.95(a)1 |
|
4 (53.29 cM)5
670961 NM_025962.31 NP_080238.21
1167022795 |
chicken
(Gallus gallus) |
Aves |
MMACHC1 |
methylmalonic aciduria (cobalamin deficiency) cblC more |
63.59(n)
60.92(a) |
|
424597 NM_001031281.1 NP_001026452.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MMACHC6 |
-- |
61(a) |
1 ↔ 1 |
4(110417085-110420833) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.146562 |
Transcribed sequence with weak similarity to protein more |
75.07(n) |
|
142029689 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc29d042 |
Transcribed sequence with weak similarity to protein more |
75.35(n) |
|
BI979299.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
cblc-11 |
Protein CBLC-1 |
47.6(n)
38.6(a) |
|
3565644 NM_001027353.3 NP_001022524.1 |
ENSEMBL Gene Tree for MMACHC (if available)
TreeFam Gene Tree for MMACHC (if available) |
Paralogs
for MMACHC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MMACHC gene
MMACHC for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MMACHC
PGOHUM00000237865
|
Genomic Variants
for MMACHC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MMACHC (45965725 - 45976739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MMACHC: --
Human Gene Mutation Database (HGMD): MMACHC
Locus Specific Mutation Databases (LSDB): MMACHC
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMACHC |
|
Disorders
/ Diseases
for MMACHC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MMACHC for disorders About GeneDecksing
OMIM gene information: 609831
OMIM disorders: 277400
UniProtKB/Swiss-Prot: MMAC_HUMAN, Q9Y4U1
Defects in MMACHC are the cause of methylmalonic aciduria and homocystinuria type cblC (MMAHCC) [MIM:277400].A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) andmethylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic,ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, someindividuals develop symptoms in adulthood
9  diseases for MMACHC: About MalaCardsmethylmalonic aciduria and homocystinuria cblc methylmalonic aciduria and homocystinuria type cblc homocystinuria
disorders of intracellular cobalamin metabolism methylmalonic acidemia homocysteinemia hepatitis b
hepatitis
3 diseases from the University of Copenhagen DISEASES database for MMACHC:Methylmalonic acidemia Homocystinuria Megaloblastic anemia GeneTests: MMACHC
Disorders of Intracellular Cobalamin Metabolism
Human Genome Epidemiology (HuGE) Navigator: MMACHC (5 documents)
Export disorders for MMACHC gene to outside databases
|
Publications
for MMACHC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MMACHC gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with MMACHC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. (PubMed id 16311595)1, 2, 3, 7, 9 Lerner-Ellis J.P.... Rosenblatt D.S. (2006)
- Late-onset cobalamin-C disorder: a challenging diagnosis. (PubMed id 17431913)1, 7, 9 Ben-Omran T.I....Feigenbaum A. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence. (PubMed id 19200761)1, 9 Loewy A.D....Rosenblatt D.S. (2009)
- Mechanism of vitamin B12-responsiveness in cblC methy lmalonic aciduria with homocystinuria. (PubMed id 19700356)1, 9 Froese D.S....Gravel R.A. (2009)
- Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype-phenotype correlations. (PubMed id 19370762)1, 9 Lerner-Ellis J.P....Fowler B. (2009)
- [Mutation analysis of the MMACHC gene in a pedigree with methylmalonic aciduria] (PubMed id 19199254)1, 9 Tang H....Zhou T.H. (2009)
- Processing of alkylcobalamins in mammalian cells: A r ole for the MMACHC (cblC) gene product. (PubMed id 19447654)1, 9 Hannibal L....Jacobsen D.W. (2009)
- Spectrum of MMACHC mutations in Italian and Portuguese patients with combined methylmalonic aciduria and homocystinuria, cblC type. (PubMed id 18164228)1, 9 Nogueira C....Dionisi-Vici C. (2008)
|
External Searches for MMACHC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MMACHC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MMACHC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MMACHC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MMACHC | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MMACHC |
|
| | |
About This Section
| Patent Information for MMACHC gene:
Search GeneIP for patents involving MMACHC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MMACHC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MMACHC | | OriGene shRNA RFP for MMACHC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MMACHC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MMACHC | | | OriGene Protein Over-expression Lysate for MMACHC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MMACHC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MMACHC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MMACHC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MMACHC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MMACHC | | OriGene Custom Protein Services for MMACHC | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MMACHC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MMACHC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MMACHC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MMACHC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MMACHC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MMACHC |
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| |  |  |  |  | | | | | | Recombinant Protein for MMACHC |
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 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MMACHC |
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