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Aliases for MLXIP Gene

Aliases for MLXIP Gene

  • MLX Interacting Protein 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 36 3 4
  • Transcriptional Activator MondoA 3 4
  • BHLHe36 3 4
  • MONDOA 3 4
  • MIR 3 4
  • Mlx Interactor 3
  • KIAA0867 4

External Ids for MLXIP Gene

Previous GeneCards Identifiers for MLXIP Gene

  • GC12P121137
  • GC12P121002
  • GC12P122516
  • GC12P119572

Summaries for MLXIP Gene

Entrez Gene Summary for MLXIP Gene

  • This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

GeneCards Summary for MLXIP Gene

MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Translation Insulin regulation of translation and Alzheimer's disease. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MLX.

UniProtKB/Swiss-Prot for MLXIP Gene

  • Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLXIP Gene

Genomics for MLXIP Gene

Regulatory Elements for MLXIP Gene

Enhancers for MLXIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MLXIP on UCSC Golden Path with GeneCards custom track

Promoters for MLXIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MLXIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MLXIP Gene

122,078,722 bp from pter
122,147,347 bp from pter
68,626 bases
Plus strand

Genomic View for MLXIP Gene

Genes around MLXIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLXIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLXIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLXIP Gene

Proteins for MLXIP Gene

  • Protein details for MLXIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MLX-interacting protein
    Protein Accession:
    Secondary Accessions:
    • A7MBN0
    • O94945
    • Q7LC47
    • Q8IXP1
    • Q8TAH9
    • Q8WVQ0
    • Q8WYA5

    Protein attributes for MLXIP Gene

    919 amino acids
    Molecular mass:
    101185 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.
    • Sequence=BAA74890.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MLXIP Gene


neXtProt entry for MLXIP Gene

Proteomics data for MLXIP Gene at MOPED

Post-translational modifications for MLXIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLXIP Gene

No data available for DME Specific Peptides for MLXIP Gene

Domains & Families for MLXIP Gene

Gene Families for MLXIP Gene

Protein Domains for MLXIP Gene

Suggested Antigen Peptide Sequences for MLXIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MLXIP: view

Function for MLXIP Gene

Molecular function for MLXIP Gene

UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Gene Ontology (GO) - Molecular Function for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with MLXIP: view
genes like me logo Genes that share phenotypes with MLXIP: view

Animal Model Products

miRNA for MLXIP Gene

miRTarBase miRNAs that target MLXIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLXIP Gene

Localization for MLXIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLXIP Gene

Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250 UniProtKB:Q2VPU4, ECO:0000269 PubMed:12446771, ECO:0000269 PubMed:16782875}.

Subcellular locations from

Jensen Localization Image for MLXIP Gene COMPARTMENTS Subcellular localization image for MLXIP gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MLXIP Gene

Pathways & Interactions for MLXIP Gene

genes like me logo Genes that share pathways with MLXIP: view

Pathways by source for MLXIP Gene

Interacting Proteins for MLXIP Gene

Gene Ontology (GO) - Biological Process for MLXIP Gene


No data available for SIGNOR curated interactions for MLXIP Gene

Drugs & Compounds for MLXIP Gene

No Compound Related Data Available

Transcripts for MLXIP Gene

Unigene Clusters for MLXIP Gene

MLX interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLXIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP6: -

Relevant External Links for MLXIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLXIP Gene

mRNA expression in normal human tissues for MLXIP Gene

mRNA differential expression in normal tissues according to GTEx for MLXIP Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for MLXIP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLXIP Gene

SOURCE GeneReport for Unigene cluster for MLXIP Gene Hs.721711

mRNA Expression by UniProt/SwissProt for MLXIP Gene

Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle.
genes like me logo Genes that share expression patterns with MLXIP: view

Protein tissue co-expression partners for MLXIP Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MLXIP Gene

Orthologs for MLXIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MLXIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MLXIP 35
  • 87.59 (n)
  • 88.1 (a)
  • 87 (a)
(Canis familiaris)
Mammalia MLXIP 35
  • 87.41 (n)
  • 90.07 (a)
  • 90 (a)
(Mus musculus)
Mammalia Mlxip 35
  • 85.24 (n)
  • 88.02 (a)
Mlxip 16
Mlxip 36
  • 87 (a)
(Pan troglodytes)
Mammalia MLXIP 35
  • 99.24 (n)
  • 99.11 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mlxip 35
  • 85.33 (n)
  • 87.13 (a)
(Monodelphis domestica)
Mammalia MLXIP 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MLXIP 36
  • 74 (a)
(Gallus gallus)
Aves MLXIP 35
  • 66.41 (n)
  • 67.57 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia MLXIP 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mlxip 35
  • 64.56 (n)
  • 64.44 (a)
Str.4943 35
(Danio rerio)
Actinopterygii mlxip 35
  • 61.94 (n)
  • 61.01 (a)
mlxip 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6592 35
fruit fly
(Drosophila melanogaster)
Insecta Mio 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea mml-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for MLXIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLXIP Gene

Gene Tree for MLXIP (if available)
Gene Tree for MLXIP (if available)

Paralogs for MLXIP Gene

Paralogs for MLXIP Gene

(1) SIMAP similar genes for MLXIP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MLXIP: view

Variants for MLXIP Gene

Sequence variations from dbSNP and Humsavar for MLXIP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7978353 - 122,133,442(+) GGATG(A/G/T)GCAGG nc-transcript-variant, reference, missense
rs34702867 - 122,133,870(+) CTTTT(G/T)TGCAC nc-transcript-variant, reference, missense
rs2017594 -- 122,146,661(-) GAAGT(A/C)AACAC utr-variant-3-prime
rs10846525 -- 122,134,419(+) TGGAG(C/T)GCAGT intron-variant
rs10847611 -- 122,128,078(+) TGCAG(C/G)GCCTG intron-variant, upstream-variant-2KB

Variation tolerance for MLXIP Gene

Gene Damage Index Score: 6.65; 78.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MLXIP Gene

Disorders for MLXIP Gene

Relevant External Links for MLXIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MLXIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLXIP Gene

Publications for MLXIP Gene

  1. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin A.N. … Ayer D.E. (Mol. Cell. Biol. 2000) 2 3 4 67
  2. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PMID: 19706488) Kaadige M.R. … Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PMID: 18458340) Stoltzman C.A. … Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  5. C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study. (PMID: 25179879) Ghasemi A. … Seifi M. (Anatol J Cardiol 2015) 3

Products for MLXIP Gene

Sources for MLXIP Gene