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Aliases for MLXIP Gene

Aliases for MLXIP Gene

  • MLX Interacting Protein 2 3
  • MONDOA 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 36 3 4
  • Transcriptional Activator MondoA 3 4
  • KIAA0867 4 6
  • BHLHe36 3 4
  • MIR 3 4
  • MLX-Interacting Protein 3
  • Mlx Interactor 3

External Ids for MLXIP Gene

Previous GeneCards Identifiers for MLXIP Gene

  • GC12P121137
  • GC12P121002
  • GC12P122516
  • GC12P119572

Summaries for MLXIP Gene

Entrez Gene Summary for MLXIP Gene

  • This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

GeneCards Summary for MLXIP Gene

MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MLX.

UniProtKB/Swiss-Prot for MLXIP Gene

  • Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLXIP Gene

Genomics for MLXIP Gene

Regulatory Elements for MLXIP Gene

Genomic Location for MLXIP Gene

122,078,722 bp from pter
122,147,347 bp from pter
68,626 bases
Plus strand

Genomic View for MLXIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLXIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLXIP Gene

Proteins for MLXIP Gene

  • Protein details for MLXIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MLX-interacting protein
    Protein Accession:
    Secondary Accessions:
    • A7MBN0
    • O94945
    • Q7LC47
    • Q8IXP1
    • Q8TAH9
    • Q8WVQ0
    • Q8WYA5

    Protein attributes for MLXIP Gene

    919 amino acids
    Molecular mass:
    101185 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.
    • Sequence=BAA74890.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MLXIP Gene


neXtProt entry for MLXIP Gene

Proteomics data for MLXIP Gene at MOPED

Post-translational modifications for MLXIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLXIP Gene

No data available for DME Specific Peptides for MLXIP Gene

Domains for MLXIP Gene

Gene Families for MLXIP Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for MLXIP Gene

Suggested Antigen Peptide Sequences for MLXIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HAP2
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MLXIP: view

Function for MLXIP Gene

Molecular function for MLXIP Gene

UniProtKB/Swiss-Prot Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Gene Ontology (GO) - Molecular Function for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MLXIP: view

Phenotypes for MLXIP Gene

GenomeRNAi human phenotypes for MLXIP:
genes like me logo Genes that share phenotypes with MLXIP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLXIP Gene

Localization for MLXIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLXIP Gene

Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250 UniProtKB:Q2VPU4, ECO:0000269 PubMed:12446771, ECO:0000269 PubMed:16782875}.

Subcellular locations from

Jensen Localization Image for MLXIP Gene COMPARTMENTS Subcellular localization image for MLXIP gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with MLXIP: view

Pathways for MLXIP Gene

genes like me logo Genes that share pathways with MLXIP: view

Pathways by source for MLXIP Gene

1 KEGG pathway for MLXIP Gene

Interacting Proteins for MLXIP Gene

Gene Ontology (GO) - Biological Process for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006913 nucleocytoplasmic transport IEA --
GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter IMP 16782875
genes like me logo Genes that share ontologies with MLXIP: view

Transcripts for MLXIP Gene

Unigene Clusters for MLXIP Gene

MLX interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLXIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP6: -

Relevant External Links for MLXIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLXIP Gene

mRNA expression in normal human tissues for MLXIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MLXIP Gene

This gene is overexpressed in Muscle - Skeletal (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLXIP Gene

SOURCE GeneReport for Unigene cluster for MLXIP Gene Hs.721711

mRNA Expression by UniProt/SwissProt for MLXIP Gene

Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle.
genes like me logo Genes that share expressions with MLXIP: view

Orthologs for MLXIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MLXIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MLXIP 35
  • 99.24 (n)
  • 99.11 (a)
  • 100 (a)
(Bos Taurus)
Mammalia MLXIP 35
  • 87.59 (n)
  • 88.1 (a)
  • 87 (a)
(Canis familiaris)
Mammalia MLXIP 35
  • 87.41 (n)
  • 90.07 (a)
  • 90 (a)
(Mus musculus)
Mammalia Mlxip 35
  • 85.24 (n)
  • 88.02 (a)
Mlxip 16
Mlxip 36
  • 87 (a)
(Monodelphis domestica)
Mammalia MLXIP 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MLXIP 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Mlxip 35
  • 85.33 (n)
  • 87.13 (a)
(Gallus gallus)
Aves MLXIP 35
  • 66.41 (n)
  • 67.57 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia MLXIP 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mlxip 35
  • 64.56 (n)
  • 64.44 (a)
Str.4943 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6592 35
(Danio rerio)
Actinopterygii mlxip 35
  • 61.94 (n)
  • 61.01 (a)
mlxip 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mio 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea mml-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for MLXIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLXIP Gene

Gene Tree for MLXIP (if available)
Gene Tree for MLXIP (if available)

Paralogs for MLXIP Gene

Paralogs for MLXIP Gene

Selected SIMAP similar genes for MLXIP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MLXIP: view

Variants for MLXIP Gene

Sequence variations from dbSNP and Humsavar for MLXIP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs709284 -- 122,147,205(-) CGTGG(A/G)CCGGA utr-variant-3-prime
rs1043763 -- 122,146,362(+) TGTGA(A/G)GGACA utr-variant-3-prime
rs1043764 -- 122,146,368(+) GGACA(C/G/T)GCATG utr-variant-3-prime
rs1043771 -- 122,146,934(+) GCCAT(C/T)CCCTA utr-variant-3-prime
rs1047796 -- 122,143,672(+) ACTTC(C/T)GTGCC utr-variant-3-prime

Relevant External Links for MLXIP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MLXIP Gene

Disorders for MLXIP Gene

No disorders were found for MLXIP Gene.

No data available for UniProtKB/Swiss-Prot for MLXIP Gene

Publications for MLXIP Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin A.N. … Ayer D.E. (Mol. Cell. Biol. 2000) 2 3 4
  3. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. (PMID: 12446771) Eilers A.L. … Ayer D.E. (Mol. Cell. Biol. 2002) 3 4
  4. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PMID: 18458340) Stoltzman C.A. … Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  5. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PMID: 19706488) Kaadige M.R. … Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for MLXIP Gene

Sources for MLXIP Gene

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