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MLXIP Gene

protein-coding   GIFtS: 50
GCID: GC12P122516

MLX Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MLX Interacting Protein1 2     bHLHe362 3
MONDOA2 3 5     KIAA08673 5
Class E Basic Helix-Loop-Helix Protein 362 3     Mlx Interactor2
Transcriptional Activator MondoA2 3     MLX-Interacting Protein2
MIR2 3     BHLHE363

External Ids:    HGNC: 170551   Entrez Gene: 228772   Ensembl: ENSG000001757277   OMIM: 6080905   UniProtKB: Q9HAP23   

Export aliases for MLXIP gene to outside databases

Previous GC identifers: GC12P121137 GC12P121002 GC12P119572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MLXIP Gene:
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein
forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to
cellular glucose levels. (provided by RefSeq, Mar 2014)

GeneCards Summary for MLXIP Gene:
MLXIP (MLX interacting protein) is a protein-coding gene. Diseases associated with MLXIP include distal hereditary motor neuropathy, and lactic acidosis. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MLX.

UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence
5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in
glucose-responsive gene regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MLXIP gene promoter:
         HOXA9   HOXA9B   STAT1   STAT1beta   STAT1alpha   Meis-1b   STAT3   ZID   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLXIP promoter sequence
   Search Chromatin IP Primers for MLXIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLXIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q21.31

MLXIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLXIP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122516:  view genomic region     (about GC identifiers)

Start:
122,516,628 bp from pter      End:
122,631,894 bp from pter
Size:
115,267 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2 (See protein sequence)
Recommended Name: MLX-interacting protein  
Size: 919 amino acids; 101185 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer with MLX
Sequence caution: Sequence=BAA74890.2; Type=Erroneous initiation;
Secondary accessions: A7MBN0 O94945 Q7LC47 Q8IXP1 Q8TAH9 Q8WVQ0 Q8WYA5
Alternative splicing: 5 isoforms:  Q9HAP2-1   Q9HAP2-2   Q9HAP2-3   Q9HAP2-4   Q9HAP2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLXIP: NX_Q9HAP2

Explore proteomics data for MLXIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLXIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055753.3  
    ENSEMBL proteins: 
     ENSP00000312834   ENSP00000438206   ENSP00000440769   ENSP00000445891   ENSP00000444507  
     ENSP00000366236  

    MLXIP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MLXIP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MLXIP
    GenScript Custom Purified and Recombinant Proteins Services for MLXIP
    Novus Biologicals MLXIP Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLXIP

    MLXIP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
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    Novus Biologicals MLXIP Antibodies
    Search for Antibodies for MLXIP at Abcam
    Cloud-Clone Corp. Antibodies for MLXIP
    ThermoFisher Antibodies for MLXIP
    LSBio Antibodies in human, mouse, rat for MLXIP

    MLXIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MLXIP
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    Cloud-Clone Corp. ELISAs for MLXIP
    Cloud-Clone Corp. CLIAs for MLXIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAP2

    ProtoNet protein and cluster: Q9HAP2

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MLXIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLXIP_HUMAN, Q9HAP2
    Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence
    5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in
    glucose-responsive gene regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    MLXIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLXIP:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLXIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLXIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLXIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLXIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLXIP:
    hsa-mir-421 (MIRT039408), hsa-mir-26b-5p (MIRT029021), hsa-mir-98-5p (MIRT027490), hsa-mir-20a-5p (MIRT050538), hsa-mir-877-5p (MIRT037318), hsa-mir-335-5p (MIRT017115)

    Block miRNA regulation of human, mouse, rat MLXIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLXIP (see all 43):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-146a hsa-miR-29a hsa-miR-134 hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMLXIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MLXIP
    Predesigned siRNA for gene silencing in human, mouse, rat MLXIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MLXIP

    Clone
    Products:
         
    OriGene clones in human, mouse for MLXIP (see all 9)
    OriGene ORF clones in mouse, rat for MLXIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLXIP (NM_014938)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLXIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLXIP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MLXIP
    Browse ESI BIO Cell Lines and PureStem Progenitors for MLXIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLXIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLXIP_HUMAN, Q9HAP2: Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but
    shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial
    membrane and may shuttle between the outer mitochondrial membrane and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005741mitochondrial outer membrane IEA--

    MLXIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MLXIP About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MLXIP):
        Non-alcoholic fatty liver disease (NAFLD)


    MLXIP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLXIP
    Interactions:

        Search GeneGlobe Interaction Network for MLXIP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for MLXIP (Q9HAP22, 3 ENSP000003128344) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXQ9UH923, ENSP000002469124I2D: score=9 STRING: ENSP00000246912
    CNPY2Q9Y2B03, ENSP000002733084I2D: score=2 STRING: ENSP00000273308
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    CHMP6Q96FZ73I2D: score=4 
    INSRP062133I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006913nucleocytoplasmic transport IEA--

    MLXIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLXIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MLXIP gene: 
    NM_014938.5  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319080(uc001ubq.3) ENST00000535430 ENST00000539861(uc001ubr.3)
    ENST00000535876 ENST00000538061(uc001ubs.1) ENST00000538698(uc001ubt.3)
    ENST00000541750 ENST00000366272 ENST00000535996 ENST00000542417 ENST00000377037

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLXIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLXIP (see all 43):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-146a hsa-miR-29a hsa-miR-134 hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMLXIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MLXIP
    Predesigned siRNA for gene silencing in human, mouse, rat MLXIP
    Clone
    Products:
         
    OriGene clones in human, mouse for MLXIP (see all 9)
    OriGene ORF clones in mouse, rat for MLXIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLXIP (NM_014938)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLXIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLXIP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MLXIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLXIP
      QuantiTect SYBR Green Assays in human, mouse, rat MLXIP
      QuantiFast Probe-based Assays in human, mouse, rat MLXIP

    Selected AceView cDNA sequences (see all 519):

    AW503524 BE268223 BF844436 CR601671 BQ645936 BU633003 BQ711236 BF591716 
    BM480328 BM561968 BF925029 AI858496 AW263553 CD518193 BQ445885 BQ643522 
    BP340370 AW576437 BM756858 AF245480 CB160841 AW295350 BQ218664 AA355765 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLXIP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for MLXIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLXIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MLXIP Expression
    About this image


    MLXIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MLXIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLXIP Protein Expression

    UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
    Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle

        Custom PCR Arrays for MLXIP
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLXIP
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    QuantiFast Probe-based Assays in human, mouse, rat MLXIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLXIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MLXIP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlxip1 , 5 MLX interacting protein1, 5 85.24(n)1
    88.02(a)1
      5 (62.95 cM)5
    2081041  NM_133917.31  NP_598678.21 
     1233947985 
    chicken
    (Gallus gallus)
    Aves MLXIP1 MLX interacting protein 66.41(n)
    67.57(a)
      416857  XM_415149.4  XP_415149.4 
    lizard
    (Anolis carolinensis)
    Reptilia MLXIP6
    MLX interacting protein
    61(a)
    1 ↔ 1
    GL343550.1(450498-479406)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.49432 Transcribed sequence with weak similarity to protein more 87.05(n)    BQ392162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mlxip1 MLX interacting protein 61.94(n)
    61.01(a)
      798052  XM_001338467.3  XP_001338503.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mio6
    Mlx interactor
    22(a)
    1 → many
    2L(21286078-21310032)
    worm
    (Caenorhabditis elegans)
    Secernentea mml-16
    Protein MML-1, isoform a (mml-1) mRNA, complete cd...
    20(a)
    1 → many
    III(7370131-7374725) WBGene00003378


    ENSEMBL Gene Tree for MLXIP (if available)
    TreeFam Gene Tree for MLXIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLXIP gene
    MLX2  MLXIPL2  
    1 SIMAP similar gene for MLXIP using alignment to 6 protein entries:     MLXIP_HUMAN (see all proteins):
    MLXIPL

    MLXIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLXIP (see all 1251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358536441,2
    C--122312137(+) AAAAAA/-GTGGC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1852909311,2
    --122312192(+) GAAAGA/GAAGGC 1 -- int10--------
    rs1901054301,2
    --122312236(+) CAGCAC/TTGGGA 1 -- int10--------
    rs1168756381,2
    F--122312328(+) TTGGAA/GATAAG 1 -- int11Minor allele frequency- G:0.02EA 120
    rs41281241,2
    C--122312406(+) GCAGGG/CGACTC 1 -- int12Minor allele frequency- C:0.06NA WA 120
    rs1436508351,2
    --122312669(+) TGGACA/GCCCTG 1 -- int10--------
    rs1414300771,2
    C--122312979(+) ATTTA-/TTTTTC
            
    TTTTT
    1 -- int10--------
    rs719269411,2
    C--122312984(+) TTTTT-/CTTTTT
            
    GAGAC
    1 -- int10--------
    rs1826847101,2
    --122313054(+) GCAACC/TTCCAC 1 -- int10--------
    rs1858131781,2
    --122313173(+) TCACCG/TTGTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MLXIP (122516628 - 122631894 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MLXIP: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MLXIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MLXIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608090    OMIM disorders: --

    13 diseases for MLXIP:    
    About MalaCards
    distal hereditary motor neuropathy    lactic acidosis    williams-beuren syndrome    fatty liver disease
    neuropathy    lymphoblastic leukemia    liver disease    tonsillitis
    leukemia    thyroiditis    cerebritis    endotheliitis
    prostatitis


    MLXIP for disorders           About GeneDecksing


    Export disorders for MLXIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLXIP gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with MLXIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PubMed id 11073985)1, 2, 3 Billin A.N.... Ayer D.E. (Mol. Cell. Biol. 2000)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PubMed id 16782875)1, 2 Sans C.L.... Ayer D.E. (Mol. Cell. Biol. 2006)
    4. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. (PubMed id 12446771)1, 2 Eilers A.L.... Ayer D.E. (Mol. Cell. Biol. 2002)
    5. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PubMed id 18458340)1, 9 Stoltzman C.A....Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PubMed id 19706488)1, 9 Kaadige M.R....Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    8. The Association Study between Twenty One Polymorphisms in Seven Candidate Genes and Coronary Heart Diseases in Chinese Han Population. (PubMed id 23840567)1 Alobeidy B.F....Zheng F. (PLoS ONE 2013)
    9. Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses. (PubMed id 23520550)1 Kanari Y....Muta T. (PLoS ONE 2013)
    10. MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival. (PubMed id 22748921)1 Wernicke C.M....Grunewald T.G. (Leuk. Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22877 HGNC: 17055 AceView: MONDOA Ensembl:ENSG00000175727 euGenes: HUgn22877
    ECgene: MLXIP Kegg: 22877 H-InvDB: MLXIP

    (According to HUGE)
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    HUGE: KIAA0867

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLXIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLXIP gene:
    Search GeneIP for patents involving MLXIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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