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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLXIP Gene

protein-coding   GIFtS: 52
GCID: GC12P122516

MLX Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MLX Interacting Protein1 2     KIAA08673 5
MONDOA2 3 5     MondoA2
Class E Basic Helix-Loop-Helix Protein 362 3     Mlx Interactor2
Transcriptional Activator MondoA2 3     MLX-Interacting Protein2
MIR2 3     BHLHE363
bHLHe362 3     

External Ids:    HGNC: 170551   Entrez Gene: 228772   Ensembl: ENSG000001757277   OMIM: 6080905   UniProtKB: Q9HAP23   

Export aliases for MLXIP gene to outside databases

Previous GC identifers: GC12P121137 GC12P121002 GC12P119572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MLXIP Gene:
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes
(Billin et al., 2000 (PubMed 11073985)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MLXIP Gene: 
MLXIP (MLX interacting protein) is a protein-coding gene. Diseases associated with MLXIP include distal hereditary motor neuropathy, and lactic acidosis, and among its related super-pathways are Respiratory electron transport. GO annotations related to this gene include protein dimerization activity and DNA binding. An important paralog of this gene is MLX.

UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence
5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in
glucose-responsive gene regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLXIP gene promoter:
         HOXA9   HOXA9B   STAT1   STAT1beta   STAT1alpha   Meis-1b   STAT3   ZID   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLXIP promoter sequence
   Search SABiosciences Chromatin IP Primers for MLXIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLXIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q21.31

MLXIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLXIP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122516:  view genomic region     (about GC identifiers)

Start:
122,516,628 bp from pter      End:
122,629,266 bp from pter
Size:
112,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2 (See protein sequence)
Recommended Name: MLX-interacting protein  
Size: 919 amino acids; 101185 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer with MLX
Subcellular location: Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but
shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial
membrane and may shuttle between the outer mitochondrial membrane and the nucleus
Sequence caution: Sequence=BAA74890.2; Type=Erroneous initiation;
Secondary accessions: A7MBN0 O94945 Q7LC47 Q8IXP1 Q8TAH9 Q8WVQ0 Q8WYA5
Alternative splicing: 5 isoforms:  Q9HAP2-1   Q9HAP2-2   Q9HAP2-3   Q9HAP2-4   Q9HAP2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLXIP: NX_Q9HAP2

Explore proteomics data for MLXIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HAP2

  • MLXIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MLXIP Protein Expression
    REFSEQ proteins: NP_055753.3  
    ENSEMBL proteins: 
     ENSP00000312834   ENSP00000438206   ENSP00000440769   ENSP00000445891   ENSP00000444507  
     ENSP00000366236  

    Human Recombinant Protein Products for MLXIP: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLXIP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005741mitochondrial outer membrane IEA--

    MLXIP for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MLXIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAP2

    ProtoNet protein and cluster: Q9HAP2

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MLXIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLXIP_HUMAN, Q9HAP2
    Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence
    5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in
    glucose-responsive gene regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    MLXIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLXIP:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MLXIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MLXIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLXIP 
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    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate MLXIP (see all 43):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-146a hsa-miR-29a hsa-miR-134 hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMLXIP 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MLXIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MLXIP):
        Non-alcoholic fatty liver disease (NAFLD)


    MLXIP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLXIP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for MLXIP (Q9HAP22, 3 ENSP000003128344) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXQ9UH923, ENSP000002469124I2D: score=9 STRING: ENSP00000246912
    CNPY2Q9Y2B03, ENSP000002733084I2D: score=2 STRING: ENSP00000273308
    YWHABP319463, ENSP000003001614I2D: score=2 STRING: ENSP00000300161
    CHMP6Q96FZ73I2D: score=4 
    INSRP062133I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006913nucleocytoplasmic transport IEA--

    MLXIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MLXIP

    Search CenterWatch for drugs/clinical trials and news about MLXIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLXIP gene: 
    NM_014938.4  

    Unigene Clusters for MLXIP:

    MLX interacting protein
    Hs.721711  [show with all ESTs], Hs.731847  [show with all ESTs]
    Unigene Representative Sequences: NM_014938, AF245480
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319080(uc001ubq.3) ENST00000535430 ENST00000539861(uc001ubr.3)
    ENST00000535876 ENST00000538061(uc001ubs.1) ENST00000538698(uc001ubt.3)
    ENST00000541750 ENST00000366272 ENST00000535996 ENST00000542417 ENST00000377037

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLXIP
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate MLXIP (see all 43):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-146a hsa-miR-29a hsa-miR-134 hsa-miR-30d hsa-let-7g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMLXIP 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLXIP

    Additional mRNA sequence: 

    AB020674.1 AF245480.1 AF245481.1 BC017656.1 BC028309.1 BC039704.1 BC069272.1 

    18 DOTS entries:

    DT.100777936  DT.97847382  DT.446646  DT.99927321  DT.75176302  DT.97777937  DT.100777934  DT.91877828 
    DT.95229473  DT.100777935  DT.101978274  DT.92017039  DT.95229489  DT.87016583  DT.91964571  DT.95229470 
    DT.95278103  DT.95320945 

    24/519 AceView cDNA sequences (see all 519):

    BQ711236 BF925029 BM480328 AI191774 AI566930 AW877862 AI952671 AB020674 
    AA355765 BQ883135 BQ218664 F28270 BM713464 BU197156 BQ690892 BP340370 
    BC028309 AW849371 BM852713 AW576437 AI978802 BQ645936 AW503524 BF591716 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MLXIP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for MLXIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLXIP expression in normal human tissues (normalized intensities)      MLXIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MLXIP Expression
    About this image


    MLXIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See MLXIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLXIP

    SOURCE GeneReport for Unigene clusters: Hs.721711 Hs.731847

    UniProtKB/Swiss-Prot: MLXIP_HUMAN, Q9HAP2
    Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle

        SABiosciences Custom PCR Arrays for MLXIP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLXIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLXIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MLXIP gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlxip1 , 5 MLX interacting protein1, 5 85.24(n)1
    88.02(a)1
      5 (62.95 cM)5
    2081041  NM_133917.21  NP_598678.21 
     1233947985 
    chicken
    (Gallus gallus)
    Aves MLXIP1 MLX interacting protein 65.94(n)
    66.84(a)
      416857  XM_415149.3  XP_415149.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    MLXIP6
    (see all 3)
    Uncharacterized protein
    (see all 3)
    68(a)
    62(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    AAWZ02040043(1680-2239)
    GL343550.1(450498-479406)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.49432 Transcribed sequence with weak similarity to protein more 87.05(n)    BQ392162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mlxip1 MLX interacting protein 61.73(n)
    61.56(a)
      798052  XM_001338467.2  XP_001338503.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mio6
    Mlx interactor
    21(a)
    1 → many
    2L(21286078-21310032)
    worm
    (Caenorhabditis elegans)
    Secernentea mml-11 Protein MML-1 41.39(n)
    31.69(a)
      176050  NM_066230.3  NP_498631.2 


    ENSEMBL Gene Tree for MLXIP (if available)
    TreeFam Gene Tree for MLXIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLXIP gene
    MLX2  MLXIPL2  
    1 SIMAP similar gene for MLXIP using alignment to 7 protein entries:     MLXIP_HUMAN (see all proteins):
    MLXIPL

    MLXIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1251 SNPs in MLXIP are shown (see all 1251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358536441,2
    C--122312137(+) AAAAAA/-GTGGC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1852909311,2
    --122312192(+) GAAAGA/GAAGGC 1 -- int10--------
    rs1901054301,2
    --122312236(+) CAGCAC/TTGGGA 1 -- int10--------
    rs1168756381,2
    F--122312328(+) TTGGAA/GATAAG 1 -- int11Minor allele frequency- G:0.02EA 120
    rs41281241,2
    C--122312406(+) GCAGGG/CGACTC 1 -- int12Minor allele frequency- C:0.06NA WA 120
    rs1436508351,2
    --122312669(+) TGGACA/GCCCTG 1 -- int10--------
    rs1414300771,2
    C--122312979(+) ATTTA-/TTTTTC
            
    TTTTT
    1 -- int10--------
    rs719269411,2
    C--122312984(+) TTTTT-/CTTTTT
            
    GAGAC
    1 -- int10--------
    rs1826847101,2
    --122313054(+) GCAACC/TTCCAC 1 -- int10--------
    rs1858131781,2
    --122313173(+) TCACCG/TTGTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MLXIP (122516628 - 122629266 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MLXIP: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MLXIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MLXIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608090    OMIM disorders: --

    7 diseases for MLXIP:    About MalaCards
    distal hereditary motor neuropathy    lactic acidosis    williams-beuren syndrome    neuropathy
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia


    MLXIP for disorders           About GeneDecksing


    Export disorders for MLXIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLXIP gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MLXIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PubMed id 11073985)1, 2, 3 Billin A.N.... Ayer D.E. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PubMed id 16782875)1, 2 Sans C.L.... Ayer D.E. (2006)
    4. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. (PubMed id 12446771)1, 2 Eilers A.L.... Ayer D.E. (2002)
    5. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PubMed id 18458340)1, 9 Stoltzman C.A....Ayer D.E. (2008)
    6. Glutamine-dependent anapleurosis dictates glucose upt ake and cell growth by regulating MondoA transcriptional activity. (PubMed id 19706488)1, 9 Kaadige M.R....Ayer D.E. (2009)
    7. Thioredoxin-interacting protein gene expression via Mo ndoA is rapidly and transiently suppressed during inflammatory responses. (PubMed id 23520550)1 Kanari Y....Muta T. (2013)
    8. MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival. (PubMed id 22748921)1 Wernicke C.M....Grunewald T.G. (2012)
    9. MondoA senses non-glucose sugars: regulation of thior edoxin-interacting protein (TXNIP) and the hexose transport curb. (PubMed id 21908621)1 Stoltzman C.A....Ayer D.E. (2011)
    10. Glucose controls nuclear accumulation, promoter bindi ng, and transcriptional activity of the MondoA-Mlx heterodimer. (PubMed id 20385767)1 Peterson C.W....Ayer D.E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22877 HGNC: 17055 AceView: MONDOA Ensembl:ENSG00000175727 euGenes: HUgn22877
    ECgene: MLXIP Kegg: 22877 H-InvDB: MLXIP

    (According to HUGE)
    About This Section
    HUGE: KIAA0867

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLXIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLXIP gene:
    Search GeneIP for patents involving MLXIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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