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MLX Gene

protein-coding   GIFtS: 59
GCID: GC17P040719

MLX, MAX Dimerization Protein

(Previous names: transcription factor-like 4, MAX-like protein X)
(Previous symbol: TCFL4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MLX, MAX Dimerization Protein1 2     Transcription Factor-Like 41
TCFL41 2 3 5     MAD72
MAX-Like Protein X1 2     MXD72
Class D Basic Helix-Loop-Helix Protein 132 3     BigMax Protein2
Max-Like BHLHZip Protein2 3     BHLHD133
Transcription Factor-Like Protein 42 3     Protein BigMax3
bHLHd132 3     

External Ids:    HGNC: 116451   Entrez Gene: 69452   Ensembl: ENSG000001087887   OMIM: 6029765   UniProtKB: Q9UH923   

Export aliases for MLX gene to outside databases

Previous GC identifers: GC17P037973 GC17P036483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MLX Gene:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription
factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and
differentiation. This gene product may act to diversify Mad family function by its restricted association with a
subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript
variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MLX Gene:
MLX (MLX, MAX dimerization protein) is a protein-coding gene. Diseases associated with MLX include takayasu's arteritis, and williams-beuren syndrome. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MLXIPL.

UniProtKB/Swiss-Prot: MLX_HUMAN, Q9UH92
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT,
WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14
complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes.
Involved in glucose-responsive gene regulation

Gene Wiki entry for MLX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MLX gene promoter:
         Egr-3   PPAR-gamma1   Pax-6   Pax-2a   PPAR-gamma2   C/EBPalpha   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLX promoter sequence
   Search Chromatin IP Primers for MLX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.1

MLX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLX gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040719:  view genomic region     (about GC identifiers)

Start:
40,719,078 bp from pter      End:
40,725,257 bp from pter
Size:
6,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MLX_HUMAN, Q9UH92 (See protein sequence)
Recommended Name: Max-like protein X  
Size: 298 amino acids; 33300 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer
Secondary accessions: A8K2J3 B2RAV8 B2RD73 Q53XM6 Q96FL2 Q9H2V0 Q9H2V1 Q9H2V2 Q9NXN3
Alternative splicing: 3 isoforms:  Q9UH92-1   Q9UH92-2   Q9UH92-3   

Explore the universe of human proteins at neXtProt for MLX: NX_Q9UH92

Explore proteomics data for MLX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys170, Lys179
  • Modification sites at PhosphoSitePlus

  • See MLX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_733752.1  NP_937847.1  NP_937848.1  

    ENSEMBL proteins: 
     ENSP00000416627   ENSP00000246912   ENSP00000320913   ENSP00000464697  
    Reactome Protein details: Q9UH92

    MLX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MLX
    OriGene Protein Over-expression Lysate for MLX
    OriGene MassSpec for MLX
    OriGene Custom Protein Services for MLX
    GenScript Custom Purified and Recombinant Proteins Services for MLX
    Novus Biologicals MLX Proteins
    Novus Biologicals MLX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLX

    MLX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MLX
    OriGene Antibodies for MLX
    OriGene Custom Antibody Services for MLX
    Novus Biologicals MLX Antibodies
    Abcam antibodies for MLX
    Cloud-Clone Corp. Antibodies for MLX
    Search ThermoFisher Antibodies for MLX
    LSBio Antibodies in human, mouse, rat for MLX

    MLX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MLX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MLX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MLX
    Cloud-Clone Corp. CLIAs for MLX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MXD: MAX dimerization proteins
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9UH92

    ProtoNet protein and cluster: Q9UH92

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MLX_HUMAN, Q9UH92
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MLX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLX_HUMAN, Q9UH92
    Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT,
    WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14
    complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes.
    Involved in glucose-responsive gene regulation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA11230181
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10918583
    GO:0008134transcription factor binding IPI11230181
    GO:0042803protein homodimerization activity IPI11230181
    GO:0046982protein heterodimerization activity IPI11230181
         
    MLX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLX:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLX

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLX:
    hsa-mir-92a-3p (MIRT049076), hsa-mir-320b (MIRT036245), hsa-mir-149-5p (MIRT045597), hsa-mir-484 (MIRT041914), hsa-mir-33a-5p (MIRT028193), hsa-mir-218-5p (MIRT046985), hsa-mir-320a (MIRT044847), hsa-mir-378a-3p (MIRT043912)

    Block miRNA regulation of human, mouse, rat MLX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLX (see all 16):
    hsa-miR-3655 hsa-miR-1271 hsa-miR-578 hsa-miR-374a hsa-miR-512-3p hsa-miR-1304 hsa-miR-96 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMLX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MLX
    Predesigned siRNA for gene silencing in human, mouse, rat MLX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MLX

    Clone
    Products:
         
    OriGene clones in human, mouse for MLX (see all 19)
    OriGene ORF clones in mouse, rat for MLX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MLX (NM_198204)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MLX
    Browse ESI BIO Cell Lines and PureStem Progenitors for MLX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLX_HUMAN, Q9UH92: Isoform Alpha: Cytoplasm. Note=Found predominantly in the cytoplasm
    MLX_HUMAN, Q9UH92: Isoform Beta: Cytoplasm. Note=Found predominantly in the cytoplasm
    MLX_HUMAN, Q9UH92: Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10918583
    GO:0005737cytoplasm IDA10918583

    MLX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MLX About    
    See pathways by source

    SuperPathContained pathways About
    1Integration of energy metabolism
    Integration of energy metabolism0.75
    ChREBP activates metabolic gene expression0.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MLX
        ChREBP activates metabolic gene expression


    1 Kegg Pathway  (Kegg details for MLX):
        Non-alcoholic fatty liver disease (NAFLD)


    MLX for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MLX: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MLX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MLX (Q9UH922, 3 ENSP000002469124) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605202, 3, ENSP000000372434MINT-66142 I2D: score=5 STRING: ENSP00000037243
    MXD4Q145823, ENSP000003378894I2D: score=3 STRING: ENSP00000337889
    MAD1L1Q9Y6D93, ENSP000003825624I2D: score=2 STRING: ENSP00000382562
    ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
    SAP30BPQ9UHR53, ENSP000003475924I2D: score=1 STRING: ENSP00000347592
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS10593926
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0031325positive regulation of cellular metabolic process TAS--

    MLX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLX

    2 Novoseek inferred chemical compound relationships for MLX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 34.3 1 15163635 (1)
    glucose 26.5 19 18458340 (6), 15664996 (5), 16885160 (2), 19706488 (2)



    MLX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MLX gene (3 alternative transcripts): 
    NM_170607.2  NM_198204.1  NM_198205.1  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435881(uc002iaf.3) ENST00000246912(uc002iag.3) ENST00000346833(uc002iah.3)
    ENST00000590050 ENST00000591024 ENST00000590084 ENST00000592717 ENST00000585403
    ENST00000586393 ENST00000591195 ENST00000588320
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLX (see all 16):
    hsa-miR-3655 hsa-miR-1271 hsa-miR-578 hsa-miR-374a hsa-miR-512-3p hsa-miR-1304 hsa-miR-96 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMLX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MLX
    Predesigned siRNA for gene silencing in human, mouse, rat MLX
    Clone
    Products:
         
    OriGene clones in human, mouse for MLX (see all 19)
    OriGene ORF clones in mouse, rat for MLX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MLX (NM_198204)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MLX
    OriGene qSTAR qPCR primer pairs in human, mouse for MLX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLX
      QuantiTect SYBR Green Assays in human, mouse, rat MLX
      QuantiFast Probe-based Assays in human, mouse, rat MLX

    Selected AceView cDNA sequences (see all 808):

    BM990242 BM711196 BQ650983 BG254097 NM_198204 BU902227 CD723005 BM480288 
    BU727232 AA809936 BM671929 AW068286 BM781531 AL583142 BI492233 BQ052592 
    AI055833 CA443164 CA430245 BM829775 BM560518 BI858383 CB112870 BU624011 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLX (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:              -           -                 -                       -                 -                           
    SP2:                          -                 -                       -                                             
    SP3:                          -                                         -                 -                           
    SP4:                          -     -           -                       -                 -                           
    SP5:              -           -                 -                                                                     


    ECgene alternative splicing isoforms for MLX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAGTGTT
    MLX Expression
    About this image

    MLX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLX Protein Expression

    UniProtKB/Swiss-Prot: MLX_HUMAN, Q9UH92
    Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon,
    peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis,
    brain, placenta and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including MLX: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MLX
    OriGene qSTAR qPCR primer pairs in human, mouse for MLX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLX
    QuantiTect SYBR Green Assays in human, mouse, rat MLX
    QuantiFast Probe-based Assays in human, mouse, rat MLX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MLX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mlx1 , 5 MAX-like protein X1, 5 90.49(n)1
    95.3(a)1
      11 (64.18 cM)5
    214281  NM_011550.31  NP_035680.31 
     1010872775 
    chicken
    (Gallus gallus)
    Aves MLX1 MAX-like protein X 79.69(n)
    84.87(a)
      420026  NM_001030930.1  NP_001026101.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLX6
    MLX, MAX dimerization protein
    87(a)
    1 ↔ 1
    6(61752504-61760359)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150072 Xenopus laevis transcribed sequence with moderate similarity more 76.21(n)    CA789463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD052797.12   -- 78.1(n)   322434  CD052797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bigmax1 bigmax 60.41(n)
    51.78(a)
      43293  NM_143299.3  NP_651556.2 


    ENSEMBL Gene Tree for MLX (if available)
    TreeFam Gene Tree for MLX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MLX gene
    MLXIPL2  MLXIP2  
    2 SIMAP similar genes for MLX using alignment to 2 protein entries:     MLX_HUMAN (see all proteins):
    MAX    ARNTL

    MLX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MLX
    PGOHUM00000241121


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLX (see all 264)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478806191,2
    C--41506250(+) TTCCTA/GAGGGC 3 -- us2k10--------
    rs1846019881,2
    C--41506265(+) AAGCCA/GCTACT 3 -- us2k10--------
    rs1144390491,2
    F--41506307(+) CTGGTC/TTGGCC 3 -- us2k11Minor allele frequency- T:0.06WA 118
    rs778835311,2
    F--41506326(+) CATTTC/GCATTG 3 -- us2k11Minor allele frequency- G:0.18WA 118
    rs1998226091,2
    C,F--41506390(+) ACCTCT/CGCCCT 3 -- us2k11Minor allele frequency- C:0.00EU 593
    rs2020819741,2
    C--41506432(+) CTCACA/GGACAT 3 -- us2k10--------
    rs2009081471,2
    --41506440(+) CATTAG/TGTGGC 3 -- us2k10--------
    rs1999536311,2
    C--41506444(+) ATGTGC/GCCAAT 3 -- us2k10--------
    rs2004916991,2
    C--41506466(+) TGGCCC/G/TGAGAG 3 -- us2k10--------
    rs1997873451,2
    --41506503(+) TGAGTG/TGGAGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLX (40719078 - 40725257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MLX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908255CNV Loss21882294
    dgv3172n71CNV Loss21882294
    nsv908249CNV Loss21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLX
    DNA2.0 Custom Variant and Variant Library Synthesis for MLX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602976    OMIM disorders: --

    11 diseases for MLX:    
    About MalaCards
    takayasu's arteritis    williams-beuren syndrome    crohn's disease    fatty liver disease
    liver disease    hypertension    malaria    neuroblastoma
    alzheimer's disease    hepatitis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for MLX:
    Cerebrovascular accident     Heart disease     Hypertension

    MLX for disorders           About GeneDecksing

    Genetic Association Database (GAD): MLX
    Human Genome Epidemiology (HuGE) Navigator: MLX (2 documents)

    Export disorders for MLX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLX gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MLX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors. (PubMed id 10593926)1, 2, 9 Billin A.N.... Ayer D.E. (J. Biol. Chem. 1999)
    2. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PubMed id 10918583)1, 2, 9 Meroni G....Reymond A. (Oncogene 2000)
    3. TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. (PubMed id 8973301)1, 3, 9 Bjerknes M. and Cheng H. (Gene 1996)
    4. MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PubMed id 16782875)1, 2 Sans C.L.... Ayer D.E. (Mol. Cell. Biol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. (PubMed id 12446771)1, 2 Eilers A.L.... Ayer D.E. (Mol. Cell. Biol. 2002)
    8. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PubMed id 18458340)1, 9 Stoltzman C.A....Ayer D.E. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. (PubMed id 15664996)1, 9 Ma L....Towle H.C. (J. Biol. Chem. 2005)
    10. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PubMed id 11073985)1, 9 Billin A.N.... Ayer D.E. (Mol. Cell. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6945 HGNC: 11645 AceView: COASYandTCFL4 Ensembl:ENSG00000108788 euGenes: HUgn6945
    ECgene: MLX Kegg: 6945 H-InvDB: MLX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MLX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MLX gene:
    Search GeneIP for patents involving MLX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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