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Aliases for MLX Gene

Aliases for MLX Gene

  • MLX, MAX Dimerization Protein 2 3
  • TCFL4 3 4 6
  • Class D Basic Helix-Loop-Helix Protein 13 3 4
  • Transcription Factor-Like Protein 4 3 4
  • MAX-Like Protein X 2 3
  • BHLHd13 3 4
  • Transcription Factor-Like 4 2
  • MAX-Like BHLHZIP Protein 3
  • Max-Like BHLHZip Protein 4
  • BigMax Protein 3
  • Protein BigMax 4
  • MAD7 3
  • MXD7 3

External Ids for MLX Gene

Previous Symbols for MLX Gene

  • TCFL4

Summaries for MLX Gene

Entrez Gene Summary for MLX Gene

  • The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MLX Gene

MLX (MLX, MAX Dimerization Protein) is a Protein Coding gene. Diseases associated with MLX include takayasus arteritis. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MLXIP.

UniProtKB/Swiss-Prot for MLX Gene

  • Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5-CACGTG-3. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Gene Wiki entry for MLX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLX Gene

Genomics for MLX Gene

Genomic Location for MLX Gene

Start:
42,567,060 bp from pter
End:
42,573,239 bp from pter
Size:
6,180 bases
Orientation:
Plus strand

Genomic View for MLX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLX Gene

Regulatory Elements for MLX Gene

Proteins for MLX Gene

  • Protein details for MLX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH92-MLX_HUMAN
    Recommended name:
    Max-like protein X
    Protein Accession:
    Q9UH92
    Secondary Accessions:
    • A8K2J3
    • B2RAV8
    • B2RD73
    • Q53XM6
    • Q96FL2
    • Q9H2V0
    • Q9H2V1
    • Q9H2V2
    • Q9NXN3

    Protein attributes for MLX Gene

    Size:
    298 amino acids
    Molecular mass:
    33300 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.

    Alternative splice isoforms for MLX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLX Gene

Proteomics data for MLX Gene at MOPED

Post-translational modifications for MLX Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys170 and Lys179

Other Protein References for MLX Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MLX Gene

Domains for MLX Gene

Gene Families for MLX Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins
  • MXD :MAX dimerization proteins

Protein Domains for MLX Gene

UniProtKB/Swiss-Prot:

MLX_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q9UH92
genes like me logo Genes that share domains with MLX: view

Function for MLX Gene

Molecular function for MLX Gene

UniProtKB/Swiss-Prot Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5-CACGTG-3. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Gene Ontology (GO) - Molecular Function for MLX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10918583
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP 10918583
GO:0003677 DNA binding IDA 11230181
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10918583
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MLX: view

Phenotypes for MLX Gene

GenomeRNAi human phenotypes for MLX:
genes like me logo Genes that share phenotypes with MLX: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLX Gene

Localization for MLX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLX Gene

Isoform Alpha: Cytoplasm. Note=Found predominantly in the cytoplasm.
Isoform Beta: Cytoplasm. Note=Found predominantly in the cytoplasm.
Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLX Gene COMPARTMENTS Subcellular localization image for MLX gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MLX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10918583
GO:0005737 cytoplasm IDA 10918583
genes like me logo Genes that share ontologies with MLX: view

Pathways for MLX Gene

genes like me logo Genes that share pathways with MLX: view

Pathways by source for MLX Gene

Gene Ontology (GO) - Biological Process for MLX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 10918583
GO:0006112 energy reserve metabolic process TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10593926
GO:0006913 nucleocytoplasmic transport IEA --
genes like me logo Genes that share ontologies with MLX: view

Compounds for MLX Gene

(2) Novoseek inferred chemical compound relationships for MLX Gene

Compound -log(P) Hits PubMed IDs
leucine 34.3 1
glucose 26.5 15
genes like me logo Genes that share compounds with MLX: view

Transcripts for MLX Gene

Unigene Clusters for MLX Gene

MLX, MAX dimerization protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - -
SP9: -
SP10: -

Relevant External Links for MLX Gene

GeneLoc Exon Structure for
MLX
ECgene alternative splicing isoforms for
MLX

Expression for MLX Gene

mRNA expression in normal human tissues for MLX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLX Gene

SOURCE GeneReport for Unigene cluster for MLX Gene Hs.714749

mRNA Expression by UniProt/SwissProt for MLX Gene

Q9UH92-MLX_HUMAN
Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
genes like me logo Genes that share expressions with MLX: view

Orthologs for MLX Gene

This gene was present in the common ancestor of animals.

Orthologs for MLX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLX 36
  • 99.66 (n)
  • 100 (a)
MLX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLX 36
  • 93.97 (n)
  • 97.41 (a)
MLX 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLX 36
  • 93.62 (n)
  • 95.3 (a)
MLX 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlx 36
  • 90.49 (n)
  • 95.3 (a)
Mlx 16
Mlx 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLX 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLX 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlx 36
  • 91.05 (n)
  • 95.64 (a)
chicken
(Gallus gallus)
Aves MLX 36
  • 79.69 (n)
  • 84.87 (a)
MLX 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLX 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15007 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mlx 36
  • 74.75 (n)
  • 79.7 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
mlx 36
  • 75.46 (n)
  • 77.87 (a)
mlx 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000682 36
  • 57.82 (n)
  • 51.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta bigmax 36
  • 60.41 (n)
  • 51.78 (a)
bigmax 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for MLX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLX Gene

ENSEMBL:
Gene Tree for MLX (if available)
TreeFam:
Gene Tree for MLX (if available)

Paralogs for MLX Gene

Paralogs for MLX Gene

Selected SIMAP similar genes for MLX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MLX Gene

genes like me logo Genes that share paralogs with MLX: view

Variants for MLX Gene

Sequence variations from dbSNP and Humsavar for MLX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs585722 -- 42,571,720(+) GGTTT(C/G)TACTT utr-variant-3-prime
rs632758 -- 42,569,342(-) GCCCC(G/T)CTTGG intron-variant
rs646123 -- 42,568,614(-) AGGTA(C/T)TACAA intron-variant
rs646174 -- 42,568,587(-) CCCCC(C/T)GAGGT intron-variant
rs650558 -- 42,569,024(+) TCAGA(C/T)AGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLX Gene

Variant ID Type Subtype PubMed ID
nsv908249 CNV Loss 21882294
dgv3172n71 CNV Loss 21882294
esv33998 OTHER Inversion 15654335
nsv908255 CNV Loss 21882294

Relevant External Links for MLX Gene

HapMap Linkage Disequilibrium report
MLX

Disorders for MLX Gene

(1) MalaCards Diseases for MLX Gene

Search for MLX Gene in MalaCards »

(3) University of Copenhagen DISEASES for MLX Gene

Relevant External Links for MLX

Genetic Association Database (GAD)
MLX
Human Genome Epidemiology (HuGE) Navigator
MLX
genes like me logo Genes that share disorders with MLX: view

No data available for UniProtKB/Swiss-Prot for MLX Gene

Publications for MLX Gene

  1. TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. (PMID: 8973301) Bjerknes M. … Cheng H. (Gene 1996) 2 3 23
  2. Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors. (PMID: 10593926) Billin A.N. … Ayer D.E. (J. Biol. Chem. 1999) 3 4 23
  3. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PMID: 10918583) Meroni G. … Reymond A. (Oncogene 2000) 3 4 23
  4. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin A.N. … Ayer D.E. (Mol. Cell. Biol. 2000) 3 23
  5. WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. (PMID: 11230181) Cairo S. … Reymond A. (Hum. Mol. Genet. 2001) 3 23

Products for MLX Gene

Sources for MLX Gene

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