MLST8 Gene
protein-coding GIFtS: 56
GCID: GC16P002254
|
|
MTOR associated protein, LST8 homolog (S. cerevisiae)
| |
Aliases
for MLST8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MTOR Associated Protein, LST8 Homolog (S. Cerevisiae)1 2 | | WAT12 5 | | GBL1 2 3 5 | | Lst81 | | LST82 3 5 | | Pop31 | | GbetaL1 2 | | Gable3 | | Mammalian Lethal With SEC13 Protein 82 3 | | Target Of Rapamycin Complex Subunit LST82 | | Protein GbetaL2 3 | | Gable3 | | TORC Subunit LST82 3 | | G Protein Beta Subunit-Like3 | | POP32 5 | | MLST81 |
Export aliases for MLST8 gene to outside databasesPrevious GC identifers: GC16P002196 GC16P002255 GC16P002182 |
Summaries
for MLST8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LST8_HUMAN, Q9BVC4Function: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient andhormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPasethat potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires itsrelocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulatesprotein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylatesEIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates andactivates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it fordegradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poorconditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 isalso activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of RhoGTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchangefactors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' byPDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2also modulates the phosphorylation of PRKCA on 'Ser-657'
Gene Wiki entry for MLST8
|
Genomic Views
for MLST8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MLST8
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLST8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLST8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3MLST8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002254: view genomic region
(about GC identifiers)
Start:
|
2,254,249 bp from pter |
End:
|
2,259,418 bp from pter |
Size:
|
5,170 bases |
Orientation:
|
plus strand |
|
Proteins
for MLST8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LST8_HUMAN, Q9BVC4 (See
protein sequence)Recommended Name: Target of rapamycin complex subunit LST8 Size: 326 amino acids; 35876 Da
Subunit: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2(mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to andis not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=EAW85539.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KMM4 B4DY00 D3DU88 Q5M800 Q86Y18 Q8WUI5 Q9HA66 Q9UJV6Alternative splicing: 3 isoforms: Q9BVC4-1 Q9BVC4-3 Q9BVC4-4 (Contains a phosphoserine at position 7. Contains a N-acetylmethionine at position 1)Explore the universe of human proteins at neXtProt for MLST8: NX_Q9BVC4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVC4
MLST8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001186102.1 NP_001186103.1 NP_001186104.1 NP_071767.3
ENSEMBL proteins: ENSP00000455642 ENSP00000454698 ENSP00000457870 ENSP00000371888 ENSP00000456405 ENSP00000454629 ENSP00000456063 ENSP00000456944 ENSP00000455850 ENSP00000456046 ENSP00000455475 ENSP00000454235 ENSP00000459612 ENSP00000456076 ENSP00000301724 ENSP00000455458 ENSP00000380313 ENSP00000455046 ENSP00000301725 Reactome Protein details: Q9BVC4
Human Recombinant Protein Products for MLST8:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MLST8 for ontologies About GeneDecksing
MLST8 Antibody Products:
Assay Products for MLST8: |
Protein
Domains /
Families
for MLST8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLST8 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BVC4ProtoNet protein and cluster: Q9BVC4 UniProtKB/Swiss-Prot: LST8_HUMAN, Q9BVC4Similarity: Belongs to the WD repeat LST8 familySimilarity: Contains 7 WD repeats |
Function
for MLST8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LST8_HUMAN, Q9BVC4Function: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient andhormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPasethat potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires itsrelocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulatesprotein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylatesEIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates andactivates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it fordegradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poorconditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 isalso activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of RhoGTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchangefactors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' byPDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2also modulates the phosphorylation of PRKCA on 'Ser-657' Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MLST8 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mlst8):
MLST8 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MLST8 (NM_001199174) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLST8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLST8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLST8 |
|
Pathways & Interactions
for MLST8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PIP3 activates AKT signaling | | | 3 | IRS-related events | | | 4 | Immune System | | | 5 | mTOR signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for MLST8
5/9  BioSystems Pathways for MLST8 (see all 9)
5/45 
Reactome Pathways for MLST8 (see all 45)
1 
Kegg Pathway (Kegg details for MLST8):
MLST8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MLST8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/396 Interacting proteins for MLST8 (Q9BVC41, 3 ENSP000003718884) via UniProtKB, MINT, STRING, and/or I2D (see all 396)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- | | GO:0008286 | insulin receptor signaling pathway |
TAS | -- | | GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | -- | | GO:0030838 | positive regulation of actin filament polymerization |
IEA | -- | | GO:0031295 | T cell costimulation |
TAS | -- |
MLST8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MLST8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MLST8 for compounds About GeneDecksing
 Browse Tocris compounds for MLST8
6 Novoseek chemical compound relationships for MLST8 gene About this table
Search CenterWatch for drugs/clinical trials and news about MLST8 / LST8
|
Transcripts
for MLST8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLST8 gene (4 alternative transcripts): NM_001199173.1 NM_001199174.1 NM_001199175.1 NM_022372.4 Unigene Cluster for MLST8: MTOR associated protein, LST8 homolog (S. cerevisiae) Hs.29203 [show with all ESTs]Unigene Representative Sequence: BC05229218/36 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 36): ENST00000562043 ENST00000563179 ENST00000565926 ENST00000569457 ENST00000564088(uc002coy.3 uc002cpc.3)
ENST00000382450 ENST00000569417(uc002cpb.3 uc002coz.3 uc010uvx.2)
ENST00000570224 ENST00000568542(uc002cpd.3) ENST00000564294(uc010uvy.2)
ENST00000562851 ENST00000562352 ENST00000565330 ENST00000567623 ENST00000567928
ENST00000562479 ENST00000562844 ENST00000565269
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): MLST8 (NM_001199174) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLST8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLST8 |
Additional cDNA sequence: AF195883.1 AK021536.1 AK022227.1 AK098762.1 AK302201.1 AK304390.1 AY223837.1 BC001313.2 BC017119.1 BC052292.1 BC088354.1 24/30 DOTS entries (see all 30): DT.447261 DT.100842882 DT.95268698 DT.100803442 DT.95268700 DT.100842880 DT.100842886 DT.100842889 DT.91771751 DT.92020928 DT.100842881 DT.91771766 DT.120681470 DT.100772914 DT.120681448 DT.100842878 DT.100842896 DT.95268696 DT.100842869 DT.70103990 DT.91771764 DT.92016464 DT.100767237 DT.100842883 24/393 AceView cDNA sequences (see all 393): BU787649 AA587207 CR625821 CR613800 BQ424372 BM552443 CR596002 BM708569 CR599293 BM800847 CR617593 BU195141 BX457638 BE260143 BM668001 BM547247 BQ877791 BI766587 BQ064206 AI627712 BG291182 CR610557 BM792619 BI829272
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MLST8 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | |
| ExUns: | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for MLST8
|
Expression
for MLST8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLST8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAGGTGGA
About this image
See MLST8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLST8
SOURCE GeneReport for Unigene cluster: Hs.29203
UniProtKB/Swiss-Prot: LST8_HUMAN, Q9BVC4Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, heart and kidney
SABiosciences Expression via Pathway-Focused PCR Array including MLST8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLST8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLST8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLST8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLST8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLST8 |
Orthologs
for MLST8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MLST8 gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for MLST8 (if available)
TreeFam Gene Tree for MLST8 (if available) |
Paralogs
for MLST8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MLST8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MLST8 (2254249 - 2259418 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MLST8
2 CNVs: 30002 5329 | 1 SABiosciences Cancer Mutation PCR Assay for MLST8: | Cosmic Id | AA Change |
|---|
| 86101 | p.Q312R |
|
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLST8 |
|
Disorders
/ Diseases
for MLST8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MLST8 for disorders About GeneDecksing
OMIM gene information: 612190
OMIM disorders: --
17  diseases for MLST8: About MalaCardshuman t-cell leukemia virus type 1 tuberous sclerosis mental disorders bipolar disorder
t-cell leukemia embryonal carcinoma cholera alzheimer's disease
colon cancer schizophrenia leukemia neuroblastoma
retinitis carcinoma pancreatitis hepatitis
neuronitis
1 Novoseek disease relationship for MLST8 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
0 |
2 |
12043849 (1) |
Human Genome Epidemiology (HuGE) Navigator: MLST8 (1 document)
Export disorders for MLST8 gene to outside databases
|
Publications
for MLST8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MLST8 gene, integrated from 9 sources (see all 123):
(articles sorted by number of sources associating them with MLST8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2 Pearce L.R.... Alessi D.R. (2007)
- Rheb binds and regulates the mTOR kinase. (PubMed id 15854902)1, 2 Long X....Avruch J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)1, 2 Jacinto E....Hall M.N. (2004)
- GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PubMed id 12718876)1, 2 Kim D.-H.... Sabatini D.M. (2003)
- Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. (PubMed id 12408816)1, 2 Loewith R.... Hall M.N. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Reconstitution of leucine-mediated autophagy via the m TORC1-Barkor pathway in vitro. (PubMed id 22258093)1 Yan X....Zhong Q. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- p62 is a key regulator of nutrient sensing in the mTO RC1 pathway. (PubMed id 21981924)1 Duran A....Diaz-Meco M.T. (2011)
|
External Searches for MLST8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MLST8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MLST8 gene
(According to HUGE)
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Specialized Databases showing MLST8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MLST8 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for MLST8 gene:
Search GeneIP for patents involving MLST8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MLST8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for MLST8 | | OriGene shRNA RFP for MLST8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLST8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLST8 | | | OriGene Protein Over-expression Lysate for MLST8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLST8 | | OriGene 3'-UTR Clone for MLST8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLST8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MLST8 | | OriGene Custom Protein Services for MLST8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MLST8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLST8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLST8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLST8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLST8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLST8 |
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| | Antibodies & Assays for MLST8 (LST8) |
| | | | Search Tocris compounds for MLST8 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLST8 |
|  |  |  |  | | | | ThermoFisher Antibodies for MLST8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLST8 |
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