Aliases for MLNR Gene
External Ids for MLNR Gene
Previous HGNC Symbols for MLNR Gene
Previous GeneCards Identifiers for MLNR Gene
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
GeneCards Summary for MLNR Gene
MLNR (Motilin Receptor) is a Protein Coding gene. Diseases associated with MLNR include functional colonic disease and colonic pseudo-obstruction. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and growth hormone-releasing hormone receptor activity. An important paralog of this gene is GPR39.
UniProtKB/Swiss-Prot for MLNR Gene
Receptor for motilin.
Motilin Receptors are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. They are found at their highest concentrations in the nerves of the antral wall of the stomach and are also found at significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric nervous system. Motilin receptors promote gastric emptying after food intake and increase smooth muscle contraction in the GI tract. Motilin receptors have not been identified in rodents, but have been cloned in rabbits and humans. The human motilin receptor gene is localized on chromosome 13q14-q21.