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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MLNR Gene

protein-coding   GIFtS: 57
GCID: GC13P049794

Motilin Receptor

(Previous name: G protein-coupled receptor 38)
(Previous symbol: GPR38)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Motilin Receptor1 2
GPR381 2 3 5
G Protein-Coupled Receptor 381 2
MTLR12 3
MTLR3
G-Protein Coupled Receptor 383

External Ids:    HGNC: 44951   Entrez Gene: 28622   Ensembl: ENSG000001025397   OMIM: 6028855   UniProtKB: O431933   

Export aliases for MLNR gene to outside databases

Previous GC identifers: GC13P047593 GC13P048692 GC13P030588


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MLNR Gene:
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein
encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This
member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of
hypomotility disorders. (provided by RefSeq, Aug 2011)

GeneCards Summary for MLNR Gene: 
MLNR (motilin receptor) is a protein-coding gene. Diseases associated with MLNR include colonic pseudo-obstruction, and diabetic autonomic neuropathy, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include growth hormone-releasing hormone receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: MTLR_HUMAN, O43193
Function: Receptor for motilin

summary for MLNR Gene:
Motilin Receptors are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. They are found
at their highest concentrations in the nerves of the antral wall of the stomach and are also found at
significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric
nervous system. Motilin receptors promote gastric emptying after food intake and increase smooth muscle
contraction in the GI tract. Motilin receptors have not been identified in rodents, but have been cloned in
rabbits and humans. The human motilin receptor gene is localized on chromosome 13q14-q21.

Gene Wiki entry for MLNR (Motilin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MLNR gene promoter:
         STAT1   AML1a   Pax-2   FOXD3   STAT1beta   Pax-2a   STAT1alpha   Egr-2   IRF-7A   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLNR promoter sequence
   Search SABiosciences Chromatin IP Primers for MLNR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLNR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14-q21   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14-q21

MLNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLNR gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P049794:  view genomic region     (about GC identifiers)

Start:
49,794,474 bp from pter      End:
49,796,513 bp from pter
Size:
2,040 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTLR_HUMAN, O43193 (See protein sequence)
Recommended Name: Motilin receptor  
Size: 412 amino acids; 45344 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Alternative splicing: 2 isoforms:  O43193-1   O43193-2   

Explore the universe of human proteins at neXtProt for MLNR: NX_O43193

Explore proteomics data for MLNR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43193

  • MLNR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MLNR Protein Expression
    REFSEQ proteins: NP_001498.1  
    ENSEMBL proteins: 
     ENSP00000218721   ENSP00000381352  
    Reactome Protein details: O43193
    Human Recombinant Protein Products for MLNR: 
    EMD Millipore Purified and/or Recombinant MLNR Protein
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    OriGene Protein Over-expression Lysate for MLNR
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    GenScript Custom Purified and Recombinant Proteins Services for MLNR
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLNR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10381885
    GO:0016021integral to membrane ----

    MLNR for ontologies           About GeneDecksing



    MLNR Antibody Products: 
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    GenScript MLNR-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for MLNR 
    Cloud-Clone Corp. CLIAs for MLNR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MLNR: GPCR / Class A : Motilin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: motilin receptor 
    Motilin receptor

    3 InterPro protein domains:
     IPR003905 GHS-R
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O43193

    ProtoNet protein and cluster: O43193

    UniProtKB/Swiss-Prot: MTLR_HUMAN, O43193
    Similarity: Belongs to the G-protein coupled receptor 1 family


    MLNR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTLR_HUMAN, O43193
    Function: Receptor for motilin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10381885
    GO:0016520growth hormone-releasing hormone receptor activity IEA--
         
    MLNR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MLNR:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MLNR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MLNR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLNR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLNR 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLNR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MLNR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MLNR
        GPCRs, Class A Rhodopsin-like

    5/8        Reactome Pathways for MLNR (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for MLNR):
        Neuroactive ligand-receptor interaction


    MLNR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLNR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for MLNR (O431933 ENSP000002187214) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GHRHRQ026433, ENSP000003201804I2D: score=1 STRING: ENSP00000320180
    MLNP128723, ENSP000002660034I2D: score=1 STRING: ENSP00000266003
    GHRLQ9UBU33, ENSP000003350744I2D: score=2 STRING: ENSP00000335074
    SLC9A3R1ENSP000002626134STRING: ENSP00000262613
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS10381885
    GO:0007586digestion TAS10381885

    MLNR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MLNR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MLNR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Motilin (human, porcine) Endogenous peptide regulator of gastrointestinal motility[52906-92-0]

    10/25 IUPHAR Ligands for MLNR (motilin receptor) (see all 25)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [125I]motilin (human)
    AgonistFull agonist1010381885
    motilin
    AgonistFull agonist9.710381885
    [nLeu13,Glu14]motilin (human)
    AgonistFull agonist9.510381885
    motilin-(1-19) (human)
    AgonistFull agonist9.510381885
    motilin-(1-13) (human)
    AgonistFull agonist9.510381885
    motilin
    AgonistFull agonist9.310381885
    MA-2029
    AntagonistAntagonist9.218164286
    motilin-(1-12) (human)
    AgonistFull agonist910381885
    [Leu13]motilin (human)
    AgonistFull agonist910381885
    [Phe3,Leu13]motilin (human)
    AgonistFull agonist8.910381885

    8 Novoseek inferred chemical compound relationships for MLNR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythromycin 86.7 68 16076462 (4), 18096134 (3), 10065328 (3), 17870192 (2) (see all 45)
    em574 85.4 5 7965757 (3), 10574195 (2)
    em 523 85.3 3 9203450 (1), 15764739 (1)
    cisapride 70 1 17934842 (1)
    aequorin 43.2 2 11779105 (2)
    calcium 13.5 9 18433751 (2), 8277775 (1), 11461914 (1), 11813507 (1) (see all 6)
    alanine 0 2 16531413 (1), 18032475 (1)
    dopamine 0 1 10697661 (1)

    Search CenterWatch for drugs/clinical trials and news about MLNR / MTLR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MLNR gene: 
    NM_001507.1  

    Unigene Cluster for MLNR:

    Motilin receptor
    Hs.248126  [show with all ESTs]
    Unigene Representative Sequence: NM_001507
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218721(uc010tgj.2) ENST00000398307
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MLNR
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MLNR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MLNR
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    OriGene clones in human, mouse for MLNR (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLNR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLNR
    Sirion Biotech Customized lentivirus for stable overexpression of MLNR 
                         Customized lentivirus expression plasmids for stable overexpression of MLNR 
    Primer
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    OriGene qPCR primer pairs and template standards for MLNR
    OriGene qSTAR qPCR primer pairs in human, mouse for MLNR
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLNR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLNR

    Additional mRNA sequence: AY603964.1 

    2 DOTS entries:

    DT.91969157  DT.91687070 

    3 AceView cDNA sequences:

    AY603964 NM_001507 BU553576 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MLNR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGGGTCA
    MLNR Expression
    About this image


    See MLNR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MLNR

    SOURCE GeneReport for Unigene cluster: Hs.248126

    UniProtKB/Swiss-Prot: MTLR_HUMAN, O43193
    Tissue specificity: Expressed only in thyroid, stomach, and bone marrow

        SABiosciences Custom PCR Arrays for MLNR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLNR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MLNR gene from 6/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia MLNR1 motilin receptor 84.88(n)
    81.96(a)
      608252  NM_001128064.1  NP_001121536.1 
    chicken
    (Gallus gallus)
    Aves MLNR1 motilin receptor 73.63(n)
    70.59(a)
      428072  NM_001127313.1  NP_001120785.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLNR6
    --
    --
    61(a)
    43(a)
    1 ↔ 1
    possible ortholog
    1(124035902-124037463)
    GL343202.1(2239627-2260118)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005364061 growth hormone secretagogue receptor type 1-like 59.78(n)
    54.75(a)
      100536406  XM_003199998.1  XP_003200046.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ETHR6
    ETHR
    18(a)
    possible ortholog
    3R(17073026-17090856)
    worm
    (Caenorhabditis elegans)
    Secernentea npr-156
    npr-336
    Protein NPR-33
    19(a)
    16(a)
    possible ortholog
    possible ortholog
    III(3683256-3685808)
    X(15910638-15914159)


    ENSEMBL Gene Tree for MLNR (if available)
    TreeFam Gene Tree for MLNR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MLNR gene
    GHSR2  NTSR12  GPR392  NMUR12  NMUR22  TRHR2  NTSR22  
    4 SIMAP similar genes for MLNR using alignment to 1 protein entry:     MTLR_HUMAN:
    GHSR    NMUR2    NTSR1    NMUR1

    MLNR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 SNPs in MLNR are shown (see all 135)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466686431,2
    --30736939(+) GCAAGA/GGACCG 1 -- us2k10--------
    rs1810601831,2
    --30736956(+) GGAAGA/GAGGAG 1 -- us2k10--------
    rs1863045811,2
    --30737114(+) TTCCGG/TCGACA 1 -- us2k10--------
    rs1402166191,2
    C--30737281(+) GACCAC/TGGAGG 1 -- us2k10--------
    rs1132961071,2
    C--30737326(+) AAACAA/GCAGCG 1 -- us2k10--------
    rs1903675321,2
    --30737808(+) CATAAC/GAATGA 1 -- us2k10--------
    rs1829453681,2
    --30737818(+) ACATAA/TCACAT 1 -- us2k10--------
    rs1875730491,2
    C--30737820(+) ATATCA/GCATGT 1 -- us2k10--------
    rs1480018051,2
    --30737861(+) GTCTTA/GTTCTT 1 -- us2k10--------
    rs1908741411,2
    --30738106(+) AGGACC/TGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MLNR (49794474 - 49796513 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MLNR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832607CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MLNR
    DNA2.0 Custom Variant and Variant Library Synthesis for MLNR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602885    OMIM disorders: --

    19 diseases for MLNR:    About MalaCards
    colonic pseudo-obstruction    diabetic autonomic neuropathy    gastroparesis    dyspepsia
    constipation    gastroduodenitis    ileus    irritable bowel syndrome
    autonomic neuropathy    intestinal pseudo-obstruction    type 1 diabetes mellitus    type 1 diabetes
    neuropathy    hyperparathyroidism    blindness    diabetes mellitus
    esophagitis    thyroiditis    pancreatitis

    4 diseases from the University of Copenhagen DISEASES database for MLNR:
    Gastroparesis     Ileus     Dyspepsia     Functional colonic disease

    MLNR for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for MLNR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic gastroparesis 88.1 5 19345243 (1), 1537520 (1), 2130582 (1), 1727784 (1) (see all 5)
    gastroparesis 80.8 2 8299441 (1), 10697661 (1)
    motility disorder 67.5 6 7604665 (1), 18185063 (1), 9027652 (1), 16699856 (1) (see all 5)
    hypomotility 67 5 18420306 (1), 18096134 (1)
    functional dyspepsia 66.8 2 19345243 (1), 11121915 (1)
    diabetic autonomic neuropathy 52.3 1 8299441 (1)
    gall bladder 25.7 3 8174966 (1), 9691922 (1)
    reflux 11.5 1 11929393 (1)
    diabetes mellitus insulin-dependent 1.49 1 11511562 (1)

    Genetic Association Database (GAD): MLNR
    Human Genome Epidemiology (HuGE) Navigator: MLNR (1 document)

    Export disorders for MLNR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MLNR gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with MLNR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. (PubMed id 9441746)1, 2, 3 McKee K.K.... van der Ploeg L.H.T. (1997)
    2. Growth hormone secretagogue receptor family members and ligands. (PubMed id 11322507)1, 2, 9 Smith R.G.... Howard A.D. (2001)
    3. Receptor for motilin identified in the human gastrointestinal system. (PubMed id 10381885)1, 2, 9 Feighner S.D....Howard A.D. (1999)
    4. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    6. Motilin receptors in the human antrum. (PubMed id 10644557)1, 9 Miller P....Poitras P. (2000)
    7. Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail. (PubMed id 18420306)1, 9 Mitselos A....Depoortere I. (2008)
    8. Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine. (PubMed id 18183601)1, 9 Ter Beek W.P....Lamers C.B. (2008)
    9. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. (PubMed id 11461914)1, 9 Coulie B....Miller L.J. (2001)
    10. Demonstration of a functional motilin receptor in TE671 cells from human cerebellum. (PubMed id 11259768)1, 9 Thielemans L....Peeters T.L. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2862 HGNC: 4495 AceView: MLNR Ensembl:ENSG00000102539 euGenes: HUgn2862
    ECgene: MLNR Kegg: 2862 H-InvDB: MLNR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MLNR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MLNR gene:
    Search GeneIP for patents involving MLNR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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