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Aliases for MLN Gene

Aliases for MLN Gene

  • Motilin 2 3
  • Prepromotilin 2 3

External Ids for MLN Gene

Previous GeneCards Identifiers for MLN Gene

  • GC06M033764
  • GC06M033809
  • GC06M033870
  • GC06M033504

Summaries for MLN Gene

Entrez Gene Summary for MLN Gene

  • This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for MLN Gene

MLN (Motilin) is a Protein Coding gene. Diseases associated with MLN include gastroparesis and duodenogastric reflux. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for MLN Gene

  • Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLN Gene

Genomics for MLN Gene

Regulatory Elements for MLN Gene

Genomic Location for MLN Gene

Chromosome:
6
Start:
33,794,672 bp from pter
End:
33,804,016 bp from pter
Size:
9,345 bases
Orientation:
Minus strand

Genomic View for MLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLN Gene

Proteins for MLN Gene

  • Protein details for MLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12872-MOTI_HUMAN
    Recommended name:
    Promotilin
    Protein Accession:
    P12872
    Secondary Accessions:
    • B7ZLR7
    • E9PDN2
    • J3KN51
    • Q2M1L2
    • Q5T975
    • Q6NSY7

    Protein attributes for MLN Gene

    Size:
    115 amino acids
    Molecular mass:
    12920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MLN Gene

    Alternative splice isoforms for MLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLN Gene

Proteomics data for MLN Gene at MOPED

Post-translational modifications for MLN Gene

No Post-translational modifications

Other Protein References for MLN Gene

Antibody Products

No data available for DME Specific Peptides for MLN Gene

Domains & Families for MLN Gene

Gene Families for MLN Gene

Protein Domains for MLN Gene

Suggested Antigen Peptide Sequences for MLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12872

UniProtKB/Swiss-Prot:

MOTI_HUMAN :
  • Belongs to the motilin family.
Family:
  • Belongs to the motilin family.
genes like me logo Genes that share domains with MLN: view

Function for MLN Gene

Molecular function for MLN Gene

GENATLAS Biochemistry:
motilin,regulator of gastrointestinal motility,secreted by enterochromaffin cells of the duodenum and small intestine,also expressed in brain and bronchi. Affects gastric motility by stimulating interdigestive antrum and duodenal contractions
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle

Gene Ontology (GO) - Molecular Function for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10381885
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with MLN: view

Phenotypes for MLN Gene

GenomeRNAi human phenotypes for MLN:
genes like me logo Genes that share phenotypes with MLN: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MLN Gene

Localization for MLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLN Gene COMPARTMENTS Subcellular localization image for MLN gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with MLN: view

Pathways & Interactions for MLN Gene

genes like me logo Genes that share pathways with MLN: view

SIGNOR curated interactions for MLN Gene

Activates:

Gene Ontology (GO) - Biological Process for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10381885
GO:0007267 cell-cell signaling TAS 10381885
genes like me logo Genes that share ontologies with MLN: view

Drugs & Compounds for MLN Gene

(42) Drugs for MLN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 799
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Azithromycin Approved Pharma 309
Bethanechol Approved Pharma Full agonist, Agonist 3
cholestyramine Approved Pharma 0

(8) Additional Compounds for MLN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
AEQUORIN
caerulein
Cyanogen bromide
EM 523
genes like me logo Genes that share compounds with MLN: view

Transcripts for MLN Gene

mRNA/cDNA for MLN Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLN Gene

Motilin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLN Gene

No ASD Table

Relevant External Links for MLN Gene

GeneLoc Exon Structure for
MLN
ECgene alternative splicing isoforms for
MLN

Expression for MLN Gene

mRNA expression in normal human tissues for MLN Gene

mRNA differential expression in normal tissues according to GTEx for MLN Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x40.1).

SOURCE GeneReport for Unigene cluster for MLN Gene Hs.2813

genes like me logo Genes that share expression patterns with MLN: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MLN Gene

Orthologs for MLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MLN 35
  • 84.71 (n)
  • 81.48 (a)
MLN 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLN 35
  • 83.5 (n)
  • 77.78 (a)
MLN 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MLN 35
  • 98.55 (n)
  • 98.26 (a)
MLN 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLN 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLN 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLN 36
  • 46 (a)
OneToOne
Species with no ortholog for MLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MLN Gene

ENSEMBL:
Gene Tree for MLN (if available)
TreeFam:
Gene Tree for MLN (if available)

Paralogs for MLN Gene

No data available for Paralogs for MLN Gene

Variants for MLN Gene

Sequence variations from dbSNP and Humsavar for MLN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2281816 -- 33,804,558(-) TACAC(C/T)GTCAC upstream-variant-2KB
rs2281817 -- 33,804,191(-) ACTGT(C/T)GCTGT upstream-variant-2KB
rs2281818 -- 33,804,002(-) CACCA(A/G)AAGAC utr-variant-5-prime
rs2281819 -- 33,803,896(-) AGCAG(A/T)ACGCT intron-variant
rs3763253 -- 33,804,984(+) TTAGA(A/G)TGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MLN Gene

Variant ID Type Subtype PubMed ID
nsv885772 CNV Loss 21882294
nsv509128 CNV Insertion 20534489

Variation tolerance for MLN Gene

Residual Variation Intolerance Score: 66.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLN Gene

HapMap Linkage Disequilibrium report
MLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLN Gene

Disorders for MLN Gene

MalaCards: The human disease database

(14) MalaCards diseases for MLN Gene - From: DISEASES, NovoSeek, and GeneCards

- elite association
Search MLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for MLN

Genetic Association Database (GAD)
MLN
Human Genome Epidemiology (HuGE) Navigator
MLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLN
genes like me logo Genes that share disorders with MLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLN Gene

Publications for MLN Gene

  1. Covariation of plasma ghrelin and motilin in irritable bowel syndrome. (PMID: 20338210) SjAPlund K. … Wierup N. (Peptides 2010) 23 67
  2. House musk shrew (Suncus murinus, order: Insectivora) as a new model animal for motilin study. (PMID: 18996160) Tsutsui C. … Sakai T. (Peptides 2009) 23 67
  3. Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus. (PMID: 19782932) Pendleton H. … Ohlsson B. (Eur. J. Intern. Med. 2009) 23 67
  4. Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. (PMID: 17582410) Olsson C. … Andrews P.L. (Gen. Comp. Endocrinol. 2008) 23 67
  5. Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking. (PMID: 18096134) Mitselos A. … Depoortere I. (Biochem. Pharmacol. 2008) 23 67

Products for MLN Gene

Sources for MLN Gene

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