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Aliases for MLN Gene

Aliases for MLN Gene

  • Motilin 2 3
  • Prepromotilin 2 3
  • Promotilin 3

External Ids for MLN Gene

Previous GeneCards Identifiers for MLN Gene

  • GC06M033764
  • GC06M033809
  • GC06M033870
  • GC06M033504

Summaries for MLN Gene

Entrez Gene Summary for MLN Gene

  • This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for MLN Gene

MLN (Motilin) is a Protein Coding gene. Diseases associated with MLN include paralytic ileus and gastric outlet obstruction. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for MLN Gene

  • Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLN Gene

Genomics for MLN Gene

Regulatory Elements for MLN Gene

Genomic Location for MLN Gene

33,794,672 bp from pter
33,804,016 bp from pter
9,345 bases
Minus strand

Genomic View for MLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLN Gene

Proteins for MLN Gene

  • Protein details for MLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7ZLR7
    • E9PDN2
    • J3KN51
    • Q2M1L2
    • Q5T975
    • Q6NSY7

    Protein attributes for MLN Gene

    115 amino acids
    Molecular mass:
    12920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MLN Gene

    Alternative splice isoforms for MLN Gene


neXtProt entry for MLN Gene

Proteomics data for MLN Gene at MOPED

Post-translational modifications for MLN Gene

No Post-translational modifications

Other Protein References for MLN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MLN Gene

Domains for MLN Gene

Gene Families for MLN Gene


Protein Domains for MLN Gene

Suggested Antigen Peptide Sequences for MLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12872
  • Belongs to the motilin family.
genes like me logo Genes that share domains with MLN: view

Function for MLN Gene

Molecular function for MLN Gene

GENATLAS Biochemistry: motilin,regulator of gastrointestinal motility,secreted by enterochromaffin cells of the duodenum and small intestine,also expressed in brain and bronchi. Affects gastric motility by stimulating interdigestive antrum and duodenal contractions
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle

Gene Ontology (GO) - Molecular Function for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10381885
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with MLN: view

Animal Model Products

miRNA for MLN Gene

miRTarBase miRNAs that target MLN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLN Gene

Localization for MLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLN Gene


Subcellular locations from

Jensen Localization Image for MLN Gene COMPARTMENTS Subcellular localization image for MLN gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with MLN: view

Pathways for MLN Gene

genes like me logo Genes that share pathways with MLN: view

Gene Ontology (GO) - Biological Process for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10381885
GO:0007267 cell-cell signaling TAS 10381885
genes like me logo Genes that share ontologies with MLN: view

Compounds for MLN Gene

(50) Novoseek inferred chemical compound relationships for MLN Gene

Compound -log(P) Hits PubMed IDs
erythromycin 84.2 114
erythromycin lactobionate 79.4 1
em 523 79.2 2
oxyntomodulin 78.8 7
cisapride 70.9 6
genes like me logo Genes that share compounds with MLN: view

Transcripts for MLN Gene

mRNA/cDNA for MLN Gene

(10) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLN Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MLN
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLN Gene

No ASD Table

Relevant External Links for MLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLN Gene

mRNA expression in normal human tissues for MLN Gene

mRNA differential expression in normal tissues according to GTEx for MLN Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (40.1).

SOURCE GeneReport for Unigene cluster for MLN Gene Hs.2813

genes like me logo Genes that share expressions with MLN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MLN Gene

Orthologs for MLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MLN 35
  • 98.55 (n)
  • 98.26 (a)
MLN 36
  • 98 (a)
(Bos Taurus)
Mammalia MLN 35
  • 84.71 (n)
  • 81.48 (a)
MLN 36
  • 77 (a)
(Canis familiaris)
Mammalia MLN 35
  • 83.5 (n)
  • 77.78 (a)
MLN 36
  • 71 (a)
(Monodelphis domestica)
Mammalia MLN 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia MLN 36
  • 61 (a)
(Gallus gallus)
Aves MLN 36
  • 46 (a)
Species with no ortholog for MLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MLN Gene

Gene Tree for MLN (if available)
Gene Tree for MLN (if available)

Paralogs for MLN Gene

No data available for Paralogs for MLN Gene

Variants for MLN Gene

Sequence variations from dbSNP and Humsavar for MLN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs751726 -- 33,796,609(-) GAGCC(C/T)GGTGG intron-variant
rs751727 -- 33,796,381(-) GTGGT(C/T)GTGGG intron-variant
rs751728 -- 33,796,256(-) AAAAT(A/G)GGAAC intron-variant
rs873744 -- 33,796,340(-) taccg(A/T)cttct intron-variant
rs943461 -- 33,801,632(+) ATGAC(C/G)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLN Gene

Variant ID Type Subtype PubMed ID
nsv885772 CNV Loss 21882294
nsv509128 CNV Insertion 20534489

Relevant External Links for MLN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLN Gene

Disorders for MLN Gene

(34) Novoseek inferred disease relationships for MLN Gene

Disease -log(P) Hits PubMed IDs
diabetic gastroparesis 86.8 8
gastroparesis 84.4 6
motility disorder 77.4 6
hypomotility 77.3 3
gastric atony 70.7 2

Relevant External Links for MLN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MLN: view

No data available for UniProtKB/Swiss-Prot for MLN Gene

Publications for MLN Gene

  1. The motilin gene: subregional localisation, tissue expression, DNA polymorphisms and exclusion as a candidate gene for the HLA-associated immotile cilia syndrome. (PMID: 7989042) Gasparini P. … Zelante L. (Hum. Genet. 1994) 3 23 48
  2. Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis. (PMID: 18358279) Svenningsson A. … NordenskjAPld A. (J. Pediatr. Surg. 2008) 3 23 48
  3. Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine. (PMID: 17595255) Wierup N. … SjAPlund K. (J. Clin. Endocrinol. Metab. 2007) 3 23
  4. Covariation of plasma ghrelin and motilin in irritable bowel syndrome. (PMID: 20338210) SjAPlund K. … Wierup N. (Peptides 2010) 3 23
  5. Structure and expression of the human motilin gene. (PMID: 2574660) Daikh D.I. … Adelman J.P. (DNA 1989) 3 4

Products for MLN Gene

Sources for MLN Gene

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