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MLN Gene

protein-coding   GIFtS: 54
GCID: GC06M033762

Motilin

  See MLN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
motilin1 2
prepromotilin1 2
promotilin2

External Ids:    HGNC: 71411   Entrez Gene: 42952   Ensembl: ENSG000000963957   OMIM: 1582705   UniProtKB: P128723   

Export aliases for MLN gene to outside databases

Previous GC identifers: GC06M033764 GC06M033809 GC06M033870 GC06M033504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MLN Gene:
This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate
gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature
peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding
different preproprotein isoforms but the same mature peptide have been found for this gene. (provided by RefSeq,
May 2010)

GeneCards Summary for MLN Gene:
MLN (motilin) is a protein-coding gene. Diseases associated with MLN include paralytic ileus, and gastric outlet obstruction. GO annotations related to this gene include hormone activity and receptor binding.

UniProtKB/Swiss-Prot: MOTI_HUMAN, P12872
Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly
causes rhythmic contraction of duodenal and colonic smooth muscle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLN gene promoter:
         MEF-2A   NRSF form 1   aMEF-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLN promoter sequence
   Search Chromatin IP Primers for MLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

MLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033762:  view genomic region     (about GC identifiers)

Start:
33,762,449 bp from pter      End:
33,771,793 bp from pter
Size:
9,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOTI_HUMAN, P12872 (See protein sequence)
Recommended Name: Promotilin precursor  
Size: 115 amino acids; 12920 Da
1 PDB 3D structure from and Proteopedia for MLN:
1LBJ (3D)    
Secondary accessions: B7ZLR7 E9PDN2 J3KN51 Q2M1L2 Q5T975 Q6NSY7
Alternative splicing: 3 isoforms:  P12872-1   P12872-2   P12872-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLN: NX_P12872

Explore proteomics data for MLN at MOPED


See MLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001035198.1  NP_001171627.1  NP_002409.1  

ENSEMBL proteins: 
 ENSP00000388825   ENSP00000266003   ENSP00000425467  
Reactome Protein details: P12872

MLN Human Recombinant Protein Products:

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Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for MLN 

 
antibodies-online proteins for MLN (21 products) 

 
antibodies-online peptides for MLN

MLN Antibody Products:

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antibodies-online antibodies for MLN (36 products) 

MLN Assay Products:

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antibodies-online kits for MLN (40 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR006738 Motilin_ghrelin
 IPR015662 Motilin
 IPR006737 Motilin_assoc

Graphical View of Domain Structure for InterPro Entry P12872

ProtoNet protein and cluster: P12872

1 Blocks protein domain: IPB006738 Motilin/ghrelin

UniProtKB/Swiss-Prot: MOTI_HUMAN, P12872
Similarity: Belongs to the motilin family


Find genes that share domains with MLN           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MOTI_HUMAN, P12872
Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly
causes rhythmic contraction of duodenal and colonic smooth muscle

     Genatlas biochemistry entry for MLN:
motilin,regulator of gastrointestinal motility,secreted by enterochromaffin cells of the duodenum and small
intestine,also expressed in brain and bronchi. Affects gastric motility by stimulating interdigestive antrum and
duodenal contractions

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS10381885
GO:0005179hormone activity IEA--
     
Find genes that share ontologies with MLN           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLN
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLN

miRNA
Products:
    
miRTarBase miRNAs that target MLN:
hsa-mir-335-5p (MIRT018464)

Block miRNA regulation of human, mouse, rat MLN using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate MLN:
hsa-miR-1287
SwitchGear 3'UTR luciferase reporter plasmidMLN 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MLN

Gene Editing
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GenScript: all cDNA clones in your preferred vector: MLN (NM_001507)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLN

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MOTI_HUMAN, P12872: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
endoplasmic reticulum1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

Find genes that share ontologies with MLN           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MLN About    
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90


Find genes that share SuperPaths with MLN           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Reactome Pathways for MLN
    Peptide ligand-binding receptors
G alpha (q) signalling events


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLN
Interactions:

    GeneGlobe Interaction Network for MLN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MLN (P128723 ENSP000002660034) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
InteractantInteraction Details
GeneCardExternal ID(s)
MLNRO431933, ENSP000002187214I2D: score=1 STRING: ENSP00000218721
APPENSP000002849814STRING: ENSP00000284981
CCKENSP000003356574STRING: ENSP00000335657
CCKARENSP000002955894STRING: ENSP00000295589
EDNRAENSP000003150114STRING: ENSP00000315011
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway TAS10381885
GO:0007267cell-cell signaling TAS10381885

Find genes that share ontologies with MLN           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MLN (MOTI)

Selected Novoseek inferred chemical compound relationships for MLN gene (see all 50)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
erythromycin 84.2 130 16076462 (7), 18096134 (5), 1425065 (4), 11169123 (4) (see all 78)
erythromycin lactobionate 79.4 1 1296862 (1)
em 523 79.2 2 2381873 (1), 8508696 (1)
oxyntomodulin 78.8 7 8359644 (2), 8899078 (1), 8095927 (1), 1735334 (1) (see all 6)
cisapride 70.9 6 9413048 (4), 11917722 (1), 8503391 (1)
dexloxiglumide 63.3 1 16185302 (1)
domperidone 59.6 3 16141553 (3)
lafutidine 57.5 2 11913538 (2)
metoclopramide 55.6 2 18321441 (1), 1987856 (1)
prucalopride 53.9 2 11438309 (2)



Find genes that share compounds with MLN           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MLN gene (3 alternative transcripts): 
NM_001040109.1  NM_001184698.1  NM_002418.2  

Unigene Cluster for MLN:

Motilin
Hs.2813  [show with all ESTs]
Unigene Representative Sequence: NM_002418
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000430124(uc003ofg.1 uc003off.1 uc011drn.1) ENST00000266003
ENST00000507738
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MLN using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate MLN:
hsa-miR-1287
SwitchGear 3'UTR luciferase reporter plasmidMLN 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MLN
Predesigned siRNA for gene silencing in human, mouse, rat MLN
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MLN (NM_001507)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLN
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for MLN
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MLN
  QuantiTect SYBR Green Assays in human, mouse, rat MLN
  QuantiFast Probe-based Assays in human, mouse, rat MLN

Additional mRNA sequence: 

BC069675.1 BC112314.1 BC143981.1 Y00695.1 

1 DOTS entry:

DT.105949 

10 AceView cDNA sequences:

AI655747 BX100277 Y00695 BC069675 NM_002418 BM855295 BM855669 AI824815 
AW014210 AI824827 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MLN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MLN Expression
About this image

MLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MLN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2813
    Custom PCR Arrays for MLN
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MLN gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia MLN1 motilin 83.5(n)
77.78(a)
  481748  XM_005627225.1  XP_005627282.1 
chicken
(Gallus gallus)
Aves MLN6
Motilin
46(a)
1 ↔ 1
26(4515351-4518565)


ENSEMBL Gene Tree for MLN (if available)
TreeFam Gene Tree for MLN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MLN (see all 286)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1903492331,2
--33761979(+) ACAAGA/GTGCTA 3 -- ds50010--------
rs1487976741,2
--33761981(+) AAGGTA/GCTAAT 3 -- ds50010--------
rs568412791,2
C--33762053(+) TTTTGC/TACAGG 3 -- ds50012Minor allele frequency- T:0.10WA 120
rs13597811,2
C,F,O,A,H--33762104(+) GGGGTC/TGAGTG 3 -- ds500125Minor allele frequency- G:0.02EA NA NS WA CSA 1420
rs1132125561,2
F--33762194(+) GAATTG/CCAGTC 3 -- ds50011Minor allele frequency- C:0.00CSA 1
rs22744591,2
C,F,H--33762242(+) GATCAG/ATTTCC 3 -- ds500126Minor allele frequency- A:0.08NS EA NA 3070
rs1468595121,2
--33762387(+) TTCCCC/GCCCTT 3 -- ds50010--------
rs749690611,2
C,F--33762451(+) TTTCTG/ATATAT 3 -- ut311Minor allele frequency- A:0.04NA 120
rs1179779041,2
C,F--33762477(+) CTGGAG/CGGGAA 3 -- ut311Minor allele frequency- C:0.01EA 120
rs1113963691,2
C,F--33762545(+) CAGGGC/ACTCAC 3 -- ut312Minor allele frequency- A:0.00CSA EU 501

HapMap Linkage Disequilibrium report for MLN (33762449 - 33771793 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MLN:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509128CNV Insertion20534489
nsv885772CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MLN
DNA2.0 Custom Variant and Variant Library Synthesis for MLN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 158270    OMIM disorders: --

10 diseases for MLN:    
About MalaCards
paralytic ileus    gastric outlet obstruction    duodenogastric reflux    diabetic autonomic neuropathy
dumping syndrome    zollinger-ellison syndrome    hyperglycemia    pheochromocytoma
type 1 diabetes mellitus    obesity

10 diseases from the University of Copenhagen DISEASES database for MLN:
Gastroparesis     Ileus     Dyspepsia     Constipation
Irritable bowel syndrome     Dumping syndrome     Diarrhea     Gastric outlet obstruction
Gastroesophageal reflux disease     Autonomic neuropathy

Find genes that share disorders with MLN           About GenesLikeMe

Selected Novoseek inferred disease relationships for MLN gene (see all 34)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic gastroparesis 86.8 9 1727784 (3), 1991439 (2), 1537520 (1), 18721079 (1) (see all 5)
gastroparesis 84.4 6 17894654 (1), 11071469 (1), 17011824 (1), 17934842 (1) (see all 6)
motility disorder 77.4 6 8938905 (1), 1413940 (1), 10959771 (1), 11438309 (1) (see all 6)
hypomotility 77.3 3 8313742 (1), 11169123 (1), 19864732 (1)
gastric atony 70.7 2 8103982 (1), 16495694 (1)
gastric motility disorder 66.5 2 18321441 (1), 12600114 (1)
functional dyspepsia 64.9 6 15043521 (3), 12519743 (2), 17934842 (1)
infantile colic 62.2 6 16754557 (2), 2349877 (2), 15466076 (1)
gastroesophageal reflux disease 46.4 5 12182748 (1), 9413048 (1), 8311131 (1), 11182403 (1) (see all 5)
autonomic neuropathy 45.5 3 1425065 (2), 8503391 (1)

Genetic Association Database (GAD): MLN
Human Genome Epidemiology (HuGE) Navigator: MLN (3 documents)

Export disorders for MLN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MLN gene, integrated from 10 sources (see all 353):
(articles sorted by number of sources associating them with MLN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The motilin gene: subregional localisation, tissue expression, DNA polymorphisms and exclusion as a candidate gene for the HLA-associated immotile cilia syndrome. (PubMed id 7989042)1, 4, 9 Gasparini P....Zelante L. (Hum. Genet. 1994)
  2. Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis. (PubMed id 18358279)1, 4, 9 Svenningsson A....NordenskjAPld A. (J. Pediatr. Surg. 2008)
  3. Genome-wide association analysis of age-at-onset in Alzheimer's disease. (PubMed id 22005931)1, 4 Kamboh M.I....Lopez O.L. (Mol. Psychiatry 2012)
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
  5. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
  6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Structure and expression of the human motilin gene. (PubMed id 2574660)1, 2 Daikh D.I.... Adelman J.P. (DNA 1989)
  9. Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin. (PubMed id 2914635)1, 2 Dea D.... Lahaie R.G. (Gastroenterology 1989)
  10. Exon-intron organization, expression, and chromosomal localization of the human motilin gene. (PubMed id 2737284)1, 2 Yano H.... Imura H. (FEBS Lett. 1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4295 HGNC: 7141 AceView: MLN Ensembl:ENSG00000096395 euGenes: HUgn4295
ECgene: MLN H-InvDB: MLN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MLN Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Motilin

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MLN gene:
Search GeneIP for patents involving MLN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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