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Aliases for MLN Gene

Aliases for MLN Gene

  • Motilin 2 3 5
  • Prepromotilin 2 3
  • Promotilin 3

External Ids for MLN Gene

Previous GeneCards Identifiers for MLN Gene

  • GC06M033764
  • GC06M033809
  • GC06M033870
  • GC06M033504

Summaries for MLN Gene

Entrez Gene Summary for MLN Gene

  • This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for MLN Gene

MLN (Motilin) is a Protein Coding gene. Diseases associated with MLN include Gastroparesis and Duodenogastric Reflux. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for MLN Gene

  • Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Additional gene information for MLN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLN Gene

Genomics for MLN Gene

Regulatory Elements for MLN Gene

Enhancers for MLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H033767 1.5 Ensembl ENCODE dbSUPER 11.6 +33.4 33414 5 PKNOX1 ATF1 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 ATF7 RUNX3 REST LEMD2 RING1 MLN IP6K3 GRM4 GGNBP1 RPS18 UQCC2 BAK1
GH06H033761 1.5 Ensembl ENCODE dbSUPER 11.1 +41.8 41803 0 HDGF PKNOX1 MLX ARID4B YY1 GLIS2 ZNF143 ATF7 DEK ZHX2 LEMD2 UQCC2 IP6K3 MLN GGNBP1 BAK1 HLA-DPA1
GH06H034129 1.3 FANTOM5 ENCODE dbSUPER 10.7 -326.8 -326836 3 MAX ZNF175 ZIC2 ETS1 SLC30A9 ZNF766 FOS ZNF584 ZNF3 SMARCC1 GRM4 IP6K3 LEMD2 MLN PIR53321
GH06H034132 1.2 ENCODE dbSUPER 10.7 -328.7 -328713 0 ELF3 ARID4B SIN3A DNMT3B ZSCAN9 RARA CHAMP1 SLC30A9 ZNF766 ZNF143 GRM4 IP6K3 LEMD2 MLN PIR53321
GH06H034145 1.1 ENCODE dbSUPER 10.9 -341.7 -341683 0 CTCF MXI1 KLF1 MAX SIN3A ZFHX2 CTBP1 GLIS2 ZNF366 POLR2A MLN LEMD2 GRM4 PIR53321
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MLN on UCSC Golden Path with GeneCards custom track

Genomic Location for MLN Gene

Chromosome:
6
Start:
33,794,672 bp from pter
End:
33,804,016 bp from pter
Size:
9,345 bases
Orientation:
Minus strand

Genomic View for MLN Gene

Genes around MLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLN Gene

Proteins for MLN Gene

  • Protein details for MLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12872-MOTI_HUMAN
    Recommended name:
    Promotilin
    Protein Accession:
    P12872
    Secondary Accessions:
    • B7ZLR7
    • E9PDN2
    • J3KN51
    • Q2M1L2
    • Q5T975
    • Q6NSY7

    Protein attributes for MLN Gene

    Size:
    115 amino acids
    Molecular mass:
    12920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MLN Gene

    Alternative splice isoforms for MLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLN Gene

Post-translational modifications for MLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLN Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MLN

Protein Products

  • R&D Systems Peptides for MLN (Motilin)

No data available for DME Specific Peptides for MLN Gene

Domains & Families for MLN Gene

Gene Families for MLN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for MLN Gene

Suggested Antigen Peptide Sequences for MLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12872

UniProtKB/Swiss-Prot:

MOTI_HUMAN :
  • Belongs to the motilin family.
Family:
  • Belongs to the motilin family.
genes like me logo Genes that share domains with MLN: view

Function for MLN Gene

Molecular function for MLN Gene

GENATLAS Biochemistry:
motilin,regulator of gastrointestinal motility,secreted by enterochromaffin cells of the duodenum and small intestine,also expressed in brain and bronchi. Affects gastric motility by stimulating interdigestive antrum and duodenal contractions
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Phenotypes From GWAS Catalog for MLN Gene

Gene Ontology (GO) - Molecular Function for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10381885
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with MLN: view
genes like me logo Genes that share phenotypes with MLN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MLN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLN Gene

Localization for MLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLN gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with MLN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MLN Gene

Pathways & Interactions for MLN Gene

genes like me logo Genes that share pathways with MLN: view

SIGNOR curated interactions for MLN Gene

Activates:

Gene Ontology (GO) - Biological Process for MLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10381885
GO:0007267 cell-cell signaling TAS 10381885
genes like me logo Genes that share ontologies with MLN: view

Drugs & Compounds for MLN Gene

(44) Drugs for MLN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for MLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MLN: view

Transcripts for MLN Gene

mRNA/cDNA for MLN Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MLN Gene

Motilin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MLN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MLN Gene

No ASD Table

Relevant External Links for MLN Gene

GeneLoc Exon Structure for
MLN
ECgene alternative splicing isoforms for
MLN

Expression for MLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLN Gene

mRNA differential expression in normal tissues according to GTEx for MLN Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x40.1).

NURSA nuclear receptor signaling pathways regulating expression of MLN Gene:

MLN

SOURCE GeneReport for Unigene cluster for MLN Gene:

Hs.2813

Evidence on tissue expression from TISSUES for MLN Gene

  • Nervous system(4.4)
  • Intestine(3.9)
  • Stomach(2.9)
  • Gall bladder(2.6)
  • Blood(2.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MLN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLN Gene

Orthologs for MLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLN 33 34
  • 98.55 (n)
cow
(Bos Taurus)
Mammalia MLN 33 34
  • 84.71 (n)
dog
(Canis familiaris)
Mammalia MLN 33 34
  • 83.5 (n)
oppossum
(Monodelphis domestica)
Mammalia MLN 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLN 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLN 34
  • 46 (a)
OneToOne
Species where no ortholog for MLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MLN Gene

ENSEMBL:
Gene Tree for MLN (if available)
TreeFam:
Gene Tree for MLN (if available)

Paralogs for MLN Gene

No data available for Paralogs for MLN Gene

Variants for MLN Gene

Sequence variations from dbSNP and Humsavar for MLN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000398265 -- 33,795,890(+) TTCTC(A/T)TGGGG intron-variant, upstream-variant-2KB
rs1000814253 -- 33,800,278(+) TAAAG(C/G)GAACC intron-variant
rs1001120703 -- 33,799,917(+) GACAC(A/T)CTTGG intron-variant
rs1001791026 -- 33,801,690(+) CCATT(A/G)CAAAG intron-variant, nc-transcript-variant
rs1001838266 -- 33,799,024(+) TGGCT(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLN Gene

Variant ID Type Subtype PubMed ID
dgv10610n54 CNV loss 21841781
esv3608630 CNV gain 21293372
nsv509128 CNV insertion 20534489

Variation tolerance for MLN Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLN Gene

Disorders for MLN Gene

MalaCards: The human disease database

(15) MalaCards diseases for MLN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastroparesis
  • gastric atonia
duodenogastric reflux
retinitis pigmentosa 69
  • rp69
systemic scleroderma
  • progressive systemic sclerosis
constipation
- elite association - COSMIC cancer census association via MalaCards
Search MLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for MLN

Genetic Association Database (GAD)
MLN
Human Genome Epidemiology (HuGE) Navigator
MLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLN
genes like me logo Genes that share disorders with MLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLN Gene

Publications for MLN Gene

  1. Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis. (PMID: 18358279) Svenningsson A … Nordenskjöld A (Journal of pediatric surgery 2008) 3 22 45 60
  2. The motilin gene: subregional localisation, tissue expression, DNA polymorphisms and exclusion as a candidate gene for the HLA-associated immotile cilia syndrome. (PMID: 7989042) Gasparini P … Zelante L (Human genetics 1994) 3 22 45 60
  3. Genome-wide association analysis of age-at-onset in Alzheimer's disease. (PMID: 22005931) Kamboh MI … Lopez OL (Molecular psychiatry 2012) 3 45 60
  4. Covariation of plasma ghrelin and motilin in irritable bowel syndrome. (PMID: 20338210) Sjölund K … Wierup N (Peptides 2010) 3 22 60
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60

Products for MLN Gene

Sources for MLN Gene

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