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FOXO4 Gene

protein-coding GIFtS: 51

GC0XP070233

forkhead box O4
(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 7, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MLLT7)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AFX ^², ³
AFX1 ^¹, ², ³
MGC120490 ^²
MLLT7 ^², ³
OTTHUMP00000023496 ^²

Descriptions
Fork head domain transcription factor AFX1 ^³
forkhead box O4 ^²
myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 7 ^¹
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 7 ^²
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 ^¹, ²

External Ids
HGNC: 7139¹
Entrez Gene: 4303²
UniProtKB: P98177³
Ensembl: ENSG00000184481⁷

Search outside databases for aliases for FOXO4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177

Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds

to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates

expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated

genes. Also involved in negative regulation of the cell cycle

Gene Wiki entry for FOXO4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1

FOXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP070233: (about GC identifiers)

Start:	70,232,751 bp from pter
End:	70,240,110 bp from pter
Size:	7,360 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177 (See protein sequence)

Recommended Name: Forkhead box protein O4

Size: 505 amino acids; 53684 Da

Subunit: Interacts with CBP, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CBP and deacetylated by

SIRT1. Binding of YWHAZ inhibits DNA-binding

Subcellular location: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to

cytoplasm. Dephosphorylation triggers nuclear translocation

PDB structure from and Proteopedia :

1E17 (3D)

3BPY (3D)

Secondary accessions: O43821 Q13720 Q3KPF1 Q8TDK9

Alternative splicing: 2 isoforms: P98177-1 P98177-2

Post-translational modifications:

Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity.

Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity¹

Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic

localization¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005929.2

ENSEMBL proteins:

ENSP00000382611 ENSP00000363374 ENSP00000342209 ENSP00000363377

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FOXO4, FOXO1 + FOXO3 + FOXO4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16272144
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	16272144

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Antibodies for FOXO4:

	Invitrogen Antibodies for FOXO4
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for FOXO4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FOXO4
	Antibodies from Abcam (FOXO4, FOXO1 + FOXO3 + FOXO4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FOXO4)
	Novus Biologicals Antibodies for FOXO4

Assays for FOXO4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P98177

ProtoNet protein and cluster: P98177

UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177

Similarity: Contains 1 fork-head DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXO4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005938

Applied Biosystems Silencer® siRNAs for FOXO4

Sigma-Aldrich siRNA for FOXO4

Sigma-Aldrich shRNA for FOXO4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005938
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005938
untagged cDNA clones in CMV expression vector (see all 2): NM_005938

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005938

UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177

Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds

to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates

expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated

genes. Also involved in negative regulation of the cell cycle

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Foxo4):

life span-post-weaning/aging

normal

tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	10783894
GO:0008134	transcription factor binding	IPI	16054032
GO:0016563	transcription activator activity	IEA	--
GO:0019899	enzyme binding	IPI	15126506
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for FOXO4 (Your Favorite Gene powered by Ingenuity)

PTEN Signaling
Insulin Receptor Signaling

GeneDecks FOXO4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FOXO4

5/46 Interacting proteins for FOXO4 (ENSP00000363377³) via UniProtKB, MINT, and/or STRING (see all 46 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKT1	ENSP00000270202³	STRING (score=.999)
MAPK8	ENSP00000363291³	STRING (score=.989)
CDKN1B	ENSP00000228872³	STRING (score=.979)
SIRT1	ENSP00000212015³	STRING (score=.974)
GADD45A	ENSP00000360025³	STRING (score=.972)

About this table

5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	IDA	10783894
GO:0006355	regulation of transcription, DNA-dependent	IDA	15126506
GO:0006366	transcription from RNA polymerase II promoter	TAS	10783894
GO:0007049	cell cycle	IEA	--
GO:0007050	cell cycle arrest	IDA	10783894

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FOXO4
UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177

Pharmaceutical: A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187

and Ser-262 have been mutated to alanine may have therapeutic potential in

ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and

tumorigenicity

3 Novoseek chemical compound relationships for FOXO4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wortmannin	53.23	2	10518537 (2)
phosphatidylinositol	46.35	1	10518537 (1)
glycogen	25.75	1	16973122 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXO4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005938

Sigma-Aldrich siRNA for FOXO4

Sigma-Aldrich shRNA for FOXO4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005938

REFSEQ mRNAs for FOXO4 gene:

NM_005938.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005938

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005938
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005938
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005938

Additional cDNA sequence:

AF384029.1 AK300142.1 BC026735.1 BC106761.2 CR595958.1 CR596165.1 CR620527.1 U10072.1

X93996.1

2 DOTS entries:

DT.109928 DT.95141199

24/57 AceView cDNA sequences (see all 57 ):

BP349083 CR596165 AW075830 AW292413 BE732899 AL552503 CR595958 CK430063

T54418 BM724728 AL532357 BQ021921 AW027741 BQ278065 AL541001 BC026735

BM672472 CR620527 BE350669 BE302136 AI761711 AL575789 BE018775 BE302338

Unigene Cluster for FOXO4:

Forkhead box O4

Hs.584654 [show with all ESTs]

Unigene Representative Sequence: NM_005938

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FOXO4

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5
SP1:							-
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for FOXO4

4 Ensembl transcripts including schematic representations:

ENST00000399704 ENST00000374256 ENST00000341558 ENST00000374259

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FOXO4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FOXO4

¹ / ²

4 probe-sets matching FOXO4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36238_at²	U95-A	1	1.00	1.00	0.96	0.85	--	--	--	--	--
46743_s_at²	U95-B	1	1.00	1.00	0.98	1.15	--	--	--	--	--
205451_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
205451_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FOXO4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGCTAGATTG

SOURCE GeneReport for Unigene cluster: Hs.584654
UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Isoform zeta is most abundant in the liver, kidney, and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FOXO4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FOXO4¹	--	forkhead box O4	91.68(n) 92.87(a)	491946 XM_549066.2 XP_549066.2
chimpanzee (Pan troglodytes)	FOXO4¹	--	forkhead box O4	99.01(n) 98.81(a)	473659 XM_001135016.1 XP_001135016.1
cow (Bos taurus)	FOXO4¹	--	forkhead box O4	90.5(n) 89.11(a)	618793 XM_871116.2 XP_876209.2
rat (Rattus norvegicus)	Foxo4¹	--	forkhead box O4	88.36(n) 88.49(a)	302415 XM_228556.4 XP_228556.4
mouse (Mus musculus)	Foxo4^{1, 5}	X (36.00 cM)⁵	forkhead box O4^{1, 5}	88.36(n)¹ 88.69(a)¹	54601¹ NM_018789.1¹ NP_061259.1¹ AB032770⁵ AB221664⁵ (see all 11)

About this table Species with no ortholog for FOXO4

ENSEMBL Gene Tree for FOXO4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FOXO4 gene

FOXO6² FOXO3² FOXO1² FOXO3B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in FOXO4 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 24)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs5980741^1,2	C,F,H	70231144(+)	`aatttG/Tcacag`	1	--	ng5¹		4		EU EA WA	418
--	rs5981070^1,2	A,C	70230895(+)	`aagaaA/Ggaagg`	1	--	ng5¹ tfbs³ trp³		0	--	--	--	--
	rs4503258^1,2	C	70239962(+)	`CTTTGC/TATCGT`	1	--	ut3¹ ese³		0	--	--	--	--
	rs5980742^1,2	A,C,F,H	70238356(+)	`CCTATG/TACCAC`	1	--	int¹		4		EU EA WA	418
	rs12013673^1,2	A,C,F,H	70233824(+)	`CTCAAC/TATTCG`	1	--	int¹		8		EU EA WA NA	605
--	rs12008108^1,2	A,C,F	70234010(+)	`TCCCAG/ATACCT`	1	--	int¹		1		NA	65
	rs5981072^1,2	A,F,H	70236267(+)	`GCAGCC/TGCTTT`	1	--	int¹		4		EU EA WA	418
--	rs4489469^1,2	A	70236714(+)	`AGGAGA/CACGTC`	1	--	int¹		0	--	--	--	--
	rs4259556^1,2	H	70236824(+)	`GGGCAC/TCCCCC`	1	--	int¹		4		EU EA WA	418
--	rs5936624^1,2	--	70230858(+)	`agaaaA/Gagaaa`	1	--	ng5¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for FOXO4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300033

UniProtKB/Swiss-Prot: FOXO4_HUMAN, P98177

A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation

t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein

3 Novoseek disease relationships for FOXO4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acute leukemia	35.21	3	9010221 (3)
cancer	0.00	7	15688030 (2), 11353388 (1), 9010221 (1)
tumors	0.00	4	18648506 (2), 17599731 (1)

About this table

Human Genome Epidemiology Navigator: FOXO4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/52 PubMed articles for FOXO4 gene (see all 52 ):

Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. (PubMed id 7529552)^{2, 3, 4} Parry P.... Evans G. (1994)
Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). (PubMed id 9010221)^{1, 3, 4} Borkhardt A.... Lampert F. (1997)
Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. (PubMed id 15688030)^{1, 3, 4} Yang H.... Lee M.-H. (2005)
Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PubMed id 16054032)^{1, 3, 4} Liu Z.-P.... Olson E.N. (2005)
Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). (PubMed id 11352721)^{1, 3, 4} Weigelt J.... Wikstrom M. (2001)
Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family. (PubMed id 16272144)^{1, 3, 4} Matsuzaki H.... Kikkawa U. (2005)
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. (PubMed id 10518537)^{1, 3, 4} Takaishi H.... Nishizuka Y. (1999)
14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. (PubMed id 16114898)^{3, 4} Obsilova V.... Obsil T. (2005)
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). (PubMed id 15126506)^{3, 4} van der Horst A.... Burgering B.M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4303	HGNC: 7139	AceView: MLLT7	Ensembl:ENSG00000184481	euGenes: HUgn4303
ECgene: FOXO4	H-InvDB: FOXO4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FOXO4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FOXO4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FOXO4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FOXO4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FOXO4		Antibodies for FOXO4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FOXO4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FOXO4

	Recombinant Proteins (FOXO4, FOXO1 + FOXO3 + FOXO4)
	Antibodies (FOXO4, FOXO1 + FOXO3 + FOXO4)

Search OriGene for FOXO4

Search Tocris compounds for FOXO4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FOXO4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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FOXO4 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for FOXO4

Summaries
for FOXO4

Genomic Location
for FOXO4

Proteins
for FOXO4

Protein Domains/
Families
for FOXO4

Gene Function
for FOXO4

Pathways & Interactions
for FOXO4

Drugs & Compounds
for FOXO4

Transcripts
for FOXO4

Expression
for FOXO4

Orthologs
for FOXO4

Paralogs
for FOXO4

SNPs/Variants
for FOXO4

Disorders & Mutations
for FOXO4

Medical News
for FOXO4

Publications
for FOXO4

Search for FOXO4

Genome Databases showing FOXO4

Other Databases showing FOXO4

Specialized Databases showing FOXO4

Licensable Technologies
for FOXO4

Services
for FOXO4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FOXO4 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor FOXO4

Summariesfor FOXO4

Genomic Locationfor FOXO4

Proteinsfor FOXO4

Protein Domains/Familiesfor FOXO4

Gene Functionfor FOXO4

Pathways & Interactionsfor FOXO4

Drugs & Compoundsfor FOXO4

Transcriptsfor FOXO4

Expression for FOXO4

Orthologsfor FOXO4

Paralogsfor FOXO4

SNPs/Variantsfor FOXO4

Disorders & Mutationsfor FOXO4

Medical Newsfor FOXO4

Publicationsfor FOXO4

Search for FOXO4

Genome Databases showing FOXO4

Other Databases showing FOXO4

Specialized Databases showing FOXO4

Licensable Technologiesfor FOXO4

Servicesfor FOXO4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FOXO4

Summaries
for FOXO4

Genomic Location
for FOXO4

Proteins
for FOXO4

Protein Domains/
Families
for FOXO4

Gene Function
for FOXO4

Pathways & Interactions
for FOXO4

Drugs & Compounds
for FOXO4

Transcripts
for FOXO4

Expression
for FOXO4

Orthologs
for FOXO4

Paralogs
for FOXO4

SNPs/Variants
for FOXO4

Disorders & Mutations
for FOXO4

Medical News
for FOXO4

Publications
for FOXO4

Licensable Technologies
for FOXO4

Services
for FOXO4