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MLLT6 Gene

protein-coding   GIFtS: 54
GCID: GC17P036861

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 61 2
     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 61
AF172 3 5     Translocated To1
Trithorax Homolog1 2     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog);
Translocated To, 62
ALL1-Fused Gene From Chromosome 17 Protein2 3     Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Translocated To, 62
61     Protein AF-172
Myeloid/Lymphoid Or Mixed-Lineage Leukemia1     

External Ids:    HGNC: 71381   Entrez Gene: 43022   Ensembl: ENSG000001082927   OMIM: 6003285   UniProtKB: P551983   

Export aliases for MLLT6 gene to outside databases

Previous GC identifers: GC17P036347 GC17P038855 GC17P036772 GC17P037236 GC17P034115 GC17P032658


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MLLT6 Gene:
MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6) is a protein-coding gene. Diseases associated with MLLT6 include acute monocytic leukemia, and monocytic leukemia. An important paralog of this gene is JADE2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLLT6 gene promoter:
         NF-1/L   NF-1   Pax-5   NF-kappaB   YY1   NF-kappaB2   HSF1short   ZIC2/Zic2   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT6 promoter sequence
   Search Chromatin IP Primers for MLLT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21

MLLT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P036861:  view genomic region     (about GC identifiers)

Start:
36,861,795 bp from pter      End:
36,886,056 bp from pter
Size:
24,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AF17_HUMAN, P55198 (See protein sequence)
Recommended Name: Protein AF-17  
Size: 1093 amino acids; 112076 Da
Sequence caution: Sequence=AAH07237.1; Type=Erroneous initiation; Sequence=BAB15670.1; Type=Erroneous initiation;
Secondary accessions: Q59F28 Q96IU3 Q9H5F6 Q9UF49

Explore the universe of human proteins at neXtProt for MLLT6: NX_P55198

Explore proteomics data for MLLT6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLLT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005928.2  
    ENSEMBL proteins: 
     ENSP00000367377   ENSP00000316426   ENSP00000462449  

    MLLT6 Human Recombinant Protein Products:

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    Novus Biologicals MLLT6 Protein
    Novus Biologicals MLLT6 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MLLT6

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    Cloud-Clone Corp. CLIAs for MLLT6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry P55198

    ProtoNet protein and cluster: P55198

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: AF17_HUMAN, P55198
    Similarity: Contains 2 PHD-type zinc fingers


    MLLT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MLLT6:
    AF-17 protein,fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia with granulocytic
    sarcomas,with translocation t(11;17)(q23;q21),may be the same as TCF11

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0008270zinc ion binding IEA--
         
    MLLT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mllt6):
     normal 

    MLLT6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLLT6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLLT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLLT6

    miRNA
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    miRTarBase miRNAs that target MLLT6:
    hsa-mir-103a-3p (MIRT027160), hsa-mir-23b-3p (MIRT046323), hsa-mir-93-5p (MIRT028129), hsa-mir-877-3p (MIRT036880), hsa-mir-16-5p (MIRT031921), hsa-mir-1303 (MIRT035889)

    Block miRNA regulation of human, mouse, rat MLLT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT6 (see all 129):
    hsa-miR-361-5p hsa-miR-640 hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-1260b hsa-miR-3921 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidMLLT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MLLT6
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MLLT6 (NM_005937)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MLLT6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AF17_HUMAN, P55198: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MLLT6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLLT6
    Interactions:

        Search GeneGlobe Interaction Network for MLLT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MLLT6 (P551981, 2, 3 ENSP000003164264) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEBPGP535672, 3, ENSP000002840004MINT-66061 I2D: score=5 STRING: ENSP00000284000
    MED15Q96RN52, 3, ENSP000002632054MINT-66283 I2D: score=5 STRING: ENSP00000263205
    UBQLN4Q9NRR51, 2, 3, ENSP000003572924EBI-740216,EBI-711226 MINT-2860922 I2D: score=3 STRING: ENSP00000357292
    CEBPEQ157443, ENSP000002065134I2D: score=3 STRING: ENSP00000206513
    DOT1LQ8TEK33, ENSP000003816574I2D: score=1 STRING: ENSP00000381657
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS8058765

    MLLT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLLT6 (AF17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MLLT6 gene: 
    NM_005937.3  

    Unigene Cluster for MLLT6:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
    Hs.91531  [show with all ESTs]
    Unigene Representative Sequence: NM_005937
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378137(uc010wdr.2) ENST00000325718(uc002hqi.4 uc002hqk.4 uc021twh.1)
    ENST00000578946(uc010cvm.1) ENST00000579179 ENST00000464666 ENST00000466997
    ENST00000471200(uc002hqj.3) ENST00000433891 ENST00000494578 ENST00000484263
    ENST00000582830
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLLT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT6 (see all 129):
    hsa-miR-361-5p hsa-miR-640 hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-1260b hsa-miR-3921 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidMLLT6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MLLT6
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT6
    Clone
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    OriGene clones in human, mouse for MLLT6 (see all 7)
    OriGene ORF clones in mouse, rat for MLLT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLLT6 (NM_005937)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MLLT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLLT6
      QuantiTect SYBR Green Assays in human, mouse, rat MLLT6
      QuantiFast Probe-based Assays in human, mouse, rat MLLT6

    Additional mRNA sequence: 

    AB209633.1 AF075118.1 AK057058.1 AK092893.1 AK310435.1 AK310437.1 AL832481.1 BC007237.1 
    BC007859.2 BC064612.1 S72604.1 U07932.1 

    Selected DOTS entries (see all 27):

    DT.92430050  DT.75108023  DT.417448  DT.455977  DT.91906484  DT.101978700  DT.120957804  DT.91971034 
    DT.120957836  DT.101969475  DT.95101979  DT.95181387  DT.95260533  DT.120640510  DT.86854954  DT.120957781 
    DT.120957807  DT.120957851  DT.91743969  DT.92430041  DT.92433764  DT.100779687  DT.120957840  DT.120957846 

    Selected AceView cDNA sequences (see all 467):

    BU731196 AA932452 AI951767 AW304320 BQ901187 AI249764 AK092893 AI566500 
    BC007237 AW129991 AI284418 AL133659 T32898 BQ917315 CA848153 BQ180876 
    BG236044 BU952136 AI125509 BE387140 AU185631 CB215830 AI627758 AW964167 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLLT6 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                          -                       -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                          -                                                                                                                                 
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MLLT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLLT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGACCC
    MLLT6 Expression
    About this image

    MLLT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLLT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91531
        Custom PCR Arrays for MLLT6
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    QuantiFast Probe-based Assays in human, mouse, rat MLLT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MLLT6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt61 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 88.47(n)1
    92.58(a)1
      11 (61.05 cM)5
    2461981  NM_139311.21  NP_647472.21 
     976634145 
    chicken
    (Gallus gallus)
    Aves MLLT61 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 69.9(n)
    68.6(a)
      419995  XM_418117.4  XP_418117.4 
    lizard
    (Anolis carolinensis)
    Reptilia MLLT66
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    62(a)
    1 ↔ 1
    6(72993971-73122165)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL961556.22   -- 81.9(n)    AL961556.2 
    worm
    (Caenorhabditis elegans)
    Secernentea zfp-13 Expression: intestine, pharynx, phasmid
    sensilla, more
    60(a)   III(8864569-8866029)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNT2(YGL131C)4 DNA binding protein with similarity to the S. pombe more   --   7(265859-261648) 852746  NP_011384.1 


    ENSEMBL Gene Tree for MLLT6 (if available)
    TreeFam Gene Tree for MLLT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLLT6 gene
    JADE22  BRD12  BRPF12  MLLT102  PHF142  JADE32  JADE12  BRPF32  
    10 SIMAP similar genes for MLLT6 using alignment to 5 protein entries:     AF17_HUMAN (see all proteins):
    AF10    ALL-1-AF17    MLL/AF10 fusion    MLLT10    JADE2    PHF15
    BRD1    DKFZp686E10210    DKFZp779J0967    BRPF3

    MLLT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLLT6 (see all 470)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412024751,2
    --32656262(+) GAACCA/GGAGCG 1 -- int10--------
    rs1143056981,2
    F--36860732(+) GCGGGT/CCTCTA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs37601491,2
    C--36860835(-) CACAGA/GCACGA 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs37601481,2
    C,F,A,H--36860927(-) ATATTC/ACTGCC 1 -- us2k120Minor allele frequency- A:0.11NS EA NA WA 2346
    rs1426799801,2
    C--36861056(+) CCCGAA/GGGCGG 1 -- us2k10--------
    rs1826893601,2
    --36861236(+) GGGGCC/TCGAGA 1 -- us2k10--------
    rs1156554701,2
    C,F--36861302(+) AAAAGA/CAAGCA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs2022264531,2
    C--36861857(+) CCCCGA/CCCCAG 1 -- us2k10--------
    rs2004884061,2
    C--36862000(+) GTACGC/GGGGTG 1 -- int10--------
    rs1141778741,2
    F--36862143(+) CCCCCC/AGCCCG 1 -- int11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for MLLT6 (36861795 - 36886056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MLLT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3160n71CNV Loss21882294
    nsv908194CNV Loss21882294
    nsv470585CNV Loss18288195
    nsv908196CNV Loss21882294
    nsv833438CNV Loss17160897
    esv21810CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLLT6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600328    OMIM disorders: --

    UniProtKB/Swiss-Prot: AF17_HUMAN, P55198
  • Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation
    t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein

  • 9 diseases for MLLT6:    About MalaCards
    acute monocytic leukemia    monocytic leukemia    leukemia    acute leukemia
    lymphoblastic leukemia    ataxia    sarcoma    multiple myeloma
    myeloma

    1 disease from the University of Copenhagen DISEASES database for MLLT6:
    Leukemia

    MLLT6 for disorders           About GeneDecksing


    Export disorders for MLLT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLLT6 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MLLT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. (PubMed id 8058765)1, 2, 3 Prasad R.... Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Characterization of the DOT1L network: implications of diverse roles for DOT1L. (PubMed id 20431927)1 Park G....Kim J.E. (Protein J. 2010)
    6. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. (PubMed id 19864429)1 Reisenauer M.R....Zhang W. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4302 HGNC: 7138 AceView: MLLT6 Ensembl:ENSG00000108292 euGenes: HUgn4302
    ECgene: MLLT6 H-InvDB: MLLT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLLT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLLT6 gene:
    Search GeneIP for patents involving MLLT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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