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Aliases for MLLT6 Gene

Aliases for MLLT6 Gene

  • MLLT6, PHD Finger Domain Containing 2 3 5
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Translocated To, 6 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 6 2 3
  • ALL1-Fused Gene From Chromosome 17 Protein 3 4
  • Trithorax Homolog 2 3
  • AF17 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 6 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 6 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To, 6 3
  • Protein AF-17 3

External Ids for MLLT6 Gene

Previous GeneCards Identifiers for MLLT6 Gene

  • GC17P036347
  • GC17P038855
  • GC17P036772
  • GC17P037236
  • GC17P034115
  • GC17P036861
  • GC17P032658

Summaries for MLLT6 Gene

GeneCards Summary for MLLT6 Gene

MLLT6 (MLLT6, PHD Finger Domain Containing) is a Protein Coding gene. Diseases associated with MLLT6 include Myeloid/Lymphoid Or Mixed Lineage Leukemia. An important paralog of this gene is MLLT10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT6 Gene

Genomics for MLLT6 Gene

Regulatory Elements for MLLT6 Gene

Enhancers for MLLT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038740 1.4 FANTOM5 Ensembl ENCODE 15.9 +37.0 37014 3.6 KLF1 PKNOX1 ZMYM3 BMI1 ZNF48 ZIC2 ZNF121 GLIS2 ZNF366 POLR2A C17orf98 PCGF2 MLLT6 FBXO47 PIP4K2B SOCS7 PSMB3 CISD3 LOC100287808 RNA5SP440
GH17F038724 1.1 ENCODE 16.6 +23.9 23921 10.8 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 PAF1 PCGF2 MLLT6 LINC02079 PGAP3 PSMB3 CWC25 CISD3 STAC2 ENSG00000279119
GH17F038677 1.3 Ensembl ENCODE 12.7 -28.4 -28441 1.0 ATF1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GATA2 ZNF143 ZNF207 MLLT6 PCGF2 CISD3 PIP4K2B PSMB3 CWC25 EPOP GC17M038684
GH17F038735 1.2 Ensembl ENCODE 11.6 +29.8 29767 0.6 HDGF ZNF76 KLF17 ARID4B SIN3A ZNF48 ZNF2 RAD21 GLIS2 ZNF143 MLLT6 CWC25 GC17M038732 RNA5SP440 LOC100287808
GH17F038674 1.1 ENCODE 12.6 -30.8 -30820 1.7 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 KLF13 SP3 PCGF2 CDK12 ENSG00000275665 ENSG00000266469 MED1 PIP4K2B MLLT6 CISD3 ENSG00000275532 SNORA21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MLLT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MLLT6 Gene

Chromosome:
17
Start:
38,705,542 bp from pter
End:
38,729,803 bp from pter
Size:
24,262 bases
Orientation:
Plus strand

Genomic View for MLLT6 Gene

Genes around MLLT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLLT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLLT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT6 Gene

Proteins for MLLT6 Gene

  • Protein details for MLLT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55198-AF17_HUMAN
    Recommended name:
    Protein AF-17
    Protein Accession:
    P55198
    Secondary Accessions:
    • Q59F28
    • Q96IU3
    • Q9H5F6
    • Q9UF49

    Protein attributes for MLLT6 Gene

    Size:
    1093 amino acids
    Molecular mass:
    112076 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH07237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15670.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MLLT6 Gene

Post-translational modifications for MLLT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLLT6 Gene

No data available for DME Specific Peptides for MLLT6 Gene

Domains & Families for MLLT6 Gene

Gene Families for MLLT6 Gene

Suggested Antigen Peptide Sequences for MLLT6 Gene

Graphical View of Domain Structure for InterPro Entry

P55198

UniProtKB/Swiss-Prot:

AF17_HUMAN :
  • Contains 1 C2HC pre-PHD-type zinc finger.
Similarity:
  • Contains 1 C2HC pre-PHD-type zinc finger.
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with MLLT6: view

Function for MLLT6 Gene

Molecular function for MLLT6 Gene

GENATLAS Biochemistry:
AF-17 protein,fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia with granulocytic sarcomas,with translocation t(11;17)(q23;q21),may be the same as TCF11

Gene Ontology (GO) - Molecular Function for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MLLT6: view
genes like me logo Genes that share phenotypes with MLLT6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLLT6 Gene

Localization for MLLT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLLT6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MLLT6: view

Pathways & Interactions for MLLT6 Gene

SuperPathways for MLLT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 8058765
GO:0007588 excretion IEA --
GO:0010765 positive regulation of sodium ion transport IEA --
GO:0035811 negative regulation of urine volume IEA --
GO:0035812 renal sodium excretion IEA --
genes like me logo Genes that share ontologies with MLLT6: view

No data available for Pathways by source and SIGNOR curated interactions for MLLT6 Gene

Transcripts for MLLT6 Gene

Unigene Clusters for MLLT6 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT6 Gene

No ASD Table

Relevant External Links for MLLT6 Gene

GeneLoc Exon Structure for
MLLT6
ECgene alternative splicing isoforms for
MLLT6

Expression for MLLT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MLLT6 Gene

Protein differential expression in normal tissues from HIPED for MLLT6 Gene

This gene is overexpressed in Brain (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MLLT6 Gene



NURSA nuclear receptor signaling pathways regulating expression of MLLT6 Gene:

MLLT6

SOURCE GeneReport for Unigene cluster for MLLT6 Gene:

Hs.91531
genes like me logo Genes that share expression patterns with MLLT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MLLT6 Gene

Orthologs for MLLT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLLT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLLT6 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia MLLT6 34
  • 92.78 (n)
cow
(Bos Taurus)
Mammalia MLLT6 34
  • 92.31 (n)
mouse
(Mus musculus)
Mammalia Mllt6 34 16
  • 88.47 (n)
rat
(Rattus norvegicus)
Mammalia Mllt6 34
  • 88.33 (n)
chicken
(Gallus gallus)
Aves MLLT6 34
  • 69.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mllt6 34
  • 63.16 (n)
worm
(Caenorhabditis elegans)
Secernentea zfp-1 36
  • 60 (a)
Species where no ortholog for MLLT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MLLT6 Gene

ENSEMBL:
Gene Tree for MLLT6 (if available)
TreeFam:
Gene Tree for MLLT6 (if available)

Paralogs for MLLT6 Gene

Paralogs for MLLT6 Gene

genes like me logo Genes that share paralogs with MLLT6: view

Variants for MLLT6 Gene

Sequence variations from dbSNP and Humsavar for MLLT6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1062041 -- 38,726,846(+) AGCCA(C/T)TAAGC utr-variant-3-prime
rs111527064 -- 38,715,416(+) ACACC(C/T)AGGAG intron-variant
rs111699371 -- 38,724,320(+) GGGCG(C/T)CTGTG intron-variant
rs111924031 -- 38,709,576(+) AGATG(A/G)TGAGT upstream-variant-2KB, splice-donor-variant
rs111935310 -- 38,707,721(+) TCTCC(A/G)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT6 Gene

Variant ID Type Subtype PubMed ID
esv21810 CNV gain 19812545
nsv1071381 CNV deletion 25765185
nsv1126456 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv470585 CNV loss 18288195
nsv833438 CNV loss 17160897
nsv953894 CNV deletion 24416366

Variation tolerance for MLLT6 Gene

Residual Variation Intolerance Score: 8.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLLT6 Gene

Human Gene Mutation Database (HGMD)
MLLT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLLT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT6 Gene

Disorders for MLLT6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MLLT6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myeloid/lymphoid or mixed lineage leukemia
  • mll
- elite association - COSMIC cancer census association via MalaCards
Search MLLT6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AF17_HUMAN
  • Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.

Relevant External Links for MLLT6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLLT6
genes like me logo Genes that share disorders with MLLT6: view

No data available for Genatlas for MLLT6 Gene

Publications for MLLT6 Gene

  1. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. (PMID: 8058765) Prasad R. … Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 64
  2. Af17 deficiency increases sodium excretion and decreases blood pressure. (PMID: 21546577) Chen L. … Zhang W. (J. Am. Soc. Nephrol. 2011) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for MLLT6 Gene

Sources for MLLT6 Gene

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