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Aliases for MLLT6 Gene

Aliases for MLLT6 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 6 2 3
  • AF17 3 4 6
  • ALL1-Fused Gene From Chromosome 17 Protein 3 4
  • Trithorax Homolog 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 6 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To, 6 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Translocated To, 6 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia 2
  • Translocated To 2
  • Protein AF-17 3
  • 6 2

External Ids for MLLT6 Gene

Previous GeneCards Identifiers for MLLT6 Gene

  • GC17P036347
  • GC17P038855
  • GC17P036772
  • GC17P037236
  • GC17P034115
  • GC17P036861
  • GC17P032658

Summaries for MLLT6 Gene

GeneCards Summary for MLLT6 Gene

MLLT6 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 6) is a Protein Coding gene. Diseases associated with MLLT6 include leukemia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT6 Gene

Genomics for MLLT6 Gene

Regulatory Elements for MLLT6 Gene

Genomic Location for MLLT6 Gene

Start:
38,705,542 bp from pter
End:
38,729,803 bp from pter
Size:
24,262 bases
Orientation:
Plus strand

Genomic View for MLLT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLLT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT6 Gene

Proteins for MLLT6 Gene

  • Protein details for MLLT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55198-AF17_HUMAN
    Recommended name:
    Protein AF-17
    Protein Accession:
    P55198
    Secondary Accessions:
    • Q59F28
    • Q96IU3
    • Q9H5F6
    • Q9UF49

    Protein attributes for MLLT6 Gene

    Size:
    1093 amino acids
    Molecular mass:
    112076 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH07237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15670.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MLLT6 Gene

Proteomics data for MLLT6 Gene at MOPED

Post-translational modifications for MLLT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLLT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MLLT6 Gene

Domains for MLLT6 Gene

Gene Families for MLLT6 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for MLLT6 Gene

Graphical View of Domain Structure for InterPro Entry

P55198

UniProtKB/Swiss-Prot:

AF17_HUMAN :
  • P55198
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with MLLT6: view

Function for MLLT6 Gene

Molecular function for MLLT6 Gene

GENATLAS Biochemistry: AF-17 protein,fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia with granulocytic sarcomas,with translocation t(11;17)(q23;q21),may be the same as TCF11

Gene Ontology (GO) - Molecular Function for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MLLT6: view

Phenotypes for MLLT6 Gene

MGI mutant phenotypes for MLLT6:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MLLT6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLLT6 Gene

Localization for MLLT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLLT6 Gene COMPARTMENTS Subcellular localization image for MLLT6 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MLLT6: view

Pathways for MLLT6 Gene

SuperPathways for MLLT6 Gene

No Data Available

Interacting Proteins for MLLT6 Gene

Gene Ontology (GO) - Biological Process for MLLT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 8058765
genes like me logo Genes that share ontologies with MLLT6: view

No data available for Pathways by source for MLLT6 Gene

Transcripts for MLLT6 Gene

Unigene Clusters for MLLT6 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT6 Gene

No ASD Table

Relevant External Links for MLLT6 Gene

GeneLoc Exon Structure for
MLLT6
ECgene alternative splicing isoforms for
MLLT6

Expression for MLLT6 Gene

mRNA expression in normal human tissues for MLLT6 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MLLT6 Gene

SOURCE GeneReport for Unigene cluster for MLLT6 Gene Hs.91531

genes like me logo Genes that share expressions with MLLT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MLLT6 Gene

Orthologs for MLLT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MLLT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLLT6 35
  • 99.83 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia MLLT6 35
  • 92.31 (n)
  • 96.52 (a)
dog
(Canis familiaris)
Mammalia MLLT6 35
  • 92.78 (n)
  • 96.6 (a)
mouse
(Mus musculus)
Mammalia Mllt6 35
  • 88.47 (n)
  • 92.58 (a)
Mllt6 16
rat
(Rattus norvegicus)
Mammalia Mllt6 35
  • 88.33 (n)
  • 92.6 (a)
chicken
(Gallus gallus)
Aves MLLT6 35
  • 69.9 (n)
  • 68.6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mllt6 35
  • 63.16 (n)
  • 65.42 (a)
worm
(Caenorhabditis elegans)
Secernentea zfp-1 37
  • 60 (a)
Species with no ortholog for MLLT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MLLT6 Gene

ENSEMBL:
Gene Tree for MLLT6 (if available)
TreeFam:
Gene Tree for MLLT6 (if available)

Paralogs for MLLT6 Gene

genes like me logo Genes that share paralogs with MLLT6: view

No data available for Paralogs for MLLT6 Gene

Variants for MLLT6 Gene

Sequence variations from dbSNP and Humsavar for MLLT6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1139109 -- 38,727,700(+) TGAGG(C/T)ACGAG utr-variant-3-prime, nc-transcript-variant
rs2109918 -- 38,726,371(+) cgtgc(A/G)tgtgt utr-variant-3-prime, nc-transcript-variant
rs2241012 - 38,711,886(+) GAGGC(A/G)CTGGA missense, reference, nc-transcript-variant
rs2241013 -- 38,712,210(+) TGGCT(C/G)TGTTA intron-variant
rs3785459 -- 38,711,019(-) GGCCC(A/G)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT6 Gene

Variant ID Type Subtype PubMed ID
nsv908194 CNV Loss 21882294
nsv833438 CNV Loss 17160897
nsv908196 CNV Loss 21882294
dgv3160n71 CNV Loss 21882294
nsv470585 CNV Loss 18288195
esv21810 CNV Gain 19812545

Relevant External Links for MLLT6 Gene

HapMap Linkage Disequilibrium report
MLLT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT6 Gene

Disorders for MLLT6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MLLT6 Gene including...

Search for MLLT6 Gene in MalaCards »

UniProtKB/Swiss-Prot

AF17_HUMAN
  • Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.

(1) University of Copenhagen DISEASES for MLLT6 Gene

genes like me logo Genes that share disorders with MLLT6: view

Publications for MLLT6 Gene

  1. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. (PMID: 8058765) Prasad R. … Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Protein partners of C/EBPepsilon. (PMID: 15588942) Chih D.Y. … Koeffler H.P. (Exp. Hematol. 2004) 3
  4. [Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5]. (PMID: 16086288) Pan J.L. … Wu Y.F. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for MLLT6 Gene

Sources for MLLT6 Gene

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