MLLT6 Gene
protein-coding GIFtS : 59
GC17P034115
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 (Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 6 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for MLLT6
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AF17 1 , 2 , 3 , 5 FLJ23480 1 , 2
Descriptions Myeloid/lymphoid or mixed-lineage leukemia, translocated to, 6 2 myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 6 1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 6 2 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 2 trithorax homolog 2
Search outside databases for aliases for MLLT6 genePrevious GC identifers: GC17P036347 GC17P038855 GC17P036772 GC17P037236
Summaries for MLLT6 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for MLLT6
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MLLT6 gene Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21 MLLT6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P034115:
(about GC identifiers )
Start:
34,115,399 bp from pter
End:
34,139,582 bp from pter
Size:
24,184 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000017.9 NT_010755.15 Proteins for MLLT6
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: AF17_HUMAN, P55198 (See
protein sequence )Recommended Name: Protein AF-17 Size : 1093 amino acids; 112076 Da
Subcellular location : Nucleus (Potential)
Secondary accessions : Q59F28 Q96IU3 Q9H5F6 Q9UF49
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_005928.2 ENSEMBL proteins: ENSP00000351063 ENSP00000367377 ENSP00000316426 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MLLT6: Assays for MLLT6:
Protein
Domains/ Families for MLLT6(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P55198 ProtoNet protein and cluster: P55198
1 Blocks protein family : IPB001965 Zn-finger-like UniProtKB/Swiss-Prot: AF17_HUMAN, P55198 Similarity : Contains 2 PHD-type zinc fingers
Gene Function for MLLT6
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): BC007237 Applied Biosystems Silencer ® siRNAs for MLLT6 Sigma-Aldrich siRNA and siRNA Panels for MLLT6 Sigma-Aldrich shRNA for MLLT6 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005937                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005937                                  untagged cDNA clones in CMV expression vector (see all 2 ): BC007237  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005937 Genatlas biochemistry entry for MLLT6 :AF-17 protein,fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia withgranulocytic sarcomas,with translocation t(11;17)(q23;q21),may be the same as TCF11 3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for MLLT6
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/16 Interacting proteins for MLLT6 (ENSP00000316426 3 P55198 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 16
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
TAS 8058765
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Drugs & Compounds for MLLT6 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MLLT6
Transcripts for MLLT6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): BC007237 Sigma-Aldrich siRNA and siRNA Panels for MLLT6 Sigma-Aldrich shRNA for MLLT6 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005937
REFSEQ mRNAs for MLLT6 gene: NM_005937.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005937
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005937                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005937                                  untagged cDNA clones in CMV expression vector (see all 2 ): BC007237  
Additional cDNA sequence: AF075118.1 AY459295.1
24/26 DOTS entries (see all 26
): DT.92430050 DT.75108023 DT.417448 DT.455977 DT.91906484 DT.101978700 DT.120957804 DT.91971034 DT.120957836 DT.101969475 DT.86854954 DT.95101979 DT.95181387 DT.95260533 DT.120640510 DT.120957781 DT.120957807 DT.120957851 DT.91743969 DT.92430041 DT.92433764 DT.100779687 DT.120957840 DT.120957846
24/467 AceView cDNA sequences (see all 467
):BQ233076 BU731196 AI368959 AA360288 BU624160 BI760193 AW848633 AW848124 BQ214429 AA262779 CK824032 BQ901187 BM989268 BC007859 AI475899 BQ022572 AA815126 CA417548 BQ180876 AA417049 CA309205 CF137370 CB215830 D19911
highest scoring ESTs for MLLT6 :AI828593 AA132504 AA132522 AA326663 AA432219 AA465241 AA465597 AA992444 AF075118 AI148029
Unigene Clusters for MLLT6: Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 Hs.91531 [show with all ESTs ] , Hs.605712 [show with all ESTs ] Unigene Representative Sequences: NM_005937 , BM473879 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MLLT6 (see all 10
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 :                         -         -                     SP2 :                                 -                     SP3 :         -                                             SP4 :         -                                             SP5 :                                                    
About this scheme ECgene alternative splicing isoforms for MLLT6 3 Ensembl transcripts including schematic representations : ENST00000358312
ENST00000378137
ENST00000325718
Expression for MLLT6
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MLLT6 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MLLT6 1 / 2 / 3
8 probe-sets matching MLLT6 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene clusters: Hs.91531 Hs.605712
Orthologs for MLLT6
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MLLT6 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for MLLT6 ENSEMBL Gene Tree for MLLT6 Paralogs for MLLT6 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MLLT6 gene PHF14 2 MLLT10 2
SNPs/Variants for MLLT6 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MLLT6 (up to first 250kb)
Disorders & Mutations for MLLT6
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600328 UniProtKB/Swiss-Prot: AF17_HUMAN, P55198
A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocationt(11;17)(q23;q21) with MLL/HRX. The result is a rogue activator protein
Medical News for MLLT6 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MLLT6 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for MLLT6 gene (see all 14
):
Search for MLLT6
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MLLT6
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MLLT6
(According to HUGE )
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Specialized Databases showing MLLT6 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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