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MLLT4 Gene

protein-coding GIFtS: 62

GC06P168046

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AF-6 ^¹, ²
AF6 ^¹, ², ³, ⁵
AFADIN ^²
FLJ34371 ^²
OTTHUMP00000017632 ^²
RP3-431P23.3 ^²

Descriptions
Protein AF-6 ^³
myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 ^¹
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 ^²
myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4 ^²

External Ids
HGNC: 7137¹
Entrez Gene: 4301²
UniProtKB: P55196³
Ensembl: ENSG00000130396⁷

Search outside databases for aliases for MLLT4 gene

Previous GC identifers: GC06M167426 GC06P167949 GC06P167985

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MLLT4:

AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras

activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya

et al., 1998 [PubMed 9722616]).[supplied by OMIM]

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196

Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system,

which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell

adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the

actin cytoskeleton

Gene Wiki entry for MLLT4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MLLT4 gene

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

MLLT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P168046: (about GC identifiers)

Start:	167,970,520 bp from pter
End:	168,115,552 bp from pter
Size:	145,033 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007302.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196 (See protein sequence)

Recommended Name: Afadin

Size: 1816 amino acids; 205605 Da

Subunit: Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the

association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts

with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1 and RIT2 (By

similarity). Interacts with NRXN1 and BCR

Subcellular location: Cell junction, adherens junction. Note=Not found at cell-matrix AJs

Sequence caution: Sequence=CAB82312.1; Type=Frameshift; Positions=1492, 1495, 1684;

PDB structures from and Proteopedia :

1T2M (3D)

1XZ9 (3D)

2AIN (3D)

2EXG (3D)

Secondary accessions: O75087 O75088 O75089 Q5TIG6 Q9NSN7 Q9NU92

Alternative splicing: 5 isoforms: P55196-1 P55196-2 P55196-3 P55196-4 P55196-5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001035089.1 NP_001035090.1 NP_005927.2

ENSEMBL proteins:

ENSP00000345834 ENSP00000355771 ENSP00000375960 ENSP00000252692 ENSP00000341118 ENSP00000355774

ENSP00000355770 ENSP00000375956

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for MLLT4
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (l Afadin, l + S Afadin )
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005911	cell-cell junction	TAS	10856295

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Antibodies for MLLT4:

	Invitrogen Antibodies for MLLT4
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MLLT4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (l Afadin, l + S Afadin ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MLLT4)
	Search Novus for antibodies for MLLT4

Assays for MLLT4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P55196

ProtoNet protein and cluster: P55196

4 Blocks protein families:

IPB000159 RA domain

IPB000253 Forkhead-associated (FHA)

IPB001478 PDZ/DHR/GLGF domain

IPB002710 Dilute (DIL) domain

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196

Domain: The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus

domain interacts with F-actin

Similarity: Contains 1 dilute domain

Similarity: Contains 1 FHA domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 2 Ras-associating domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MLLT4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005936

Applied Biosystems Silencer® siRNAs for MLLT4

Sigma-Aldrich siRNA for MLLT4

Sigma-Aldrich shRNA Panels and shRNA for MLLT4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040000
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040000
untagged cDNA clones in CMV expression vector (see all 5): NM_001040000

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001040001

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196

Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system,

which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell

adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the

actin cytoskeleton

Genatlas biochemistry entry for MLLT4:

GTP-Ha-Ras binding cytoplasmic protein AF-6,fused with HRX (MLL),in acute myeloid leukemia,with

translocation t(6;11)(q27;q23) in a VNTR rich region (see TSG6C)

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mllt4):

embryogenesis

growth/size

lethality-prenatal/perinatal

nervous system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008022	protein C-terminus binding	TAS	10856295

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for MLLT4 (Your Favorite Gene powered by Ingenuity)

Germ Cell-Sertoli Cell Junction Signaling
Leukocyte Extravasation Signaling
Tight Junction Signaling

GeneDecks MLLT4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MLLT4

5/66 Interacting proteins for MLLT4 (ENSP00000252692³ P55196^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 66 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRC	P12931²	STRING (score=.981) MINT-4950584 MINT-4961253 MINT-4961227 MINT-4961303 MINT-4961273 MINT-4961196 MINT-4961138
PVRL3	Q9NQS3²	STRING (score=.999) MINT-73129 MINT-58417 MINT-58408 MINT-73128
PVRL2	Q92692²	STRING (score=.999) MINT-58420 MINT-58186 MINT-58419
LMO2	P25791²	STRING (score=.966) MINT-16706 MINT-16707
MRAS	O14807²	STRING (score=.995) MINT-15307 MINT-15308

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10856295
GO:0007165	signal transduction	TAS	8242616
GO:0007267	cell-cell signaling	TAS	8242616

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MLLT4
2 Novoseek chemical compound relationships for MLLT4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	23.57	4	17971444 (1)
calcium	0.00	1	10583506 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MLLT4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005936

Sigma-Aldrich siRNA for MLLT4

Sigma-Aldrich shRNA Panels and shRNA for MLLT4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040000 NM_001040001 NM_005936

REFSEQ mRNAs for MLLT4 gene (3 alternative transcripts):

NM_001040000.1 NM_001040001.1 NM_005936.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001040000 NM_001040001 NM_005936

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040000
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040000
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001040000

Additional cDNA sequence:

AB209420.1 AF085836.1 AK055689.1 AK091815.1 AL161973.1 BC014505.1 BX649158.1 DQ387206.1

U02478.1

24 DOTS entries:

DT.416708 DT.91681622 DT.92434854 DT.95257198 DT.86857228 DT.100746217 DT.86845998 DT.100033596

DT.307131 DT.95222151 DT.95361714 DT.92016672 DT.92434873 DT.75109442 DT.95373845 DT.121321580

DT.75193246 DT.91652276 DT.92038220 DT.100667193 DT.121321582 DT.311481 DT.87046030 DT.95311230

17 AceView cDNA sequences:

AI497759 AI261345 AB016898 AA927364 CR600303 BV195201 AK091690 BX495366

AI914466 BG197963 CF994622 AW304129 AL535687 BX451476 BE672874 AW175690

BE463898

highest scoring ESTs for MLLT4:

AI800869 AA010703 AA010704 AA010818 AA010951 AA095337 AA301978 AA308378 AA320342 AA410259

Unigene Cluster for MLLT4:

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

Hs.644024 [show with all ESTs]

Unigene Representative Sequence: NM_001040001

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MLLT4 (see all 21 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	·	15c	^	16	^	17	^	18a	·	18b	^
SP1:																									-						-
SP2:
SP3:
SP4:
SP5:

ExUns:	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^	23	^	24	^	25	^	26	^	27a	·	27b	·	27c	^	28a	·	28b	·	28c	^	29a	·	29b	·	29c	^	30a	·	30b	^	31a	·	31b	^	32	^
SP1:
SP2:
SP3:																	-
SP4:																	-
SP5:																	-

ExUns:	33a	·	33b	·	33c	^	34	^	35a	·	35b	^	36a	·	36b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MLLT4

8 Ensembl transcripts including schematic representations:

ENST00000341575 ENST00000366806 ENST00000392112 ENST00000351017 ENST00000344191 ENST00000366809

ENST00000366805 ENST00000392108

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MLLT4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MLLT4

¹ / ² / ³

18 probe-sets matching MLLT4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
82598_at²^{, 3}	U95-E	1	1.00	1.00	0.66	1.26	AI884450	0.60	1.00	0.82	1
58844_s_at²^{, 3}	U95-C	1	1.00	1.00	0.74	1.54	AI800869	1.00	1.00	1.00	1
41105_s_at²^{, 3}	U95-A	1	1.00	1.00	0.67	0.30	U02478	0.60	1.00	0.82	1
65981_at²^{, 3}	U95-C	7	1.00	0.95	0.76	1.59	AW022140	0.80	1.00	0.91	1
80948_at²^{, 3}	U95-E	1	0.81	1.00	0.54	0.66	H24025	0.60	1.00	0.82	1
39511_at²^{, 3}	U95-A	1	0.44	1.00	-0.20	0.77	AB011399	0.20	1.00	0.72	1
230622_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE552393	0.40	1.00	0.76	1
214939_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB011399	0.20	1.00	0.72	1
208512_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005936	0.60	1.00	0.82	1
224685_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI675354	0.80	1.00	0.91	1
238871_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AI086124	0.40	1.00	0.76	1
215904_at*²	U133-A	NULL	0.00	0.00	--	--	--	--	--	--	--
230622_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214939_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208512_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224685_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238871_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
215904_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks MLLT4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.644024
Expression variation in blood from EXPOLDB for MLLT4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MLLT4 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MLLT4¹	--	myeloid/lymphoid or mixed-lineage leukemia (trithorax more	87.93(n) 93.58(a)	431695 XM_541201.2 XP_541201.2
chimpanzee (Pan troglodytes)	MLLT4¹	--	myeloid/lymphoid or mixed-lineage leukemia (trithorax more	99.57(n) 99.67(a)	463135 XM_518857.2 XP_518857.2
cow (Bos taurus)	MLLT4¹	--	myeloid/lymphoid or mixed-lineage leukemia (trithorax more	81.71(n) 88.97(a)	504856 XM_581038.3 XP_581038.3
rat (Rattus norvegicus)	Mllt4¹	--	myeloid/lymphoid or mixed-lineage leukemia (trithorax more	87.7(n) 93.36(a)	26955 NM_013217.1 NP_037349.1
mouse (Mus musculus)	Mllt4^{1, 5}	17⁵	myeloid/lymphoid or mixed-lineage leukemia (trithorax more^{1, 5}	87.96(n)¹ 93.4(a)¹	17356¹ XM_890447.2¹ XP_895540.2¹ AA023067⁵ AA939957⁵ (see all 29)

About this table Species with no ortholog for MLLT4

ENSEMBL Gene Tree for MLLT4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MLLT4 gene

ENSG00000215738²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/519 NCBI SNPs in MLLT4 are shown (see all 519 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 183)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1418^1,2	A,C,F,H,O	168107662(-)	`TTTCAC/AATAAT`	2	--	ut3¹ int¹		5		MN EU EA WA	602
	rs1415^1,2	A,C,F,O	168107720(-)	`TTATTC/TGCCTT`	2	--	ut3¹ int¹		4		MN NA	320
	rs1044292^1,2	A,C,F,H	168114604(+)	`GTTGGG/AGAGAC`	1	--	ut3¹		9		MN EU EA WA	1012
	rs3823458^1,2	A,C,F,H	168106976(+)	`TTCTTG/TGATAG`	2	--	ut3¹ int¹		4		EU EA WA	412
	rs9364373^1,2	A,C,F,H	168106838(+)	`TCATCT/CCGAGG`	2	--	int¹ ut3¹		3		EA WA	298
	rs9295030^1,2	A,F,H	168096114(+)	`CGGGGA/TCTCTG`	3	--	ng3¹ int¹		4		EU EA WA	420
	rs3734882^1,2	A,C,F	168106998(+)	`ATATTA/GATAGA`	2	--	int¹ ut3¹		1		EA	1492
--	rs6921553^1,2	C,F,H	168113340(+)	`TTCTGG/AGGCCC`	1	E/G	mis¹		4		EU EA WA	418
	rs3734884^1,2	A,C,F	168108581(+)	`CTCTAC/ATTTTC`	2	--	int¹ ng3¹		5		EA NA	1858
	rs9346634^1,2	A,C	168106808(+)	`TAGCCA/GTTGAG`	2	--	int¹ ut3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for MLLT4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 159559

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196

A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation

t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein

3 Novoseek disease relationships for MLLT4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	16.29	4	8703846 (3), 8950979 (1)
acute leukemia	15.67	1	9334353 (1)
tumors	5.47	1	16819513 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/103 PubMed articles for MLLT4 gene (see all 103 ):

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. (PubMed id 8242616)^{1, 2, 3, 4} Prasad R.... Canaani E. (1993)
Nectin and afadin: novel organizers of intercellular junctions. (PubMed id 12456712)^{1, 3, 4} Takai Y. and Nakanishi H. (2003)
Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PubMed id 11024295)^{1, 3, 4} Reymond N.... Lopez M. (2000)
Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene. (PubMed id 9679199)^{1, 3, 4} Saito S.... Nakamura Y. (1998)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Solution structure of AF-6 PDZ domain and its interaction with the C- terminal peptides from Neurexin and Bcr. (PubMed id 15684424)^{3, 4} Zhou H.... Shi Y. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{3, 4} Brill L.M....Peters E.C. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4301	HGNC: 7137	AceView: MLLT4.2	Ensembl:ENSG00000130396	euGenes: HUgn4301
ECgene: MLLT4	H-InvDB: MLLT4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MLLT4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MLLT4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MLLT4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MLLT4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MLLT4		Antibodies for MLLT4
	Explore super-pooled esiRNAs		Proteins for MLLT4
	Lentivirus-delivered shRNAs for MLLT4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (MLLT4)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (l Afadin, l + S Afadin )
	Antibodies (l Afadin, l + S Afadin )

Search OriGene for MLLT4

Search Tocris compounds for MLLT4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for MLLT4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MLLT4 Gene at Home site.
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MLLT4 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for MLLT4

Summaries
for MLLT4

Genomic Location
for MLLT4

Proteins
for MLLT4

Protein Domains/
Families
for MLLT4

Gene Function
for MLLT4

Pathways & Interactions
for MLLT4

Drugs & Compounds
for MLLT4

Transcripts
for MLLT4

Expression
for MLLT4

Orthologs
for MLLT4

Paralogs
for MLLT4

SNPs/Variants
for MLLT4

Disorders & Mutations
for MLLT4

Medical News
for MLLT4

Publications
for MLLT4

Search for MLLT4

Genome Databases showing MLLT4

Other Databases showing MLLT4

Specialized Databases showing MLLT4

Licensable Technologies
for MLLT4

Services
for MLLT4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MLLT4 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor MLLT4

Summariesfor MLLT4

Genomic Locationfor MLLT4

Proteinsfor MLLT4

Protein Domains/Familiesfor MLLT4

Gene Functionfor MLLT4

Pathways & Interactionsfor MLLT4

Drugs & Compoundsfor MLLT4

Transcriptsfor MLLT4

Expression for MLLT4

Orthologsfor MLLT4

Paralogsfor MLLT4

SNPs/Variantsfor MLLT4

Disorders & Mutationsfor MLLT4

Medical Newsfor MLLT4

Publicationsfor MLLT4

Search for MLLT4

Genome Databases showing MLLT4

Other Databases showing MLLT4

Specialized Databases showing MLLT4

Licensable Technologiesfor MLLT4

Servicesfor MLLT4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MLLT4

Summaries
for MLLT4

Genomic Location
for MLLT4

Proteins
for MLLT4

Protein Domains/
Families
for MLLT4

Gene Function
for MLLT4

Pathways & Interactions
for MLLT4

Drugs & Compounds
for MLLT4

Transcripts
for MLLT4

Expression
for MLLT4

Orthologs
for MLLT4

Paralogs
for MLLT4

SNPs/Variants
for MLLT4

Disorders & Mutations
for MLLT4

Medical News
for MLLT4

Publications
for MLLT4

Licensable Technologies
for MLLT4

Services
for MLLT4