MLLT4 Gene
protein-coding GIFtS: 63
GCID: GC06P168227
|
|
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,...(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
| |
Aliases
for MLLT4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila);Translocated To, 41 2 | | AF-61 | | AF61 2 3 5 | | Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog);Translocated To, 41 | | Protein AF-62 3 | | RP3-431P23.32 | | ALL1-Fused Gene From Chromosome 6 Protein2 3 | | Afadin1 |
Export aliases for MLLT4 gene to outside databasesPrevious GC identifers: GC06M167426 GC06P167949 GC06P167985 GC06P168046 GC06P165693 |
Summaries
for MLLT4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MLLT4:
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis.It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acutemyeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding differentisoforms have been described for this gene, however, not all have been fully characterized.(provided by RefSeq, May2011)
UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role inthe organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- andactin-filament-binding protein that connects nectin to the actin cytoskeleton
Gene Wiki entry for MLLT4
|
Genomic Views
for MLLT4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MLLT4 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MLLT4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MLLT4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27MLLT4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P168227: view genomic region
(about GC identifiers)
Start:
|
168,227,602 bp from pter |
End:
|
168,372,703 bp from pter |
Size:
|
145,102 bases |
Orientation:
|
plus strand |
|
Proteins
for MLLT4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196 (See
protein sequence)Recommended Name: Afadin Size: 1824 amino acids; 206804 Da
Subunit: Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin andE-cadherin. Isoform 1/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in anindirect manner. Interacts with RIT1 and RIT2 (By similarity). Interacts with NRXN1 and BCR
Subcellular location: Cell junction, adherens junction. Note=Not found at cell-matrix AJs
Sequence caution: Sequence=CAB82312.1; Type=Frameshift; Positions=1509, 1512, 1701;
4 PDB 3D structures from  and Proteopedia  for MLLT4:1T2M (3D)
1XZ9 (3D)
2AIN (3D)
2EXG (3D)
Secondary accessions: O75087 O75088 O75089 Q59FP0 Q5TIG6 Q5TIG7 Q9NSN7 Q9NU92Alternative splicing: 6 isoforms: P55196-4 P55196-2 P55196-1 P55196-3 P55196-6 P55196-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MLLT4: NX_P55196
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55196
MLLT4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035089.1 NP_001193937.1
ENSEMBL proteins: ENSP00000383626 ENSP00000341118 ENSP00000252692 ENSP00000375956 ENSP00000383625 ENSP00000404595 ENSP00000383623 ENSP00000414675 ENSP00000426462 ENSP00000421441 ENSP00000424188 ENSP00000423035 ENSP00000422166 ENSP00000355771 ENSP00000375960 Reactome Protein details: P55196
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
MLLT4 for ontologies About GeneDecksing
MLLT4 Antibody Products:
Assay Products for MLLT4: |
Protein
Domains /
Families
for MLLT4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MLLT4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P55196ProtoNet protein and cluster: P55196 4 Blocks protein families: IPB000159 RA domain IPB000253 Forkhead-associated (FHA) IPB001478 PDZ/DHR/GLGF domain IPB002710 Dilute (DIL) domain
UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196Domain: The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich C-terminus domain interacts withF-actinSimilarity: Contains 1 dilute domainSimilarity: Contains 1 FHA domainSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 2 Ras-associating domains |
Function
for MLLT4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role inthe organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- andactin-filament-binding protein that connects nectin to the actin cytoskeleton Genatlas biochemistry entry for MLLT4:GTP-Ha-Ras binding cytoplasmic protein AF-6,fused with HRX (MLL),in acute myeloid leukemia,with translocationt(6;11)(q27;q23) in a VNTR rich region (see TSG6C)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MLLT4 (NM_001040000) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLLT4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MLLT4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MLLT4:
Animal Models:
Mouse knock-outs for MLLT4: Mllt4tm1Mrcr Mllt4tm1Ytk
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Mllt4):
MLLT4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MLLT4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | | | 3 | Cell adhesion Tight junctions | | | 4 | Cell adhesion Endothelial cell contacts by junctional mechanisms | | | 5 | Cytoskeleton remodeling Slit-Robo signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for MLLT4
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MLLT4
1 
Cell Signaling Technology (CST) Pathway for MLLT4
3  GeneGo (Thomson Reuters) Pathways for MLLT4
4 
Reactome Pathways for MLLT4
3 
Kegg Pathways (Kegg details for MLLT4):
MLLT4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MLLT4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/77 Interacting proteins for MLLT4 (P551962, 3 ENSP000003836234) via UniProtKB, MINT, STRING, and/or I2D (see all 77)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PVRL3 | Q9NQS32, 3, ENSP000004180704 | MINT-73129 MINT-58417 MINT-58408 MINT-73128 I2D:
score=2 STRING: ENSP00000418070 | | PVRL2 | Q926922, 3, ENSP000002524834 | MINT-58420 MINT-58186 MINT-58419 I2D:
score=2 STRING: ENSP00000252483 | | LMO2 | P257912, 3, ENSP000002578184 | MINT-16706 MINT-16707 I2D:
score=3 STRING: ENSP00000257818 | | MRAS | O148072, 3, ENSP000002891044 | MINT-15307 MINT-15308 I2D:
score=2 STRING: ENSP00000289104 | | EPHB2 | P293232, 3, ENSP000003637634 | MINT-58184 I2D:
score=5 STRING: ENSP00000363763 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
MLLT4 for ontologies About GeneDecksing
|
Drugs & Compounds
for MLLT4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MLLT4 for compounds About GeneDecksing
 Browse Tocris compounds for MLLT4
1 DrugBank Compound for MLLT4 About this table
2 Novoseek chemical compound relationships for MLLT4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
25.3 |
6 |
17971444 (1), 19887591 (1) |
| calcium |
0 |
1 |
10583506 (1) |
Search CenterWatch for drugs/clinical trials and news about MLLT4 / AFAD
|
Transcripts
for MLLT4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MLLT4 gene (4 alternative transcripts): NM_001040000.2 NM_001207008.1 NM_001040001.1 NM_005936.2 Unigene Cluster for MLLT4: Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 Hs.614974 [show with all ESTs]Unigene Representative Sequence: NM_00104000018/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000400825 ENST00000344191(uc003qwb.1) ENST00000351017 ENST00000392108(uc003qwc.2)
ENST00000400824 ENST00000366809 ENST00000447894 ENST00000400822(uc021zik.1 uc021zim.1)
ENST00000423229(uc003qwf.3) ENST00000503021 ENST00000511637(uc003qwg.1)
ENST00000497596 ENST00000507679 ENST00000509296 ENST00000507704 ENST00000476946
ENST00000485634 ENST00000515794
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MLLT4 (NM_001040000) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MLLT4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4 |
Additional cDNA sequence: AB209420.1 AB621809.1 AF085836.1 AK055689.1 AK091815.1 AL161973.1 BC014505.1 BX649158.1 DQ387206.1 U02478.1 19 DOTS entries: DT.416708 DT.91681622 DT.92434854 DT.86857228 DT.100033596 DT.307131 DT.95222151 DT.92016672 DT.92434873 DT.95373845 DT.121321580 DT.75193246 DT.91652276 DT.92038220 DT.100667193 DT.121321582 DT.311481 DT.87046030 DT.95311230 17 AceView cDNA sequences: AB016898 CR600303 AI497759 AI261345 AA927364 BG197963 BV195201 AK091690 AI914466 BX495366 AW304129 AL535687 CF994622 BX451476 BE463898 AW175690 BE672874
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for MLLT4 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b | · | 28c | ^ | 29a | · | 29b | · | 29c | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 33a | · | 33b | · | 33c | ^ | 34 | ^ | 35a | · | 35b | ^ | 36a | · | 36b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MLLT4
|
Expression
for MLLT4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MLLT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MLLT4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MLLT4
SOURCE GeneReport for Unigene cluster: Hs.614974
SABiosciences Expression via Pathway-Focused PCR Arrays including MLLT4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLLT4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MLLT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MLLT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MLLT4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4 |
Orthologs
for MLLT4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MLLT4 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mllt41 , 5 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 |
86.88(n)1
92.71(a)1 |
|
17 (8.95 cM)5
173561 NM_010806.11 NP_034936.11
137605395 |
chicken
(Gallus gallus) |
Aves |
MLLT41 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax more |
80.44(n)
89.67(a) |
|
421564 XM_419605.3 XP_419605.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MLLT46 |
-- |
80(a) |
1 ↔ 1 |
1(224949666-225028887) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.225282 |
Xenopus laevis transcribed sequence with moderate similarity more |
82.28(n) |
|
BX845938.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mllt41 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax more |
70.84(n)
78.29(a) |
|
558359 XM_681563.5 XP_686655.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cno1 , 3 |
N receptor signaling pathway actin binding3
canoe1 |
51(a)3
49.04(n)1
43.61(a)1 |
|
406201 NM_079508.31 NP_524232.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
W03F11.6a3 |
-- |
33(a) |
|
I(2160073-2209334) -- |
ENSEMBL Gene Tree for MLLT4 (if available)
TreeFam Gene Tree for MLLT4 (if available) |
Paralogs
for MLLT4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MLLT4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MLLT4 (168227602 - 168372703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for MLLT4
15/24 CNVs (see all 24): 31312 5231 34566 8540 5229 51850 51849 5234 64719 53975 5235 8541 2667 99803 34495
1 Indel: 28173 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MLLT4 |
|
Disorders
/ Diseases
for MLLT4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MLLT4 for disorders About GeneDecksing
OMIM gene information: 159559
OMIM disorders: --
UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196
Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocationt(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein
12  diseases for MLLT4: About MalaCardsacute lymphoblastic leukemia leukemia acute myeloid leukemia lymphoblastic leukemia
myeloid leukemia monocytic leukemia acute monocytic leukemia herpes simplex
epithelial ovarian cancer ovarian cancer breast cancer neuronitis
3 Novoseek disease relationships for MLLT4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
14.2 |
4 |
8703846 (3), 8950979 (1) |
| acute leukemia |
13.7 |
1 |
9334353 (1) |
| tumors |
4.85 |
1 |
16819513 (1) |
Human Genome Epidemiology (HuGE) Navigator: MLLT4 (1 document)
Export disorders for MLLT4 gene to outside databases
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Publications
for MLLT4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MLLT4 gene, integrated from 9 sources (see all 129):
(articles sorted by number of sources associating them with MLLT4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. (PubMed id 8242616)1, 2, 3, 9 Prasad R.... Canaani E. (1993)
- Nectin and afadin: novel organizers of intercellular junctions. (PubMed id 12456712)1, 2, 9 Takai Y. and Nakanishi H. (2003)
- Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PubMed id 11024295)1, 2, 9 Reymond N.... Lopez M. (2000)
- Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene. (PubMed id 9679199)1, 2, 9 Saito S.... Nakamura Y. (1998)
- Solution structure of AF-6 PDZ domain and its interaction with the C- terminal peptides from Neurexin and Bcr. (PubMed id 15684424)1, 2 Zhou H.... Shi Y. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. (PubMed id 12808105)1, 9 Radziwill G....Moelling K. (2003)
- AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. (PubMed id 12590145)1, 9 Su L....Minato N. (2003)
- In vivo interaction of AF-6 with activated Ras and ZO-1. (PubMed id 10334923)1, 9 Yamamoto T....Kaibuchi K. (1999)
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External Searches for MLLT4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MLLT4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MLLT4 gene
(According to HUGE)
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| -- |
Specialized Databases showing MLLT4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for MLLT4 gene:
Search GeneIP for patents involving MLLT4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MLLT4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MLLT4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MLLT4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MLLT4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MLLT4 | | OriGene 3'-UTR Clone for MLLT4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MLLT4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | Antibodies & Assays for MLLT4 (afadin) |
| | | | Search Tocris compounds for MLLT4 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4 |
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