Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MLLT4 Gene

protein-coding   GIFtS: 67
GCID: GC06P168227

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 41 2
AF62 3 5
Protein AF-62 3
ALL1-Fused Gene From Chromosome 6 Protein2 3
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 41
afadin2

External Ids:    HGNC: 71371   Entrez Gene: 43012   Ensembl: ENSG000001303967   OMIM: 1595595   UniProtKB: P551963   

Export aliases for MLLT4 gene to outside databases

Previous GC identifers: GC06M167426 GC06P167949 GC06P167985 GC06P168046 GC06P165693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MLLT4 Gene:
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during
embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene,
involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene, however, not all have been fully
characterized.(provided by RefSeq, May 2011)

GeneCards Summary for MLLT4 Gene:
MLLT4 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4) is a protein-coding gene. Diseases associated with MLLT4 include lymphoblastic leukemia, and myeloid leukemia. GO annotations related to this gene include protein C-terminus binding and cell adhesion molecule binding. An important paralog of this gene is SAMD14.

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196
Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role
in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and
actin-filament-binding protein that connects nectin to the actin cytoskeleton

Gene Wiki entry for MLLT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLLT4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT4 promoter sequence
   Search Chromatin IP Primers for MLLT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

MLLT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P168227:  view genomic region     (about GC identifiers)

Start:
168,227,602 bp from pter      End:
168,372,703 bp from pter
Size:
145,102 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196 (See protein sequence)
Recommended Name: Afadin  
Size: 1824 amino acids; 206804 Da
Subunit: Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin and
E-cadherin. Isoform 1/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in
an indirect manner. Interacts with RIT1 and RIT2 (By similarity). Interacts with NRXN1 and BCR
Sequence caution: Sequence=CAB82312.1; Type=Frameshift; Positions=1509, 1512, 1701;
4 PDB 3D structures from and Proteopedia for MLLT4:
1T2M (3D)        1XZ9 (3D)        2AIN (3D)        2EXG (3D)    
Secondary accessions: O75087 O75088 O75089 Q59FP0 Q5TIG6 Q5TIG7 Q9NSN7 Q9NU92
Alternative splicing: 6 isoforms:  P55196-4   P55196-2   P55196-1   P55196-3   P55196-6   P55196-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MLLT4: NX_P55196

Explore proteomics data for MLLT4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn1246
  • Modification sites at PhosphoSitePlus

  • See MLLT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035089.1  NP_001193937.1  

    ENSEMBL proteins: 
     ENSP00000383626   ENSP00000341118   ENSP00000252692   ENSP00000375956   ENSP00000383625  
     ENSP00000404595   ENSP00000383623   ENSP00000414675   ENSP00000426462   ENSP00000421441  
     ENSP00000424188   ENSP00000423035   ENSP00000422166   ENSP00000355771   ENSP00000375960  
    Reactome Protein details: P55196

    MLLT4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MLLT4
    GenScript Custom Purified and Recombinant Proteins Services for MLLT4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLLT4

    MLLT4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MLLT4 (Afadin/AF-6)
    Cell Signaling Technology (CST) Antibodies for MLLT4  (afadin)
    OriGene Antibodies for MLLT4
    OriGene Custom Antibody Services for MLLT4
    Novus Biologicals MLLT4 Antibodies
    Abcam antibodies for MLLT4
    Cloud-Clone Corp. Antibodies for MLLT4
    ThermoFisher Antibodies for MLLT4
    LSBio Antibodies in human, mouse, rat for MLLT4

    MLLT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MLLT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MLLT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MLLT4
    Cloud-Clone Corp. CLIAs for MLLT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 7):
     IPR008984 SMAD_FHA_domain
     IPR028842 Afadin
     IPR018444 Dil_domain
     IPR002710 Dilute
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry P55196

    ProtoNet protein and cluster: P55196

    4 Blocks protein domains:
    IPB000159 RA domain
    IPB000253 Forkhead-associated (FHA)
    IPB001478 PDZ/DHR/GLGF domain
    IPB002710 Dilute (DIL) domain


    UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196
    Domain: The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich C-terminus domain interacts
    with F-actin
    Similarity: Contains 1 dilute domain
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 2 Ras-associating domains


    MLLT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AFAD_HUMAN, P55196
    Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role
    in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and
    actin-filament-binding protein that connects nectin to the actin cytoskeleton

         Genatlas biochemistry entry for MLLT4:
    GTP-Ha-Ras binding cytoplasmic protein AF-6,fused with HRX (MLL),in acute myeloid leukemia,with translocation
    t(6;11)(q27;q23) in a VNTR rich region (see TSG6C)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17491594
    GO:0008022protein C-terminus binding TAS10856295
    GO:0050839cell adhesion molecule binding IEA--
         
    MLLT4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MLLT4:
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mllt4):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  nervous system 

    MLLT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MLLT4: Mllt4tm1Mrcr Mllt4tm1Ytk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLLT4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLLT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MLLT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MLLT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLLT4:
    hsa-mir-92a-3p (MIRT049217), hsa-mir-346 (MIRT042714), hsa-mir-124-3p (MIRT022793), hsa-mir-15b-5p (MIRT046504), hsa-mir-335-5p (MIRT018175)

    Block miRNA regulation of human, mouse, rat MLLT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT4 (see all 58):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-let-7d hsa-miR-485-3p hsa-miR-500a hsa-miR-374a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MLLT4
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MLLT4

    Clone
    Products:
         
    OriGene clones in human, mouse for MLLT4 (see all 11)
    OriGene ORF clones in mouse, rat for MLLT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLLT4 (NM_001040000)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MLLT4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MLLT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AFAD_HUMAN, P55196: Cell junction, adherens junction. Note=Not found at cell-matrix AJs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane4
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    MLLT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MLLT4 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    4EphB-EphrinB Signaling
    Ephrin-Eph Signaling0.58
    5PAK Pathway
    Epithelial Adherens Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MLLT4
        Sertoli-Sertoli Cell Junction Dynamics
    Ephrin-Eph Signaling
    Epithelial Tight Junctions
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MLLT4
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for MLLT4
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions
    Cell adhesion Cadherin-mediated cell adhesion

    1 Reactome Pathway for MLLT4
        Adherens junctions interactions


    5 Kegg Pathways  (Kegg details for MLLT4):
        Ras signaling pathway
    Rap1 signaling pathway
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration


    MLLT4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MLLT4: 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MLLT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MLLT4 (P551961, 2, 3 ENSP000003836234) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129311, 2, 3, ENSP000003509414EBI-365875,EBI-621482 MINT-4950584 MINT-4961253 MINT-4961227 MINT-4961303 MINT-4961273 MINT-4961196 MINT-4961138 I2D: score=1 STRING: ENSP00000350941
    PVRL2Q926921, 2, 3, ENSP000002524834EBI-365875,EBI-718419 MINT-58420 MINT-58186 MINT-58419 I2D: score=2 STRING: ENSP00000252483
    PVRL3Q9NQS32, 3, ENSP000004180704MINT-73129 MINT-58417 MINT-58408 MINT-73128 I2D: score=2 STRING: ENSP00000418070
    LMO2P257912, 3, ENSP000002578184MINT-16706 MINT-16707 I2D: score=3 STRING: ENSP00000257818
    MRASO148072, 3, ENSP000002891044MINT-15307 MINT-15308 I2D: score=2 STRING: ENSP00000289104
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction IEA--
    GO:0007267cell-cell signaling TAS8242616
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--

    MLLT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLLT4 (AFAD)

    1 DrugBank Compound for MLLT4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE-- --target--10592235

    2 Novoseek inferred chemical compound relationships for MLLT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 25.3 6 17971444 (1), 19887591 (1)
    calcium 0 1 10583506 (1)



    MLLT4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MLLT4 gene (4 alternative transcripts): 
    NM_001040000.2  NM_001207008.1  NM_001040001.1  NM_005936.2  

    Unigene Cluster for MLLT4:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    Hs.614974  [show with all ESTs]
    Unigene Representative Sequence: NM_001040000
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000400825 ENST00000344191(uc003qwb.1) ENST00000351017 ENST00000392108(uc003qwc.2)
    ENST00000400824 ENST00000366809 ENST00000447894 ENST00000400822(uc021zik.1 uc021zim.1)
    ENST00000423229(uc003qwf.3) ENST00000503021 ENST00000511637(uc003qwg.1)
    ENST00000497596 ENST00000507679 ENST00000509296 ENST00000507704 ENST00000476946
    ENST00000485634 ENST00000515794
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLLT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT4 (see all 58):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-607 hsa-miR-4328 hsa-let-7d hsa-miR-485-3p hsa-miR-500a hsa-miR-374a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MLLT4
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT4
    Clone
    Products:
         
    OriGene clones in human, mouse for MLLT4 (see all 11)
    OriGene ORF clones in mouse, rat for MLLT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLLT4 (NM_001040000)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MLLT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLLT4
      QuantiTect SYBR Green Assays in human, mouse, rat MLLT4
      QuantiFast Probe-based Assays in human, mouse, rat MLLT4

    Additional mRNA sequence: 

    AB209420.1 AB621809.1 AF085836.1 AK055689.1 AK091815.1 AL161973.1 BC014505.1 BX649158.1 
    DQ387206.1 U02478.1 

    22 DOTS entries:

    DT.416708  DT.91681622  DT.92434854  DT.86857228  DT.100033596  DT.307131  DT.95222151  DT.92016672 
    DT.92434873  DT.95373845  DT.121321580  DT.75193246  DT.91652276  DT.92038220  DT.100667193  DT.121321582 
    DT.311481  DT.86845998  DT.87046030  DT.95311230  DT.95361714  DT.75109442 

    17 AceView cDNA sequences:

    CR600303 AI497759 AI261345 AB016898 AA927364 AI914466 BX495366 AK091690 
    BG197963 BV195201 AW304129 AL535687 BX451476 CF994622 AW175690 BE672874 
    BE463898 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MLLT4 (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                                          -                 -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                  -                                                                                                         
    SP4:                                                  -                                                                                                         
    SP5:                                                  -                                                                                                         

    ExUns: 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36a · 36b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for MLLT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MLLT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MLLT4 Expression
    About this image

    MLLT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLLT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.614974
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MLLT4: 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MLLT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLLT4
    QuantiTect SYBR Green Assays in human, mouse, rat MLLT4
    QuantiFast Probe-based Assays in human, mouse, rat MLLT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MLLT4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt41 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 87(n)1
    92.48(a)1
      17 (8.95 cM)5
    173561  NM_010806.11  NP_034936.11 
     137605395 
    chicken
    (Gallus gallus)
    Aves MLLT41 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 80.9(n)
    90.21(a)
      421564  XM_004935536.1  XP_004935593.1 
    lizard
    (Anolis carolinensis)
    Reptilia MLLT46
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    80(a)
    1 ↔ 1
    1(224949666-225058970)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.225282 Xenopus laevis transcribed sequence with moderate similarity more 82.28(n)    BX845938.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mllt41 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 71.06(n)
    78.38(a)
      558359  XM_681563.6  XP_686655.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta cno3 N receptor signaling pathway actin
    binding
    51(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea W03F11.6a3
    afd-11
    afd-11 33(a)3
    47.68(n)1
    39.92(a)1
      I(2160073-2209334)3
    1717761  NM_001026489.31  NP_001021660.11 


    ENSEMBL Gene Tree for MLLT4 (if available)
    TreeFam Gene Tree for MLLT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MLLT4 gene
    SAMD142  PPP1R9A2  PPP1R9B2  
    2 SIMAP similar genes for MLLT4 using alignment to 15 protein entries:     AFAD_HUMAN (see all proteins):
    MLL/AF6 fusion    DLG4

    MLLT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MLLT4 (see all 3372)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500442431,2
    --168236835(+) AACACA/TTCACA 2 -- us2k10--------
    rs1443323691,2
    --168236870(+) ACCCGA/GCGTGG 2 -- us2k10--------
    rs1408737931,2
    C--168236919(+) GGTGGA/GGGAGG 2 -- us2k10--------
    rs1447335891,2
    --168237010(+) GTTTCC/GACGTC 2 -- us2k10--------
    rs1478950731,2
    C--168237131(+) TACGTC/GTGCGA 2 -- us2k10--------
    rs1415703061,2
    C--168237190(+) AGACAC/TACAAA 2 -- us2k10--------
    rs1838243021,2
    --168237265(+) CACCCC/GAAGAG 2 -- us2k10--------
    rs1880974191,2
    --168237327(+) ACAACG/TTGTCC 2 -- us2k10--------
    rs1427749431,2
    C--168237390(+) AGGAAA/TCACCC 2 -- us2k10--------
    rs6114401,2
    C--168237471(+) CCCTTC/TGGAGA 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for MLLT4 (168227602 - 168372703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MLLT4 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2572068CNV Deletion19546169
    nsv820650CNV Deletion20802225
    esv2678919CNV Deletion23128226
    esv1558245CNV Deletion17803354
    esv991018CNV Deletion20482838
    dgv27e196CNV Duplication17116639
    esv2422263CNV Duplication17116639
    esv2422479CNV Duplication17116639
    nsv5593CNV Insertion18451855
    nsv509173CNV Insertion20534489

    Human Gene Mutation Database (HGMD): MLLT4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLLT4
    DNA2.0 Custom Variant and Variant Library Synthesis for MLLT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 159559    OMIM disorders: --

    UniProtKB/Swiss-Prot: AFAD_HUMAN, P55196
  • Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation
    t(6;11)(q27;q23) with KMT2A/MLL1. The result is a rogue activator protein

  • 16 diseases for MLLT4:    
    About MalaCards
    lymphoblastic leukemia    myeloid leukemia    leukemia    acute myeloid leukemia
    acute monocytic leukemia    monocytic leukemia    acute leukemia    herpes simplex
    parkinson's disease    ovarian cancer    endotheliitis    breast cancer
    multiple myeloma    myeloma    malaria    neuronitis


    MLLT4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MLLT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 14.2 4 8703846 (3), 8950979 (1)
    acute leukemia 13.7 1 9334353 (1)
    tumors 4.85 1 16819513 (1)

    Genetic Association Database (GAD): MLLT4
    Human Genome Epidemiology (HuGE) Navigator: MLLT4 (1 document)

    Export disorders for MLLT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MLLT4 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with MLLT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. (PubMed id 8242616)1, 2, 3, 9 Prasad R.... Canaani E. (Cancer Res. 1993)
    2. Nectin and afadin: novel organizers of intercellular junctions. (PubMed id 12456712)1, 2, 9 Takai Y. and Nakanishi H. (J. Cell Sci. 2003)
    3. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PubMed id 11024295)1, 2, 9 Reymond N.... Lopez M. (Gene 2000)
    4. Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene. (PubMed id 9679199)1, 2, 9 Saito S.... Nakamura Y. (DNA Res. 1998)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Solution structure of AF-6 PDZ domain and its interaction with the C- terminal peptides from Neurexin and Bcr. (PubMed id 15684424)1, 2 Zhou H.... Shi Y. (J. Biol. Chem. 2005)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. (PubMed id 12808105)1, 9 Radziwill G....Moelling K. (Mol. Cell. Biol. 2003)
    10. AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. (PubMed id 12590145)1, 9 Su L....Minato N. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4301 HGNC: 7137 AceView: MLLT4.2 Ensembl:ENSG00000130396 euGenes: HUgn4301
    ECgene: MLLT4 Kegg: 4301 H-InvDB: MLLT4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MLLT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MLLT4 gene:
    Search GeneIP for patents involving MLLT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for MLLT4 (Afadin/AF-6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MLLT4   OriGene RNAi products in human, mouse, rat for MLLT4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MLLT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MLLT4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MLLT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MLLT4   OriGene Custom Protein Services for MLLT4  

     
     
     Block miRNA regulation of human, mouse, rat MLLT4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MLLT4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT4 Predesigned siRNA for gene silencing in human, mouse, rat MLLT4
     QuantiFast Probe-based Assays in human, mouse, rat MLLT4 QuantiTect SYBR Green Assays in human, mouse, rat MLLT4
     PCR Arrays including human, mouse, rat MLLT4 Search Chromatin IP Primers for MLLT4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLLT4  GeneGlobe Interaction Network for MLLT4
     Regulatory tfbs in MLLT4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MLLT4 GenScript cDNA clones with any tag delivered in your preferred vector for MLLT4
     GenScript Custom Assay Services for MLLT4 GenScript Custom overexpressing Cell Line Services for MLLT4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MLLT4  (afadin)

     Search Tocris compounds for MLLT4 (AFAD)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MLLT4 antibodies
     Antibodies for MLLT4
     See all of Abcam's Antibodies, Kits and Proteins for MLLT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MLLT4
     Antibodies for MLLT4
     ELISAs for MLLT4
     CLIAs for MLLT4



     Browse ESI BIO Cell Lines and PureStem Progenitors for MLLT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MLLT4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MLLT4
     SwitchGear Promoter luciferase reporter plasmids for MLLT4
     ThermoFisher Antibodies for MLLT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MLLT4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MLLT4
     LSBio Antibodies in human, mouse, rat for MLLT4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MLLT4 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4