MLLT3 Gene
protein-coding GIFtS : 63
GC09M020334
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for MLLT3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AF-9 1 AF9 1 , 2 , 3 , 5 FLJ2035 2 OTTHUMP00000021127 2 OTTHUMP00000045120 2 YEATS3 1 , 2 , 3
Descriptions ALL1 fused gene from chromosome 9 protein 3 Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein 3 YEATS domain-containing protein 3 3 myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3 1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 2 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2
Search outside databases for aliases for MLLT3 genePrevious GC identifers: GC09M020675 GC09M020533
Summaries for MLLT3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for MLLT3
Genomic Location for MLLT3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MLLT3 gene Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22 MLLT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M020334:
(about GC identifiers )
Start:
20,334,968 bp from pter
End:
20,612,514 bp from pter
Size:
277,547 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000009.10 NT_008413.17 Proteins for MLLT3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: AF9_HUMAN, P42568 (See
protein sequence )Recommended Name: Protein AF-9 Size : 568 amino acids; 63351 Da
Subunit : Interacts with BCOR. Interacts with CBX8
Subcellular location : Nucleus (By similarity)
Secondary accessions : B1AMQ2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_004520.2 ENSEMBL proteins: ENSP00000369678 ENSP00000369680 ENSP00000348196 ENSP00000369695 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: MLLT3 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MLLT3: Assays for MLLT3:
Protein
Domains/ Families for MLLT3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P42568 ProtoNet protein and cluster: P42568
1 Blocks protein family : IPB005033 YEATS family UniProtKB/Swiss-Prot: AF9_HUMAN, P42568 Similarity : Contains 1 YEATS domain
Gene Function for MLLT3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004529 Applied Biosystems Silencer ® siRNAs for MLLT3 Sigma-Aldrich siRNA for MLLT3 Sigma-Aldrich shRNA for MLLT3 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004529                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004529                                  untagged cDNA clone in CMV expression vector: NM_004529  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004529 Genatlas biochemistry entry for MLLT3 :AF-9 protein,fused with HRX (MLL),in acute myeloid/lymphoid,monoblastic leukemia with granulocyticsarcomas mixed-lineage leukemia,with translocation t(9;11)(p22;q23)
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Mllt3) : Pathways & Interactions for MLLT3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MLLT3 5/23 Interacting proteins for MLLT3 (ENSP00000369695 3 P42568 2 ) via UniProtKB, MINT, and/or STRING (see all 23
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007379 segment specification
IEA -- GO:0009952 anterior/posterior pattern formation
IEA --
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Drugs & Compounds for MLLT3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MLLT3
Transcripts for MLLT3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004529 Sigma-Aldrich siRNA for MLLT3 Sigma-Aldrich shRNA for MLLT3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004529
REFSEQ mRNAs for MLLT3 gene: NM_004529.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004529
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004529                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004529                                  untagged cDNA clone in CMV expression vector: NM_004529  
Additional cDNA sequence: AK128222.1 AK225957.1 AK297587.1 AK301474.1 AK312914.1 BC030550.1 BC036089.1 BX649194.1 D16688.1 EF406122.1 L13744.1
12 DOTS entries : DT.114118 DT.121208968 DT.101959995 DT.91758472 DT.91894374 DT.100836178 DT.121208959 DT.453972 DT.97778208 DT.99966489 DT.99994733 DT.121208926
24/91 AceView cDNA sequences (see all 91
):L13744 AA442179 NM_004529 AI375975 BU623899 F11547 AI554049 BI710808 AW163788 BC030550 AW302520 BU733026 AK128222 AI911245 BM664793 AA621884 AL045208 BM793722 AW044133 AW157750 BM310961 BX420503 BF940546 AL535503
highest scoring ESTs for MLLT3 :L13744 BC036089 BF510928 BI550359 BI561777 BM018568 BX649194 AA002249 AA406302 AA421983
Unigene Cluster for MLLT3: Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 Hs.591085 [show with all ESTs ] Unigene Representative Sequence: NM_004529 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000380321
ENST00000380323
ENST00000355930
ENST00000380338
Expression for MLLT3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MLLT3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MLLT3 1 / 2 / 3
5 probe-sets matching MLLT3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAAAAGAAAGSOURCE GeneReport for Unigene cluster: Hs.591085 Expression variation in blood from EXPOLDB for MLLT3
Orthologs for MLLT3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MLLT3 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for MLLT3 ENSEMBL Gene Tree for MLLT3 Paralogs for MLLT3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MLLT3 gene MLLT1 2
SNPs/Variants for MLLT3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MLLT3 (up to first 250kb)
Disorders & Mutations for MLLT3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 159558 UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocationt(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein
5 Novoseek disease relationships for MLLT3 gene
About this table Human Gene Mutation Database : MLLT3
Medical News for MLLT3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MLLT3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/43 PubMed articles for MLLT3 gene (see all 43
):
Search for MLLT3
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MLLT3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MLLT3
(According to HUGE )
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--
Specialized Databases showing MLLT3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MLLT3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for MLLT3:
Recombinant Proteins (AF9 ) Antibodies (AF9 )
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