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Aliases for MLLT3 Gene

Aliases for MLLT3 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 3 2 3
  • AF9 3 4 6
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To Chromosome 3 Protein 3 4
  • ALL1-Fused Gene From Chromosome 9 Protein 3 4
  • YEATS Domain-Containing Protein 3 3 4
  • YEATS3 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 3 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To, 3 3
  • Protein AF-9 3

External Ids for MLLT3 Gene

Previous GeneCards Identifiers for MLLT3 Gene

  • GC09M020675
  • GC09M020533

Summaries for MLLT3 Gene

GeneCards Summary for MLLT3 Gene

MLLT3 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 3) is a Protein Coding gene. Diseases associated with MLLT3 include 'acute myeloid leukemia with t(9;11)(p22;q23)' and leukemia. Among its related pathways are Transcriptional misregulation in cancer. An important paralog of this gene is MLLT1.

UniProtKB/Swiss-Prot for MLLT3 Gene

  • Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Gene Wiki entry for MLLT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT3 Gene

Genomics for MLLT3 Gene

Regulatory Elements for MLLT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MLLT3 Gene

Start:
20,341,665 bp from pter
End:
20,622,543 bp from pter
Size:
280,879 bases
Orientation:
Minus strand

Genomic View for MLLT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT3 Gene

Proteins for MLLT3 Gene

  • Protein details for MLLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42568-AF9_HUMAN
    Recommended name:
    Protein AF-9
    Protein Accession:
    P42568
    Secondary Accessions:
    • B1AMQ2
    • B2R7B3
    • B7Z755
    • D3DRJ8
    • Q8IVB0

    Protein attributes for MLLT3 Gene

    Size:
    568 amino acids
    Molecular mass:
    63351 Da
    Quaternary structure:
    • Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8.

    Three dimensional structures from OCA and Proteopedia for MLLT3 Gene

    Alternative splice isoforms for MLLT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLLT3 Gene

Proteomics data for MLLT3 Gene at MOPED

Post-translational modifications for MLLT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLLT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MLLT3 Gene

Domains for MLLT3 Gene

Protein Domains for MLLT3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P42568

UniProtKB/Swiss-Prot:

AF9_HUMAN :
  • P42568
Domain:
  • Contains 1 YEATS domain.
genes like me logo Genes that share domains with MLLT3: view

No data available for Gene Families for MLLT3 Gene

Function for MLLT3 Gene

Molecular function for MLLT3 Gene

GENATLAS Biochemistry: AF-9 protein,fused with HRX (MLL),in acute myeloid/lymphoid,monoblastic leukemia with granulocytic sarcomas mixed-lineage leukemia,with translocation t(9;11)(p22;q23)
UniProtKB/Swiss-Prot Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Gene Ontology (GO) - Molecular Function for MLLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20153263
genes like me logo Genes that share ontologies with MLLT3: view
genes like me logo Genes that share phenotypes with MLLT3: view

Animal Model Products

CRISPR Products

miRNA for MLLT3 Gene

miRTarBase miRNAs that target MLLT3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLLT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLLT3 Gene

Localization for MLLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLLT3 Gene COMPARTMENTS Subcellular localization image for MLLT3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MLLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8506309
GO:0008023 transcription elongation factor complex IDA 22195968
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MLLT3: view

Pathways for MLLT3 Gene

genes like me logo Genes that share pathways with MLLT3: view

Pathways by source for MLLT3 Gene

1 KEGG pathway for MLLT3 Gene

Gene Ontology (GO) - Biological Process for MLLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007379 segment specification IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IGI 19591803
genes like me logo Genes that share ontologies with MLLT3: view

Transcripts for MLLT3 Gene

Unigene Clusters for MLLT3 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MLLT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT3 Gene

No ASD Table

Relevant External Links for MLLT3 Gene

GeneLoc Exon Structure for
MLLT3
ECgene alternative splicing isoforms for
MLLT3

Expression for MLLT3 Gene

mRNA expression in normal human tissues for MLLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLLT3 Gene

SOURCE GeneReport for Unigene cluster for MLLT3 Gene Hs.591085

genes like me logo Genes that share expressions with MLLT3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MLLT3 Gene

Orthologs for MLLT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MLLT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLLT3 35
  • 98.94 (n)
  • 100 (a)
MLLT3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLLT3 35
  • 95.41 (n)
  • 98.41 (a)
MLLT3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLLT3 35
  • 96.06 (n)
  • 98.77 (a)
MLLT3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mllt3 35
  • 92.9 (n)
  • 98.59 (a)
Mllt3 16
Mllt3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLLT3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLLT3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLLT3 35
  • 81.17 (n)
  • 83.3 (a)
MLLT3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLLT3 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25397 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549668 35
  • 81.86 (n)
  • 97.79 (a)
Str.17600 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7087 35
zebrafish
(Danio rerio)
Actinopterygii mllt3 36
  • 65 (a)
OneToOne
wufc39c11 35
fruit fly
(Drosophila melanogaster)
Insecta ear 36
  • 15 (a)
OneToMany
ear 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF14 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2675 36
  • 39 (a)
OneToMany
Species with no ortholog for MLLT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLLT3 Gene

ENSEMBL:
Gene Tree for MLLT3 (if available)
TreeFam:
Gene Tree for MLLT3 (if available)

Paralogs for MLLT3 Gene

Paralogs for MLLT3 Gene

Selected SIMAP similar genes for MLLT3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MLLT3: view

Variants for MLLT3 Gene

Sequence variations from dbSNP and Humsavar for MLLT3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs382642 -- 20,347,071(-) tGGGA(A/G)TTCCT intron-variant
rs383220 -- 20,348,184(-) CTGTT(A/G)TTGCA intron-variant
rs432871 -- 20,343,593(+) AGAGG(C/G)GCAGG utr-variant-3-prime
rs450608 -- 20,343,155(+) TTAAA(A/G)ATTAG utr-variant-3-prime
rs620286 -- 20,600,667(-) AAGGA(A/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT3 Gene

Variant ID Type Subtype PubMed ID
nsv466290 CNV Loss 19166990
esv269887 CNV Insertion 20981092
dgv8119n71 CNV Gain 21882294
nsv892722 CNV Gain 21882294

Relevant External Links for MLLT3 Gene

HapMap Linkage Disequilibrium report
MLLT3
Human Gene Mutation Database (HGMD)
MLLT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT3 Gene

Disorders for MLLT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MLLT3 Gene including...

Search for MLLT3 Gene in MalaCards »

UniProtKB/Swiss-Prot

AF9_HUMAN
  • Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

(1) University of Copenhagen DISEASES for MLLT3 Gene

(5) Novoseek inferred disease relationships for MLLT3 Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 71.5 1
lymphoblastic leukemia acute 62.5 1
leukemia 59 5
acute leukemia 56.8 1
chromosomal aberrations 47.5 2

Relevant External Links for MLLT3

Genetic Association Database (GAD)
MLLT3
Human Genome Epidemiology (HuGE) Navigator
MLLT3
genes like me logo Genes that share disorders with MLLT3: view

Publications for MLLT3 Gene

  1. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. (PMID: 8506309) Nakamura T. … Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. (PMID: 20471948) He N. … Zhou Q. (Mol. Cell 2010) 3 4
  4. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X. … Bell D.A. (PLoS ONE 2010) 3 48
  5. Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. (PMID: 23260655) Leach B.I. … Bushweller J.H. (Structure 2013) 3 4

Products for MLLT3 Gene

  • Addgene plasmids for MLLT3

Sources for MLLT3 Gene

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