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MLLT3 Gene

protein-coding   GIFtS: 63
GCID: GC09M020334

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila)...)
  See MLLT3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,
Drosophila); Translocated To, 31 2
     YEATS Domain-Containing Protein 32 3
AF92 3 5     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila)
Homolog); Translocated To, 31
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To Chromosome 3
Protein2 3
     Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog);
Translocated To, 32
YEATS32 3     Protein AF-92
ALL1-Fused Gene From Chromosome 9 Protein2 3     

External Ids:    HGNC: 71361   Entrez Gene: 43002   Ensembl: ENSG000001718437   OMIM: 1595585   UniProtKB: P425683   

Export aliases for MLLT3 gene to outside databases

Previous GC identifers: GC09M020675 GC09M020533


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MLLT3 Gene:
MLLT3 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3) is a protein-coding gene. Diseases associated with MLLT3 include leukemia. An important paralog of this gene is MLLT1.

UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of
RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the
DNA

Gene Wiki entry for MLLT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MLLT3 gene promoter:
         SRF   SRF (504 AA)   C/EBPalpha   MEF-2A   AREB6   POU2F1   POU2F1b   POU2F1a   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMLLT3 promoter sequence
   Search Chromatin IP Primers for MLLT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MLLT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

MLLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MLLT3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M020334:  view genomic region     (about GC identifiers)

Start:
20,341,663 bp from pter      End:
20,622,542 bp from pter
Size:
280,880 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AF9_HUMAN, P42568 (See protein sequence)
Recommended Name: Protein AF-9  
Size: 568 amino acids; 63351 Da
Subunit: Component of the super elongation complex (SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or
AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8
1 PDB 3D structure from and Proteopedia for MLLT3:
2LM0 (3D)    
Secondary accessions: B1AMQ2 D3DRJ8

Explore the universe of human proteins at neXtProt for MLLT3: NX_P42568

Explore proteomics data for MLLT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MLLT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273620.1  NP_004520.2  

    ENSEMBL proteins: 
     ENSP00000369695   ENSP00000369678   ENSP00000410482   ENSP00000348196  

    MLLT3 Human Recombinant Protein Products:

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    Novus Biologicals MLLT3 Proteins
    Novus Biologicals MLLT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MLLT3

     
    Search eBioscience for Proteins for MLLT3 

     
    antibodies-online proteins for MLLT3 (3 products) 

     
    antibodies-online peptides for MLLT3

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    antibodies-online antibodies for MLLT3 (39 products) 

    MLLT3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005033 YEATS

    Graphical View of Domain Structure for InterPro Entry P42568

    ProtoNet protein and cluster: P42568

    1 Blocks protein domain: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
    Similarity: Contains 1 YEATS domain


    Find genes that share domains with MLLT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AF9_HUMAN, P42568
    Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of
    RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the
    DNA

         Genatlas biochemistry entry for MLLT3:
    AF-9 protein,fused with HRX (MLL),in acute myeloid/lymphoid,monoblastic leukemia with granulocytic sarcomas
    mixed-lineage leukemia,with translocation t(9;11)(p22;q23)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MLLT3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mllt3):
     embryogenesis  growth/size/body  hematopoietic system  immune system  mortality/aging 
     no phenotypic analysis  skeleton  tumorigenesis 

    Find genes that share phenotypes with MLLT3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MLLT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MLLT3:
    hsa-mir-124-3p (MIRT022911)

    Block miRNA regulation of human, mouse, rat MLLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT3 (see all 38):
    hsa-miR-3938 hsa-miR-449a hsa-miR-124 hsa-miR-133a hsa-miR-3613-3p hsa-miR-506 hsa-miR-616 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidMLLT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MLLT3
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MLLT3 (see all 7)
    OriGene ORF clones in mouse, rat for MLLT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MLLT3 (NM_004529)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MLLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MLLT3
    Addgene plasmids for MLLT3 

    Cell Line
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AF9_HUMAN, P42568: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MLLT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MLLT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with MLLT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MLLT3):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MLLT3
    Interactions:

        GeneGlobe Interaction Network for MLLT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MLLT3 (P425681, 2, 3 ENSP000003696954) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-63744 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63746 I2D: score=4 
    AFF4Q9UHB71, 3, ENSP000002653434EBI-716132,EBI-395282 I2D: score=2 STRING: ENSP00000265343
    MCM6Q145662, 3, ENSP000002641564MINT-68179 I2D: score=4 STRING: ENSP00000264156
    APPBP2Q926242, 3, ENSP000000831824MINT-67647 I2D: score=4 STRING: ENSP00000083182
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007379segment specification IEA--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0090090negative regulation of canonical Wnt signaling pathway IGI19591803

    Find genes that share ontologies with MLLT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MLLT3 (AF9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MLLT3 gene (2 alternative transcripts): 
    NM_001286691.1  NM_004529.3  

    Unigene Cluster for MLLT3:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
    Hs.591085  [show with all ESTs]
    Unigene Representative Sequence: NM_004529
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380338(uc011lne.1 uc011lnf.1 uc003zoe.2) ENST00000380323
    ENST00000469261 ENST00000488705 ENST00000380321 ENST00000468513 ENST00000491137
    ENST00000475957(uc003zof.3) ENST00000429426 ENST00000355930
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MLLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MLLT3 (see all 38):
    hsa-miR-3938 hsa-miR-449a hsa-miR-124 hsa-miR-133a hsa-miR-3613-3p hsa-miR-506 hsa-miR-616 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidMLLT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MLLT3
    Predesigned siRNA for gene silencing in human, mouse, rat MLLT3
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    Addgene plasmids for MLLT3 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MLLT3
      QuantiTect SYBR Green Assays in human, mouse, rat MLLT3
      QuantiFast Probe-based Assays in human, mouse, rat MLLT3

    Additional mRNA sequence: 

    AK128222.1 AK225957.1 AK297587.1 AK301474.1 AK312914.1 BC030550.1 BC036089.1 BX649194.1 
    D16688.1 EF406122.1 L13744.1 

    12 DOTS entries:

    DT.114118  DT.121208968  DT.101959995  DT.91758472  DT.91894374  DT.100836178  DT.121208959  DT.453972 
    DT.97778208  DT.99994733  DT.121208926  DT.99966489 

    Selected AceView cDNA sequences (see all 91):

    BI710808 AK128222 BM664793 L13744 AW163788 AI911245 AA621884 AW302520 
    BC030550 NM_004529 AI554049 BU733026 AA442179 AI375975 F11547 BU623899 
    BX420503 N95149 BF510928 AL535503 BU616826 BM793722 CA439243 AA443284 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MLLT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAGAAAG
    MLLT3 Expression
    About this image


    MLLT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Epithalamus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Roof Plate
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
    MLLT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MLLT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591085
        Custom PCR Arrays for MLLT3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MLLT3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mllt31 , 5 myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 92.9(n)1
    98.59(a)1
      4 (41.06 cM)5
    701221  NM_027326.31  NP_081602.31 
     877699255 
    chicken
    (Gallus gallus)
    Aves MLLT31 myeloid/lymphoid or mixed-lineage leukemia (trithorax more 81.17(n)
    83.3(a)
      427234  XM_424818.4  XP_424818.4 
    lizard
    (Anolis carolinensis)
    Reptilia MLLT36
    myeloid/lymphoid or mixed-lineage leukemia (tritho...
    83(a)
    1 ↔ 1
    2(61994903-62152162)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253972 Xenopus laevis transcribed sequence with moderate similarity more 81.79(n)    BM180544.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc39c112 Transcribed sequence with moderate similarity to protein more 78.42(n)    57049447 
    fruit fly
    (Drosophila melanogaster)
    Insecta ear3 transcription initiation from Pol II
    promoter more
    35(a)   88F1   --


    ENSEMBL Gene Tree for MLLT3 (if available)
    TreeFam Gene Tree for MLLT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MLLT3 gene
    MLLT12  
    4 SIMAP similar genes for MLLT3 using alignment to 5 protein entries:     AF9_HUMAN (see all proteins):
    DKFZp686D09204    LTG9/MLLT3    MLLT1    YEATS4

    Find genes that share paralogs with MLLT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MLLT3 (see all 5634)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855079621,2
    --20344524(+) CACATA/CAAGAA 1 -- ds50010--------
    rs1906645361,2
    --20344533(+) AAGTGC/GACAAT 1 -- ds50010--------
    rs763370531,2
    F--20344560(+) GTACGG/TTTCAT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1830177381,2
    --20344629(+) ACGCTA/TCAGAG 1 -- ds50010--------
    rs1880890021,2
    --20344654(+) GAGCAG/TGGCTG 1 -- ds50010--------
    rs1392166861,2
    --20344841(+) AAGACA/GGCATC 1 -- ds50010--------
    rs1452907081,2
    --20344874(+) GATACC/TGGTCT 1 -- ds50010--------
    rs1932337061,2
    --20344899(+) AGACTG/TTCTTA 1 -- ds50010--------
    rs1472043491,2
    C--20345020(+) TCTCCA/TCTTAT 1 -- ut310--------
    rs1827171611,2
    --20345091(+) CTTTCA/TTTTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MLLT3 (20341663 - 20591663 bp, first 250kb of MLLT3)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MLLT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269887CNV Insertion20981092
    nsv466290CNV Loss19166990
    nsv892722CNV Gain21882294
    dgv8119n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): MLLT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MLLT3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159558    OMIM disorders: --

    UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
  • Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation
    t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein

  • 1 disease for MLLT3:    
    About MalaCards
    leukemia

    1 disease from the University of Copenhagen DISEASES database for MLLT3:
    Leukemia

    Find genes that share disorders with MLLT3           About GenesLikeMe

    5 Novoseek inferred disease relationships for MLLT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 71.5 1 10861294 (1)
    lymphoblastic leukemia acute 62.5 1 9331569 (1)
    leukemia 59 6 9331569 (2), 8681380 (1), 17344103 (1), 18948748 (1)
    acute leukemia 56.8 1 15269783 (1)
    chromosomal aberrations 47.5 2 8506309 (1), 9331569 (1)

    Genetic Association Database (GAD): MLLT3
    Human Genome Epidemiology (HuGE) Navigator: MLLT3 (3 documents)

    Export disorders for MLLT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MLLT3 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with MLLT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. (PubMed id 8506309)1, 2, 3, 9 Nakamura T.... Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. (PubMed id 23260655)1, 2 Leach B.I....Bushweller J.H. (Structure 2013)
    3. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. (PubMed id 20471948)1, 2 He N.... Zhou Q. (Mol. Cell 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    6. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. (PubMed id 11313972)1, 2 Garcia-Cuellar M.P.... Slany R.K. (Oncogene 2001)
    7. BCoR, a novel corepressor involved in BCL-6 repression. (PubMed id 10898795)1, 2 Huynh K.D.... Bardwell V.J. (Genes Dev. 2000)
    8. MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. (PubMed id 8414510)1, 3 Iida S.... Ueda R. (Oncogene 1993)
    9. Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. (PubMed id 20159978)1, 9 Lin J.J. and Hemenway C.S. (J. Biol. Chem. 2010)
    10. CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3. (PubMed id 23891621)1 Malik B. and Hemenway C.S. (FEBS Lett. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4300 HGNC: 7136 AceView: MLLT3 Ensembl:ENSG00000171843 euGenes: HUgn4300
    ECgene: MLLT3 Kegg: 4300 H-InvDB: MLLT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MLLT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MLLT3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MLLT3 gene:
    Search GeneIP for patents involving MLLT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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