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Aliases for MLLT3 Gene

Aliases for MLLT3 Gene

  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 3 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 3 2 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To Chromosome 3 Protein 3 4
  • ALL1-Fused Gene From Chromosome 9 Protein 3 4
  • YEATS Domain-Containing Protein 3 3 4
  • YEATS3 3 4
  • AF9 3 4
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 3 2
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To, 3 3
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To, 3 5
  • Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To 3 3

External Ids for MLLT3 Gene

Previous GeneCards Identifiers for MLLT3 Gene

  • GC09M020675
  • GC09M020533

Summaries for MLLT3 Gene

GeneCards Summary for MLLT3 Gene

MLLT3 (Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 3) is a Protein Coding gene. Diseases associated with MLLT3 include acute myeloid leukemia with t(9;11)(p22;q23) and myeloid/lymphoid or mixed lineage leukemia. Among its related pathways are Transcriptional misregulation in cancer. An important paralog of this gene is MLLT1.

UniProtKB/Swiss-Prot for MLLT3 Gene

  • Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Gene Wiki entry for MLLT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLLT3 Gene

Genomics for MLLT3 Gene

Regulatory Elements for MLLT3 Gene

Promoters for MLLT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MLLT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MLLT3 Gene

Chromosome:
9
Start:
20,341,665 bp from pter
End:
20,622,543 bp from pter
Size:
280,879 bases
Orientation:
Minus strand

Genomic View for MLLT3 Gene

Genes around MLLT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLLT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLLT3 Gene

Proteins for MLLT3 Gene

  • Protein details for MLLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42568-AF9_HUMAN
    Recommended name:
    Protein AF-9
    Protein Accession:
    P42568
    Secondary Accessions:
    • B1AMQ2
    • B2R7B3
    • B7Z755
    • D3DRJ8
    • Q8IVB0

    Protein attributes for MLLT3 Gene

    Size:
    568 amino acids
    Molecular mass:
    63351 Da
    Quaternary structure:
    • Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8.

    Three dimensional structures from OCA and Proteopedia for MLLT3 Gene

    Alternative splice isoforms for MLLT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLLT3 Gene

Proteomics data for MLLT3 Gene at MOPED

Post-translational modifications for MLLT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MLLT3 Gene

Antibody Products

No data available for DME Specific Peptides for MLLT3 Gene

Domains & Families for MLLT3 Gene

Protein Domains for MLLT3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P42568

UniProtKB/Swiss-Prot:

AF9_HUMAN :
  • Contains 1 YEATS domain.
Domain:
  • Contains 1 YEATS domain.
genes like me logo Genes that share domains with MLLT3: view

No data available for Gene Families for MLLT3 Gene

Function for MLLT3 Gene

Molecular function for MLLT3 Gene

GENATLAS Biochemistry:
AF-9 protein,fused with HRX (MLL),in acute myeloid/lymphoid,monoblastic leukemia with granulocytic sarcomas mixed-lineage leukemia,with translocation t(9;11)(p22;q23)
UniProtKB/Swiss-Prot Function:
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
genes like me logo Genes that share phenotypes with MLLT3: view

Animal Models for MLLT3 Gene

MGI Knock Outs for MLLT3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLLT3 Gene

Localization for MLLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLLT3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLLT3 Gene COMPARTMENTS Subcellular localization image for MLLT3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for MLLT3 Gene

Pathways & Interactions for MLLT3 Gene

genes like me logo Genes that share pathways with MLLT3: view

Pathways by source for MLLT3 Gene

1 KEGG pathway for MLLT3 Gene

Gene Ontology (GO) - Biological Process for MLLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009952 anterior/posterior pattern specification IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IGI 19591803
genes like me logo Genes that share ontologies with MLLT3: view

No data available for SIGNOR curated interactions for MLLT3 Gene

Drugs & Compounds for MLLT3 Gene

(1) Drugs for MLLT3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Montelukast Approved Pharma Antagonist 264
genes like me logo Genes that share compounds with MLLT3: view

Transcripts for MLLT3 Gene

Unigene Clusters for MLLT3 Gene

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLLT3 Gene

No ASD Table

Relevant External Links for MLLT3 Gene

GeneLoc Exon Structure for
MLLT3
ECgene alternative splicing isoforms for
MLLT3

Expression for MLLT3 Gene

mRNA expression in normal human tissues for MLLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MLLT3 Gene

This gene is overexpressed in Fetal Brain (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLLT3 Gene



SOURCE GeneReport for Unigene cluster for MLLT3 Gene Hs.591085

genes like me logo Genes that share expression patterns with MLLT3: view

Protein tissue co-expression partners for MLLT3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MLLT3 Gene

Orthologs for MLLT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MLLT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MLLT3 35
  • 95.41 (n)
  • 98.41 (a)
MLLT3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLLT3 35
  • 96.06 (n)
  • 98.77 (a)
MLLT3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mllt3 35
  • 92.9 (n)
  • 98.59 (a)
Mllt3 16
Mllt3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MLLT3 35
  • 98.94 (n)
  • 100 (a)
MLLT3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLLT3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLLT3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLLT3 35
  • 81.17 (n)
  • 83.3 (a)
MLLT3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLLT3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549668 35
  • 81.86 (n)
  • 97.79 (a)
Str.17600 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25397 35
zebrafish
(Danio rerio)
Actinopterygii wufc39c11 35
mllt3 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7087 35
fruit fly
(Drosophila melanogaster)
Insecta ear 37
  • 35 (a)
ear 36
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF14 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2675 36
  • 39 (a)
OneToMany
Species with no ortholog for MLLT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLLT3 Gene

ENSEMBL:
Gene Tree for MLLT3 (if available)
TreeFam:
Gene Tree for MLLT3 (if available)

Paralogs for MLLT3 Gene

Paralogs for MLLT3 Gene

(4) SIMAP similar genes for MLLT3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MLLT3: view

Variants for MLLT3 Gene

Sequence variations from dbSNP and Humsavar for MLLT3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs382642 -- 20,347,071(-) tGGGA(A/G)TTCCT intron-variant
rs383220 -- 20,348,184(-) CTGTT(A/G)TTGCA intron-variant
rs432871 -- 20,343,593(+) AGAGG(C/G)GCAGG utr-variant-3-prime
rs620286 -- 20,600,667(-) AAGGA(A/T)CAGAA intron-variant
rs734477 -- 20,604,462(-) TTGCT(G/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MLLT3 Gene

Variant ID Type Subtype PubMed ID
nsv466290 CNV Loss 19166990
esv269887 CNV Insertion 20981092
dgv8119n71 CNV Gain 21882294
nsv892722 CNV Gain 21882294

Variation tolerance for MLLT3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MLLT3 Gene

HapMap Linkage Disequilibrium report
MLLT3
Human Gene Mutation Database (HGMD)
MLLT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT3 Gene

Disorders for MLLT3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MLLT3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(9;11)(p22;q23)
  • aml with t(9;11)(p22;q23)
myeloid/lymphoid or mixed lineage leukemia
  • mll
acute monocytic leukemia
  • acute monoblastic leukemia and acute monocytic leukemia
acute leukemia
  • stem cell leukaemia
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search MLLT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AF9_HUMAN
  • Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Relevant External Links for MLLT3

Genetic Association Database (GAD)
MLLT3
Human Genome Epidemiology (HuGE) Navigator
MLLT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MLLT3
genes like me logo Genes that share disorders with MLLT3: view

No data available for Genatlas for MLLT3 Gene

Publications for MLLT3 Gene

  1. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. (PMID: 8506309) Nakamura T. … Canaani E. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23 67
  2. Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. (PMID: 20159978) Lin J.J. … Hemenway C.S. (J. Biol. Chem. 2010) 3 23
  3. MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. (PMID: 8414510) Iida S. … Ueda R. (Oncogene 1993) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. (PMID: 24565118) Mbonye U. … Karn J. (Virology 2014) 3

Products for MLLT3 Gene

Sources for MLLT3 Gene

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