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MLLT3 Gene

protein-coding   GIFtS: 63

GC09M020334
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AF-9 1
AF9 1, 2, 3, 5
FLJ2035 2
OTTHUMP00000021127 2
OTTHUMP00000045120 2
YEATS3 1, 2, 3
Descriptions
ALL1 fused gene from chromosome 9 protein 3
Myeloid/lymphoid or mixed-lineage leukemia translocated to
chromosome 3 protein 3
YEATS domain-containing protein 3 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax
(Drosophila) homolog); translocated to, 3 1
myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog); translocated to, 3 2
myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 2
External Ids
HGNC: 71361
Entrez Gene: 43002
UniProtKB: P425683
Ensembl: ENSG000001718437
Search outside databases for aliases for MLLT3 gene

Previous GC identifers: GC09M020675 GC09M020533

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for MLLT3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MLLT3 gene  

Entrez Gene cytogenetic band: 9p22   Ensembl cytogenetic band:  9p21.3   HGNC cytogenetic band: 9p22

MLLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M020334:     (about GC identifiers)

Start:
20,334,968 bp from pter
End:
20,612,514 bp from pter
Size:
277,547 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AF9_HUMAN, P42568 (See protein sequence)
Recommended Name: Protein AF-9  
Size: 568 amino acids; 63351 Da
Subunit: Interacts with BCOR. Interacts with CBX8
Subcellular location: Nucleus (By similarity)
Secondary accessions: B1AMQ2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004520.2  

    ENSEMBL proteins: 
    ENSP00000369678 ENSP00000369680 ENSP00000348196 ENSP00000369695 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (AF9)
    Human Recombinant Proteins from Abnova (MLLT3)
                  OriGene Purified Recombinant Human Protein: MLLT3 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS8506309
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for MLLT3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MLLT3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (AF9), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MLLT3)
    Novus Biologicals Antibodies for MLLT3

    Assays for MLLT3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR005033 YEATS


       GeneDecks  MLLT3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P42568

    ProtoNet protein and cluster: P42568

    1 Blocks protein family: IPB005033 YEATS family

    UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
    Similarity: Contains 1 YEATS domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MLLT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004529

                  Applied Biosystems Silencer® siRNAs for MLLT3

                  Sigma-Aldrich siRNA for MLLT3  
                         Sigma-Aldrich shRNA for MLLT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MLLT3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004529
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004529
                                     untagged cDNA clone in CMV expression vector: NM_004529 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004529

    Genatlas biochemistry entry for MLLT3:
    AF-9 protein,fused with HRX (MLL),in acute myeloid/lymphoid,monoblastic leukemia with granulocytic
    sarcomas mixed-lineage leukemia,with translocation t(9;11)(p22;q23)

    9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mllt3):

    embryogenesisgrowth/sizehematopoietic systemimmune systemlethality-postnatal
    lethality-prenatal/perinatalno phenotypic analysisskeletontumorigenesis

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MLLT3 


    5/23 Interacting proteins for MLLT3 (ENSP000003696953 P425682) via UniProtKB, MINT, and/or STRING (see all 23 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926242MINT-67647
    MCM6Q145662MINT-68179
    PTNP212462MINT-63744
    AFF1ENSP000003056893STRING (score=.997)
    BCORENSP000003677053STRING (score=.982)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007379 segment specification IEA--
    GO:0009952 anterior/posterior pattern formation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MLLT3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MLLT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004529

                  Sigma-Aldrich siRNA for MLLT3  
                         Sigma-Aldrich shRNA for MLLT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004529  

    REFSEQ mRNAs for MLLT3 gene: 

    NM_004529.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004529  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004529
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004529
                                     untagged cDNA clone in CMV expression vector: NM_004529 

    Additional cDNA sequence: 

    AK128222.1 AK225957.1 AK297587.1 AK301474.1 AK312914.1 BC030550.1 BC036089.1 BX649194.1 
    D16688.1 EF406122.1 L13744.1 

    12 DOTS entries:

    DT.114118  DT.121208968  DT.101959995  DT.91758472  DT.91894374  DT.100836178  DT.121208959  DT.453972 
    DT.97778208  DT.99966489  DT.99994733  DT.121208926 

    24/91 AceView cDNA sequences (see all 91 ):

    L13744 AA442179 NM_004529 AI375975 BU623899 F11547 AI554049 BI710808 
    AW163788 BC030550 AW302520 BU733026 AK128222 AI911245 BM664793 AA621884 
    AL045208 BM793722 AW044133 AW157750 BM310961 BX420503 BF940546 AL535503 

    highest scoring ESTs for MLLT3:

    L13744 BC036089 BF510928 BI550359 BI561777 BM018568 BX649194 AA002249 AA406302 AA421983 

    Unigene Cluster for MLLT3:

    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
    Hs.591085  [show with all ESTs]
    Unigene Representative Sequence: NM_004529


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000380321  ENST00000380323  ENST00000355930  ENST00000380338  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MLLT3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MLLT3

    1 / 2 / 3

    5 probe-sets matching MLLT3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35975_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 L13744 1.00 1.00 1.00 1

    204917_s_at2, 3 U133-A 1 1.00 1.00 -- -- AV756536 0.40 1.00 0.76 1

    204918_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004529 0.60 1.00 0.82 1

    204917_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    204918_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAAAAGAAAG

    SOURCE GeneReport for Unigene cluster: Hs.591085

    Expression variation in blood from EXPOLDB for MLLT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MLLT3 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MLLT31   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 96.06(n)
    98.77(a)
    481556  XM_538677.2  XP_538677.2 
    chimpanzee
    (Pan troglodytes)
    MLLT31   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 98.94(n)
    100(a)
    744085  XM_001148491.1  XP_001148491.1 
    cow
    (Bos taurus)
    MLLT31   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 96(n)
    99.12(a)
    521962  XM_600235.3  XP_600235.3 
    mouse
    (Mus musculus)
    Mllt31, 5 4 (42.50 cM)5
    myeloid/lymphoid or mixed-lineage leukemia (trithorax more1, 5 92.9(n)1
    98.59(a)1
    701221  NM_027326.31  NP_081602.31 
     AA2689445  AA6927625  (see all 30)
    chicken
    (Gallus gallus)
    MLLT31   -- myeloid/lymphoid or mixed-lineage leukemia (trithorax more 80.74(n)
    83.03(a)
    427234  XM_424818.2  XP_424818.2 
    About this table        Species with no ortholog for MLLT3

    ENSEMBL Gene Tree for MLLT3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MLLT3 gene
    MLLT12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1208 NCBI SNPs in MLLT3 are shown (see all 1208 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 412)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs101239951,2
    A,C,F,H20335372(+) CCAGAT/CTTTTA 1 -- ut317Minor allele frequency- C:0.14EU EA WA NA 556
    rs20738541,2
    C,F,H20613446(-) AYGCAC/AATTAC 1 -- ng319Minor allele frequency- A:0.22EA EU WA 1556
    rs78753261,2
    A,C,F20613283(+) GTGCCG/AGGTAC 1 -- ng312Minor allele frequency- A:0.22MN EA 1252
    rs101240441,2
    H20335503(+) TTTTTT/AAAATG 1 -- ut31 trp34Minor allele frequency- A:0.00EU EA WA 418
    rs108113771,2
    A20613450(+) TKTGCA/GTAAAT 1 -- ng310--------
    --
    rs17614451,2
    A,C20404376(-) agcagC/Tagcag 1 S/S syn1 ese30--------
    rs7344771,2
    A,C,F,H,O20594461(-) TTGCTT/GATATT 1 -- int110Minor allele frequency- G:0.14NA EA EU WA 810
    rs6202861,2
    A,C,F,H,O20590666(-) AAGGAT/ACAGAA 1 -- int112Minor allele frequency- A:0.38EA NA EU WA 1054
    rs23015481,2
    A,C,F,H,O20344575(+) GGCAAC/TGTAGG 1 -- int115Minor allele frequency- T:0.25EA NA EU WA 2722
    rs7347721,2
    A,C,F,H,O20376451(-) AGCTAC/TAGCCA 1 -- int18Minor allele frequency- T:0.19NA EU EA WA 630
    About this table

    HapMap Linkage Disequilibrium images for MLLT3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 159558

    UniProtKB/Swiss-Prot: AF9_HUMAN, P42568
  • A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation
    t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein
  • 5 Novoseek disease relationships for MLLT3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 72.55 1 10861294 (1)
    lymphoblastic leukemia acute 63.71 1 9331569 (1)
    leukemia 60.20 6 9331569 (2), 8681380 (1), 17344103 (1), 18948748 (1)
    acute leukemia 58.05 1 15269783 (1)
    chromosomal aberrations 48.77 2 8506309 (1), 9331569 (1)
    About this table

    Human Gene Mutation Database: MLLT3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/43 PubMed articles for MLLT3 gene (see all 43 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4300 HGNC: 7136 AceView: MLLT3 Ensembl:ENSG00000171843 euGenes: HUgn4300
    ECgene: MLLT3 H-InvDB: MLLT3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MLLT3 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MLLT3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for MLLT3 Antibodies for MLLT3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MLLT3 Browse small molecules at Sigma-Aldrich
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     Recombinant Proteins
    (AF9)
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for MLLT3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MLLT3

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