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AFF1 Gene

protein-coding GIFtS: 51

GC04P088075

AF4/FMR2 family, member 1
(Previous names: myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 2, pre-B-cell monocytic leukemia partner 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PBM1, MLLT2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AF-4 ^¹, ²
AF4 ^¹, ², ³
AF4-MLL ^²
FEL ^³
MGC134969 ^²
MLL/AF4 ^²
MLLT2 ^², ³
PBM1 ^², ³

Descriptions
AF4-MLL fusion protein ^²
AF4/FMR2 family, member 1 ^²
Protein AF-4 ^³
Protein FEL ^³
Proto-oncogene AF4 ^³
myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 2, pre-B-cell monocytic leukemia partner 1 ^¹
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 ^²
myeloid/lymphoid or mixed-lineage leukemia trithorax homolog 2 ^²
pre-B-cell monocytic leukemia partner 1 ^²

External Ids
HGNC: 7135¹
Entrez Gene: 4299²
UniProtKB: P51825³
Ensembl: ENSG00000172493⁷

Search outside databases for aliases for AFF1 gene

Previous GC identifer: GC04P088214

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for AFF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AFF1 gene

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.3 HGNC cytogenetic band: 4q21.3

AFF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P088075: (about GC identifiers)

Start:	88,147,177 bp from pter
End:	88,281,215 bp from pter
Size:	134,039 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AFF1_HUMAN, P51825 (See protein sequence)

Recommended Name: AF4/FMR2 family member 1

Size: 1210 amino acids; 131422 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAA36642.1; Type=Frameshift; Positions=897, 905, 1178;

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005926.1

ENSEMBL proteins:

ENSP00000378574 ENSP00000321097 ENSP00000378578 ENSP00000305689

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AF4)
	Human Recombinant Proteins from Abnova (AFF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for AFF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AF4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AFF1)
	Search Novus for antibodies for AFF1

Assays for AFF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P51825

ProtoNet protein and cluster: P51825

1 Blocks protein family: IPB007797 AF-4 proto-oncoprotein

UniProtKB/Swiss-Prot: AFF1_HUMAN, P51825

Similarity: Belongs to the AF4 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AFF1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005935

Applied Biosystems Silencer® siRNAs for AFF1

Sigma-Aldrich siRNA for AFF1

Sigma-Aldrich shRNA for AFF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005935
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005935
untagged cDNA clones in CMV expression vector (see all 2): NM_005935

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005935

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aff1):

behavior/neurological	growth/size	hematopoietic system	immune system	lethality-postnatal
nervous system	no phenotypic analysis	reproductive system	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	7689231
GO:0016563	transcription activator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/20 Interacting proteins for AFF1 (P51825² ENSP00000305689³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD9	O15198²	MINT-62122
MLLT1	ENSP00000252674³	STRING (score=.997)
MLLT3	ENSP00000369695³	STRING (score=.997)
SIAH2	ENSP00000322457³	STRING (score=.976)
MLL	ENSP00000374158³	STRING (score=.965)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045893	positive regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AFF1
1 Novoseek chemical compound relationship for AFF1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
af 10	76.18	2	15856011 (1), 16511515 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AFF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AFF1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005935

Sigma-Aldrich siRNA for AFF1

Sigma-Aldrich shRNA for AFF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005935

REFSEQ mRNAs for AFF1 gene:

NM_005935.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005935

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005935
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005935
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005935

Additional cDNA sequence:

AF024541.1 AF177236.1 AF177237.1 AF177238.1 AF177239.1 AF492831.1 AK296149.1 AK296243.1

AK300364.1 AK302199.1 BC017432.1 BC114930.1 DQ451148.1 L13743.1 L13773.1 L25050.1

21 DOTS entries:

DT.320060 DT.121271684 DT.95106539 DT.40217563 DT.121271853 DT.121271770 DT.207714 DT.91650693

DT.95156841 DT.101985638 DT.121271831 DT.75176196 DT.75188384 DT.95295713 DT.100734271 DT.121271747

DT.91874814 DT.95106675 DT.95110406 DT.121271880 DT.95106485

24/280 AceView cDNA sequences (see all 280 ):

AA256867 AI638134 BU428544 BU630914 AA582365 CA416095 AI189392 BF431765

AI075843 AI017397 BU173183 AI245167 AI401650 AW339615 AA962321 AA152192

BF196062 AA661744 CK903363 AI401199 AW303894 BU782668 T59667 AA701548

highest scoring ESTs for AFF1:

L13773 AA150141 AA152192 AA234146 AA234965 AA305835 AA312155 AA368567 AA483790 AA582365

Unigene Cluster for AFF1:

AF4/FMR2 family, member 1

Hs.480190 [show with all ESTs]

Unigene Representative Sequence: L13773

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000395142 ENST00000317423 ENST00000395146 ENST00000307808

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AFF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AFF1

¹ / ² / ³

11 probe-sets matching AFF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1883_s_at²^{, 3}	U95-A	1	1.00	1.00	0.11	0.15	HG4757-HT5207	0.20	1.00	0.72	1
39037_at²^{, 3}	U95-A	1	1.00	1.00	0.79	0.96	L13773	1.00	1.00	1.00	1
58632_at²	U95-B	3	0.88	0.44	0.79	1.04	--	--	--	--	--
211826_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L22179	0.20	0.17	0.18	3
201924_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005935	0.60	1.00	0.82	1
215451_s_at²^{, 3}	U133-A	2	1.00	0.68	--	--	BF575588	0.40	1.00	0.76	1
225389_at²	U133-B	4	0.91	0.46	--	--	--	--	--	--	--
211826_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201924_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215451_s_at²	U133Plus2	2	1.00	0.68	--	--	--	--	--	--	--
225389_at²	U133Plus2	4	0.91	0.46	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.480190

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AFF1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	AFF1¹	--	AF4/FMR2 family, member 1	99.23(n) 99.01(a)	461362 XM_001156948.1 XP_001156948.1
cow (Bos taurus)	AFF1¹	--	AF4/FMR2 family, member 1	84.97(n) 83.33(a)	781149 XM_001249488.1 XP_001249489.1
rat (Rattus norvegicus)	Aff1¹	--	AF4/FMR2 family, member 1	78.4(n) 74.51(a)	305152 XM_223161.4 XP_223161.4
mouse (Mus musculus)	Aff1^{1, 5}	5 (56.00 cM)⁵	AF4/FMR2 family, member 1^{1, 5}	80.12(n)¹ 75.53(a)¹	17355¹ NM_133919.3¹ NP_598680.3¹ AF013131⁵ AF074266⁵ (see all 24)
chicken (Gallus gallus)	AFF1¹	--	AF4/FMR2 family, member 1	63.14(n) 53.31(a)	422590 XM_420549.2 XP_420549.2

About this table Species with no ortholog for AFF1

ENSEMBL Gene Tree for AFF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AFF1 gene

AFF3² AFF2² AFF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/884 NCBI SNPs in AFF1 are shown (see all 884 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 324)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2926511^1,2	A,C,F,H,O	88281635(-)	`GCACCT/CAGGTC`	1	--	ng3¹		8	EU EA WA NA	636
	rs342460^1,2	C,F,H,O	88278266(-)	`GCACAT/CTTGTT`	1	--	ut3¹		12	EU EA WA NA	2448
	rs342458^1,2	C,F,H,O	88279049(-)	`TGTAAG/TGGAAA`	1	--	ut3¹		9	MN EA NA EU WA	2232
	rs3755979^1,2	A,C,F,H	88277364(-)	`AGTAAG/CTGTGC`	1	--	ut3¹ ese³		7	EA NA WA	1932
	rs342461^1,2	A,C,F,H	88277496(-)	`CATTAT/CAAATA`	1	--	ut3¹		9	MN EU EA WA NA	2228
	rs1408^1,2	A,C,F,H	88276377(-)	`AGTTAT/CTAAAC`	1	--	ut3¹ ese³		13	MN NA EU EA WA	1062
	rs342459^1,2	A,C,F,H	88278439(-)	`CAGACC/TTCTAT`	1	--	ut3¹ ese³		17	MN EA NA EU WA	2802
	rs10029915^1,2	C,F,H	88278641(+)	`AGAGTG/CTAAAT`	1	--	ut3¹		7	EU EA WA NA	556
	rs3733378^1,2	C,F,H	88187357(-)	`AGGGGG/CAACTG`	1	A/P	mis¹ trp³		9	EA EU WA	2320
	rs342462^1,2	C,F,H	88276505(-)	`AGGAGC/TGGGGG`	1	--	ut3¹ ese³		6	MN EU EA WA	1344

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HapMap Linkage Disequilibrium images for AFF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 159557

UniProtKB/Swiss-Prot: AFF1_HUMAN, P51825

A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation

t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein

6 Novoseek disease relationships for AFF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	77.92	10	11719380 (1), 11493704 (1), 12433702 (1), 15221006 (1) (see all 9)
acute leukemia	75.25	6	8353274 (1), 7698025 (1), 11527155 (1), 8378328 (1) (see all 6)
leukemogenesis	70.29	6	9737688 (2), 9808577 (1), 9365243 (1)
leukemia	69.17	20	9808577 (2), 9737688 (2), 9403001 (2), 17889710 (1) (see all 14)
chromosomal aberrations	41.32	1	8506309 (1)
tumors	4.40	2	8378328 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/75 PubMed articles for AFF1 gene (see all 75 ):

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. (PubMed id 1423625)^{1, 2, 3, 4} Gu Y....Canaani E. (1992)
The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. (PubMed id 8353274)^{1, 2, 3} Chen C.S....Kersey J.H. (1993)
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. (PubMed id 8506309)^{1, 3, 4} Nakamura T.... Canaani E. (1993)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. (PubMed id 7689231)^{2, 3} Domer P.H....Korsmeyer S.J. (1993)
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias. (PubMed id 8443374)^{3, 4} Morrissey J....Cleary M.L. (1993)
Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints. (PubMed id 10671636)^{1, 3} Felix C.A....Rappaport E.F. (1999)
Exon/intron structure of the human AF-4 gene, a member of the AF- 4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. (PubMed id 9233580)^{1, 3} Nilson I.... Marschalek R. (1997)
Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited. (PubMed id 16433901)^{1, 3} Gue M....Boudier T. (2006)
Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? (PubMed id 15221006)^{1, 3} Bursen A....Marschalek R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4299	HGNC: 7135	AceView: MLLT2	Ensembl:ENSG00000172493	euGenes: HUgn4299
ECgene: AFF1	H-InvDB: AFF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for AFF1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AFF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AFF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AFF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AFF1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AFF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AFF1)
	Antibodies (AFF1)
	Chimera RNAi (AFF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (AF4)
	Antibodies (AF4)

Search OriGene for AFF1

Search Tocris compounds for AFF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for AFF1

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AFF1 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for AFF1

Summaries
for AFF1

Genomic Location
for AFF1

Proteins
for AFF1

Protein Domains/
Families
for AFF1

Gene Function
for AFF1

Pathways & Interactions
for AFF1

Drugs & Compounds
for AFF1

Transcripts
for AFF1

Expression
for AFF1

Orthologs
for AFF1

Paralogs
for AFF1

SNPs/Variants
for AFF1

Disorders & Mutations
for AFF1

Medical News
for AFF1

Publications
for AFF1

Search for AFF1

Genome Databases showing AFF1

Other Databases showing AFF1

Specialized Databases showing AFF1

Licensable Technologies
for AFF1

Services
for AFF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AFF1 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor AFF1

Summariesfor AFF1

Genomic Locationfor AFF1

Proteinsfor AFF1

Protein Domains/Familiesfor AFF1

Gene Functionfor AFF1

Pathways & Interactionsfor AFF1

Drugs & Compoundsfor AFF1

Transcriptsfor AFF1

Expression for AFF1

Orthologsfor AFF1

Paralogsfor AFF1

SNPs/Variantsfor AFF1

Disorders & Mutationsfor AFF1

Medical Newsfor AFF1

Publicationsfor AFF1

Search for AFF1

Genome Databases showing AFF1

Other Databases showing AFF1

Specialized Databases showing AFF1

Licensable Technologiesfor AFF1

Servicesfor AFF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AFF1

Summaries
for AFF1

Genomic Location
for AFF1

Proteins
for AFF1

Protein Domains/
Families
for AFF1

Gene Function
for AFF1

Pathways & Interactions
for AFF1

Drugs & Compounds
for AFF1

Transcripts
for AFF1

Expression
for AFF1

Orthologs
for AFF1

Paralogs
for AFF1

SNPs/Variants
for AFF1

Disorders & Mutations
for AFF1

Medical News
for AFF1

Publications
for AFF1

Licensable Technologies
for AFF1

Services
for AFF1